oleanolic acid has been researched along with betulinic acid in 130 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (3.08) | 18.2507 |
| 2000's | 42 (32.31) | 29.6817 |
| 2010's | 73 (56.15) | 24.3611 |
| 2020's | 11 (8.46) | 2.80 |
| Authors | Studies |
|---|---|
| Assefa, H; Nimrod, A; Sindelar, R; Walker, L | 1 |
| Cosentino, LM; Hashimoto, A; Ikeshiro, Y; Kashiwada, Y; Lee, KH; Nagao, T; Okabe, H | 1 |
| Hata, K; Hori, K; Takahashi, S | 1 |
| Johnson, RK; Kingston, DG; Prakash Chaturvedula, VS; Schilling, JK | 1 |
| Gao, Z; Hecht, SM; Jones, SH; Kingston, DG; Prakash Chaturvedula, VS | 1 |
| Franzblau, SG; Gu, JQ; Montenegro, G; Timmermann, BN; Wang, Y | 1 |
| Ando, M; Fu, L; Hasegawa, T; Hirose, K; Kataoka, T; Kiuchi, M; Li, N; Mitsui, T; Oka, S; Sakai, J; Wang, J; Zhang, S; Zhao, M | 1 |
| Habib-Jiwan, JL; Hoet, S; Muccioli, GG; Opperdoes, FR; Pieters, L; Quetin-Leclercq, J | 1 |
| Dedkova, LM; Gao, Z; Hecht, SM; Maloney, DJ | 1 |
| Alexacou, KM; Cheng, K; Gimisis, T; Hao, J; Hayes, JM; Leonidas, DD; Liu, J; Ni, P; Oikonomakos, NG; Sun, H; Wen, X; Zhang, L; Zhang, P; Zographos, SE | 1 |
| Chadwick, LR; Franzblau, SG; Jaki, BU; Lankin, DC; Pauli, GF; Wang, Y; Zhang, F | 1 |
| Gauthier, C; Girard-Lalancette, K; Legault, J; Mshvildadze, V; Pichette, A | 1 |
| Bae, K; Ha, do T; Ngoc, TM; Nhiem, NX; Thu, NB; Tuan, DT; Yim, N | 1 |
| Auwerx, J; Boudjelal, G; Genet, C; Lobstein, A; Saladin, R; Schmidt, C; Schoonjans, K; Souchet, M; Strehle, A; Wagner, A | 1 |
| Chen, J; Chen, L; Cheng, K; Gong, Y; Hao, J; Jiang, H; Li, H; Li, L; Liang, Z; Liu, H; Liu, J; Luo, C; Sun, H; Wen, X; Zhang, L; Zhang, P; Zhang, X; Zheng, M; Zhu, X | 1 |
| El-Kabbani, O; Endo, S; Hara, A; Iinuma, M; Matsunaga, T; Soda, M; Tajima, K; Takemura, M; Zhao, HT | 1 |
| Aquino, R; Capasso, A; Festa, M; Mencherini, T; Picerno, P; Russo, P | 1 |
| Gatbonton-Schwager, TN; Letterio, JJ; Tochtrop, GP | 1 |
| Chin, YW; Jee, JG; Jeong, YJ; Keum, YS; Kim, Y; Lee, J; Lee, JM; Yu, MS | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Cai, G; Franzblau, SG; Jaki, BU; Lankin, DC; Pauli, GF; Qiu, F | 1 |
| Kiem, PV; Kim, ES; Kim, N; Kim, S; Kim, SH; Kim, YH; Koh, YS; Lee, HY; Minh, CV; Nhiem, NX; Park, S | 1 |
| Chen, K; Huang, X; Peng, Y; Qiu, Y; Shi, Y; Sun, D; Wang, H; Wang, Q; Xiao, S; Yu, F; Yu, M; Zhang, C; Zhang, L; Zhang, Z; Zhao, C; Zheng, Y; Zhou, D; Zhu, L | 1 |
| Feng, Y; Mei, Z; Wang, C; Yang, G; Yang, J; Yang, X; Zhao, P; Zhou, Q | 1 |
| Cai, L; Jiang, S; Jiang, X; Li, J; Li, X; Liang, G; Liu, K; Lu, L; Na, H; Wang, C; Wang, Q; Xu, X; Yu, F; Zhang, T; Zhang, Z; Zheng, B | 1 |
| Ba Thi, C; D'hooghe, M; Dang Thi, TA; Doan Duy, T; Kim Tuyet, NT; Pham The, C; Thanh Nguyen, H; Van Nguyen, T | 1 |
| Ahn, HC; Cho, SC; Choi, BY; Fei, X; Keum, YS; Kim, HJ; Lee, K; Seo, SY | 1 |
| Csuk, R; Heller, L; Wiemann, J | 1 |
| Brandner, JM; Merfort, I; Schmidt, G; Templin, MF; Thomas, M; Wardecki, T; Werner, P | 1 |
| Csuk, R; Heller, L; Kuhfs, J; Sommerwerk, S | 1 |
| Si, L; Wang, Q; Xiao, S; Zhang, L; Zhang, Y; Zhou, D; Zhou, X | 1 |
| Csuk, R; Heller, L; Kerzig, C; Kramell, AE; Sommerwerk, S | 1 |
| Wang, WW; Xu, SH; Yu, BY; Zhang, C; Zhang, J; Zhang, YY; Zhao, YZ | 1 |
| Bailon-Moscoso, N; Castillo-Veintimilla, P; Romero-Benavides, JC; Ruano, AL; Silva-Rivas, R; Vivanco-Jaramillo, S | 1 |
| Alcaro, S; Corona, A; Cottiglia, F; Distinto, S; Floris, C; Fois, B; Maccioni, E; Malpure, NV; Meleddu, R; Sonar, VP; Tramontano, E | 1 |
| Alho, DPS; Figueiredo, SAC; Gonçalves, BMF; Leal, AS; Mendes, VIS; Salvador, JAR; Silvestre, SM; Valdeira, AS | 1 |
| Cao, G; Chang, Y; Chen, D; He, X; Huang, X; Liu, J; Luo, H; Ni, S; Shen, Q; Sun, H; Wang, P; Wen, X; Zhou, H | 1 |
| Dong, YS; Sun, WL; Wen, C; Xing, Y; Xiu, ZL; Yu, XX; Zhang, BW | 1 |
| García-Cámara, I; Moo-Puc, RE; Peraza-Sánchez, SR; Torres-Tapia, LW; Valencia-Chan, LS | 1 |
| Baikova, IP; Giniyatullina, GV; Kataev, VE; Kazakova, OB; Lopatina, TV; Medvedeva, NI; Smirnova, IE | 1 |
| Anaya-Eugenio, GD; Burdette, JE; Chai, HB; Czarnecki, AA; de Blanco, EJC; Kinghorn, AD; Ninh, TN; Ren, Y; Soejarto, DD; Yuan, C | 1 |
| Csuk, R; Fischer, L; Kahnt, M; Sommerwerk, S; Wiemann, J | 1 |
| Efdi, M; Itoh, T; Katsurayama, K; Koketsu, M; Ninomiya, M | 1 |
| Appendino, G; Bellido, ML; Calzado, MA; Caprioglio, D; Cruz, C; Galera, N; Jinénez, C; Minassi, A; Muñoz, E; Prados, ME; Rogati, F | 1 |
| Borkova, L; Hodon, J; Kazakova, A; Pokorny, J; Urban, M | 1 |
| Brandes, B; Csuk, R; Fischer, L; Hoenke, S | 1 |
| Buckle, R; Eldridge, GR; Ellis, M; Garo, E; Hu, JF; Huang, Z; Lawrence, JA; Norman, VL; Rathinavelu, S; Starks, CM; Williams, RB | 1 |
| Awale, S; Dibwe, DF; Kim, MJ; Omar, AM; Sun, S; Tawila, AM; Toyooka, N; Ueda, JY | 1 |
| Chen, C; Cheng, K; Dai, L; Hu, K; Li, H; Liu, L; Sun, H; Wen, X; Xu, Q; Yuan, H | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Brum, RL; Cechinel Filho, V; Cruz, AB; Cruz, RB; Ferrari, F; Hess, SC; Honda, NK; Messana, I; Moretto, E; Yunes, RA | 1 |
| Giner, RM; Máñez, S; Recio, MC; Ríos, JL | 1 |
| Kirby, GC; Simmonds, MS; Steele, JC; Warhurst, DC | 1 |
| Kim, YK; Ryu, SY; Yoon, SK | 1 |
| Kim, DS; Kim, JY; Koo, HM | 1 |
| Baumann, D; Ciesielski, S; Dittmann, K; Graf, H; Hamburger, M; Melzig, MF; Riese, U; Wegner, C | 1 |
| Chen, B; Mi, HM; Wu, YT; Xing, WX; Yang, GJ; Zhu, M | 1 |
| Boreko, EI; Flekhter, OB; Nikolaeva, SN; Pavlova, NI; Savinova, OV | 1 |
| Baglin, I; Cavé, C; Lacaille-Dubois, MA; Mitaine-Offer, AC; Nour, M; Tan, K | 1 |
| Hamburger, M; Knorr, R | 1 |
| Doubek, DL; Duke, JA; Herald, DL; Pettit, GR; Pinilla, V; Zhang, Q | 1 |
| Bérangère, C; Caussarieu, N; Lafosse, M; Morin, P; Morin-Allory, L | 1 |
| Becker, H; Hostanska, K; Scher, JM; Urech, K | 1 |
| Im, KR; Jeong, TS; Lee, WS; Park, YD; Sung, ND | 1 |
| Kong, LY; Li, WJ; Lu, J; Xu, LL | 1 |
| Choi, SU; Choi, SZ; Lee, KR; Yang, MC | 1 |
| Kuiate, JR; Mouokeu, S; Tane, P; Wabo, HK | 1 |
| Tanaka, R; Wada, S | 1 |
| Benny, TK; Manoharan, KP; Song, FJ; Yang, D | 1 |
| Bastos, DZ; de Jesus, DA; de Oliveira, BH; Pimentel, IC | 1 |
| Jäger, S; Pfüller, U; Scheffler, A; Winkler, K | 1 |
| Chang, CS; Chang, YS; Chao, DC; Chen, JC; Ho, TY; Hsiang, CY; Li, CC; Wu, SL | 1 |
| Beng, VP; Etoa, FX; Kuete, V; Lall, N; Mbaveng, AT; Metuno, R; Meyer, JJ; Ngadjui, BT; Ngameni, B; Wabo, GF | 1 |
| Bremner, JB; Chokchaisiri, R; Suksamrarn, A; Tanachatchairatana, T | 1 |
| Hao, J; Sun, H; Wen, X; Zhang, P | 1 |
| Duval, RE; Finance, C; Fontanay, S; Grare, M; Mayer, J | 1 |
| Cui, BS; Li, HY; Li, S; Shi, Y; Yuan, Y | 1 |
| Durić, K; E Kovac-Besović, E; Kalodera, Z; Sofić, E | 1 |
| Hu, LH; Xu, JQ | 1 |
| Jäger, S; Kopp, T; Laszczyk, MN; Scheffler, A; Trojan, H | 1 |
| Ahmad, AS; Mansour, AI; Nafady, AM; Ramadan, MA | 1 |
| Alakurtti, S; Bergström, P; Jaffe, CL; Sacerdoti-Sierra, N; Yli-Kauhaluoma, J | 1 |
| Chen, XG; Cui, BS; Li, S; Shang, XY; Shi, JG; Shi, Y; Yang, YC; Yuan, Y | 1 |
| Cai, Q; Feng, X; Liu, YQ | 1 |
| Chen, CH; Huang, L; Kuo, RY; Lee, KH; Morris-Natschke, SL; Qian, K | 1 |
| Christensen, SB; Hansen, EW; Jäger, AK; Moesby, L; Saaby, L | 1 |
| Chen, YS; Lin, XY; Xie, JM; Yao, H; Zhang, YH | 1 |
| Li, GL; Song, CH; Suo, YR; Xia, L; You, JM; Zheng, J | 1 |
| Hu, HB; Jian, YF; Liu, JX; Zheng, XD; Zhu, JH | 1 |
| Fukushima, EO; Mizutani, M; Muranaka, T; Ohyama, K; Ono, E; Saito, K; Seki, H; Umemoto, N | 1 |
| Nielsen, CH; Saaby, L | 1 |
| Gao, L; Lin, CZ; Zhao, ZX; Zhu, CC | 1 |
| Dzubak, P; Hajduch, M; Sarek, J; Urban, M; Vlk, M | 1 |
| David, JM; David, JP; e Silva, Mde L; Fontana, R; Lima, LS; Reis, PS; Santos, RA; Silva, LC | 1 |
| Bruni, R; Caligiani, A; Malavasi, G; Marseglia, A; Palla, G; Tognolini, M | 1 |
| Chung, LY; Chung, PY; Navaratnam, P | 2 |
| Arnason, JT; Cal, V; Cayer, C; Durst, T; Kent, P; Merali, Z; Mullally, M; Poveda Álvarez, L; Puniani, E; Sánchez-Vindas, P | 1 |
| He, QQ; Ma, CM; Ma, JN; Yang, L; Zhang, JY | 1 |
| Liu, JS; Wang, G; Wang, GK; Xu, YS | 1 |
| Chen, G; Hu, N; Li, G; Liu, D; Liu, S; Suo, Y; Wu, H; You, J | 1 |
| Gaikwad, NB; Kshirsagar, PR; Nimbalkar, MS; Pai, SR | 1 |
| Hu, HJ; Liu, Q; Wang, ZT; Yang, L; Yang, YB | 1 |
| Huang, GQ; Li, B; Lu, RM; Wei, JH; Zhong, ZG | 1 |
| Fukuhara, S; Hiramatsu, R; Kataoka, T; Mitsuda, S; Yokomichi, T | 1 |
| Li, QR; Qiu, Z; Wei, Q; Xu, F; Yin, H | 1 |
| Lu, MH; Xiao, W | 1 |
| Duarte, MF; Oliveira, PJ; Silva, FS | 1 |
| Hegde, HV; Joshi, RK; Kholkute, SD; Pai, SR; Upadhya, V | 1 |
| Fu, HZ; Yan, QW; Zhang, TX; Zhong, RJ; Zhou, GP | 1 |
| Baranovsky, AV; Khlebnicova, TS; Kumpiņš, V; Lakhvich, FA; Mieriņa, I; Peipiņš, U; Piven, YA; Rāviņa, I; Rijkure, I; Shishkina, SV; Tetere, Z; Turks, M; Zicāne, D | 1 |
| Kocjan, R; Luchowski, P; Pucek, K; Sowa, I; Szymczak, G; Wójciak-Kosior, M | 1 |
| Günther, G; Morales, J; Rodríguez, L; Valdés, K | 1 |
| Bag, BG; Majumdar, R | 1 |
| Das, V; Ghosh, S; Giri, B; Kumar, A; Mandal, A; Mukhopadhyay, S; Sarkar, M | 1 |
| Boral, S; Börno, S; Delebinski, CI; Eggert, A; Jäger, S; Meierhofer, D; Seifert, G; Timmermann, B; Twardziok, M | 1 |
| Abouem A Zintchem, A; Alex De Théodore, A; Christian G, B; Dieudonné Emmanuel, P; Dominique Serge, NB; Ebeh Messanga, R; Esther Del Florence, MN; Koert, U; Maximilienne Ascension, N; Norbert, MNI; Patrick Hervé, BD | 1 |
| Ahn, SJ; Bang, IS; Cho, E; Choi, MH; Kim, JM; Kook, JK; Lim, YK; Park, SN | 1 |
| Henao, IC; Pereañez, JA; Preciado, LM; Rey-Suárez, P | 1 |
| Ren, T; Xu, Z | 1 |
| Levdansky, VA; Maksimov, NG; Rubaylo, AI; Sursyakova, VV | 1 |
| Kai, H; Matsuno, K; Mutoh, J; Nakamura, S; Nakashima, K; Tojoh, Y; Wada, M | 1 |
| Chua, LK; Chye, SM; Koh, RY; Lim, CL; Ling, APK | 1 |
| Forino, M; Gambuti, A; Moio, L | 1 |
| Cui, H; Jin, C; Jin, M; Li, G; Wang, J; Wang, R; Ye, C; Zhou, W; Zhou, Y | 1 |
| Chung, PY | 1 |
| Abdullin, TI; Grigor Eva, LR; Khozyainova, SA; Mironov, VF; Nemtarev, AV; Salikhova, TI; Tsepaeva, OV | 1 |
| Gubaidullin, RR; Khalitova, RR; Nedopekina, DA; Spivak, AY | 1 |
| Li, Y; Liang, T; Ma, H; Tian, H; Xiao, J; Xu, Z; Yang, J; Yin, J; Zhan, Y | 1 |
| Li, Y; Qu, Z; Sun, L; Wang, S; Xiao, J; Yang, J; Yin, J; Zhan, Y | 1 |
10 review(s) available for oleanolic acid and betulinic acid
| Article | Year |
|---|---|
Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies.
Topics: Anthelmintics; Humans; Medicine, Traditional; Phytotherapy; Plants, Medicinal | 2017 |
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.
Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Indolequinones; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triterpenes | 2017 |
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Biomedical Research; Cell Proliferation; Drug Design; Humans; Neoplasms; Triterpenes; Viruses | 2019 |
A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.
Topics: Anti-HIV Agents; Antineoplastic Agents; Betulinic Acid; HIV-1; HT29 Cells; Humans; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2003 |
[Drug discovery based on classic natural products].
Topics: Animals; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Berberine; Betulinic Acid; Biological Products; Camptothecin; Drug Discovery; Humans; Hypoglycemic Agents; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes; Vinblastine | 2009 |
Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?
Topics: Anti-Inflammatory Agents; Betulinic Acid; Body Weight; Diabetes Mellitus, Type 2; Dietary Supplements; Hypoglycemic Agents; Illusions; Insulin Resistance; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes | 2016 |
Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments.
Topics: Animals; Antineoplastic Agents; Betulinic Acid; Biological Availability; Drug Delivery Systems; Drug Liberation; Humans; Nanocapsules; Neoplasms; Oleanolic Acid; Pentacyclic Triterpenes; Solubility; Triterpenes; Unilamellar Liposomes; Ursolic Acid; Water | 2016 |
Self-assembly of Renewable Nano-sized Triterpenoids.
Topics: Betulinic Acid; Cyclization; Gels; Glycyrrhetinic Acid; Microscopy, Electron, Scanning; Nanoparticles; Oleanolic Acid; Pentacyclic Triterpenes; Plants; Terpenes; Triterpenes | 2017 |
Anticancer Potential of Syzygium Species: a Review.
Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Chalcones; Humans; Oleanolic Acid; Pentacyclic Triterpenes; Phenols; Phytochemicals; Plants, Medicinal; Syzygium; Triterpenes | 2019 |
Novel targets of pentacyclic triterpenoids in Staphylococcus aureus: A systematic review.
Topics: Anti-Bacterial Agents; Betulinic Acid; Biofilms; Drug Resistance, Multiple, Bacterial; Oleanolic Acid; Pentacyclic Triterpenes; Plants; Secondary Metabolism; Staphylococcal Infections; Staphylococcus aureus; Triterpenes | 2020 |
120 other study(ies) available for oleanolic acid and betulinic acid
| Article | Year |
|---|---|
Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid.
Topics: Antineoplastic Agents; Apoptosis; Complement Inactivator Proteins; DNA Fragmentation; Drug Evaluation, Preclinical; Humans; Melanoma; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.
Topics: Anti-HIV Agents; Cell Line; HIV-1; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes; Ursolic Acid | 2000 |
Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.
Topics: Animals; Apoptosis; Betulinic Acid; Cell Differentiation; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Mice; Molecular Structure; Oxidation-Reduction; Pentacyclic Triterpenes; Pyridinium Compounds; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured | 2002 |
New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Female; Guyana; Humans; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plant Stems; Plants, Medicinal; Rubiaceae; Stereoisomerism; Triterpenes; Tumor Cells, Cultured | 2003 |
A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.
Topics: Base Sequence; Betulinic Acid; Chrysobalanaceae; DNA Polymerase beta; Enzyme Inhibitors; Lyases; Mexico; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Plant Stems; Plants, Medicinal; Triterpenes | 2003 |
Constituents of Senecio chionophilus with potential antitubercular activity.
Topics: Antitubercular Agents; Chile; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Toxic; Senecio; Sesquiterpenes; Stereoisomerism | 2004 |
Three new triterpenes from Nerium oleander and biological activity of the isolated compounds.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Screening Assays, Antitumor; Humans; Intercellular Adhesion Molecule-1; Japan; Models, Biological; Molecular Structure; Nerium; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Triterpenes; Tumor Cells, Cultured | 2005 |
Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.
Topics: Animals; Benin; Cell Line, Tumor; Molecular Structure; Plant Leaves; Plants, Medicinal; Sterols; Stigmasterol; Structure-Activity Relationship; Strychnos; Triterpenes; Trypanocidal Agents; Trypanosoma brucei brucei | 2007 |
Inhibitors of DNA polymerase beta: activity and mechanism.
Topics: Bleomycin; Catalysis; Cell Line, Tumor; Cell Survival; Coumarins; DNA; DNA Polymerase beta; DNA Repair Enzymes; Enzyme Inhibitors; Humans; Molecular Structure; Schiff Bases; Structure-Activity Relationship; Substrate Specificity | 2008 |
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Topics: Adenosine Monophosphate; Allosteric Site; Animals; Binding Sites; Crystallography, X-Ray; Glycogen Phosphorylase; Hypoglycemic Agents; Kinetics; Models, Molecular; Muscles; Oleanolic Acid; Pentacyclic Triterpenes; Protein Binding; Protein Conformation; Rabbits; Stereoisomerism; Structure-Activity Relationship; Triterpenes | 2008 |
Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.
Topics: Animals; Antitubercular Agents; Biological Products; Chlorocebus aethiops; Inhibitory Concentration 50; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Triterpenes; Ursolic Acid; Vero Cells | 2008 |
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
Topics: Animals; Cell Line, Tumor; Cell Membrane Permeability; Erythrocytes; Hemolysis; Humans; Oleanolic Acid; Saponins; Sheep; Triterpenes | 2009 |
Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.
Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Glucose; Glycogen; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoglycemic Agents; Insulin Resistance; Paeonia; Phosphorylation; Terpenes; Triterpenes | 2009 |
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Topics: 3T3-L1 Cells; Animals; Betulinic Acid; CHO Cells; Cricetinae; Cricetulus; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Pentacyclic Triterpenes; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship; Triterpenes | 2010 |
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
Topics: Animals; Enzyme Inhibitors; Glycogen Phosphorylase, Muscle Form; Models, Molecular; Molecular Conformation; Muscle, Skeletal; Pentacyclic Triterpenes; Quantitative Structure-Activity Relationship; Rabbits; Stereoisomerism | 2011 |
Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Antineoplastic Agents, Phytogenic; Drug Resistance, Neoplasm; HeLa Cells; HT29 Cells; Humans; Mitomycin; Models, Molecular; Molecular Structure; Mutation; Oleanolic Acid; Pentacyclic Triterpenes | 2011 |
Triterpenoid constituents from the roots of Paeonia rockii ssp. rockii.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Biphenyl Compounds; Caspase Inhibitors; Drug Screening Assays, Antitumor; HEK293 Cells; HT29 Cells; Humans; Italy; Oleanolic Acid; Paeonia; Pentacyclic Triterpenes; Picrates; Plant Roots; Triterpenes | 2011 |
Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Dose-Response Relationship, Drug; Heme Oxygenase-1; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 1; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Triterpenes | 2012 |
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.
Topics: Adenosine Triphosphate; Antiviral Agents; Apigenin; Breast; Cell Line; Cell Proliferation; Colorimetry; DNA; DNA Helicases; Epithelial Cells; Female; Flavonoids; Fluorescence Resonance Energy Transfer; Hepacivirus; Humans; Hydrolysis; Inhibitory Concentration 50; Kinetics; Methyltransferases; RNA Helicases; Severe acute respiratory syndrome-related coronavirus; Species Specificity; Viral Nonstructural Proteins; Viral Proteins | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.
Topics: Alaska; Antitubercular Agents; Biological Products; Fruit; Humans; Models, Biological; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Oplopanax; Quantitative Structure-Activity Relationship; Triterpenes | 2013 |
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
Topics: Animals; Anti-Inflammatory Agents; Bone Marrow Cells; Cytokines; Dendritic Cells; Diarylheptanoids; Flavonoids; Glycosides; Inhibitory Concentration 50; Interleukin-12 Subunit p40; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Plant Leaves; Plant Stems; Stereoisomerism; Tumor Necrosis Factor-alpha; Viscum album | 2013 |
Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Cytotoxins; HEK293 Cells; Hemolytic Agents; Hepacivirus; Humans; Oleanolic Acid; Rabbits; Structure-Activity Relationship; Virus Internalization | 2013 |
Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities.
Topics: Animals; Cell Line; Chalcones; Crystallography, X-Ray; Eucalyptus; Glucose Transporter Type 4; Models, Molecular; Molecular Structure; Plant Leaves; Rats; Xanthenes | 2014 |
Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.
Topics: Amino Acid Sequence; Antiviral Agents; Cell Line; Cell Line, Tumor; Cell Survival; Enfuvirtide; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV-1; Humans; Models, Chemical; Models, Molecular; Molecular Sequence Data; Molecular Structure; Peptide Fragments; Protein Structure, Secondary; Sapogenins; Structure-Activity Relationship | 2014 |
Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates.
Topics: Araliaceae; Cytotoxins; Drug Evaluation, Preclinical; Eleutherococcus; Esters; Hep G2 Cells; Humans; Plant Extracts; Triazoles; Triterpenes; Zidovudine | 2014 |
Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1.
Topics: Binding, Competitive; Drug Discovery; Humans; Isocitrate Dehydrogenase; MCF-7 Cells; Molecular Structure; Mutation; Recombinant Proteins; Structure-Activity Relationship; Xanthones | 2015 |
Targeting cancer cells with oleanolic and ursolic acid derived hydroxamates.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Oleanolic Acid; Structure-Activity Relationship; Triterpenes; Ursolic Acid | 2016 |
Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors.
Topics: Betula; Cytokines; Diabetes Mellitus; Female; Fibroblasts; Humans; Interleukin-6; Interleukin-8; Keratinocytes; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Plant Bark; rho GTP-Binding Proteins; Triterpenes; Wound Healing | 2016 |
Urea derivates of ursolic, oleanolic and maslinic acid induce apoptosis and are selective cytotoxic for several human tumor cell lines.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Mice; NIH 3T3 Cells; Oleanolic Acid; Structure-Activity Relationship; Triterpenes; Ursolic Acid | 2016 |
Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors.
Topics: alpha-Cyclodextrins; Animals; Antiviral Agents; Dogs; Hepacivirus; Humans; Madin Darby Canine Kidney Cells; Triterpenes; Virus Internalization | 2016 |
Rhodamine B conjugates of triterpenoic acids are cytotoxic mitocans even at nanomolar concentrations.
Topics: Animals; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mitochondria; NIH 3T3 Cells; Rhodamines; Structure-Activity Relationship; Triterpenes | 2017 |
Microbial hydroxylation and glycosylation of pentacyclic triterpenes as inhibitors on tissue factor procoagulant activity.
Topics: Glycosylation; Humans; Hydroxylation; Structure-Activity Relationship; Thromboplastin; Triterpenes | 2017 |
Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase.
Topics: Amides; Anti-HIV Agents; Binding Sites; Caffeic Acids; Coumaric Acids; DNA-Directed DNA Polymerase; Esters; HIV Reverse Transcriptase; Plant Extracts; Ribonuclease H, Human Immunodeficiency Virus; Structure-Activity Relationship; Triterpenes | 2017 |
Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors.
Topics: Animals; Cholesterol Ester Transfer Proteins; Dose-Response Relationship, Drug; Drug Discovery; Esters; Guinea Pigs; Humans; Mice; Mice, Transgenic; Molecular Structure; Structure-Activity Relationship; Triterpenes | 2017 |
Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose.
Topics: Acarbose; alpha-Amylases; alpha-Glucosidases; Drug Synergism; Inhibitory Concentration 50; Kinetics; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes | 2017 |
Lupane-Type Triterpenes of Phoradendron vernicosum.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; HeLa Cells; Humans; KB Cells; MCF-7 Cells; Mexico; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phoradendron; Plant Components, Aerial; Plant Extracts; Plant Leaves; Triterpenes | 2017 |
Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes.
Topics: Antitubercular Agents; Azepines; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Triterpenes | 2018 |
Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Molecular Conformation; NF-kappa B; Plant Extracts; Plant Leaves; Structure-Activity Relationship; Syzygium; Triterpenes; Ursolic Acid | 2018 |
Transformation of asiatic acid into a mitocanic, bimodal-acting rhodamine B conjugate of nanomolar cytotoxicity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Structure; NIH 3T3 Cells; Pentacyclic Triterpenes; Structure-Activity Relationship | 2018 |
Sentulic acid isolated from Sandoricum koetjape Merr attenuates lipopolysaccharide and interferon gamma co-stimulated nitric oxide production in murine macrophage RAW264 cells.
Topics: Animals; Cyclooxygenase 2; Down-Regulation; Interferon-gamma; Interleukin-6; Lipopolysaccharides; Macrophages; Meliaceae; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptors; Triterpenes; Tumor Necrosis Factor-alpha | 2018 |
Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors.
Topics: Enzyme Inhibitors; HEK293 Cells; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; NF-kappa B; Triterpenes | 2018 |
Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids.
Topics: Antineoplastic Agents; Boron Compounds; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; MCF-7 Cells; Molecular Structure; Structure-Activity Relationship; Triterpenes | 2020 |
Optimized plant compound with potent anti-biofilm activity across gram-negative species.
Topics: Amines; Anti-Bacterial Agents; Biofilms; Dose-Response Relationship, Drug; Gram-Negative Bacteria; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship | 2020 |
Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line.
Topics: Antineoplastic Agents, Phytogenic; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Egypt; Humans; Molecular Structure; Myrtaceae; Pancreatic Neoplasms; Structure-Activity Relationship; Terpenes; Tumor Microenvironment | 2020 |
Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Glycyrrhizic Acid; Humans; Interleukin-6; Liver; Macrophages; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Oleanolic Acid; Pentacyclic Triterpenes; Phosphorylation; Sapogenins; Saponins; Tumor Necrosis Factor-alpha | 2021 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Antibacterial activity and phytochemical analysis of Vochysia divergens (Vochysiaceae).
Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Betulinic Acid; Brazil; Escherichia coli; Magnetic Resonance Spectroscopy; Medicine, Traditional; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Plant Stems; Sitosterols; Spectrophotometry, Infrared; Staphylococcus aureus; Triterpenes | 1995 |
Effect of selected triterpenoids on chronic dermal inflammation.
Topics: Animals; Anti-Inflammatory Agents; Betulinic Acid; Dermatitis, Contact; Dexamethasone; Drug Evaluation, Preclinical; Female; Mice; Oleanolic Acid; Pentacyclic Triterpenes; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 1997 |
In vitro and in vivo evaluation of betulinic acid as an antimalarial.
Topics: Animals; Antimalarials; Betulinic Acid; Disease Models, Animal; Euphorbiaceae; Malaria; Mice; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Plant Roots; Plasmodium berghei; Plasmodium falciparum; Random Allocation; Structure-Activity Relationship; Triterpenes; Ursolic Acid | 1999 |
Cytotoxic triterpenes from stem bark of Physocarpus intermedius.
Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Humans; Magnetic Resonance Spectroscopy; Oleanolic Acid; Pentacyclic Triterpenes; Plant Stems; Rosales; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2000 |
Development of C-20 modified betulinic acid derivatives as antitumor agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Betulinic Acid; Drug Screening Assays, Antitumor; Humans; Male; Melanoma; Oleanolic Acid; Pentacyclic Triterpenes; Prostatic Neoplasms; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured | 2001 |
Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities.
Topics: Antioxidants; Betulinic Acid; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Esters; Fatty Acids, Essential; Free Radical Scavengers; gamma-Linolenic Acid; Leukocyte Elastase; Linoleic Acids; Mass Spectrometry; Oenothera biennis; Oleanolic Acid; Pentacyclic Triterpenes; Plant Oils; Triterpenes | 2002 |
[Studies on chemical constituents in fruit of Eucalyptus globulus].
Topics: Betulinic Acid; Eucalyptus; Fruit; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Triterpenes | 2002 |
Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses.
Topics: Antiviral Agents; Betulinic Acid; Dose-Response Relationship, Drug; Echovirus 6, Human; Herpesvirus 1, Human; Humans; Influenza A virus; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Triterpenes; Tumor Cells, Cultured; Viral Envelope Proteins | 2003 |
Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil.
Topics: Anti-Inflammatory Agents; Betulinic Acid; Caffeic Acids; Chromatography, High Pressure Liquid; Esters; Fatty Acids, Essential; Free Radical Scavengers; gamma-Linolenic Acid; Linoleic Acids; Oenothera biennis; Oleanolic Acid; Pentacyclic Triterpenes; Plant Oils; Triterpenes | 2004 |
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Brazil; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Lecythidaceae; Leukemia P388; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pentacyclic Triterpenes; Phenols; Plants, Medicinal; Trees; Triterpenes | 2004 |
Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection.
Topics: Betulinic Acid; Carbon; Chromatography, Liquid; Glycyrrhetinic Acid; Light; Models, Chemical; Models, Molecular; Oleanolic Acid; Pentacyclic Triterpenes; Scattering, Radiation; Time Factors; Triterpenes; Ultraviolet Rays; Ursolic Acid | 2004 |
Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Erythroblasts; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Triterpenes; Ursolic Acid; Viscum | 2005 |
Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ.
Topics: Animals; Betulinic Acid; Cell Line; Enzyme Inhibitors; Humans; Lycopus; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2; Triterpenes; Ursolic Acid | 2006 |
[Studies on the chemical constituents in root of Coleus forskohlii].
Topics: Betulinic Acid; Coleus; Diterpenes; Oleanolic Acid; Pentacyclic Triterpenes; Plant Roots; Plants, Medicinal; Triterpenes | 2005 |
Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia.
Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Betulinic Acid; Cell Line, Tumor; Cell Proliferation; Humans; Inhibitory Concentration 50; Lignans; Oleanolic Acid; Pentacyclic Triterpenes; Plant Roots; Sesquiterpenes; Sesquiterpenes, Guaiane; Triterpenes | 2006 |
Antidermatophytic triterpenoids from Syzygium jambos (L.) Alston (Myrtaceae).
Topics: Antifungal Agents; Betulinic Acid; Microbial Sensitivity Tests; Microsporum; Mitosporic Fungi; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Syzygium; Trichophyton; Triterpenes | 2007 |
Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica.
Topics: Betulinic Acid; Coumarins; Euphorbiaceae; Humans; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Topoisomerase II Inhibitors; Triterpenes | 2005 |
Triterpenoids from Eugenia grandis: structure elucidation by NMR spectroscopy.
Topics: Betulinic Acid; Deuterium; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Pentacyclic Triterpenes; Protons; Reference Standards; Sensitivity and Specificity; Sitosterols; Stereoisomerism; Syzygium; Triterpenes | 2007 |
Biotransformation of betulinic and betulonic acids by fungi.
Topics: Ascomycota; Betulinic Acid; Biotransformation; Colletotrichum; Fungi; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes | 2007 |
Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L.
Topics: Betulinic Acid; Chromatography, Gel; Hydrogen-Ion Concentration; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Solubility; Solutions; Triterpenes; Viscum album; Water | 2007 |
Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa.
Topics: 1-Butanol; Acetates; Animals; Antidiarrheals; Bacterial Toxins; Betulinic Acid; Diarrhea; Dose-Response Relationship, Drug; Enterotoxins; Enzyme-Linked Immunosorbent Assay; Escherichia coli Proteins; Female; Fruit; Immunoglobulin M; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Protein Binding; Protein Subunits; Rosaceae; Triterpenes; Ursolic Acid | 2007 |
Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae).
Topics: Anti-Infective Agents; Betulinic Acid; Cameroon; Candida; Cellulose; Diterpenes; Ellagic Acid; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Plant Extracts; Triterpenes | 2007 |
Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids.
Topics: Acetylation; Antitubercular Agents; Betulinic Acid; Cinnamates; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methylation; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oleanolic Acid; Pentacyclic Triterpenes; Spectrometry, Mass, Fast Atom Bombardment; Spectroscopy, Fourier Transform Infrared; Triterpenes; Ursolic Acid | 2008 |
Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid.
Topics: Betulinic Acid; Molecular Conformation; Oleanolic Acid; Pentacyclic Triterpenes; Stereoisomerism; Triterpenes; Ursolic Acid | 2008 |
Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes.
Topics: Anti-Bacterial Agents; Betulinic Acid; Cell Line; Cell Survival; Drug Resistance, Bacterial; Eukaryotic Cells; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Toxicity Tests; Triterpenes; Ursolic Acid | 2008 |
[Studies on chemical constituents from roots of Pterospermum heterophyllum].
Topics: Betulinic Acid; Chromatography; Malvaceae; Naphthoquinones; Oleanolic Acid; Palmitic Acid; Pentacyclic Triterpenes; Plant Roots; Sitosterols; Triterpenes | 2008 |
Identification and isolation of pharmacologically active triterpenes in Betuale cortex, Betula pendula Roth., Betulaceae.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Betula; Betulinic Acid; Chromatography, Thin Layer; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Spectrophotometry, Infrared; Triterpenes | 2009 |
Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
Topics: Betulinic Acid; Chromatography, Gas; Chromatography, High Pressure Liquid; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Triterpenes; Ursolic Acid | 2009 |
Chemical composition of the stem bark and leaves of Ficus pandurata Hance.
Topics: Betulinic Acid; Ficus; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Plant Leaves; Sitosterols; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stigmasterol; Triterpenes; Ursolic Acid | 2009 |
Anti-leishmanial activity of betulin derivatives.
Topics: Animals; Antiprotozoal Agents; Betulinic Acid; Cell Line; Cell Survival; Humans; Leishmania donovani; Macrophages; Mice; Oleanolic Acid; Oxidation-Reduction; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes | 2010 |
Triterpenoids from the roots of Pterospermum heterophyllum Hance.
Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Humans; Malvaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Palmitic Acid; Pentacyclic Triterpenes; Plant Roots; Sitosterols; Stereoisomerism; Terpenes; Triterpenes | 2009 |
[Studies on the chemical constituents from the seed of Forsythia suspense].
Topics: Betulinic Acid; Forsythia; Hydroxybenzoates; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Seeds; Triterpenes | 2009 |
Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.
Topics: Anti-HIV Agents; Betulinic Acid; Cell Line; Drug Design; HIV-1; Mutation; Oleanolic Acid; Pentacyclic Triterpenes; Stereoisomerism; Structure-Activity Relationship; Triterpenes; Virion; Virus Replication | 2010 |
Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.).
Topics: Betulinic Acid; Cell Line; Cell Survival; Humans; Immunologic Factors; Interleukin-6; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Rosa; Triterpenes; Ursolic Acid | 2011 |
[Studies on the triterpenoids of Vitex trifolia].
Topics: Betulinic Acid; Ethanol; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Triterpenes; Ursolic Acid; Vitex | 2010 |
Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits.
Topics: Betulinic Acid; Chromatography, High Pressure Liquid; Fluorescent Dyes; Food Analysis; Fruit; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid | 2011 |
Constituents of the root of Anemone tomentosa.
Topics: Anemone; Betulinic Acid; Coumarins; Drugs, Chinese Herbal; Free Radical Scavengers; Glycosides; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Phytosterols; Phytotherapy; Plant Roots; Saponins; Sterols; Structure-Activity Relationship; Triterpenes | 2011 |
CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis.
Topics: Amino Acid Sequence; Betulinic Acid; Biosynthetic Pathways; Cloning, Molecular; Cytochrome P-450 Enzyme System; Intramolecular Transferases; Medicago truncatula; Multienzyme Complexes; Oleanolic Acid; Pentacyclic Triterpenes; Phylogeny; Saccharomyces cerevisiae; Triterpenes; Ursolic Acid; Vitis | 2011 |
Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⁺ T-cell proliferation in human mononuclear cell cultures.
Topics: Acids; Autoantigens; B-Lymphocytes; Betulinic Acid; CD4-Positive T-Lymphocytes; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Immunologic; Flow Cytometry; Humans; Immunologic Factors; Inhibitory Concentration 50; Interleukin-10; Lipopolysaccharides; Oleanolic Acid; Pentacyclic Triterpenes; Plant Preparations; Rosa; Thyroglobulin; Triterpenes; Tumor Necrosis Factor-alpha; Ursolic Acid | 2012 |
Triterpenes from Callicarpa integerrima Champ.
Topics: Betulinic Acid; Callicarpa; Molecular Conformation; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Plant Stems; Plants, Medicinal; Saponins; Triterpenes; Ursolic Acid | 2012 |
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid.
Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes | 2012 |
Bioactive oleanane, lupane and ursane triterpene acid derivatives.
Topics: Animals; Artemia; Betulinic Acid; Esters; Free Radical Scavengers; Lamiaceae; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Triterpenes; Ursolic Acid | 2012 |
A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients.
Topics: Betulinic Acid; Dietary Supplements; Gas Chromatography-Mass Spectrometry; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Plants; Triterpenes; Ursolic Acid | 2013 |
Transcriptional profiles of the response of methicillin-resistant Staphylococcus aureus to pentacyclic triterpenoids.
Topics: Anti-Bacterial Agents; Betulinic Acid; Drug Resistance, Microbial; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Humans; Methicillin-Resistant Staphylococcus aureus; Oleanolic Acid; Pentacyclic Triterpenes; Staphylococcal Infections; Triterpenes | 2013 |
Potential targets by pentacyclic triterpenoids from Callicarpa farinosa against methicillin-resistant and sensitive Staphylococcus aureus.
Topics: Anti-Infective Agents; Betulinic Acid; Callicarpa; Gene Expression Regulation, Bacterial; Magnetic Resonance Spectroscopy; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Staphylococcal Infections; Staphylococcus aureus; Transcriptome; Triterpenes | 2014 |
Ethnopharmacology of Souroubea sympetala and Souroubea gilgii (Marcgraviaceae) and identification of betulinic acid as an anxiolytic principle.
Topics: Animals; Anti-Anxiety Agents; Betulinic Acid; Costa Rica; Diazepam; Dose-Response Relationship, Drug; Ethnopharmacology; Fruit; Magnoliopsida; Male; Medicine, Traditional; Oleanolic Acid; Pentacyclic Triterpenes; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Plant Stems; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Triterpenes | 2015 |
Chemical constituents of gold-red apple and their α-glucosidase inhibitory activities.
Topics: alpha-Glucosidases; alpha-Linolenic Acid; Betulinic Acid; Fruit; Glycoside Hydrolase Inhibitors; Magnetic Resonance Spectroscopy; Malus; Oleanolic Acid; Pentacyclic Triterpenes; Spectrometry, Mass, Electrospray Ionization; Triterpenes; Ursolic Acid | 2014 |
[Study on chemical constituents from crop pathogenic fungus active fraction of Wisteria sinensis tumor].
Topics: Betulinic Acid; Flavonoids; Fungi; Furans; Lignans; Oleanolic Acid; Pentacyclic Triterpenes; Plant Diseases; Triterpenes; Wisteria | 2014 |
Simultaneous determination of six triterpenic acids in some Chinese medicinal herbs using ultrasound-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography with fluorescence detection.
Topics: Betulinic Acid; Chromatography, High Pressure Liquid; Fluorescence; Limit of Detection; Liquid Phase Microextraction; Medicine, Chinese Traditional; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Solvents; Triterpenes; Ultrasonics; Ursolic Acid | 2015 |
Quantitative determination of three pentacyclic triterpenes from five Swertia L. species endemic to Western Ghats, India, using RP-HPLC analysis.
Topics: Betulinic Acid; Chromatography, High Pressure Liquid; India; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Species Specificity; Swertia; Triterpenes; Ursolic Acid | 2015 |
[Chemical constituents of Clerodendrum trichotomum Leaves].
Topics: Betulinic Acid; Clerodendrum; Indoles; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Sitosterols; Sterols; Stigmasterol; Triterpenes | 2014 |
[Study on Chemical Composition of Phyllanthus emblica].
Topics: Betulinic Acid; Gallic Acid; Oleanolic Acid; Pentacyclic Triterpenes; Phyllanthus emblica; Phytochemicals; Plants, Medicinal; Quercetin; Rutin; Triterpenes; Ursolic Acid | 2015 |
Betulinic acid and oleanolic acid, natural pentacyclic triterpenoids, interfere with N-linked glycan modifications to intercellular adhesion molecule-1, but not its intracellular transport to the cell surface.
Topics: alpha-Mannosidase; Betulinic Acid; Cell Line, Tumor; Glycoside Hydrolase Inhibitors; Humans; Indolizines; Intercellular Adhesion Molecule-1; Interleukin-1alpha; Oleanolic Acid; Pentacyclic Triterpenes; Protein Transport; Swainsonine; Triterpenes | 2015 |
[Chemical Components from Leaves of Fatsia japonica and Their Antitumor Activities in vitro].
Topics: Antineoplastic Agents, Phytogenic; Araliaceae; Betulinic Acid; Cell Line, Tumor; Chromatography, High Pressure Liquid; Flavones; Furans; Glucosides; Humans; Kaempferols; Lactones; Lignans; Oleanolic Acid; Pentacyclic Triterpenes; Phytochemicals; Plant Leaves; Sitosterols; Triterpenes | 2015 |
Comparison of the inhibition capability of oleanolic acid and betulinic acid towards drug-metabolizing enzymes.
Topics: Betulinic Acid; Drug Interactions; Glucuronosyltransferase; Humans; Hymecromone; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes | 2015 |
Determination of betulinic acid, oleanolic acid and ursolic acid from Achyranthes aspera L. using RP-UFLC-DAD analysis and evaluation of various parameters for their optimum yield.
Topics: Achyranthes; Betulinic Acid; Chromatography, Reverse-Phase; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid | 2016 |
[Chemical Constituents from Camellia oleifera Stem].
Topics: Betulinic Acid; Camellia; Drugs, Chinese Herbal; Flavonoids; Furans; Lignans; Oleanolic Acid; Pentacyclic Triterpenes; Phytochemicals; Plant Stems; Plants, Medicinal; Triterpenes; Ursolic Acid | 2015 |
Synthesis of novel lupane triterpenoid-indazolone hybrids with oxime ester linkage.
Topics: Betulinic Acid; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes | 2017 |
Evaluation of seasonal changes of triterpenic acid contents in Viscum album from different host trees.
Topics: Acetates; Betulinic Acid; Chromatography, High Pressure Liquid; Oleanolic Acid; Pentacyclic Triterpenes; Reproducibility of Results; Seasons; Solvents; Spectrometry, Mass, Electrospray Ionization; Time Factors; Trees; Triterpenes; Ultrasonics; Viscum album | 2017 |
Biological evaluation of a halogenated triterpenoid, 2α-bromo-dihydrobelulonic acid as inhibitor of human topoisomerase IIα and HeLa cell proliferation.
Topics: Antigens, Neoplasm; Apoptosis; Betulinic Acid; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; G1 Phase Cell Cycle Checkpoints; Halogenation; HeLa Cells; Humans; Intercalating Agents; Oleanolic Acid; Pentacyclic Triterpenes; Proliferating Cell Nuclear Antigen; Spectrometry, Fluorescence; Streptophyta; Topoisomerase II Inhibitors; Triterpenes | 2017 |
Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in Ewing sarcoma cells reveals cellular stress responses.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Betulinic Acid; Cell Proliferation; Humans; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oleanolic Acid; Oxidative Stress; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Plant Lectins; Plant Proteins; Proteasome Endopeptidase Complex; Proteome; Proteomics; Sarcoma, Ewing; Signal Transduction; Transcriptome; Triterpenes; Tumor Cells, Cultured; Viscum album | 2017 |
Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae).
Topics: Antitubercular Agents; Apocynaceae; Betulinic Acid; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Mycobacterium tuberculosis; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Plant Leaves; Rauwolfia; Sitosterols; Triterpenes | 2018 |
Antimicrobial Mechanism of Oleanolic and Ursolic Acids on Streptococcus mutans UA159.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Betulinic Acid; Gene Expression Regulation, Bacterial; Oleanolic Acid; Pentacyclic Triterpenes; Streptococcus mutans; Triterpenes; Ursolic Acid | 2018 |
Betulinic, oleanolic and ursolic acids inhibit the enzymatic and biological effects induced by a P-I snake venom metalloproteinase.
Topics: Animals; Betulinic Acid; Bothrops; Crotalid Venoms; Edema; Hemorrhage; Metalloproteases; Mice; Molecular Structure; Muscular Diseases; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid | 2018 |
Study of isomeric pentacyclic triterpene acids in traditional Chinese medicine of Forsythiae Fructus and their binding constants with β-cyclodextrin by capillary electrophoresis.
Topics: beta-Cyclodextrins; Betulinic Acid; Drugs, Chinese Herbal; Electrophoresis, Capillary; Forsythia; Fruit; Isomerism; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Thermodynamics; Triterpenes; Ursolic Acid | 2018 |
Combination of phase-solubility method and capillary zone electrophoresis to determine binding constants of cyclodextrins with practically water-insoluble compounds.
Topics: Betulinic Acid; Cyclodextrins; Electrolytes; Electrophoresis, Capillary; Oleanolic Acid; Pentacyclic Triterpenes; Solubility; Temperature; Triterpenes; Water | 2018 |
Quantification of three triterpenic acids in dried rosemary using HPLC-fluorescence detection and 4-(4,5-diphenyl-1H-imidazole-2-yl)benzoyl chloride derivatization.
Topics: Benzoates; Betulinic Acid; Calibration; Chromatography, High Pressure Liquid; Fluorescence; Food Analysis; Imidazoles; Limit of Detection; Oleanolic Acid; Pentacyclic Triterpenes; Reproducibility of Results; Rosmarinus; Temperature; Triterpenes; Ursolic Acid | 2019 |
NMR-based systematic analysis of bioactive phytochemicals in red wine. First determination of xanthurenic and oleanic acids.
Topics: Betulinic Acid; Magnetic Resonance Spectroscopy; Oleanolic Acid; Pentacyclic Triterpenes; Phytochemicals; Triterpenes; Vitis; Wine; Xanthurenates | 2019 |
A new pentacyclic triterpenoid from the leaves of
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betulinic Acid; Drug Evaluation, Preclinical; Lipopolysaccharides; Mice; Molecular Structure; Nitric Oxide; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Plant Leaves; RAW 264.7 Cells; Rhododendron; Triterpenes; Ursolic Acid | 2020 |
Synthesis, Anticancer, and Antibacterial Activity of Betulinic and Betulonic Acid C-28-Triphenylphosphonium Conjugates with Variable Alkyl Linker Length.
Topics: Alkanes; Anti-Bacterial Agents; Antineoplastic Agents; Antioxidants; Apoptosis; Betulinic Acid; Cytosol; Drug Design; Esters; Fluoresceins; Fluorescent Dyes; Gram-Positive Bacteria; Halogens; Humans; Mitochondria; Molecular Structure; Oleanolic Acid; Organophosphorus Compounds; PC-3 Cells; Pentacyclic Triterpenes; Structure-Activity Relationship; Superoxides; Triterpenes | 2020 |
Antimicrobial properties of amine- and guanidine-functionalized derivatives of betulinic, ursolic and oleanolic acids: Synthesis and structure/activity evaluation.
Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Antifungal Agents; Betulinic Acid; Candida albicans; Cell Survival; Cryptococcus neoformans; Dose-Response Relationship, Drug; Escherichia coli; HEK293 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Pseudomonas aeruginosa; Structure-Activity Relationship; Triterpenes; Ursolic Acid | 2020 |
Expression characteristics and function of CAS and a new beta-amyrin synthase in triterpenoid synthesis in birch (Betula platyphylla Suk.).
Topics: Abscisic Acid; Acetates; Betula; Betulinic Acid; Cyclopentanes; Gene Expression Regulation, Plant; Gibberellins; Intramolecular Transferases; Oleanolic Acid; Oxylipins; Pentacyclic Triterpenes; Squalene; Triterpenes | 2020 |
Functional identification of BpMYB21 and BpMYB61 transcription factors responding to MeJA and SA in birch triterpenoid synthesis.
Topics: Acetates; Betula; Betulinic Acid; Conserved Sequence; Cyclopentanes; Gene Expression Profiling; Gene Expression Regulation, Plant; Oleanolic Acid; Oxylipins; Pentacyclic Triterpenes; Plants, Genetically Modified; Promoter Regions, Genetic; Protein Domains; Salicylates; Squalene; Transcription Factors; Triterpenes | 2020 |