oleanolic acid has been researched along with beta-hederin in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.33) | 18.7374 |
| 1990's | 16 (21.33) | 18.2507 |
| 2000's | 21 (28.00) | 29.6817 |
| 2010's | 33 (44.00) | 24.3611 |
| 2020's | 4 (5.33) | 2.80 |
| Authors | Studies |
|---|---|
| Asano, T; Kuroda, M; Mimaki, Y; Sashida, Y | 1 |
| Gauthier, C; Girard-Lalancette, K; Legault, J; Mshvildadze, V; Pichette, A | 1 |
| Sha, ZF; Sun, WJ; Zhang, DK; Zhang, HL; Zhang, XL | 1 |
| Jia, XS; Mao, Q | 1 |
| Bullock, P; Klaassen, CD; Liu, J; Liu, Y | 1 |
| Angenot, L; Balansard, G; Bassleer, R; Coucke, P; Danloy, S; De Pauw-Gillet, MC; Elias, R; Quetin-Leclercq, J | 1 |
| Andrews, GK; Choudhuri, S; Klaassen, CD; Kreppel, H; Liu, J; Liu, Y | 1 |
| Iszard, MB; Klaassen, CD; Liu, J | 1 |
| Amara-Mokrane, YA; Balansard, G; Botta, A; Duménil, G; Lehucher-Michel, MP | 1 |
| Baines, D; Daston, GP; Duffy, JY; Keen, CL; Overmann, GJ | 1 |
| Jeong, HG; Park, HY | 1 |
| Liu, GT; Shi, JZ | 1 |
| Jeong, HG | 1 |
| Bang, KH; Kim, DW; Lee, KT; Park, HJ; Rhee, YH | 1 |
| Elias, R; Favel, A; Moulin-Traffort, J; Regli, P | 1 |
| Liu, J; Liu, YP | 1 |
| Jeong, HG; Lee, SS | 1 |
| De Méo, M; Duménil, G; Elias, R; Guiraud-Dauriac, H; Laget, M; Mba Gachou, C | 1 |
| Azas, N; Dekanosidze, G; Delmas, F; Di Giorgio, C; Elias, R; Gasquet, M; Kemertelidze, E; Mshvildadze, V; Timon-David, P | 1 |
| Huat, BT; Kumara, SS | 1 |
| Kwon, SH; Lee, JH; Lee, KH; Lee, KT; Miyamoto, K; Park, HJ | 1 |
| Choi, J; Huh, K; Kim, SH; Kwon, SH; Lee, KT; Park, HJ | 1 |
| Balansard, G; Dekanosidze, G; Delmas, F; Di Giorgio, C; Elias, R; Kemertelidze, E; Mshvildadze, V; Ridoux, O; Timon-David, P | 1 |
| Choi, J; Huh, K; Kim, SH; Lee, HK; Lee, KT; Park, HJ | 1 |
| Choi, J; Han, YN; Huh, K; Kim, SH; Lee, KT; Park, HJ | 1 |
| Choi, CY; Jeong, HG | 1 |
| Hyun, JE; Jeong, CS; Kim, YS; Lee, EB; Li, DW | 1 |
| Huat, BT; Swamy, SM | 1 |
| Baader, SL; Häberlein, H; Hegener, O; Kappler, J; Prenner, L; Runkel, F | 1 |
| Elias, R; Gepdiremen, A; Gülçin, I; Mshvildadze, V | 1 |
| Elias, R; Gepdiremen, A; Mshvildadze, V; Süleyman, H | 1 |
| Choi, CY; Jeong, HG; Kim, JY | 1 |
| Liu, QH; Liu, YM; Yang, JS | 1 |
| Cheng, MS; Liu, J; Liu, Y; Yan, MC; Zheng, LG | 1 |
| Bang, SC; Hoang, le TA; Jung, SH; Lee, KC; Seo, HH; Shin, HR | 1 |
| Baghdikian, B; Balansard, G; Bun, SS; Ciccolini, J; Elias, R; Ollivier, E | 1 |
| Häberlein, H; Jakobs, D; Prenner, L; Runkel, F; Sieben, A; Sorkalla, T; Wolf, A | 1 |
| Fischer, R; Harig, L; Leupold, M; Lipinski, M; Luftmann, H; Müller, KJ; Ofir, R; Prüfer, D; Scholz, M | 1 |
| Nagao, T; Nielsen, JK; Okabe, H; Shinoda, T | 1 |
| Apers, S; Cuyckens, F; Foubert, K; Pieters, L; Theunis, M; Vleeschouwer, K; Vlietinck, A | 1 |
| Chalifa-Caspi, V; Feller, G; Kugel, A; Moonshine, D; Müller, KJ; Ofir, R; Prüfer, D; Rabinski, T; Scholz, M | 1 |
| Gosens, R; Häberlein, H; Meurs, H; Wolf, A | 1 |
| Cheng, MS; Ikejima, T; Liu, Y; Lu, WX; Yan, MC; Yu, Y | 1 |
| Chłopecka, M; Dziekan, N; Karlik, W; Mendel, M; Wiechetek, M | 2 |
| Cheng, MS; Chun, J; Han, L; Joo, EJ; Kim, YS; Liu, Y; Wang, B; Wang, YS | 1 |
| Le Duff, CS; Lorent, J; Mingeot-Leclercq, MP; Quetin-Leclercq, J | 1 |
| Prescott, TA; Rigby, LP; Simmonds, MS; Veitch, NC | 1 |
| Brasseur, R; Domenech, Ò; Lins, L; Lorent, J; Mingeot-Leclercq, MP; Quetin-Leclercq, J | 1 |
| Cheng, L; Ding, Q; Liang, XQ; Shi, L; Wang, M; Wang, Y; Wang, YF; Xia, TS; Xue, JQ; Zhou, W | 1 |
| Greunke, C; Häberlein, F; Häberlein, H; Hage-Hülsmann, A; Keksel, N; Sorkalla, T | 1 |
| Aslani, MR; Fallahi, M; Keyhanmanesh, R; Mohammadi, M; Saadat, S | 1 |
| Fallahi, M; Keyhanmanesh, R; Mohammadi, M; Saadat, S; Shahbazfar, AA | 1 |
| Havliková, L; Macáková, K; Opleta, L; Solich, P | 1 |
| Chen, WL; Li, JZ; Liu, Y; Yang, SD; You, BG; Yuan, ZQ; Zhang, CG; Zhang, XN; Zhou, XF; Zhu, R; Zhu, WJ | 1 |
| Geue, T; Gutberlet, T; Orczyk, M; Wojciechowski, K | 1 |
| Ebrahimi Saadatlou, MA; Ebrahimi, H; Fallahi, M; Keyhanmanesh, R; Khamaneh, AM; Saadat, S | 1 |
| Aatz, S; Engelhard, K; Häberlein, F; Häberlein, H; Martinez-Osuna, M; Schulte-Michels, J; Sieben, A; Wolf, A | 1 |
| Li, L; Liu, J; Xing, Y; Xu, H; Yu, M; Yu, Z; Zhao, Y | 1 |
| Abouzi, M; Akabi, F; Léonard, C; Lorent, JH; Mingeot-Leclercq, MP; Quetin-Leclercq, J | 1 |
| Law, BY; Liu, L; Lo, AC; Wong, VK; Wu, AG; Zeng, W; Zhu, YZ | 1 |
| Feng, YL; He, MZ; Li, Y; Li, ZF; Liu, Z; Ouyang, H; Yang, SL | 1 |
| Cheng, H; Fan, H; Li, L; Miao, Y; Shen, W; Sun, D; Tan, J; Xu, C; Yang, Y; Zhang, F; Zhang, H | 1 |
| Ahmad, A; Ahmad, IZ; Tabassum, H | 1 |
| Chen, B; Du, B; Gong, Q; Ho, HI; Li, Q; Liu, X; Lu, Y; Tan, Y; Wang, K; Wu, W; Xiao, J; Yin, T; Zhan, Y; Zhang, F; Zhang, Y; Zou, Y | 1 |
| Choi, SJ; Jeon, TJ; Jeong, KB; Kim, KB; Kim, YR; Lee, H; Lim, MC; Luo, K; Yu, J | 1 |
| Cai, G; Feng, Y; Huang, Y; Ji, Q; Li, Q; Shi, L; Sun, J; Wang, Y; Zhang, J | 1 |
| Gao, W; Li, P; Li, XS; Liu, K; Liu, XG; Wang, R; Yang, H | 1 |
| Dong, W; Liu, H; Wang, J; Wu, D; Wu, J; Zhang, J | 1 |
| Adamska, A; Ochocka, JR; Stefanowicz-Hajduk, J | 1 |
| Deng, H; Dong, W; He, P; Liu, Y; Ma, J | 1 |
| Deng, H; Dong, W; Li, J; Ma, J; Wang, J; Wu, D; Zhang, J | 1 |
| Chu, DT; Ferdous, J; Hannan, MA; Hossain, KS; Islam, MN; Rahman, MM; Sarker, PP; Uddin, MJ | 1 |
| Hwang, IS; Jeong, KB; Kim, YR; Lee, H; Luo, K; Park, JS; You, SM | 1 |
| Aslani, MR; Boskabady, MH; Ghorani, V; Keyhanmanesh, R; Saadat, S | 1 |
3 review(s) available for oleanolic acid and beta-hederin
| Article | Year |
|---|---|
Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review.
Topics: Animals; Antioxidants; Benzoquinones; Humans; Lipid Peroxidation; Liver Diseases; Nigella sativa; Oleanolic Acid; Plant Extracts; Protective Agents; Reactive Oxygen Species; Saponins; Superoxide Dismutase | 2018 |
Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure.
Topics: Benzoquinones; COVID-19 Drug Treatment; Diabetes Mellitus; Dietary Supplements; Humans; Nigella sativa; Oleanolic Acid; Pandemics; Plant Extracts; Saponins; Seeds | 2021 |
The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Cymenes; Humans; Hypersensitivity; Immune System Diseases; Immunologic Factors; Nigella sativa; Oleanolic Acid; Phytotherapy; Plant Extracts; Respiratory Tract Diseases; Saponins; Thymol | 2021 |
72 other study(ies) available for oleanolic acid and beta-hederin
| Article | Year |
|---|---|
Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells.
Topics: Antineoplastic Agents, Phytogenic; Carbohydrate Conformation; Carbohydrate Sequence; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Lignans; Medicine, Chinese Traditional; Molecular Sequence Data; Plant Roots; Plants, Medicinal; Saponins; Spectrum Analysis; Triterpenes | 1999 |
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
Topics: Animals; Cell Line, Tumor; Cell Membrane Permeability; Erythrocytes; Hemolysis; Humans; Oleanolic Acid; Saponins; Sheep; Triterpenes | 2009 |
[Studies on the saponin constituents of Kalopanax septemlobus (Thunb.) koidz].
Topics: Chemical Phenomena; Chemistry; Drugs, Chinese Herbal; Oleanolic Acid; Saponins | 1990 |
[Studies on the chemical constituents of Lonicera fulvotomentosa Hsu et S.C. Cheng].
Topics: Chemical Phenomena; Chemistry; Drugs, Chinese Herbal; Oleanolic Acid; Saponins | 1989 |
Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Antagonism; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Liver Diseases; Male; Methylation; Mice; Microsomes, Liver; Oleanolic Acid; Saponins | 1995 |
Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro.
Topics: 3T3 Cells; Animals; Antineoplastic Agents, Phytogenic; Carbohydrate Sequence; Mice; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Tumor Cells, Cultured | 1994 |
Induction of metallothionein by alpha-hederin.
Topics: Alanine Transaminase; Animals; Binding Sites; Blotting, Northern; Cadmium; Cadmium Chloride; Chlorides; Cytosol; Dose-Response Relationship, Drug; L-Iditol 2-Dehydrogenase; Liver; Male; Metallothionein; Mice; Microsomes, Liver; Mitochondria, Liver; Oleanolic Acid; RNA, Messenger; Saponins; Tissue Distribution | 1993 |
Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats.
Topics: Analysis of Variance; Animals; Cadmium; Cadmium Chloride; Carcinogens; Catalase; Chlorides; Cytochrome P-450 Enzyme System; Cytochromes b5; Cytosol; Dihydrolipoamide Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Lipopolysaccharides; Liver; Male; Metallothionein; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Selenium; Superoxide Dismutase; Testosterone; Zinc Compounds | 1995 |
Protective effects of alpha-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes.
Topics: Adult; Antimutagenic Agents; Ascorbic Acid; Cells, Cultured; Chlorophyllides; Doxorubicin; Humans; Lymphocytes; Micronucleus Tests; Oleanolic Acid; Saponins; Time Factors | 1996 |
Repeated administration of alpha-hederin results in alterations in maternal zinc status and adverse developmental outcome in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Embryonic and Fetal Development; Female; Maternal-Fetal Exchange; Metallothionein; Oleanolic Acid; Pregnancy; Pregnancy Outcome; Rats; Rats, Sprague-Dawley; Saponins; Zinc; Zinc Radioisotopes | 1997 |
The prevention of carbon tetrachloride-induced hepatotoxicity in mice by alpha-hederin: inhibiton of cytochrome P450 2E1 expression.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drugs, Chinese Herbal; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oleanolic Acid; Saponins | 1998 |
Effect of alpha-hederin and sapindoside B on hepatic microsomal cytochrome P-450 in mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Male; Mice; Microsomes, Liver; Oleanolic Acid; Phenobarbital; Saponins | 1996 |
Suppression of constitutive and inducible cytochrome P450 gene expression by alpha-hederin in mice.
Topics: Aniline Hydroxylase; Animals; Blotting, Northern; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gene Expression Regulation; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oleanolic Acid; Oxidoreductases; Phenobarbital; Protein Isoforms; Pyridines; Saponins; Time Factors | 1998 |
Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi.
Topics: Antifungal Agents; Arthrodermataceae; Candida albicans; Cryptococcus neoformans; Fungi; Humans; Microbial Sensitivity Tests; Oleanolic Acid; Saponins | 1998 |
Study of the action of alpha-hederin on the ultrastructure of Candida albicans.
Topics: Antifungal Agents; Candida albicans; Microscopy, Electron; Oleanolic Acid; Saponins | 1998 |
Effect of alpha-hederin on hepatic detoxifying systems in mice.
Topics: Animals; Antioxidants; Catalase; Copper; Drugs, Chinese Herbal; Glutathione; Liver; Male; Metallothionein; Mice; Oleanolic Acid; Saponins; Zinc | 1997 |
Suppressive effects of alpha-Hederin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated murine Cyp1a-1 expression in the mouse hepatoma Hepa-1c1c7 cells.
Topics: Animals; Cytochrome P-450 CYP1A1; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Liver Neoplasms, Experimental; Mice; Oleanolic Acid; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Saponins; Tumor Cells, Cultured | 1999 |
The protective activity of alpha-hederine against H2O2 genotoxicity in HepG2 cells by alkaline comet assay.
Topics: Catalase; Cell Membrane; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Glutathione; Humans; Hydrogen Peroxide; Mutagenicity Tests; Oleanolic Acid; Oxidation-Reduction; Protective Agents; Proteins; Saponins; Tumor Cells, Cultured | 1999 |
Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro.
Topics: Animals; Antiprotozoal Agents; Cell Division; Cell Line; Humans; Leishmania infantum; Oleanolic Acid; Saponins | 2000 |
Extraction, isolation and characterisation of antitumor principle, alpha-hederin, from the seeds of Nigella sativa.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Drug Screening Assays, Antitumor; Magnoliopsida; Mice; Molecular Structure; Oleanolic Acid; Saponins; Seeds; Tumor Cells, Cultured | 2001 |
Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Glycosides; Humans; Male; Mice; Mice, Inbred Strains; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Toxicology of Kalopanax pictus extract and hematological effect of the isolated anti-rheumatoidal kalopanaxsaponin A on the Freunds complete adjuvant reagent-treated rat.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Blood Cell Count; Body Weight; Cholesterol; Drugs, Chinese Herbal; Freund's Adjuvant; Indicators and Reagents; L-Lactate Dehydrogenase; Lethal Dose 50; Liver Function Tests; Mice; Mice, Inbred ICR; Oleanolic Acid; Organ Size; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Saponins; Triglycerides | 2001 |
In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B.
Topics: Animals; Antiprotozoal Agents; Leishmania mexicana; Magnoliopsida; Oleanolic Acid; Parasitic Sensitivity Tests; Plants, Medicinal; Saponins | 2001 |
Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Antioxidants; Arthritis, Rheumatoid; Cytochrome P-450 Enzyme System; Freund's Adjuvant; Liver; Male; Oleanolic Acid; Oxidoreductases; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins | 2002 |
Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals.
Topics: Analgesics; Animals; Antirheumatic Agents; Araliaceae; Arthritis, Experimental; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Pain Measurement; Phytotherapy; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins | 2002 |
Expression of inducible nitric oxide synthase by alpha-hederin in macrophages.
Topics: Animals; Caprifoliaceae; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Female; Gene Expression Regulation, Enzymologic; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oleanolic Acid; Polymyxin B; RNA, Messenger; Saponins | 2002 |
Antiinflammatory activity of alpha-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Butanols; Edema; Esters; Hydrolysis; Kalopanax; Male; Oleanolic Acid; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins | 2003 |
Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells.
Topics: Animals; Apoptosis; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; Intracellular Membranes; Leukemia P388; Mice; Mitochondria; Nigella sativa; Oleanolic Acid; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Saponins; Tumor Cells, Cultured | 2003 |
Dynamics of beta2-adrenergic receptor-ligand complexes on living cells.
Topics: Adrenergic beta-Agonists; Animals; Cell Line; Colforsin; Endocytosis; Epithelial Cells; Fluorescent Dyes; Hippocampus; Humans; Immunohistochemistry; Ligands; Molecular Structure; Neurons; Norepinephrine; Oleanolic Acid; Protein Isoforms; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Saponins; Spectrometry, Fluorescence; Terbutaline | 2004 |
Antioxidant activity of saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F.
Topics: Antioxidants; Biphenyl Compounds; Hedera; Humans; Lipid Peroxidation; Oleanolic Acid; Phytotherapy; Picrates; Plant Extracts; Saponins | 2004 |
Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Edema; Hedera; Male; Oleanolic Acid; Phytotherapy; Plant Leaves; Rats; Rats, Wistar; Saponins; Structure-Activity Relationship | 2005 |
Involvement of cytokines in the hepatic metallothionein expression by alpha-hederin.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Interleukin-6; Macrophages; Metallothionein; Mice; Oleanolic Acid; Phytotherapy; Plants, Medicinal; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Tumor Necrosis Factor-alpha | 2005 |
[Studies on chemical constituents in the seeds of Nigella glandulifera].
Topics: Glycosides; Molecular Conformation; Molecular Structure; Nigella; Oleanolic Acid; Plants, Medicinal; Saponins; Seeds; Sitosterols | 2005 |
Synthesis of beta-hederin and Hederacolchiside A1: triterpenoid saponins bearing a unique cytotoxicity-inducing disaccharide moiety.
Topics: Antineoplastic Agents; Arabinose; Carbohydrate Sequence; Disaccharides; Oleanolic Acid; Rhamnose; Saponins | 2006 |
A convenient preparation of a disaccharide motif and its role in the cytotoxicity of the triterpenoid saponin, alpha-hederin.
Topics: Anisoles; Antineoplastic Agents; Cell Line, Tumor; Disaccharides; Drug Screening Assays, Antitumor; Humans; Oleanolic Acid; Saponins; Triterpenes | 2008 |
Alpha-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Fluorouracil; HT29 Cells; Humans; Oleanolic Acid; Saponins | 2008 |
Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.
Topics: Cell Line; Cell Line, Tumor; Endocytosis; Hedera; Humans; Oleanolic Acid; Protein Binding; Receptors, Adrenergic, beta-2; Saponins; Thermodynamics | 2009 |
Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa.
Topics: Acetates; Chromatography, High Pressure Liquid; Cyclopentanes; Intramolecular Transferases; Nigella sativa; Oleanolic Acid; Oxylipins; Plant Growth Regulators; Plant Proteins; Saponins; Transcription, Genetic; Yeasts | 2009 |
Resistance in the plant, Barbarea vulgaris, and counter-adaptations in flea beetles mediated by saponins.
Topics: Alleles; Animals; Barbarea; Coleoptera; Female; Genotype; Male; Oleanolic Acid; Sapogenins; Saponins | 2010 |
Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS.
Topics: Animals; Calibration; Chemistry Techniques, Analytical; Chromatography; Ions; Mass Spectrometry; Models, Chemical; Mollusca; Oleanolic Acid; Primulaceae; Reproducibility of Results; Saponins; Sensitivity and Specificity; Sodium; Tandem Mass Spectrometry | 2010 |
African descents are more sensitive than European descents to the antitumor compounds α-hederin and kalopanaxsaponin I.
Topics: Animals; Antineoplastic Agents, Phytogenic; Black People; Cell Line, Tumor; Growth Inhibitors; Humans; Lymphocyte Activation; Mice; Neoplasms; Nigella; Oleanolic Acid; Pharmacogenetics; Phytotherapy; Plant Extracts; Polymorphism, Single Nucleotide; Saponins; Seeds; White People | 2010 |
Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle.
Topics: Adrenergic beta-Agonists; Animals; Bronchodilator Agents; Cattle; Drug Synergism; Hedera; Histamine; Isoproterenol; Methacholine Chloride; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oleanolic Acid; Plant Extracts; Plant Leaves; Saponins; Trachea | 2011 |
Synthesis and tumor cytotoxicity of novel amide derivatives of β-hederin.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship | 2010 |
Participation of cholinergic pathways in α-hederin-induced contraction of rat isolated stomach strips.
Topics: Acetylcholine; Animals; Araliaceae; Atropine; Cholinergic Agents; Hexamethonium; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Oleanolic Acid; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Reference Values; Saponins; Signal Transduction; Stomach | 2012 |
Synthesis of novel diosgenyl saponin analogues and apoptosis-inducing activity on A549 human lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Caspase 8; Caspase 9; Cell Line, Tumor; DNA Fragmentation; Glycosylation; Humans; Lung; Lung Neoplasms; Oleanolic Acid; Saponins | 2012 |
Participation of extracellular calcium in α-hederin-induced contractions of rat isolated stomach strips.
Topics: Animals; Calcium; Calcium Channel Blockers; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Oleanolic Acid; Rats; Rats, Wistar; Saponins; Stomach; Verapamil | 2013 |
Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin.
Topics: Cell Line, Tumor; Cell Membrane; Cell Membrane Permeability; Cholesterol; Humans; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membrane Potentials; Microscopy, Fluorescence; Models, Chemical; Monocytes; Oleanolic Acid; Saponins; Sterols; Temperature; Time Factors | 2013 |
The haploinsufficiency profile of α-hederin suggests a caspofungin-like antifungal mode of action.
Topics: Antifungal Agents; Caspofungin; Echinocandins; Gene Deletion; Haploinsufficiency; Hedera; Lipopeptides; Oleanolic Acid; Plant Extracts; Plant Leaves; Saccharomyces cerevisiae; Saponins | 2014 |
Domain formation and permeabilization induced by the saponin α-hederin and its aglycone hederagenin in a cholesterol-containing bilayer.
Topics: Cholesterol; Lipid Bilayers; Membrane Microdomains; Oleanolic Acid; Saponins | 2014 |
The anticancer effect and mechanism of α-hederin on breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Clematis; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Oleanolic Acid; Phytotherapy; Plant Extracts; Saponins | 2014 |
A systematic study on the influence of the main ingredients of an ivy leaves dry extract on the β2-adrenergic responsiveness of human airway smooth muscle cells.
Topics: Chromatography, High Pressure Liquid; Cyclic AMP; Dose-Response Relationship, Drug; Flavonoids; Hedera; HEK293 Cells; Humans; Hydroxybenzoates; Mass Spectrometry; Myocytes, Smooth Muscle; Oleanolic Acid; Plant Extracts; Plant Leaves; Receptors, Adrenergic, beta-2; Saponins | 2015 |
The protective effect of α-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Bronchodilator Agents; Guinea Pigs; Histamine; Male; Methacholine Chloride; Nigella sativa; Oleanolic Acid; Ovalbumin; Plants, Medicinal; Pneumonia; Saponins; Trachea | 2015 |
The Protective Effect of α-Hederin, the Active Constituent of Nigella sativa, on Lung Inflammation and Blood Cytokines in Ovalbumin Sensitized Guinea Pigs.
Topics: Animals; Benzoquinones; Cytokines; Drugs, Chinese Herbal; Fluticasone; Guinea Pigs; Interleukin-17; Interleukin-4; Lung; Male; Nigella sativa; Oleanolic Acid; Ovalbumin; Plant Extracts; Pneumonia; Saponins | 2015 |
Rapid Determination of α-Hederin and Hederacoside C in Extracts of Hedera helix Leaves Available in the Czech Republic and Poland.
Topics: Chromatography, High Pressure Liquid; Czech Republic; Hedera; Oleanolic Acid; Plant Extracts; Plant Leaves; Poland; Reproducibility of Results; Saponins | 2015 |
CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells.
Topics: Animals; Annexin A5; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Basigin; Chitosan; Endocytosis; Flow Cytometry; Fluorescence; Hep G2 Cells; Humans; Imaging, Three-Dimensional; Intracellular Space; Liver Neoplasms; Mice, Nude; Microscopy, Confocal; Nanoparticles; Oleanolic Acid; Particle Size; Propidium; Saponins; Spectroscopy, Fourier Transform Infrared; Spectroscopy, Near-Infrared; Subcellular Fractions | 2015 |
Complexation of phospholipids and cholesterol by triterpenic saponins in bulk and in monolayers.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Cholesterol; Glycyrrhetinic Acid; Membranes, Artificial; Oleanolic Acid; Saponins | 2016 |
Effect of α-Hederin on IL-2 and IL-17 mRNA and miRNA-133a Levels in Lungs of Ovalbumin-Sensitized Male Rats.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Interleukin-17; Interleukin-2; Lung; Male; MicroRNAs; Oleanolic Acid; Ovalbumin; Rats, Wistar; RNA, Messenger; Saponins | 2016 |
α-Hederin inhibits G protein-coupled receptor kinase 2-mediated phosphorylation of β2-adrenergic receptors.
Topics: Cyclic AMP-Dependent Protein Kinases; G-Protein-Coupled Receptor Kinase 2; Hedera; HEK293 Cells; Humans; Isoproterenol; Oleanolic Acid; Phosphorylation; Receptors, Adrenergic, beta-2; Recombinant Fusion Proteins; Saponins; Signal Transduction | 2016 |
Pharmacokinetic parameters of three active ingredients hederacoside C, hederacoside D, and ɑ-hederin in Hedera helix in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Hedera; Male; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry | 2016 |
α-Hederin Induces Apoptosis, Membrane Permeabilization and Morphologic Changes in Two Cancer Cell Lines Through a Cholesterol-Dependent Mechanism.
Topics: Apoptosis; Calcium; Cell Membrane Permeability; Cholesterol; Humans; Oleanolic Acid; Saponins; U937 Cells | 2016 |
Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenylate Kinase; alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Disease Models, Animal; Drugs, Chinese Herbal; Female; Hedera; Huntingtin Protein; Male; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Oleanolic Acid; PC12 Cells; Rats; Saponins; TOR Serine-Threonine Kinases | 2017 |
[Pharmacokinetics and tissue distribution of α-hederin sodium salt in rats].
Topics: Administration, Oral; Animals; Liver; Oleanolic Acid; Rats; Saponins; Tandem Mass Spectrometry; Tissue Distribution | 2016 |
α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells.
Topics: Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Humans; Interleukin-6; Janus Kinase 2; Oleanolic Acid; Saponins; Signal Transduction; STAT3 Transcription Factor | 2018 |
The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells.
Topics: Apoptosis; Autophagosomes; Autophagy; Carcinoma, Non-Small-Cell Lung; Cathepsins; Cell Line, Tumor; Cell Proliferation; Humans; Hydrogen-Ion Concentration; Lung Neoplasms; Lysosomes; Oleanolic Acid; Paclitaxel; Reactive Oxygen Species; Saponins; Tubulin Modulators | 2018 |
Alpha-Hederin Nanopore for Single Nucleotide Discrimination.
Topics: Molecular Dynamics Simulation; Nanopores; Nanotechnology; Nucleotides; Oleanolic Acid; Polymers; Saponins | 2019 |
α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; HCT116 Cells; Humans; Male; Mice; Neoplasm Transplantation; Oleanolic Acid; Reactive Oxygen Species; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Integration of targeted metabolite profiling and sequential optimization method for discovery of chemical marker combination to identify the closely-related plant species.
Topics: Biomarkers; Chromatography, Liquid; Flowers; Least-Squares Analysis; Lonicera; Metabolomics; Oleanolic Acid; Plants, Medicinal; Saponins; Species Specificity; Tandem Mass Spectrometry | 2019 |
α-Hederin Induces Apoptosis of Esophageal Squamous Cell Carcinoma via an Oxidative and Mitochondrial-Dependent Pathway.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Flow Cytometry; Humans; In Situ Nick-End Labeling; In Vitro Techniques; Male; Membrane Potential, Mitochondrial; Mice, Nude; Mitochondria; Neoplasm Transplantation; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Xenograft Model Antitumor Assays | 2019 |
Alpha-Hederin, the Active Saponin of
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Mitochondria; Nigella sativa; Oleanolic Acid; Saponins | 2019 |
Combining α-Hederin with cisplatin increases the apoptosis of gastric cancer in vivo and in vitro via mitochondrial related apoptosis pathway.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Oleanolic Acid; Reactive Oxygen Species; Saponins; Signal Transduction; Stomach Neoplasms | 2019 |
α-Hederin induces the apoptosis of gastric cancer cells accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Stomach Neoplasms | 2020 |
Topological analysis of single-stranded DNA with an alpha-hederin nanopore.
Topics: Biosensing Techniques; DNA, Single-Stranded; Nanopores; Oleanolic Acid; Saponins; Sequence Analysis, DNA | 2021 |