oleanolic acid has been researched along with beta-escin in 1290 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (4.81) | 18.7374 |
| 1990's | 239 (18.53) | 18.2507 |
| 2000's | 293 (22.71) | 29.6817 |
| 2010's | 535 (41.47) | 24.3611 |
| 2020's | 161 (12.48) | 2.80 |
| Authors | Studies |
|---|---|
| Butterworth, KR; Evans, JG; Gaunt, IF; Grasso, P; Phillips, JC | 1 |
| Becchi, M; Bruneteau, M; Combier, H; Michel, G; Sartre, J; Trouilloud, M | 1 |
| Franke, P; Hiller, K; Nguyen, KQ | 1 |
| Iwashima, A; Kokumai, M; Konoshima, T; Kozuka, M; Nishino, H; Tokuda, H | 1 |
| Chen, FK; Guo, YZ; Kano, Y; Meng, XS | 1 |
| Bahuguna, S; Kikuchi, T; Sati, OP; Uniyal, SK | 1 |
| Christ, B; du Sorbier, BM; Fischer, H; Frechet, D; Vuilhorgne, M | 1 |
| Anton, R; Guéchot, C; Haag-Berrurier, M; Jiang, YL; Lavaud, C; Massiot, G; Teulon, JM | 1 |
| Ikuta, A; Kubota, K; Morikawa, A | 1 |
| Khanna, NM; Malaviya, N; Pal, R | 1 |
| Mahato, SB | 1 |
| Johne, S; Lavaud, C; Lien, NT; Massiot, G; Preiss, A; Schmidt, J; Seifert, K | 1 |
| Yi, YH | 4 |
| Pachaly, P; Shukla, YN; Thakur, RS | 1 |
| Liu, JQ; Wang, G; Xue, SR | 1 |
| Hashimoto, T; Takagi, T; Tsurumi, S | 1 |
| Arihara, S; Endo, K; Shoji, N; Takei, M; Umeyama, A | 1 |
| Hu, SZ; Liu, JQ; Shi, JQ; Wang, G; Wu, QJ; Xue, SR | 1 |
| Du, X; Liu, M | 1 |
| Campbell, JB; Peerbaye, YA | 1 |
| Chen, YJ; Gu, XH; Jiang, YT; Miao, ZC; Ren, L; Xu, SX; Yao, XS | 1 |
| Jia, XS; Klaassen, CD; Liu, J; Liu, YP; Madhu, C; Mao, Q | 1 |
| Jia, XS; Klaassen, CD; Liu, J; Liu, YP; Mao, Q | 1 |
| Chi, Q; Dang, Q; Guo, J | 1 |
| Badoni, V; Sati, OP; Uniyal, SK | 1 |
| Chmurny, GN; Hilton, BD; Woo, EH; Woo, WS | 1 |
| Nagao, T; Okabe, H | 1 |
| Abe, H; Ushio, Y | 4 |
| Maotian, W; Shanhai, H; Xiongtai, G; Xiuwen, H | 1 |
| Abe, H; Oda, Y; Ushio, Y | 1 |
| Cai, LN; Cheng, JR; Huang, LR; Qiao, L; Wang, B; Zhang, RY; Zhang, ZL | 1 |
| Chuang, CH; Lin, CC; Liu, SY; Yen, MH | 1 |
| Du, X; Jiang, C; Liu, M | 1 |
| Fang, J; Zheng, QY | 1 |
| Dini, A; Rastrelli, L; Saturnino, P; Schettino, O | 1 |
| Arihara, S; Narui, T; Okuyama, T; Wang, JD; Yoshikawa, K | 1 |
| Chang, WC; Hsu, FL | 1 |
| Cai, H; Ji, J; Lu, XZ; Luo, HW | 1 |
| Hattori, T; Ito, M; Suzuki, Y | 1 |
| Fukaya, C; Hashimoto, Y; Ikeda, Y; Kawanishi, K; Moriyasu, M; Sugiura, M; Yokoyama, K | 1 |
| Bader, G; Kulhanek, Y; Ziegler-Böhme, H | 1 |
| Hayashi, T; Horii, I; Nakayama, Y; Nishiyama, T; Ozawa, T | 1 |
| Huang, X; Yi, YH | 1 |
| Kawakita, T; Kumazawa, Y; Nomoto, K; Takimoto, H | 1 |
| Sha, ZF; Sun, WJ; Zhang, DK; Zhang, HL; Zhang, XL | 1 |
| Kanazawa, H; Matsushima, Y; Nagata, Y; Takai, N; Tomoda, M | 1 |
| Wang, CL; Yi, YH | 1 |
| Amagaya, S; Nose, M; Ogihara, Y | 2 |
| Achard-Elleouk, S; Braut-Boucher, F; el Badaoui, H; Henry, M; Hoellinger, H; Pauthe'Dayde, D | 1 |
| Dong, YY; Luo, SQ | 1 |
| Jia, Q; Zhang, RY | 1 |
| Kawakita, T; Kumazawa, Y; Nishimura, C; Nomoto, K; Takimoto, H | 1 |
| Jia, XS; Mao, Q | 1 |
| Abe, H; Arichi, S; Konishi, H; Odashima, S; Orita, M | 2 |
| Arichi, S; Hashimoto, M; Inada, K; Kimura, Y; Ohminami, H; Okuda, H | 1 |
| Zhang, J | 1 |
| Zhang, WX | 1 |
| Jyumonji, N; Kohno, H; Odashima, S; Yamaguchi, N; Yamazaki, M | 1 |
| Díaz Villar, L; Peñafiel, CC | 1 |
| Jin, RL; Kuang, Y; Shi, L | 1 |
| Fairweather-Tait, SJ; Fenwick, GR; Price, KR; Southon, S; Wright, AJ | 1 |
| Baumann, H; Jansakul, C; Kenne, L; Samuelsson, G | 1 |
| Han, DX; Han, JW; Qiao, M; Tan, WJ; Xu, SX; Yu, ZC | 1 |
| Hiai, S; Yokoyama, H | 2 |
| Amagaya, S; Iwama, H; Ogihara, Y | 1 |
| Fujimura, H; Kubomura, Y; Miki, K; Yamahara, J | 1 |
| Motomura, H; Sakuma, S | 1 |
| Dubois, MA; Ilyas, M; Wagner, H | 1 |
| Fujiwara, K; Ogihara, Y | 1 |
| Abe, H; Kohno, H; Odashima, S; Tawara, M; Yamaguchi, N | 1 |
| Ohuchi, K; Ozeki, T; Tsurufuji, S; Watanabe, M | 1 |
| Ito, K; Kimata, H; Matsufuji, N; Morita, T; Sumida, N; Tanaka, O; Yata, N | 1 |
| Amagaya, S; Ogihara, Y; Shimizu, K | 2 |
| Liu, AJ; Wang, BZ; Wang, GZ | 1 |
| Li, XZ | 1 |
| Chang, XL | 1 |
| Ma, JL; Wang, GZ; Zhou, ZC | 1 |
| Arichi, S; Hayashi, T; Kimura, Y; Ohminami, H; Okuda, H; Tani, T | 1 |
| Hiraoka, E; Hirotani, Y; Kishi, H; Maeda, Y; Oishi, M; Yamaji, A; Yoneda, K | 1 |
| Wang, ZL; Yi, YH | 1 |
| Chen, YJ; Iitaka, Y; Ogihara, Y; Takeda, T | 1 |
| Han, DW; Li, CM; Ma, XH; Yin, L; Zhao, MQ; Zhao, YC | 1 |
| Hiai, S; Oura, H; Yokoyama, H | 2 |
| Anisimov, MM; Antonov, VF; Ivanov, AS; Korepanova, EA; Popov, AM | 1 |
| Abe, H; Arichi, S; Odashima, S; Sakaguchi, M | 1 |
| Pourrat, H; Regerat, F; Texier, O | 1 |
| Abe, H; Arichi, S; Sakaguchi, M | 1 |
| Abe, H; Arichi, S; Odashima, S; Sakaguchi, M; Yamada, M | 1 |
| Abe, H; Anno, M; Arichi, S; Sakaguchi, M | 1 |
| Hiai, S; Nagasawa, T; Oura, H; Yokoyama, H | 1 |
| Abe, H; Arichi, S; Komiya, H; Konishi, H | 1 |
| Hase, J; Kobashi, K; Mitsui, K; Namba, T; Tomimori, T; Yoshizaki, M | 1 |
| Kato, H; Park, EH; Takagi, K | 1 |
| Hata, T; Itoh, E; Kita, T; Yoneda, R | 1 |
| Cordell, GA; Lin, LZ; Shao, Y; Zhou, BN | 1 |
| Ahmad, VU; Mohammad, FV; Noorwala, M; Sener, B | 2 |
| Cui, ZH; Hanquet, B; Lacaille-Dubois, MA; Lou, ZC; Wagner, H | 3 |
| Ida, Y; Katsumata, M; Nagasao, M; Satoh, Y; Shoji, J | 1 |
| Ahmad, VU; Mohammad, FV; Noorwala, M | 1 |
| Lin, CC; Liu, SY; Son, LM; Wang, JY; Wu, WK; Yen, MH | 1 |
| Fujimoto, Y; Hara, N; Jayasinghe, L; Shimada, H | 1 |
| Arao, T; Isobe, R; Kinjo, J; Nohara, T | 2 |
| Ma, K; Shao, Y; Wu, HM; Zhou, BN | 1 |
| Hattori, T; Isobe, K; Kato, M; Nakashima, I; Pu, MY; Yanagita, N | 1 |
| Cordell, GA; Lin, L; Ma, K; Shao, Y; Wu, H; Zhou, B | 1 |
| Ji, NN; McKervey, MA; Ou, BX; Stevenson, P; Ye, T; Ye, WC; Zhao, SX | 1 |
| Kersten, GF; van de Werken, G; van Setten, DC; Zomer, G | 1 |
| Liu, GT; Shi, JZ | 2 |
| Chirva, VIa; Grishkovets, VI; Shashkov, AS; Tsvetkov, OIa | 1 |
| Bullock, P; Klaassen, CD; Liu, J; Liu, Y | 1 |
| Li, Q; Murakamio, T; Okita, K; Takahashi, M | 1 |
| Addy, ME; Burka, JF; Feigenbaum, P; Garcia, ML; Giangiacomo, KM; Harris, GH; Kaczorowski, GJ; McManus, OB; Reuben, JP | 1 |
| Ganetzky, B; Helms, LM; Leonard, RJ; McManus, OB; Pallanck, L; Swanson, R | 1 |
| Giner, RM; Hostettmann, K; Just, MJ; Mañez, S; Recio, MC; Rios, JL | 1 |
| Hiller, K; Nimtz, M; Schöpke, T; Thiele, H; Wray, V | 2 |
| Aftab, K; Ahmad, VU; Gilani, AH; Mohammad, FV; Noorwala, M; Sener, B | 1 |
| Nie, RL; Qiu, MH; Tian, J; Wu, FE | 1 |
| Ahmad, VU; Baqai, FT; Mohammad, FV; Shah, MG | 1 |
| Bahuguna, RP; Thapliyal, RP | 2 |
| Maeda, T; Miyase, T; Suzuki, H; Ueno, A; Yamamoto, A | 1 |
| Hanquet, B; Lacaille-Dubois, MA; Rustaiyan, A; Wagner, H | 1 |
| Ida, Y; Isoda, S; Miyakoshi, M; Sawada, H; Shoji, J | 1 |
| Mayer, R; Rücker, G; Wang, HB | 1 |
| Chen, YZ; Wang, MK; Wu, FE | 1 |
| Cheng, D; Shao, Y | 1 |
| Asada, Y; Furuya, T; Ikeno, M | 1 |
| Hartleb, I; Seifert, K | 1 |
| Ida, Y; Katsumata, M; Miyakoshi, M; Nagasao, M; Sakai, S; Satoh, Y; Shoji, J | 2 |
| Kim, JH; Okubo, K; Yoshiki, Y | 1 |
| Miyase, T; Mori, F; Ueno, A | 1 |
| Anil, H; Kirmizigül, S | 1 |
| Jia, Z; Koike, K; Ni, M; Ohmoto, T | 1 |
| Mahato, SB; Sahu, NP | 1 |
| Kim, JH; Nagoya, I; Okubo, K; Sakabe, T; Tamura, N; Yoshiki, Y | 1 |
| Ma, K; Qin, G; Shao, B; Wu, H; Xu, R | 1 |
| Cornett, C; Furu, P; Jørstian, CL; Knudsen, AD; Lemmich, E; Olsen, CE; Salih, A; Thilborg, ST | 1 |
| Kimura, Y; Murakami, T; Okita, K; Qian, L; Takahashi, M | 1 |
| Fang, ZP; Zeng, XY; Zhou, YX | 1 |
| Hattori, T; Isobe, K; Iwamoto, T; Kato, M; Lwin, T; Nagase, F; Nakashima, I; Pu, MY; Yanagita, N; Zhang, YH | 1 |
| Anil, H; Calişkan, OA; Stephenson, GR | 1 |
| Fang, J; Guan, XJ; Ju, DW; Wang, HB; Yi, YH; Zheng, QY | 1 |
| Frøkiaer, H; Møller, P; Sørensen, H; Sørensen, S | 1 |
| Cai, YC; Liang, L; Lu, LE | 1 |
| Feng, R; Miao, ZC; Wang, XJ; Zhang, QH | 1 |
| Hu, ZL; Qian, DH; Yi, YH; Zhang, JP | 1 |
| Huang, SL; Wang, XJ; Zhang, QH | 1 |
| Chang, TY; Hung, CR; Wu, TS | 1 |
| Harada, E; Matsuda, H; Murakami, N; Murakami, T; Wariishi, N; Yamahara, J; Yoshikawa, M | 1 |
| Angenot, L; Balansard, G; Bassleer, R; Coucke, P; Danloy, S; De Pauw-Gillet, MC; Elias, R; Quetin-Leclercq, J | 1 |
| Cao, D; Jia, XS; Mao, Q | 1 |
| Chen, WZ; Hori, K; Kitagawa, I; Ren, J; Uchida, E; Yoshikawa, M | 1 |
| Chen, XK; Jiang, TY; Wang, B; Zhang, RY; Zhang, ZL | 1 |
| Jiang, Y; Ma, XY; Qi, H; Zhong, GG | 1 |
| Ahmad, VU; Shah, MG | 1 |
| De Simone, F; De Tommasi, N; Piacente, S; Pizza, C; Zhou, ZL | 1 |
| Maeda, T; Miyase, T; Ueno, A; Yamamoto, A | 2 |
| Do, JC; Jung, KY; Son, KH | 1 |
| Andrews, GK; Choudhuri, S; Klaassen, CD; Kreppel, H; Liu, J; Liu, Y | 1 |
| Ishihara, K; Ito, K; Kosuge, E; Kuriyama, M; Nakamura, T | 1 |
| Ding, SL; Zhu, ZY | 1 |
| Ebashi, J; Furumoto, T; Isiguro, I; Nagamura, Y; Nishida, K; Saito, S; Sumita, S | 1 |
| Ishihara, S; Komoda, Y; Suzuki, K; Uchida, M | 1 |
| Frøkiaer, H; Sørensen, H; Sørensen, JC; Sørensen, S | 1 |
| Ashida, K; Hasegawa, C; Minami, M; Ohe, C; Sugino, M; Yomo, T | 1 |
| Andoh, T; Miyase, T; Ueno, A | 1 |
| Dobashi, I; Horiba, N; Sakai, K; Sakai, Y; Suda, T; Tozawa, F | 1 |
| Iszard, MB; Klaassen, CD; Liu, J | 1 |
| Matsuda, H; Murakami, N; Murakami, T; Ueno, T; Yamahara, J; Yoshikawa, M; Yoshizumi, S | 1 |
| Kadoya, M; Matsuda, H; Murakami, N; Murakami, T; Ueno, T; Yamahara, J; Yoshikawa, M | 1 |
| Hu, CQ; Kashiwada, Y; Kitanaka, S; Yasuda, I | 1 |
| Fujikawa-Yamamoto, K; Odashima, S; Tanino, M; Teraoka, K; Yamagishi, H; Zong, Z | 1 |
| Fukuda, K; Kojiro, M; Ohtsuka, M; Yano, H | 1 |
| Amara-Mokrane, YA; Balansard, G; Botta, A; Duménil, G; Lehucher-Michel, MP | 1 |
| Cates, RG; Grant, DM; Jia, Z; Li, D; Liu, Z; Owen, NL | 1 |
| Pan, Q; Shi, Y; Yang, P | 1 |
| Lee, MS; Qin, G; Vaisar, T; Xu, R; Zhao, W | 1 |
| Chen, M; Nanz, D; Sticher, O; Wu, WW | 1 |
| Fenwick, GR; Price, KR; Rhodes, MJ; Ruiz, RG | 1 |
| Harada, E; Matsuda, H; Murakami, N; Murakami, T; Yamahara, J; Yoshikawa, M | 2 |
| Arao, T; Idzu, T; Isobe, R; Kinjo, J; Nohara, T | 1 |
| Chen, LF; Chou, CH; Kim, D; Lee, JS; Lee, MR; Liou, RM; Su, CH; Waller, GR; Wu, SC; Yang, CF; Young, CC | 1 |
| Abubakirov, NK; Isaev, MI; Timbekova, AE | 1 |
| Lee, JS; Lee, MR; Waller, GR; Wang, JC | 1 |
| Jurzysta, M; Lee, MK; Ling, YC; Waller, GR | 1 |
| Kuang, HX; Okada, Y; Okuyama, T; Sun, H; Zhang, N | 1 |
| Aftab, K; Ahmad, VU; Mohammad, FV; Noorwala, M; Shaheen, F | 1 |
| Do, JC; Jung, KY; Kim, YH; Lee, KH; Son, KH; Song, DK; Suh, HW; Wie, MB | 1 |
| Chin, CK; Cordell, GA; Ho, CT; Poobrasert, O; Shao, Y | 1 |
| Charrouf, Z; Guillaume, D; Kol, O; M'Bark, AN | 1 |
| Anton, R; Charrouf, Z; Guillaume, D; Kirchner, V; Lobstein, A; Oulad-Ali, A; Weniger, B | 1 |
| Daros, Mdo D; Matos, FJ; Parente, JP | 1 |
| Chin, CK; Ho, CT; Hu, B; Qin, GW; Rosen, RT; Shao, Y | 1 |
| Ding, WP; Fang, T; Jiang, C; Ma, B; Ma, K; Ni, J; Wu, H | 1 |
| Jia, Z; Koike, K; Nikaido, T; Sahu, NP | 1 |
| Alaçam, R; Caliş, T; Demirdamar, R; Kelican, P; Rüegger, H; Satana, ME; Sticher, O; Tanker, N; Yürüker, A | 1 |
| al-Tawaha, C; Hiller, K; Nimtz, M; Schöpke, T; Wray, V | 1 |
| Hayashi, H; Hayashi, K; Hiraoka, N; Ikeshiro, Y | 1 |
| Komatsu, H; Matsuda, H; Nishida, N; Sakurama, T; Shimada, H; Shimoda, H; Tani, T; Yamahara, J; Yoshikawa, M | 1 |
| Kawachi, H; Li, P; Morioka, T; Oite, T; Orikasa, M; Shi, ZS; Shimizu, F | 1 |
| Aumelas, A; Bonnet, PA; Delay, C; Gavin, JA; Roumestand, C | 1 |
| Chin, CK; Cordell, GA; Ho, CT; Poobrasert, O; Shao, Y; Yang, SW | 1 |
| Knaus, HG; Meera, P; Song, M; Tanaka, Y; Toro, L | 1 |
| Hori, K; Matsuda, H; Matsumura, N; Morikawa, T; Murakami, T; Shimada, H; Yamahara, J; Yoshikawa, M; Yoshizumi, S | 1 |
| Matsushima, Y; Miyase, T | 1 |
| Arda, N; Cordell, GA; Gören, N; Kuru, A; Pengsuparp, T; Pezzuto, JM; Qiu, SX | 1 |
| Itokawa, H; Morita, H; Shimizu, K; Shirota, O; Takeya, K; Yun, YS | 1 |
| Horikoshi, C; Kusano, G; Melek, FR; Miyasaka, S; Miyase, T; Yabe, S | 1 |
| Gromova, AS; Li, D; Lutsky, VI; Owen, NL; Semenov, AA | 1 |
| Hoang, MC; Kasai, R; Nguyen, TN; Ohtani, K; Vo, DH; Yamamura, S; Yamasaki, K | 1 |
| Kuroyanagi, M; Miyase, T; Noguchi, H; Umehara, K; Zhang, D | 1 |
| Akao, T; Hattori, M; Kida, H; Meselhy, MR | 2 |
| Baines, D; Daston, GP; Duffy, JY; Keen, CL; Overmann, GJ | 1 |
| Arao, T; Kinjo, J; Miyao, H; Nohara, T; Udayama, M | 1 |
| Hiller, K; Janka, M; Nimtz, M; Schöpke, T; Wray, V | 1 |
| Kashimoto, T; Kudo, K; Tachikawa, E; Takahashi, E | 1 |
| Aquino, R; De Simone, F; De Tommasi, N; Gacs-Baitz, E; Piacente, S; Pizza, C | 1 |
| Kinjo, J; Nohara, T; Udayama, M; Yoshida, N | 1 |
| Amsden, J; Anderson, CA; Kensil, CR; Wheeler, DA; Wu, JY | 1 |
| Cao, X; Fang, J; Ju, DW; Wang, HB; Zheng, QY | 1 |
| Bae, EA; Choi, JW; Kim, DH; Park, HJ; Yu, KW | 1 |
| Baltaci, C; Genç, H; Küçük, M; Küçükislamoğlu, M; Yayli, N; Zengin, A | 1 |
| Komatsu, H; Matsuda, H; Murakami, T; Yoshikawa, M | 1 |
| Guo, S; Kenne, L; Lundgren, LN; Rönnberg, B; Sundquist, BG | 1 |
| Jeong, HG; Park, HY | 1 |
| Jia, Z; Koike, K; Kudo, M; Li, H; Nikaido, T | 1 |
| Baltaci, C; Genc, H; Kuçukislamoglu, M; Yayli, N; Zengin, A | 1 |
| Kojima, K; Ogihara, Y; Zhu, XB | 1 |
| Kinjo, J; Nohara, T; Udayama, M | 1 |
| Ebizuka, Y; Jung, DW; Shibuya, M; Shimomura, K; Sung, CK; Yoshimatsu, K | 1 |
| Giangiacomo, KM; Harris, G; Kamassah, A; McManus, OB | 1 |
| Abad Martínez, MJ; Bermejo Benito, P; Díaz Lanza, AM; Fernández Matellano, L; Sánchez Contreras, S; Sanz Gómez, A; Silván Sen, AM | 1 |
| Hiai, S; Nagasawa, T; Zhang, ZQ; Zhou, QL | 1 |
| Kinjo, J; Nohara, T; Ohkawa, M; Udayama, M; Yoshida, N | 1 |
| Jiang, Y; Jing, H; Luo, S | 1 |
| Jeong, HG | 1 |
| Bang, KH; Kim, DW; Lee, KT; Park, HJ; Rhee, YH | 1 |
| Fujikawa-Yamamoto, K; Guan, X; Li, A; Murakami, M; Odashima, S; Ota, T; Tanino, M; Yamaguchi, N; Zong, Z | 1 |
| Jung, DW; Sung, CK | 1 |
| Hori, K; Kitagawa, I; Motozawa, T; Murakami, T; Yoshikawa, M | 1 |
| Nimtz, M; Schöpke, T; Ueckert, J; Wray, V | 1 |
| Cai, S; Tan, L; Tu, G; Wang, B; Zhang, R; Zhao, Y | 1 |
| Elias, R; Favel, A; Moulin-Traffort, J; Regli, P | 1 |
| Liu, J; Liu, YP | 1 |
| Jia, Z; Koike, K; Nikaido, T | 1 |
| Hahn, DR; Park, MJ | 1 |
| Cho, SH; Hahn, DR | 1 |
| Li, XC; Qi, SB; Ruan, HZ; Wang, J; Wang, XY; Zhang, L; Zhou, YL | 1 |
| Glensk, M; Nimtz, M; Schöpke, T; Wray, V | 1 |
| Jeong, HG; Lee, SS | 1 |
| Desbène, S; Hanquet, B; Lacaille-Dubois, MA; Shoyama, Y; Wagner, H | 1 |
| Koike, K; Mitsunaga, K; Nikaido, T; Saeki, T | 1 |
| Chang, HW; Kang, SS; Kim, HP; Kim, SY; Son, KH | 1 |
| Ahn, KS; Jung, KY; Lee, HK; Lee, IS; Oh, SR; Park, SH; Son, KH | 1 |
| Takaishi, Y; Yeşilada, E | 1 |
| Li, YQ; Lin, HW; Tang, HF; Wang, ZZ; Xiao, K; Yi, YH | 1 |
| Li, Y; Matsuda, H; Yoshikawa, M | 1 |
| Ahn, KS; Jung, KY; Kim, JG; Lee, HK; Lee, IS; Lee, JJ; Oh, SR; Park, SH | 1 |
| De Méo, M; Duménil, G; Elias, R; Guiraud-Dauriac, H; Laget, M; Mba Gachou, C | 1 |
| Bauer, R; Chauffert, B; Correia, M; Gaidi, G; Hanquet, B; Lacaille-Dubois, MA; Marouf, A | 1 |
| Bader, G; Hiller, K; Seibold, M; Tintelnot, K | 1 |
| Hirakawa, T; Kinjo, J; Nohara, T; Okawa, M | 1 |
| Murayama, T; Shoji, J; Wang, G; Xu, J | 1 |
| Kodama, Y; Kubo, M; Kyo, R; Nakahata, N; Nakai, Y; Ohizumi, Y | 1 |
| Berhow, MA; Plewa, MJ; Vaughn, SF; Wagner, ED | 1 |
| Lee, DK; Park, S; Whang, YH; Yang, CH | 1 |
| Abdel-Gawad, MM; El-Amin, SM; Kawanaka, M; Ohigashi, H; Sugiyama, H; Takeda, N; Watanabe, Y | 1 |
| Kenne, L; Nyberg, NT; Rönnberg, B; Sundquist, BG | 1 |
| Falk, E; Guo, S; Kenne, L; Rönnberg, B; Sundquist, BG | 1 |
| Bedir, E; Caliş, I; Kirmizipekmez, H; Sticher, O | 1 |
| Azas, N; Dekanosidze, G; Delmas, F; Di Giorgio, C; Elias, R; Gasquet, M; Kemertelidze, E; Mshvildadze, V; Timon-David, P | 1 |
| Kang, EM; Kim, N; Park, IS | 1 |
| Huh, S; Kim, Y; Son, K; Song, D; Suh, H | 1 |
| Hirakawa, T; Kinjo, J; Nohara, T; Shii, Y; Uyeda, M; Yokomizo, K | 1 |
| Girault, JP; Lafont, R; Saatov, Z; Sadikov, ZT | 1 |
| Anchev, M; De Rosa, S; Handjieva, N; Mitova, M; Popov, S | 1 |
| Guo, S; Kenne, L | 2 |
| Hirakawa, T; Ikeda, T; Kinjo, J; Nohara, T; Okawa, M; Shii, Y; Udayama, M | 1 |
| Huang, J; Ogihara, Y; Shimizu, N; Takeda, T; Zhang, H | 1 |
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| Dai, Z; Fan, F; Li, G; Li, W; Ma, X; Qian, Z; Wang, D; Zhang, A; Zhang, X | 1 |
| Li, F; Ma, CL; Qu, MH; Wang, GS; Wang, YX; Wu, ST; Yu, BH | 1 |
| Haddad, M; Lavedan, P; Le Doux Kamto, E; Mbing, JN; Messi, LM; Moffi Biang, AE; Noté, OP; Pegnyemb, DE; Simo, LM; Vedrenne, M | 1 |
| Cai, T; Chen, X; Cheng, J; Cheng, Z; Qi, S; Qi, Z; Wang, S; Wu, X | 1 |
| Cheng, YL; Guo, YH; Wei, MP; Xie, YF; Yao, WR; Yu, H | 2 |
| Chen, G; Fu, Y; Yao, L; Yao, T; Zhang, L; Zhou, C | 1 |
| Hu, Q; Li, J; Sun, X; Yan, H; Yang, Y; Zhao, C; Zuo, Z | 1 |
| Du, M; Li, F; Tian, Y; Xiao, M; Zhang, W; Zhang, X | 1 |
| Chen, CR; Huang, ZL; Jiang, S; Qu, WM; Zhang, W; Zhong, YH | 1 |
| Cheng, T; Ying, M | 1 |
| Cao, J; Fang, C; Hao, G; He, Q; Hong, W; Qiu, Y; Shao, Y; Shi, Q; Song, L; Wang, J; Weng, Q; Yang, B; Yang, L; Yang, Z; Zhang, L | 1 |
| Du, QY; Guo, J; He, XY; Shi, W; Wang, F; Zhou, P | 1 |
| Chen, Y; Li, Y; Lin, L; Que, R; Zhang, N; Zhou, M | 1 |
| He, YM; Li, XX; Liu, CQ; Luo, Y; Wu, XC; Yang, MT; Yuan, CF; Zhou, ZY | 1 |
| Feng, Z; Fu, X; Guo, X; Hou, X; Ji, J; Luo, Y; Mei, Z; Zhang, J | 1 |
| Choi, CI; Han, HK; Lee, HS; Lim, SH | 1 |
| Nguyen, KP; Nguyen, TA; Nguyen, TH; Pham, NK; Thai, HM; Vo, TN | 1 |
| Hu, ZY; Luo, XJ; Peng, J; Peng, YW; Peng, ZM; Ren, KD; Tian, J; Zhang, XJ; Zhang, YY | 1 |
| Liu, B; Sun, G; Sun, X; Wang, M; Wang, R; Xu, H; Ye, J | 1 |
| Chen, H; Feng, L; He, Y; Hou, D; Wei, P; Yang, B; Yang, Y; Yu, M; Zhang, Y; Zhao, J | 1 |
| Khan, MI; Khan, MZ; Kim, JD; Kim, MY; Lee, YB; Shin, JH; Shin, TS | 1 |
| Chen, K; Gao, M; Jiang, H; Li, H; Ye, C; Yu, K | 1 |
| Ramsue, LK; Roberson, J; Song, BH; Yates, PS | 1 |
| Chen, H; Chen, L; Fang, X; Lu, F; Song, X; Sun, J; Wu, X; Zhang, W; Zhao, K | 1 |
| Kiuchi, F | 1 |
| Chen, XM; Cheng, YF; Jiang, W; Li, X; Luo, D; Pi, JK; Wang, XJ; Wang, XX; Wu, SS; Wu, Z; Xu, JY; Zhang, Y; Zhang, YJ; Zhou, JH | 1 |
| Du, J; Huang, X; Li, B; Li, L; Li, Y; Liu, J; Song, D | 1 |
| Dai, Z; Sun, G; Sun, X; Wang, M; Wang, R; Zhou, J | 1 |
| Miao, H; Pan, J; Shen, N; Xing, L; Yu, X; Zhang, H; Zou, L | 1 |
| Hu, R; Yin, X; Zhou, Y; Zhu, W | 1 |
| Huang, W; Liu, J; Luo, J; Tan, W; Wang, J; Xin, H; Yang, J | 1 |
| Arbeláez, N; Archbold, R; Echeverri, F; Escobar, G; Higuita-Castro, JL; Montoya, A; Piragauta, SP; Quiñones, W; Restrepo, AM; Robledo, SM; Torres, F; Vélez, ID | 1 |
| Chianese, G; Masi, F; Peterlongo, F; Riva, A; Taglialatela-Scafati, O | 1 |
| Liang, J; Wang, CZ; Wang, X; Yuan, CS; Yuan, E; Zeng, J; Zhang, C; Zhong, Y; Zhou, L; Zhu, J | 1 |
| Cao, L; Fang, Z; Jia, D; Mi, J; Pan, Z; Peng, P; Shi, Z; Zhang, Y | 1 |
| Bellaye, PS; Collin, B; Delaude, C; Lacaille-Dubois, MA; Mitaine-Offer, AC; Miyamoto, T; Pertuit, D; Tanaka, C | 1 |
| Gao, J; Guo, X; Han, W; Sui, C; Wan, H; Wei, J; Wu, B; Xu, J; Zhou, L | 1 |
| Bera, M; Mukhopadhyay, B | 1 |
| Chen, BL; Wang, P; Wen, XQ; Wu, WW; Yu, CL; Zhang, HY; Zhang, JW; Zhang, MY; Zhang, Y; Zhou, Q; Zhuang, M | 1 |
| Ahn, SS; Jung, E; Lee, YH; Lim, Y; Shin, SY; Yeo, H | 1 |
| Im, WT; Kim, JH; Lee, JE; Siddiqi, MZ; Song, BK | 1 |
| Ding, M; Duan, S; Fan, G; Gu, Y; Li, X; Li, Y; Liu, C; Liu, R; Sun, R; Zheng, Q | 1 |
| Bu, Y; Guo, J; Hu, J; Li, B; Li, J; Zhang, H; Zhang, Y | 1 |
| Amen, Y; Nagata, M; Othman, A; Shimizu, K | 1 |
| Huang, R; Lin, Q; Liu, Z; Xia, X; Yang, J; Zeng, J; Zhao, N | 1 |
| Cheng, Y; Wang, Y; Wu, Y; Xiang, Z; Yu, X | 1 |
| Jiao, ZY; Xiao, LX; Zhou, HN | 1 |
| Kim, SH; Kwon, IK; Lee, JY; Park, KR; Yun, HM | 1 |
| Du, G; Gao, X; Hou, R; Li, X; Qin, X; Tian, J; Wu, X; Wu, Y; Zhou, Y | 1 |
| Dong, C; Ji, B; Qiao, L; Su, X; Yang, L | 1 |
| Han, RY; Jia, J; Liu, XH; Tan, RZ; Wang, L; Xie, KH; Zhong, X | 1 |
| Huang, Q; Li, LL; Peng, DY; Qi, JJ; Yao, M | 1 |
| Guan, M; Hu, X; Li, B; Li, S; Liu, M; Liu, S; Ning, X; Song, G; Wan, X; Wang, J | 1 |
| Chen, Y; Cui, N; Hu, B; Kuang, H; Peng, D; Qi, Y; Sun, Y; Wang, Q; Yang, B; Zeng, Y; Zhang, W; Zhang, Z | 1 |
| Li, L; Li, SG; Li, W; Li, X; Li, ZS; Xiong, Y; Xiong, YY; Yang, LJ; Ye, AY; Zhang, Y | 1 |
| Anh Bang, N; Hai Yen, P; Huu Tai, B; Thi Cuc, N; Thi Hai Yen, D; Thi Huyen, L; Thi Thu Hien, T; Van Kiem, P; Xuan Nhiem, N | 1 |
| Jiang, L; Khan, MR; Ni, ZJ; Tang, TT; Thakur, K; Wei, ZJ; Zhong, Q | 1 |
| DU, XW; Hou, BY; Wang, WX; Yu, D; Zhu, HR | 1 |
| Bellaye, PS; Briand, L; Bruguière, A; Collin, B; Dias, AMM; Hovhannisyan, N; Mitaine-Offer, AC; Miyamoto, T; Nazaryan, S | 1 |
| Lai, Y; Zhu, Y | 1 |
| Alejo-Jacuinde, G; Alolga, RN; Cai, YY; Chen, X; Chen, Y; Ding, H; Du, J; Gao, W; Guo, D; Herrera-Estrella, L; Huang, FQ; Kan, X; Li, P; Lu, X; Qi, LW; Tran, LP; Wang, X; Wei, X; Xiang, Y; Yin, X; Zhang, B | 1 |
| Chang, Y; Liu, S; Tian, L; Wang, Z; Xiao, Y; Xiu, Y; Zhao, H; Zhao, M; Zhou, Y | 1 |
| Abd-Alla, HI; Abourehab, MAS; Alsaggaf, AT; El-Beeh, ME; El-Mezayen, H; Fujita, M; Otsuka, M; Radwan, MO; Tateishi, H | 1 |
| Adekunle, YA; Fatokun, AA; Nahar, L; Samuel, BB; Sarker, SD | 1 |
| Karwowska, K; Petelska, AD; Urbaniak, W | 1 |
38 review(s) available for oleanolic acid and beta-escin
| Article | Year |
|---|---|
Saponin.
Topics: Adjuvants, Immunologic; Animals; Oleanolic Acid; Quillaja Saponins; Sapogenins; Saponins | 1992 |
Chemistry and biological activity of triterpenoid glycosides from Medicago sativa.
Topics: Bacteria; Fungi; Medicago sativa; Molecular Structure; Oleanolic Acid; Plant Development; Plants; Saponins; Triterpenes | 1996 |
Antidiabetogenic activity of oleanolic acid glycosides from medicinal foodstuffs.
Topics: Animals; Blood Glucose; Gastric Emptying; Gastrointestinal Motility; Glucose; Hypoglycemic Agents; Intestinal Absorption; Mice; Oleanolic Acid; Plants, Edible; Plants, Medicinal; Rats; Receptors, Dopamine; Saponins; Structure-Activity Relationship | 2000 |
[Advances in the studies of saponins from Aralia].
Topics: Analgesics, Non-Narcotic; Animals; Aralia; Drugs, Chinese Herbal; Humans; Hypolipidemic Agents; Oleanolic Acid; Plants, Medicinal; Saponins | 1997 |
Triterpenoids.
Topics: Anti-HIV Agents; Anticholesteremic Agents; Antihypertensive Agents; Dammaranes; Fibrinolytic Agents; Hypoglycemic Agents; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins; Stereoisomerism; Structure-Activity Relationship; Sweetening Agents; Triterpenes | 2001 |
Saponins in cereals.
Topics: Biological Evolution; Disease Susceptibility; Edible Grain; Molecular Structure; Oleanolic Acid; Poaceae; Saponins; Triterpenes | 2003 |
[Advances in the study on medicament portions of caihu].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupleurum; Flavonoids; Humans; Oils, Volatile; Oleanolic Acid; Plant Components, Aerial; Plant Roots; Plants, Medicinal; Saponins; Species Specificity | 1999 |
[Advances in the study of triterpene constituents of Ardisia medicinal plants].
Topics: Animals; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Ardisia; Drugs, Chinese Herbal; Humans; Oleanolic Acid; Plants, Medicinal; Saponins | 2003 |
[Progress in research on antitumor activity of saikosaponin and its mechanism].
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cyclooxygenase 2 Inhibitors; Drugs, Chinese Herbal; Humans; Oleanolic Acid; Saponins | 2006 |
[Advances in the study on medicinal plants of Akebia].
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Diuretics; Drugs, Chinese Herbal; Fruit; Humans; Magnoliopsida; Oleanolic Acid; Plant Stems; Plants, Medicinal; Quality Control; Saponins; Triterpenes | 2006 |
Adjuvant effects of saponins on animal immune responses.
Topics: Adjuvants, Immunologic; Animals; Astragalus Plant; Immune System; ISCOMs; Oleanolic Acid; Panax; Sapogenins; Saponins | 2007 |
Oleanolic acid and related derivatives as medicinally important compounds.
Topics: Animals; Glycosides; Humans; Oleanolic Acid; Pharmaceutical Preparations; Saponins | 2008 |
Current synthesis of triterpene saponins.
Topics: Glycosides; Oleanolic Acid; Polysaccharides; Saponins; Stereoisomerism; Triterpenes | 2009 |
Chemical and biological characterization of oleanane triterpenoids from soy.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Glycine max; Humans; Molecular Structure; Oleanolic Acid; Saponins | 2009 |
[Advances in mechanisms of saikosaponins in preventing and treating liver disease].
Topics: Humans; Liver Diseases; Oleanolic Acid; Phytotherapy; Saponins | 2009 |
Saikosaponins: a potential treatment option for systemic lupus erythematosus.
Topics: Animals; Autoimmune Diseases; Humans; Immunosuppressive Agents; Lupus Vasculitis, Central Nervous System; Oleanolic Acid; Saponins | 2011 |
Putative genes involved in saikosaponin biosynthesis in Bupleurum species.
Topics: Biosynthetic Pathways; Bupleurum; Gene Expression Regulation, Plant; Genes, Plant; Oleanolic Acid; Phylogeny; Saponins | 2013 |
Biological functionality of soyasaponins and soyasapogenols.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Glycine max; Humans; Oleanolic Acid; Plant Extracts; Saponins | 2014 |
The medicinal chemistry of genus Aralia.
Topics: Alkynes; Anti-Inflammatory Agents; Anti-Obesity Agents; Antineoplastic Agents, Phytogenic; Aralia; Biological Products; Cardiotonic Agents; Diterpenes; Hypoglycemic Agents; Immunologic Factors; Lipids; Oleanolic Acid; Plants, Medicinal; Saponins | 2015 |
New biofunctional effects of the flower buds of Camellia sinensis and its bioactive acylated oleanane-type triterpene oligoglycosides.
Topics: Animals; Anti-Obesity Agents; Camellia sinensis; Flowers; Gastrointestinal Agents; Glycosides; Hypoglycemic Agents; Hypolipidemic Agents; Neuroprotective Agents; Oleanolic Acid; Phytotherapy; Plant Extracts; Saponins; Triterpenes | 2016 |
A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Bupleurum; Drugs, Chinese Herbal; Humans; Immunologic Factors; Neurotransmitter Agents; Oleanolic Acid; Phytotherapy; Plants, Medicinal; Saponins | 2017 |
Saponins from seeds of Genus Camellia: Phytochemistry and bioactivity.
Topics: Camellia; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Seeds | 2018 |
Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review.
Topics: Animals; Antioxidants; Benzoquinones; Humans; Lipid Peroxidation; Liver Diseases; Nigella sativa; Oleanolic Acid; Plant Extracts; Protective Agents; Reactive Oxygen Species; Saponins; Superoxide Dismutase | 2018 |
Saikosaponins: a review of pharmacological effects.
Topics: Bupleurum; Drugs, Chinese Herbal; Humans; Molecular Structure; Oleanolic Acid; Plant Roots; Saponins | 2018 |
The Role of Saikosaponins in Therapeutic Strategies for Age-Related Diseases.
Topics: Apoptosis; Cardiovascular Diseases; Cell Cycle Checkpoints; Humans; Liver Diseases; Neoplasms; Neurodegenerative Diseases; Obesity; Oleanolic Acid; Oxidative Stress; Saponins | 2018 |
Triterpenoids.
Topics: Dammaranes; Molecular Structure; Oleanolic Acid; Saponins; Squalene; Triterpenes | 2018 |
A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Apoptosis; Bupleurum; China; Drugs, Chinese Herbal; Fibrosis; Humans; Liver; Oleanolic Acid; Oxidative Stress; Plant Extracts; Saponins | 2018 |
An Insight into Saponins from Quinoa (
Topics: Anti-Inflammatory Agents; Chenopodium quinoa; Chromatography, High Pressure Liquid; Hot Temperature; Oleanolic Acid; Plant Extracts; Saponins; Seeds; Solid Phase Extraction; Sonication; Water | 2020 |
Saikosaponin D: A potential therapeutic drug for osteoarthritis.
Topics: Autophagy; Humans; NF-kappa B; Oleanolic Acid; Osteoarthritis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Recent Progress in Saikosaponin Biosynthesis in Bupleurum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupleurum; Drugs, Chinese Herbal; Flavonoids; Humans; Oleanolic Acid; Plant Roots; Saponins; Species Specificity | 2021 |
Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure.
Topics: Benzoquinones; COVID-19 Drug Treatment; Diabetes Mellitus; Dietary Supplements; Humans; Nigella sativa; Oleanolic Acid; Pandemics; Plant Extracts; Saponins; Seeds | 2021 |
The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Cymenes; Humans; Hypersensitivity; Immune System Diseases; Immunologic Factors; Nigella sativa; Oleanolic Acid; Phytotherapy; Plant Extracts; Respiratory Tract Diseases; Saponins; Thymol | 2021 |
Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Bupleurum; Cell Differentiation; Humans; Neoplasms; Oleanolic Acid; Saponins | 2021 |
Bridging the Gaps between Plant and Human Health: A Systematic Review of Soyasaponins.
Topics: Biological Availability; Fabaceae; Glycine max; Humans; Oleanolic Acid; Saponins | 2021 |
Saponin constituents of Achyranthes root.
Topics: Achyranthes; Chromatography, High Pressure Liquid; Oleanolic Acid; Plant Roots; Saponins | 2022 |
Present and Future Prospects of the Anti-cancer Activities of Saikosaponins.
Topics: Drugs, Chinese Herbal; Humans; Neoplasms; Oleanolic Acid; Saponins | 2022 |
Pharmacological properties and derivatives of saikosaponins-a review of recent studies.
Topics: Anti-Inflammatory Agents; Antiviral Agents; COVID-19; Humans; Oleanolic Acid; Saponins; SARS-CoV-2 | 2023 |
Gypsogenin Battling for a Front Position in the Pentacyclic Triterpenes
Topics: Humans; Neoplasms; Oleanolic Acid; Pentacyclic Triterpenes; Prospective Studies; Saponins; Triterpenes | 2023 |
2 trial(s) available for oleanolic acid and beta-escin
| Article | Year |
|---|---|
Soyasaponin I and sapongenol B have limited absorption by Caco-2 intestinal cells and limited bioavailability in women.
Topics: Administration, Oral; Adult; Biological Availability; Caco-2 Cells; Female; Humans; Intestinal Absorption; Oleanolic Acid; Saponins | 2004 |
Saikosaponin A protects chickens against pullorum disease via modulation of cholesterol.
Topics: Animals; Anticholesteremic Agents; Bupleurum; Chickens; Cholesterol; Oleanolic Acid; Poultry Diseases; Protective Agents; Random Allocation; Salmonella enterica; Salmonella Infections, Animal; Saponins | 2019 |
1250 other study(ies) available for oleanolic acid and beta-escin
| Article | Year |
|---|---|
Long-term toxicity study of quillaia extract in mice.
Topics: Animals; Body Weight; Female; Food Additives; Male; Mice; Neoplasms, Experimental; Oleanolic Acid; Organ Size; Plant Extracts; Plants, Edible; Saponins; Time Factors; Triterpenes | 1979 |
Structure of a new saponin: chrysantellin A from Chrysanthellum procumbens Rich.
Topics: Carbohydrates; Chemical Phenomena; Chemistry; Oleanolic Acid; Plants; Saponins | 1979 |
[Isolation of 3-O-D-glucopyranosyl oleanolic acid 28-O-D-xylo-pyranoside from Eryngium bromeliifolium Delar. 29. Constituents of some Saniculoideae].
Topics: Chemical Phenomena; Chemistry; Oleanolic Acid; Plants; Saponins; Triterpenes | 1978 |
Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Female; Isoflavones; Lung Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Plants, Medicinal; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
[The identification and determination of marker substances in xiaoyao wan by three dimensional HPLC].
Topics: Benzoates; Bridged-Ring Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucosides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Monoterpenes; Oleanolic Acid; Sapogenins; Saponins | 1992 |
Clematoside-S, a triterpenoid saponin from the roots of Clematis grata.
Topics: Carbohydrate Sequence; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Triterpenes | 1990 |
Four triterpenoid saponins from dried roots of Gypsophila species.
Topics: Carbohydrate Sequence; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Terpenes | 1991 |
Triterpenoid glycosides from the bark of Mimosa tenuiflora.
Topics: Carbohydrate Sequence; Hydrolysis; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins | 1991 |
A saponin from callus tissue of Stauntonia hexaphylla.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins | 1991 |
Saponins from Deutzia corymbosa.
Topics: Carbohydrate Sequence; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins | 1991 |
Triterpenoid saponins from Medicago hispida.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Triterpenes | 1991 |
Triterpene saponins from Verbascum songaricum.
Topics: Carbohydrate Sequence; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Sugar Alcohols; Triterpenes | 1991 |
A triterpenoid and its saponin from Phytolacca esculenta.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 1991 |
A bidesmosidic oleanolic acid saponin from Panax pseudo-ginseng.
Topics: Acetylation; Carbohydrate Sequence; Ginsenosides; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Panax; Plants, Medicinal; Saponins | 1992 |
Triterpenoid saponins from Clinopodium polycephalum.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes; X-Ray Diffraction | 1992 |
A gamma-pyronyl-triterpenoid saponin from Pisum sativum.
Topics: Carbohydrate Sequence; Fabaceae; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins | 1992 |
A triterpenoid saponin from Phytolacca esculenta.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Saponins | 1992 |
Ciwujianosides D1 and C1: powerful inhibitors of histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells.
Topics: Animals; Antibodies, Anti-Idiotypic; Cells, Cultured; Histamine Release; Immunoglobulin E; Male; Mast Cells; Oleanolic Acid; Peritoneal Cavity; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Saponins | 1992 |
[Studies on the triterpenoid saponin of Cinopodium chinense (Benth) O. Kuntze].
Topics: Drugs, Chinese Herbal; Molecular Conformation; Oleanolic Acid; Saponins; X-Ray Diffraction | 1992 |
[A histochemical study of saikosaponins].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drugs, Chinese Herbal; Histocytochemistry; Immunosuppressive Agents; Oleanolic Acid; Sapogenins; Saponins | 1992 |
[Studies on the chemical constituents from Aralia elata].
Topics: Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Saponins | 1992 |
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Inactivation, Metabolic; Male; Mice; Microsomes, Liver; Oleanolic Acid; Saponins | 1992 |
Protective effects of fulvotomentosides on cadmium-induced hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Liver; Male; Metallothionein; Mice; Oleanolic Acid; Saponins; Tissue Distribution | 1992 |
[Thin layer chromatography and extractive technology of Panax japonicum C.A. Mey. var. major (Burk.) C. Y. Wu et K. M. Feng growing in Qingba Mountain Area].
Topics: Alkynes; Chromatography, Thin Layer; Drugs, Chinese Herbal; Enediynes; Fatty Alcohols; Ginsenosides; Oleanolic Acid; Panax; Plants, Medicinal; Saponins; Technology, Pharmaceutical; Triterpenes | 1992 |
A new triterpenoidal saponin from Acacia auriculiformis.
Topics: Acacia; Carbohydrate Sequence; Colorimetry; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins | 1992 |
Melandrioside A, a saponin from Melandrium firmum.
Topics: Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Plants, Medicinal; Saponins | 1992 |
Studies on the constituents of Aster scaber Thunb. III. Structures of scaberosides B7, B8 and B9, minor oleanolic acid glycosides isolated from the root.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Glycosides; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Saponins | 1992 |
Inactivation of measles virus and herpes simplex virus by saikosaponin d.
Topics: Animals; Antiviral Agents; Carbohydrate Sequence; Cell Division; Measles virus; Molecular Sequence Data; Oleanolic Acid; Sapogenins; Saponins; Vero Cells; Virus Replication | 1992 |
A new triterpenoid saponin from Ardisia crenata.
Topics: Carbohydrate Sequence; Carbohydrates; Glycoside Hydrolases; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Triterpenes | 1992 |
Two new saponins from the roots of Phytolacca esculenta.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Molecular Sequence Data; Oleanolic Acid; Saponins; Triterpenes | 1992 |
Effects of saikosaponin-d on the functions and morphology of macrophages.
Topics: Animals; Cell Movement; Cytoskeleton; Injections, Intramuscular; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Morphogenesis; Oleanolic Acid; Peritoneal Lavage; Phagocytosis; Sapogenins; Saponins | 1991 |
Effect of saikosaponin on the immune responses in mice.
Topics: Animals; Cell Division; Hemolytic Plaque Technique; Immunity; Injections, Intramuscular; Interleukin-1; Lymphocyte Activation; Lysosomes; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Peritoneal Lavage; Phagocytosis; Sapogenins; Saponins; Spleen | 1991 |
[The structure of glyeurysaponin].
Topics: Glycyrrhiza; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 1991 |
Evaluation of root quality of Bupleurum species by TLC scanner and the liver protective effects of "xiao-chai-hu-tang" prepared using three different Bupleurum species.
Topics: Animals; Calibration; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Thin Layer; Drugs, Chinese Herbal; Liver; Liver Diseases; Male; Oleanolic Acid; Plant Extracts; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1991 |
[Dynamic variation of saikosaponin contents].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Immunosuppressive Agents; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins; Spectrophotometry, Ultraviolet; Time Factors | 1991 |
The effects of saikosaponin on macrophage functions and lymphocyte proliferation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cells, Cultured; Chemotaxis, Leukocyte; Immunosuppressive Agents; Lymphocytes; Macrophages; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Phagocytosis; Plants; Sapogenins; Saponins | 1991 |
[Inhibitory effect of esculentoside A on platelet activating factor released from calcimycin induced rat peritoneal macrophages].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Macrophages; Male; Oleanolic Acid; Peritoneal Cavity; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Saponins | 1991 |
[Minor components in food plants--II. Triterpenoid saponins from Ullucus tuberosus].
Topics: Ginsenosides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oleanolic Acid; Peru; Saponins; Vegetables | 1991 |
The effects of saikosaponin-d on yeast phagocytosis and degradation in peritoneal macrophages: related increase in Fc receptor expression and altered cytoplasmic organization.
Topics: Acid Phosphatase; Animals; Cytoplasm; Macrophages; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Oleanolic Acid; Peritoneal Cavity; Phagocytosis; Receptors, Fc; Sapogenins; Saponins; Yeasts | 1991 |
Structures of two new fibrinolytic saponins from the seed of Luffa cylindrica Roem.
Topics: Fibrinolytic Agents; Humans; In Vitro Techniques; Oleanolic Acid; Saponins; Seeds | 1991 |
Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catechin; Cattle; Cells, Cultured; Endothelium, Vascular; Flavonoids; Humans; Hydrogen Peroxide; Oleanolic Acid; Platelet Aggregation; Platelet Aggregation Inhibitors; Sapogenins; Saponins; Thromboxane B2 | 1991 |
[The structure of trijuganone C from Salvia trijuga].
Topics: Drugs, Chinese Herbal; Oleanolic Acid; Phenanthrenes; Platelet Aggregation Inhibitors; Saponins | 1991 |
[Studies on antinephritic effects of plant components in rats (1). Effects of saikosaponins original-type anti-GBM nephritis in rats and its mechanisms].
Topics: Animals; Cholesterol; Corticosterone; Free Radical Scavengers; Glomerulonephritis; Glutathione Peroxidase; Kidney; Male; Oleanolic Acid; Platelet Aggregation; Platelet Aggregation Inhibitors; Proteinuria; Rats; Rats, Inbred Strains; Sapogenins; Saponins; Superoxide Dismutase | 1991 |
Periandradulcins A, B and C: phosphodiesterase inhibitors from Periandra dulcis Mart.
Topics: Carbohydrate Sequence; Fabaceae; Molecular Sequence Data; Oleanolic Acid; Phosphodiesterase Inhibitors; Plants, Medicinal; Saponins | 1991 |
[The antifungal action of polygalacic acid glycosides].
Topics: Antifungal Agents; Candida; Cryptococcus neoformans; Fungi; Glycosides; Microbial Sensitivity Tests; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 1990 |
A distinct characteristic of the quiescent state of human dermal fibroblasts in contracted collagen gel as revealed by no response to epidermal growth factor alone, but a positive growth response to a combination of the growth factor and saikosaponin b1.
Topics: Adult; Cell Division; Cells, Cultured; Collagen; Contact Inhibition; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Female; Fibroblasts; Gels; Humans; Infant, Newborn; Male; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins; Signal Transduction; Skin | 1990 |
[Isolation and identification of three new saponins from Phytolacca esculenta].
Topics: Drugs, Chinese Herbal; Oleanolic Acid; Saponins | 1990 |
Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice.
Topics: Animals; Injections, Intraperitoneal; Listeriosis; Mice; Oleanolic Acid; Pseudomonas Infections; Sapogenins; Saponins | 1990 |
[Studies on the saponin constituents of Kalopanax septemlobus (Thunb.) koidz].
Topics: Chemical Phenomena; Chemistry; Drugs, Chinese Herbal; Oleanolic Acid; Saponins | 1990 |
Simultaneous determination of ginsenosides and saikosaponins by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Ginsenosides; Glycyrrhiza; Immunosuppressive Agents; Oleanolic Acid; Panax; Plants; Plants, Medicinal; Sapogenins; Saponins | 1990 |
Esculentoside L and K: two new saponins from Phytolacca esculenta.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Saponins | 1990 |
A new active saponin from Phytolacca esculenta.
Topics: Drugs, Chinese Herbal; Interferons; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Saponins; Tumor Necrosis Factor-alpha | 1989 |
Corticosterone secretion-inducing activity of saikosaponin metabolites formed in the alimentary tract.
Topics: Animals; Biotransformation; Corticosterone; Digestive System; Male; Mice; Oleanolic Acid; Sapogenins; Saponins; Stimulation, Chemical | 1989 |
Comparison of the effects of two gypsogenin saponins towards plant and animal cells in vitro.
Topics: Animals; Cell Survival; Cells, Cultured; Liver; Oleanolic Acid; Plants; Saponins | 1989 |
[Determination of saikosaponins in radix Bupleuri using HPLC].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Sapogenins; Saponins; Species Specificity | 1989 |
Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane.
Topics: Adsorption; Erythrocyte Membrane; Hemolysis; Humans; In Vitro Techniques; Oleanolic Acid; Sapogenins; Saponins | 1989 |
[Advances in research on the chemistry of saponins in Bupleurum].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Immunosuppressive Agents; Molecular Conformation; Oleanolic Acid; Sapogenins; Saponins | 1989 |
Activation of murine peritoneal macrophages by saikosaponin a, saikosaponin d and saikogenin d.
Topics: Animals; Female; Histocompatibility Antigens Class II; Injections, Intraperitoneal; Lysosomes; Macrophage Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins | 1989 |
[Studies on the chemical constituents of Lonicera fulvotomentosa Hsu et S.C. Cheng].
Topics: Chemical Phenomena; Chemistry; Drugs, Chinese Herbal; Oleanolic Acid; Saponins | 1989 |
Effects of saikosaponin-d on enhanced CCl4-hepatotoxicity by phenobarbitone.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride Poisoning; Drug Synergism; Enzyme Induction; Lipid Peroxides; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oleanolic Acid; Phenobarbital; Rats; Rats, Inbred Strains; Sapogenins; Saponins; Time Factors | 1985 |
Effects of saikosaponins on liver tyrosine aminotransferase activity induced by cortisone in adrenalectomized rats.
Topics: Adrenalectomy; Animals; Cortisone; Enzyme Induction; Liver; Male; Oleanolic Acid; Rats; Rats, Inbred Strains; Sapogenins; Saponins; Tyrosine Transaminase | 1985 |
[Comparison on saikosaponin levels in the root of Bupleurum chinense of various sizes].
Topics: Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins; Time Factors | 1985 |
[Variation of saponins for Bupleurm scorzonerifolium and B. chinese in the extraction process and their effect on hemolysis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Hemolysis; Hot Temperature; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1985 |
An investigation of the immune suppression induced by some saikosaponin derivatives.
Topics: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; Drugs, Chinese Herbal; Female; Immunization, Passive; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Oleanolic Acid; Sapogenins; Saponins; Spleen; T-Lymphocytes, Regulatory | 1988 |
[Spectrophotometric determination of oleanolic acid and saponins from quinoa (Chenopodium quinoa Willd, Kancolla variety)].
Topics: Chromatography, Gas; Chromatography, Thin Layer; Edible Grain; Food Handling; Oleanolic Acid; Sapogenins; Saponins; Spectrophotometry | 1988 |
[Comparative studies on the roots of wild and cultured Bupleurum chinense DC].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drugs, Chinese Herbal; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1988 |
The effect of three types of saponin on iron and zinc absorption from a single meal in the rat.
Topics: Absorption; Animals; Dietary Carbohydrates; Iron; Male; Medicago sativa; Oleanolic Acid; Rats; Rats, Inbred Strains; Saponins; Zinc | 1988 |
Ardisiacrispin A and B, two utero-contracting saponins from Ardisia crispa.
Topics: Animals; Female; In Vitro Techniques; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Rats; Saponins; Triterpenes; Uterine Contraction | 1987 |
[Studies on the paridiformoside].
Topics: Animals; Chemical Phenomena; Chemistry; Drugs, Chinese Herbal; Female; Mice; Oleanolic Acid; Saponins; Stimulation, Chemical; Uterine Contraction | 1987 |
Effect of chronic treatment with saikosaponin d and dexamethasone on responsiveness of pituitary and adrenal cortex and adrenal weight in rats.
Topics: Adrenal Cortex; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Male; Oleanolic Acid; Organ Size; Pituitary Gland; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1987 |
Studies of the combined use of steroid and Shosaikoto, one of the Kampohozai (Chinese traditional medicine), on pituitary adrenocortical axis function and immune responses.
Topics: Adrenal Glands; Animals; Body Weight; Corticosterone; Drugs, Chinese Herbal; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hemagglutinins; Hemolytic Plaque Technique; Immunity; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Organ Size; Pituitary-Adrenal System; Plant Extracts; Plants, Medicinal; Prednisolone; Rats; Rats, Inbred Strains; Rosette Formation; Sapogenins; Saponins; Spleen | 1986 |
[Anti-ulcer action of chikusetsusaponin III].
Topics: Animals; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains; Saponins; Stomach Ulcer; Triterpenes | 1987 |
Purification of saikosaponins a, c and d. Application of large-scale reversed high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Japan; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1987 |
Cussonosides A and B, two triterpene-saponins from Cussonia barteri.
Topics: Animals; Hydrolysis; Molluscacides; Nigeria; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins; Triterpenes | 1986 |
Chronic effect of saikosaponin on adrenal and thymus growth in normal and dexamethasone-treated rats.
Topics: Adrenal Glands; Animals; Body Weight; Dexamethasone; Male; Oleanolic Acid; Organ Size; Rats; Rats, Inbred Strains; Sapogenins; Saponins; Thymus Gland | 1986 |
Pharmacological effects of oral saikosaponin a may differ depending on conditions of the gastrointestinal tract.
Topics: Animals; Intestinal Absorption; Liver; Male; Oleanolic Acid; Protein Biosynthesis; Rats; Sapogenins; Saponins | 1986 |
Effect of saikosaponin derivatives upon the immune response against T-dependent and T-independent antigens in mice.
Topics: Animals; Antibody-Producing Cells; Antigens, T-Independent; Erythrocytes; Female; Hemolytic Plaque Technique; Immunity; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Sapogenins; Saponins; Sheep; T-Lymphocytes | 1985 |
Pharmacological influence of saikosaponins on prostaglandin E2 production by peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; In Vitro Techniques; Macrophages; Male; Mice; Muscle Contraction; Muscle, Smooth; Oleanolic Acid; Prostaglandins E; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1985 |
Effects of saikosaponin-d on aminonucleoside nephrosis in rats.
Topics: Animals; Blood Proteins; Cholesterol; Female; Kidney; Microscopy, Electron, Scanning; Nephrosis; Oleanolic Acid; Proteinuria; Puromycin; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1986 |
Interaction of saponin of bupleuri radix with ginseng saponin: solubilization of saikosaponin-a with chikusetsusaponin V (= ginsenoside-Ro).
Topics: Animals; Chemical Phenomena; Chemistry; Ginsenosides; Hemolysis; In Vitro Techniques; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins; Sheep | 1985 |
Structural transformation of saikosaponins by gastric juice and intestinal flora.
Topics: Animals; Bacteria; Biotransformation; Chromatography, High Pressure Liquid; Fasting; Feces; Gastric Acid; In Vitro Techniques; Intestines; Kinetics; Mice; Oleanolic Acid; Rats; Sapogenins; Saponins | 1985 |
[Anti-inflammatory effect of saikosaponins (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Cell Migration Inhibition; Edema; Granuloma; Histamine Release; Oleanolic Acid; Rats; Sapogenins; Saponins | 1981 |
[Research on the pharmacology of Bupleurum chinensis].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Mice; Oleanolic Acid; Plants, Medicinal; Rats; Sapogenins; Saponins | 1983 |
[Comparison of the quality of cultivated and wild Bupleurum chinensis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins | 1983 |
The anti-allergic inflammation action of Saikosaponins.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Female; Hypersensitivity; Hypersensitivity, Delayed; Male; Mice; Oleanolic Acid; Passive Cutaneous Anaphylaxis; Rats; Sapogenins; Saponins | 1983 |
Effects of saikosaponins on the metabolic actions of adrenaline, ACTH and insulin on the fat cells.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Epinephrine; In Vitro Techniques; Insulin; Male; Oleanolic Acid; Rats; Sapogenins; Saponins | 1980 |
[Determination of saikosaponins in Chinese medicinal extracts containing Bupleuri radix].
Topics: Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins | 1984 |
[Studies on the active principles of the Chinese drug "shanglu" (Phytolacca esculenta Van Houtte). II. The isolation and structure of esculentoside E and F].
Topics: Chemical Phenomena; Chemistry; China; Glycosides; Oleanolic Acid; Plants, Medicinal; Saponins | 1984 |
Studies on the constituents of Xanthoceras sorbifolia Bunge. II. Major sapogenol and a prosapogenin from the fruits of Xanthoceras sorbifolia Bunge.
Topics: Hydrolysis; Oleanolic Acid; Plants, Medicinal; Saponins; X-Ray Diffraction | 1984 |
[Preventive and therapeutic actions of glycyrrhizin, glycyrrhetic acid and crude saikosides on experimental liver cirrhosis in rats].
Topics: Animals; Collagen; Fatty Liver; Female; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hepatitis; Liver Cirrhosis; Male; Oleanolic Acid; Rats; Sapogenins; Saponins | 1983 |
Quantitative analysis of the metabolites of saikosaponin a using high-performance liquid chromatography.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Male; Mice; Oleanolic Acid; Sapogenins; Saponins; Time Factors | 1984 |
Effect of saikosaponins on dexamethasone suppression of the pituitary-adrenocortical system.
Topics: Animals; Corticosterone; Dexamethasone; Male; Oleanolic Acid; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1984 |
[Characteristics of membrane activity of triterpene glycosides].
Topics: Cell Membrane; Glycosides; Holothurin; Lipid Bilayers; Liposomes; Marine Toxins; Oleanolic Acid; Saponins; Structure-Activity Relationship; Triterpenes | 1982 |
Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat.
Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Lipid Peroxides; Male; Microsomes, Liver; Necrosis; Oleanolic Acid; Organ Size; Plants, Medicinal; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1982 |
[Use of a strain of Aspergillus niger for purification of a hederagenin rhamnoglucoside from tubers of ficaria(Ficaria ranunculoides Moench)].
Topics: Aspergillus niger; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1982 |
[Pharmacological studies on a prescription containing Bupleuri Radix (IV). Effects of saikosaponin on the anti-inflammatory action of glucocorticoid].
Topics: Animals; Body Weight; Dexamethasone; Drug Combinations; Drug Therapy, Combination; Granuloma; Injections, Intramuscular; Lipids; Male; Oleanolic Acid; Organ Size; Plants, Medicinal; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1982 |
Pharmacological actions of saikosaponins isolated from Bupleurum falcatum. 1. Effects of saikosaponins on liver function.
Topics: Animals; In Vitro Techniques; Liver; Male; Microsomes, Liver; Oleanolic Acid; Plants, Medicinal; Rats; Sapogenins; Saponins | 1980 |
Erythrocyte membrane stabilization by plant saponins and sapogenins.
Topics: Animals; Erythrocyte Membrane; Erythrocytes; Hemolysis; Hot Temperature; In Vitro Techniques; Male; Oleanolic Acid; Osmolar Concentration; Rats; Sapogenins; Saponins; Structure-Activity Relationship | 1981 |
Stimulation of the pituitary-adrenocortical axis by saikosaponin of Bupleuri radix.
Topics: Animals; Male; Oleanolic Acid; Pituitary-Adrenal System; Plants, Medicinal; Rats; Sapogenins; Saponins; Stimulation, Chemical | 1981 |
Chemical structures and corticosterone secretion-inducing activities of saikosaponins.
Topics: Animals; Chemical Phenomena; Chemistry; Corticosterone; Male; Oleanolic Acid; Rats; Sapogenins; Saponins; Stimulation, Chemical | 1981 |
Effects of saikosaponins on biological membranes. 3. Ultrastructural studies on effects of saikosaponins on the cell surface.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Cells, Cultured; Mice; Oleanolic Acid; Sapogenins; Saponins; Surface Properties | 1981 |
The structure-hemolysis relationship of oleanolic acid derivatives and inhibition of the saponin-induced hemolysis with sapogenins.
Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Cholesterol; Hemolysis; Humans; In Vitro Techniques; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins; Structure-Activity Relationship | 1981 |
Anti-inflammatory activities of hederagenin and crude saponin isolated from Sapindus mukorossi Gaertn.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capillary Permeability; Edema; Female; Granuloma; Oleanolic Acid; Plants; Rats; Sapogenins; Saponins | 1980 |
Analgesic and other pharmacologic actions of saiko-saponin in repeated cold stressed (SART stressed) animals.
Topics: Acetylcholine; Analgesics; Animals; Behavior, Animal; Body Weight; Cold Temperature; Galvanic Skin Response; Male; Mice; Muscle Contraction; Oleanolic Acid; Rats; Sapogenins; Saponins; Sleep; Stress, Physiological | 1980 |
Asteryunnanosides F and G: two new triterpenoid saponins from Aster yunnanensis.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Roots; Saponins | 1995 |
A bidesmosidic hederagenin hexasaccharide from the roots of Symphytum officinale.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Oligosaccharides; Plant Roots; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1995 |
Acylated triterpene saponins from Silene jenisseensis.
Topics: Acylation; Carbohydrate Conformation; Carbohydrate Sequence; Granulocytes; Humans; Luminescent Measurements; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Triterpenes | 1995 |
Achyranthosides C and D, novel glucuronide saponins from Achyranthes fauriei root.
Topics: Chemical Phenomena; Chemistry, Physical; Glucuronates; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1995 |
A new monodesmosidic triterpenoid saponin from the seeds of Vigna unguiculata subsp. unguiculata.
Topics: Carbohydrate Sequence; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Saponins; Seeds; Spectrophotometry, Infrared; Triterpenes | 1995 |
Studies on the agronomic characteristics, yield, and saikosaponin content of two Bupleurum species in Taiwan.
Topics: Bupleurum; Drugs, Chinese Herbal; Germination; Immunosuppressive Agents; Oleanolic Acid; Plant Extracts; Plant Roots; Sapogenins; Saponins; Seeds; Time Factors | 1995 |
Hederagenin glycosides from Pometia eximia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Conformation; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1995 |
Oleanene-type triterpene glycosides from Puerariae Radix. II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Carbon Isotopes; Drugs, Chinese Herbal; Glycosides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1995 |
New triterpenoid saponins, asterbatanoside D and E, from Aster batangensis.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 1995 |
Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and DNA fragmentation of lymphocytes triggered by receptor-mediated and receptor-bypassed pathways.
Topics: Animals; Antibodies, Monoclonal; Calcimycin; Cell Division; Cells, Cultured; DNA Damage; Down-Regulation; Interleukin-2; Interleukin-4; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Oleanolic Acid; Receptors, Immunologic; Sapogenins; Saponins; Signal Transduction; Spleen; T-Lymphocytes; Thymus Gland; Up-Regulation | 1995 |
Medicagenic acid saponins from Aster batangensis.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1995 |
Patensin, a saponin from Pulsatilla patens var. multifida.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Spectrophotometry, Ultraviolet | 1995 |
Glycosyl compositions and structural characteristics of the potential immuno-adjuvant active saponins in the Quillaja saponaria Molina extract quil A.
Topics: Adjuvants, Immunologic; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Molecular Weight; Oleanolic Acid; Oxidation-Reduction; Plant Extracts; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1995 |
[Protective effect of the fulvotomentosides on paracetamol-induced hepatotoxicity in mice].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glutathione; Liver; Liver Diseases; Male; Mice; Oleanolic Acid; Saponins | 1995 |
[Triterpene glycosides from Hedera taurica. XIII. Structure of taurosides St-I1 and St-I2 from Crimean ivy stems].
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plant Stems; Saponins | 1995 |
Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Antagonism; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Liver Diseases; Male; Methylation; Mice; Microsomes, Liver; Oleanolic Acid; Saponins | 1995 |
Anti-growth effects with components of Sho-saiko-to (TJ-9) on cultured human hepatoma cells.
Topics: alpha-Fetoproteins; Antineoplastic Agents; Astringents; Carcinoma, Hepatocellular; Cell Cycle; Cell Death; Cell Division; DNA, Neoplasm; Drugs, Chinese Herbal; Flavanones; Flavonoids; Ginsenosides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Liver Neoplasms; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins; Tumor Cells, Cultured | 1993 |
An activator of calcium-dependent potassium channels isolated from a medicinal herb.
Topics: Animals; Calcium; Cattle; Charybdotoxin; In Vitro Techniques; Ion Channel Gating; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle, Smooth; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Potassium Channels; Saponins; Scorpion Venoms; Structure-Activity Relationship; Triterpenes | 1993 |
Functional role of the beta subunit of high conductance calcium-activated potassium channels.
Topics: Animals; Calcium; Female; Ion Channel Gating; Macromolecular Substances; Membrane Potentials; Muscle, Smooth; Oleanolic Acid; Oocytes; Patch-Clamp Techniques; Potassium Channels; RNA, Complementary; Saline Solution, Hypertonic; Saponins; Triterpenes; Xenopus laevis | 1995 |
Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Sequence; Female; Malawi; Mice; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1995 |
Structure elucidation of a glycoside of 2 beta, 3 beta, 23-trihydroxy-16-oxoolean-12-en-28-oic acid from Bellis bernardii using mass spectrometry for the sugar sequence determination.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Glycosides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins | 1995 |
Symphytoxide A, a triterpenoid saponin from the roots of Symphytum officinale.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carbohydrate Sequence; Female; Magnetic Resonance Spectroscopy; Male; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Wistar; Saponins | 1993 |
Two triterpenoid saponins from Pterocephalus bretschneidri.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 1993 |
Macrophyllicin, a saponin from Primula macrophylla.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Triterpenes | 1993 |
Clemontanoside-C, a saponin from Clematis montana.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Triterpenes | 1993 |
Clinoposaponins VI and VIII, two oleanane-triterpene saponins from Clinopodium micranthum.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Triterpenes | 1993 |
Squarroside A, a biologically active triterpene saponin from Acanthophyllum squarrosum.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Humans; Lymphocytes; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins; Triterpenes | 1993 |
An oleanolic acid based bisglycoside from Clematis montana roots.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins | 1993 |
Saponins from leaves of Acanthopanax sieboldianus.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 1993 |
Triterpenoid glycosides from Stauntonia hexaphylla.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Glycosides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1993 |
Triterpenoid saponins from Anemone hupehensis.
Topics: Carbohydrate Sequence; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Triterpenes | 1993 |
Terpenoid glycosides from the roots of Aster tataricus.
Topics: Bridged Bicyclo Compounds; Carbohydrate Sequence; Drugs, Chinese Herbal; Glucosides; Glycosides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Saponins; Terpenes | 1994 |
Acylated saponins, masonosides A-C, from the corms of Crocosmia masoniorum.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins | 1994 |
Songarosaponin D--a triterpenoid saponin from Verbascum songaricum.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins; Triterpenes | 1994 |
Oleanolic acid saponins from root bark of Aralia elata.
Topics: Carbohydrate Sequence; Japan; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins | 1994 |
Oleanolic acid saponins from root-bark of Aralia elata.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins | 1994 |
Saponins conjugated with 2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one from Phaseolus coccineus.
Topics: Carbohydrate Sequence; Fabaceae; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins | 1994 |
Oleanane-triterpene saponins from Clinopodium chinense var. parviflorum.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1994 |
An acidic triterpene glycoside from Cephalaria transsylvanica.
Topics: Carbohydrate Sequence; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Glycosides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Spectroscopy, Fourier Transform Infrared; Triterpenes | 1994 |
Triterpenoid saponins from Ardisia crenata.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Plant Roots; Plants, Medicinal; Saponins; Triterpenes | 1994 |
Anti-inflammatory triterpene saponins of Pithecellobium dulce: characterization of an echinocystic acid bisdesmoside.
Topics: Anti-Inflammatory Agents; Carbohydrate Sequence; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins; Seeds; Triterpenes | 1994 |
A saponin conjugated with 2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one from Dolichos lablab.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Superoxide Dismutase | 1995 |
Triterpenoid saponins from Clematis chinensis.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Oligosaccharides; Plant Roots; Plants, Medicinal; Saponins; Triterpenes | 1995 |
Molluscicidal saponins from Catunaregam nilotica.
Topics: Animals; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molluscacides; Oleanolic Acid; Saponins; Trees | 1995 |
Saikosaponin A-induced cell death of a human hepatoma cell line (HuH-7): the significance of the 'sub-G1 peak' in a DNA histogram.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; DNA, Neoplasm; Electrophoresis, Agar Gel; Flow Cytometry; Humans; Liver Neoplasms; Mitochondrial Swelling; Necrosis; Oleanolic Acid; Sapogenins; Saponins; Tumor Cells, Cultured | 1995 |
[Chemical constituents of Aralia decaisneana Hance].
Topics: Drugs, Chinese Herbal; Oleanolic Acid; Saponins; Sitosterols | 1994 |
Characterization of the immunoregulatory action of saikosaponin-d.
Topics: Adjuvants, Immunologic; Animals; Blotting, Northern; Cell Division; Fluorescent Antibody Technique; Genes, fos; Glycyrrhetinic Acid; Glycyrrhizic Acid; Immunosuppressive Agents; Interleukin-2; Mice; Mice, Inbred C57BL; Oleanolic Acid; Phosphorylation; Receptors, Interleukin-2; Sapogenins; Saponins; Signal Transduction; Spleen; T-Lymphocytes; Tyrosine; Up-Regulation | 1994 |
Cephalaria saponin A, a new bidesmosidic triterpene saponin from Cephalaria transsylvanica.
Topics: Carbohydrate Sequence; Chromatography, Thin Layer; Hydrolysis; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Turkey | 1994 |
[Inhibitory effects of esculentoside A on mouse macrophages and antibody production].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Hemolysin Proteins; Interleukin-1; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Oleanolic Acid; Phagocytosis; Saponins | 1994 |
High-performance capillary electrophoresis for characterization of hapten-protein conjugates used for production of antibodies against soyasaponin I.
Topics: Animals; Antibody Formation; Capillary Action; Electrophoresis; Haptens; Immunization; Micelles; Nitrophenylgalactosides; Oleanolic Acid; Pisum sativum; Rabbits; Saponins; Serum Albumin, Bovine; Trypsin Inhibitor, Kunitz Soybean | 1994 |
[Studies on the chemical components from leaves of Luffa cylinderica Roem].
Topics: Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 1993 |
[Studies on the saponin constituents of jiu jielong (Ardisea pusilla)].
Topics: Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Saponins | 1993 |
Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages.
Topics: Animals; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Oleanolic Acid; Saponins; Time Factors; Tumor Necrosis Factor-alpha | 1993 |
[Studies on the sapogenins and prosapogenins in Ardisia pusilla A. DC].
Topics: Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Oleanolic Acid; Saponins; Triterpenes | 1993 |
Comparison between the effects of crude saikosaponin and 16, 16-dimethyl prostaglandin E2 on tannic acid-induced gastric mucosal damage in rats.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diffusion; Electrolytes; Gastric Acid; Gastric Mucosa; Hydrolyzable Tannins; Male; Oleanolic Acid; Permeability; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins; Stomach Ulcer; Vagotomy | 1993 |
Elatoside E, a new hypoglycemic principle from the root cortex of Aralia elata Seem.: structure-related hypoglycemic activity of oleanolic acid glycosides.
Topics: Animals; Glycosides; Hypoglycemic Agents; Oleanolic Acid; Plants, Medicinal; Rats; Saponins; Structure-Activity Relationship | 1994 |
Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro.
Topics: 3T3 Cells; Animals; Antineoplastic Agents, Phytogenic; Carbohydrate Sequence; Mice; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins; Tumor Cells, Cultured | 1994 |
[Studies on the chemical constituents of Lonicera macranthoides Hand. -Mazz].
Topics: Drugs, Chinese Herbal; Oleanolic Acid; Saponins; Triterpenes | 1993 |
Saponin and sapogenol. L. On the constituents of the roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical structures of licorice-saponin L3 and isoliquiritin apioside.
Topics: Chalcone; China; Glycyrrhiza; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 1993 |
[Isolation and identification of two new saponins from Bupleurum smithii Wolff].
Topics: Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins | 1993 |
[Antioxidative action of soyasaponin monomers I, A1, A2, and their inhibitory effects on action potential and beating of myocardiocytes in culture].
Topics: Action Potentials; Animals; Antioxidants; Calcium Channel Blockers; Cells, Cultured; Free Radicals; Myocardium; Oleanolic Acid; Rats; Rats, Wistar; Saponins; Xanthine Oxidase; Xanthines | 1993 |
Macrophyllicinin, a saponin from Primula macrophylla.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Pakistan; Plants, Medicinal; Saponins | 1993 |
Characterization of three new triterpenoid saponins from Ardisia japonica.
Topics: Magnetic Resonance Spectroscopy; Mass Spectrometry; Medicine, Chinese Traditional; Molecular Conformation; Oleanolic Acid; Optical Rotation; Plant Extracts; Plants, Medicinal; Saponins; Triterpenes | 1993 |
Scrophulasaponins II-IV, new saikosaponin homologs from Scrophularia kakudensis FRANCH.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Sapogenins; Saponins | 1993 |
Triterpene glycosides from the roots of Dipsacus asper.
Topics: Carbohydrate Sequence; Hydrolysis; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1993 |
Induction of metallothionein by alpha-hederin.
Topics: Alanine Transaminase; Animals; Binding Sites; Blotting, Northern; Cadmium; Cadmium Chloride; Chlorides; Cytosol; Dose-Response Relationship, Drug; L-Iditol 2-Dehydrogenase; Liver; Male; Metallothionein; Mice; Microsomes, Liver; Mitochondria, Liver; Oleanolic Acid; RNA, Messenger; Saponins; Tissue Distribution | 1993 |
Effects of saiboku-to (TJ-96) on the production of platelet-activating factor in human neutrophils.
Topics: Drugs, Chinese Herbal; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Immunosuppressive Agents; Medicine, Kampo; Neutrophils; Oleanolic Acid; Platelet Activating Factor; Sapogenins; Saponins | 1993 |
Gycomoside I: a new dammarane saponin from Gynostemma compressum.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Saponins | 1993 |
Clinoposaponins I-V, new oleanane-triterpene saponins from Clinopodium gracile O. Kuntze.
Topics: Carbohydrate Sequence; Molecular Sequence Data; Oleanolic Acid; Saponins; Triterpenes | 1993 |
Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem. (Araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride Poisoning; Cell Survival; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Wistar; Saponins | 1993 |
A new triterpene glycoside from the roots of Symphytum officinale.
Topics: Carbohydrate Sequence; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Monosaccharides; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1993 |
[Quantitative analysis of deacylgymnemic acid by high-performance liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Saponins; Triterpenes | 1993 |
Optimization of hapten-protein conjugation by high-performance capillary electrophoresis.
Topics: Electrophoresis, Capillary; Haptens; Kinetics; Nitrophenylgalactosides; Oleanolic Acid; Oxidation-Reduction; Periodic Acid; Saponins; Trypsin Inhibitor, Kunitz Soybean | 1995 |
[Production of medicinal plants by soilless culture system. I. Studies of morphological characteristics and saikosaponins content in Bupleurum falcatum cultivated by Ebb & Flood system].
Topics: Botany; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sapogenins; Saponins | 1995 |
Linderniosides A and B, oleanane saponins from Lindernia pyxidaria.
Topics: Antifungal Agents; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Plants; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1995 |
Central administration of saikosaponin-d increases corticotropin-releasing factor mRNA levels in the rat hypothalamus.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Corticotropin-Releasing Hormone; Hypothalamus; Injections, Intraventricular; Male; Oleanolic Acid; Pituitary Gland, Anterior; Pro-Opiomelanocortin; Rats; Rats, Wistar; RNA, Messenger; Sapogenins; Saponins | 1995 |
Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats.
Topics: Analysis of Variance; Animals; Cadmium; Cadmium Chloride; Carcinogens; Catalase; Chlorides; Cytochrome P-450 Enzyme System; Cytochromes b5; Cytosol; Dihydrolipoamide Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Lipopolysaccharides; Liver; Male; Metallothionein; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Selenium; Superoxide Dismutase; Testosterone; Zinc Compounds | 1995 |
Medicinal foodstuffs. I. Hypoglycemic constituents from a garnish foodstuff "taranome," the young shoot of Aralia elata SEEM.: elatosides G, H, I, J, and K.
Topics: Analysis of Variance; Animals; Chemical Fractionation; Chromatography, High Pressure Liquid; Glucose Tolerance Test; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Male; Oleanolic Acid; Rats; Rats, Wistar; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship | 1995 |
Bioactive saponins and glycosides. I. Senegae radix. (1): E-senegasaponins a and b and Z-senegasaponins a and b, their inhibitory effect on alcohol absorption and hypoglycemic activity.
Topics: Animals; Blood Glucose; Chemical Phenomena; Chemistry, Physical; Ethanol; Hypoglycemic Agents; Intestinal Absorption; Male; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Stereoisomerism; Structure-Activity Relationship | 1995 |
Antitumor agents, 162. Cell-based assays for identifying novel DNA topoisomerase inhibitors: studies on the constituents of Fatsia japonica.
Topics: Antineoplastic Agents, Phytogenic; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Hydrolysis; KB Cells; Oleanolic Acid; Plant Leaves; Saponins; Topoisomerase II Inhibitors | 1995 |
Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line; Cell Nucleus; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; Kinetics; Melanoma, Experimental; Mice; Oleanolic Acid; Protein Kinase C; Sapogenins; Saponins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Effects of nine active ingredients in Chinese herbal medicine sho-saiko-to on 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide mutagenicity.
Topics: Animals; Antimutagenic Agents; Biotransformation; DNA Repair; Drugs, Chinese Herbal; Flavanones; Flavonoids; Furylfuramide; Ginsenosides; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Sapogenins; Saponins | 1995 |
Protective effects of alpha-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes.
Topics: Adult; Antimutagenic Agents; Ascorbic Acid; Cells, Cultured; Chlorophyllides; Doxorubicin; Humans; Lymphocytes; Micronucleus Tests; Oleanolic Acid; Saponins; Time Factors | 1996 |
Triterpenoid saponins from Gypsophila oldhamiana.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1995 |
[Chemical constituents of Hemsleya pengxianensis W.J. Chang].
Topics: Drugs, Chinese Herbal; Oleanolic Acid; Saponins; Triterpenes | 1995 |
Saponins from Mussaenda pubescens.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Optical Rotation; Saponins; Triterpenes | 1996 |
Leonticins A-C, three octasaccharide saponins from Leontice kiangnanensis.
Topics: Anti-Inflammatory Agents; Carbohydrate Sequence; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Oligosaccharides; Plant Extracts; Plants, Medicinal; Polysaccharides; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Steroids | 1996 |
Effect of processing on saponin content and composition of chickpeas.
Topics: Carbohydrate Sequence; Cooking; Fabaceae; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins; Time Factors | 1996 |
Bioactive saponins and glycosides. VI. Elatosides A and B, potent inhibitors of ethanol absorption, from the bark of Aralia elata SEEM. (Araliaceae): the structure-requirement in oleanolic acid glucuronide-saponins for the inhibitory activity.
Topics: Animals; Carbohydrate Sequence; Central Nervous System Depressants; Chemical Phenomena; Chemistry, Physical; Depression, Chemical; Ethanol; Intestinal Absorption; Magnetic Resonance Spectroscopy; Male; Molecular Sequence Data; Oleanolic Acid; Plant Epidermis; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Structure-Activity Relationship | 1996 |
Bioactive saponins and glycosides. VII. On the hypoglycemic principles from the root cortex of Aralia elata Seem.: structure related hypoglycemic activity of oleanolic acid oligoglycoside.
Topics: Animals; Carbohydrate Sequence; Chemical Phenomena; Chemistry, Physical; Depression, Chemical; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Male; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Structure-Activity Relationship | 1996 |
Oleanene-type triterpene glycosides from puerariae radix. III. Three new saponins from Pueraria thomsonii.
Topics: Chromatography, Thin Layer; Fabaceae; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 1996 |
Triterpenoid saponins from Bellis bernardii.
Topics: Carbohydrate Sequence; France; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins | 1996 |
Can soyasaponin I and mono- and bi-desmosides isolated from mungbeans serve as growth enhancers in mungbeans and lettuce?
Topics: Chromatography, Thin Layer; Fabaceae; Lactuca; Molecular Structure; Oleanolic Acid; Plant Leaves; Plant Roots; Plants, Medicinal; Saponins | 1996 |
Structural determination of saponins from mungbean sprouts by tandem mass spectrometry.
Topics: Carbohydrate Sequence; Fabaceae; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Saponins from alfalfa, clover, and mungbeans analyzed by electrospray ionization-mass spectrometry as compared with positive and negative FAB-mass spectrometry.
Topics: Fabaceae; Mass Spectrometry; Medicago sativa; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Seeds; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Two new saponins, congmuyenosides A and B, from the leaves of Aralia elata collected in Heilongjiang, China.
Topics: Carbohydrate Sequence; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Sequence Data; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Phyto-pharmacology of saponins from Symphytum officinale L.
Topics: Animals; Carbohydrate Sequence; Europe; Hemodynamics; Magnetic Resonance Spectroscopy; Male; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1996 |
Antinociceptive mechanisms of dipsacus saponin C administered intracerebroventricularly in the mouse.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Carbohydrate Sequence; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oleanolic Acid; Pain Measurement; Reaction Time; Receptors, Cholecystokinin; Receptors, N-Methyl-D-Aspartate; Saponins; Serotonin Receptor Agonists | 1996 |
An echinocystic acid saponin derivative from Kalimeris shimadae.
Topics: Hydrolysis; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Triterpenoid saponins from Herniaria fontanesii.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 1996 |
Structure elucidation of three triterpene glycosides from the trunk of Argania spinosa.
Topics: Carbohydrate Sequence; Molecular Sequence Data; Morocco; Oleanolic Acid; Saponins; Trees | 1996 |
A new triterpenoid saponin, bredemeyeroside B. from the roots of Bredemeyera floribunda.
Topics: Antivenins; Brazil; Carbohydrate Sequence; Crotalid Venoms; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 1996 |
Triterpenoid saponins from Aster lingulatus.
Topics: Antineoplastic Agents, Phytogenic; Carbohydrate Conformation; Carbohydrate Sequence; DNA Replication; HL-60 Cells; Humans; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plant Extracts; Plants; Saponins; Thymidine; Triterpenes | 1997 |
Novel saponins hainaneosides A and B isolated from Marsdenia hainanensis.
Topics: Abortifacient Agents, Nonsteroidal; Animals; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plants; Rats; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1997 |
Triterpenoid saponins from Mimusops elengi.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; India; Magnetic Resonance Spectroscopy; Medicine, Traditional; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins; Seeds; Spectrometry, Mass, Fast Atom Bombardment; Spectrometry, Mass, Secondary Ion; Spectroscopy, Fourier Transform Infrared; Trees; Triterpenes | 1997 |
Triterpene saponins from Cyclamen mirabile and their biological activities.
Topics: Acetylcholine; Animals; Anti-Bacterial Agents; Bacteria; Female; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oleanolic Acid; Plant Roots; Plants, Medicinal; Rats; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes; Uterine Contraction | 1997 |
Oleanene-type triterpene glycosides from puerariae radix. IV. Six new saponins from Pueraria lobata.
Topics: Carbohydrate Sequence; Chromatography, Thin Layer; Glycosides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Triterpenes | 1997 |
Triterpenoid saponins from Aster bellidiastrum.
Topics: Carbohydrate Sequence; Chromatography, Thin Layer; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins | 1997 |
Inhibitory activity of soyasaponin II on virus replication in vitro.
Topics: Animals; Antiviral Agents; Cell Line; Herpesvirus 1, Human; Humans; Oleanolic Acid; Saponins; Virion; Virus Replication | 1997 |
Medicinal foodstuffs. VI. 1) Histamine release inhibitors from kidney bean, the seeds of Phaseolus vulgaris L.: chemical structures of sandosaponins A and B.
Topics: Animals; Carbohydrate Sequence; Exudates and Transudates; Fabaceae; Histamine Antagonists; Histamine Release; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Molecular Sequence Data; Oleanolic Acid; Peritoneal Cavity; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Seeds | 1997 |
Suppressive effects of sairei-to on monoclonal antibody 1-22-3-induced glomerulonephritis: analysis of effective components.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Blood Chemical Analysis; Drugs, Chinese Herbal; Female; Glomerulonephritis; Kidney; Oleanolic Acid; Proteinuria; Rats; Rats, Wistar; Sapogenins; Saponins | 1997 |
Isolation and structure elucidation of a highly haemolytic saponin from the Merck saponin extract using high-field gradient-enhanced NMR techniques.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Oligosaccharides; Saponins | 1997 |
Asterlingulatosides C and D, cytotoxic triterpenoid saponins from Aster lingulatus.
Topics: Antineoplastic Agents, Phytogenic; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship | 1997 |
Jennisseensosides C and D, biologically active acylated triterpene saponins from Silene jenisseensis.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Drugs, Chinese Herbal; Humans; Lymphocyte Activation; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Phagocytosis; Saponins; T-Lymphocytes; Triterpenes | 1997 |
Molecular constituents of maxi KCa channels in human coronary smooth muscle: predominant alpha + beta subunit complexes.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Agents, Phytogenic; Calcium; Child; Coronary Vessels; Electric Stimulation; Female; Humans; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channel beta Subunits; Large-Conductance Calcium-Activated Potassium Channels; Male; Middle Aged; Molecular Sequence Data; Muscle, Smooth, Vascular; Oleanolic Acid; Oocytes; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated; Saponins; Triterpenes; Xenopus laevis | 1997 |
Medicinal foodstuffs. VII. On the saponin constituents with glucose and alcohol absorption-inhibitory activity from a food garnish "Tonburi", the fruit of Japanese Kochia scoparia (L.) Schrad.: structures of scoparianosides A, B, and C.
Topics: Animals; Central Nervous System Depressants; Chemical Phenomena; Chemistry, Physical; Chenopodiaceae; Ethanol; Fruit; Glucose; Hydrolysis; Hypoglycemic Agents; Japan; Magnetic Resonance Spectroscopy; Male; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Structure-Activity Relationship | 1997 |
Saikosaponin homologues from Clinopodium spp. The structures of clinoposaponins XII-XX.
Topics: Carbohydrate Conformation; Magnetic Resonance Spectroscopy; Oleanolic Acid; Sapogenins; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1997 |
Saniculoside N from Sanicula europaea L.
Topics: Anti-HIV Agents; HIV-1; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Reverse Transcriptase Inhibitors; Saponins; Triterpenes | 1997 |
Triterpenoid saponin from Vaccaria segetalis.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins | 1998 |
Saikosaponin homologues from Verbascum spp. The structures of mulleinsaponins I-VII.
Topics: Carbohydrate Sequence; Carbohydrates; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Sapogenins; Saponins; Terminology as Topic | 1997 |
The elucidation of the structure of thalicoside F, A. minor oleanane glycoside from Thalictrum minus L.
Topics: Carbohydrate Sequence; Glycosides; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Saponins; Siberia; Triterpenes | 1998 |
Oleanane saponins from Polyscias fruticosa.
Topics: Carbohydrate Sequence; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Extracts; Plant Leaves; Plant Roots; Plants, Medicinal; Saponins | 1998 |
Polygalasaponins XLII-XLVI from roots of Polygala glomerata.
Topics: Carbohydrate Sequence; Molecular Conformation; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins | 1998 |
Enzymes responsible for the metabolism of saikosaponins from Eubacterium sp. A-44, a human intestinal anaerobe.
Topics: alpha-L-Fucosidase; Anti-Inflammatory Agents, Non-Steroidal; Culture Media; Eubacterium; Feces; Glucosidases; Humans; Hydrogen-Ion Concentration; Intestines; Molecular Weight; Oleanolic Acid; Sapogenins; Saponins; Substrate Specificity | 1997 |
Repeated administration of alpha-hederin results in alterations in maternal zinc status and adverse developmental outcome in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Embryonic and Fetal Development; Female; Maternal-Fetal Exchange; Metallothionein; Oleanolic Acid; Pregnancy; Pregnancy Outcome; Rats; Rats, Sprague-Dawley; Saponins; Zinc; Zinc Radioisotopes | 1997 |
Kaikasaponin III and soyasaponin I, major triterpene saponins of Abrus cantoniensis, act on GOT and GPT: influence on transaminase elevation of rat liver cells concomitantly exposed to CCl4 for one hour.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbohydrate Sequence; Carbon Tetrachloride; Liver; Male; Medicine, Chinese Traditional; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Wistar; Saponins | 1998 |
Saniculoside R-1: a new triterpenoid saponin from Sanicula europaea.
Topics: Carbohydrate Sequence; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins | 1998 |
Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cardiac Glycosides; Catecholamines; Cattle; Central Nervous System Agents; Chromaffin Cells; Dose-Response Relationship, Drug; Ginsenosides; Glycyrrhizic Acid; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins | 1998 |
Triterpenoid saponins from Spergularia ramosa.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Peru; Plant Extracts; Plants, Medicinal; Saponins; Triterpenes | 1998 |
A new oleanene glucuronide having a branched-chain sugar from Melilotus officinalis.
Topics: Antiviral Agents; Fabaceae; Glucuronates; Oleanolic Acid; Plants, Medicinal; Saponins | 1998 |
QS-21 and QS-7: purified saponin adjuvants.
Topics: Adjuvants, Immunologic; Animals; Chromatography, High Pressure Liquid; Female; HIV Envelope Protein gp120; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Chemical; Oleanolic Acid; Ovalbumin; Quillaja; Recombinant Proteins; Saponins; T-Lymphocytes, Cytotoxic | 1998 |
Esculentoside A inhibits tumor necrosis factor, interleukin-1, and interleukin-6 production induced by lipopolysaccharide in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Interleukin-1; Interleukin-6; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Regression Analysis; Saponins; Shock, Septic; Thymus Gland; Tumor Necrosis Factor-alpha | 1998 |
Metabolism of kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites.
Topics: Animals; Blood Glucose; Chemical Phenomena; Chemistry, Physical; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Intestinal Mucosa; Intestines; Lipids; Magnetic Resonance Spectroscopy; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 1998 |
Pentacyclic triterpenoid saponin from Cyclamen coum.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1998 |
Medicinal foodstuffs. XII. Saponin constituents with adjuvant activity from hyacinth bean, the seeds of Dolichos lablab L. (1): Structures of lablabosides A, B, and C.
Topics: Adjuvants, Immunologic; Carbohydrate Sequence; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins; Seeds; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1998 |
Triterpenoid saponins from Quillaja saponaria.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trees | 1998 |
The prevention of carbon tetrachloride-induced hepatotoxicity in mice by alpha-hederin: inhibiton of cytochrome P450 2E1 expression.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drugs, Chinese Herbal; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oleanolic Acid; Saponins | 1998 |
Triterpenoid saponins and sapogenins from Vaccaria segetalis.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins; Spectrum Analysis; Triterpenes | 1998 |
Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and Eubacterium sp. A-44-infected gnotobiote rats.
Topics: Animals; Anti-Allergic Agents; Antineoplastic Agents, Phytogenic; Eubacterium; Feces; Gastrointestinal Contents; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Oleanolic Acid; Permeability; Rats; Rats, Wistar; Sapogenins; Saponins | 1998 |
A triterpenoid saponin from Cyclamen coum.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Oligosaccharides; Plant Extracts; Plant Roots; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1998 |
Saponins from Gliricidia sepium.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Fabaceae; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Optical Rotation; Plant Extracts; Plants, Medicinal; Saponins | 1998 |
Triterpenoidal saponins from Baptisia australis.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Fabaceae; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1998 |
ELISA for the determination of saikosaponin a, an active component of Bupleuri Radix.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Specificity; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Oleanolic Acid; Ovalbumin; Plants, Medicinal; Rabbits; Sapogenins; Saponins | 1998 |
Mechanism of maxi-K channel activation by dehydrosoyasaponin-I.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aorta; Calcium; Cattle; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Ion Channel Gating; Kinetics; Membrane Potentials; Oleanolic Acid; Potassium Channels; Saponins; Sarcolemma; Triterpenes | 1998 |
In vivo and in vitro antiinflammatory activity of saikosaponins.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Sequence; Cell Survival; Cells, Cultured; Dinoprostone; Ear, External; Edema; Female; Humans; Leukotriene C4; Macrophages, Peritoneal; Male; Mice; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins; Tetradecanoylphorbol Acetate | 1998 |
[The structure activity relationship of saikosaponins and glycyrrhizin derivatives for Na+, K(+)-ATPase inhibiting action].
Topics: Cell-Free System; Glycyrrhizic Acid; Humans; Oleanolic Acid; Sapogenins; Saponins; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship | 1996 |
Structures of three new oleanene glucuronides isolated from Lathyrus palustris var. pilosus and hepatoprotective activity.
Topics: Animals; Cells, Cultured; Immune Sera; Japan; Liver; Medicine, Traditional; Oleanolic Acid; Plants, Medicinal; Rats; Saponins; Structure-Activity Relationship; Triterpenes | 1998 |
[Chemical constituents of the roots of Bupleurum longicaule Wall. ex DC. var. franchetii de Boiss and B. chaishoui Shan et Sheh].
Topics: Apiaceae; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sapogenins; Saponins | 1996 |
Effect of alpha-hederin and sapindoside B on hepatic microsomal cytochrome P-450 in mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Male; Mice; Microsomes, Liver; Oleanolic Acid; Phenobarbital; Saponins | 1996 |
Suppression of constitutive and inducible cytochrome P450 gene expression by alpha-hederin in mice.
Topics: Aniline Hydroxylase; Animals; Blotting, Northern; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gene Expression Regulation; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oleanolic Acid; Oxidoreductases; Phenobarbital; Protein Isoforms; Pyridines; Saponins; Time Factors | 1998 |
Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi.
Topics: Antifungal Agents; Arthrodermataceae; Candida albicans; Cryptococcus neoformans; Fungi; Humans; Microbial Sensitivity Tests; Oleanolic Acid; Saponins | 1998 |
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Size; Fluorescent Antibody Technique; Melanins; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Neoplasm Transplantation; Oleanolic Acid; Sapogenins; Saponins; Tumor Cells, Cultured | 1998 |
Production of antibody against saikosaponin a, an active component of bupleuri radix.
Topics: Animals; Antibodies; Carbohydrate Sequence; Cattle; Culture Media; Haptens; Immunosuppressive Agents; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins; Serum Albumin, Bovine | 1998 |
Structures of new acylated oleanene-type triterpene oligoglycosides, theasaponins E1 and E2, from the seeds of tea plant, Camellia sinensis (L.) O. Kuntze.
Topics: Acylation; Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Seeds; Spectrometry, Mass, Fast Atom Bombardment; Tea | 1998 |
Noroleanane saponins from Celmisia spectabilis.
Topics: Carbohydrate Conformation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oleanolic Acid; Plants; Saponins | 1998 |
Saikosaponins from roots of Bupleurum scorzonerifolium.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Conformation; Carbohydrate Sequence; China; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sapogenins; Saponins | 1999 |
Study of the action of alpha-hederin on the ultrastructure of Candida albicans.
Topics: Antifungal Agents; Candida albicans; Microscopy, Electron; Oleanolic Acid; Saponins | 1998 |
A new biologically active acylated triterpene saponin from Silene fortunei.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Granulocytes; Lymphocyte Activation; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Phagocytosis; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; T-Lymphocytes; Triterpenes | 1999 |
Effect of alpha-hederin on hepatic detoxifying systems in mice.
Topics: Animals; Antioxidants; Catalase; Copper; Drugs, Chinese Herbal; Glutathione; Liver; Male; Metallothionein; Mice; Oleanolic Acid; Saponins; Zinc | 1997 |
Saponarioside C, the first alpha-D-galactose containing triterpenoid saponin, and five related compounds from Saponaria officinalis.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1999 |
Saponins from the stem bark of Kalopanax pictum var. magnificum (I).
Topics: Carbohydrate Sequence; Hydrolysis; Korea; Molecular Sequence Data; Oleanolic Acid; Plant Epidermis; Plant Extracts; Plant Stems; Plants, Medicinal; Saponins; Trees | 1991 |
Triterpenoidal saponins from the bark of Kalopanax pictum var. typicum.
Topics: Carbohydrate Sequence; Hydrolysis; Korea; Molecular Sequence Data; Oleanolic Acid; Plant Epidermis; Plants, Medicinal; Saponins; Trees; Triterpenes | 1991 |
[Effects of new constituents L-6a and L-10 from leaves of Luffa cylinderica on learning, memory, and hippocampal somatostatin in rats].
Topics: Animals; Avoidance Learning; Cucurbitaceae; Female; Hippocampus; Male; Oleanolic Acid; Rats; Rats, Wistar; Retention, Psychology; Saponins; Somatostatin | 1997 |
Silenosides A-C, triterpenoid saponins from Silene vulgaris.
Topics: Carbohydrate Sequence; Europe; Magnetic Resonance Spectroscopy; Magnoliopsida; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Saponins | 1999 |
Suppressive effects of alpha-Hederin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated murine Cyp1a-1 expression in the mouse hepatoma Hepa-1c1c7 cells.
Topics: Animals; Cytochrome P-450 CYP1A1; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Liver Neoplasms, Experimental; Mice; Oleanolic Acid; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Saponins; Tumor Cells, Cultured | 1999 |
Biologically active triterpene saponins from callus tissue of Polygala amarella.
Topics: Adjuvants, Immunologic; Carbohydrate Sequence; Chromatography, Gas; Europe; Granulocytes; Humans; Hydrolysis; In Vitro Techniques; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Phagocytosis; Plants, Medicinal; Saponins; Seeds; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1999 |
Two new triterpenoid saponins from Platycodon grandiflorum.
Topics: Carbohydrate Sequence; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrophotometry, Infrared; Triterpenes | 1999 |
Inhibition of mouse ear edema by steroidal and triterpenoid saponins.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Croton Oil; Ear, External; Edema; Hydrocortisone; Indomethacin; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Random Allocation; Saponins; Triterpenes | 1999 |
In vitro anticomplementary activity of hederagenin saponins isolated from roots of Dipsacus asper.
Topics: Animals; Anti-Inflammatory Agents; Complement Hemolytic Activity Assay; Complement Inactivator Proteins; Hemolysis; Humans; In Vitro Techniques; Oleanolic Acid; Plant Extracts; Saponins; Sheep; Steroids | 1999 |
A saponin with anti-ulcerogenic effect from the flowers of Spartium junceum.
Topics: Animals; Anti-Ulcer Agents; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Rats; Saponins | 1999 |
A cytotoxic triterpene saponin from the root bark of Aralia dasyphylla.
Topics: Antineoplastic Agents, Phytogenic; China; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Hydrolysis; KB Cells; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Epidermis; Plant Roots; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Tumor Cells, Cultured | 1999 |
Effects of oleanolic acid glycosides on gastrointestinal transit and ileus in mice.
Topics: Animals; Capsaicin; Disease Models, Animal; Gastrointestinal Transit; Glucuronates; Glycosides; Intestinal Obstruction; Laparotomy; Male; Mice; Oleanolic Acid; Saponins; Streptozocin; Triterpenes | 1999 |
Anticomplement activities of oleanolic acid monodesmosides and bisdesmosides isolated from Tiarella polyphylla.
Topics: Complement Inactivator Proteins; Complement Pathway, Classical; Glycosides; Humans; Korea; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Saponins | 1999 |
The protective activity of alpha-hederine against H2O2 genotoxicity in HepG2 cells by alkaline comet assay.
Topics: Catalase; Cell Membrane; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Glutathione; Humans; Hydrogen Peroxide; Mutagenicity Tests; Oleanolic Acid; Oxidation-Reduction; Protective Agents; Proteins; Saponins; Tumor Cells, Cultured | 1999 |
A new major triterpene saponin from the roots of Cucurbita foetidissima.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Cucurbitaceae; Drug Screening Assays, Antitumor; Humans; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Saponins; Spectrum Analysis; Tumor Cells, Cultured | 2000 |
Cytotoxicity of triterpenoid saponins. Part 2: Relationships between the structures of glycosides of polygalacic acid and their activities against pathogenic Candida species.
Topics: Antineoplastic Agents, Phytogenic; Candida albicans; Glycosides; Hydrolysis; Microbial Sensitivity Tests; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 2000 |
A new oleanene glucuronide obtained from the aerial parts of Melilotus officinalis.
Topics: Carbohydrate Sequence; Chromatography, Thin Layer; Molecular Sequence Data; Oleanolic Acid; Plant Leaves; Plant Stems; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 2000 |
[Isolation and structure elucidation of cirensenosides Q and R].
Topics: Magnoliopsida; Molecular Structure; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Saponins; Triterpenes | 1997 |
Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Drug Antagonism; Flavanones; Flavonoids; Glioma; Oleanolic Acid; Prostaglandin Antagonists; Rats; Sapogenins; Saponins; Tumor Cells, Cultured | 1999 |
Characterization and antimutagenic activity of soybean saponins.
Topics: Animals; Antimutagenic Agents; Carcinogens; Chemical Fractionation; CHO Cells; Cricetinae; Fluorenes; Glycine max; Molasses; Molecular Structure; Mutagenicity Tests; Mutagens; Oleanolic Acid; Plant Extracts; Pyrones; Quinolines; Saponins | 2000 |
Momordin I, a compound of ampelopsis radix, inhibits AP-1 activation induced by phorbol ester.
Topics: 3T3 Cells; Animals; Binding, Competitive; Cell Division; Cell Survival; Mice; Oleanolic Acid; Plants; Proto-Oncogene Proteins c-jun; RNA, Messenger; Saponins; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2000 |
Molluscicidal saponins from Anagallis arvensis against schistosome intermediate hosts.
Topics: Animals; Biomphalaria; Magnetic Resonance Spectroscopy; Models, Chemical; Mollusca; Molluscacides; Niclosamide; Oleanolic Acid; Plants, Medicinal; Saponins; Schistosoma; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 2000 |
Separation and structural analysis of some saponins from Quillaja saponaria Molina.
Topics: Carbohydrate Sequence; Chromatography, Gas; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Rosales; Sapogenins; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2000 |
Triterpenoid saponins containing an acetylated branched D-fucosyl residue from Quillaja saponaria Molina.
Topics: Acetylation; Carbohydrate Sequence; Fucose; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trees; Triterpenes | 2000 |
Triterpene saponins from the fruits of Hedera helix.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacillus cereus; Candida albicans; Escherichia coli; Fruit; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oleanolic Acid; Plants; Saponins; Spectrophotometry, Infrared; Staphylococcus epidermidis; Triterpenes | 2000 |
Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro.
Topics: Animals; Antiprotozoal Agents; Cell Division; Cell Line; Humans; Leishmania infantum; Oleanolic Acid; Saponins | 2000 |
High-performance liquid chromatographic analysis of saponin compounds in Bupleurum falcatum.
Topics: Chromatography, High Pressure Liquid; Magnoliopsida; Oleanolic Acid; Plant Roots; Quality Control; Reproducibility of Results; Sapogenins; Saponins | 2000 |
Antinociceptive mechanisms of dipsacus saponin C administered intrathecally in mice.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; China; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Pain Measurement; Plants, Medicinal; Receptors, Adrenergic, alpha-2; Receptors, Cholecystokinin; Receptors, GABA; Receptors, Serotonin; Saponins; Serotonin Antagonists | 2000 |
Anti-herpes virus activity of fabaceous triterpenoidal saponins').
Topics: Animals; Antiviral Agents; Cell Survival; Chlorocebus aethiops; Herpesvirus 1, Human; Microbial Sensitivity Tests; Oleanolic Acid; Rosales; Saponins; Structure-Activity Relationship; Triterpenes; Vero Cells | 2000 |
Sileneoside H, a new phytoecdysteroid from Silene brahuica.
Topics: Molecular Structure; Oleanolic Acid; Plants; Saponins; Spectrum Analysis | 2000 |
Rivalosides A and B, two 19-Oxo triterpenoid saponins from Galium rivale.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Oleanolic Acid; Rubiaceae; Saponins; Spectrum Analysis | 2000 |
Characterization of some O-acetylated saponins from Quillaja saponaria Molina.
Topics: Acetylation; Chromatography, Affinity; Magnetic Resonance Spectroscopy; Methylation; Monosaccharides; Oleanolic Acid; Oligosaccharides; Sapogenins; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trees | 2000 |
Hepatoprotective and hepatotoxic activities of sophoradiol analogs on rat primary liver cell cultures.
Topics: Animals; Cells, Cultured; Glucuronides; Hepatocytes; Male; Oleanolic Acid; Rats; Rats, Wistar; Saponins; Structure-Activity Relationship; Triterpenes | 2000 |
Triterpenoid saponins from Ardisia mamillata.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Sequence Data; Oleanolic Acid; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triterpenes | 2000 |
[Liver-protective activity of Aralia taibaiensis Z.Z. Wang et H.C. Zheng].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; Magnoliopsida; Male; Mice; Oleanolic Acid; Saponins | 1997 |
Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Hypoglycemic Agents; Hypolipidemic Agents; Isoflavones; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin | 2000 |
Two new biologically active triterpene saponins from Acanthophyllum squarrosum.
Topics: Adjuvants, Immunologic; Carbohydrate Sequence; Cell Division; Hydrolysis; Lymphocytes; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Plant Roots; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared | 2000 |
Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bcl-2 mRNA.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Cell Survival; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Lymphocyte Count; Lymphocytes; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sapogenins; Saponins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androgen Receptor Antagonists; Androstadienes; Animals; Antineoplastic Agents, Hormonal; Cell Division; Chlorocebus aethiops; Finasteride; Growth Inhibitors; Humans; Ketoconazole; Male; Mice; Mice, Nude; Mice, SCID; Neoplasms, Hormone-Dependent; Oleanolic Acid; Pregnadienes; Prostatic Neoplasms; Receptors, Androgen; Saponins; Steroid 17-alpha-Hydroxylase; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2000 |
Novel acetylated triterpenoid saponins in a chromatographic fraction from Quillaja saponaria Molina.
Topics: Acetylation; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Fucose; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Rosales; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Terpenes | 2000 |
Structural studies of triterpenoid saponins with new acyl components from Quillaja saponaria Molina.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Rosales; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triterpenes | 2000 |
Kinmoonosides A-C, three new cytotoxic saponins from the fruits of Acacia concinna, a medicinal plant collected in myanmar.
Topics: Antineoplastic Agents, Phytogenic; Carbohydrate Conformation; Carbohydrate Sequence; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Rosales; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Tumor Cells, Cultured | 2000 |
Determination of binding constant of transcription factor AP-1 and DNA. Application of inhibitors.
Topics: Cloning, Molecular; Cyclooxygenase Inhibitors; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutathione; Glutathione Transferase; Inhibitory Concentration 50; Kinetics; Masoprocol; Models, Biological; Oleanolic Acid; Plasmids; Protein Binding; Proto-Oncogene Proteins c-fos; Recombinant Fusion Proteins; Saponins; Sepharose; Sodium Chloride; Thermodynamics; Time Factors; Transcription Factor AP-1 | 2001 |
Bioactive oleanolic acid saponins and other constituents from the roots of Viguiera decurrens.
Topics: Asteraceae; Drug Screening Assays, Antitumor; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Tumor Cells, Cultured | 2001 |
Triterpenoid saponins from Vaccaria segetalis.
Topics: Carbohydrate Sequence; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plants, Medicinal; Saponins; Seeds; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 1999 |
Three new triterpenoid saponins from the seeds of Vaccaria segetalis.
Topics: China; Chromatography; Drugs, Chinese Herbal; Humans; Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Structure; Oleanolic Acid; Saponins; Seeds; Triterpenes | 2000 |
Extraction, isolation and characterisation of antitumor principle, alpha-hederin, from the seeds of Nigella sativa.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Drug Screening Assays, Antitumor; Magnoliopsida; Mice; Molecular Structure; Oleanolic Acid; Saponins; Seeds; Tumor Cells, Cultured | 2001 |
Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Glycosides; Humans; Male; Mice; Mice, Inbred Strains; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Toxicology of Kalopanax pictus extract and hematological effect of the isolated anti-rheumatoidal kalopanaxsaponin A on the Freunds complete adjuvant reagent-treated rat.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Blood Cell Count; Body Weight; Cholesterol; Drugs, Chinese Herbal; Freund's Adjuvant; Indicators and Reagents; L-Lactate Dehydrogenase; Lethal Dose 50; Liver Function Tests; Mice; Mice, Inbred ICR; Oleanolic Acid; Organ Size; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Saponins; Triglycerides | 2001 |
Four new oleanane saponins from Anemone anhuiensis.
Topics: China; Glucosides; Hydrolysis; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 2001 |
Studies on the constituents of Clematis species. VIII. Triterpenoid saponins from the aerial part of Clematis tibetana KUNTZ.
Topics: Carbohydrate Sequence; Chromatography, Liquid; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nepal; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Saponins; Spectrophotometry, Ultraviolet; Triterpenes | 2001 |
Soyasaponin I, a potent and specific sialyltransferase inhibitor.
Topics: Animals; beta-Galactoside alpha-2,3-Sialyltransferase; Binding, Competitive; Brain; COS Cells; Cytidine Monophosphate N-Acetylneuraminic Acid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Fucosyltransferases; Galactosyltransferases; Mice; Oleanolic Acid; Saponins; Sialyltransferases; Substrate Specificity | 2001 |
In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B.
Topics: Animals; Antiprotozoal Agents; Leishmania mexicana; Magnoliopsida; Oleanolic Acid; Parasitic Sensitivity Tests; Plants, Medicinal; Saponins | 2001 |
Saikosaponin v-1 from roots of Bupleurum chinense DC.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Bupleurum; China; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sapogenins; Saponins; Triterpenes | 2001 |
Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Liver Neoplasms; Oleanolic Acid; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sapogenins; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Drugs, Chinese Herbal; Enzyme Induction; Indomethacin; Isoenzymes; Macrophages, Peritoneal; Membrane Proteins; Oleanolic Acid; Plant Roots; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Saponins; Tetradecanoylphorbol Acetate; Triterpenes | 2001 |
Three new acylated triterpene saponins from Acanthophyllum squarrosum.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plant Roots; Plants; Saponins; Terpenes; Triterpenes | 2001 |
[Advances in the study of anti-inflammatory and immunoregulatory effects of saikosaponins and their similar substances].
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drugs, Chinese Herbal; Oleanolic Acid; Sapogenins; Saponins | 1998 |
Eclalbatin, a triterpene saponin from Eclipta alba.
Topics: Asteraceae; Chromatography, Thin Layer; India; Mass Spectrometry; Medicine, Traditional; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Saponins; Spectrophotometry, Infrared; Triterpenes; Ursolic Acid | 2001 |
Two unusual oleanane saponins from Anemone anhuiensis.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Plant Structures; Saponins; Triterpenes | 2001 |
Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice.
Topics: Amino Acid Sequence; Blotting, Northern; Blotting, Southern; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Glycyrrhiza; Glycyrrhizic Acid; Intramolecular Transferases; Molecular Sequence Data; Oleanolic Acid; RNA, Messenger; Saccharomyces cerevisiae; Saponins | 2001 |
Purification of saponin compounds in Bupleurum falcatum by solvent partitioning and preparative LC.
Topics: Bupleurum; Chromatography, Liquid; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins; Solvents | 2001 |
A new triterpenoidal saponin from Ixeris sonchifolia and its cytotoxic activity.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes; Tumor Cells, Cultured | 2001 |
Acetylated triterpene saponins from the Thai medicinal plant, Sapindus emarginatus.
Topics: Acetylation; Animals; Chromatography, High Pressure Liquid; Intestinal Absorption; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Rats; Sapindaceae; Saponins; Solubility; Spectrometry, Mass, Fast Atom Bombardment; Thailand; Triterpenes | 2001 |
[Studies on the chemical structure of lucyoside R from leaves of Luffa cylindrica roem].
Topics: Luffa; Molecular Structure; Oleanolic Acid; Saponins | 1997 |
[Saponins in Bupleurum smithii Wolff var. parvifolium Shan et Y. Li].
Topics: Bupleurum; Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1998 |
[Oleanolic acid saponins from the root bark of Aralia taibaiensis].
Topics: Aralia; Drugs, Chinese Herbal; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 1997 |
[Determination of oleanolic acid and total saponins in Aralia L].
Topics: Aralia; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Plant Stems; Plants, Medicinal; Saponins; Species Specificity | 1998 |
Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka.
Topics: Carbohydrate Sequence; Centella; Hydrolysis; Molecular Sequence Data; Oleanolic Acid; Oligosaccharides; Plant Extracts; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Sri Lanka; Triterpenes | 2001 |
[Saikosaponin-d up-regulates GR mRNA expression and induces apoptosis in HL-60 cells].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; HL-60 Cells; Humans; Oleanolic Acid; Receptors, Glucocorticoid; RNA, Messenger; Sapogenins; Saponins; Up-Regulation | 1999 |
Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Antioxidants; Arthritis, Rheumatoid; Cytochrome P-450 Enzyme System; Freund's Adjuvant; Liver; Male; Oleanolic Acid; Oxidoreductases; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins | 2002 |
Inhibitory role of GDP on saikosaponin (I) stimulated enzymes secretion and rising of [Ca2+]i in rat pancreatic acini.
Topics: Animals; Calcium; Cells, Cultured; Guanosine Diphosphate; Male; Oleanolic Acid; Pancreas; Pancreatin; Rats; Saponins | 2001 |
Junceosides A-C, new triterpene saponins from Arenaria juncea.
Topics: Caryophyllaceae; Chemical Phenomena; Chemistry, Physical; Chromatography, Thin Layer; Drugs, Chinese Herbal; Hydrolysis; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Spectrophotometry, Infrared; Triterpenes | 2001 |
Superoxide- and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activities of soyasaponin beta g related to gallic acid.
Topics: Bepridil; Biphenyl Compounds; Carbohydrate Sequence; Free Radical Scavengers; Free Radicals; Gallic Acid; Molecular Sequence Data; Oleanolic Acid; Picrates; Saponins; Superoxides | 2001 |
Efficient production of saikosaponins in Bupleurum falcatum root fragments combined with signal transducers.
Topics: Acetates; Calcium Chloride; Cyclopentanes; Oleanolic Acid; Oxylipins; Plants; Sapogenins; Saponins; Signal Transduction; Structure-Activity Relationship | 2001 |
[Effect of Saikosaponin-d on up-regulating GR mRNA expression and inhibiting cell growth in human leukemia cells].
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Division; HL-60 Cells; Humans; Oleanolic Acid; Receptors, Glucocorticoid; RNA, Messenger; Sapogenins; Saponins; Up-Regulation | 2000 |
Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals.
Topics: Analgesics; Animals; Antirheumatic Agents; Araliaceae; Arthritis, Experimental; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Pain Measurement; Phytotherapy; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins | 2002 |
A new triterpene saponin from Pittosporum viridiflorum from the Madagascar rainforest.
Topics: Antineoplastic Agents, Phytogenic; Chromatography, Thin Layer; Drug Screening Assays, Antitumor; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Madagascar; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Ovarian Neoplasms; Plants, Medicinal; Saccharomyces cerevisiae; Saponins; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured | 2002 |
A new biologically active triterpenoid saponin from the leaves of Lepidagathis hyalina Nees.
Topics: Acanthaceae; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Aspartic Acid Endopeptidases; Aspergillus; Bacillus; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Escherichia coli; Fusarium; Hydrolysis; India; Klebsiella; Medicine, Ayurvedic; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Penicillium; Plant Leaves; Plants, Medicinal; Proteus; Rhizopus; Salmonella; Saponins; Spectrophotometry, Infrared; Staphylococcus; Triterpenes | 2001 |
Saponins-mediated potentiation of cisplatin accumulation and cytotoxicity in human colon cancer cells.
Topics: Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Synergism; HT29 Cells; Humans; Oleanolic Acid; Plant Extracts; Plant Roots; Platinum; Saponins; Silene; Structure-Activity Relationship; Triterpenes | 2002 |
Two new triterpenoid saponins from Aralia subcapitata.
Topics: Aralia; Medicine, Chinese Traditional; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Spectrophotometry, Infrared; Stereoisomerism; Triterpenes | 2001 |
Two major saponins from seeds of Barringtonia asiatica: putative antifeedants toward Epilachna sp. larvae.
Topics: Animals; Chromatography, High Pressure Liquid; Coleoptera; Feeding Behavior; Indonesia; Larva; Magnoliopsida; Mass Spectrometry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plants, Medicinal; Saponins; Seeds; Spectroscopy, Fourier Transform Infrared; Stereoisomerism | 2002 |
Bioactive saponins from Acacia tenuifolia from the suriname rainforest.
Topics: Acacia; Animals; Antifungal Agents; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Female; Gas Chromatography-Mass Spectrometry; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Ovarian Neoplasms; Plants, Medicinal; Saponins; Stereoisomerism; Suriname; Triterpenes; Tumor Cells, Cultured; Yeasts | 2002 |
Antiviral activity of seven iridoids, three saikosaponins and one phenylpropanoid glycoside extracted from Bupleurum rigidum and Scrophularia scorodonia.
Topics: Animals; Antiviral Agents; Bupleurum; Carbohydrate Sequence; Cell Line; Chlorocebus aethiops; Cricetinae; Dose-Response Relationship, Drug; Glucosides; HeLa Cells; Herpesvirus 1, Human; Humans; Iridoids; Medicine, Traditional; Molecular Sequence Data; Oleanolic Acid; Phenols; Plant Extracts; Poliovirus; Pyrans; Sapogenins; Saponins; Scrophulariaceae; Vero Cells; Vesicular stomatitis Indiana virus | 2002 |
Toxin clues to beetle relationships.
Topics: Adaptation, Biological; Animals; Coleoptera; Diet; Evolution, Molecular; Host-Parasite Interactions; Oleanolic Acid; Pigmentation; Saponins; Toxins, Biological; Triterpenes | 2002 |
Induction of differentiation in rat C6 glioma cells with Saikosaponins.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Antineoplastic Agents, Phytogenic; Bupleurum; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Glioma; Glutamate-Ammonia Ligase; Medicine, Chinese Traditional; Oleanolic Acid; Phosphoric Diester Hydrolases; Plant Extracts; Plant Roots; Rats; Sapogenins; Saponins; Tumor Cells, Cultured | 2002 |
[A new saikosaponin from Bupleurum Chinese DC].
Topics: Bupleurum; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins | 1998 |
[A new saikosaponin from Bupleurum chinense DC].
Topics: Bupleurum; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins; Triterpenes | 1998 |
Quantification of the group B soyasaponins by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Food Analysis; Food Handling; Glycine max; Hot Temperature; Isoflavones; Oleanolic Acid; Saponins; Soybean Proteins | 2002 |
Three new triterpene saponins from two species of Carpolobia.
Topics: Antineoplastic Agents, Phytogenic; Chromatography, Thin Layer; Cisplatin; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Hydrolysis; Molecular Structure; Nigeria; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plants, Medicinal; Polygalaceae; Saponins; Stereoisomerism; Triterpenes; Tumor Cells, Cultured | 2002 |
In vitro antiinflammatory activity of kalopanaxsaponin A isolated from Kalopanax pictus in murine macrophage RAW 264.7 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Araliaceae; Cell Line; Cell Survival; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oleanolic Acid; Plant Bark; Prostaglandin-Endoperoxide Synthases; Saponins; Tumor Necrosis Factor-alpha | 2002 |
[Determination of diterpenoic acid, triterpenoids and tritersaponins in Aralia by RP-HPLC].
Topics: Aralia; Chromatography, High Pressure Liquid; Diterpenes; Drugs, Chinese Herbal; Oleanolic Acid; Saponins; Species Specificity; Triterpenes | 1998 |
Characteristics and mechanism of enzyme secretion and increase in [Ca2+]i in Saikosaponin(I) stimulated rat pancreatic acinar cells.
Topics: Amylases; Animals; Calcium; Drugs, Chinese Herbal; In Vitro Techniques; Male; Oleanolic Acid; Pancreas; Rats; Rats, Wistar; Sapogenins; Saponins; Sincalide | 2002 |
Expression of inducible nitric oxide synthase by alpha-hederin in macrophages.
Topics: Animals; Caprifoliaceae; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Female; Gene Expression Regulation, Enzymologic; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oleanolic Acid; Polymyxin B; RNA, Messenger; Saponins | 2002 |
Effect of esculentoside A on autoimmunity in mice and its possible mechanisms.
Topics: Animals; Antibodies, Antinuclear; Apoptosis; Autoimmunity; Cell Line; Endothelium, Vascular; Humans; Inflammation; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred BALB C; Oleanolic Acid; Phytolacca; Plants, Medicinal; RNA, Messenger; Saponins; Thymus Gland; Umbilical Cord | 2002 |
Effect of saikosaponin-A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma.
Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Bupleurum; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Antagonists; Histamine Release; In Vitro Techniques; Male; Molecular Structure; Muscle, Smooth; Oleanolic Acid; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Wistar; Sapogenins; Saponins; Time Factors; Trachea | 2002 |
Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana.
Topics: Animals; Antimutagenic Agents; Antioxidants; Carbohydrate Sequence; Flowers; In Vitro Techniques; Isoflavones; Lipid Peroxidation; Liver; Male; Malondialdehyde; Molecular Sequence Data; Mutagens; Oleanolic Acid; Pueraria; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Saponins; Subcellular Fractions | 2002 |
Oleanane saponins in "kancolla", a sweet variety of Chenopodium quinoa.
Topics: Chenopodium; Chromatography, Gas; Hydrolysis; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Peru; Plants, Edible; Saponins; Seeds; Stereoisomerism; Triterpenes | 2002 |
New triterpenoids from the leaves of Abrus precatorius.
Topics: Abrus; Florida; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Saponins; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Triterpenes | 2002 |
Isolation of antifungal saponins from Phytolacca tetramera, an Argentinean species in critic risk.
Topics: Antifungal Agents; Argentina; Colony Count, Microbial; Fungi; Magnetic Resonance Spectroscopy; Methanol; Oleanolic Acid; Phytolacca; Plant Extracts; Plant Structures; Saponins; Triterpenes | 2002 |
UDP-glucuronic acid:soyasapogenol glucuronosyltransferase involved in saponin biosynthesis in germinating soybean seeds.
Topics: Carbon Radioisotopes; Cations; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Activation; Germination; Glucuronosyltransferase; Glycine max; Hydrogen-Ion Concentration; Kinetics; Magnesium; Microsomes; Oleanolic Acid; Saponins; Seeds; Solubility; Substrate Specificity; Temperature; Uridine Diphosphate Glucuronic Acid | 2002 |
Different mechanisms underlying the stimulation of K(Ca) channels by nitric oxide and carbon monoxide.
Topics: Animals; Calcium; Carbon Monoxide; COS Cells; Cytoplasm; Dose-Response Relationship, Drug; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oleanolic Acid; Oligonucleotides, Antisense; Patch-Clamp Techniques; Potassium; Potassium Channels, Calcium-Activated; Protein Binding; Rats; Rats, Sprague-Dawley; Saponins; Time Factors; Transfection; Triterpenes | 2002 |
[Studies on technology of supercritical-CO2 fluid extraction for volatile oils and saikosaponins in Bupleurum chinense DC].
Topics: Bupleurum; Carbon Dioxide; Chromatography, Supercritical Fluid; Oils, Volatile; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2000 |
[Studies on the effect-increasing components for molluscacides in nut of Areca catech L].
Topics: Animals; Areca; Arecoline; Drug Synergism; Molluscacides; Nuts; Oleanolic Acid; Pentachlorophenol; Plants, Medicinal; Saponins; Snails | 2000 |
Estrogenic and antiproliferative properties of soy sapogenols in human breast cancer cells in vitro.
Topics: Blotting, Northern; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrogens; Estrogens, Non-Steroidal; Female; Fulvestrant; Gene Expression; Glycine max; Humans; Isoflavones; Oleanolic Acid; Phytoestrogens; Plant Extracts; Plant Preparations; Receptors, Estrogen; RNA, Messenger; Saponins; Tumor Cells, Cultured | 2002 |
The effects of the total saponin of Dipsacus asperoides on the damage of cultured neurons induced by beta-amyloid protein 25-35.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Brain; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus; Hydro-Lyases; Lipid Peroxidation; Malondialdehyde; Neurons; Neuroprotective Agents; Oleanolic Acid; Oxidative Stress; Peptide Fragments; Rats; Saponins; Tetrazolium Salts; Thiazoles | 2002 |
Determination of soyasaponins in soy with LC-MS following structural unification by partial alkaline degradation.
Topics: Chromatography, High Pressure Liquid; Glycine max; Hydrogen-Ion Concentration; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization | 2002 |
Characterization of new sweet triterpene saponins from Albizia myriophylla.
Topics: Adult; Albizzia; Carbohydrate Sequence; Humans; Hydrolysis; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plants, Edible; Saponins; Structure-Activity Relationship; Sweetening Agents; Thailand; Triterpenes | 2002 |
Cycloartane and oleanane saponins from egyptian astragalus spp. as modulators of lymphocyte proliferation.
Topics: Adjuvants, Immunologic; Animals; Astragalus Plant; Dose-Response Relationship, Drug; Egypt; Humans; Lymphocytes; Magnetic Resonance Spectroscopy; Medicine, Traditional; Mice; Mice, Inbred Strains; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Saponins; Triterpenes; Tumor Cells, Cultured | 2002 |
[Chemical constituents analysis on anticonvulsive effect of three extracts from radix bupleuri].
Topics: Anticonvulsants; Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Glycerol; Linoleic Acid; Oils, Volatile; Oleanolic Acid; Plants, Medicinal; Saponins; Xylitol | 2002 |
A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula.
Topics: Acetates; Amino Acid Sequence; Carbohydrate Sequence; Cells, Cultured; Cyclopentanes; Escherichia coli; Expressed Sequence Tags; Farnesyl-Diphosphate Farnesyltransferase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Genomics; Intramolecular Transferases; Medicago; Molecular Sequence Data; Oleanolic Acid; Oxygenases; Oxylipins; Phylogeny; Phytosterols; Saponins; Signal Transduction; Squalene Monooxygenase; Triterpenes | 2002 |
Antiviral saponins from Tieghemella heckelii.
Topics: Anti-HIV Agents; CD4 Antigens; Cote d'Ivoire; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fruit; HeLa Cells; HIV; Humans; Oleanolic Acid; Plants, Medicinal; Saponins; Sapotaceae; Stereoisomerism; Tumor Cells, Cultured | 2002 |
Ethanol sensitivity of BK(Ca) channels from arterial smooth muscle does not require the presence of the beta 1-subunit.
Topics: Animals; Arteries; Calcium; Cattle; Estradiol; Ethanol; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Muscle, Smooth, Vascular; Oleanolic Acid; Oocytes; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Protein Subunits; Saponins; Xenopus laevis | 2003 |
ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.
Topics: Activating Transcription Factor 2; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Depression, Chemical; Electrophoresis, Capillary; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, p16; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Saponins; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
[Studies on the triterpenoidal saponins from flowers of Eriobotrya japonica].
Topics: Eriobotrya; Gas Chromatography-Mass Spectrometry; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes; Ursolic Acid | 2001 |
[Comparison of soyasaponin and isoflavone contents between genetically modified (GM) and non-GM soybeans].
Topics: Food, Genetically Modified; Glycine max; Isoflavones; Oleanolic Acid; Saponins | 2002 |
Two new biologically active triterpenoidal saponins acylated with salicylic acid from Albizia adianthifolia.
Topics: Acetylation; Adjuvants, Immunologic; Albizzia; Animals; Antineoplastic Agents, Phytogenic; Cote d'Ivoire; Dose-Response Relationship, Drug; Erythrocytes; Hemolysis; Humans; Jurkat Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Plants, Medicinal; Salicylic Acid; Saponins; Sheep; Triterpenes | 2003 |
Antiproliferative constituents from Umbelliferae plants VI. New ursane-type saikosaponin analogs from the fruits of Bupleurum rotundifolium.
Topics: Animals; Apiaceae; Bupleurum; Fruit; Growth Inhibitors; Humans; Mice; Oleanolic Acid; Plant Extracts; Saponins; Tumor Cells, Cultured | 2003 |
Antiinflammatory activity of alpha-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Butanols; Edema; Esters; Hydrolysis; Kalopanax; Male; Oleanolic Acid; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins | 2003 |
Relationship between adjuvant activity and amphipathic structure of soyasaponins.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Carbohydrate Sequence; Chickens; Dose-Response Relationship, Drug; Immunoglobulin G; Mice; Molecular Sequence Data; Oleanolic Acid; Ovalbumin; Saponins; Structure-Activity Relationship | 2003 |
Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells.
Topics: Animals; Apoptosis; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; Intracellular Membranes; Leukemia P388; Mice; Mitochondria; Nigella sativa; Oleanolic Acid; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Saponins; Tumor Cells, Cultured | 2003 |
Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra.
Topics: Acetates; Cells, Cultured; Cyclopentanes; Farnesyl-Diphosphate Farnesyltransferase; Glucuronosyltransferase; Glycyrrhiza; Intramolecular Transferases; Oleanolic Acid; Oxylipins; RNA, Messenger; Saponins | 2003 |
Simultaneous identification of soyasaponins and isoflavones and quantification of soyasaponin Bb in soy products, using liquid chromatography/electrospray ionization-mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Glycine max; Isoflavones; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization | 2003 |
[Studies on chemical constituents from Anemone anhuiensis Y. K. Yang N. Wang et W. C. Ye].
Topics: Anemone; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2001 |
[Determination of the content of saponin in Kochia scoparia fruits from different producing areas].
Topics: Chenopodiaceae; Ecosystem; Fruit; Oleanolic Acid; Plants, Medicinal; Quality Control; Saponins | 2002 |
Synthesis of the trisaccharide portion of soyasaponin beta g: evaluation of a new glucuronic acid acceptor.
Topics: Carbohydrate Sequence; Glucuronates; Models, Chemical; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Saponins; Trisaccharides | 2003 |
A saponin correlated with variable resistance of Barbarea vulgaris to the diamondback moth Plutella xylostella.
Topics: Adaptation, Physiological; Animals; Barbarea; Biological Assay; Feeding Behavior; Larva; Moths; Oleanolic Acid; Pest Control, Biological; Plant Leaves; Saponins; Seasons | 2003 |
Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; Genistein; Humans; Oleanolic Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Saponins; Time Factors; Tumor Cells, Cultured | 2003 |
Hepatoprotective constituents in plants. 14. Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells.
Topics: Carbohydrate Sequence; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Glucuronides; Glycyrrhizic Acid; Humans; Liver; Molecular Sequence Data; Oleanolic Acid; Saponins; tert-Butylhydroperoxide | 2003 |
Soyasapogenol A and B distribution in soybean (Glycine max L. Merr.) in relation to seed physiology, genetic variability, and growing location.
Topics: Germination; Glycine max; Isoflavones; Oleanolic Acid; Saponins; Seedlings; Seeds; Water | 2003 |
Studies on saponins. VIII. The preparation of oleanolic acid monoglucuronoside and diglucuronoside.
Topics: Oleanolic Acid; Saponins; Syzygium | 1956 |
Isolation of a saponin, hederin, and its sapogenin, hederagenin, from bur clover (Medicago hispida).
Topics: Humans; Intestines; Medicago; Oleanolic Acid; Sapogenins; Saponins; Trifolium | 1957 |
Saponins and sapogenins. IV. Isolation of oleanolic acid from Sesbania aegyptica Pers.
Topics: Oleanolic Acid; Sapogenins; Saponins; Seeds; Sesbania | 1959 |
Oleanolic glycosides from Pometia ridleyi.
Topics: Animals; Carbohydrate Conformation; Erythrocytes; Glycosides; Hemolysis; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Bark; Plant Stems; Sapindaceae; Saponins; Sheep; Spectrometry, Mass, Electrospray Ionization | 2003 |
Isolation of oleanolic acid and saponin from trefoil (Lotus corniculatus, var. viking).
Topics: Lotus; Oleanolic Acid; Plants; Saponins | 1961 |
Oleanolic acid in Lardizabala biternata.
Topics: Oleanolic Acid; Plants; Saponins | 1961 |
[On the occurrence of oleanolic acid in Boquilla trifoliolata (D.C.) Dcne].
Topics: Humans; Oleanolic Acid; Saponins | 1962 |
Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species.
Topics: Antineoplastic Agents, Phytogenic; Antiviral Agents; Blotting, Western; Bupleurum; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Primers; DNA, Viral; Hepatitis B virus; Humans; Oleanolic Acid; Phytotherapy; Plant Extracts; Polymerase Chain Reaction; Saponins | 2003 |
Recycling plant wax constituents for chemical defense: hemi-biosynthesis of triterpene saponins from beta-amyrin in a leaf beetle.
Topics: Animals; Asteraceae; Coleoptera; Oleanolic Acid; Plant Leaves; Saponins; Triterpenes; Waxes | 2003 |
[Effect of chailing decoction and its active ingredients on experimental nephritis in rats].
Topics: Animals; Antibodies, Monoclonal; Drugs, Chinese Herbal; Female; Nephritis; Oleanolic Acid; Proteinuria; Rats; Rats, Wistar; Saponins | 2003 |
Development of an assay system for saikosaponin a using anti-saikosaponin a monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Bupleurum; Carrier Proteins; Chromatography, High Pressure Liquid; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Haptens; In Situ Hybridization; Medicine, Kampo; Mice; Mice, Inbred BALB C; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
[Effect of esculentoside A on cellular adhesion].
Topics: Adult; CD18 Antigens; Cell Adhesion; Cell Line; Drugs, Chinese Herbal; Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Neutrophils; Oleanolic Acid; Phytolacca; Plants, Medicinal; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Umbilical Veins | 2003 |
A novel saponin hydrolase from Neocosmospora vasinfecta var. vasinfecta.
Topics: Amino Acid Sequence; Ascomycota; Base Sequence; Glycine max; Hydrolases; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Sequence Analysis, DNA; Trichoderma | 2004 |
Soyasaponins: the relationship between chemical structure and colon anticarcinogenic activity.
Topics: Acetylation; Anticarcinogenic Agents; Cell Division; Colonic Neoplasms; Fabaceae; Fermentation; Humans; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Patensin-induced apoptosis is accompanied by decreased bcl-2 expression and telomerase activity in HL-60 cells.
Topics: Apoptosis; Cell Division; Flow Cytometry; Fluorescent Antibody Technique; Genes, bcl-2; HL-60 Cells; Humans; Oleanolic Acid; Saponins; Telomerase | 2004 |
2070-DTI, a topoisomerase inhibitor produced by Streptomyces sp. strain No. 2070.
Topics: Animals; Camptothecin; Carbohydrate Sequence; Cattle; Cell Cycle; Chlorocebus aethiops; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Etoposide; HeLa Cells; Humans; Mice; Molecular Sequence Data; NIH 3T3 Cells; Oleanolic Acid; Saponins; Streptomyces; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Vero Cells | 2003 |
Acetylated glucuronide triterpene bidesmosidic saponins from Symplocos glomerata.
Topics: Acetylation; Animals; Apocynaceae; Carbohydrate Conformation; Carbohydrate Sequence; Erythrocytes; Hemolysis; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Bark; Plant Stems; Saponins; Sheep; Triterpenes | 2004 |
Oleanane saponins from Sanicula elata var. chinensis.
Topics: Chromatography, High Pressure Liquid; Japan; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Sanicula; Saponins; Triterpenes | 2004 |
Hydrocotylosides I-VII, new oleanane saponins from hydrocotylesibthorpioides.
Topics: Apiaceae; Hydrolysis; Japan; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Stereoisomerism; Triterpenes | 2004 |
Further saponins from Meryta lanceolata.
Topics: Araliaceae; Carbohydrate Conformation; Carbohydrate Sequence; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Plant Stems; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 2004 |
New biologically active triterpenoid saponins from Scabiosa tschiliensis.
Topics: Enzyme Inhibitors; Lipase; Medicine, Chinese Traditional; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pancreas; Plants, Medicinal; Saponins; Stereoisomerism; Triterpenes | 2004 |
Human fecal metabolism of soyasaponin I.
Topics: Adolescent; Adult; Anaerobiosis; Feces; Female; Humans; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Middle Aged; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization | 2004 |
Effect of kaikasaponin III obtained from Pueraria thunbergiana flowers on serum and hepatic lipid peroxides and tissue factor activity in the streptozotocin-induced diabetic rat.
Topics: Aldehyde Oxidase; Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Enzyme Induction; Flowers; Glutathione Peroxidase; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Peroxidation; Liver; Male; Oleanolic Acid; Oxidation-Reduction; Pueraria; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; Superoxide Dismutase; Thromboplastin; Xanthine Oxidase | 2004 |
Function and clustered expression of MaxiK channels in cerebral myocytes remain intact with aging.
Topics: Age Factors; Aging; Animals; Calcium; Cerebral Arteries; Immunohistochemistry; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscle Cells; Muscle, Smooth, Vascular; Oleanolic Acid; Peptides; Potassium Channels, Calcium-Activated; Rats; Rats, Inbred F344; Saponins; Toxins, Biological; Vasoconstriction | 2004 |
Dynamics of beta2-adrenergic receptor-ligand complexes on living cells.
Topics: Adrenergic beta-Agonists; Animals; Cell Line; Colforsin; Endocytosis; Epithelial Cells; Fluorescent Dyes; Hippocampus; Humans; Immunohistochemistry; Ligands; Molecular Structure; Neurons; Norepinephrine; Oleanolic Acid; Protein Isoforms; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Saponins; Spectrometry, Fluorescence; Terbutaline | 2004 |
Effects of esculentoside A on production of interleukin-1, 2, and prostaglandin E2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Dinoprostone; Drugs, Chinese Herbal; Female; Interferon-gamma; Interleukin-1; Interleukin-2; Lymphocytes; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Oleanolic Acid; Phytolacca; Plants, Medicinal; Saponins | 2004 |
A new adaptive subband decomposition approach for automatic analysis of NMR data.
Topics: Algorithms; Computer Simulation; Magnetic Resonance Spectroscopy; Oleanolic Acid; Reproducibility of Results; Saponins; Sensitivity and Specificity; Signal Processing, Computer-Assisted | 2004 |
The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lung Neoplasms; Medicine, Chinese Traditional; Membrane Glycoproteins; Oleanolic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reagent Kits, Diagnostic; Saponins; Tumor Suppressor Protein p53 | 2004 |
Antioxidant activity of saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F.
Topics: Antioxidants; Biphenyl Compounds; Hedera; Humans; Lipid Peroxidation; Oleanolic Acid; Phytotherapy; Picrates; Plant Extracts; Saponins | 2004 |
Determination of saikosaponin derivatives in Radix bupleuri and in pharmaceuticals of the chinese multiherb remedy xiaochaihu-tang using liquid chromatographic tandem mass spectrometry.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrometry, Mass, Electrospray Ionization | 2004 |
Synthesis and hemolytic activity of some hederagenin diglycosides.
Topics: Acetamides; Carboxylic Acids; Chloroacetates; Disaccharides; Esters; Glycosides; Glycosylation; Hemolysis; Oleanolic Acid; Saponins; Structure-Activity Relationship; Trichloroacetic Acid | 2004 |
Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Survival; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Membrane Glycoproteins; NF-kappa B; Oleanolic Acid; Proteins; Receptors, Tumor Necrosis Factor; Saponins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2004 |
Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity.
Topics: Animals; Asteraceae; Cell Line; Growth Inhibitors; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Rats; Saponins | 2004 |
Induction of apoptosis in a leukemia cell line by triterpene saponins from Albizia adianthifolia.
Topics: Albizzia; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line; Dose-Response Relationship, Drug; Hemolysis; Humans; Jurkat Cells; Oleanolic Acid; Plants, Medicinal; Saponins; T-Lymphocytes; Triterpenes; Tumor Cells, Cultured | 2004 |
Triterpene saponins from the roots of Clematis chinensis.
Topics: Antineoplastic Agents; Clematis; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; HL-60 Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Tumor Cells, Cultured | 2004 |
[Therapeutical effects of esculentoside A on rats with MsPGN induced by anti-Thy1.1 antibody].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Drugs, Chinese Herbal; Glomerular Mesangium; Glomerulonephritis, Membranoproliferative; Male; Oleanolic Acid; Phytotherapy; Rabbits; Random Allocation; Rats; Rats, Wistar; Saponins; Thy-1 Antigens | 2004 |
Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of the Ha-Ras/MEK/ERK cascade.
Topics: Cell Survival; Cholesterol; Endothelium, Vascular; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Neovascularization, Pathologic; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; ras Proteins; Saponins; Umbilical Veins | 2004 |
HPLC profiling and quantification of active principles in leaves of Hedera helix L.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Densitometry; Hedera; Oleanolic Acid; Plant Extracts; Plant Leaves; Reproducibility of Results; Saponins | 2004 |
Saikosaponin C induces endothelial cells growth, migration and capillary tube formation.
Topics: Antineoplastic Agents, Phytogenic; Capillaries; Cell Movement; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Gene Expression; Humans; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; Oleanolic Acid; RNA, Messenger; Saponins; Umbilical Veins; Vascular Endothelial Growth Factor A | 2004 |
Structure elucidation by NMR spectroscopy of a new acetylated saponin from Centratherum anthelminticum.
Topics: Asteraceae; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Seeds | 2004 |
[Effect of saikosaponins on epileptic rat electroenciphalogram].
Topics: Animals; Electroencephalography; Epilepsy; Female; Male; Oleanolic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2004 |
Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids.
Topics: beta-Galactoside alpha-2,3-Sialyltransferase; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Oleanolic Acid; Saponins; Sialic Acids; Sialyltransferases | 2005 |
Insecticidal components from field pea extracts: soyasaponins and lysolecithins.
Topics: Animals; Glycine max; Insecticides; Lysophosphatidylcholines; Oleanolic Acid; Pisum sativum; Plant Extracts; Saponins; Weevils | 2004 |
Araloside A, an antiulcer constituent from the root bark of Aralia elata.
Topics: Animals; Anti-Ulcer Agents; Aralia; Male; Oleanolic Acid; Plant Bark; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Saponins; Stomach Ulcer | 2005 |
Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained from the stem of Akebia quinata.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Butanols; Dose-Response Relationship, Drug; Hydrolysis; Magnoliopsida; Male; Methanol; Mice; Mice, Inbred ICR; Oleanolic Acid; Pain Measurement; Plant Extracts; Plant Stems; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins | 2005 |
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model.
Topics: Animals; Concanavalin A; Crystallography, X-Ray; Disease Models, Animal; Hepatitis, Animal; Liver; Liver Function Tests; Male; Mice; Mice, Inbred BALB C; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins | 2005 |
Triterpenoid saponin anthranilates from Albizia grandibracteata leaves ingested by primates in Uganda.
Topics: Albizzia; Animals; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Feeding Behavior; Humans; KB Cells; Molecular Structure; Oleanolic Acid; ortho-Aminobenzoates; Plant Leaves; Plants, Medicinal; Plasmodium falciparum; Primates; Saponins; Triterpenes; Tumor Cells, Cultured; Uganda | 2005 |
Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Calorimetry, Differential Scanning; Cell Membrane; Cholesterol Esters; Fluoresceins; Liposomes; Oleanolic Acid; Rabbits; Saponins; Spectroscopy, Fourier Transform Infrared | 2005 |
Soyasaponins lowered plasma cholesterol and increased fecal bile acids in female golden Syrian hamsters.
Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Cholesterol; Cricetinae; Feces; Female; Glycine max; Mesocricetus; Oleanolic Acid; Saponins; Sterols | 2005 |
Determination of saikosaponins a, c, and d in Bupleurum Chinese DC from different areas by capillary zone electrophoresis.
Topics: Borates; Buffers; Bupleurum; Cyclodextrins; Drugs, Chinese Herbal; Electrophoresis, Capillary; Molecular Structure; Oleanolic Acid; Powders; Reproducibility of Results; Saponins; Stereoisomerism | 2005 |
Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Edema; Hedera; Male; Oleanolic Acid; Phytotherapy; Plant Leaves; Rats; Rats, Wistar; Saponins; Structure-Activity Relationship | 2005 |
Therapeutic mechanism of Saikosaponin-d in anti-Thy1 mAb 1-22-3-induced rat model of glomerulonephritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Blood Pressure; Blotting, Western; CD8-Positive T-Lymphocytes; Collagen Type I; Disease Progression; Female; Fluorescent Antibody Technique; Gene Expression Regulation; Glomerulonephritis, Membranoproliferative; Isoantibodies; Kidney Glomerulus; Macrophages; Mesangial Cells; Oleanolic Acid; Proteinuria; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
High performance liquid chromatographic assay of saikosaponins from radix Bupleuri in China.
Topics: Bupleurum; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Indicators and Reagents; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Reference Standards; Reproducibility of Results; Saponins; Spectrophotometry, Ultraviolet | 2005 |
Involvement of cytokines in the hepatic metallothionein expression by alpha-hederin.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Interleukin-6; Macrophages; Metallothionein; Mice; Oleanolic Acid; Phytotherapy; Plants, Medicinal; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Tumor Necrosis Factor-alpha | 2005 |
[Studies on chemical constituents in the seeds of Nigella glandulifera].
Topics: Glycosides; Molecular Conformation; Molecular Structure; Nigella; Oleanolic Acid; Plants, Medicinal; Saponins; Seeds; Sitosterols | 2005 |
Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis).
Topics: Animals; Camellia sinensis; Flowers; Hypolipidemic Agents; Japan; Male; Mice; Molecular Structure; Oleanolic Acid; Olive Oil; Plant Oils; Plants, Medicinal; Saponins; Stereoisomerism; Triterpenes | 2005 |
[Cholesteryl hemisuccinate as liposomal membrane stabilizer and its use in the preparation of saikosaponin-D liposomes].
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Calorimetry, Differential Scanning; Cell Membrane; Cholesterol; Cholesterol Esters; Drug Carriers; Fluoresceins; Hemolysis; Liposomes; Oleanolic Acid; Rabbits; Saponins; Spectroscopy, Fourier Transform Infrared | 2005 |
[Chemical constituents from rhizome of Pulsatilla dahurica].
Topics: Oleanolic Acid; Plants, Medicinal; Pulsatilla; Rhizome; Saponins; Sitosterols | 2005 |
Cytotoxic saponins from the root of Dipsacus asper Wall.
Topics: Animals; Antineoplastic Agents, Phytogenic; HL-60 Cells; Humans; Leukemia L1210; Mice; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Structure-Activity Relationship | 2005 |
[Inhibitory effect of ardipusilloside-I on Lewis pulmonary carcinoma and hepatocarcinoma SMMC-7721].
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Oleanolic Acid; Plants, Medicinal; Saponins | 2005 |
Saikosaponin-d inhibits T cell activation through the modulation of PKCtheta, JNK, and NF-kappaB transcription factor.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; I-kappa B Proteins; Interleukin-2; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lectins, C-Type; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Oleanolic Acid; Phosphorylation; Protein Kinase C; Protein Kinase C-theta; Receptors, Transferrin; Saponins; T-Lymphocytes | 2005 |
Synthesis of beta-hederin and Hederacolchiside A1: triterpenoid saponins bearing a unique cytotoxicity-inducing disaccharide moiety.
Topics: Antineoplastic Agents; Arabinose; Carbohydrate Sequence; Disaccharides; Oleanolic Acid; Rhamnose; Saponins | 2006 |
Phytochemical constituents and hepatoprotective activity of Viburnum tinus.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Evaluation, Preclinical; Iridoids; Lipid Peroxides; Liver; Male; Molecular Structure; Nitric Oxide; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Protective Agents; Rats; Saponins; Viburnum | 2005 |
Cloning and characterization of saponin hydrolases from Aspergillus oryzae and Eupenicillium brefeldianum.
Topics: Amino Acid Sequence; Aspergillus oryzae; Cloning, Molecular; Glycoproteins; Hydrolases; Molecular Weight; Oleanolic Acid; Saponins; Sequence Homology; Substrate Specificity; Trioses | 2005 |
A novel analytical ELISA-based methodology for pharmacologically active saikosaponins.
Topics: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; Bupleurum; Calibration; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cross Reactions; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; Haptens; Hybridomas; Linear Models; Mice; Mice, Inbred BALB C; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Statistics as Topic | 2006 |
Soyasaponin I decreases the expression of alpha2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Cell Movement; Extracellular Matrix; Flow Cytometry; Glycine max; Glycosylation; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Neoplasm Invasiveness; Neoplasm Metastasis; NIH 3T3 Cells; Oleanolic Acid; Saponins; Sialic Acids | 2006 |
The antioxidant activity of a triterpenoid glycoside isolated from the berries of Hedera colchica: 3-O-(beta-D-glucopyranosyl)-hederagenin.
Topics: Antioxidants; Biphenyl Compounds; Fruit; Hedera; Iron Chelating Agents; Molecular Structure; Oleanolic Acid; Picrates; Reducing Agents; Saponins | 2006 |
[Effect of saikosaponins on epileptic seizure and EEG in pentetrazole-induced chronic kindling rats].
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy; Female; Kindling, Neurologic; Male; Oleanolic Acid; Pentylenetetrazole; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2006 |
The isolation of soyasaponins by fractional precipitation, solid phase extraction, and low pressure liquid chromatography.
Topics: Chromatography, Liquid; Fractional Precipitation; Glycine max; Oleanolic Acid; Saponins | 2005 |
Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Autoantibodies; Captopril; Diuretics; Drugs, Chinese Herbal; Edema; Furosemide; Humans; Japan; Male; Mice; Nephritis; Oleanolic Acid; Potassium; Random Allocation; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Saponins; Sodium; Spironolactone | 2006 |
[Studies on fingerprints of Bupleurum chinense from Hebei Province with HPLC-UV].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drug Stability; Oleanolic Acid; Plant Roots; Plants, Medicinal; Powders; Quality Control; Reproducibility of Results; Saponins; Spectrophotometry, Ultraviolet | 2006 |
[Effect of saikosaponins on glial fibrillary acidic protein expression in hippocampal astrocytes of pentetrazole-induced chronic kindling rats].
Topics: Animals; Astrocytes; Bupleurum; Depression, Chemical; Female; Glial Fibrillary Acidic Protein; Hippocampus; Kindling, Neurologic; Male; Oleanolic Acid; Pentylenetetrazole; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2006 |
Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis.
Topics: Animals; Cell Line, Tumor; Cytokines; Drugs, Chinese Herbal; Female; Fibroblasts; Fibrosis; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Oleanolic Acid; Radiodermatitis; Saponins; Skin; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
[Chemical constituents from roots of Ardisia punctata].
Topics: Ardisia; Benzoquinones; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Triterpenes | 2006 |
Visual detection of saikosaponins by on-membrane immunoassay and estimation of traditional Chinese medicines containing Bupleuri radix.
Topics: Bupleurum; Chromatography; Immunoassay; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Saponins; Software | 2006 |
Antiviral effects of saikosaponins on human coronavirus 229E in vitro.
Topics: Antiviral Agents; Cell Line; Cell Survival; Coronavirus 229E, Human; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Oleanolic Acid; Saponins; Time Factors; Virus Replication | 2006 |
Structure-activity relationships of some hederagenin diglycosides: haemolysis, cytotoxicity and apoptosis induction.
Topics: Apoptosis; Arabinose; Cell Line, Tumor; Cell Nucleus; Glucose; Glycosylation; Hemolysis; Humans; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship | 2006 |
Triterpenoid saponins from the stem bark of Caryocar villosum.
Topics: Adipose Tissue; Cell Survival; Cells, Cultured; Humans; Keratinocytes; Lipolysis; Magnoliopsida; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Stems; Sapogenins; Saponins; Structure-Activity Relationship; Tissue Culture Techniques; Triterpenes | 2006 |
[Saikosaponins inhibit increased glutamate and GABA expressions in the hippocampus of pentetrazole-induced slow kindling rats].
Topics: Animals; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Immunohistochemistry; Kindling, Neurologic; Male; Oleanolic Acid; Pentylenetetrazole; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2006 |
Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice.
Topics: Animals; Benzoates; Bridged-Ring Compounds; Cell Adhesion; Cells, Cultured; Concanavalin A; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Flavanones; Glucosides; Glycyrrhizic Acid; Immunosuppressive Agents; Interferon-gamma; Lymphocyte Activation; Lymphocytes; Matrix Metalloproteinase 2; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Monoterpenes; Nitric Oxide; Oleanolic Acid; Picryl Chloride; RNA, Messenger; Saponins; Spleen | 2006 |
Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi.
Topics: Adjuvants, Immunologic; Carbohydrate Sequence; Molecular Sequence Data; Oleanolic Acid; Quillaja; Sapogenins; Saponins; Trisaccharides | 2006 |
[Effect of saikosaponins-d on cyclooxygenase-2 expression of human hepatocellular carcinoma cell line SMMC-7721].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclooxygenase 2; Humans; Oleanolic Acid; Saponins | 2006 |
[Isolation and identification of triterpenoids from root of Achyranthes bidentata in Henan].
Topics: Achyranthes; Molecular Conformation; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2006 |
Quality control of Chinese medicinal preparations LC/ESI(+)/MS/MS analyses of saikosaponins-a and -c as markers of Bupleuri radix samples.
Topics: Calibration; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Quality Control; Reference Standards; Saponins; Spectrometry, Mass, Electrospray Ionization | 2007 |
[Chemical constituents from roots of Platycodon grandiflorum].
Topics: Flavones; Lactones; Oleanolic Acid; Plant Extracts; Plant Roots; Plants, Medicinal; Platycodon; Saponins | 2006 |
Bioactive saponins and glycosides. XXV. Acylated oleanane-type triterpene saponins from the seeds of tea plant (Camellia sinensis).
Topics: Acylation; Camellia sinensis; Glycosides; Magnetic Resonance Spectroscopy; Oleanolic Acid; Saponins; Seeds; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 2007 |
Upregulation of isoprenoid pathway genes during enhanced saikosaponin biosynthesis in the hairy roots of Bupleurum falcatum.
Topics: Amino Acid Sequence; Bupleurum; Gene Expression Regulation, Plant; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Saponins; Sequence Alignment; Terpenes; Up-Regulation | 2006 |
Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Hyaluronic Acid; Laminin; Liver; Liver Cirrhosis, Experimental; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2007 |
A high-performance liquid chromatographic method for saikosaponin a quantification in rat plasma.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Saponins; Scattering, Radiation; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2007 |
Sho-saiko-to (Xiao-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line.
Topics: Cell Line; DNA, Viral; Drugs, Chinese Herbal; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Oleanolic Acid; Plant Extracts; Saponins; Virus Replication | 2007 |
[Saponins from roots of Hedysarum multijugum].
Topics: Fabaceae; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2007 |
Beta1 (KCNMB1) subunits mediate lithocholate activation of large-conductance Ca2+-activated K+ channels and dilation in small, resistance-size arteries.
Topics: Animals; Calcium; Cerebral Arteries; Large-Conductance Calcium-Activated Potassium Channels; Lithocholic Acid; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Protein Subunits; Rats; Rats, Sprague-Dawley; Saponins; Tamoxifen; Vascular Resistance; Vasodilation | 2007 |
Oleanane saponins from Stylosanthes erecta.
Topics: Fabaceae; Mali; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plants, Medicinal; Saponins | 2007 |
[Effect of saikosaponin-d on rat's glomerular mesangial cell proliferation and extracellular matrix hyperplasia in vitro].
Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen Type IV; Cyclin-Dependent Kinase 4; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Flow Cytometry; Hyperplasia; Immunohistochemistry; Immunosuppressive Agents; Lipopolysaccharides; Male; Mesangial Cells; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Transforming Growth Factor beta1 | 2007 |
Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cells, Cultured; Chronic Disease; Collagen Type IV; Cyclin-Dependent Kinase 4; Down-Regulation; Female; Fibrinogen; Glomerulosclerosis, Focal Segmental; JNK Mitogen-Activated Protein Kinases; Male; Mesangial Cells; Oleanolic Acid; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Rats, Wistar; Saponins; Signal Transduction | 2007 |
Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Collagen Type I; Dimethylnitrosamine; Hepatocytes; Liver Cirrhosis, Experimental; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Transforming Growth Factor beta1 | 2007 |
Simultaneous qualification and quantification of eight triterpenoids in radix achyranthis bidentatae by high-performance liquid chromatography with evaporative light scattering detection and mass spectrometric detection.
Topics: Achyranthes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ginsenosides; Molecular Structure; Oleanolic Acid; Plant Roots; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2007 |
[Aike mixture has good anti-inflammatory and analgesic effects on mice].
Topics: Animals; Chronic Disease; Disease Models, Animal; Drug Combinations; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Phytotherapy; Prostatitis; Saponins | 2007 |
[Structural development of root and their relationship to accumulation of triterpenoid saponins in Achyranthes bidentata Bl].
Topics: Achyranthes; Oleanolic Acid; Phloem; Plant Roots; Saponins | 2007 |
Soyasaponins inhibit the proliferation of Hela cells by inducing apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Calcium; Cell Cycle; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Glycine max; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Microscopy, Confocal; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Saponins; Uterine Cervical Neoplasms | 2007 |
[Effect of saikosaponin alpha on experimental epilepsy in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Epilepsy; Female; Male; Oleanolic Acid; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Saponins; Time Factors | 2007 |
[Separation and refine of Xiaoyao Pill by macroporous adsorption resin].
Topics: Adsorption; Benzoates; Bridged-Ring Compounds; Coumaric Acids; Drug Combinations; Drugs, Chinese Herbal; Glucosides; Glycyrrhetinic Acid; Monoterpenes; Oleanolic Acid; Plants, Medicinal; Resins, Synthetic; Saponins; Tablets; Technology, Pharmaceutical | 2007 |
Synthesis, in vitro inhibitory activity towards COX-2 and haemolytic activity of derivatives of esculentoside A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Hemolysis; Humans; Insecta; Oleanolic Acid; Rabbits; Saponins; Structure-Activity Relationship | 2007 |
Cytotoxicity of two triterpenoids from Nigella glandulifera.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Growth Inhibitors; Humans; Mice; Nigella; Oleanolic Acid; Saponins; Triterpenes | 2006 |
[Effects of sapindoside on blood pressure and vasoactive substance in renovascular hypertension rat].
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Drugs, Chinese Herbal; Endothelins; Female; Hypertension, Renovascular; Male; Nitric Oxide; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Sapindus; Saponins | 2007 |
Structural analysis of platycosides in Platycodi Radix by liquid chromatography/electrospray ionization-tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Molecular Structure; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidum.
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Erythrocytes; Fabaceae; Hemolysis; Humans; Molecular Structure; Monoterpenes; Oleanolic Acid; Plant Roots; Plants, Medicinal; Rabbits; Saponins; Triterpenes | 2008 |
[Determination of ardicrenin in Ardisia crenata using RP-HPLC].
Topics: Ardisia; Chromatography, High Pressure Liquid; Molecular Structure; Oleanolic Acid; Reproducibility of Results; Saponins | 2007 |
Effects of Bupleurum scorzoneraefolium, Bupleurum falcatum, and saponins on nephrotoxic serum nephritis in mice.
Topics: Animals; Blood Urea Nitrogen; Bupleurum; Creatinine; Fluorescent Antibody Technique, Direct; Kidney; Mice; Mice, Inbred C57BL; Nephritis; Oleanolic Acid; Phytotherapy; Plant Extracts; Proteinuria; Rabbits; Saponins; Time Factors | 2008 |
Mirabalin, [corrected] an antitumor macrolide lactam from the marine sponge Siliquariaspongia mirabilis.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Macrolides; Marine Biology; Micronesia; Molecular Structure; Oleanolic Acid; Porifera; Saponins | 2008 |
Triterpenoidal saponins from Hydrocotyle sibthorpioides.
Topics: Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 2008 |
Effect of soyasapogenol A and soyasapogenol B concentrated extracts on HEP-G2 cell proliferation and apoptosis.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Line, Tumor; Chromatography, High Pressure Liquid; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Mass Spectrometry; Oleanolic Acid; Plant Extracts; Saponins | 2008 |
Rapid identification of oleanane-type saponins in the roots of Stephanotis mucronata by liquid chromatography/electrospray tandem mass spectrometry.
Topics: Apocynaceae; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors | 2008 |
Two new glucuronide saponins, Achyranthosides G and H, from Achyranthes fauriei root.
Topics: Achyranthes; Glucuronides; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Roots; Saponins | 2008 |
Antiproliferative oleanane saponins from Meryta denhamii.
Topics: Animals; Antineoplastic Agents, Phytogenic; Araliaceae; Drug Screening Assays, Antitumor; Humans; Italy; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plants, Medicinal; Saponins | 2008 |
A convenient preparation of a disaccharide motif and its role in the cytotoxicity of the triterpenoid saponin, alpha-hederin.
Topics: Anisoles; Antineoplastic Agents; Cell Line, Tumor; Disaccharides; Drug Screening Assays, Antitumor; Humans; Oleanolic Acid; Saponins; Triterpenes | 2008 |
[Determination of content of saikoside in Bupleurum Chinense from different sources].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Reproducibility of Results; Saponins | 2008 |
Alpha-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Fluorouracil; HT29 Cells; Humans; Oleanolic Acid; Saponins | 2008 |
Cytotoxic acylated triterpene saponins from the husks of Xanthoceras sorbifolia.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Humans; Inhibitory Concentration 50; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Sapindaceae; Saponins; Triterpenes | 2008 |
The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells.
Topics: Animals; Cell Proliferation; Cell Shape; Cell Survival; Cells, Cultured; Cytoskeleton; Fibroblasts; Humans; Melanoma; Oleanolic Acid; Primulaceae; Saponins; Skin | 2008 |
Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Glutathione; Lipids; Liver; Liver Diseases; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Superoxide Dismutase | 2008 |
Saireito and saikosaponin D prevent urinary protein excretion via glucocorticoid receptor in adrenalectomized WKY rats with heterologous-phase anti-GBM nephritis.
Topics: Adrenalectomy; Animals; Anti-Glomerular Basement Membrane Disease; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Drug Therapy, Combination; Drugs, Chinese Herbal; Interleukin-10; Interleukin-2; Male; Oleanolic Acid; Rats; Rats, Inbred WKY; Receptors, Glucocorticoid; Saponins | 2008 |
[Experimental study of saikosaponin-D (SSd) on lipid peroxidation of hepatic fibrosis on rat].
Topics: Animals; Aspartate Aminotransferases; Collagen Type IV; Dimethylnitrosamine; Hyaluronic Acid; Laminin; Lipid Peroxidation; Liver Cirrhosis; Malondialdehyde; Oleanolic Acid; Rats; Saponins; Superoxide Dismutase | 2008 |
Localization and dynamic change of saikosaponin in root of Bupleurum chinense.
Topics: Biological Transport; Bupleurum; Oleanolic Acid; Plant Roots; Saponins | 2008 |
[Triterpene saponins from Adinandra nitida].
Topics: Glucosides; Molecular Structure; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Saponins; Theaceae | 2008 |
Facile synthesis of oleanolic acid monoglycosides and diglycosides.
Topics: Glycosides; Glycosylation; Oleanolic Acid; Saponins | 2008 |
Characterization and identification of saikosaponins in crude extracts from three Bupleurum species using LC-ESI-MS.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Reference Standards; Saponins; Spectrometry, Mass, Electrospray Ionization | 2008 |
Kalopanaxsaponin A induces apoptosis in human leukemia U937 cells through extracellular Ca2+ influx and caspase-8 dependent pathways.
Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Calcium; Calcium Channel Blockers; Caspase 3; Caspase 8; Caspase 9; Chelating Agents; DNA Fragmentation; Electrophoresis, Agar Gel; Flow Cytometry; Humans; Mitochondria; Oleanolic Acid; Protein Transport; Saponins; U937 Cells | 2008 |
Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.
Topics: Antifungal Agents; Argentina; Cell Membrane; Cell Wall; Glucosyltransferases; Glycosides; Humans; Microscopy, Fluorescence; Oleanolic Acid; Phytolacca; Plants, Medicinal; Saccharomyces cerevisiae; Saponins; Triterpenes | 2008 |
Active component of Fatsia japonica enhances the transduction efficiency of Tat-SOD fusion protein both in vitro and in vivo.
Topics: Animals; Cell Membrane Permeability; Gene Products, tat; HeLa Cells; Humans; Immunohistochemistry; Kinetics; Magnoliopsida; Mice; Oleanolic Acid; Recombinant Fusion Proteins; Saponins; Skin Absorption; Superoxide Dismutase | 2008 |
Synthesis of 7-epineoptilocaulin, mirabilin B, and isoptilocaulin. A unified biosynthetic proposal for the ptilocaulin and batzelladine alkaloids. Synthesis and structure revision of netamines E and G.
Topics: Alkaloids; Oleanolic Acid; Quinazolines; Saponins; Stereoisomerism | 2008 |
[Inhibitory effects of saikosaponin a on rat hippocampal astrocyte activation in vitro].
Topics: Animals; Animals, Newborn; Astrocytes; Cell Proliferation; Cells, Cultured; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 2008 |
[Research on the quality changes in pre-and-post-processed pieces of Radix Polygalae].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Plants, Medicinal; Polygala; Quality Control; Sapogenins; Saponins; Technology, Pharmaceutical | 2008 |
Enhanced triterpene saponin biosynthesis and root nodulation in transgenic barrel medic (Medicago truncatula Gaertn.) expressing a novel beta-amyrin synthase (AsOXA1) gene.
Topics: Aster Plant; Gene Expression; Intramolecular Transferases; Medicago truncatula; Oleanolic Acid; Plant Leaves; Plant Proteins; Plant Roots; Plants, Genetically Modified; RNA, Plant; Saponins; Triterpenes | 2009 |
Application of centrifugal partition chromatography coupled with evaporative light scattering detection for the isolation of saikosaponins-a and -c from Bupleurum falcatum roots.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Light; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Plant Roots; Reproducibility of Results; Saponins; Scattering, Radiation; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2009 |
Isolation of human renin inhibitor from soybean: soyasaponin I is the novel human renin inhibitor in soybean.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Enzyme Inhibitors; Glycine max; Humans; Hypertension; Inhibitory Concentration 50; Kinetics; Male; Oleanolic Acid; Rats; Renin; Saponins | 2008 |
Evaluation of traditional Chinese herbal medicine: Chaihu (Bupleuri Radix) by both high-performance liquid chromatographic and high-performance thin-layer chromatographic fingerprint and chemometric analysis.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drugs, Chinese Herbal; Oleanolic Acid; Pattern Recognition, Automated; Plant Extracts; Quality Control; Saponins; Species Specificity | 2009 |
Liquid chromatography-mass spectrometry analysis of macranthoidin B, macranthoidin A, dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Linear Models; Lonicera; Mass Spectrometry; Oleanolic Acid; Rats; Reproducibility of Results; Saponins; Sensitivity and Specificity; Solid Phase Extraction | 2009 |
Structure elucidation and complete NMR spectral assignment of two triterpenoid saponins from Radix Hedysari.
Topics: Drugs, Chinese Herbal; Fabaceae; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins | 2009 |
Soyasaponin Bh, a triterpene saponin containing a unique hemiacetal-functional five-membered ring from Glycine max (soybeans).
Topics: Glycine max; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 2009 |
Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak.
Topics: Acetylation; Animals; Carbohydrate Conformation; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hypertriglyceridemia; Hypolipidemic Agents; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Sequence Data; Oleanolic Acid; Olive Oil; Plant Bark; Plant Oils; Sapindus; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Triglycerides; Triterpenes | 2009 |
Accumulation and dynamic trends of triterpenoid saponin in vegetative organs of Achyranthus bidentata.
Topics: Achyranthes; Chromatography, High Pressure Liquid; Oleanolic Acid; Plant Leaves; Plant Roots; Plant Stems; Plants, Medicinal; Saponins | 2009 |
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
Topics: Animals; Cell Line, Tumor; Cell Membrane Permeability; Erythrocytes; Hemolysis; Humans; Oleanolic Acid; Saponins; Sheep; Triterpenes | 2009 |
Fast determination of saikosaponins in Bupleurum by rapid resolution liquid chromatography with evaporative light scattering detection.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Cluster Analysis; Light; Oleanolic Acid; Plant Roots; Reference Standards; Reproducibility of Results; Saponins; Scattering, Radiation; Solvents; Spectrophotometry, Ultraviolet | 2009 |
Two triterpenes from Lysimachia foenum-graecum.
Topics: Drugs, Chinese Herbal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Primulaceae; Saponins; Triterpenes | 2009 |
Medicinal Flowers. XXVI. structures of acylated oleanane-type triterpene oligoglycosides, yuchasaponins A, B, C, and D, from the flower buds of Camellia oleifera-gastroprotective, aldose reductase inhibitory, and radical scavenging effects-.
Topics: Aldehyde Reductase; Animals; Anti-Ulcer Agents; Camellia; Flowers; Free Radical Scavengers; Models, Animal; Oleanolic Acid; Plants, Medicinal; Rats; Saponins; Stomach Ulcer; Triterpenes | 2009 |
Cytotoxic oleanane triterpene saponins from Albizia chinensis.
Topics: Albizzia; Animals; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Erythrocytes; Hemolysis; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Rabbits; Saponins | 2009 |
Selective antileishmania activity of 13,28-epoxy-oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae.
Topics: Animals; Antiparasitic Agents; Cell Line; Fibroblasts; Humans; Leishmania infantum; Macrophages; Magnoliopsida; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Oleanolic Acid; Plant Extracts; Primulaceae; Saponins; Structure-Activity Relationship | 2009 |
Evaluation of chikusetsusaponin IVa isolated from Alternanthera philoxeroides for its potency against viral replication.
Topics: Amaranthaceae; Animals; Antiviral Agents; Cell Line; Herpes Genitalis; Herpesvirus 2, Human; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Structure; Oleanolic Acid; Phytotherapy; Plant Extracts; Saponins; Virus Diseases; Virus Replication | 2009 |
Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.
Topics: Cell Line; Cell Line, Tumor; Endocytosis; Hedera; Humans; Oleanolic Acid; Protein Binding; Receptors, Adrenergic, beta-2; Saponins; Thermodynamics | 2009 |
Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa.
Topics: Acetates; Chromatography, High Pressure Liquid; Cyclopentanes; Intramolecular Transferases; Nigella sativa; Oleanolic Acid; Oxylipins; Plant Growth Regulators; Plant Proteins; Saponins; Transcription, Genetic; Yeasts | 2009 |
Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation.
Topics: Animals; Blotting, Western; Cell Proliferation; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NFATC Transcription Factors; Oleanolic Acid; Saponins; Signal Transduction; T-Lymphocytes; Transcription Factor AP-1 | 2009 |
Generation of group B soyasaponins I and III by hydrolysis.
Topics: Chromatography, High Pressure Liquid; Glycine max; Hydrogen-Ion Concentration; Hydrolysis; Isoflavones; Mass Spectrometry; Methanol; Oleanolic Acid; Saponins; Soy Foods; Spectrometry, Mass, Electrospray Ionization | 2009 |
In vitro evaluation of the antiplasmodial activity of Dendropanax morbifera against chloroquine-sensitive strains of Plasmodium falciparum.
Topics: Antimalarials; Araliaceae; Cell Line, Tumor; Chloroquine; Humans; Inhibitory Concentration 50; Molecular Structure; Oleanolic Acid; Plant Extracts; Plasmodium falciparum; Saponins; Triterpenes | 2009 |
Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis.
Topics: Animals; Apoptosis; Autoimmune Diseases; Bupleurum; Cell Cycle; Cell Proliferation; Cyclin D3; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Female; Immunosuppression Therapy; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Oleanolic Acid; Saponins; T-Lymphocytes; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms.
Topics: Animals; Aralia; Calcium Channels, L-Type; Cardiomyopathies; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Heart; Hemodynamics; Male; Myocardium; Oleanolic Acid; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Saponins; Treatment Outcome | 2009 |
A new oleanene triterpene from Gladiolus segetum Ker-Gawl.
Topics: Iridaceae; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Saponins | 2009 |
Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo.
Topics: Animals; Annexin A5; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspases; Cell Line, Tumor; Cell Survival; Female; Flow Cytometry; Humans; Indicators and Reagents; Lonicera; Mice; Mice, Inbred BALB C; Mitochondria; Oleanolic Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Saponins; Signal Transduction; Xenograft Model Antitumor Assays | 2009 |
Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.
Topics: Acetophenones; Animals; Antineoplastic Agents, Phytogenic; Benzopyrans; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Transplantation; NF-kappa B; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transplantation, Heterologous | 2009 |
Triterpenoid saponins from the stems of Clematis parviloba.
Topics: Antineoplastic Agents, Phytogenic; Clematis; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Inhibitory Concentration 50; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Saponins | 2009 |
Platycodin D and 2''-O-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus.
Topics: Animals; Brain Ischemia; Cell Survival; Cyclooxygenase 2; Gerbillinae; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Neuroprotective Agents; NF-kappa B; Oleanolic Acid; Phytotherapy; Plant Extracts; Platycodon; Reperfusion Injury; Saponins; Superoxide Dismutase; Superoxide Dismutase-1; Triterpenes | 2009 |
Facile synthesis of three bidesmosidic oleanolic acid saponins with strong inhibitory activity on pancreatic lipase.
Topics: Dipsacaceae; Enzyme Inhibitors; Glycosylation; Lipase; Oleanolic Acid; Saponins | 2009 |
Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu.
Topics: Animals; Biomimetic Materials; Cell Proliferation; Drug Design; Drugs, Chinese Herbal; HL-60 Cells; Humans; Medicine, Chinese Traditional; Oleanolic Acid; Saponins | 2009 |
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
Topics: Animals; Antineoplastic Agents, Phytogenic; Apiaceae; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Macrophages; Mice; Neoplasms; Nitric Oxide; Oleanolic Acid; Plant Roots; Saponins; Triterpenes | 2009 |
Verbesinosides A-F, 15,27-cyclooleanane saponins from the American native plant Verbesina virginica.
Topics: Flowers; Missouri; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Saponins; Verbesina | 2009 |
Mannosylated saponins based on oleanolic and glycyrrhizic acids. Towards synthetic colloidal antigen delivery systems.
Topics: Animals; Cholesterol; Dendritic Cells; Glycosylation; Glycyrrhizic Acid; Hematopoiesis; Hematopoietic Stem Cells; ISCOMs; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Nanostructures; Oleanolic Acid; Phospholipids; Saponins | 2009 |
Triterpenoid saponins from the roots of Clematis chinensis Osbeck.
Topics: Animals; Clematis; Drugs, Chinese Herbal; Macrophages, Peritoneal; Male; Mice; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2009 |
Bioactive responses of Hep-G2 cells to soyasaponin extracts differs with respect to extraction conditions.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Hepatocytes; Humans; Liver Neoplasms; Oleanolic Acid; Plant Extracts; Saponins; Soybean Proteins; Spectrometry, Mass, Electrospray Ionization; Tetrazolium Salts; Thiazoles | 2009 |
Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis.
Topics: Acetamides; Biological Products; Chloroacetates; Oleanolic Acid; Plant Roots; Pulsatilla; Saponins; Thioglycosides; Trichloroacetic Acid | 2009 |
Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis).
Topics: Acylation; Animals; Camellia sinensis; Flowers; Gastrointestinal Transit; Lipase; Male; Mice; Oleanolic Acid; Plant Extracts; Saponins; Tea; Triterpenes | 2009 |
Isolation and tandem mass fragmentations of an anti-inflammatory compound from Aralia elata.
Topics: Animals; Anti-Inflammatory Agents; Aralia; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; NF-kappa B; Nitric Oxide; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2009 |
[Estrogen-like effects of saikosaponin-d in mice].
Topics: Animals; Estrogens; Female; Mice; Mice, Inbred BALB C; Oleanolic Acid; Ovariectomy; Random Allocation; Saponins | 2009 |
Akebia saponin D, a saponin component from Dipsacus asper Wall, protects PC 12 cells against amyloid-beta induced cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cell Survival; Cytoprotection; Dipsacaceae; Drugs, Chinese Herbal; L-Lactate Dehydrogenase; Oleanolic Acid; PC12 Cells; Rats; Saponins | 2009 |
Structure elucidation and complete NMR spectral assignments of two new oleanane-type pentacyclic triterpenoid saponins from the husks of Xanthoceras sorbifolia Bunge.
Topics: Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Sapindaceae; Saponins | 2009 |
Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak.
Topics: Animals; Glycosides; Inhibitory Concentration 50; Lipase; Molecular Structure; Oleanolic Acid; Pancreas; Plants, Medicinal; Sapindus; Saponins; Swine | 2009 |
[Angiogenesis inhibitory effect of saikosaponin-d on chicken embryo].
Topics: Angiogenesis Inhibitors; Animals; Chick Embryo; Chorioallantoic Membrane; Neovascularization, Physiologic; Oleanolic Acid; Saponins | 2009 |
Two new triterpenoid saponins cytotoxic to human glioblastoma U251MG cells from Ardisia pusilla.
Topics: Antineoplastic Agents, Phytogenic; Ardisia; Astrocytes; Cell Line, Tumor; Glioblastoma; Humans; Molecular Conformation; Oleanolic Acid; Plant Extracts; Saponins; Triterpenes | 2009 |
Cytotoxic acacic acid glycosides from the roots of Albizia coriaria.
Topics: Albizzia; Antineoplastic Agents, Phytogenic; Cameroon; Drug Screening Assays, Antitumor; HCT116 Cells; HT29 Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Triterpenes | 2009 |
A new angeloylated triterpenoid saponin from the husks of Xanthoceras sorbifolia Bunge.
Topics: Oleanolic Acid; Sapindaceae; Saponins; Spectrum Analysis; Triterpenes | 2010 |
Effects of esculentoside A on autoimmune syndrome induced by Campylobacterjejuni in mice and its modulation on T-lymphocyte proliferation and apoptosis.
Topics: Animals; Antigens, CD; Apoptosis; Apoptosis Regulatory Proteins; Autoimmune Diseases; Campylobacter jejuni; Cell Movement; Cell Proliferation; Disease Models, Animal; Immunomodulation; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Phytolacca; Saponins; T-Lymphocytes | 2010 |
Estrogen-like activities of saikosaponin-d in vitro: a pilot study.
Topics: Animals; Blotting, Western; Cell Cycle; Cell Proliferation; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Gene Expression Regulation; HeLa Cells; Humans; Luciferases; Oleanolic Acid; Pilot Projects; Response Elements; RNA, Messenger; Saponins; Transfection | 2010 |
Identification of defense compounds in Barbarea vulgaris against the herbivore Phyllotreta nemorum by an ecometabolomic approach.
Topics: Animals; Barbarea; Chromatography, Liquid; Cluster Analysis; Coleoptera; Crosses, Genetic; Ecosystem; Feeding Behavior; Larva; Mass Spectrometry; Metabolome; Metabolomics; Oleanolic Acid; Plant Leaves; Principal Component Analysis; Saponins; Survival Analysis | 2009 |
Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Ecosystem; Female; Humans; Inhibitory Concentration 50; Lignans; Madagascar; Molecular Structure; Oleanolic Acid; Ovarian Neoplasms; Phytotherapy; Plant Extracts; Plant Roots; Saponins; Terminalia; Triterpenes | 2010 |
Four new cytotoxic oligosaccharidic derivatives of 12-oleanene from Lysimachia heterogenea Klatt.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Oleanolic Acid; Primulaceae; Saponins; Structure-Activity Relationship | 2009 |
Quantification of soyasaponins I and betag in Italian lentil seeds by solid-phase extraction (SPE) and high-performance liquid chromatography-mass spectrometry (HPLC-MS).
Topics: Chromatography, High Pressure Liquid; Italy; Lens Plant; Mass Spectrometry; Oleanolic Acid; Plant Extracts; Saponins; Seeds; Solid Phase Extraction | 2009 |
Triterpene glycosides from Agrostemma gracilis.
Topics: Agrostemma; Glycosides; Molecular Structure; Oleanolic Acid; Plant Extracts; Saponins; Triterpenes | 2010 |
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
Topics: Endothelium; Flavonoids; Free Radical Scavengers; Humans; Italy; Molecular Structure; Oleanolic Acid; Phenols; Plant Leaves; Polyphenols; Rubiaceae; Saponins; Tea | 2010 |
Mirabilins revisited: polyketide alkaloids from a southern Australian marine sponge, Clathria sp.
Topics: Alkaloids; Animals; Australia; Cell Line, Tumor; Humans; Inhibitory Concentration 50; Macrolides; Oleanolic Acid; Porifera; Saponins; Spectrum Analysis | 2010 |
Two new triterpenoid saponins from rhizome of Anemone raddeana Regel.
Topics: Anemone; Oleanolic Acid; Rhizome; Saponins; Triterpenes | 2010 |
Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins.
Topics: Acetylglucosamine; Antineoplastic Agents, Phytogenic; Cell Proliferation; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oleanolic Acid; Saponins; Stomach Neoplasms; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2010 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Curcuma; Curcumin; Cytokines; Dietary Supplements; Drug Therapy, Combination; Fibrosis; Hydroxyproline; Inflammation; Liver; Male; NF-kappa B; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Random Allocation; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Transforming Growth Factor beta1 | 2010 |
Ardipusilloside I purified from Ardisia pusilla competitively binds VEGFR and induces apoptosis in NCI-H460 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Ardisia; bcl-2-Associated X Protein; Binding, Competitive; Cell Line; Cell Nucleus; DNA Breaks; Humans; Lung Neoplasms; Microscopy, Electron, Transmission; Molecular Structure; Oleanolic Acid; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Receptors, Vascular Endothelial Growth Factor; Saponins | 2010 |
Optimization of supercritical fluid extraction of saikosaponins from Bupleurum falcatum with orthogonal array design.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Equipment Design; Ethanol; Oleanolic Acid; Plant Roots; Pressure; Saponins; Temperature; Time Factors | 2010 |
Resistance in the plant, Barbarea vulgaris, and counter-adaptations in flea beetles mediated by saponins.
Topics: Alleles; Animals; Barbarea; Coleoptera; Female; Genotype; Male; Oleanolic Acid; Sapogenins; Saponins | 2010 |
Two new triterpenes from Lysimachia foenum-graecum.
Topics: Drugs, Chinese Herbal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Primulaceae; Saponins | 2009 |
[Study on the optimal extraction process of chaihushugan powder].
Topics: Benzoates; Bridged-Ring Compounds; Bupleurum; Chromatography, High Pressure Liquid; Coumaric Acids; Drug Combinations; Drugs, Chinese Herbal; Ethanol; Glucosides; Hesperidin; Hot Temperature; Monoterpenes; Oleanolic Acid; Plants, Medicinal; Powders; Quality Control; Saponins; Solubility; Technology, Pharmaceutical; Time Factors | 2009 |
Two new compounds from Semen celosiae and their protective effects against CCl₄-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride Poisoning; Celosia; Chemical and Drug Induced Liver Injury; Mice; Molecular Structure; Oleanolic Acid; Saponins; Seeds | 2011 |
A new triterpenoid saponin from the stem bark of Pometia pinnata.
Topics: Molecular Structure; Oleanolic Acid; Plant Bark; Plant Stems; Sapindaceae; Saponins | 2010 |
27-Hydroxyoleanolic acid type triterpenoid saponins from Anemone raddeana rhizome.
Topics: Anemone; Molecular Structure; Oleanolic Acid; Rhizome; Saponins; Triterpenes | 2010 |
Group B oleanane triterpenoid extract containing soyasaponins I and III from soy flour induces apoptosis in Hep-G2 cells.
Topics: Cell Line, Tumor; Chromatography, High Pressure Liquid; Flour; Flow Cytometry; Glycine max; Humans; In Situ Nick-End Labeling; Oleanolic Acid; Plant Extracts; Saponins; Triterpenes | 2010 |
Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula.
Topics: Cloning, Molecular; Cluster Analysis; Cytochrome P-450 Enzyme System; DNA, Plant; Escherichia coli; Gene Expression Regulation, Plant; Glycosylation; Glycosyltransferases; Hydroxylation; Medicago truncatula; Oleanolic Acid; Oligonucleotide Array Sequence Analysis; Plant Proteins; Retroelements; Saponins; Substrate Specificity; Triterpenes | 2010 |
Identification and characterization of glycosyltransferases involved in the biosynthesis of soyasaponin I in Glycine max.
Topics: Glycine max; Glycosyltransferases; Oleanolic Acid; Saponins; Triterpenes | 2010 |
[Differences of saikosaponin contents in Bupleurum chinense from habitats in Dongling Mountain & Wuling Mountain of Beijing].
Topics: Bupleurum; China; Chromatography, High Pressure Liquid; DNA Primers; Ecosystem; Oleanolic Acid; Saponins | 2009 |
Murine metabolism and absorption of lancemaside A, an active compound in the roots of Codonopsis lanceolata.
Topics: Administration, Oral; Animals; Cecum; Chromatography, Liquid; Codonopsis; Esters; Male; Mass Spectrometry; Mice; Molecular Structure; Oleanolic Acid; Plant Roots; Saponins | 2010 |
Two new triterpenes from Lysimachia foenum-graecum.
Topics: Drugs, Chinese Herbal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Primulaceae; Saponins | 2010 |
Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS.
Topics: Animals; Calibration; Chemistry Techniques, Analytical; Chromatography; Ions; Mass Spectrometry; Models, Chemical; Mollusca; Oleanolic Acid; Primulaceae; Reproducibility of Results; Saponins; Sensitivity and Specificity; Sodium; Tandem Mass Spectrometry | 2010 |
[Therapeutic effects and mechanism of saikosaponin-d in mice with bleomycin-induced pulmonary fibrosis].
Topics: Animals; Bleomycin; Female; Lung; Male; Mice; Mice, Inbred Strains; Oleanolic Acid; Phytotherapy; Pulmonary Fibrosis; Saponins | 2010 |
Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Oleanolic Acid; Plant Extracts; Saponins | 2010 |
Inhibition of human renin activity by saponins.
Topics: Fruit; Glycine max; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Oleanolic Acid; Renin; Saponins | 2010 |
Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Oleanolic Acid; Plant Roots; Saponins; Solvents; Spectrophotometry, Ultraviolet; Temperature | 2010 |
Identification and determination of the saikosaponins in Radix bupleuri by accelerated solvent extraction combined with rapid-resolution LC-MS.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ethanol; Mass Spectrometry; Medicine, Chinese Traditional; Molecular Conformation; Oleanolic Acid; Plant Extracts; Saponins; Stereoisomerism | 2010 |
Enzymatic transformation of platycosides and one-step separation of platycodin D by high-speed countercurrent chromatography.
Topics: Cellulase; Chromatography, High Pressure Liquid; Molecular Conformation; Oleanolic Acid; Platycodon; Saponins | 2010 |
Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clematis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Plant Roots; Rhizome; Saponins; Triterpenes | 2010 |
Two new triterpenoid saponins from Dianthus superbus L.
Topics: Dianthus; Drugs, Chinese Herbal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins | 2010 |
Three new oleanane triterpenoid saponins acetylated with monoterpenoid acid from Albizia julibrissin.
Topics: Albizzia; Molecular Structure; Monoterpenes; Oleanolic Acid; Plant Bark; Plant Extracts; Plant Stems; Saponins | 2010 |
A sensitive liquid chromatography-electrospray tandem mass spectrometric method for lancemaside A and its metabolites in plasma and a pharmacokinetic study in mice.
Topics: Animals; Bacteria; Chromatography, Liquid; Feces; Gastrointestinal Tract; Humans; Male; Metagenome; Mice; Mice, Inbred ICR; Oleanolic Acid; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
[HPLC determination of chikusetsusaponin IVa in Rhizoma Panacis Majoris from different producing areas].
Topics: Chromatography, High Pressure Liquid; Linear Models; Oleanolic Acid; Panax; Reproducibility of Results; Rhizome; Saponins | 2010 |
[Study on the chemical constituents from pine needles of Cedrus deodara].
Topics: Cedrus; Chromatography, Thin Layer; Laurates; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Leaves; Saponins; Shikimic Acid; Sitosterols; Stearates | 2010 |
African descents are more sensitive than European descents to the antitumor compounds α-hederin and kalopanaxsaponin I.
Topics: Animals; Antineoplastic Agents, Phytogenic; Black People; Cell Line, Tumor; Growth Inhibitors; Humans; Lymphocyte Activation; Mice; Neoplasms; Nigella; Oleanolic Acid; Pharmacogenetics; Phytotherapy; Plant Extracts; Polymorphism, Single Nucleotide; Saponins; Seeds; White People | 2010 |
The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation.
Topics: Calcium; Cyclic AMP; Free Radical Scavengers; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase Kinases; Molecular Structure; NADPH Oxidases; Neutrophil Activation; Oleanolic Acid; Pancreatic Elastase; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Receptors, Formyl Peptide; Sapindus; Saponins | 2010 |
Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle.
Topics: Adrenergic beta-Agonists; Animals; Bronchodilator Agents; Cattle; Drug Synergism; Hedera; Histamine; Isoproterenol; Methacholine Chloride; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oleanolic Acid; Plant Extracts; Plant Leaves; Saponins; Trachea | 2011 |
[Apoptosis effects on human esophageal cancer cells by soyasaponin Bb and its machanism].
Topics: Apoptosis; Cell Line, Tumor; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Oleanolic Acid; Saponins | 2010 |
An LC-MS method for simultaneous determination of nine ginsenosides in rat plasma and its application in pharmacokinetic study.
Topics: Animals; Area Under Curve; Chromatography, Liquid; Drug Stability; Drugs, Chinese Herbal; Ginsenosides; Linear Models; Male; Oleanolic Acid; Rats; Rats, Wistar; Reproducibility of Results; Saponins; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization | 2011 |
Triterpenoid saponins from the rhizome of Polygonatum sibiricum.
Topics: Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Polygonatum; Rhizome; Saponins; Triterpenes | 2010 |
[Study on hepatotoxicity on rats caused by crude extracts of total saikosaponins and correlation with oxidative damage mechanism].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Liver; Male; Malondialdehyde; Oleanolic Acid; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Saponins; Superoxide Dismutase | 2010 |
Characterization and identification of saponins in Achyranthes bidentata by rapid-resolution liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Topics: Achyranthes; Chromatography, Liquid; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
[Studies on the lowering blood sugar substances from agrimony (II)].
Topics: Agrimonia; Apigenin; Ellagic Acid; Hypoglycemic Agents; Luteolin; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Components, Aerial; Plants, Medicinal; Saponins; Triterpenes; Ursolic Acid | 2010 |
Soyasaponin I attenuates TNBS-Induced colitis in mice by inhibiting NF-κB pathway.
Topics: Animals; Colitis; Cyclooxygenase 2; Glycine max; Humans; Interleukin-1; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Plant Extracts; Saponins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
[Breeding of new varieties "zhongchai no. 2" and "zhongchai no. 3" of Bupleurum chinense].
Topics: Breeding; Bupleurum; Oleanolic Acid; Plant Extracts; Saponins | 2010 |
Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Male; Mice; Oleanolic Acid; Pain; Phytotherapy; Plant Bark; Plant Extracts; Quillaja; Saponins; Triterpenes | 2011 |
Structural characterization and identification of oleanane-type triterpene saponins in Glycyrrhiza uralensis Fischer by rapid-resolution liquid chromatography coupled with time-of-flight mass spectrometry.
Topics: Chromatography, Liquid; Glycyrrhiza uralensis; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2010 |
28-nor-oleanane-type triterpene saponins from Camellia japonica and their inhibitory activity on LPS-induced NO production in macrophage RAW264.7 cells.
Topics: Camellia; Lipopolysaccharides; Macrophages; Magnetic Resonance Spectroscopy; Molecular Conformation; Nitric Oxide; Oleanolic Acid; Plant Bark; Saponins | 2010 |
[Effects of fulvotomentoside on inflammatory factors and antiinflammatory factors in intestine of ovalbumin-sensitized BALB/c mice].
Topics: Animals; Female; Food Hypersensitivity; Forkhead Transcription Factors; Inflammation; Interleukin-17; Interleukin-6; Intestinal Mucosa; Intestines; Mice; Mice, Inbred BALB C; Oleanolic Acid; Ovalbumin; Saponins; Transforming Growth Factor beta1 | 2010 |
Synthesis and tumor cytotoxicity of novel amide derivatives of β-hederin.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship | 2010 |
Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines.
Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Caspase 2; Caspase 8; Caspase 9; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Flow Cytometry; Humans; Inhibitor of Apoptosis Proteins; Mitochondria; Oleanolic Acid; Oligopeptides; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Saponins; Signal Transduction; Survivin | 2011 |
Separation and identification of a new saponin from the flowers of Guaiacum officinale L.
Topics: Flowers; Guaiacum; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oleanolic Acid; Plant Extracts; Saponins | 2010 |
["Dose-toxicity" relationship study on rat's chronic hepatoxicity of refined products of saikosaponin by alcohol elution].
Topics: Animals; Bupleurum; Dose-Response Relationship, Drug; Ethanol; Female; Humans; Liver; Male; Oleanolic Acid; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Saponins | 2010 |
Medicinal Flowers. XXXI. Acylated oleanane-type triterpene saponins, Sasanquasaponins I-V, with antiallergic activity from the flower buds of Camellia sasanqua.
Topics: Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Camellia; Cell Line, Tumor; Flowers; Leukemia, Basophilic, Acute; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Rats; Saponins; Structure-Activity Relationship; Triterpenes | 2010 |
Preparation of knockout extract for determination of really active compound using MAb.
Topics: Antibodies, Monoclonal; Chromatography, Affinity; Complex Mixtures; Ginsenosides; Glycyrrhizic Acid; Immunoassay; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Panax; Plant Extracts; Rhizome; Saponins | 2011 |
Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Separation; Cisplatin; Flow Cytometry; Humans; Neoplasms; Oleanolic Acid; Reactive Oxygen Species; Saponins | 2010 |
Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry.
Topics: Administration, Oral; Animals; Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Flavonoids; Glucosides; Glucuronides; Medicine, Chinese Traditional; Oleanolic Acid; Rats; Saponins; Scutellaria baicalensis; Spectrometry, Mass, Electrospray Ionization | 2010 |
Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Interleukin-1 Receptor-Associated Kinases; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; Oleanolic Acid; Saponins; Sulfasalazine | 2011 |
[Study on dynamic accumulation of index components from Bupleurum chinense in various collecting periods].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Oils, Volatile; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Seasons; Spectrophotometry, Ultraviolet | 2010 |
Glaucasides A-C, three saikosaponins from Atriplex glauca L. var. ifiniensis (Caball) Maire.
Topics: Atriplex; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Fast Atom Bombardment | 2011 |
Analysis of saikosaponins in Bupleuri Radix and Caihu-shugan-san using reversed-phase HPLC with pulsed amperometric detection.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drugs, Chinese Herbal; Oleanolic Acid; Saponins | 2011 |
Cytotoxic oleanane-type saponins from Albizia inundata.
Topics: Albizzia; Antineoplastic Agents, Phytogenic; Argentina; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Stereoisomerism | 2011 |
Fast and sensitive LC-DAD-ESI/MS method for analysis of saikosaponins c, a, and d from the roots of Bupleurum Falcatum (Sandaochaihu).
Topics: Bupleurum; Chromatography, Liquid; Limit of Detection; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Plant Roots; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2011 |
Apoptosis and membrane permeabilisation induced by macranthoside B on HL-60 cells.
Topics: Apoptosis; Caspase 3; Cell Membrane Permeability; HL-60 Cells; Humans; Lonicera; Molecular Structure; Oleanolic Acid; Saponins | 2011 |
Cytotoxic triterpenoid saponins from the rhizomes of Anemone taipaiensis.
Topics: Anemone; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Humans; Molecular Structure; Oleanolic Acid; Plant Extracts; Rhizome; Saponins | 2011 |
Unusual oleanane-type saponins from Arenaria montana.
Topics: Antineoplastic Agents; Arenaria Plant; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oleanolic Acid; Saponins; Stereoisomerism | 2011 |
Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW 264.7 cells by attenuation of NF-κB-mediated nitric oxide synthase expression.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Lipopolysaccharides; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Saponins; Tumor Necrosis Factor-alpha | 2011 |
Bioactive saponins from Microsechium helleri and Sicyos bulbosus.
Topics: Animals; Antinematodal Agents; Cucurbitaceae; Cytotoxins; Larva; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Saponins; Spodoptera | 2011 |
Soyasapogenol B and trans-22-dehydrocam- pesterol from common vetch (Vicia sativa L.) root exudates stimulate broomrape seed germination.
Topics: Cholestadienols; Germination; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Orobanche; Phytosterols; Plant Exudates; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Vicia sativa | 2011 |
Oleanane-type triterpene saponins and cassaine-type diterpenoids from Erythrophleum fordii.
Topics: Abietanes; Alkaloids; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Diterpenes; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Fabaceae; Female; Glycosides; Humans; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Saponins | 2011 |
A new triterpene saponin from Androsace integra.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Structure; Oleanolic Acid; Phytotherapy; Plant Extracts; Primulaceae; Saponins; Triterpenes | 2011 |
Rapid profiling and identification of triterpenoid saponins in crude extracts from Albizia julibrissin Durazz. by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Topics: Albizzia; Chromatography, High Pressure Liquid; Chromatography, Liquid; Complex Mixtures; Electrolytes; Ions; Mass Spectrometry; Models, Chemical; Oleanolic Acid; Plant Extracts; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terpenes | 2011 |
Inactivation of cystein-aspartic acid protease (caspase)-1 by saikosaponin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 1; Caspase Inhibitors; Cell Line; Cell Nucleus; Cytokines; Enzyme Activation; Female; Gene Expression Regulation; Genes, Reporter; Humans; I-kappa B Proteins; MAP Kinase Signaling System; Mast Cells; Mice; Mice, Inbred BALB C; NF-kappa B; Oleanolic Acid; Protein Transport; Rhinitis; RNA, Messenger; Saponins; Specific Pathogen-Free Organisms | 2011 |
[Quality inspection of commercial Bupluri Radix samples in Guangzhou: an ELISA for determining saikosaponin A content using anti-saikosaponin A monoclonal antibody].
Topics: Antibodies, Monoclonal; Bupleurum; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Oleanolic Acid; Quality Control; Saponins | 2011 |
Medicinal Flowers. XXXII. Structures of oleanane-type triterpene saponins, perennisosides VIII, IX, X, XI, and XII, from the flowers of Bellis perennis.
Topics: Animals; Asteraceae; Flowers; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Oleanolic Acid; Olive Oil; Plant Oils; Plants, Medicinal; Saponins; Stereoisomerism; Stomach Diseases | 2011 |
[Triterpenoid saponins of Alternanthera philoxeroides (Mart.) Griseb].
Topics: Amaranthaceae; Antiviral Agents; Hep G2 Cells; Hepatitis B virus; Humans; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes | 2011 |
Inhibitory effects of three oleanolic acid glycosides from Achyranthes japonica on the complement classical pathway.
Topics: Achyranthes; Animals; Chloroform; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Complement Inactivating Agents; Complement Pathway, Classical; Hemolysis; Inhibitory Concentration 50; Oleanolic Acid; Plant Extracts; Rabbits; Saponins; Sheep | 2012 |
Bioactive saponins from the fruits of Aesculus pavia L.
Topics: Aesculus; Amniotic Fluid; Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Fruit; Humans; Lung Neoplasms; Oleanolic Acid; Phytotherapy; Plant Extracts; Saponins | 2011 |
Constituents of the root of Anemone tomentosa.
Topics: Anemone; Betulinic Acid; Coumarins; Drugs, Chinese Herbal; Free Radical Scavengers; Glycosides; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Phytosterols; Phytotherapy; Plant Roots; Saponins; Sterols; Structure-Activity Relationship; Triterpenes | 2011 |
Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins.
Topics: Animals; Base Sequence; Cattle; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Glycosylation; Hemolytic Agents; Humans; Medicago truncatula; Molecular Sequence Data; Mutation; Oleanolic Acid; Oxidation-Reduction; Plant Leaves; Plant Proteins; Plant Roots; Plants, Genetically Modified; Saccharomyces cerevisiae; Sapogenins; Saponins; Transcriptome | 2011 |
Triterpenoid saponins from Dipsacus asper and their activities in vitro.
Topics: Alkaline Phosphatase; Dipsacaceae; Molecular Structure; Oleanolic Acid; Saponins; Stereoisomerism | 2011 |
Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway.
Topics: Anti-Infective Agents; Aralia; Hep G2 Cells; Humans; NF-kappa B; Oleanolic Acid; Peroxisome Proliferator-Activated Receptors; Plant Bark; Saponins | 2011 |
Kalopanaxsaponins A and B isolated from Kalopanax pictus ameliorate memory deficits in mice.
Topics: Acetylcholinesterase; Animals; Brain-Derived Neurotrophic Factor; Butanols; Cholinesterase Inhibitors; Cyclic AMP Response Element-Binding Protein; Drug Evaluation, Preclinical; Enzyme Activation; Kalopanax; Maze Learning; Memory; Memory Disorders; Methanol; Mice; Mice, Inbred ICR; Nootropic Agents; Oleanolic Acid; Phosphorylation; Phytotherapy; Plant Bark; Saponins; Scopolamine; Tumor Necrosis Factor-alpha | 2012 |
Large-scale production of saikosaponins through root culturing of Bupleurum falcatum L. using modified airlift reactors.
Topics: Bioreactors; Bupleurum; Culture Media; Oleanolic Acid; Plant Roots; Saponins; Tissue Culture Techniques | 2012 |
Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Drug Stability; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
Two new triterpenoid glycosides from the leaves of Anthocephalus chinensis.
Topics: Drugs, Chinese Herbal; Glucosides; Glycosides; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Rubiaceae; Saponins; Stereoisomerism; Triterpenes; Ursolic Acid | 2011 |
Analysis of saikosaponins in rat plasma by anionic adducts-based liquid chromatography tandem mass spectrometry method.
Topics: Animals; Anions; Chromatography, Liquid; Digoxin; Drug Stability; Drugs, Chinese Herbal; Linear Models; Liquid-Liquid Extraction; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Synthesis of novel derivatives of esculentoside A and its aglycone phytolaccagenin, and evaluation of their haemolytic activity and inhibition of lipopolysaccharide-induced nitric oxide production.
Topics: Animals; Cell Survival; Drug Evaluation, Preclinical; Erythrocytes; Hemolytic Agents; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Nitric Oxide; Oleanolic Acid; Phytolacca; Rabbits; Saponins; Structure-Activity Relationship | 2011 |
[Chemical constitutents from pre-formulation of lonicerae japonicae flos in shuanghuanglian lyophilized powder for injection].
Topics: Chlorogenic Acid; Drugs, Chinese Herbal; Flowers; Freeze Drying; Lonicera; Oleanolic Acid; Quinic Acid; Rutin; Saponins | 2011 |
[Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity].
Topics: Catechin; Cell Line; Fabaceae; Gallic Acid; Humans; Inhibitory Concentration 50; Oleanolic Acid; Plant Extracts; Plant Roots; Plants, Medicinal; Saponins; Triterpenes | 2011 |
Oleanene glycosides of the aerial parts and seeds of Bupleurum falcatum and the aerial parts of Bupleurum rotundifolium, and their evaluation as anti-hepatitis agents.
Topics: Animals; Bupleurum; Cells, Cultured; Hepatocytes; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Oleanolic Acid; Plant Components, Aerial; Protective Agents; Rabbits; Rats; Rats, Wistar; Saponins; Seeds | 2011 |
Oleanolic triterpene saponins from the roots of Panax bipinnatifidus.
Topics: Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Panax; Plant Roots; Saponins; Triterpenes | 2011 |
Transcriptome analysis of Bupleurum chinense focusing on genes involved in the biosynthesis of saikosaponins.
Topics: Bupleurum; Cytochrome P-450 Enzyme System; DNA, Plant; Expressed Sequence Tags; Gene Library; Genes, Plant; Glucuronosyltransferase; Molecular Sequence Annotation; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Sequence Analysis, DNA; Transcriptome | 2011 |
Interaction of the main components from the traditional Chinese drug pair Chaihu-Shaoyao based on rat intestinal absorption.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bridged-Ring Compounds; Bupleurum; Drugs, Chinese Herbal; Glucosides; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Medicine, Chinese Traditional; Molecular Structure; Monoterpenes; Oleanolic Acid; Paeonia; Rats; Rats, Sprague-Dawley; Saponins | 2011 |
Species discrimination of Radix Bupleuri through the simultaneous determination of ten saikosaponins by high performance liquid chromatography with evaporative light scattering detection and electrospray ionization mass spectrometry.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Cluster Analysis; Drugs, Chinese Herbal; Light; Limit of Detection; Linear Models; Oleanolic Acid; Plant Roots; Reproducibility of Results; Saponins; Scattering, Radiation; Species Specificity; Spectrometry, Mass, Electrospray Ionization | 2011 |
Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: involvement of CCAAT/enhancer binding protein β and cyclooxygenase-2.
Topics: Animals; Bupleurum; CCAAT-Enhancer-Binding Protein-beta; Chemoprevention; Cyclooxygenase 2; Diethylnitrosamine; Immunohistochemistry; Liver Neoplasms, Experimental; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 2012 |
Effects of five oleanolic acid triterpenoid saponins from the rhizome of Anemone raddeana on stimulus-induced superoxide generation, phosphorylation of proteins and translocation of cytosolic compounds to cell membrane in human neutrophils.
Topics: Anemone; Antibodies, Monoclonal; Cell Membrane; Dose-Response Relationship, Drug; Humans; NADPH Oxidases; Neutrophils; Oleanolic Acid; Phosphoproteins; Phosphorylation; Protein Transport; rac GTP-Binding Proteins; Rhizome; Saponins; Superoxides; Triterpenes | 2012 |
A new triterpenoid saponin from Abrus precatorius Linn.
Topics: Abrus; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Oleanolic Acid; Plant Extracts; Saponins; Triterpenes | 2011 |
Two new oleanane-type pentacyclic triterpenoid saponins from the husks of Xanthoceras sorbifolia Bunge.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Sapindaceae; Saponins | 2012 |
[Research on mechanism of energy metabolism disorders of rat's hepatoxicity induced by saikosaponins].
Topics: Animals; Antimetabolites; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Transport; Energy Metabolism; Female; Liver; Male; Mitochondria, Liver; Oleanolic Acid; Organ Size; Rats; Saponins | 2011 |
Inhibition of tumor-induced angiogenesis and its mechanism by ardipusilloside I purified from Ardisia pusilla.
Topics: Angiogenesis Inhibitors; Animals; Ardisia; Chickens; Dose-Response Relationship, Drug; Humans; Mice; Oleanolic Acid; Saponins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2012 |
Quantitative analysis of acylated oleanane-type triterpene saponins, chakasaponins I-III and floratheasaponins A-F, in the flower buds of Camellia sinensis from different regional origins.
Topics: Camellia sinensis; China; Flowers; India; Japan; Oleanolic Acid; Saponins; Taiwan; Triterpenes | 2012 |
Metabolism and pharmacokinetic study of ardipusilloside I in rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Ardisia; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Injections, Intravenous; Intestine, Small; Linear Models; Models, Animal; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Validated LC-MS/MS assay for the quantitative determination of clematichinenoside AR in rat plasma and its application to a pharmacokinetic study.
Topics: Animals; Chromatography, Liquid; Drug Stability; Linear Models; Oleanolic Acid; Rats; Reproducibility of Results; Saponins; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Ardisia; Blotting, Western; Cadherins; Carcinoma, Hepatocellular; cdc42 GTP-Binding Protein; Cell Movement; Cell Proliferation; Cell Survival; Collagenases; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oleanolic Acid; Phytotherapy; Protein Serine-Threonine Kinases; rac1 GTP-Binding Protein; Saponins | 2012 |
Acylated flavonol glycosides from Epimedium elatum, a plant endemic to the Western Himalayas.
Topics: Animals; Anti-Infective Agents; Asia; Cell Line; Drugs, Chinese Herbal; Epimedium; Haplorhini; Kidney; Medicine, Chinese Traditional; Oleanolic Acid; PPAR gamma; Saponins | 2012 |
Study on the noncovalent interactions of saikosaponins and cytochrome c by electrospray ionization mass spectrometry.
Topics: Animals; Bupleurum; Cytochromes c; Horses; Oleanolic Acid; Oligosaccharides; Protein Binding; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2012 |
Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Female; Humans; Matrix Metalloproteinase 9; Mice; Mice, Nude; Mouth Neoplasms; Neoplasm Invasiveness; Oleanolic Acid; Protein Transport; RNA, Messenger; Saponins; Tetradecanoylphorbol Acetate; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1).
Topics: Dammaranes; Fruit; Ginsenosides; Japan; Oleanolic Acid; Panax; Plant Extracts; Saponins; Triterpenes | 2012 |
Two new oleanane-type saponins from the husks of Xanthoceras sorbifolia Bunge.
Topics: Cell Line, Tumor; Cell Proliferation; Hep G2 Cells; Humans; Oleanolic Acid; Saponins | 2013 |
Procoagulant and prothrombotic effects of the herbal medicine, Dipsacus asper and its active ingredient, dipsacus saponin C, on human platelets.
Topics: Adenosine Triphosphate; Adolescent; Adult; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blood Coagulation; Blood Platelets; Calcium; Caspase 3; Cell-Derived Microparticles; Chelating Agents; Coagulants; Cytochromes c; Dipsacaceae; Dose-Response Relationship, Drug; Egtazic Acid; Humans; Male; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; Partial Thromboplastin Time; Phosphatidylserines; Phospholipid Transfer Proteins; Plant Preparations; Plant Roots; Platelet Activation; Prothrombin Time; Rats; Rats, Sprague-Dawley; Risk Assessment; Risk Factors; Saponins; Thrombosis; Time Factors; Young Adult | 2012 |
[Effect of Saikosaponins-d on reversing malignant phenotype of HepG2 cells in vitro].
Topics: Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neoplasms; Oleanolic Acid; RNA, Messenger; Saponins | 2011 |
Two new triterpenoid saponins from the husks of Xanthoceras sorbifolia.
Topics: Cell Line, Tumor; Cell Proliferation; Humans; Magnetic Resonance Spectroscopy; Oleanolic Acid; Sapindaceae; Saponins; Spectrometry, Mass, Electrospray Ionization | 2013 |
Participation of cholinergic pathways in α-hederin-induced contraction of rat isolated stomach strips.
Topics: Acetylcholine; Animals; Araliaceae; Atropine; Cholinergic Agents; Hexamethonium; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Oleanolic Acid; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Reference Values; Saponins; Signal Transduction; Stomach | 2012 |
Triterpenes from Callicarpa integerrima Champ.
Topics: Betulinic Acid; Callicarpa; Molecular Conformation; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Plant Stems; Plants, Medicinal; Saponins; Triterpenes; Ursolic Acid | 2012 |
[Effects of interferon-alpha combined with saikosaponin on serum T lymphocyte subgroups and hepatic cytokines in mice with immune hepatic injury].
Topics: Animals; Cytokines; Hepatitis, Autoimmune; Interferon-alpha; Liver; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Saponins; T-Lymphocyte Subsets | 2012 |
[Optimization of the ultrasound assisted extraction of saikosaponins from Bupleurum falcatum using response surface methodology].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Ethanol; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Solvents; Temperature; Time Factors; Ultrasonics | 2011 |
Paviosides A-H, eight new oleane type saponins from Aesculus pavia with cytotoxic activity.
Topics: Aesculus; Animals; Carbohydrate Sequence; Cell Line, Tumor; Cell Survival; Fibrosarcoma; Macrophages; Magnetic Resonance Spectroscopy; Mice; Molecular Sequence Data; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Saponins | 2012 |
Metabolic fingerprinting by 1HNMR for discrimination of the two species used as Radix Bupleuri.
Topics: Arginine; Bupleurum; China; Citric Acid; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Metabolomics; Multivariate Analysis; Oils, Volatile; Oleanolic Acid; Phylogeography; Principal Component Analysis; Saponins; Sucrose | 2012 |
Analysis of isoflavone, phenolic, soyasapogenol, and tocopherol compounds in soybean [ Glycine max (L.) Merrill] germplasms of different seed weights and origins.
Topics: Antioxidants; China; Glycine max; Isoflavones; Oleanolic Acid; Phenols; Republic of Korea; Saponins; Seeds; Tocopherols; United States | 2012 |
Saikosaponin-d inhibits β-conglycinin induced activation of rat basophilic leukemia-2H3 cells.
Topics: Animals; Anti-Allergic Agents; Antigens, Plant; beta-N-Acetylhexosaminidases; Calcium Signaling; Cell Degranulation; Cell Line, Tumor; Food Hypersensitivity; Globulins; Glycine max; Humans; Immunoglobulin E; Leukemia, Basophilic, Acute; Mast Cells; Medicine, Chinese Traditional; Oleanolic Acid; Phosphorylation; Rats; Reactive Oxygen Species; Saponins; Seed Storage Proteins; Signal Transduction; Soybean Proteins; Tyrosine | 2012 |
Response surface methodology to optimize enzymatic preparation of Deapio-Platycodin D and Platycodin D from Radix Platycodi.
Topics: Hydrolysis; Medicine, Chinese Traditional; Models, Statistical; Oleanolic Acid; Plant Extracts; Plant Roots; Platycodon; Saponins; Triterpenes | 2012 |
An in vitro study on the DNA damaging effects of phytochemicals partially isolated from an extract of Glinus lotoides.
Topics: Animals; Cell Line, Tumor; Chromatography, Liquid; Comet Assay; DNA Damage; Mice; Molluginaceae; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Saponins; Tandem Mass Spectrometry; Triterpenes | 2013 |
β-Amyrin oxidation by oat CYP51H10 expressed heterologously in yeast cells: the first example of CYP51-dependent metabolism other than the 14-demethylation of sterol precursors.
Topics: Avena; Genes, Plant; Oleanolic Acid; Phytosterols; Saponins; Sterol 14-Demethylase; Yeasts | 2012 |
Medicinal flowers. XXXVI.1) Acylated oleanane-type triterpene saponins with inhibitory effects on melanogenesis from the flower buds of Chinese Camellia japonica.
Topics: Acylation; Animals; Antineoplastic Agents; Camellia; Cell Survival; Flowers; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Melanoma, Experimental; Methanol; Mice; Molecular Structure; Oleanolic Acid; Saponins | 2012 |
Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupleurum; Capillary Permeability; Cell Line; Cyclooxygenase 2; Cytokines; Immunosuppression Therapy; Inflammation Mediators; Lipopolysaccharides; Macrophages; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Saponins; Signal Transduction; Stereoisomerism; Transcriptional Activation | 2012 |
Evaluation of novel saponins from Psammosilene tunicoides and their analogs as immunomodulators.
Topics: Amides; Animals; Carbohydrates; Caryophyllaceae; Cells, Cultured; Hemolysis; Hydrophobic and Hydrophilic Interactions; Immunity, Cellular; Immunity, Humoral; Immunologic Factors; Immunomodulation; Liver; Mice; Mice, Inbred ICR; Oleanolic Acid; Rabbits; Saponins; Structure-Activity Relationship | 2012 |
Solubilization of saikosaponin a by ginsenoside Ro biosurfactant in aqueous solution: mesoscopic simulation.
Topics: Computer Simulation; Ginsenosides; Humans; Medicine, Chinese Traditional; Micelles; Microscopy, Electron, Transmission; Models, Chemical; Oleanolic Acid; Panax; Saponins; Scattering, Small Angle; Solubility; Solutions; Surface-Active Agents; Thermodynamics; Water; X-Ray Diffraction | 2012 |
NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway.
Topics: 4-Aminobenzoic Acid; Animals; Antineoplastic Agents; Apoptosis; Azo Compounds; Carcinoma, Hepatocellular; Cell Proliferation; Hep G2 Cells; Humans; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice; Mitochondria; Nitric Oxide; Oleanolic Acid; Reactive Oxygen Species; Saponins; Xenograft Model Antitumor Assays | 2012 |
Melanogenesis inhibitory and fibroblast proliferation accelerating effects of noroleanane- and oleanane-type triterpene oligoglycosides from the flower buds of Camellia japonica.
Topics: Animals; Camellia; Fibroblasts; Flowers; Humans; Melanins; Melanoma, Experimental; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Republic of Korea; Saponins; Skin | 2012 |
Anti-inflammatory properties of a triterpenoidal glycoside from Momordica cochinchinensis in LPS-stimulated macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromatography, Gas; Glycosides; Interleukin-6; Lipopolysaccharides; Macrophages; Magnetic Resonance Spectroscopy; Mice; Momordica; NF-kappa B; Nitric Oxide; Oleanolic Acid; Plant Extracts; Saponins; Seeds; Terpenes; Triterpenes | 2013 |
[Immune state in lung of BALB/c mice with ovalbumin allergy and the effects of fulvotomentoside on lungs of mice].
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drugs, Chinese Herbal; Female; Food Hypersensitivity; Immunohistochemistry; Inflammation; Interleukin-17; Interleukin-6; Lung Diseases; Mice; Mice, Inbred BALB C; Neutrophils; Oleanolic Acid; Ovalbumin; Saponins; Transforming Growth Factor beta1 | 2012 |
Oleanane saponins from Bellis sylvestris Cyr. and evaluation of their phytotoxicity on Aegilops geniculata Roth.
Topics: Asteraceae; Dose-Response Relationship, Drug; Molecular Conformation; Oleanolic Acid; Plant Leaves; Poaceae; Saponins; Stereoisomerism | 2012 |
Effect of saikosaponin A on maintenance of intravenous morphine self-administration.
Topics: Animals; Conditioning, Psychological; Drug Interactions; Infusions, Intravenous; Male; Morphine; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Saponins; Self Administration | 2012 |
[Impact of saikosaponin on absorption and transport of paeoniflorin in Caco-2 cell model].
Topics: Absorption; Benzoates; Biological Transport; Bridged-Ring Compounds; Caco-2 Cells; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Glucosides; Humans; Monoterpenes; Oleanolic Acid; Saponins | 2012 |
Determination of esculentoside A in dog plasma by LC-MS/MS method: application to pre-clinical pharmacokinetics.
Topics: Animals; Chromatography, Liquid; Dogs; Ginsenosides; Liquid-Liquid Extraction; Oleanolic Acid; Reference Standards; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyze sapogenin 3-O-glucosylation in saponin-mediated insect resistance.
Topics: Animals; Barbarea; Biocatalysis; Gene Expression; Gene Expression Regulation, Plant; Gene Library; Glucosyltransferases; Glycosylation; Herbivory; Insecta; Kinetics; Oleanolic Acid; Organ Specificity; Phylogeny; Plant Leaves; Sapogenins; Saponins; Substrate Specificity; Uridine Diphosphate | 2012 |
Synthesis of novel diosgenyl saponin analogues and apoptosis-inducing activity on A549 human lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Caspase 8; Caspase 9; Cell Line, Tumor; DNA Fragmentation; Glycosylation; Humans; Lung; Lung Neoplasms; Oleanolic Acid; Saponins | 2012 |
Kalopanaxsaponin B inhibits LPS-induced inflammation by inhibiting IRAK1 Kinase.
Topics: Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Drugs, Chinese Herbal; Enzyme Activation; I-kappa B Kinase; Inflammation; Interleukin-1 Receptor-Associated Kinases; Interleukin-1beta; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Microscopy, Confocal; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Oleanolic Acid; RNA Interference; Saponins; Toll-Like Receptor 4; Transfection; Tumor Necrosis Factor-alpha | 2012 |
Antithrombotic effect of chikusetsusaponin IVa isolated from Ilex paraguariensis (Maté).
Topics: Animals; Bleeding Time; Blood Coagulation; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Hemostasis; Humans; Ilex paraguariensis; Linear Models; Male; Oleanolic Acid; Partial Thromboplastin Time; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Saponins; Thrombin; Thrombin Time | 2012 |
Saikosaponin a mediates the anticonvulsant properties in the HNC models of AE and SE by inhibiting NMDA receptor current and persistent sodium current.
Topics: Animals; Anticonvulsants; Cells, Cultured; Electrophysiology; Epilepsy; Hippocampus; Neurons; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Saponins; Sodium; Status Epilepticus | 2012 |
Genetic and chemical analysis of a key biosynthetic step for soyasapogenol A, an aglycone of group A saponins that influence soymilk flavor.
Topics: Alleles; Chromosome Mapping; Chromosomes, Plant; Gene Deletion; Genes, Recessive; Genetic Loci; Glycine max; Microsatellite Repeats; Oleanolic Acid; Saponins; Soy Milk; Taste | 2013 |
Participation of extracellular calcium in α-hederin-induced contractions of rat isolated stomach strips.
Topics: Animals; Calcium; Calcium Channel Blockers; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Oleanolic Acid; Rats; Rats, Wistar; Saponins; Stomach; Verapamil | 2013 |
Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds.
Topics: Administration, Oral; Animals; Bile; Biotransformation; Chromatography, Liquid; Drugs, Chinese Herbal; Feces; Hydrolysis; Injections, Intravenous; Intestines; Liver; Male; Molecular Structure; Oleanolic Acid; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Antiproliferative oleanane saponins from Dizygotheca elegantissima.
Topics: Antineoplastic Agents, Phytogenic; Araliaceae; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oleanolic Acid; Saponins | 2012 |
Effects of saikosaponin-d on syndecan-2, matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in rats with hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Matrix Metalloproteinases; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Syndecan-2; Tissue Inhibitor of Metalloproteinase-2 | 2012 |
Determination of soyasaponins I and βg in raw and cooked legumes by solid phase extraction (SPE) coupled to liquid chromatography (LC)-mass spectrometry (MS) and assessment of their bioaccessibility by an in vitro digestion model.
Topics: Biological Availability; Chromatography, High Pressure Liquid; Digestion; Fabaceae; Humans; Mass Spectrometry; Oleanolic Acid; Saponins; Solid Phase Extraction | 2013 |
[Structure of secondary saikosaponins in saiko decoction].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Mass Spectrometry; Molecular Structure; Oleanolic Acid; Saponins | 2012 |
Osteoclast-inhibiting saikosaponin derivatives from Bupleurum chinense.
Topics: Animals; Bupleurum; Cells, Cultured; Drug Evaluation, Preclinical; Mice; Mice, Inbred C57BL; Molecular Structure; Oleanolic Acid; Osteoclasts; Plant Extracts; Plants, Medicinal; Saponins | 2013 |
Echinocystic acid, a metabolite of lancemaside A, inhibits TNBS-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Codonopsis; Colitis; Colon; Cytokines; Humans; Inflammation Mediators; Lipopolysaccharides; Macrophages, Peritoneal; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Protein Binding; Rhizome; Saponins; Signal Transduction; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2013 |
Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast.
Topics: Biosynthetic Pathways; Gene Expression Regulation, Plant; Genes, Plant; Medicago truncatula; Metabolic Engineering; Oleanolic Acid; Phylogeny; Saccharomyces cerevisiae; Saponins; Triterpenes | 2013 |
Multiscale study on the interaction mechanism between ginsenoside biosurfactant and saikosaponin a.
Topics: Computer Simulation; Ginsenosides; Light; Micelles; Microscopy, Electron, Transmission; Oleanolic Acid; Saponins; Scattering, Radiation; Surface-Active Agents; Unilamellar Liposomes | 2013 |
Inhibitory effects of oleanane-type triterpenes and saponins from the stem bark of Kalopanax pictus on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.
Topics: Animals; Bone Marrow; Cells, Cultured; Cytokines; Dendritic Cells; Inflammation Mediators; Kalopanax; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Oleanolic Acid; Plant Bark; Plant Extracts; Saponins | 2013 |
Real-time analysis of membrane permeabilizing effects of oleanane saponins.
Topics: Cell Line, Tumor; Cell Membrane; Cell Membrane Permeability; Electrophoresis; Humans; Oleanolic Acid; Saponins | 2013 |
Determination of Raddeanin A in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
Topics: Anemone; Animals; Chromatography, Liquid; Limit of Detection; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Tandem Mass Spectrometry | 2013 |
Oleanane-type triterpenoid saponins from the roots of Pulsatilla koreana and their apoptosis-inducing effects on HL-60 human promyelocytic leukemia cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia, Promyelocytic, Acute; Oleanolic Acid; Plant Extracts; Plant Roots; Pulsatilla; Saponins; Spectrum Analysis | 2013 |
Inhibitory effect of echinocystic acid on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Dermatitis; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Structure; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization; Tetradecanoylphorbol Acetate | 2014 |
Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells.
Topics: Animals; Cell Line; Cell Proliferation; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Roots; Platycodon; Rats; Saponins; Triterpenes | 2012 |
Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin.
Topics: Cell Line, Tumor; Cell Membrane; Cell Membrane Permeability; Cholesterol; Humans; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membrane Potentials; Microscopy, Fluorescence; Models, Chemical; Monocytes; Oleanolic Acid; Saponins; Sterols; Temperature; Time Factors | 2013 |
Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Molecular Conformation; Oleanolic Acid; Saponins; Structure-Activity Relationship; Triterpenes | 2013 |
Cytotoxic activity of Pulsatilla chinensis saponins and their structure-activity relationship.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Pulsatilla; Saponins; Stereoisomerism; Structure-Activity Relationship; Triterpenes | 2013 |
Neuroprotective effects of total saikosaponins of Bupleurum yinchowense on corticosterone-induced apoptosis in PC12 cells.
Topics: Animals; Apoptosis; Bupleurum; Calcium; Caspase 3; Cell Survival; Corticosterone; Endoplasmic Reticulum Stress; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitochondria; Neuroprotective Agents; Oleanolic Acid; PC12 Cells; Rats; Saponins; Sincalide | 2013 |
[Research on quality standards of zhuang medicine Lonicerae dasystylae flos].
Topics: Chlorogenic Acid; Chromatography, Thin Layer; Drugs, Chinese Herbal; Lonicera; Oleanolic Acid; Quality Control; Saponins; Solubility | 2013 |
Protective effect of esculentoside A on lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drugs, Chinese Herbal; I-kappa B Proteins; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-KappaB Inhibitor alpha; Oleanolic Acid; Pulmonary Edema; Saponins | 2013 |
Oleanane-type saponins from Anemone taipaiensis and their cytotoxic activities.
Topics: Anemone; Antineoplastic Agents, Phytogenic; HeLa Cells; Hep G2 Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Oleanolic Acid; Phytotherapy; Plant Extracts; Rhizome; Saponins | 2013 |
Triterpene saponins from Tabellae Clinopodii.
Topics: Antineoplastic Agents, Phytogenic; HeLa Cells; Humans; Lamiaceae; MCF-7 Cells; Molecular Structure; Neoplasms; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Saponins | 2013 |
Determination of chikusetsusaponin V and chikusetsusaponin IV in rat plasma by liquid chromatography-mass spectrometry and its application to a preliminary pharmacokinetic study.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Limit of Detection; Male; Oleanolic Acid; Panax; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Qualitative characterization of Desmodium adscendens constituents by high-performance liquid chromatography-diode array ultraviolet-electrospray ionization multistage mass spectrometry.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Fabaceae; Oleanolic Acid; Plant Extracts; Saponins; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2013 |
Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells.
Topics: Adenylate Kinase; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Beclin-1; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Tumor; Class III Phosphatidylinositol 3-Kinases; Membrane Proteins; Mice; Models, Molecular; Oleanolic Acid; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin-Activating Enzymes; Unfolded Protein Response | 2013 |
A new triterpenoid saponin from Ardisia gigantifolia.
Topics: Antineoplastic Agents, Phytogenic; Ardisia; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Rhizome; Saponins | 2013 |
Echinocystic acid isolated from Eclipta prostrata suppresses lipopolysaccharide-induced iNOS, TNF-α, and IL-6 expressions via NF-κB inactivation in RAW 264.7 macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Down-Regulation; Eclipta; Gene Expression Regulation; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Oleanolic Acid; Plants, Medicinal; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2013 |
[Chemical constituents from the root of Ilex cornuta].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ethanol; Ilex; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Roots; Saponins; Triterpenes | 2013 |
Saikosaponin A of Bupleurum chinense (Chaihu) elevates bone morphogenetic protein 4 (BMP-4) during hepatic stellate cell activation.
Topics: Actins; Animals; bcl-2-Associated X Protein; Bone Morphogenetic Protein 4; Bupleurum; Cattle; Cell Line; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Oleanolic Acid; Phytotherapy; RNA, Messenger; Saponins | 2013 |
Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis.
Topics: Anemone; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Rhizome; Saponins; Spectrometry, Mass, Electrospray Ionization | 2013 |
Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hepatocytes; Humans; Mitochondria; Molecular Structure; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Receptors, Platelet-Derived Growth Factor; Saponins; Structure-Activity Relationship | 2013 |
[Study on preparation and optimization of saikoside liposomes].
Topics: Bupleurum; Cholesterol; Citric Acid; Drug Carriers; Liposomes; Oleanolic Acid; Particle Size; Phospholipids; Plant Roots; Resins, Synthetic; Saponins | 2013 |
Changes in Heligmosomoides polygyrus glycoprotein pattern by saponins impact the BALB/c mice immune response.
Topics: Animals; Antigens, Helminth; Cytokines; Glucuronides; Glycoproteins; Glycosylation; Immune Sera; Immunoglobulin G; Larva; Male; Mice; Mice, Inbred BALB C; Nematospiroides dubius; Oleanolic Acid; Plant Extracts; Saponins; Strongylida Infections; Tagetes | 2013 |
Saikosaponin a and saikosaponin d inhibit proliferation and migratory activity of rat HSC-T6 cells.
Topics: Animals; Becaplermin; Bupleurum; Cell Movement; Cell Proliferation; Drugs, Chinese Herbal; Growth Inhibitors; Hepatic Stellate Cells; MAP Kinase Signaling System; Oleanolic Acid; Proto-Oncogene Proteins c-sis; Rats; Receptors, Transforming Growth Factor beta; Saponins; Transforming Growth Factor beta1 | 2013 |
Effects of saikosaponin A on cocaine self-administration in rats.
Topics: Animals; Bicuculline; Cocaine; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Morpholines; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Saponins; Self Administration | 2013 |
Saikosaponin-d increases the radiosensitivity of smmc-7721 hepatocellular carcinoma cells by adjusting the g0/g1 and g2/m checkpoints of the cell cycle.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Liver Neoplasms; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; RNA, Messenger; Saponins; Tumor Suppressor Protein p53; X-Rays | 2013 |
New triterpenoid saponins from the flowers of Pueraria thomsonii.
Topics: Drugs, Chinese Herbal; Flowers; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pueraria; Saponins | 2013 |
[Expression analysis of glycosyltransferase BcUGT1 from Bupleurum chinense DC. and its expression in E. coli and the target protein purification].
Topics: Amino Acid Sequence; Base Sequence; Bupleurum; Cloning, Molecular; DNA, Complementary; DNA, Plant; Escherichia coli; Genetic Vectors; Glycosyltransferases; Oleanolic Acid; Open Reading Frames; Phylogeny; Plants, Medicinal; Protein Structure, Secondary; Recombinant Fusion Proteins; Saponins | 2013 |
Effect of corchorusin-D, a saikosaponin like compound, on B16F10 melanoma cells (in vitro and in vivo).
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Corchorus; Glycosides; Humans; Melanoma; Membrane Potential, Mitochondrial; Mice; Mitochondria; Molecular Structure; Oleanolic Acid; Saponins; Skin Neoplasms; Triterpenes | 2013 |
A new oleanane-type triterpenoidal saponin from Pulsatilla chinensis.
Topics: Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Oleanolic Acid; Pulsatilla; Saponins; Spectrometry, Mass, Electrospray Ionization | 2013 |
Ardipusilloside I induces apoptosis by regulating Bcl-2 family proteins in human mucoepidermoid carcinoma Mc3 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Ardisia; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Down-Regulation; Humans; Oleanolic Acid; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Saponins | 2013 |
Saponins with highly hydroxylated oleanane-type aglycones from Silphium asteriscus L.
Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Jurkat Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins | 2014 |
Validated rapid resolution LC-ESI-MS/MS method for simultaneous determination of five pulchinenosides from Pulsatilla chinensis (Bunge) Regel in rat plasma: application to pharmacokinetics and bioavailability studies.
Topics: Administration, Intravenous; Administration, Oral; Animals; Chromatography, Liquid; Male; Oleanolic Acid; Plant Extracts; Pulsatilla; Rats; Rats, Wistar; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Soyasaponin I improved neuroprotection and regeneration in memory deficient model rats.
Topics: Animals; Behavior, Animal; Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Hippocampus; Ibotenic Acid; Male; Memory; Memory Disorders; Microglia; Nerve Regeneration; Neural Stem Cells; Neurons; Neuroprotective Agents; Oleanolic Acid; Pregnancy; Rats; Rats, Sprague-Dawley; Saponins | 2013 |
Glycosylated platycosides: identification by enzymatic hydrolysis and structural determination by LC-MS/MS.
Topics: Biocatalysis; Cellulases; Chromatography, High Pressure Liquid; Fabaceae; Fungal Proteins; Molecular Structure; Oleanolic Acid; Plant Extracts; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichoderma | 2014 |
Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential.
Topics: Caulophyllum; Cell Respiration; Dietary Supplements; Dose-Response Relationship, Drug; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Oleanolic Acid; Phytotherapy; Saponins; United States | 2014 |
Facile synthesis of the naturally cytotoxic triterpenoid saponin Patrinia-glycoside B-II and its conformer.
Topics: Cell Line, Tumor; Cell Proliferation; Combinatorial Chemistry Techniques; Glycosides; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Molecular Structure; Oleanolic Acid; Patrinia; Saponins; Triterpenes | 2013 |
[Study on constituents of the aerial parts of Pogostemon cablin].
Topics: Cholestenones; Dibutyl Phthalate; Lamiaceae; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Saponins; Stigmasterol | 2013 |
Acylated oleanane-type saponins from Ganophyllum giganteum.
Topics: Acylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hydrolysis; Inflammation; Mice; Molecular Conformation; Oleanolic Acid; Plant Roots; Sapindaceae; Saponins; Structure-Activity Relationship | 2014 |
Saikosaponin-D enhances radiosensitivity of hepatoma cells under hypoxic conditions by inhibiting hypoxia-inducible factor-1α.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Radiation Tolerance; Saponins; Tumor Stem Cell Assay; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2014 |
Three new olean-type triterpenoid saponins from aerial parts of Eclipta prostrata (L.).
Topics: Drugs, Chinese Herbal; Eclipta; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins | 2014 |
New triterpenoid saponins from the aerial parts of Schefflera kwangsiensis.
Topics: Araliaceae; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Components, Aerial; Saponins; Triterpenes | 2014 |
Chemical fingerprinting and quantitative analysis of two common Gleditsia sinensis fruits using HPLC-DAD.
Topics: Chromatography, High Pressure Liquid; Fruit; Gleditsia; Oleanolic Acid; Saponins | 2013 |
New oleanane-type triterpenoid saponins isolated from the seeds of Celosia argentea.
Topics: Celosia; Drugs, Chinese Herbal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Seeds; Stereoisomerism | 2014 |
Cytotoxic oleanane-type triterpenoid saponins from the Rhizomes of Anemone rivularis var. flore-minore.
Topics: Anemone; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; Oleanolic Acid; Plant Extracts; Rhizome; Saponins; Triterpenes | 2014 |
Pharmacokinetic study of calenduloside E and its active metabolite oleanolic acid in beagle dog using liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Dogs; Female; Least-Squares Analysis; Limit of Detection; Male; Oleanolic Acid; Reproducibility of Results; Saponins; Tandem Mass Spectrometry | 2014 |
Saikosaponin C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bupleurum; Caspase 3; Focal Adhesion Protein-Tyrosine Kinases; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; Oleanolic Acid; Saponins | 2014 |
The haploinsufficiency profile of α-hederin suggests a caspofungin-like antifungal mode of action.
Topics: Antifungal Agents; Caspofungin; Echinocandins; Gene Deletion; Haploinsufficiency; Hedera; Lipopeptides; Oleanolic Acid; Plant Extracts; Plant Leaves; Saccharomyces cerevisiae; Saponins | 2014 |
The apoptotic effect of D Rhamnose β-hederin, a novel oleanane-type triterpenoid saponin on breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; Breast Neoplasms; Caspase 3; Caspase 9; Chromones; Cytochromes c; Drug Screening Assays, Antitumor; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Female; Humans; MAP Kinase Signaling System; MCF-7 Cells; Membrane Potential, Mitochondrial; Morpholines; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Saponins | 2014 |
Pharmacokinetics study of asperosaponin VI and its metabolites cauloside A, HN saponin F and hederagenin.
Topics: Animals; Chromatography, High Pressure Liquid; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Isolation of an oleanane-type saponin active from Bellis perennis through antitumor bioassay-guided procedures.
Topics: Agrobacterium tumefaciens; Antineoplastic Agents, Phytogenic; Asteraceae; Oleanolic Acid; Plant Extracts; Saponins; Solanum tuberosum | 2014 |
Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway.
Topics: Analysis of Variance; Animals; Annexin A5; Anti-Inflammatory Agents; Apoptosis; Calcium; Cell Survival; Corticosterone; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oleanolic Acid; PC12 Cells; Propidium; Rats; Receptors, Glucocorticoid; Saponins; Signal Transduction | 2014 |
Effect of saikosaponins and extracts of vinegar-baked Bupleuri Radix on the activity of β-glucuronidase.
Topics: 1-Butanol; Acetic Acid; Bupleurum; Drugs, Chinese Herbal; Glucuronates; Glucuronidase; Liver; Nitrophenols; Oleanolic Acid; Saponins | 2014 |
Domain formation and permeabilization induced by the saponin α-hederin and its aglycone hederagenin in a cholesterol-containing bilayer.
Topics: Cholesterol; Lipid Bilayers; Membrane Microdomains; Oleanolic Acid; Saponins | 2014 |
Comparison of bioavailability (I) between soyasaponins and soyasapogenols, and (II) between group A and B soyasaponins.
Topics: Animals; Caco-2 Cells; Humans; Intestinal Absorption; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 2014 |
Triterpenoid saponin biosynthetic pathway profiling and candidate gene mining of the Ilex asprella root using RNA-Seq.
Topics: Base Sequence; Biosynthetic Pathways; Data Mining; Databases, Genetic; Drugs, Chinese Herbal; Erythritol; Gene Expression; Gene Expression Profiling; Genes, Plant; Ilex; Mevalonic Acid; Oleanolic Acid; Phylogeny; Plant Extracts; Plant Roots; Saponins; Sequence Analysis, DNA; Sequence Analysis, RNA; Squalene; Transcriptome; Triterpenes | 2014 |
Saikosaponin‑d inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; G1 Phase Cell Cycle Checkpoints; Humans; Male; Membrane Potential, Mitochondrial; Oleanolic Acid; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Tumor Suppressor Protein p53; Up-Regulation | 2014 |
Determination of asperosaponin VI and its active metabolite hederagenin in rat tissues by LC-MS/MS: application to a tissue distribution study.
Topics: Animals; Chromatography, High Pressure Liquid; Dipsacaceae; Drugs, Chinese Herbal; Female; Liver; Lung; Male; Oleanolic Acid; Ovary; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Tissue Distribution | 2014 |
Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro.
Topics: Acetic Acid; Animals; Bupleurum; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Herb-Drug Interactions; Isoenzymes; Male; Mice; Microsomes, Liver; Oleanolic Acid; Plant Extracts; Saponins; Time Factors | 2014 |
A new triterpenoid saponin and an oligosaccharide isolated from the fruits of Sapindus mukorossi.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Fruit; Humans; Male; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Oligosaccharides; Sapindus; Saponins; Triterpenes | 2014 |
The anticancer effect and mechanism of α-hederin on breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Clematis; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Oleanolic Acid; Phytotherapy; Plant Extracts; Saponins | 2014 |
Triterpene saponins from the stems of Entada phaseoloides.
Topics: Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Fabaceae; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Stems; Saponins; Triterpenes | 2014 |
Cytotoxic effects of four Caryophyllaceae species extracts on macrophage cell lines.
Topics: Animals; Apoptosis; Caryophyllaceae; Caspase 3; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Glucuronides; Humans; Macrophages; Methanol; Monocytes; Oleanolic Acid; Plant Extracts; Plant Roots; Rats; Saponins | 2014 |
Cell type-specific qualitative and quantitative analysis of saikosaponins in three Bupleurum species using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Lasers; Mass Spectrometry; Microdissection; Oleanolic Acid; Plant Structures; Saponins | 2014 |
Fragment ion diagnostic strategies for the comprehensive identification of chemical profile of Gui-Zhi-Tang by integrating high-resolution MS, multiple-stage MS and UV information.
Topics: Chromatography, Liquid; Cinnamomum aromaticum; Drugs, Chinese Herbal; Flavones; Flavonoids; Isoflavones; Mass Spectrometry; Oleanolic Acid; Plant Extracts; Saponins; Triterpenes; Ultraviolet Rays | 2014 |
Investigation of triterpene synthesis and regulation in oats reveals a role for β-amyrin in determining root epidermal cell patterning.
Topics: Avena; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Plant; Glucuronidase; Green Fluorescent Proteins; Intramolecular Transferases; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Oleanolic Acid; Phylogeny; Plant Epidermis; Plant Proteins; Plant Roots; Plants, Genetically Modified; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Transcriptome; Triterpenes | 2014 |
Uralsaponins M-Y, antiviral triterpenoid saponins from the roots of Glycyrrhiza uralensis.
Topics: Animals; Anti-HIV Agents; Antiviral Agents; Dogs; Drugs, Chinese Herbal; Glycyrrhiza uralensis; Humans; Influenza A Virus, H1N1 Subtype; Madin Darby Canine Kidney Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Oseltamivir; Plant Roots; Saponins | 2014 |
Stimulation of autophagic activity in human glioma cells by anti-proliferative ardipusilloside I isolated from Ardisia pusilla.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Ardisia; Autophagy; Beclin-1; Brain Neoplasms; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chloroquine; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioma; Humans; Membrane Proteins; Oleanolic Acid; Saponins | 2014 |
Theasaponin E₁ as an effective ingredient for anti-angiogenesis and anti-obesity effects.
Topics: Adipogenesis; Angiogenesis Inhibitors; Animals; Anti-Obesity Agents; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Mice; Oleanolic Acid; RNA, Messenger; Saponins; Xenograft Model Antitumor Assays | 2014 |
A rapid and sensitive LC-MS/MS method for the determination of Pulsatilla saponin D in rat plasma and its application in a rat pharmacokinetic and bioavailability study.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Chemical Precipitation; Chromatography, High Pressure Liquid; Drug Stability; Male; Oleanolic Acid; Pulsatilla; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Tandem Mass Spectrometry; United States; United States Food and Drug Administration | 2015 |
Effects of SSd combined with radiation on inhibiting SMMC-7721 hepatoma cell growth.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; In Vitro Techniques; Liver Neoplasms; Microscopy, Electron, Transmission; Oleanolic Acid; Radiation-Sensitizing Agents; Saponins; Tetrazolium Salts; Thiazoles | 2014 |
[Study on quality control method of suanzaoren hehuan formula and fingerprint of its saponins parts].
Topics: Antidepressive Agents; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucosides; Monoterpenes; Oleanolic Acid; Plants, Medicinal; Quality Control; Reproducibility of Results; Saponins; Spectrophotometry, Ultraviolet | 2014 |
Attenuation of neuropathic pain by saikosaponin a in a rat model of chronic constriction injury.
Topics: Animals; Chronic Disease; Constriction; Disease Models, Animal; Male; Neuralgia; NF-kappa B; Oleanolic Acid; Rats, Sprague-Dawley; Saponins; Sciatic Nerve; Spinal Cord; Tumor Necrosis Factor-alpha | 2014 |
Identification of marker compounds for Japanese Pharmacopoeia non-conforming jujube seeds from Myanmar.
Topics: Biomarkers; China; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Japan; Myanmar; Oleanolic Acid; Peptides, Cyclic; Pharmacopoeias as Topic; Plant Extracts; Saponins; Seeds; Ziziphus | 2015 |
Saikosaponin-D attenuates heat stress-induced oxidative damage in LLC-PK1 cells by increasing the expression of anti-oxidant enzymes and HSP72.
Topics: Animals; Bupleurum; Catalase; Dose-Response Relationship, Drug; Glutathione Peroxidase; Heat-Shock Response; Hot Temperature; HSP72 Heat-Shock Proteins; LLC-PK1 Cells; Malondialdehyde; Oleanolic Acid; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Saponins; Superoxide Dismutase; Swine | 2014 |
Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4.
Topics: Alkaloids; Animals; Apoptosis Regulatory Proteins; Guanidine; HEK293 Cells; Humans; Oleanolic Acid; Porifera; RNA-Binding Proteins; Saponins; Tumor Suppressor Proteins | 2014 |
Saikosaponin‑d suppresses the expression of cyclooxygenase‑2 through the phospho‑signal transducer and activator of transcription 3/hypoxia‑inducible factor‑1α pathway in hepatocellular carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Cyclooxygenase 2; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Oleanolic Acid; Phosphorylation; Protein Processing, Post-Translational; Saponins; STAT3 Transcription Factor | 2014 |
Soyasaponins can blunt inflammation by inhibiting the reactive oxygen species-mediated activation of PI3K/Akt/NF-kB pathway.
Topics: Animals; Cell Line; Chromones; Cyclooxygenase 2; Dinoprostone; Glycine max; I-kappa B Kinase; Inflammation; Lipopolysaccharides; Macrophages; Malondialdehyde; Mice; Morpholines; Nitriles; Oleanolic Acid; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Saponins; Signal Transduction; Sulfones; Superoxide Dismutase; Transcription Factor RelA | 2014 |
A systematic study on the influence of the main ingredients of an ivy leaves dry extract on the β2-adrenergic responsiveness of human airway smooth muscle cells.
Topics: Chromatography, High Pressure Liquid; Cyclic AMP; Dose-Response Relationship, Drug; Flavonoids; Hedera; HEK293 Cells; Humans; Hydroxybenzoates; Mass Spectrometry; Myocytes, Smooth Muscle; Oleanolic Acid; Plant Extracts; Plant Leaves; Receptors, Adrenergic, beta-2; Saponins | 2015 |
Hepatoprotective saikosaponin homologs from Comastoma pedunculatum.
Topics: Cell Line, Tumor; Cytostatic Agents; Gentianaceae; Humans; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Protective Agents; Saponins; Triterpenes | 2014 |
[Preparation of triterpene saponins from Platycodon grandiflorum by two-dimensional hydrophilic interaction liquid chromatography-reversed phase liquid chromatography].
Topics: Chromatography, Liquid; Chromatography, Reverse-Phase; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Oleanolic Acid; Platycodon; Saponins; Triterpenes | 2014 |
Simultaneous quantification of Akebia saponin D and its five metabolites in human intestinal bacteria using ultra-performance liquid chromatography triple quadrupole mass spectrometry.
Topics: Bacteria; Chromatography, High Pressure Liquid; Feces; Humans; Intestines; Mass Spectrometry; Oleanolic Acid; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2014 |
Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Bupleurum; Chemical and Drug Induced Liver Injury; Cytokines; Down-Regulation; Drugs, Chinese Herbal; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Oxidative Stress; Plants, Medicinal; PPAR alpha; RNA, Messenger; Saponins; Signal Transduction; STAT3 Transcription Factor | 2014 |
Anthelmintic activity of saikosaponins a and d from radix bupleuri against Dactylogyrus spp. infecting goldfish.
Topics: Animals; Anthelmintics; Bupleurum; Fish Diseases; Goldfish; Helminthiasis, Animal; Molecular Structure; Oleanolic Acid; Plant Roots; Platyhelminths; Saponins | 2014 |
Saikosaponin-d inhibits proliferation of human undifferentiated thyroid carcinoma cells through induction of apoptosis and cell cycle arrest.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Male; Mice; Mice, Nude; Oleanolic Acid; Saponins; Thyroid Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Shu‑Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint.
Topics: Animals; Body Mass Index; Depression; Drugs, Chinese Herbal; Female; Fluoxetine; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Medicine, Chinese Traditional; Oleanolic Acid; Premenstrual Syndrome; Rats; Rats, Wistar; Saponins | 2014 |
Antimicrobial steroidal saponin and oleanane-type triterpenoid saponins from Paullinia pinnata.
Topics: Anti-Infective Agents; Bacteria; Fungi; Microbial Sensitivity Tests; Oleanolic Acid; Paullinia; Plant Extracts; Saponins | 2014 |
Bioactive constituents of oleanane-type triterpene saponins from the roots of Glycyrrhiza glabra.
Topics: Antioxidants; Glycyrrhiza; Molecular Structure; Neuraminidase; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Saponins; Structure-Activity Relationship | 2014 |
The protective effect of Esculentoside A on experimental acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Saponins; Signal Transduction; Sincalide | 2014 |
New triterpenoid saponins from the aerial parts of Comastomapedunculatum.
Topics: Araliaceae; Drugs, Chinese Herbal; Molecular Structure; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Components, Aerial; Saponins | 2015 |
Pharmacological experimental study of the anti-depressant effect of total saikosaponins.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Hindlimb Suspension; Humans; Male; Mice; Motor Activity; Oleanolic Acid; Saponins | 2014 |
Triterpene glycosides and other polar constituents of shea (Vitellaria paradoxa) kernels and their bioactivities.
Topics: alpha-MSH; Animals; Antigens, Viral; Biphenyl Compounds; Glycosides; HL-60 Cells; Humans; Melanins; Mice; Molecular Structure; Monophenol Monooxygenase; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Oxidoreductases; Picrates; Saponins; Sapotaceae; Seeds; Triterpenes | 2014 |
Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.
Topics: Animals; Antiviral Agents; Bupleurum; Cell Line; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Liver Transplantation; Male; Oleanolic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins; Virion; Virus Internalization; Virus Replication | 2015 |
Comparative analysis of CYP93E proteins for improved microbial synthesis of plant triterpenoids.
Topics: Cytochrome P-450 Enzyme System; Medicago truncatula; Oleanolic Acid; Saccharomyces cerevisiae; Saponins; Triterpenes | 2014 |
Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion.
Topics: Bupleurum; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Survival; Endothelial Cells; Gene Expression; Humans; Immunophenotyping; Molecular Structure; Monocytes; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Selectins; Tumor Necrosis Factor-alpha | 2014 |
Two new triterpenoid saponins from rhizome of Anemone amurensis.
Topics: Anemone; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Rhizome; Saponins | 2015 |
Biotransformation on the triterpenoid saponin of Ardisia gigantifolia by Aspergillus avenaceus AS 3.4454.
Topics: Antineoplastic Agents, Phytogenic; Ardisia; Aspergillus; Biotransformation; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Triterpenes | 2015 |
Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves.
Topics: Anti-Ulcer Agents; Apigenin; Brazil; Glycosides; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Sapindaceae; Saponins; Triterpenes | 2015 |
Triterpene saponins from Eryngium kotschyi.
Topics: Eryngium; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Saponins; Stereoisomerism; Turkey | 2015 |
Antiproliferative quillaic acid and gypsogenin saponins from Saponaria officinalis L. roots.
Topics: Animals; Antineoplastic Agents, Phytogenic; Caryophyllaceae; Humans; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Saponaria; Saponins; Sheep; Triterpenes | 2015 |
Effects of soyasaponin I and soyasaponins-rich extract on the alternariol-induced cytotoxicity on Caco-2 cells.
Topics: Alternaria; Antioxidants; Caco-2 Cells; Cell Proliferation; Cell Survival; Cytoprotection; DNA Damage; Drug Synergism; Humans; Lactones; Lens Plant; Mycotoxins; Oleanolic Acid; Plant Extracts; Saponins | 2015 |
Separation and identification of multiple constituents in Xiao Chai Hu Decoction (Sho-saiko-to) by bioactivity-guided fractionation combined with LC-ESI-QTOFMS/MS.
Topics: Bupleurum; Catechols; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fatty Alcohols; Flavonoids; Ginsenosides; Oleanolic Acid; Plant Extracts; Polysaccharides; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
[Accumulation dynamic of triterpenoid saponins in Akebia trifoliata stem].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Magnoliopsida; Oleanolic Acid; Plant Stems; Saponins | 2014 |
Development and validation of a HPLC-MS/MS method for the determination of phytolaccagenin in rat plasma and application to a pharmacokinetic study.
Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Half-Life; Male; Oleanolic Acid; Phytolacca americana; Plant Extracts; Plant Roots; Plasma; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways.
Topics: Animals; Bone Marrow Cells; Bupleurum; Cell Differentiation; Cell Line; Humans; Immunosuppressive Agents; Medicine, Chinese Traditional; Mice; Monocytes; NF-kappa B; Oleanolic Acid; Osteoclasts; Osteoporosis; p38 Mitogen-Activated Protein Kinases; RANK Ligand; Saponins; Signal Transduction | 2015 |
Chikusetsu Saponin IVa Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice via Adiponectin-Mediated AMPK/GSK-3β Pathway In Vivo and In Vitro.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Brain Ischemia; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oleanolic Acid; Reperfusion Injury; Saponins; Signal Transduction | 2016 |
Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE-/- mice.
Topics: Animals; Apolipoproteins E; Apoptosis; Aralia; Diet, High-Fat; Endoribonucleases; Liver; Male; MAP Kinase Kinase 4; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oleanolic Acid; Phytotherapy; Protein Serine-Threonine Kinases; Saponins; Signal Transduction | 2015 |
Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways.
Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents; Cytokines; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Inflammation; Inflammation Mediators; Mice; NF-kappa B; Nitric Oxide; Oleanolic Acid; Saponins; Signal Transduction | 2015 |
Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects.
Topics: Animals; Aralia; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids, Nonesterified; Glucose; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Oleanolic Acid; Oxidation-Reduction; Plant Bark; Plant Roots; Rats; Rats, Wistar; Saponins; Streptozocin; Triglycerides | 2015 |
Impact of soyasaponin I on TLR2 and TLR4 induced inflammation in the MUTZ-3-cell model.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; B7-2 Antigen; Cell Line, Tumor; Cell Proliferation; Cell Shape; Chemokines; Cytokines; Endotoxins; Humans; Immunologic Factors; Leukemia, Myeloid, Acute; Monocytes; Neoplasm Proteins; Oleanolic Acid; Osmolar Concentration; Saponins; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2015 |
Chemical and biological comparison of raw and vinegar-baked Radix Bupleuri.
Topics: Acetic Acid; Animals; Bupleurum; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Female; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Oleanolic Acid; Plant Extracts; Saponins | 2015 |
Insulinotropic effect of Chikusetsu saponin IVa in diabetic rats and pancreatic β-cells.
Topics: Animals; Calcium; Cell Line; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Oleanolic Acid; Protein Kinase C; Rats, Wistar; Receptors, G-Protein-Coupled; Saponins | 2015 |
[Study on microwave processing technology of achyranthis bidentatae radix by orthogonal design].
Topics: Drugs, Chinese Herbal; Microwaves; Oleanolic Acid; Plant Roots; Saponins; Wine | 2014 |
Discovery of a potent anti-yeast triterpenoid saponin, clematoside-S from Urena lobata L.
Topics: Drug Discovery; Ethanol; Magnetic Resonance Spectroscopy; Malvaceae; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Leaves; Saccharomyces cerevisiae; Saponins; Triterpenes | 2015 |
Chikusetsusaponin IVa methyl ester induces cell cycle arrest by the inhibition of nuclear translocation of β-catenin in HCT116 cells.
Topics: Base Sequence; beta Catenin; Cell Cycle; Cell Line; Cell Nucleus; DNA Primers; Esters; Oleanolic Acid; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Saponins | 2015 |
The protective effect of α-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Bronchodilator Agents; Guinea Pigs; Histamine; Male; Methacholine Chloride; Nigella sativa; Oleanolic Acid; Ovalbumin; Plants, Medicinal; Pneumonia; Saponins; Trachea | 2015 |
Nerve growth factor promotes reorganization of the axonal microtubule array at sites of axon collateral branching.
Topics: Animals; Avian Proteins; Axons; Chick Embryo; Fluorescent Antibody Technique; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Nerve Growth Factor; Oleanolic Acid; Phosphorylation; Pseudopodia; Saponins; Sensory Receptor Cells; Transfection | 2015 |
Development of a method to screen and isolate potential α-glucosidase inhibitors from Panax japonicus C.A. Meyer by ultrafiltration, liquid chromatography, and counter-current chromatography.
Topics: Acetonitriles; alpha-Glucosidases; Chromatography, Liquid; Diabetes Mellitus; Enzyme Inhibitors; Formates; Ginsenosides; Glycoside Hydrolase Inhibitors; Humans; Ligands; Mass Spectrometry; Methyl Ethers; Models, Theoretical; Multivariate Analysis; Oleanolic Acid; Panax; Plant Extracts; Saponins; Solvents; Spectrometry, Mass, Electrospray Ionization; Ultrafiltration | 2015 |
[Effect of combined application of zinc, boron and molybdenum on yield and saikosaponin a, saikosaponin d contents of Bupleurum chinense].
Topics: Boron; Bupleurum; Fertilizers; Molybdenum; Oleanolic Acid; Plant Roots; Saponins; Trace Elements; Zinc | 2014 |
Formulations, hemolytic and pharmacokinetic studies on saikosaponin a and saikosaponin d compound liposomes.
Topics: Administration, Intravenous; Animals; Biological Availability; Chemistry, Pharmaceutical; Half-Life; Hemolysis; Hydrophobic and Hydrophilic Interactions; Liposomes; Molecular Structure; Oleanolic Acid; Particle Size; Rabbits; Saponins | 2015 |
[Influence of soil factors on quality of panacis majoris rhizoma].
Topics: Ginsenosides; Metals, Heavy; Oleanolic Acid; Rhizome; Saponins; Soil | 2014 |
Antifungal properties of a new terpernoid saponin and other compounds from the stem bark of Polyscias fulva Hiern (Araliaceae).
Topics: Antifungal Agents; Araliaceae; Arthrodermataceae; Oleanolic Acid; Plant Bark; Plant Extracts; Plant Stems; Saponins; Spores, Fungal; Terpenes; Yeasts | 2015 |
Novel triterpenoid saponins from residual seed cake of Camellia oleifera Abel. show anti-proliferative activity against tumor cells.
Topics: Antineoplastic Agents, Phytogenic; Camellia; Cell Line, Tumor; Humans; Molecular Structure; Oleanolic Acid; Saponins; Seeds; Triterpenes | 2015 |
Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Euphorbiaceae; Female; HT29 Cells; Humans; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Saponins; Vietnam | 2015 |
Two new triterpenoid saponins from the aerial parts of Anemone taipaiensis.
Topics: Anemone; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Oleanolic Acid; Plant Components, Aerial; Rhizome; Saponins | 2015 |
Oleanane-type triterpene saponins with collagen synthesis-promoting activity from the flowers of Bellis perennis.
Topics: Asteraceae; Collagen; Flowers; Humans; Japan; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Triterpenes | 2015 |
CYP72A67 Catalyzes a Key Oxidative Step in Medicago truncatula Hemolytic Saponin Biosynthesis.
Topics: Cytochrome P-450 Enzyme System; Gene Expression Regulation, Plant; Medicago truncatula; Oleanolic Acid; Plant Leaves; Plant Proteins; Plant Roots; Saponins; Triterpenes | 2015 |
[Study on Quality Standard for Panax japonicus Rhizome].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ginsenosides; Oleanolic Acid; Panax; Rhizome; Saponins | 2014 |
[Intestinal absorption of pulchinenosides from Pulsatilla chinensis in rats].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Intestinal Absorption; Male; Oleanolic Acid; Pulsatilla; Rats; Rats, Wistar; Saponins | 2015 |
Esculentoside A suppresses Aβ(1-42)-induced neuroinflammation by down-regulating MAPKs pathways in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Astrocytes; Disease Models, Animal; Down-Regulation; Encephalitis; Hippocampus; Inflammation Mediators; Male; MAP Kinase Signaling System; Memory; Mice; Mice, Inbred C57BL; Microglia; Oleanolic Acid; Peptide Fragments; Saponins | 2015 |
Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways.
Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Line; Cell Survival; Cisplatin; Cytokines; Humans; Kidney Diseases; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Reactive Oxygen Species; RNA, Messenger; Saponins; Signal Transduction | 2015 |
Deglucose chikusetsusaponin IVa isolated from Rhizoma Panacis Majoris induces apoptosis in human HepG2 hepatoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Oleanolic Acid; Saponins; Signal Transduction | 2015 |
Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Cyclooxygenase 2; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; MAP Kinase Signaling System; NF-kappa B; Nitric Oxide Synthase Type II; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Messenger; Saponins; Signal Transduction | 2015 |
Lactobacillus pentosus var. plantarum C29 increases the protective effect of soybean against scopolamine-induced memory impairment in mice.
Topics: Acetylcholinesterase; Animals; Brain-Derived Neurotrophic Factor; Fermentation; Gene Expression Regulation; Genistein; Glycine max; Hippocampus; Isoflavones; Lactobacillus plantarum; Male; Memory Disorders; Mice; Mice, Inbred ICR; Oleanolic Acid; Plant Preparations; Saponins; Scopolamine | 2015 |
Recognition and identification of active components from Radix Bupleuri using human neuroblastoma SH-SY5Y cells.
Topics: Cell Line, Tumor; Cell Membrane; Chromatography, Liquid; Drug Discovery; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Humans; Medicine, Chinese Traditional; Neuroblastoma; Oleanolic Acid; Plants, Medicinal; Psychotropic Drugs; Reproducibility of Results; Saponins | 2016 |
Oleanane-type Triterpene Saponins from Glochidion glomerulatum.
Topics: Magnoliopsida; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Leaves; Saponins | 2015 |
Synthesis and Evaluation of a Series of Oleanolic Acid Saponins as α-Glucosidase and α-Amylase Inhibitors.
Topics: Acarbose; alpha-Amylases; alpha-Glucosidases; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Design; Glycoside Hydrolase Inhibitors; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship | 2015 |
[Effects of Aphid Occurring on Lonicera macranthoides Bud Yield and Quality].
Topics: Animals; Aphids; Caffeic Acids; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavones; Glucosides; Herbivory; Lonicera; Luteolin; Oleanolic Acid; Saponins | 2015 |
Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethanol; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Plant Roots; Saponins | 2015 |
Cytotoxic triterpenoid glycosides (saikosaponins) from the roots of Bupleurum chinense.
Topics: Bupleurum; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Stereoisomerism; Structure-Activity Relationship | 2015 |
Inhibitory Activity of Yokukansankachimpihange against Nerve Growth Factor-Induced Neurite Growth in Cultured Rat Dorsal Root Ganglion Neurons.
Topics: Alkaloids; Animals; Bupleurum; Cell Death; Cells, Cultured; Drugs, Chinese Herbal; Ganglia, Spinal; Indole Alkaloids; Male; Nerve Growth Factor; Neurites; Oleanolic Acid; Oxindoles; Plant Extracts; Rats, Sprague-Dawley; Saponins; Uncaria | 2015 |
The Protective Effect of α-Hederin, the Active Constituent of Nigella sativa, on Lung Inflammation and Blood Cytokines in Ovalbumin Sensitized Guinea Pigs.
Topics: Animals; Benzoquinones; Cytokines; Drugs, Chinese Herbal; Fluticasone; Guinea Pigs; Interleukin-17; Interleukin-4; Lung; Male; Nigella sativa; Oleanolic Acid; Ovalbumin; Plant Extracts; Pneumonia; Saponins | 2015 |
Identification and genome organization of saponin pathway genes from a wild crucifer, and their use for transient production of saponins in Nicotiana benthamiana.
Topics: Barbarea; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Plant; Genome, Plant; Herbivory; Intramolecular Transferases; Nicotiana; Oleanolic Acid; Pentacyclic Triterpenes; Phylogeny; Plant Proteins; Plants, Genetically Modified; Quantitative Trait Loci; Sapogenins; Saponins; Triterpenes | 2015 |
LC-MS-based quantification method for Achyranthes root saponins.
Topics: Achyranthes; Chromatography, Liquid; Mass Spectrometry; Oleanolic Acid; Plant Roots; Saponins | 2016 |
Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts.
Topics: Anti-Inflammatory Agents; Blotting, Western; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Membrane Microdomains; Oleanolic Acid; Oxidative Stress; Protein Transport; Reactive Oxygen Species; RNA, Small Interfering; Saponins; Signal Transduction; Toll-Like Receptor 4; Transfection | 2015 |
Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway.
Topics: Active Transport, Cell Nucleus; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Cell Adhesion Molecules; Cell Line; Cytokines; Dexamethasone; Disease Models, Animal; Drugs, Chinese Herbal; Female; Heme Oxygenase-1; Humans; Immunoglobulin E; Lung; Membrane Proteins; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oleanolic Acid; Ovalbumin; RNA, Small Interfering; Saponins; Signal Transduction | 2015 |
A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze.
Topics: Animals; Blood Coagulation; In Vitro Techniques; Lamiaceae; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medicine, Chinese Traditional; Oleanolic Acid; Platelet Aggregation; Rabbits; Sapogenins; Saponins; Spectrometry, Mass, Electrospray Ionization; Thrombin Time; Triterpenes | 2016 |
Global Profiling of Various Metabolites in Platycodon grandiflorum by UPLC-QTOF/MS.
Topics: Mass Spectrometry; Metabolome; Oleanolic Acid; Plant Leaves; Plant Roots; Plant Stems; Platycodon; Saponins; Solvents; Triterpenes | 2015 |
Rapid Determination of α-Hederin and Hederacoside C in Extracts of Hedera helix Leaves Available in the Czech Republic and Poland.
Topics: Chromatography, High Pressure Liquid; Czech Republic; Hedera; Oleanolic Acid; Plant Extracts; Plant Leaves; Poland; Reproducibility of Results; Saponins | 2015 |
Ardipusilloside-I Metabolites from Human Intestinal Bacteria and Their Antitumor Activity.
Topics: Antineoplastic Agents; Bacteria; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Gastrointestinal Microbiome; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Extracts; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
Saikosaponin A inhibits influenza A virus replication and lung immunopathology.
Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunoblotting; Influenza A virus; Influenza, Human; Lung; Mice; Mice, Inbred C57BL; Oleanolic Acid; Orthomyxoviridae Infections; Respiratory Tract Infections; Saponins; Virus Replication | 2015 |
CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells.
Topics: Animals; Annexin A5; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Basigin; Chitosan; Endocytosis; Flow Cytometry; Fluorescence; Hep G2 Cells; Humans; Imaging, Three-Dimensional; Intracellular Space; Liver Neoplasms; Mice, Nude; Microscopy, Confocal; Nanoparticles; Oleanolic Acid; Particle Size; Propidium; Saponins; Spectroscopy, Fourier Transform Infrared; Spectroscopy, Near-Infrared; Subcellular Fractions | 2015 |
Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Bupleurum; Caspase 8; Cell Line; Chemical and Drug Induced Liver Injury; fas Receptor; Hepatocytes; Humans; Male; MAP Kinase Signaling System; Mice; Mitochondria; Oleanolic Acid; Saponins; Signal Transduction | 2016 |
Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway.
Topics: Animals; Apoptosis; Calcium; Cardiotonic Agents; Cardiotoxicity; Glucose; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myoblasts, Cardiac; Myocytes, Cardiac; Oleanolic Acid; Oxidative Stress; Rats; Reactive Oxygen Species; Saponins; Signal Transduction; Sirtuin 1 | 2015 |
Complexation of phospholipids and cholesterol by triterpenic saponins in bulk and in monolayers.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Cholesterol; Glycyrrhetinic Acid; Membranes, Artificial; Oleanolic Acid; Saponins | 2016 |
Oleanane type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao.
Topics: Astragalus propinquus; Hep G2 Cells; Humans; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Saponins | 2016 |
Triterpene saponins with α-glucosidase inhibition and cytotoxic activity from the leaves of Schefflera sessiliflora.
Topics: Antineoplastic Agents, Phytogenic; Araliaceae; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Saponins; Triterpenes | 2016 |
Anti-melanoma activity of Bupleurum chinense, Bupleurum kaoi and nanoparticle formulation of their major bioactive compound saikosaponin-d.
Topics: Apoptosis Regulatory Proteins; Bupleurum; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drugs, Chinese Herbal; Humans; MAP Kinase Signaling System; Melanoma; Membrane Potential, Mitochondrial; Nanoparticles; Oleanolic Acid; Particle Size; Plant Roots; Saponins; Solubility | 2016 |
HepG2 cells biospecific extraction and HPLC-ESI-MS analysis for screening potential antiatherosclerotic active components in Bupeuri radix.
Topics: Atherosclerosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Medicine, Chinese Traditional; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization | 2016 |
Development of an Enzyme-Linked Immunosorbent Assay and Immunoaffinity Column Chromatography for Saikosaponin d Using an Anti-Saikosaponin d Monoclonal Antibody.
Topics: Animals; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred BALB C; Oleanolic Acid; Saponins; Sensitivity and Specificity | 2016 |
Binding between Saikosaponin C and Human Serum Albumin by Fluorescence Spectroscopy and Molecular Docking.
Topics: Binding Sites; Circular Dichroism; Energy Transfer; Humans; Hydrogen Bonding; Models, Molecular; Molecular Docking Simulation; Oleanolic Acid; Protein Binding; Protein Conformation; Saponins; Serum Albumin; Spectrometry, Fluorescence | 2016 |
Oleanane-type triterpene saponins from Hydrocotyle nepalensis.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Centella; Humans; Molecular Structure; Oleanolic Acid; Saponins | 2016 |
Saikosaponin-a Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells.
Topics: Atherosclerosis; ATP Binding Cassette Transporter 1; CD36 Antigens; Cell Culture Techniques; Cholesterol; Cytokines; Humans; Lipoproteins; Lipoproteins, LDL; Macrophages; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; PPAR gamma; Receptors, Lipoprotein; Saponins | 2016 |
Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake.
Topics: Antineoplastic Agents, Phytogenic; Camellia; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Conformation; Oleanolic Acid; Plant Extracts; Saponins | 2016 |
Determination and validation of chikusetsusaponin IVa in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study.
Topics: Animals; Biological Availability; Oleanolic Acid; Rats; Saponins; Tandem Mass Spectrometry | 2016 |
Effect of α-Hederin on IL-2 and IL-17 mRNA and miRNA-133a Levels in Lungs of Ovalbumin-Sensitized Male Rats.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Interleukin-17; Interleukin-2; Lung; Male; MicroRNAs; Oleanolic Acid; Ovalbumin; Rats, Wistar; RNA, Messenger; Saponins | 2016 |
α-Hederin inhibits G protein-coupled receptor kinase 2-mediated phosphorylation of β2-adrenergic receptors.
Topics: Cyclic AMP-Dependent Protein Kinases; G-Protein-Coupled Receptor Kinase 2; Hedera; HEK293 Cells; Humans; Isoproterenol; Oleanolic Acid; Phosphorylation; Receptors, Adrenergic, beta-2; Recombinant Fusion Proteins; Saponins; Signal Transduction | 2016 |
Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice.
Topics: Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Glutathione; Hippocampus; Interleukins; Male; Malondialdehyde; Maze Learning; Memory; Memory Disorders; Mice; Neuroprotective Agents; Oleanolic Acid; Oxidative Stress; Polygala; Random Allocation; Saponins; Scopolamine; Superoxide Dismutase | 2016 |
Chikusetsusaponin IVa Butyl Ester (CS-IVa-Be), a Novel IL6R Antagonist, Inhibits IL6/STAT3 Signaling Pathway and Induces Cancer Cell Apoptosis.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Interleukin-6; MCF-7 Cells; Neoplasms; Oleanolic Acid; Receptors, Interleukin-6; Saponins; Signal Transduction; STAT3 Transcription Factor; TNF-Related Apoptosis-Inducing Ligand | 2016 |
Macranthoside B Induces Apoptosis and Autophagy Via Reactive Oxygen Species Accumulation in Human Ovarian Cancer A2780 Cells.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Humans; Oleanolic Acid; Ovarian Neoplasms; Reactive Oxygen Species; Saponins; TOR Serine-Threonine Kinases | 2016 |
Saikosaponin-D Reduces H
Topics: Animals; Antioxidants; Apoptosis; Bupleurum; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oleanolic Acid; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Saponins | 2016 |
Ultrasensitive Time-Resolved Fluoroimmunoassay for Saikosaponin a in Chaihu (Bupleuri Radix).
Topics: Apiaceae; Drugs, Chinese Herbal; Fluoroimmunoassay; Oleanolic Acid; Reproducibility of Results; Saponins | 2016 |
UFLC-MS/MS determination and pharmacokinetic studies of six Saikosaponins in rat plasma after oral administration of Bupleurum Dropping Pills.
Topics: Administration, Oral; Animals; Bupleurum; Limit of Detection; Oleanolic Acid; Plant Extracts; Rats; Reference Standards; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
Chemical constituents from rhizome of Anemone amurensis.
Topics: Anemone; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Extracts; Rhizome; Saponins | 2016 |
Two new 28-nor-oleanane-type triterpene saponins from roots of Camellia oleifera and their cytotoxic activity.
Topics: Antineoplastic Agents, Phytogenic; Camellia; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Saponins | 2016 |
[Evaluation for Merchandise Character and Quality of Bupleurum chinense Root from Different Habitats].
Topics: Bupleurum; Drugs, Chinese Herbal; Ecosystem; Flavonoids; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2015 |
[Effect of Esculentoside A on Expression of AQP2 and AQP4 Protein of Kidney in Water-Loaded Rats].
Topics: Animals; Aquaporin 2; Aquaporin 4; Diuresis; Kidney; Male; Oleanolic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Saponins | 2015 |
Eclalbasaponin II induces autophagic and apoptotic cell death in human ovarian cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Oleanolic Acid; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Saponins; TOR Serine-Threonine Kinases | 2016 |
In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydroxylation; Microsomes, Liver; Oleanolic Acid; Rats; Saponins | 2017 |
Two new isoxazolines from the husks of Xanthoceras sorbifolia Bunge.
Topics: Cell Proliferation; Cholinesterase Inhibitors; Crystallography, X-Ray; Drugs, Chinese Herbal; Humans; Isoxazoles; Molecular Docking Simulation; Molecular Structure; Oleanolic Acid; Sapindaceae; Saponins; Stereoisomerism; Triterpenes | 2016 |
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor.
Topics: Allosteric Regulation; Animals; Bupleurum; Cyclopentanes; Ethanol; GABA-B Receptor Antagonists; Male; Morpholines; Motivation; Motor Activity; Oleanolic Acid; Pyrimidines; Rats; Receptors, GABA-B; Reinforcement, Psychology; Saponins; Self Administration | 2016 |
Saikosaponin A, an active glycoside from Radix bupleuri, reverses P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cells and HepG2/ADM cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Resistance, Multiple; Hep G2 Cells; Humans; Oleanolic Acid; Saponins | 2017 |
Chikusetsusaponin IVa Methyl Ester Isolated from the Roots of Achyranthes japonica Suppresses LPS-Induced iNOS, TNF-α, IL-6, and IL-1β Expression by NF-κB and AP-1 Inactivation.
Topics: Achyranthes; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Dinoprostone; Esters; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Oleanolic Acid; Plant Roots; RAW 264.7 Cells; Saponins; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2016 |
Saikosaponin-d: A potential chemotherapeutics in castration resistant prostate cancer by suppressing cancer metastases and cancer stem cell phenotypes.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Feasibility Studies; Humans; Male; Neoplasm Invasiveness; Neoplastic Stem Cells; Oleanolic Acid; Prostatic Neoplasms, Castration-Resistant; Saponins | 2016 |
Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.
Topics: Cell Line, Tumor; Flowers; Gastrointestinal Neoplasms; Humans; Oleanolic Acid; Saponins; Triterpenes | 2016 |
Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Inhibitory Concentration 50; Lethal Dose 50; Liver Neoplasms; MCF-7 Cells; Mice; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Saponins; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Protection against 1-methyl-4-phenyl pyridinium-induced neurotoxicity in human neuroblastoma SH-SY5Y cells by Soyasaponin I by the activation of the phosphoinositide 3-kinase/AKT/GSK3β pathway.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Humans; Neuroprotective Agents; Oleanolic Acid; Parkinson Disease; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Saponins; Signal Transduction | 2016 |
The inhibitory effects of nor-oleanane triterpenoid saponins from Stauntonia brachyanthera towards UDP-glucuronosyltransferases.
Topics: Drugs, Chinese Herbal; Glucuronosyltransferase; Herb-Drug Interactions; Magnoliopsida; Molecular Structure; Oleanolic Acid; Saponins | 2016 |
Anti-Inflammation Effects and Potential Mechanism of Saikosaponins by Regulating Nicotinate and Nicotinamide Metabolism and Arachidonic Acid Metabolism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Biomarkers; Chromatography, High Pressure Liquid; Mass Spectrometry; Metabolism; Metabolomics; Mice; Niacin; Niacinamide; Oleanolic Acid; Saponins | 2016 |
Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway.
Topics: Animals; Apoptosis; Down-Regulation; Epilepsy; Hippocampus; Interleukin-1beta; Leucine; Male; Neurons; Neuroprotective Agents; Oleanolic Acid; Pentylenetetrazole; Phosphorylation; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Saponins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2016 |
Cytotoxic triterpenoid saponins from Clematis tangutica.
Topics: Antineoplastic Agents, Phytogenic; Clematis; Drug Screening Assays, Antitumor; Hep G2 Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Oleanolic Acid; Phytotherapy; Plant Roots; Saponins; Triterpenes | 2016 |
Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter 1; Cell Membrane; Cell Survival; Cholesterol; Cytokines; Endotoxemia; Female; Inflammation; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver X Receptors; Macrophages; Male; Membrane Microdomains; Mice; Mice, Inbred BALB C; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction; Toll-Like Receptor 4; Treatment Outcome | 2016 |
Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana.
Topics: Antineoplastic Agents, Phytogenic; Cytotoxins; Fibroblasts; Leishmania; Magnoliopsida; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Saponins; Triterpenes | 2016 |
Pharmacokinetic parameters of three active ingredients hederacoside C, hederacoside D, and ɑ-hederin in Hedera helix in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Hedera; Male; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry | 2016 |
Chemical Composition and Bioactivities of Two Common Chaenomeles Fruits in China: Chaenomeles speciosa and Chaenomeles sinensis.
Topics: alpha-Glucosidases; Antioxidants; Biphenyl Compounds; Catechin; China; Chromatography, High Pressure Liquid; Coumaric Acids; Flavonoids; Fruit; Gallic Acid; Glycoside Hydrolase Inhibitors; Oleanolic Acid; Phenols; Picrates; Plant Extracts; Proanthocyanidins; Propionates; Rosaceae; Rutin; Saponins; Species Specificity; Triterpenes; Ursolic Acid; Vanillic Acid | 2016 |
Effects of Oleanane-Type Triterpene Saponins from the Leaves of Eleutherococcus senticosus in an Axonal Outgrowth Assay.
Topics: Amyloid beta-Peptides; Animals; Eleutherococcus; Female; Japan; Mice; Molecular Structure; Neuronal Outgrowth; Oleanolic Acid; Peptide Fragments; Plant Extracts; Plant Leaves; Pregnancy; Saponins | 2016 |
Oleanane-type triterpenoid saponins from Silene armeria.
Topics: Glycosylation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Sapogenins; Saponins; Silene; Triterpenes | 2016 |
Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Bupleurum; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Line; Cell Proliferation; Drugs, Chinese Herbal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Mitochondria; Oleanolic Acid; Oligopeptides; Rats; Saponins; Triterpenes | 2016 |
Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Molecular Structure; Momordica; Oleanolic Acid; Saponins | 2016 |
Pharmacokinetic study of ardisiacrispin A in rat plasma after intravenous administration by UPLC-MS/MS.
Topics: Animals; Chromatography, Liquid; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Tandem Mass Spectrometry | 2017 |
α-Hederin Induces Apoptosis, Membrane Permeabilization and Morphologic Changes in Two Cancer Cell Lines Through a Cholesterol-Dependent Mechanism.
Topics: Apoptosis; Calcium; Cell Membrane Permeability; Cholesterol; Humans; Oleanolic Acid; Saponins; U937 Cells | 2016 |
Vinegar amount in the process affected the components of vinegar-baked Radix Bupleuri and its hepatoprotective effect.
Topics: Acetic Acid; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Liver; Male; Oleanolic Acid; Plant Roots; Protective Agents; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins | 2016 |
Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions.
Topics: Hydrolysis; Molecular Structure; Oleanolic Acid; Saponins | 2016 |
Microbial transformation of hederagenin by Cunninghamella echinulate, Mucor subtilissimus, and Pseudomonas oleovorans.
Topics: Biotransformation; Cunninghamella; Molecular Structure; Mucor; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pseudomonas oleovorans; Saponins | 2017 |
Metabolic switching of astringent and beneficial triterpenoid saponins in soybean is achieved by a loss-of-function mutation in cytochrome P450 72A69.
Topics: Base Sequence; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Genetic Variation; Glycine max; Mixed Function Oxygenases; Molecular Structure; Mutation; Oleanolic Acid; Phylogeny; Plant Proteins; Saponins; Triterpenes | 2017 |
Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase 2; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; G1 Phase Cell Cycle Checkpoints; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Oleanolic Acid; Ovarian Neoplasms; Saponins | 2016 |
Cuspidate A, new anti-fungal triterpenoid saponin from Lepidagathis cuspidata.
Topics: Acanthaceae; Antifungal Agents; Aspergillus fumigatus; Drug Evaluation, Preclinical; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Penicillium; Plant Diseases; Plant Roots; Saponins; Triterpenes | 2017 |
Oleanane triterpene saponins with cardioprotective activity from Clinopodium polycephalum.
Topics: Cardiotonic Agents; Drugs, Chinese Herbal; Hydrogen Peroxide; Lamiaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Triterpenes | 2017 |
Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK/Akt/GSK3β pathway.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Analgesics, Non-Narcotic; Animals; Apoptosis Inducing Factor; bcl-2-Associated X Protein; CRISPR-Cas Systems; Female; Gene Deletion; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Heme Oxygenase-1; Hep G2 Cells; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Superoxides | 2016 |
Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenylate Kinase; alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Disease Models, Animal; Drugs, Chinese Herbal; Female; Hedera; Huntingtin Protein; Male; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Oleanolic Acid; PC12 Cells; Rats; Saponins; TOR Serine-Threonine Kinases | 2017 |
Structural analysis of oleanane-type saponins from the roots of Wisteria frutescens.
Topics: Chromatography, Gas; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization; Wisteria | 2017 |
Screening for Triterpenoid Saponins in Plants Using Hyphenated Analytical Platforms.
Topics: Barbarea; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Saponins; Triterpenes | 2016 |
Polyacetylenic Oleanane-Type Triterpene Saponins from the Roots of Panax japonicus.
Topics: Angiotensins; Animals; Cell Proliferation; Drugs, Chinese Herbal; Male; Molecular Structure; Neuroprotective Agents; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Panax; PC12 Cells; Plant Roots; Polyynes; Rats; Rats, Wistar; Saponins | 2016 |
Suppressing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on chocolate self-administration and reinstatement of chocolate seeking in rats.
Topics: Animals; Beverages; Bupleurum; Chocolate; Feeding Behavior; Male; Motivation; Oleanolic Acid; Rats, Wistar; Reinforcement, Psychology; Saponins; Self Administration | 2017 |
β-Amyrin synthase (EsBAS) and β-amyrin 28-oxidase (CYP716A244) in oleanane-type triterpene saponin biosynthesis in Eleutherococcus senticosus.
Topics: Amino Acid Sequence; Cytochrome P-450 Enzyme System; DNA, Complementary; Eleutherococcus; Intramolecular Transferases; Molecular Structure; Oleanolic Acid; Oxidoreductases; Panax; Plants, Medicinal; Saponins; Squalene; Triterpenes | 2017 |
Esculentoside A suppresses lipopolysaccharide-induced pro-inflammatory molecule production partially by casein kinase 2.
Topics: Animals; Casein Kinase II; Cells, Cultured; Drugs, Chinese Herbal; Interleukin-6; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Oleanolic Acid; Saponins; Tumor Necrosis Factor-alpha | 2017 |
Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae).
Topics: Acacia; Antineoplastic Agents, Phytogenic; Cameroon; Drug Screening Assays, Antitumor; HeLa Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Saponins | 2017 |
Renin inhibition by soyasaponin I: a potent native anti-hypertensive compound.
Topics: Antihypertensive Agents; Catalytic Domain; Humans; Hypertension; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Oleanolic Acid; Protein Binding; Renin; Renin-Angiotensin System; Saponins; Thermodynamics | 2018 |
Stimulation of Osteogenic Differentiation by Saikosaponin-A in Bone Marrow Stromal Cells Via WNT/β-Catenin Pathway.
Topics: Animals; beta Catenin; Bone Marrow Cells; Cell Differentiation; Female; Mesenchymal Stem Cells; Mice, Inbred C57BL; Oleanolic Acid; Osteogenesis; Saponins; Transcription Factors; Wnt Signaling Pathway | 2017 |
Saikosaponin a Induces Apoptosis through Mitochondria-Dependent Pathway in Hepatic Stellate Cells.
Topics: Animals; Apoptosis; Bupleurum; Caspase 3; Cell Proliferation; Cells, Cultured; Hepatic Stellate Cells; Mitochondria; Oleanolic Acid; Rats; Saponins; Stimulation, Chemical | 2017 |
Syntheses and mucosal adjuvant activity of simplified oleanolic acid saponins possessing cinnamoyl ester.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Influenza Vaccines; Mice; Mice, Inbred BALB C; Nasal Mucosa; Oleanolic Acid; Saponins; Spectrum Analysis | 2017 |
New Sweet-Tasting Oleanane-Type Triterpenoid Saponins from "Tugancao" (Derris eriocarpa How).
Topics: Animals; China; Derris; Female; Humans; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Plant Stems; Saponins; Sweetening Agents; Taste; Wine | 2017 |
Artefact formation during acid hydrolysis of saponins from Medicago spp.
Topics: Artifacts; Gas Chromatography-Mass Spectrometry; Glycosides; Hydrolysis; Magnetic Resonance Spectroscopy; Medicago; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 2017 |
Synthesis and cytotoxicity of oleanolic acid trisaccharide saponins.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Oleanolic Acid; Saponins; Structure-Activity Relationship; Trisaccharides | 2017 |
Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Etoposide; Melanoma; Mice; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction | 2017 |
Anti-influenza triterpenoid saponins (saikosaponins) from the roots of Bupleurum marginatum var. stenophyllum.
Topics: Antiviral Agents; Bupleurum; Cell Line; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Oleanolic Acid; Plant Roots; Saponins; Structure-Activity Relationship | 2017 |
Oleanane-type Saponins from Glochidion hirsutum and Their Cytotoxic Activities.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Magnoliopsida; Molecular Structure; Oleanolic Acid; Plant Leaves; Saponins | 2017 |
Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro.
Topics: Animals; Apoptosis; Caspase 3; DNA Fragmentation; Dose-Response Relationship, Drug; Embryophyta; Female; In Situ Nick-End Labeling; Inhibitory Concentration 50; Lethal Dose 50; Oleanolic Acid; Oxidative Stress; Plant Bark; Plant Extracts; Plant Leaves; Reactive Oxygen Species; Saponins; Seeds; Setaria Nematode; Setariasis; Staining and Labeling; Triterpenes | 2017 |
Chikusetsu (CHI) triggers mitochondria-regulated apoptosis in human prostate cancer via reactive oxygen species (ROS) production.
Topics: Apoptosis; Apoptosis Inducing Factor; Caspases; Cell Line, Tumor; Cell Proliferation; Endodeoxyribonucleases; Humans; Male; Mitochondria; Oleanolic Acid; Prostatic Neoplasms; Reactive Oxygen Species; Saponins; Signal Transduction | 2017 |
Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri.
Topics: Acetic Acid; Animals; Animals, Newborn; Apoptosis; Bupleurum; Cardiotoxicity; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Hep G2 Cells; Hot Temperature; Humans; Male; Myocytes, Cardiac; Oleanolic Acid; Plant Preparations; Plant Roots; Rats, Sprague-Dawley; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2017 |
Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling.
Topics: Adenosine Triphosphate; Adipose Tissue; Animals; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Homeostasis; Inflammasomes; Lipid Metabolism; Lipopolysaccharides; Macrophages; Male; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Panniculitis; Saponins; Signal Transduction | 2017 |
Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bupleurum; Cholesterol; Cytochrome P-450 CYP2E1; Drugs, Chinese Herbal; Female; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Lipid Metabolism; Liver; Liver Diseases; Male; Mice; Nitric Oxide Synthase Type II; Oleanolic Acid; Oxidative Stress; Plant Roots; Proteomics; Saponins; Triglycerides | 2017 |
α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; beta-Galactoside alpha-2,3-Sialyltransferase; Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Drug Synergism; ErbB Receptors; Female; Humans; Immunohistochemistry; Immunoprecipitation; Kaplan-Meier Estimate; Mice; Mice, Inbred C57BL; Microarray Analysis; Neoplasm Invasiveness; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Oleanolic Acid; Ovarian Neoplasms; Ovary; Peritoneal Neoplasms; Peritoneum; Prognosis; Protein Kinase Inhibitors; Saponins; Sialyltransferases; Signal Transduction; Survival Rate | 2017 |
Triterpenoid saponins from the roots of Spergularia marginata.
Topics: Caryophyllaceae; Humans; Molecular Structure; Morocco; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Roots; Saponins; Triterpenes | 2017 |
Two new triterpenoid saponins from the leaves of Bupleurum lancifolium (Apiaceae).
Topics: Apiaceae; Bupleurum; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Leaves; Saponins; Spectrum Analysis; Triterpenes | 2017 |
Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells.
Topics: Animals; Cactaceae; Cell Line, Tumor; Glycosides; Melanins; Melanoma, Experimental; Molecular Structure; Oleanolic Acid; Plant Extracts; Saponins; Triterpenes | 2017 |
Oleanane-type glycosides from Pittosporum tenuifolium "variegatum" and P. tenuifolium "gold star".
Topics: Glycosides; Molecular Structure; Oleanolic Acid; Plant Extracts; Rosales; Saponins | 2017 |
Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Oleanolic Acid; Rhodamine 123; Saponins; Time Factors | 2017 |
New oleanane saponins from the roots of Dendrobangia boliviana identified by LC-SPE-NMR.
Topics: Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Structure; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2017 |
Chemical constituents and biological activities of Dianthus elegans var. elegans.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dianthus; Drug Screening Assays, Antitumor; Glycosides; HEK293 Cells; HeLa Cells; Hemolysis; Hemolytic Agents; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Components, Aerial; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2018 |
Effects of Saikosaponin D on apoptosis in human U87 glioblastoma cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Shape; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Saponins; Up-Regulation | 2017 |
Bioassay-guided isolation of saikosaponins with agonistic activity on 5-hydroxytryptamine 2C receptor from Bupleurum chinense and their potential use for the treatment of obesity.
Topics: Animals; Anti-Obesity Agents; Biological Assay; Bupleurum; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Serotonin 5-HT2 Receptor Agonists; Structure-Activity Relationship | 2017 |
Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Urea Nitrogen; Cecum; Cells, Cultured; Creatinine; Dose-Response Relationship, Drug; Inflammation Mediators; Kidney Tubules; Ligation; Lipopolysaccharides; Male; Oleanolic Acid; Phytolacca; Phytotherapy; Punctures; Rats, Sprague-Dawley; Saponins; Sepsis | 2017 |
Investigation of the Hepatoprotective Effect of Prunus mume Sieb. et Zucc Extract in a Mouse Model of Alcoholic Liver Injury Through High-Resolution Metabolomics.
Topics: Animals; Antioxidants; Chromatography, Liquid; Disease Models, Animal; Ethanol; Fatty Liver, Alcoholic; Humans; Liver; Male; Mass Spectrometry; Metabolomics; Mice; Mice, Inbred C57BL; Oleanolic Acid; Phosphatidylcholines; Prunus; Saponins | 2017 |
Three new oleanane-type triterpenoid saponins from the seeds of Celosia cristata L.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Celosia; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Saponins; Seeds | 2018 |
Esculentoside A inhibits LPS-induced acute kidney injury by activating PPAR-γ.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Cytokines; Disease Models, Animal; Interleukin-1beta; Interleukin-6; Kidney; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Oleanolic Acid; PPAR gamma; Saponins; Tumor Necrosis Factor-alpha | 2017 |
Screening Specific Biomarkers of Herbs Using a Metabolomics Approach: A Case Study of Panax ginseng.
Topics: Biomarkers; Chromatography, High Pressure Liquid; Ginsenosides; Metabolomics; Oleanolic Acid; Panax; Saponins | 2017 |
Isolation of Three Triterpene Saponins, Including Two New Oleanane Derivatives, from Soldanella alpina and Hydrophilic Interaction Liquid Chromatography-Evaporative Light Scattering Detection of these Three Saponins in Four Soldenella Species.
Topics: Chromatography, Liquid; Light; Molecular Structure; Oleanolic Acid; Primulaceae; Saponins; Scattering, Radiation; Species Specificity; Triterpenes | 2017 |
Soyasaponin Ag inhibits α‑MSH‑induced melanogenesis in B16F10 melanoma cells via the downregulation of TRP‑2.
Topics: alpha-MSH; Animals; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Intramolecular Oxidoreductases; Melanins; Melanoma; Mice; Neoplasm Proteins; Oleanolic Acid; Saponins | 2017 |
Esculentoside A inhibits LPS-induced BV2 microglia activation through activating PPAR-γ.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Oleanolic Acid; PPAR gamma; Saponins | 2017 |
Robot-Applied Resistance Augments the Effects of Body Weight-Supported Treadmill Training on Stepping and Synaptic Plasticity in a Rodent Model of Spinal Cord Injury.
Topics: Animals; Disease Models, Animal; Exercise Therapy; Female; Hindlimb; Motor Activity; Neuronal Plasticity; Oleanolic Acid; Rats, Sprague-Dawley; Recovery of Function; Robotics; Saponins; Spinal Cord; Spinal Cord Injuries; Synaptophysin | 2017 |
The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model.
Topics: Animals; Biological Transport; Dogs; Drugs, Chinese Herbal; Flavanones; Glucosides; Glycyrrhizic Acid; Humans; Madin Darby Canine Kidney Cells; Models, Biological; Monoterpenes; Oleanolic Acid; Permeability; Saponins; Verapamil | 2021 |
Cytotoxic oleanane triterpenoid saponins from Albizia julibrissin.
Topics: Albizzia; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oleanolic Acid; Plant Bark; Saponins; Structure-Activity Relationship | 2017 |
Soyasapogenol B and Genistein Attenuate Lipopolysaccharide-Induced Memory Impairment in Mice by the Modulation of NF-κB-Mediated BDNF Expression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Fermentation; Genistein; Glycine max; Humans; Lipopolysaccharides; Male; Memory Disorders; Mice; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Plant Extracts; Saponins | 2017 |
Esculentoside A exerts anti-inflammatory activity in microglial cells.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Dinoprostone; Humans; Lipopolysaccharides; Microglia; Neurodegenerative Diseases; Neurogenic Inflammation; NF-kappa B; Nitric Oxide; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Phytolaccaceae; Rats; Saponins; Signal Transduction | 2017 |
Albidosides H and I, two new triterpene saponins from the barks of Acacia albida Del. (Mimosaceae).
Topics: Acacia; Drug Screening Assays, Antitumor; HeLa Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Bark; Saponins; Triterpenes | 2018 |
[Expression of key enzyme genes and content of saikosaponin in saikosaponin biosynthesis under drought stress in Bupleurum chinense].
Topics: Bupleurum; Droughts; Gene Expression Regulation, Plant; Oleanolic Acid; Plant Proteins; Saponins; Water | 2016 |
Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis.
Topics: Animals; Antidepressive Agents; Arousal; Corticosterone; Depression; Doublecortin Protein; Hippocampus; Hypothalamo-Hypophyseal System; Male; Motivation; Neurogenesis; Oleanolic Acid; Phytotherapy; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Saponins; Stress, Psychological | 2017 |
[Triterpenoid saponins from Bupleurum marginatum var. stenophyllum].
Topics: Bupleurum; Drugs, Chinese Herbal; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Triterpenes | 2016 |
Oleanane-type triterpene saponins from Calendula stellata.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents, Phytogenic; Calendula; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fungi; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Molecular Conformation; Oleanolic Acid; Saponins; Structure-Activity Relationship; Triterpenes | 2017 |
[Pharmacokinetics and tissue distribution of α-hederin sodium salt in rats].
Topics: Administration, Oral; Animals; Liver; Oleanolic Acid; Rats; Saponins; Tandem Mass Spectrometry; Tissue Distribution | 2016 |
Antifungal activity of sterols and dipsacus saponins isolated from Dipsacus asper roots against phytopathogenic fungi.
Topics: Antifungal Agents; Cholesterol; Dipsacaceae; Oleanolic Acid; Phytosterols; Plant Roots; Saponins; Sitosterols; Sterols | 2017 |
Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies.
Topics: Binding Sites; Bupleurum; Cell Degranulation; Cell Line; HEK293 Cells; Humans; Hydrogen Bonding; Immunoglobulin E; Mast Cells; Molecular Docking Simulation; Oleanolic Acid; Protein Binding; Receptors, G-Protein-Coupled; Saponins | 2017 |
Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins.
Topics: Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Biological Transport; Cholestenones; Cholesterol; Digitonin; Dimyristoylphosphatidylcholine; Erythrocyte Membrane; Fluoresceins; Glycyrrhizic Acid; Hemolysis; Humans; Membrane Lipids; Oleanolic Acid; Ornithogalum; Phosphatidylcholines; Saponins; Unilamellar Liposomes | 2017 |
Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain-Derived Neurotrophic Factor; Depression; Female; Oleanolic Acid; Perimenopause; Rats; Rats, Wistar; Saponins; Stress, Psychological | 2018 |
SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 1; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; MicroRNAs; Oleanolic Acid; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats, Wistar; Saponins; Transcription Factor AP-1 | 2017 |
Isolation and Structural Characterization of Echinocystic Acid Triterpenoid Saponins from the Australian Medicinal and Food Plant Acacia ligulata.
Topics: Acacia; Antineoplastic Agents, Phytogenic; Australia; Drug Screening Assays, Antitumor; Fibroblasts; Gas Chromatography-Mass Spectrometry; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Triterpenes | 2017 |
Simultaneous Determination of Soyasaponins and Isoflavones in Soy (Glycine max L.) Products by HPTLC-densitometry-Multiple Detection.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Densitometry; Glycine max; Isoflavones; Limit of Detection; Linear Models; Oleanolic Acid; Reproducibility of Results; Saponins | 2017 |
Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Caspase 1; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Neutrophil Infiltration; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Pulmonary Edema; Saponins; Tumor Necrosis Factor-alpha | 2018 |
Mechanism of the effect of saikosaponin on atherosclerosis in vitro is based on the MAPK signaling pathway.
Topics: Apoptosis Regulatory Proteins; Atherosclerosis; Biomarkers; Cytokines; Endothelial Cells; Humans; Lipoproteins, LDL; MAP Kinase Signaling System; NF-kappa B; Oleanolic Acid; Saponins; Superoxide Dismutase; Umbilical Veins | 2017 |
Highly efficient synthesis of bioactive oleanane-type saponins.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; HeLa Cells; Humans; Oleanolic Acid; Saponins; Structure-Activity Relationship; Triterpenes | 2017 |
The effect of saikosaponin D on doxorubicin pharmacokinetics and its MDR reversal in MCF-7/adr cell xenografts.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Interactions; Drug Resistance, Neoplasm; Humans; MCF-7 Cells; Mice; Oleanolic Acid; Saponins; Xenograft Model Antitumor Assays | 2017 |
[Comparison of different administration routes of saikosaponin in plasma pharmacokinetics and brain pharmacokinetics].
Topics: Administration, Intranasal; Animals; Biological Availability; Brain Chemistry; Chromatography, High Pressure Liquid; Injections; Mice; Oleanolic Acid; Plasma; Saponins; Tandem Mass Spectrometry | 2017 |
Congmujingnosides B-G, triterpene saponins from the stem of Aralia chinensis and their protective effects against H
Topics: Animals; Aralia; Cardiotonic Agents; Cell Line; Drug Evaluation, Preclinical; Free Radical Scavengers; Hydrogen Peroxide; Magnetic Resonance Spectroscopy; Molecular Structure; Myocytes, Cardiac; Oleanolic Acid; Plant Stems; Rats; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2019 |
Simultaneous determination of saikosaponin a, paeonol, and imperatorin, components of DA-9805, in rat plasma by LC-MS/MS and application to a pharmacokinetic study.
Topics: Acetophenones; Animals; Chromatography, Liquid; Drug Stability; Drugs, Chinese Herbal; Furocoumarins; Linear Models; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Tandem Mass Spectrometry | 2017 |
Saikosaponin-d-mediated downregulation of neurogenesis results in cognitive dysfunction by inhibiting Akt/Foxg-1 pathway in mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Cognitive Dysfunction; Dose-Response Relationship, Drug; Doublecortin Protein; Forkhead Transcription Factors; Hippocampus; Male; Maze Learning; Mice, Inbred ICR; Nerve Tissue Proteins; Neurogenesis; Oleanolic Acid; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction | 2018 |
Design, synthesis and cytotoxic activity of N-Modified oleanolic saponins bearing A glucosamine.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Glucosamine; Humans; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2018 |
D Rhamnose β-hederin inhibits migration and invasion of human breast cancer cell line MDA-MB-231.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Female; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Oleanolic Acid; Saponins; Treatment Outcome | 2018 |
Esculentoside A specifically binds to ribosomal protein S3a and impairs LPS-induced signaling in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Humans; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Oleanolic Acid; Phytolaccaceae; Protein Binding; RAW 264.7 Cells; Ribosomal Proteins; RNA, Small Interfering; Saponins; Signal Transduction; Surface Plasmon Resonance; Tumor Necrosis Factor-alpha | 2018 |
Cytochrome P450 CYP716A254 catalyzes the formation of oleanolic acid from β-amyrin during oleanane-type triterpenoid saponins biosynthesis in Anemone flaccida.
Topics: Catalysis; Cytochrome P-450 Enzyme System; Oleanolic Acid; Ranunculaceae; Saponins | 2018 |
Transcriptomic Analysis of Kalopanax septemlobus and Characterization of KsBAS, CYP716A94 and CYP72A397 Genes Involved in Hederagenin Saponin Biosynthesis.
Topics: Biocatalysis; Biosynthetic Pathways; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Kalopanax; Mevalonic Acid; Oleanolic Acid; Phylogeny; Plant Proteins; Saccharomyces cerevisiae; Saponins; Transcriptome | 2018 |
[Tissue distribution of araloside A in rats].
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Kidney; Liver; Lung; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Spleen; Tandem Mass Spectrometry; Tissue Distribution | 2017 |
Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo.
Topics: Animals; Edema; Immunoglobulin E; Male; Mast Cells; Mice; Oleanolic Acid; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Receptors, G-Protein-Coupled; Saponins | 2018 |
Estrogen receptor‑β‑dependent effects of saikosaponin‑d on the suppression of oxidative stress‑induced rat hepatic stellate cell activation.
Topics: Animals; Cell Proliferation; Cells, Cultured; Estradiol; Estrogen Receptor beta; Extracellular Matrix; Hepatic Stellate Cells; Hydrogen Peroxide; MAP Kinase Signaling System; Oleanolic Acid; Oxidative Stress; Rats; Saponins | 2018 |
[Research on topographic factors of ecology suitability regionalization of Bupleuri Radix in Hebei province].
Topics: Altitude; Bupleurum; China; Drugs, Chinese Herbal; Ecology; Ecosystem; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2017 |
Oleanane-type triterpenoid saponins from Lysimachia fortunei Maxim.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Plant Components, Aerial; Plants, Medicinal; Primulaceae; Saponins; Structure-Activity Relationship | 2018 |
Interaction between Saikosaponin D, Paeoniflorin, and Human Serum Albumin.
Topics: Binding Sites; Bupleurum; Drugs, Chinese Herbal; Glucosides; Humans; Hydrogen Bonding; Kinetics; Molecular Docking Simulation; Monoterpenes; Oleanolic Acid; Paeonia; Plant Extracts; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Saponins; Serum Albumin, Human; Thermodynamics | 2018 |
Immunomodulatory, hemolytic and cytotoxic activity potentials of triterpenoid saponins from eight Cephalaria species.
Topics: Antineoplastic Agents, Phytogenic; Dipsacaceae; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; HEK293 Cells; HeLa Cells; Hemolysis; Hemolytic Agents; Humans; Immunologic Factors; Oleanolic Acid; Saponins; Triterpenes; Turkey | 2018 |
Preservative effect of Camellia sinensis (L.) Kuntze seed extract in soy sauce and its mutagenicity.
Topics: Antifungal Agents; Camellia sinensis; Candida albicans; Escherichia coli; Food Microbiology; Food Preservation; Food Preservatives; Microbial Sensitivity Tests; Mutagenicity Tests; Oleanolic Acid; Plant Extracts; Salmonella typhimurium; Saponins; Seeds; Soy Foods; Zygosaccharomyces | 2018 |
Stereocontrolled synthesis of oleanolic saponin ladyginoside A isolated from Ladyginia bucharica.
Topics: Carbohydrate Sequence; Glycosides; Oleanolic Acid; Plant Extracts; Saponins; Triterpenes | 2018 |
Structural determination of two new acacic acid-type saponins from the stem barks of Albizia zygia (DC.) J. F. Macbr.
Topics: Albizzia; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Bark; Saponins; Spectrometry, Mass, Electrospray Ionization | 2019 |
α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells.
Topics: Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Humans; Interleukin-6; Janus Kinase 2; Oleanolic Acid; Saponins; Signal Transduction; STAT3 Transcription Factor | 2018 |
Discrimination of different geographic varieties of Gymnema sylvestre, an anti-sweet plant used for the treatment of type 2 diabetes.
Topics: 4-Chloro-7-nitrobenzofurazan; Deoxyglucose; Diabetes Mellitus, Type 2; Gymnema sylvestre; Hypoglycemic Agents; India; Oleanolic Acid; Plant Extracts; Plant Leaves; Saponins; Vietnam | 2018 |
Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria.
Topics: Algeria; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dipsacaceae; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Triterpenes | 2018 |
[Simultaneous determination of five saponins in Bupleuri Radix by HPLC-DAD dual wavelength method].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Saponins | 2018 |
A tandem array of UDP-glycosyltransferases from the UGT73C subfamily glycosylate sapogenins, forming a spectrum of mono- and bisdesmosidic saponins.
Topics: Barbarea; Brassinosteroids; Escherichia coli; Genes, Plant; Glycosides; Glycosylation; Glycosyltransferases; Models, Molecular; Nicotiana; Oleanolic Acid; Sapogenins; Saponins; Steroids, Heterocyclic; Tandem Repeat Sequences; Transcriptome | 2018 |
Total Saikosaponins of Bupleurum yinchowense reduces depressive, anxiety-like behavior and increases synaptic proteins expression in chronic corticosterine-treated mice.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Bupleurum; Corticosterone; Depression; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Oleanolic Acid; Plant Extracts; Receptors, AMPA; Saponins; Signal Transduction | 2018 |
Saikosaponin‑d alleviates carbon‑tetrachloride induced acute hepatocellular injury by inhibiting oxidative stress and NLRP3 inflammasome activation in the HL‑7702 cell line.
Topics: Apoptosis; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytokines; Inflammasomes; Inflammation Mediators; Liver; Malondialdehyde; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Oxidative Stress; Saponins | 2018 |
Saikosaponin a Inhibits Cigarette Smoke-Induced Oxidant Stress and Inflammatory Responses by Activation of Nrf2.
Topics: Animals; Cigarette Smoking; Heme Oxygenase-1; Membrane Proteins; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Pneumonia; Saponins; Smoke | 2018 |
Increased synthesis of a new oleanane-type saponin in hairy roots of marigold (Calendula officinalis) after treatment with jasmonic acid.
Topics: Agrobacterium; Calendula; Chromatography, High Pressure Liquid; Cyclopentanes; Glucuronides; Glycosides; Oleanolic Acid; Oxylipins; Plant Roots; Saponins | 2019 |
The role of α2,3-linked sialylation on clear cell type epithelial ovarian cancer.
Topics: Adenocarcinoma, Clear Cell; Animals; beta-Galactoside alpha-2,3-Sialyltransferase; Cadherins; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cystadenocarcinoma, Serous; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasms, Glandular and Epithelial; Oleanolic Acid; Ovarian Neoplasms; Saponins; Sialyltransferases | 2018 |
Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ-AMPK-mTOR pathway in ADPKD cells.
Topics: AMP-Activated Protein Kinases; Autophagy; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Transformed; Cell Proliferation; Gene Expression Regulation, Enzymologic; Humans; Oleanolic Acid; Polycystic Kidney, Autosomal Dominant; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Macranthoidin B Modulates Key Metabolic Pathways to Enhance ROS Generation and Induce Cytotoxicity and Apoptosis in Colorectal Cancer.
Topics: Amino Acids; Animals; Apoptosis; Carbohydrate Metabolism; Caspase 3; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Discriminant Analysis; Gas Chromatography-Mass Spectrometry; Glutathione Peroxidase; HCT116 Cells; Humans; Least-Squares Analysis; Lipid Metabolism; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Nude; Oleanolic Acid; Reactive Oxygen Species; S-Adenosylhomocysteine; Saponins; Superoxide Dismutase; Transplantation, Heterologous | 2018 |
Saikosaponin A Inhibits LPS-Induced Endometritis in Mice Through Activating Nrf2 Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endometritis; Female; Heme Oxygenase-1; Lipopolysaccharides; Mice; NF-E2-Related Factor 2; NF-kappa B; NF-KappaB Inhibitor alpha; Oleanolic Acid; Phosphorylation; Protective Agents; Saponins; Signal Transduction | 2018 |
[Neuroprotective effects and mechanism of saikosaponin A on acute spinal cord injury in rats].
Topics: Animals; Neuroprotective Agents; NF-kappa B; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Spinal Cord; Spinal Cord Injuries; Tumor Necrosis Factor-alpha | 2017 |
[The molecular identification of Bupleurum medicinal species and the quality investigation of Bupleuri Radix].
Topics: Bupleurum; China; Chromatography, High Pressure Liquid; DNA, Ribosomal Spacer; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2017 |
Anti-Proliferation Effect of Theasaponin E₁ on the ALDH-Positive Ovarian Cancer Stem-Like Cells.
Topics: Aldehyde Dehydrogenase; Biomarkers; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Structure; Neoplastic Stem Cells; Oleanolic Acid; Ovarian Neoplasms; Saponins; Tea | 2018 |
Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of
Topics: Acacia; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Oleanolic Acid; Plant Leaves; Saponins | 2019 |
Identification of quantitative trait loci associated with soyasaponin I concentration in soybean seed.
Topics: Chromosome Mapping; Glycine max; Oleanolic Acid; Ontario; Phenotype; Quantitative Trait Loci; Saponins; Seeds | 2018 |
Esculentoside A suppresses breast cancer stem cell growth through stemness attenuation and apoptosis induction by blocking IL-6/STAT3 signaling pathway.
Topics: Aldehyde Dehydrogenase; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Interleukin-6; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Neoplastic Stem Cells; Oleanolic Acid; Saponins; Signal Transduction; STAT3 Transcription Factor | 2018 |
Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression.
Topics: Animals; Anti-Inflammatory Agents; Chondrocytes; Interleukin-1beta; Male; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Oleanolic Acid; Osteoarthritis; Rats, Sprague-Dawley; Saponins; Wnt Signaling Pathway | 2018 |
Intestinal absorption mechanisms of araloside A in situ single-pass intestinal perfusion and in vitro Caco-2 cell model.
Topics: Animals; Biological Availability; Biological Transport; Caco-2 Cells; Colon; Diffusion; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Kinetics; Male; Membrane Transport Modulators; Membrane Transport Proteins; Oleanolic Acid; Perfusion; Permeability; Rats, Sprague-Dawley; Saponins | 2018 |
Anti-Obesity Activities of Chikusetsusaponin IVa and
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Dolichos; Fatty Acid Synthases; Fatty Acid-Binding Proteins; Functional Food; Mice; Obesity; Oleanolic Acid; Phytotherapy; Plant Extracts; PPAR gamma; RNA, Messenger; Saponins; Seeds | 2018 |
Biocatalysis of Platycoside E and Platycodin D3 Using Fungal Extracellular β-Glucosidase Responsible for Rapid Platycodin D Production.
Topics: Animals; Anti-Inflammatory Agents; Aspergillus; beta-Glucosidase; Biocatalysis; Biotechnology; Biotransformation; Interleukin-6; Lipopolysaccharides; Mice; Oleanolic Acid; Platycodon; RAW 264.7 Cells; Saponins; Triterpenes | 2018 |
[Identification on Five Kinds of Easily Confused Bupleurum Medicinal Materials].
Topics: Bupleurum; Chromatography, Thin Layer; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Saponins | 2016 |
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Topics: A549 Cells; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Drug Synergism; Feedback, Physiological; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Oleanolic Acid; Phosphorylation; Saponins; Tumor Suppressor Protein p53 | 2018 |
Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling.
Topics: Apoptosis; beta Catenin; Cell Line; Cell Line, Tumor; Cell Proliferation; Female; HEK293 Cells; Humans; MCF-7 Cells; Medicine, Chinese Traditional; Oleanolic Acid; Plant Roots; Saponins; Triple Negative Breast Neoplasms; Wnt Proteins; Wnt Signaling Pathway | 2018 |
Saikosaponin B2 Suppresses Inflammatory Responses Through IKK/IκBα/NF-κB Signaling Inactivation in LPS-Induced RAW 264.7 Macrophages.
Topics: Animals; Anti-Inflammatory Agents; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Oleanolic Acid; RAW 264.7 Cells; Saponins; Signal Transduction | 2019 |
Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Injections, Intraperitoneal; Male; Molecular Conformation; Oleanolic Acid; Potassium Channel Blockers; Rats; Rats, Wistar; Saponins; Seizures; Shal Potassium Channels | 2018 |
New triterpenoid saponins from the leaves of Ilex chinensis.
Topics: Animals; Hep G2 Cells; Humans; Ilex; Macrophages; Mice; Molecular Structure; Nitric Oxide; Oleanolic Acid; Phytochemicals; Plant Leaves; Protective Agents; Saponins; Triterpenes | 2018 |
The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells.
Topics: Apoptosis; Autophagosomes; Autophagy; Carcinoma, Non-Small-Cell Lung; Cathepsins; Cell Line, Tumor; Cell Proliferation; Humans; Hydrogen-Ion Concentration; Lung Neoplasms; Lysosomes; Oleanolic Acid; Paclitaxel; Reactive Oxygen Species; Saponins; Tubulin Modulators | 2018 |
Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT.
Topics: Animals; Blotting, Western; Cell Survival; Cells, Cultured; Echocardiography; Endothelial Cells; Endothelium; Fibrosis; Hemodynamics; Male; Mice; Myocytes, Cardiac; Oleanolic Acid; Rats; Saponins; Signal Transduction | 2018 |
Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Cell Death; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; Female; Intracellular Fluid; Male; Mice; Mice, Inbred C57BL; Neocortex; Neurons; Oleanolic Acid; Saponins | 2019 |
Identification and Analysis of Compound Profiles of Sinisan Based on 'Individual Herb, Herb-Pair, Herbal Formula' before and after Processing Using UHPLC-Q-TOF/MS Coupled with Multiple Statistical Strategy.
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Multivariate Analysis; Oleanolic Acid; Principal Component Analysis; Saponins; Statistics as Topic; Tandem Mass Spectrometry | 2018 |
Esculentoside H inhibits colon cancer cell migration and growth through suppression of MMP-9 gene expression via NF-kB signaling pathway.
Topics: Animals; Cell Movement; Colonic Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neoplasm Proteins; NF-kappa B; Oleanolic Acid; Saponins | 2019 |
Endoplasmic reticulum stress triggered by Soyasapogenol B promotes apoptosis and autophagy in colorectal cancer.
Topics: Animals; Apoptosis; Autophagy; Cell Proliferation; Colorectal Neoplasms; Endoplasmic Reticulum Stress; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Saponins; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Soyasapogenol B exhibits anti-growth and anti-metastatic activities in clear cell renal cell carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Proliferation; Female; Humans; Kidney; Kidney Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Oleanolic Acid; Phosphotransferases (Alcohol Group Acceptor); Saponins; Tumor Cells, Cultured | 2019 |
Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway.
Topics: Animals; Autophagy; Cells, Cultured; Extracellular Matrix; Fibrosis; Male; Matrix Metalloproteinases; Oleanolic Acid; Organotin Compounds; Pancreas; Pancreatic Stellate Cells; Pancreatitis, Chronic; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Saponins; Signal Transduction; Smad Proteins; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1 | 2019 |
Biotransformation of Food-Derived Saponins, Platycosides, into Deglucosylated Saponins Including Deglucosylated Platycodin D and Their Anti-Inflammatory Activities.
Topics: Anti-Inflammatory Agents; Bacteria; Bacterial Proteins; beta-Glucosidase; Biocatalysis; Biotransformation; Glycosylation; Oleanolic Acid; Plant Extracts; Platycodon; Saponins; Triterpenes | 2019 |
Alpha-Hederin Nanopore for Single Nucleotide Discrimination.
Topics: Molecular Dynamics Simulation; Nanopores; Nanotechnology; Nucleotides; Oleanolic Acid; Polymers; Saponins | 2019 |
The cytochrome P450 CYP72A552 is key to production of hederagenin-based saponins that mediate plant defense against herbivores.
Topics: Animals; Barbarea; Cytochrome P-450 Enzyme System; Gene Duplication; Genome, Plant; Herbivory; Insecta; Moths; Oleanolic Acid; Oxidation-Reduction; Phylogeny; Quantitative Trait Loci; Saponins | 2019 |
Polysciosides J and K, two new oleanane-type triterpenoid saponins from the leaves of
Topics: Araliaceae; Glycosides; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Leaves; Saponins; Spectrum Analysis; Triterpenes; Vietnam | 2020 |
Oleanane-Type Saponins Biosynthesis in Panax notoginseng via Transformation of β-Amyrin Synthase Gene from Panax japonicus.
Topics: Gene Expression; Gene Transfer Techniques; Intramolecular Transferases; Oleanolic Acid; Panax; Panax notoginseng; Plants, Genetically Modified; Saponins; Triterpenes | 2019 |
Oleanolic acid 3-glucoside, a synthetic oleanane-type saponin, alleviates methylmercury toxicity in vitro and in vivo.
Topics: Animals; Caco-2 Cells; Dose-Response Relationship, Drug; Gastrointestinal Tract; Glucosides; Humans; Male; Methylmercury Compounds; Mice; Mice, Inbred BALB C; Oleanolic Acid; Random Allocation; Saponins | 2019 |
Inclusion complex of saikosaponin-d with hydroxypropyl-β-cyclodextrin: Improved physicochemical properties and anti-skin cancer activity.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents, Phytogenic; Bupleurum; Carcinoma, Squamous Cell; Cell Line, Tumor; Crystallography, X-Ray; Drug Compounding; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Oleanolic Acid; Saponins; Skin Neoplasms; Solubility; Spectroscopy, Fourier Transform Infrared; Water | 2019 |
Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary pathway for triterpene saponins biosynthesis and differential responsiveness to phytohormones.
Topics: Anemone; Biosynthetic Pathways; Cytochrome P-450 Enzyme System; Gene Expression Profiling; Gene Expression Regulation, Plant; Glycosyltransferases; Oleanolic Acid; Plant Growth Regulators; Plant Proteins; Plants, Medicinal; Rhizome; Saponins; Triterpenes | 2019 |
Revelation of the metabolic pathway of hederacoside C using an innovative data analysis strategy for dynamic multiclass biotransformation experiments.
Topics: Biotransformation; Chromatography, Liquid; Data Analysis; Feces; Gastrointestinal Microbiome; Glycosides; Herbal Medicine; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Models, Chemical; Oleanolic Acid; Saponins | 2019 |
The clickable activity-based probe of anti-apoptotic calenduloside E.
Topics: Apoptosis; Click Chemistry; Dose-Response Relationship, Drug; Flow Cytometry; HSP90 Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Models, Molecular; Molecular Docking Simulation; Oleanolic Acid; Saponins | 2019 |
A rapid and sensitive UHPLC-MS/MS method for the determination of celosin A in rat plasma with application to pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Female; Limit of Detection; Linear Models; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Tandem Mass Spectrometry | 2019 |
α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; HCT116 Cells; Humans; Male; Mice; Neoplasm Transplantation; Oleanolic Acid; Reactive Oxygen Species; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Antiviral effect of saikosaponin B2 in combination with daclatasvir on NS5A resistance-associated substitutions of hepatitis C virus.
Topics: Antiviral Agents; Carbamates; Cells, Cultured; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Imidazoles; Oleanolic Acid; Pyrrolidines; Saponins; Valine; Viral Nonstructural Proteins; Virus Replication | 2019 |
The antifungal activity and mechanisms of action of quantified extracts from berries, leaves and roots of Phytolacca tetramera.
Topics: Antifungal Agents; Argentina; Candida albicans; Candida glabrata; Ergosterol; Fruit; Humans; Methylene Chloride; Oleanolic Acid; Phytolacca; Plant Extracts; Plant Leaves; Plant Roots; Plants, Medicinal; Saponins; Tandem Mass Spectrometry | 2019 |
Anti-inflammatory Potential of Saponins from Aster tataricus via NF-κB/MAPK Activation.
Topics: Animals; Anti-Inflammatory Agents; Aster Plant; Lipopolysaccharides; MAP Kinase Signaling System; Mice; NF-kappa B; Oleanolic Acid; RAW 264.7 Cells; Saponins | 2019 |
New Oleanane-type glycosides and secoiridoid glucoside from
Topics: Glucosides; Glycosides; Iridoid Glucosides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oleanolic Acid; Plant Extracts; Saponins; Triterpenes | 2020 |
Untargeted Metabolomics Study of the In Vitro Anti-Hepatoma Effect of Saikosaponin d in Combination with NRP-1 Knockdown.
Topics: Carcinoma, Hepatocellular; Cell Survival; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Metabolomics; Molecular Docking Simulation; Molecular Targeted Therapy; Neuropilin-1; Oleanolic Acid; Saponins | 2019 |
Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Hep G2 Cells; Humans; Interleukin-1beta; Lipopolysaccharides; Liver; Liver X Receptors; Malondialdehyde; Mice, Inbred C57BL; Oleanolic Acid; Peroxidase; Saponins; Tumor Necrosis Factor-alpha | 2019 |
Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Cardiomyopathies; Fibrosis; Heart; Isoproterenol; Mice, Inbred BALB C; Myocardium; Myocytes, Cardiac; Oleanolic Acid; Phosphorylation; Saponins; Serine; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Saikosaponin A protects against dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Dextran Sulfate; Interleukin-1beta; Liver X Receptors; Male; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Saponins; Tumor Necrosis Factor-alpha | 2019 |
Determination of major components from Radix Achyranthes bidentate using ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry and an evaluation of their anti-osteoporosis effect in vitro.
Topics: 3T3 Cells; Animals; Cell Differentiation; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Mice; Oleanolic Acid; Osteoblasts; Osteoporosis; Plant Extracts; Saponins; Tandem Mass Spectrometry | 2019 |
Integration of targeted metabolite profiling and sequential optimization method for discovery of chemical marker combination to identify the closely-related plant species.
Topics: Biomarkers; Chromatography, Liquid; Flowers; Least-Squares Analysis; Lonicera; Metabolomics; Oleanolic Acid; Plants, Medicinal; Saponins; Species Specificity; Tandem Mass Spectrometry | 2019 |
In vitro studies on the metabolism of saikogenins and the detection of their metabolites in authentic biosamples.
Topics: Animals; Chromatography, High Pressure Liquid; Hydroxylation; Male; Microsomes, Liver; Oleanolic Acid; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry | 2019 |
Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus.
Topics: Animals; Bupleurum; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Fear; Female; Fulvestrant; Gene Expression Regulation; Hippocampus; Medicine, Chinese Traditional; Memory Disorders; Oleanolic Acid; Ovariectomy; Rats; Saponins; Temporal Lobe | 2019 |
A new oleanane type pentacyclic triterpenoid saponin from the husks of
Topics: Amyloid beta-Peptides; Animals; Cell Survival; Magnetic Resonance Spectroscopy; Molecular Structure; Neuroprotective Agents; Nuts; Oleanolic Acid; PC12 Cells; Peptide Fragments; Rats; Sapindaceae; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2020 |
Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line, Tumor; Coculture Techniques; Depression; Dose-Response Relationship, Drug; Humans; Lysophospholipids; Mice; Mice, Inbred ICR; Neurons; Oleanolic Acid; Random Allocation; Receptors, Lysophosphatidic Acid; Saponins | 2019 |
Effects of drought-re-watering-drought on the photosynthesis physiology and secondary metabolite production of Bupleurum chinense DC.
Topics: Bupleurum; Droughts; Oleanolic Acid; Photosynthesis; Plant Roots; Plants, Medicinal; Saponins; Secondary Metabolism; Soil; Stress, Physiological; Water | 2019 |
Modification of GSK3β/β-catenin signaling on saikosaponins-d-induced inhibition of neural progenitor cell proliferation and adult neurogenesis.
Topics: Animals; Avoidance Learning; beta Catenin; Cell Cycle; Cell Proliferation; Cell Survival; Dendrites; Glycogen Synthase Kinase 3 beta; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Oleanolic Acid; Saponins; Signal Transduction | 2019 |
Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cisplatin; Colchicine; Drug Resistance, Multiple; HEK293 Cells; Humans; Medicine, Chinese Traditional; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oleanolic Acid; Rhodamines; RNA, Messenger; Saponins; Up-Regulation | 2019 |
Pharmacokinetics and oral bioavailability studies of three saikogenins in rats using a validated UFLC-MS/MS method.
Topics: Animals; Biological Availability; Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Humans; Male; Oleanolic Acid; Plant Roots; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry | 2019 |
Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration.
Topics: Adolescent; Adult; Animals; Breast Neoplasms; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Mice; Microfilament Proteins; Middle Aged; Oleanolic Acid; Phosphoproteins; Saponins; STAT3 Transcription Factor; Young Adult | 2019 |
New 23, 27-dihydroxy-oleanane-type triterpenoid saponins from
Topics: A549 Cells; Anemone; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Pancreatic Neoplasms; Plant Extracts; Rhizome; Saponins; Triterpenes | 2021 |
α-Hederin Induces Apoptosis of Esophageal Squamous Cell Carcinoma via an Oxidative and Mitochondrial-Dependent Pathway.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Flow Cytometry; Humans; In Situ Nick-End Labeling; In Vitro Techniques; Male; Membrane Potential, Mitochondrial; Mice, Nude; Mitochondria; Neoplasm Transplantation; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Xenograft Model Antitumor Assays | 2019 |
Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin b
Topics: Animals; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Rats, Wistar; Saponins | 2019 |
[Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model].
Topics: Animals; Chemical and Drug Induced Liver Injury; Fatty Liver, Alcoholic; Oleanolic Acid; Saponins; Zebrafish | 2019 |
Hederacolchiside C inhibits Enterovirus 71 propagation through activating innate immunity.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Enterovirus A, Human; Hand, Foot and Mouth Disease; Host-Pathogen Interactions; Humans; Immunity, Innate; Mice; Oleanolic Acid; Pulsatilla; Saponins; Virus Replication | 2019 |
LC-MS analysis of saponins of Achyranthes root in the Japanese market.
Topics: Achyranthes; Chromatography, High Pressure Liquid; Chromatography, Liquid; Japan; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Tandem Mass Spectrometry | 2020 |
Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Ginsenosides; Hemolysis; Melanocytes; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Oleanolic Acid; Panax; Plant Extracts; Saponins; Skin Neoplasms | 2019 |
Alpha-Hederin, the Active Saponin of
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Mitochondria; Nigella sativa; Oleanolic Acid; Saponins | 2019 |
Five 11α, 12α-epoxy pentacyclic triterpenoid saponins with antithrombus activities from Glechoma longituba.
Topics: Animals; Blood Platelets; China; Female; Lamiaceae; Male; Mice; Molecular Structure; Oleanolic Acid; Partial Thromboplastin Time; Phytochemicals; Platelet Aggregation; Prothrombin Time; Rabbits; Saponins; Thrombin Time | 2019 |
[Calenduloside E inhibits lipopolysaccharide-induced inflammatory response by inhibiting activation of ROS-mediated JAK1-stat3 signaling pathway in RAW264.7 cells].
Topics: Animals; Lipopolysaccharides; Mice; NF-kappa B; Oleanolic Acid; RAW 264.7 Cells; Reactive Oxygen Species; Saponins; Signal Transduction | 2019 |
Saikosaponin C exerts anti-HBV effects by attenuating HNF1α and HNF4α expression to suppress HBV pgRNA synthesis.
Topics: Antiviral Agents; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 4; Humans; Oleanolic Acid; RNA; RNA Interference; RNA, Small Interfering; RNA, Viral; Saponins | 2019 |
[Esculentoside reduces expression of Th17 cell-related cytokines in the imiquimod-induced psoriasis-like dermatitis mouse model].
Topics: Animals; Cytokines; Dermatitis; Female; Imiquimod; Mice; Mice, Inbred BALB C; Oleanolic Acid; Psoriasis; Random Allocation; Saponins; Skin; Th17 Cells | 2019 |
Combining α-Hederin with cisplatin increases the apoptosis of gastric cancer in vivo and in vitro via mitochondrial related apoptosis pathway.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Oleanolic Acid; Reactive Oxygen Species; Saponins; Signal Transduction; Stomach Neoplasms | 2019 |
Soyasapogenol B Attenuates Laryngeal Carcinoma Progression through Inducing Apoptotic and Autophagic Cell Death.
Topics: Antineoplastic Agents; Apoptosis; Autophagic Cell Death; Carcinoma; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Laryngeal Neoplasms; Oleanolic Acid; Saponins | 2020 |
[Effects of saikosaponin b_2 on inflammation and energy metabolism in mice with acute liver injury induced by LPS/GalN].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Energy Metabolism; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Mice; NF-kappa B; Oleanolic Acid; Random Allocation; Saponins; Sirtuins | 2019 |
Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Cytokines; Diarrhea; Disease Models, Animal; Fluorouracil; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred BALB C; Mucositis; Oleanolic Acid; Saponins | 2019 |
Saikosaponin A ameliorates nasal inflammation by suppressing IL-6/ROR-γt/STAT3/IL-17/NF-κB pathway in OVA-induced allergic rhinitis.
Topics: Animals; Cytokines; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Inflammation; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Nasal Mucosa; NF-kappa B; Nuclear Receptor Subfamily 1, Group F, Member 3; Oleanolic Acid; Ovalbumin; Rhinitis, Allergic; Saponins; Signal Transduction; STAT3 Transcription Factor; Th17 Cells; Th2 Cells | 2020 |
Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of Saikosaponin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dopamine; Male; Oleanolic Acid; Proteome; Rats; Rats, Sprague-Dawley; Saponins; Stress, Psychological | 2020 |
α-Hederin induces the apoptosis of gastric cancer cells accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Stomach Neoplasms | 2020 |
Identification and characterization of saikosaponins as antagonists of transient receptor potential A1 channel.
Topics: Animals; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Neuralgia; Oleanolic Acid; Pain Measurement; Saponins; TRPA1 Cation Channel | 2020 |
Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway.
Topics: Animals; Fibroblasts; Fibrosis; Hedgehog Proteins; HEK293 Cells; Humans; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NIH 3T3 Cells; Oleanolic Acid; Rats; Saponins; Signal Transduction; Smoothened Receptor; Zinc Finger Protein Gli2 | 2020 |
Saikosaponin d downregulates microRNA-155 and upregulates FGF2 to improve depression-like behaviors in rats induced by unpredictable chronic mild stress by negatively regulating NF-κB.
Topics: Animals; Behavior, Animal; Depression; Fibroblast Growth Factor 2; Hindlimb Suspension; Hippocampus; Male; MicroRNAs; Neurons; NF-kappa B; Oleanolic Acid; Rats, Sprague-Dawley; Saponins; Signal Transduction; Stress, Psychological | 2020 |
Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation.
Topics: Animals; Antidepressive Agents; Cell Survival; Cells, Cultured; Depression; Encephalitis; HMGB1 Protein; Lipopolysaccharides; Male; Mice, Inbred ICR; Microglia; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction; Toll-Like Receptor 4 | 2020 |
Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway.
Topics: Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Intramolecular Transferases; Metabolic Networks and Pathways; Oleanolic Acid; Plant Proteins; Saponins; Squalene; Terminalia; Transcriptome | 2020 |
Two new oleanane triterpenoid saponins from
Topics: Influenza A Virus, H1N1 Subtype; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 2021 |
Potential Cytotoxicity, Pharmacokinetics, and Excretion Properties of Sapindoside B from the Seeds of Nigella sativa var. hispidula.
Topics: Animals; China; Chromatography, Liquid; Humans; Nigella sativa; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Seeds; Tandem Mass Spectrometry | 2020 |
Conversion of Glycosylated Platycoside E to Deapiose-Xylosylated Platycodin D by Cytolase PCL5.
Topics: Glycosylation; Oleanolic Acid; Plant Proteins; Platycodon; Saponins; Triterpenes | 2020 |
Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Humans; Inflammation Mediators; Male; Mice; Mice, Inbred BALB C; Mucins; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction | 2020 |
Novel method for improving ardicrenin content in hairy roots of Ardisia crenata Sims plants.
Topics: Agrobacterium; Ardisia; Chromatography, High Pressure Liquid; Oleanolic Acid; Plant Roots; Saponins | 2020 |
NAA and 6-BA promote accumulation of oleanolic acid by JA regulation in Achyranthes bidentata Bl.
Topics: Achyranthes; Benzyl Compounds; Biosynthetic Pathways; Cyclopentanes; Gene Expression Regulation, Plant; Genes, Plant; Medicine, Chinese Traditional; Naphthaleneacetic Acids; Oleanolic Acid; Oxylipins; Phylogeny; Plant Growth Regulators; Plants, Medicinal; Purines; RNA-Seq; Saponins | 2020 |
Chikusetsu saponin IVa alleviated sevoflurane-induced neuroinflammation and cognitive impairment by blocking NLRP3/caspase-1 pathway.
Topics: Anesthetics, Inhalation; Animals; Caspase 1; Caspase Inhibitors; Cognitive Dysfunction; Hippocampus; Inflammation Mediators; Male; Maze Learning; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Sevoflurane | 2020 |
Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Neoplasm Invasiveness; Oleanolic Acid; RNA-Binding Proteins; Saponins; Signal Transduction; Transcriptional Activation; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2020 |
Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponins.
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glucosamine; Humans; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Combination of saikosaponin c and telbivudine synergistically enhances the anti-HBV activity.
Topics: Antiviral Agents; DNA, Viral; Guanine; Hep G2 Cells; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Oleanolic Acid; Saponins; Telbivudine | 2020 |
An
Topics: COVID-19; Glycoproteins; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Oleanolic Acid; Saponins; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2021 |
Purposing Saikosaponins for the treatment of COVID-19.
Topics: Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome; Drug Repositioning; Humans; Immunologic Factors; Lymphocyte Activation; Molecular Docking Simulation; Oleanolic Acid; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Receptors, Virus; Saponins; SARS-CoV-2 | 2020 |
A New Oleanane Type Saponin from the Aerial Parts of
Topics: Antioxidants; Benzothiazoles; Biphenyl Compounds; Chromatography, High Pressure Liquid; Diabetes Mellitus; Flavonoids; Glycoside Hydrolase Inhibitors; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Nigella sativa; Oleanolic Acid; Picrates; Plant Components, Aerial; Plant Extracts; Protein Tyrosine Phosphatases; Saponins; Sulfonic Acids; Triterpenes | 2020 |
Hyaluronidase inhibitory saponins and a trypanocidal isoflavonoid from the aerial parts of Oxytropis lanata.
Topics: Antiprotozoal Agents; Hyaluronoglucosaminidase; Isoflavones; Molecular Structure; Mongolia; Oleanolic Acid; Oxytropis; Phytochemicals; Plant Components, Aerial; Plants, Medicinal; Saponins; Trypanosoma congolense | 2020 |
A new triterpenoid saponin with nine sugar units from
Topics: Anemone; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Molecular Structure; Oleanolic Acid; Saponins; Sugars; Triterpenes | 2021 |
Green Tea Seed Isolated Theasaponin E1 Ameliorates AD Promoting Neurotoxic Pathogenesis by Attenuating Aβ Peptide Levels in SweAPP N2a Cells.
Topics: Acetylcholinesterase; ADAM10 Protein; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Camellia sinensis; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation; Insulysin; Membrane Glycoproteins; Membrane Proteins; Mice; Neprilysin; Neurons; Neuroprotective Agents; Oleanolic Acid; Plant Extracts; Presenilins; Saponins; Seeds; Tea | 2020 |
Oleanane-type triterpene saponins from
Topics: Antineoplastic Agents, Phytogenic; Aralia; Humans; Molecular Structure; Oleanolic Acid; Plant Leaves; Saponins; Triterpenes | 2022 |
Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats.
Topics: Animals; Behavior, Addictive; Bupleurum; Chocolate; Ethanol; Female; Oleanolic Acid; Rats; Rats, Wistar; Saponins; Self Administration | 2020 |
Saikosaponin D inhibits autophagosome‑lysosome fusion and induces autophagy‑independent apoptosis in MDA‑MB‑231 breast cancer cells.
Topics: Apoptosis; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Lysosomes; Microtubule-Associated Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Saponins | 2020 |
Identification of phytolaccosides in biological samples from pokeweed intoxication patients using liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Humans; Limit of Detection; Linear Models; Oleanolic Acid; Phytolacca americana; Plant Extracts; Plant Poisoning; Reproducibility of Results; Saponins; Tandem Mass Spectrometry | 2020 |
Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Movement; Cell Proliferation; Cells, Cultured; Fibrosis; Inflammasomes; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Pancreatic Stellate Cells; Rats; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines.
Topics: Antineoplastic Agents, Phytogenic; Caco-2 Cells; Cameroon; Cell Line, Tumor; Drug Screening Assays, Antitumor; Fabaceae; Flowers; Humans; Molecular Structure; Oleanolic Acid; Phytochemicals; Plant Components, Aerial; Saponins; Triterpenes | 2020 |
Drought stress induces biosynthesis of flavonoids in leaves and saikosaponins in roots of Bupleurum chinense DC.
Topics: Bupleurum; Droughts; Flavonoids; Oleanolic Acid; Plant Leaves; Plant Roots; Saponins | 2020 |
In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Molecular Docking Simulation; Oleanolic Acid; Quillaja; Saponins; Stomach Neoplasms | 2020 |
Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-κB pathway.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line; Humans; Imiquimod; Immunosuppression Therapy; Inflammation; Keratinocytes; Mice; NF-kappa B; Oleanolic Acid; Reactive Oxygen Species; Saponins; Signal Transduction | 2020 |
Full-length transcriptome sequencing and modular organization analysis of oleanolic acid- and dammarane-type saponins related gene expression patterns in Panax japonicus.
Topics: Chromatography, High Pressure Liquid; Dammaranes; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Oleanolic Acid; Panax; Plant Roots; Rhizome; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2020 |
Effects of total saponins from Panacis majoris Rhizoma and its degradation products on myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Blood Viscosity; Chromatography, High Pressure Liquid; Ginsenosides; Hemodynamics; Magnetic Resonance Spectroscopy; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oleanolic Acid; Panax; Platelet Aggregation; Rats; Rats, Wistar; Rhizome; Saponins | 2020 |
[Determination of Absolute Purities of Hygroscopic Substances by Quantitative NMR Analysis for the Standardization of Quantitative Reagents in the Japanese Pharmacopoeia (Part 1)].
Topics: Drug Contamination; Ginsenosides; Humidity; Hygroscopic Agents; Indicators and Reagents; Japan; Magnetic Resonance Spectroscopy; Oleanolic Acid; Pharmacopoeias as Topic; Psychotherapy, Brief; Saponins; Temperature; Water | 2020 |
Standardized Saponin Extract from Baiye No.1 Tea (
Topics: Apoptosis; Camellia sinensis; Cell Line, Tumor; Cell Survival; Cyclin A2; Cyclin-Dependent Kinase Inhibitor p27; Female; Flowers; Gene Expression Regulation; Humans; Oleanolic Acid; Ovarian Neoplasms; Plant Extracts; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; S Phase Cell Cycle Checkpoints; Saponins; Signal Transduction; Tumor Suppressor Protein p53 | 2020 |
Reparative and toxicity-reducing effects of liposome-encapsulated saikosaponin in mice with liver fibrosis.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Compounding; Drug Liberation; Hepatic Stellate Cells; Humans; Inhibitory Concentration 50; Liposomes; Liver; Liver Cirrhosis, Experimental; Male; Mice, Inbred C57BL; Oleanolic Acid; Protective Agents; Saponins; Thioacetamide | 2020 |
Saikosaponin d contributed to cancer chemotherapy induced neutropenia therapy by promoting neutrophil differentiation via activation CBL-dependent ERK pathway.
Topics: Animals; Antineoplastic Agents; Blood Bactericidal Activity; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Immunologic Factors; Infection Control; Macrophage Activation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neutropenia; Neutrophils; Oleanolic Acid; Oncogene Protein v-cbl; Saponins | 2020 |
Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in
Topics: Animals; Anti-Inflammatory Agents; Glycosylation; Immunologic Factors; Mice; Nitric Oxide; Oleanolic Acid; Ranunculales; RAW 264.7 Cells; Saponins; Structure-Activity Relationship | 2020 |
Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Oleanolic Acid; Saponins; STAT3 Transcription Factor | 2020 |
Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway.
Topics: Animals; Dinoprostone; Humans; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Macrophages; Mice; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide; Oleanolic Acid; RAW 264.7 Cells; Saponins; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |
Semipapposides A-M, triterpenoid bidesmosides saponins from the roots of Scabiosa semipapposa.
Topics: Dipsacaceae; Molecular Structure; Oleanolic Acid; Plant Roots; Saponins; Triterpenes | 2020 |
Topological analysis of single-stranded DNA with an alpha-hederin nanopore.
Topics: Biosensing Techniques; DNA, Single-Stranded; Nanopores; Oleanolic Acid; Saponins; Sequence Analysis, DNA | 2021 |
Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis.
Topics: Animals; Glomerulonephritis; Lactic Acid; Mice; Mice, Inbred C57BL; Oleanolic Acid; Pyruvaldehyde; Saponins | 2020 |
MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell.
Topics: Animals; Anti-Inflammatory Agents; Glycogen Synthase Kinase 3 beta; Lipopolysaccharides; Mice; MicroRNAs; NF-kappa B; Oleanolic Acid; RAW 264.7 Cells; Saponins; Signal Transduction | 2020 |
Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Glycyrrhizic Acid; Humans; Interleukin-6; Liver; Macrophages; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Oleanolic Acid; Pentacyclic Triterpenes; Phosphorylation; Sapogenins; Saponins; Tumor Necrosis Factor-alpha | 2021 |
Saikosaponin A-Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1/Nrf2-ARE Antioxidant Signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidant Response Elements; Antioxidants; Gastrointestinal Microbiome; Kelch-Like ECH-Associated Protein 1; Male; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Pancreatitis; Rats; Rats, Sprague-Dawley; Saponins; Severity of Illness Index | 2020 |
Growth and Oleanolic Acid Accumulation of Polyscias fruticosa Cell Suspension Cultures.
Topics: Araliaceae; Cell Culture Techniques; Oleanolic Acid; Saponins; Triterpenes | 2021 |
Kalopanaxsaponin A induces reactive oxygen species mediated mitochondrial dysfunction and cell membrane destruction in Candida albicans.
Topics: Antifungal Agents; Candida albicans; Candidiasis; Cell Membrane; Drug Resistance, Fungal; Ergosterol; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; Reactive Oxygen Species; Saponins | 2020 |
Cloning, Yeast Expression, and Characterization of a β-Amyrin C-28 Oxidase (CYP716A249) Involved in Triterpenoid Biosynthesis in Polygala tenuifolia.
Topics: Arabidopsis Proteins; Cloning, Molecular; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Plant; Oleanolic Acid; Phylogeny; Polygala; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Saponins; Triterpenes | 2020 |
Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells.
Topics: Bupleurum; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Molecular Conformation; Oleanolic Acid; RNA, Messenger; Saponins | 2020 |
Saikosaponin a attenuates lead-induced kidney injury through activating Nrf2 signaling pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carps; Fish Diseases; Fish Proteins; Lead; Lead Poisoning; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidative Stress; Random Allocation; Saponins; Signal Transduction | 2021 |
Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7.
Topics: Analgesics; Angelica; Animals; Bupleurum; CHO Cells; Cricetulus; Disease Models, Animal; Drugs, Chinese Herbal; Female; Formaldehyde; Furocoumarins; Hot Temperature; Male; Medicine, Chinese Traditional; Mice; NAV1.7 Voltage-Gated Sodium Channel; Oleanolic Acid; Pain; Plant Roots; Saponins; Sodium | 2021 |
Effects of saikosaponin-d on CYP3A4 in HepaRG cell and protein-ligand docking study.
Topics: Bupleurum; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ligands; Molecular Docking Simulation; Oleanolic Acid; Saponins | 2021 |
Determination of Absolute Purities of Hygroscopic Substances by Quantitative NMR Analysis for the Standardization of Quantitative Reagents in the Japanese Pharmacopoeia (Part 2).
Topics: Anthracenes; Ginsenosides; Humidity; Hygroscopic Agents; Japan; Magnetic Resonance Spectroscopy; Oleanolic Acid; Saponins | 2021 |
Saikosaponin a contributed to CCIN treatment by promoting neutrophil bactericidal activity via activation CBL-dependent ERK pathway.
Topics: Blotting, Western; Cell Differentiation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Signaling System; Neutropenia; Neutrophils; Oleanolic Acid; Proto-Oncogene Proteins c-cbl; Saponins | 2021 |
Arenarosides A-G, Polyhydroxylated Oleanane-Type Saponins from
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Caryophyllaceae; Cell Line, Tumor; Humans; Oleanolic Acid; Phytochemicals; Plant Components, Aerial; Saponins; Vietnam | 2021 |
Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis.
Topics: COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Oleanolic Acid; Protein Domains; Saponins | 2021 |
Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway.
Topics: Animals; Antidepressive Agents; Apoptosis; Behavior, Animal; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Depression; Disease Models, Animal; Hippocampus; Ischemic Stroke; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Recovery of Function; Saponins | 2021 |
Saikosaponin-d increases radiation-induced apoptosis of hepatoma cells by promoting autophagy via inhibiting mTOR phosphorylation.
Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemoradiotherapy; Humans; Liver Neoplasms; Oleanolic Acid; Phosphorylation; Radiation Tolerance; Saponins; TOR Serine-Threonine Kinases | 2021 |
IL-6R blockade by chikusetsusaponin IVa butyl ester inhibits Th17 cell differentiation and ameliorates collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cell Differentiation; Cytokines; Mice; Oleanolic Acid; Receptors, Interleukin-6; Saponins; Th17 Cells | 2021 |
Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Esters; Female; Humans; Nanoparticles; Oleanolic Acid; Photochemotherapy; Photosensitizing Agents; Porphyrins; Saponins | 2021 |
Saikosaponin-d improved the stemness of mouse neural stem cells and increased their thermotolerance potential.
Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Female; Male; Mice; Neural Stem Cells; Neurogenesis; Oleanolic Acid; Saponins; Thermotolerance | 2021 |
Oleanane-type saponins and prosapogenins from Albizia julibrissin and their cytotoxic activities.
Topics: Albizzia; Antineoplastic Agents, Phytogenic; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 2021 |
Integrating non-targeted metabolomics and toxicology networks to study the mechanism of Esculentoside A-induced hepatotoxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Databases, Nucleic Acid; Male; Metabolic Networks and Pathways; Metabolomics; Oleanolic Acid; Rats; Rats, Wistar; Saponins | 2021 |
Facile Synthesis of Saikosaponins.
Topics: Glycosylation; Molecular Structure; Oleanolic Acid; Saponins | 2021 |
Ultra-high performance supercritical fluid chromatography method for separation and quantitation of saikosaponins in herbal medicine.
Topics: Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Drugs, Chinese Herbal; Herbal Medicine; Oleanolic Acid; Saponins | 2021 |
A hederagenin-type triterpene saponin, sumbulianoside a from
Topics: Dipsacaceae; HEK293 Cells; Humans; Influenza A Virus, H3N2 Subtype; Interleukin-4; Oleanolic Acid; Saponins; Seasons; Triterpenes | 2022 |
Production of Bioactive Deapiosylated Platycosides from Glycosylated Platycosides in Balloon Flower Root Using the Crude Enzyme from the Food-Available Fungus
Topics: Fungi; Glycosylation; Oleanolic Acid; Platycodon; Rhizopus; Rhizopus oryzae; Saponins | 2021 |
Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high-fat diet-fed mice.
Topics: 3T3-L1 Cells; Adipogenesis; Adipose Tissue; Animals; Anti-Obesity Agents; Cell Differentiation; Diet, High-Fat; Lipid Metabolism; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Saponins; Triglycerides | 2021 |
Synthesis and antitumor activity evaluation of oleanolic acid saponins bearing an acetylated l-arabinose moiety.
Topics: Acetylation; Antineoplastic Agents; Apoptosis; Arabinose; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Membrane Potential, Mitochondrial; Molecular Conformation; Oleanolic Acid; Saponins | 2021 |
Improved Bioactivity of 3-O-β-D-Glucopyranosyl Platycosides in Biotransformed
Topics: Anti-Inflammatory Agents; Antioxidants; Aspergillus; Biotransformation; Glycosylation; Monophenol Monooxygenase; Oleanolic Acid; Plant Roots; Platycodon; Polygalacturonase; Saponins | 2021 |
A novel acylated flavonol tetraglycoside and rare oleanane saponins with a unique acetal-linked dicarboxylic acid substituent from the xero-halophyte Bassia indica.
Topics: Acetals; Chenopodiaceae; Cholinesterase Inhibitors; Dicarboxylic Acids; Egypt; Flavonols; Glycosides; Molecular Structure; Oleanolic Acid; Phytochemicals; Plant Components, Aerial; Salt-Tolerant Plants; Saponins | 2021 |
A candidate gene identified in converting platycoside E to platycodin D from Platycodon grandiflorus by transcriptome and main metabolites analysis.
Topics: Gene Expression Profiling; Genes, Plant; Metabolomics; Oleanolic Acid; Platycodon; Saponins | 2021 |
Saikosaponin-d protects against liver fibrosis by regulating the estrogen receptor-β/NLRP3 inflammasome pathway.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Estrogen Receptor beta; Inflammasomes; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Protective Agents; Saponins | 2021 |
Identification of 3-
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Growth Inhibitors; Humans; Neoplastic Stem Cells; Oleanolic Acid; Saponins; Triterpenes | 2022 |
Comparative Quantitative Study of Ardisiacrispin A in Extracts from Ardisia crenata Sims Varieties and Their Cytotoxic Activities.
Topics: Antineoplastic Agents, Phytogenic; Ardisia; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins | 2021 |
Biosynthesis of Soyasapogenol B by Engineered Saccharomyces cerevisiae.
Topics: Fermentation; Oleanolic Acid; Saccharomyces cerevisiae; Saponins | 2021 |
A potential antiviral activity of Esculentoside A against binding interactions of SARS-COV-2 spike protein and angiotensin converting enzyme 2 (ACE2).
Topics: Angiotensin-Converting Enzyme 2; Antiviral Agents; Cell Line, Tumor; Coronavirus OC43, Human; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Oleanolic Acid; Saponins; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2021 |
Saikosaponins and the deglycosylated metabolites exert liver meridian guiding effect through PXR/CYP3A4 inhibition.
Topics: Bupleurum; Carcinoma, Hepatocellular; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Meridians; Microsomes, Liver; Oleanolic Acid; Pregnane X Receptor; Saponins; Time Factors | 2021 |
Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ginsenosides; Linear Models; Male; Oleanolic Acid; Rats; Rats, Wistar; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry | 2021 |
Glycosides of polygalacic acid from the stem barks of Piper guineense Schum and Thonn.
Topics: Glycosides; Oleanolic Acid; Piper; Saponins; Triterpenes | 2021 |
Topics: Caryophyllaceae; Cytochrome P-450 Enzyme System; Microorganisms, Genetically-Modified; Oleanolic Acid; Plant Proteins; Plants, Medicinal; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Saponins | 2021 |
Bioactive oleanane-type saponins from Hylomecon Japonica.
Topics: Magnetic Resonance Spectroscopy; Mass Spectrometry; Oleanolic Acid; Saponins; Triterpenes | 2021 |
Triterpenoid saponins and others glycosides from the stem barks of Pancovia turbinata Radlk.
Topics: Glycosides; Oleanolic Acid; Sapindaceae; Saponins | 2021 |
Calunduloside E inhibits HepG2 cell proliferation and migration via p38/JNK-HMGB1 signalling axis.
Topics: Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; HMGB1 Protein; Humans; Liver Neoplasms; MAP Kinase Signaling System; Oleanolic Acid; Phytotherapy; Saponins; Signal Transduction | 2021 |
Potent in vitro synergistic antibacterial activity of natural amphiphilic Sapindoside A and B against Cutibacterium acnes with destructive effect on bacterial membrane.
Topics: Anti-Bacterial Agents; Cell Wall; Drug Synergism; In Vitro Techniques; Membrane Proteins; Microbial Sensitivity Tests; Oleanolic Acid; Propionibacteriaceae; Saponins; Spectrum Analysis, Raman | 2021 |
Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Disease Models, Animal; Epithelial Cells; Hepatocyte Nuclear Factor 1-alpha; Humans; Inflammation; Kidney; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Nephritis; Oleanolic Acid; Proto-Oncogene Proteins c-fos; Saponins; Sepsis | 2021 |
Molecularly imprinted solid-phase extraction of Chikusetsu saponin IVa from Panacis majoris Rhizoma.
Topics: Chromatography, High Pressure Liquid; Molecular Imprinting; Oleanolic Acid; Panax; Reproducibility of Results; Rhizome; Saponins; Sensitivity and Specificity; Solid Phase Extraction | 2021 |
Synergistic Antioxidant Effects of Araloside A and L-Ascorbic Acid on H
Topics: Antioxidants; Ascorbic Acid; Drugs, Chinese Herbal; HEK293 Cells; Humans; Hydrogen Peroxide; Oleanolic Acid; Oxidative Stress; Saponins | 2021 |
Saikosaponin a promotes sleep by decreasing neuronal activities in the lateral hypothalamus.
Topics: Animals; Electroencephalography; Humans; Hypothalamic Area, Lateral; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Saponins; Sleep; Sleep Initiation and Maintenance Disorders | 2022 |
Antitumor Effect of Saikosaponin A on Human Neuroblastoma Cells.
Topics: Apoptosis; Bupleurum; Cell Line, Tumor; Cell Movement; Cell Proliferation; China; Humans; Inhibitory Concentration 50; Neuroblastoma; Oleanolic Acid; Plant Extracts; Saponins; Signal Transduction | 2021 |
Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Cycle Proteins; Cell Differentiation; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Humans; Interleukin-10; Janus Kinase 2; Membrane Transport Proteins; Mice; Oleanolic Acid; Phosphorylation; Protein Binding; Saponins; Signal Transduction; STAT3 Transcription Factor | 2021 |
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cells, Cultured; China; Fibrosis; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Receptors, Estrogen; Receptors, G-Protein-Coupled; Saponins; Signal Transduction; Transforming Growth Factor beta | 2021 |
[Chikusetsu saponin Ⅳa ameliorates myocardial hypertrophy of rats through regulating expression of miR199a-5p/Atg5].
Topics: Animals; Cardiomegaly; Isoproterenol; Myocardium; Myocytes, Cardiac; Oleanolic Acid; Rats; Saponins | 2021 |
Synergistic combination of Sapindoside A and B: A novel antibiofilm agent against Cutibacterium acnes.
Topics: Anti-Bacterial Agents; Biofilms; Drug Synergism; Molecular Docking Simulation; Oleanolic Acid; Propionibacteriaceae; Saponins | 2022 |
Anti-inflammatory and osteoprotective effects of Chikusetsusaponin Ⅳa on rheumatoid arthritis via the JAK/STAT signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Janus Kinases; Mice; Molecular Docking Simulation; Oleanolic Acid; Saponins; Signal Transduction | 2021 |
Saikosaponin A and D Inhibit Adipogenesis via the AMPK and MAPK Signaling Pathways in 3T3-L1 Adipocytes.
Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Adipogenesis; Adiponectin; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Bupleurum; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Gene Expression; Lipogenesis; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Obesity; Oleanolic Acid; Phosphorylation; Plant Extracts; PPAR gamma; Saponins; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2021 |
Topics: Antineoplastic Agents, Phytogenic; Hedyotis; Molecular Structure; Oleanolic Acid; Plant Components, Aerial; Rubiaceae; Saponins; Triterpenes | 2023 |
Dipsacoside B Exerts a Beneficial Effect on Brain Injury in the Ischemic Stroke Rat through Inhibition of Mitochondrial E3 Ubiquitin Ligase 1.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Brain Injuries; Hypoxia; Ischemic Stroke; Mitochondria; Mitochondrial Proteins; Oleanolic Acid; PC12 Cells; Rats; Rats, Sprague-Dawley; Saponins; Ubiquitin-Protein Ligases | 2022 |
Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca
Topics: Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Autophagy; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 2022 |
Transcriptome and metabolome analysis to reveal major genes of saikosaponin biosynthesis in Bupleurum chinense.
Topics: Bupleurum; Humans; Metabolome; Oleanolic Acid; Plant Roots; Saponins; Transcriptome | 2021 |
Pharmacological Approaches to Attenuate Inflammation and Obesity with Natural Products Formulations by Regulating the Associated Promoting Molecular Signaling Pathways.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Angiogenesis Inhibitors; Animals; Biological Products; Disease Models, Animal; Diterpenes, Kaurane; Drug Compounding; Drug Synergism; Female; Glucosides; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipid Metabolism; Lipogenesis; Lipolysis; Mice; Mice, Inbred ICR; Obesity; Oleanolic Acid; Phytotherapy; RNA, Messenger; Saponins; Signal Transduction; Stevia; Tea | 2021 |
Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study.
Topics: Amino Acid Motifs; Binding Sites; Cell Adhesion Molecules; Computer Simulation; COVID-19; Cytokines; Epitopes; Flavanones; Glucosides; Glycosides; Humans; Lectins, C-Type; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Monosaccharides; Oleanolic Acid; Polysaccharides; Receptors, Cell Surface; Saponins; Spike Glycoprotein, Coronavirus | 2021 |
Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway.
Topics: Animals; Anti-Inflammatory Agents; Bone Resorption; Cell Differentiation; Cells, Cultured; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Osteoclasts; Osteogenesis; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Saponins | 2021 |
Saikosaponin D Alleviates DOX-induced Cardiac Injury In Vivo and In Vitro.
Topics: Antioxidants; Apoptosis; Cardiotoxicity; Doxorubicin; Fibrosis; Humans; Myocytes, Cardiac; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Saponins | 2022 |
Saikosaponin-D Mitigates Oxidation in SH-SY5Y Cells Stimulated by Glutamate Through Activation of Nrf2 Pathway: Involvement of PI3K.
Topics: Apoptosis; Cell Line, Tumor; Glutamic Acid; Heme Oxygenase-1; Humans; Malondialdehyde; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Saponins; Signal Transduction | 2022 |
Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcium; Calcium Channels, L-Type; Myocardial Reperfusion Injury; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 2021 |
Development of Saikosaponin D Liposome Nanocarrier with Increased Hepatoprotective Effect Against Alcoholic Hepatitis Mice.
Topics: Animals; Hepatitis, Alcoholic; Liposomes; Mice; Oleanolic Acid; Saponins | 2021 |
Cytotoxic 13,28 Epoxy Bridged Oleanane-Type Triterpenoid Saponins from the Roots of
Topics: Antineoplastic Agents, Phytogenic; Ardisia; Epoxy Compounds; Humans; Neoplasms; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Triterpenes; Tumor Cells, Cultured | 2022 |
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway.
Topics: Allografts; Animals; Cerebellar Neoplasms; Hedgehog Proteins; Medulloblastoma; Mice; Oleanolic Acid; Saponins; Signal Transduction; Zinc Finger Protein GLI1 | 2022 |
Utility of the combination of hederagenin glucoside saponins and chromane hydrazone in the topical treatment of canine cutaneous leishmaniasis. An observational study.
Topics: Animals; Antiprotozoal Agents; Dogs; Female; Glucosides; Hydrazones; Leishmaniasis, Cutaneous; Male; Mice; Ointments; Oleanolic Acid; Saponins; Swine | 2022 |
Phytochemical profile of Centevita®, a Centella asiatica leaves extract, and isolation of a new oleanane-type saponin.
Topics: Centella; Molecular Structure; Oleanolic Acid; Phytochemicals; Plant Extracts; Plant Leaves; Saponins; Triterpenes | 2022 |
Active microbial metabolites study on antitussive and expectorant effects and metabolic mechanisms of platycosides fraction of Platycodonis Radix.
Topics: Animals; Antitussive Agents; Chromatography, Liquid; Expectorants; Gastrointestinal Microbiome; Metabolome; Metabolomics; Mice; Oleanolic Acid; Plant Extracts; Platycodon; Saponins | 2022 |
α-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Molecular Docking Simulation; Neoplasm Metastasis; Oleanolic Acid; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Saponins; Signal Transduction; STAT3 Transcription Factor | 2022 |
Oleanane-type glycosides isolated from the trunk barks of the Central African tree Millettia laurentii.
Topics: Animals; Glycosides; Mice; Millettia; Molecular Structure; Oleanolic Acid; Saponins; Trees | 2022 |
Overexpression of BcERF3 increases the biosynthesis of saikosaponins in Bupleurum chinense.
Topics: Bupleurum; Oleanolic Acid; Plant Roots; Saponins | 2022 |
Chemical synthesis of the pentasaccharide related to the anti-inflammatory oleanane type saponins isolated from medicinal plant Aster tataricus L. f.
Topics: Anti-Inflammatory Agents; Glycosides; Oleanolic Acid; Oligosaccharides; Plants, Medicinal; Saponins | 2022 |
Saikosaponin A Inhibits Growth of Human Bladder Carcinoma T24 and 5637 Cells Both in Vitro and in Vivo.
Topics: Animals; Apoptosis; Bisbenzimidazole; Carcinoma; Caspases; Cell Line, Tumor; Cell Proliferation; Humans; Mice; Oleanolic Acid; Saponins; Urinary Bladder; Urinary Bladder Neoplasms | 2022 |
Saikosaponin A and Saikosaponin C Reduce TNF-α-Induced TSLP Expression through Inhibition of MAPK-Mediated EGR1 Expression in HaCaT Keratinocytes.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Atopic; Early Growth Response Protein 1; HaCaT Cells; Humans; Keratinocytes; Mice; Oleanolic Acid; Saponins; Skin Diseases; Thymic Stromal Lymphopoietin; Tumor Necrosis Factor-alpha | 2022 |
Production of Prosaikogenin F, Prosaikogenin G, Saikogenin F and Saikogenin G by the Recombinant Enzymatic Hydrolysis of Saikosaponin and their Anti-Cancer Effect.
Topics: Humans; Hydrolysis; Oleanolic Acid; Sapogenins; Saponins | 2022 |
Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway.
Topics: Animals; Diet, High-Fat; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleanolic Acid; PPAR alpha; Saponins; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2022 |
Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Cytochromes c; Glucose; Mice; Mitochondria; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Reperfusion Injury; Saponins | 2022 |
Undescribed glucosylceramide, flavonol triglycoside, and oleanane saponin from the halophyte Agathophora alopecuroides: Promising candidates for stimulating ceramide synthesis.
Topics: Chenopodiaceae; Flavonols; Glucosylceramides; Oleanolic Acid; Plant Extracts; Salt-Tolerant Plants; Saponins; Triterpenes | 2022 |
Anti-Colon Cancer Activity of Dietary Phytochemical Soyasaponin I and the Induction of Metabolic Shifts in HCT116.
Topics: Colonic Neoplasms; Humans; Molecular Docking Simulation; Oleanolic Acid; Phytochemicals; Saponins | 2022 |
Metabolic profiling of soyasaponin Bb in rat plasma, urine, bile, and feces after intragastric administration.
Topics: Administration, Oral; Animals; Antioxidants; Bile; Chromatography, High Pressure Liquid; Feces; Oleanolic Acid; Rats; Saponins | 2022 |
Effects of Triterpene Soyasapogenol B from
Topics: Arachis; Autophagy; Cell Differentiation; Cell Line; Necroptosis; Oleanolic Acid; Osteoblasts; Saponins; Triterpenes | 2022 |
Synergistic neuroprotective effect of saikosaponin A and albiflorin on corticosterone-induced apoptosis in PC12 cells via regulation of metabolic disorders and neuroinflammation.
Topics: Animals; Apoptosis; Bridged-Ring Compounds; Corticosterone; Humans; Metabolic Diseases; Neuroinflammatory Diseases; Neuroprotective Agents; Oleanolic Acid; PC12 Cells; Purines; Rats; Saponins | 2022 |
Drought Stress Stimulates the Terpenoid Backbone and Triterpenoid Biosynthesis Pathway to Promote the Synthesis of Saikosaponin in
Topics: Bupleurum; Droughts; Oleanolic Acid; Plant Roots; Saponins; Terpenes | 2022 |
Hederagenin ameliorates cisplatin-induced acute kidney injury via inhibiting long non-coding RNA A330074k22Rik/Axin2/β-catenin signalling pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; beta Catenin; Cisplatin; Disease Models, Animal; Inflammation; Kidney; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Oleanolic Acid; RNA, Long Noncoding; RNA, Messenger; RNA, Small Interfering; Saponins | 2022 |
[Simultaneous determination and pharmacokinetic study of five compounds from total extract of Clinopodium chinense in abnormal uterine bleeding rat plasma by UPLC-MS/MS].
Topics: Administration, Oral; Animals; Apigenin; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drugs, Chinese Herbal; Female; Flavonoids; Hesperidin; Lamiaceae; Mifepristone; Misoprostol; Oleanolic Acid; Plant Extracts; Rats; Saponins; Tandem Mass Spectrometry; Uterine Hemorrhage | 2022 |
Discovery and structural optimization of 3-O-β-Chacotriosyl betulonic acid saponins as potent fusion inhibitors of Omicron virus infections.
Topics: COVID-19; HIV Fusion Inhibitors; Humans; Oleanolic Acid; Saponins; SARS-CoV-2; Virus Diseases | 2023 |
Saikosaponin A and Its Epimers Alleviate LPS-Induced Acute Lung Injury in Mice.
Topics: Acetic Acid; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Interleukin-6; Lipopolysaccharides; Mice; NF-kappa B; Oleanolic Acid; Saponins; Tumor Necrosis Factor-alpha | 2023 |
Soyasaponin I alleviates hypertensive intracerebral hemorrhage by inhibiting the renin-angiotensin-aldosterone system.
Topics: Animals; Intracranial Hemorrhage, Hypertensive; Oleanolic Acid; Rats; Renin-Angiotensin System; Saponins | 2023 |
Five New Oleanane Triterpene Saponins from Camellia petelotii and Their Alpha-glucosidase Inhibitory Activity.
Topics: alpha-Glucosidases; Camellia; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 2023 |
Saikosaponin D exerts cytotoxicity on human endometrial cancer ishikawa cells by inducing apoptosis and inhibiting metastasis through MAPK pathways.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Female; HEK293 Cells; Humans; Oleanolic Acid; Saponins | 2023 |
[Correlations between appearance traits and internal quality of Bupleurum scorzonerifolium roots based on theory of "quality evaluation through morphological identification"].
Topics: Bupleurum; Oils, Volatile; Oleanolic Acid; Plant Roots; Saponins | 2023 |
Oleanolic Acid Glycosides from
Topics: Animals; Caprifoliaceae; Dipsacaceae; Glycosides; Mice; Oleanolic Acid; Saponins; Triterpenes | 2023 |
Comparative genomics of the medicinal plants Lonicera macranthoides and L. japonica provides insight into genus genome evolution and hederagenin-based saponin biosynthesis.
Topics: COVID-19; Evolution, Molecular; Genomics; Humans; Lonicera; Oleanolic Acid; Plants, Medicinal; Saponins | 2023 |
Quantitative and Differential Analysis between
Topics: Bupleurum; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Mass Spectrometry; Oils, Volatile; Oleanolic Acid; Plant Roots; Saponins | 2023 |
Cytotoxic triterpenoid saponins from the root of Olax subscorpioidea Oliv. (Olacaceae).
Topics: Antineoplastic Agents; Caco-2 Cells; HeLa Cells; Humans; Olacaceae; Oleanolic Acid; Saponins; Triterpenes; Vincristine | 2023 |
The Equilibria of Triterpene Sapogenins-Phosphatidylcholine in Monolayers at the Air/Water Interface.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Lecithins; Oleanolic Acid; Sapogenins; Saponins; Surface Properties; Triterpenes; Water | 2023 |