Page last updated: 2024-08-21

oleanolic acid and betulonic acid

oleanolic acid has been researched along with betulonic acid in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.08)18.2507
2000's13 (27.08)29.6817
2010's23 (47.92)24.3611
2020's11 (22.92)2.80

Authors

AuthorsStudies
Auwerx, J; Boudjelal, G; Genet, C; Lobstein, A; Saladin, R; Schmidt, C; Schoonjans, K; Souchet, M; Strehle, A; Wagner, A1
García-Cámara, I; Moo-Puc, RE; Peraza-Sánchez, SR; Torres-Tapia, LW; Valencia-Chan, LS1
Basnet, P; Hozumi, T; Kadota, S; Kawana, T; Kurokawa, M; Namba, T; Ohsugi, M; Shiraki, K1
Kim, DS; Kim, JY; Koo, HM1
Cleris, L; Formelli, F; Gambacorti-Passerini, C; Marchesi, E; Righetti, SC; Supino, R; Zuco, V1
Akihisa, T; Ichiishi, E; Kimura, Y; Nakahara, T; Nishino, H; Takamine, Y; Tokuda, H; Ukiya, M; Yokochi, T; Yoshizumi, K1
Chen, B; Mi, HM; Wu, YT; Xing, WX; Yang, GJ; Zhu, M1
Boreko, EI; Flekhter, OB; Nikolaeva, SN; Pavlova, NI; Savinova, OV1
Sun, YR; Zhang, D; Zhang, QW; Zhang, YX1
Grek, OR; Pozdnyakova, SV; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA1
Choi, SU; Choi, SZ; Lee, KR; Yang, MC1
Bomshteyn, A; Hao, M; Katdare, M; Kisilis, E; Oktem, O; Rathnam, P; Saxena, BB; Zhu, L1
Tanaka, R; Wada, S1
Bastos, DZ; de Jesus, DA; de Oliveira, BH; Pimentel, IC1
Klinnikova, MG; Lushnikova, EL; Molodykh, OP; Nepomnyashchikh, LM; Sorokina, IV; Sviridov, EA; Tolstikova, TG; Zhukova, NA1
Alabugin, IV; Baev, DS; Govdi, AI; Shakirov, MM; Shults, EE; Sorokina, IV; Tolstikov, GA; Tolstikova, TG; Vasilevsky, SF1
Alakurtti, S; Bergström, P; Jaffe, CL; Sacerdoti-Sierra, N; Yli-Kauhaluoma, J1
Alabugin, IV; Baev, DS; Govdi, AI; Mamatuyk, VI; Sorokina, IV; Tolstikov, GA; Tolstikova, TG; Vasilevsky, SF1
Lushnikova, EL; Nepomnyashih, LM; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA1
Li, GL; Song, CH; Suo, YR; Xia, L; You, JM; Zheng, J1
Bębenek, E; Boryczka, S; Jastrzebska, M; Kadela, M; Kusz, J; Michalik, E; Zubko, M1
Burlova, I; Gulenova, M; Kiseleva, T; Kislitsin, CA; Klabukova, I; Melnikova, N; Tanaseichuk, B; Vasin, V1
Baev, DS; Bessergeneva, EP; Glukhov, BM; Nepomnyaschikh, GI; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA1
Chen, N; Ding, G; Gu, J; Zhang, Z1
Andrei, G; Balzarini, J; De Borggraeve, W; Dehaen, W; Dinh Ngoc, T; Kim, Y; Mashentseva, A; Moons, N; Snoeck, R1
Chen, G; Hu, N; Li, G; Liu, D; Liu, S; Suo, Y; Wu, H; You, J1
Baiev, DS; Biryukova, MS; Ivanova, EP; Nepomnyashchikh, GI; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA1
Hu, DY; Liu, MC; Xue, W; Yang, S; Yang, SJ; Zhao, Q1
Huang, GQ; Li, B; Lu, RM; Wei, JH; Zhong, ZG1
Avram, Ş; Bercean, V; Dehelean, C; Ledeţi, A; Ledeţi, I; Mioc, M; Şoica, C; Şuta, LM; Vlase, G; Vlase, T; Zupko, I1
Baranovsky, AV; Khlebnicova, TS; Kumpiņš, V; Lakhvich, FA; Mieriņa, I; Peipiņš, U; Piven, YA; Rāviņa, I; Rijkure, I; Shishkina, SV; Tetere, Z; Turks, M; Zicāne, D1
Ayers, S; Benkovics, T; Kiau, S; Marshall, J; Strotman, NA; Tan, Y1
Awang, K; Din, MF; Ishitani, T; Kulkeaw, K; Leong, KH; Mahdzir, MA; Sugiyama, D; Tanaka, Y1
Klinnikova, MG; Koldysheva, EV; Lushnikova, EL; Mzhelskaya, MM1
Alakurtti, S; Haavikko, R; Häkkinen, ST; Maiorova, N; Nygren, H; Oksman-Caldentey, KM; Rischer, H; Yli-Kauhaluoma, J1
Levdansky, VA; Maksimov, NG; Rubaylo, AI; Sursyakova, VV1
Abdullin, TI; Grigor Eva, LR; Khozyainova, SA; Mironov, VF; Nemtarev, AV; Salikhova, TI; Tsepaeva, OV1
Adámek, R; Borková, L; Frydrych, I; Gurská, S; Hajdúch, M; Jakubcová, N; Lišková, B; Medvedíková, M; Urban, M1
Li, G; Muhseen, ZT1
Kapustina, VI; Khodakov, AA; Molodykh, OP; Sorokina, IV; Vinogradova, EV1
Belosludtsev, KN; Dubinin, MV; Gudkov, SV; Ilzorkina, AI; Ishmuratov, GY; Khoroshavina, EI; Mikheeva, IB; Penkov, NV; Semenova, AA; Sharapov, VA; Vydrina, VA; Yashin, VA1
Cheng, J; Han, Y; Wang, J; Yang, X; Zhao, H1
Qiao, W; Wang, J; Yang, X; Zhao, H1
Dehaen, W; Dijkman, R; Jochmans, D; Krasniqi, B; Naesens, L; Nguyen, T; Stevaert, A; Thiel, V; Thomas, J; Van Loy, B; Vandeput, J; Voet, A1
Avram, S; Danciu, C; Dehelean, CA; Lombrea, A; Lugiņina, J; Pavel, IZ; Peipiņš, U; Scurtu, AD; Soica, C; Turks, M1
Chen, GT; Chu, CJ; Fan, BY; Huang, HL; Lu, YJ; Song, KN; Wu, YN1
Chu, Z; Feng, X; Liu, Y; Luo, Y; Ni, T; Wang, H; Zhu, M1
Guan, M; Hu, X; Li, B; Li, S; Liu, M; Liu, S; Ning, X; Song, G; Wan, X; Wang, J1

Reviews

1 review(s) available for oleanolic acid and betulonic acid

ArticleYear
Anticancer Potential of Betulonic Acid Derivatives.
    International journal of molecular sciences, 2021, Apr-01, Volume: 22, Issue:7

    Topics: Animals; Antineoplastic Agents; Humans; Oleanolic Acid

2021

Other Studies

47 other study(ies) available for oleanolic acid and betulonic acid

ArticleYear
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
    Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1

    Topics: 3T3-L1 Cells; Animals; Betulinic Acid; CHO Cells; Cricetinae; Cricetulus; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Pentacyclic Triterpenes; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship; Triterpenes

2010
Lupane-Type Triterpenes of Phoradendron vernicosum.
    Journal of natural products, 2017, 11-22, Volume: 80, Issue:11

    Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; HeLa Cells; Humans; KB Cells; MCF-7 Cells; Mexico; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phoradendron; Plant Components, Aerial; Plant Extracts; Plant Leaves; Triterpenes

2017
Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Animals; Antiviral Agents; Brain; Ethanol; Herpesviridae Infections; Herpesvirus 1, Human; Mice; Mice, Inbred BALB C; Oleanolic Acid; Plant Extracts; Plants, Toxic; Skin; Solvents; Toxicodendron; Viral Plaque Assay

1999
Development of C-20 modified betulinic acid derivatives as antitumor agents.
    Bioorganic & medicinal chemistry letters, 2001, Sep-03, Volume: 11, Issue:17

    Topics: Adenocarcinoma; Antineoplastic Agents; Betulinic Acid; Drug Screening Assays, Antitumor; Humans; Male; Melanoma; Oleanolic Acid; Pentacyclic Triterpenes; Prostatic Neoplasms; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured

2001
Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells.
    Cancer letters, 2002, Jan-10, Volume: 175, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Exons; Genes, p53; Humans; Kinetics; Oleanolic Acid; Reference Values; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2002
Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation products.
    Journal of natural products, 2002, Volume: 65, Issue:3

    Topics: Antigens, Viral; Antineoplastic Agents, Phytogenic; Biotransformation; Drug Screening Assays, Antitumor; Fungi; Humans; Japan; Lymphoma, B-Cell; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Stereoisomerism; Tetradecanoylphorbol Acetate; Triterpenes

2002
[Studies on chemical constituents in fruit of Eucalyptus globulus].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2002, Volume: 27, Issue:8

    Topics: Betulinic Acid; Eucalyptus; Fruit; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Triterpenes

2002
Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses.
    Fitoterapia, 2003, Volume: 74, Issue:5

    Topics: Antiviral Agents; Betulinic Acid; Dose-Response Relationship, Drug; Echovirus 6, Human; Herpesvirus 1, Human; Humans; Influenza A virus; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Triterpenes; Tumor Cells, Cultured; Viral Envelope Proteins

2003
[Qualitative and quantitative methods of betulonic acid in fruits of Liquidambar formosana].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2005, Volume: 30, Issue:15

    Topics: Chromatography, Thin Layer; Fruit; Liquidambar; Oleanolic Acid; Plants, Medicinal; Quality Control; Reproducibility of Results

2005
Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma.
    Bulletin of experimental biology and medicine, 2005, Volume: 140, Issue:3

    Topics: Animals; Liver; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Oleanolic Acid

2005
Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia.
    Archives of pharmacal research, 2006, Volume: 29, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Betulinic Acid; Cell Line, Tumor; Cell Proliferation; Humans; Inhibitory Concentration 50; Lignans; Oleanolic Acid; Pentacyclic Triterpenes; Plant Roots; Sesquiterpenes; Sesquiterpenes, Guaiane; Triterpenes

2006
Boc-lysinated-betulonic acid: a potent, anti-prostate cancer agent.
    Bioorganic & medicinal chemistry, 2006, Sep-15, Volume: 14, Issue:18

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Hydrophobic and Hydrophilic Interactions; Immunohistochemistry; In Vitro Techniques; Lysine; Male; Mice; Mice, Nude; Mitosis; Molecular Conformation; Oleanolic Acid; Prostatic Neoplasms; Solubility; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2006
Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica.
    Chemistry & biodiversity, 2005, Volume: 2, Issue:5

    Topics: Betulinic Acid; Coumarins; Euphorbiaceae; Humans; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Topoisomerase II Inhibitors; Triterpenes

2005
Biotransformation of betulinic and betulonic acids by fungi.
    Phytochemistry, 2007, Volume: 68, Issue:6

    Topics: Ascomycota; Betulinic Acid; Biotransformation; Colletotrichum; Fungi; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes

2007
Cardiomyocyte count in rat myocardium under the effect of antitumor agents cyclophosphamide and triterpenoids.
    Bulletin of experimental biology and medicine, 2007, Volume: 144, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Cyclophosphamide; Male; Myocardium; Myocytes, Cardiac; Oleanolic Acid; Rats; Rats, Wistar; Triterpenes

2007
Efficient synthesis of the first betulonic acid-acetylene hybrids and their hepatoprotective and anti-inflammatory activity.
    Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14

    Topics: Acetylene; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Edema; Enzymes; Inflammation; Male; Mice; Oleanolic Acid

2009
Anti-leishmanial activity of betulin derivatives.
    The Journal of antibiotics, 2010, Volume: 63, Issue:3

    Topics: Animals; Antiprotozoal Agents; Betulinic Acid; Cell Line; Cell Survival; Humans; Leishmania donovani; Macrophages; Mice; Oleanolic Acid; Oxidation-Reduction; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes

2010
Rapid access to new bioconjugates of betulonic acid via click chemistry.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Alkynes; Animals; Anti-Inflammatory Agents; Antioxidants; Antiviral Agents; Click Chemistry; Mice; Oleanolic Acid; Software; Structure-Activity Relationship

2011
Structure of the liver in mice with transplanted Lewis carcinoma during polychemotherapy and correction with betulonic acid and its derivatives.
    Bulletin of experimental biology and medicine, 2010, Volume: 150, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Drug Therapy, Combination; Hepatocytes; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Oleanolic Acid; Propionates

2010
Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits.
    Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7

    Topics: Betulinic Acid; Chromatography, High Pressure Liquid; Fluorescent Dyes; Food Analysis; Fruit; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid

2011
X-ray diffraction and infrared spectroscopy of N,N-dimethylformamide and dimethyl sulfoxide solvatomorphs of betulonic acid.
    Journal of pharmaceutical sciences, 2012, Volume: 101, Issue:12

    Topics: Antineoplastic Agents; Crystallography, X-Ray; Dimethyl Sulfoxide; Dimethylformamide; Models, Molecular; Oleanolic Acid; Spectrophotometry, Infrared

2012
A practical synthesis of betulonic acid using selective oxidation of betulin on aluminium solid support.
    Molecules (Basel, Switzerland), 2012, Oct-09, Volume: 17, Issue:10

    Topics: Aluminum; Oleanolic Acid; Oxidation-Reduction; Solid-Phase Synthesis Techniques; Triterpenes

2012
Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.
    Bulletin of experimental biology and medicine, 2012, Volume: 153, Issue:6

    Topics: Alanine Transaminase; Alkaline Phosphatase; Amides; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Count; Cell Proliferation; Chemical and Drug Induced Liver Injury; Ethanol; Female; Hepatocytes; L-Lactate Dehydrogenase; Liver; Oleanolic Acid; Rats

2012
Development and validation of a sensitive LC-MS-MS assay for the quantification of betulonic acid in rat plasma.
    Journal of chromatographic science, 2014, Volume: 52, Issue:3

    Topics: Animals; Chromatography, Liquid; Drug Stability; Liquidambar; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2014
Synthesis of triterpenoid triazine derivatives from allobetulone and betulonic acid with biological activities.
    Bioorganic & medicinal chemistry, 2014, Jul-01, Volume: 22, Issue:13

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Proliferation; DNA Viruses; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Conformation; Oleanolic Acid; RNA Viruses; Structure-Activity Relationship; Triazines; Triterpenes

2014
Simultaneous determination of six triterpenic acids in some Chinese medicinal herbs using ultrasound-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography with fluorescence detection.
    Journal of pharmaceutical and biomedical analysis, 2015, Mar-25, Volume: 107

    Topics: Betulinic Acid; Chromatography, High Pressure Liquid; Fluorescence; Limit of Detection; Liquid Phase Microextraction; Medicine, Chinese Traditional; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Solvents; Triterpenes; Ultrasonics; Ursolic Acid

2015
Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol.
    Bulletin of experimental biology and medicine, 2015, Volume: 158, Issue:3

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Female; Liver; Oleanolic Acid; Rats; Rats, Wistar

2015
Synthesis and biological evaluation of betulonic acid derivatives as antitumor agents.
    European journal of medicinal chemistry, 2015, Volume: 96

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; MCF-7 Cells; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured

2015
[Study on Chemical Composition of Phyllanthus emblica].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2015, Volume: 38, Issue:2

    Topics: Betulinic Acid; Gallic Acid; Oleanolic Acid; Pentacyclic Triterpenes; Phyllanthus emblica; Phytochemicals; Plants, Medicinal; Quercetin; Rutin; Triterpenes; Ursolic Acid

2015
Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives.
    Molecules (Basel, Switzerland), 2015, Dec-18, Volume: 20, Issue:12

    Topics: Antineoplastic Agents; Cell Survival; HeLa Cells; Humans; MCF-7 Cells; Oleanolic Acid; Spectroscopy, Fourier Transform Infrared

2015
Synthesis of novel lupane triterpenoid-indazolone hybrids with oxime ester linkage.
    Steroids, 2017, Volume: 117

    Topics: Betulinic Acid; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes

2017
Autoxidation Products of Betulonaldehyde.
    Journal of natural products, 2016, 10-28, Volume: 79, Issue:10

    Topics: Acetone; Air; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Hydrogen Peroxide; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Stereoisomerism; Triterpenes

2016
Induction of intrinsic apoptosis in leukaemia stem cells and in vivo zebrafish model by betulonic acid isolated from Walsura pinnata Hassk (Meliaceae).
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Mar-15, Volume: 26

    Topics: Animals; Apoptosis; Cell Survival; Humans; Leukemia; Malaysia; Meliaceae; Oleanolic Acid; Plant Bark; Stem Cells; Zebrafish

2017
Expression of Flk-1 and Cyclin D2 mRNA in the Myocardium of Rats with Doxorubicin-Induced Cardiomyopathy and after Treatment with Betulonic Acid Amide.
    Bulletin of experimental biology and medicine, 2017, Volume: 163, Issue:6

    Topics: Amides; Animals; Cardiomyopathies; Cardiotonic Agents; Cyclin D2; Doxorubicin; fms-Like Tyrosine Kinase 3; Gene Expression Regulation; Male; Myocardium; Myocytes, Cardiac; Oleanolic Acid; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction

2017
Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells.
    Planta medica, 2018, Volume: 84, Issue:9-10

    Topics: Biotransformation; Catharanthus; Cells, Cultured; Cyclodextrins; Glycosylation; Nicotiana; Oleanolic Acid; Oxidation-Reduction; Tandem Mass Spectrometry

2018
Combination of phase-solubility method and capillary zone electrophoresis to determine binding constants of cyclodextrins with practically water-insoluble compounds.
    Journal of pharmaceutical and biomedical analysis, 2018, Oct-25, Volume: 160

    Topics: Betulinic Acid; Cyclodextrins; Electrolytes; Electrophoresis, Capillary; Oleanolic Acid; Pentacyclic Triterpenes; Solubility; Temperature; Triterpenes; Water

2018
Synthesis, Anticancer, and Antibacterial Activity of Betulinic and Betulonic Acid C-28-Triphenylphosphonium Conjugates with Variable Alkyl Linker Length.
    Anti-cancer agents in medicinal chemistry, 2020, Volume: 20, Issue:3

    Topics: Alkanes; Anti-Bacterial Agents; Antineoplastic Agents; Antioxidants; Apoptosis; Betulinic Acid; Cytosol; Drug Design; Esters; Fluoresceins; Fluorescent Dyes; Gram-Positive Bacteria; Halogens; Humans; Mitochondria; Molecular Structure; Oleanolic Acid; Organophosphorus Compounds; PC-3 Cells; Pentacyclic Triterpenes; Structure-Activity Relationship; Superoxides; Triterpenes

2020
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid.
    European journal of medicinal chemistry, 2020, Jan-01, Volume: 185

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; Humans; Membrane Potential, Mitochondrial; Microsomes; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship; Terpenes; Thiazoles; Triterpenes

2020
Promising Terpenes as Natural Antagonists of Cancer: An In-Silico Approach.
    Molecules (Basel, Switzerland), 2019, Dec-30, Volume: 25, Issue:1

    Topics: Computer Simulation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Molecular Dynamics Simulation; Neoplasms; Oleanolic Acid; Principal Component Analysis; Proto-Oncogene Proteins c-mdm2; Structure-Activity Relationship; Terpenes; Triterpenes; Up-Regulation

2019
Ultrastructure of the Liver in Response to Cyclophosphamide and Triterpenoids.
    Bulletin of experimental biology and medicine, 2020, Volume: 168, Issue:3

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Hepatocytes; Liver; Mitochondria; Oleanolic Acid; Rats; Rats, Wistar; Triterpenes

2020
Effect of betulin and betulonic acid on isolated rat liver mitochondria and liposomes.
    Biochimica et biophysica acta. Biomembranes, 2020, 10-01, Volume: 1862, Issue:10

    Topics: Animals; Electron Transport; Energy Metabolism; Hydrogen Peroxide; Liposomes; Membrane Potential, Mitochondrial; Mitochondria, Liver; Oleanolic Acid; Oxidative Phosphorylation; Rats; Triterpenes

2020
Bioactive Natural Small Molecule-Tuned Coassembly of Photosensitive Drugs for Highly Efficient Synergistic and Enhanced Type I Photochemotherapy.
    ACS applied materials & interfaces, 2020, Sep-30, Volume: 12, Issue:39

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chlorophyllides; Density Functional Theory; Drug Carriers; Drug Screening Assays, Antitumor; Humans; Injections, Intravenous; Mammary Neoplasms, Experimental; Mice; Molecular Dynamics Simulation; Molecular Structure; Oleanolic Acid; Particle Size; Photochemotherapy; Photosensitizing Agents; Porphyrins; Surface Properties

2020
Paclitaxel and betulonic acid synergistically enhance antitumor efficacy by forming co-assembled nanoparticles.
    Biochemical pharmacology, 2020, Volume: 182

    Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Nanoparticles; Oleanolic Acid; Paclitaxel; Treatment Outcome; Xenograft Model Antitumor Assays

2020
Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease.
    Journal of medicinal chemistry, 2021, 05-13, Volume: 64, Issue:9

    Topics: Antiviral Agents; Cell Line; Coronavirus 229E, Human; Dose-Response Relationship, Drug; Endoribonucleases; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Models, Molecular; Oleanolic Acid; Viral Nonstructural Proteins; Virus Replication

2021
Biotransformation of Betulonic Acid by the Fungus
    Journal of natural products, 2021, 10-22, Volume: 84, Issue:10

    Topics: Acetylation; Animals; Anti-Inflammatory Agents; Biotransformation; Cell Line; Glycosylation; Hydroxylation; Mice; Molecular Structure; Neuroglia; Nitric Oxide; Oleanolic Acid; Rhizopus oryzae

2021
Betulonic Acid, as One of the Active Components of the
    Molecules (Basel, Switzerland), 2022, Feb-02, Volume: 27, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Celastrus; Cell Line, Tumor; Cytoskeleton; Humans; Neoplasm Invasiveness; Oleanolic Acid; Stomach Neoplasms

2022
Discovery and structural optimization of 3-O-β-Chacotriosyl betulonic acid saponins as potent fusion inhibitors of Omicron virus infections.
    Bioorganic chemistry, 2023, Volume: 131

    Topics: COVID-19; HIV Fusion Inhibitors; Humans; Oleanolic Acid; Saponins; SARS-CoV-2; Virus Diseases

2023