oleanolic acid has been researched along with bardoxolone methyl in 207 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.48) | 18.2507 |
| 2000's | 28 (13.53) | 29.6817 |
| 2010's | 150 (72.46) | 24.3611 |
| 2020's | 28 (13.53) | 2.80 |
| Authors | Studies |
|---|---|
| Bore, L; Favaloro, FG; Gribble, GW; Honda, T; Rounds, BV; Spor, MB; Suh, N; Wang, Y | 1 |
| Bore, L; Favaloro, FG; Finlay, HJ; Gribble, GW; Honda, T; Rounds, BV; Sporn, MB; Suh, N; Wang, Y | 1 |
| Favaloro, FG; Gribble, GW; Honda, T; Honda, Y; Place, AE; Rendi, MH; Sporn, MB; Suh, N | 1 |
| Berry, NG; Bibby, J; Bryan, HK; Chiu, PH; Copple, IM; Goldring, CE; Jenkins, RE; Kitteringham, NR; O'Neill, PM; Park, BK; Wong, MH | 1 |
| Appendino, G; Bellido, ML; Cruz, C; Del Prete, D; Minassi, A; Muñoz, E; Sirignano, C; Taglialatela-Scafati, O | 1 |
| Alho, DPS; Figueiredo, SAC; Gonçalves, BMF; Leal, AS; Mendes, VIS; Salvador, JAR; Silvestre, SM; Valdeira, AS | 1 |
| Huang, J; Ma, H; Wang, Y; Wang, Z; Yao, Z; Yu, J; Zhang, L; Zhang, W; Zhuang, C | 1 |
| Andreeff, M; Chang, S; Estrov, Z; Gribble, G; Harris, D; Honda, T; Jackson, CE; Konopleva, M; Leysath, CE; May, WS; Munsell, M; Ruvolo, P; Sporn, MB; Stiouf, I; Suh, N; Tsao, T; Zhao, S | 1 |
| Bore, L; Gribble, GW; Honda, T; Jasinski, JP; Lork, E | 1 |
| Gribble, GW; Honda, T; Hong, WK; Kim, KB; Lotan, R; Sporn, MB; Suh, N; Sun, SY; Wu, GS; Yue, P | 1 |
| Andreeff, M; Kim, YS; Kitada, S; Minden, M; Reed, JC; Schimmer, AD; Sporn, M; Suh, N; Suh, WS | 1 |
| Khuri, FR; Liu, X; Lotan, R; Sporn, MB; Sun, SY; Yue, P; Zhou, Z; Zou, W | 1 |
| Andreeff, M; Chen, W; Contractor, R; Konopleva, M; Kurinna, SM; Ruvolo, PP | 1 |
| Aggarwal, BB; Andreeff, M; Konopleva, M; Sethi, G; Shishodia, S | 1 |
| Khuri, FR; Sun, SY; Yue, P; Zhou, Z | 1 |
| Ahmad, R; Kharbanda, S; Kufe, D; Meyer, C; Raina, D | 1 |
| Deeb, D; Dulchavsky, SA; Gao, X; Gautam, SC; Jiang, H; Liu, Y | 1 |
| Dmitrovsky, E; Gribble, GW; Honda, T; Liby, K; Risingsong, R; Royce, DB; Sporn, MB; Sporn, TA; Williams, CR; Yore, MM | 1 |
| Andreeff, M; Dietrich, M; Konopleva, M; Ling, X; Madden, TL; McQueen, T; Ruvolo, V; Schober, W; Stephens, LC; Zeng, Z | 1 |
| Biswal, S; Bream, JH; Fuchs, RJ; Kensler, TW; Liby, KT; Malhotra, D; Scollick, C; Sporn, MB; Thimmulappa, RK; Traore, K; Trush, MA | 1 |
| Andreeff, M; Bielawski, J; Kong, G; Konopleva, M; Maurer, BJ; Ruvolo, PP; Wang, D; Wang, H; Wu, J | 1 |
| Albini, A; Barberis, M; Cammarota, R; Lorusso, G; Noonan, DM; Sporn, MB; Vannini, N | 1 |
| Andreeff, M; Contractor, R; Issa, JP; Kogan, SC; Kondo, Y; Konoplev, S; Konopleva, M; Ling, X; Nagaoka, I; Ohsaka, A; Shi, Y; Tabe, Y; Tsao, T; Tsutsumi-Ishii, Y; Watt, JC | 1 |
| Chen, S; Khuri, FR; Liu, X; Sporn, MB; Sun, SY; Yue, P; Zou, W | 1 |
| Ahmad, R; Kufe, D; Meyer, C; Raina, D | 1 |
| McCoy, MK; Sporn, MB; Tansey, MG; Tran, TA | 1 |
| Andreeff, M; Beran, M; Dunner, K; Kantarjian, H; Kondo, S; Konopleva, M; Korchin, B; Kurinna, S; Ruvolo, P; Samudio, I | 1 |
| Ames, RY; Duan, Z; Hornicek, FJ; Mankin, H; Ryan, M; Seiden, MV | 1 |
| Danyluk, A; Deeb, D; Dulchavsky, SA; Gao, X; Gautam, SC; Liu, Y; Media, J | 1 |
| Albini, A; Gribble, GW; Honda, T; Lamph, WW; Liby, K; Risingsong, R; Royce, DB; Sogno, I; Sporn, MB; Vannini, N; Williams, CR; Yore, MM | 1 |
| Khuri, FR; Sun, SY; Yue, P; Zou, W | 1 |
| Deeb, D; Dulchavsky, SA; Gao, X; Gautam, SC; Jiang, H | 1 |
| Arbab, AS; Deeb, D; Dulchavsky, SA; Gao, X; Gautam, SC; Janic, B; Jiang, H; Rojanasakul, Y | 1 |
| Liby, K; Ma, T; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR; Yore, MM | 1 |
| Choy, E; Duan, Z; Hornicek, FJ; Mankin, H; Ryu, K; Susa, M; Yang, C | 1 |
| Antonia, S; Becerra, CR; Cotter, MJ; Fishman, M; Gabrilovich, DI; Iclozan, C; Lee, JH; Liby, KT; Lu, L; Meyer, C; Nagaraj, S; Rawal, B; Sporn, MB; Weber, H; Youn, JI | 1 |
| Li, M; Murphy, WJ; Redelman, D; Sun, K; Welniak, LA | 1 |
| Choy, E; Duan, Z; Hornicek, FJ; Mankin, H; Schwab, JH; Wood, KB; Yang, C | 1 |
| Arbab, AS; Deeb, D; Dulchavsky, SA; Gao, X; Gautam, SC; Hao, J; Liu, Y | 1 |
| Choy, E; Duan, Z; Hornicek, FJ; Mankin, HJ; Ryu, K; Susa, M; Yang, C | 1 |
| Abdelrahim, M; Andreeff, M; Basha, MR; Chadalapaka, G; Jutooru, I; Konopleva, M; Safe, S; Samudio, I | 1 |
| Bauerle, KT; Haugen, BR; Schweppe, RE | 1 |
| Di Guglielmo, GM; Shilton, BH; To, C | 1 |
| Ahmad, R; Galinsky, I; Kharbanda, S; Kufe, D; Liu, S; Meyer, C; Nelson, E; Stone, R; Weisberg, E | 1 |
| Alabran, JL; Auletta, JJ; Kim, BG; Letterio, JJ; Meyer, CJ | 1 |
| Batten, K; Cornelius, C; Eskiocak, U; Kim, SB; Kitten, E; Roig, AI; Shay, JW; Wright, WE; Zou, YS | 1 |
| Andreeff, M; Chan, L; Konopleva, M; Reddy, VT; Saha, PK | 1 |
| Hruban, RH; Liby, KT; Maitra, A; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR | 1 |
| Agarwal, A; Chen, B; Chen, J; Ferguson, DA; Grossman, E; Hartono, J; Lu, CY; Meyer, C; Senitko, M; Wang, Y; Wigley, WC; Winterberg, P; Wu, QQ; Zhou, XJ | 1 |
| Ferguson, DA; Huff, JW; Krauth, M; Meyer, CJ; Pergola, PE; Ruiz, S; Warnock, DG | 1 |
| Duh, EJ; Eberhart, CG; Gong, J; Handa, JT; Kombairaju, P; Sporn, MB; Wei, Y; Xu, Z; Yoshida, T | 1 |
| Arbab-Ali, S; Deeb, D; Dulchavsky, SA; Gao, X; Gautam, SC; Liu, P; Liu, Y | 1 |
| Audhya, P; Christ-Schmidt, H; Grossman, EB; Huff, JW; Krauth, M; Meyer, CJ; Pergola, PE; Raskin, P; Ruiz, S; Toto, RD; Warnock, DG; Wittes, J | 1 |
| Abel, EL; Andreeff, M; Bubel, JD; DiGiovanni, J; MacLeod, MC; McClellan, SA; Powell, L; Simper, MS | 1 |
| Cooper, ME; Thomas, MC | 1 |
| Thomas, MC | 1 |
| Deng, C; Kim, EH; Liby, KT; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR | 1 |
| Gupta, A; Khaira, A | 1 |
| Ames, E; Harouna, S; Meyer, C; Murphy, WJ; Welniak, LA | 1 |
| Arbab, AS; Deeb, D; Dulchavsky, SA; Gao, X; Gautam, SC; Guo, AM; Liu, Y | 1 |
| Abramowitz, MK; Bauer, C; Hostetter, TH; Melamed, ML; Turner, JM | 1 |
| Deeb, D; Gao, X; Gautam, SC; Liu, Y | 1 |
| Feldon, SE; Hindman, HB; Huxlin, KR; Kulkarni, AA; Kuriyan, AE; Lehmann, GM; Phipps, RP; Sime, PJ; Woeller, CF | 1 |
| Crunkhorn, S | 1 |
| Boffa, JJ; Chatziantoniou, C; Dussaule, JC; Ronco, P | 1 |
| Goossens, A; Pollier, J | 1 |
| Merk, D; Schubert-Zsilavecz, M | 1 |
| Liby, K; Risingsong, R; Royce, D; Sporn, MB; Tran, K; Williams, CR | 1 |
| Bliska, JB; Bumeister, R; David, E; Dinkova-Kostova, AT; Honda, T; Mierke, DF; Ojima, I; Ren, Y; Santosh Laxmi, YR; Shiavoni, KH; Trevino, I; Wigley, WC; Zheng, S; Zheng, Y | 1 |
| Arbab, AS; Deeb, D; Gao, X; Gautam, SC; Kim, SH; Liu, Y; Pindolia, KR | 1 |
| Andreeff, M; Dezube, BJ; Eder, JP; Ferguson, DA; He, X; Hong, DS; Konoplev, S; Konopleva, M; Kufe, D; Kurzrock, R; Lawrence, D; Lazarus, H; Meyer, CJ; Mier, J; Naing, A; Shapiro, GI; Supko, JG; Wheler, J | 1 |
| Bargman, J; Burkart, J; Chertow, GM; Davies, S; Finkelstein, FO; Hebbar, S; Mehrotra, R; Ronco, C; Teitelbaum, I; Urakpo, K; Warnock, DG | 1 |
| Thomas, M | 1 |
| Ali, S; McCullough, PA | 1 |
| Chertow, GM; Hebbar, S; Meyer, CJ; Reisman, SA; Vaziri, ND; Ward, KW | 1 |
| Deeb, D; Gao, X; Gautam, SC; Liu, YB | 1 |
| Klein, JB; Lederer, ED | 1 |
| Deng, W; Ekmekcioglu, S; Grimm, EA; Qin, Y | 1 |
| Hohenstein, B; Hugo, C | 1 |
| Abbate, M; Benigni, A; Carrara, F; Corna, D; Gaspari, F; Locatelli, M; Nava, V; Remuzzi, G; Sangalli, F; Zoja, C | 1 |
| Zhang, DD | 1 |
| Arbab, AS; Deeb, D; Gao, X; Gautam, SC; Liu, A; Liu, P; Liu, Y | 1 |
| Pergola, PE; Ruiz, S; Vaziri, ND; Zager, RA | 1 |
| Saito, H | 1 |
| Rossing, P | 1 |
| Kalantar-Zadeh, K; Tayek, JA | 1 |
| Agarwal, R; Akizawa, T; Audhya, P; Bakris, GL; Chertow, GM; Chin, M; de Zeeuw, D; Krauth, M; Lambers Heerspink, HJ; McMurray, JJ; Meyer, CJ; Parving, HH; Pergola, PE; Remuzzi, G; Toto, RD; Vaziri, ND; Wanner, C; Warnock, DG; Wittes, J | 1 |
| Arbab, AS; Deeb, D; Gao, X; Gautam, SC; Liu, Y; Varma, NR | 1 |
| Arbab, AS; Deeb, D; Gao, X; Gautam, SC; Liu, Y | 1 |
| Fu, L; Gribble, GW | 1 |
| Appel, G | 1 |
| Bumeister, R; Chin, M; Chuang, JC; Lee, CY; Meyer, C; Sonis, ST; Ward, KW; Wigley, WC | 1 |
| Hsiao, HM; Kottmann, RM; Kulkarni, AA; Morrissette, J; Olsen, KC; Phipps, RP; Sime, PJ; Thatcher, TH; Wright, TW | 1 |
| Akizawa, T; Audhya, P; Bakris, GL; Chertow, GM; Christ-Schmidt, H; de Zeeuw, D; Goldsberry, A; Krauth, M; Lambers Heerspink, HJ; Linde, P; McMurray, JJ; Meyer, CJ; Parving, HH; Remuzzi, G; Toto, RD; Vaziri, ND; Wanner, C; Wittes, J; Wrolstad, D | 1 |
| Akizawa, T; Audhya, P; Bakris, GL; Chertow, GM; Chin, M; Christ-Schmidt, H; de Zeeuw, D; Goldsberry, A; Houser, M; Krauth, M; Lambers Heerspink, HJ; McMurray, JJ; Meyer, CJ; Parving, HH; Remuzzi, G; Toto, RD; Vaziri, ND; Wanner, C; Wittes, J; Wrolstad, D | 1 |
| Himmelfarb, J; Tuttle, KR | 1 |
| Cao, M; Fu, L; Gribble, GW; Liby, KT; Onyango, EO; Sporn, MB | 1 |
| Chen, W; Fan, J; Feng, X; Liu, X; Wang, J; Wu, J; Yang, X; Yu, X; Zeng, Y | 1 |
| Wang, YY; Zhao, R; Zhe, H | 1 |
| Goldsmith, DJ; Hajhosseiny, R; Jivraj, N; Khavandi, K; Malik, RA; Mashayekhi, S | 1 |
| de Haan, JB; Tan, SM | 1 |
| Attley, J; Cuzzocrea, S; Esposito, E; Impellizzeri, D | 1 |
| Hara, H; Iwama, T; Iwawaki, T; Kitashoji, A; Shimazawa, M; Takagi, T; Tsuruma, K; Yoshimura, S | 1 |
| Choi, SH; Fink, S; Kim, BG; Letterio, JJ; Markowitz, SD; Robinson, J; Sporn, MB; Yan, M | 1 |
| Copple, I; Goldring, CE; Jenkins, RE; Kitteringham, NR; O'Neill, PM; Olayanju, A; Park, BK; Powell, H; Walsh, J; Wong, M | 1 |
| Bakris, GL; Chin, MP; Linde, PG; McCullough, PA; Meyer, CJ; O'Grady, M; Packham, D; Reisman, SA; Vaziri, ND; Ward, KW; Warnock, DG | 1 |
| Andreeff, M; Hemachandran, S; Khobahy, E; Min, SY; Mohan, C; Pathak, S; Wu, T; Yan, M; Ye, Y; Zhou, J; Zhou, XJ; Zhu, J | 1 |
| Kitsukawa, M; Maeda, A; Miyamoto, Y; Oshida, K; Tsuchiyama, H | 1 |
| Fuchs, RJ; Navas-Acien, A; Noel, S; Zheng, L | 1 |
| Bakris, GL; Chertow, GM; Chin, MP; de Zeeuw, D; Goldsberry, A; Linde, PG; McCullough, PA; McMurray, JJ; Meyer, CJ; Wittes, J; Wrolstad, D | 1 |
| Camer, D; Huang, XF | 1 |
| He, ZX; Wang, YY; Yang, YX; Zhe, H; Zhou, SF | 1 |
| Cardentey, A; Delgado, O; El-Ashmawy, M; Shay, JW; Wright, WE | 1 |
| Camer, D; Dinh, CHL; Fernandez, F; Huang, XF; Szabo, A; Yu, Y | 1 |
| Chen, T; Huang, Z; Ji, H; Mou, Y; Peng, S; Qiao, Y; Tan, J; Wei, L; Wei, T; Xiang, P; Zhang, Y | 1 |
| Camer, D; Dinh, CH; Huang, XF; Szabo, A; Wang, H; Yu, Y | 4 |
| Duan, W; He, ZX; Pan, ST; Qiu, JX; Wang, YY; Yang, T; Yang, YX; Zhang, X; Zhao, R; Zhe, H; Zhou, SF | 1 |
| Bowman, PD; Bynum, JA; Rastogi, A; Stavchansky, SA | 1 |
| Liby, KT; Ringelberg, CS; Risingsong, R; Royce, DB; Sporn, MB; To, C; Williams, CR | 1 |
| Camer, D; Cheng, L; Dinh, CH; Huang, XF; Szabo, A; Wang, H; Yu, Y | 1 |
| Cho, H; Choi, KS; Jeong, SA; Kim, IY; Lee, AR; Lee, JS; Yoon, MJ | 1 |
| Camer, D; Dinh, CH; Huang, XF; Szabo, A; Wang, H; Yu, Y; Zhang, Q | 1 |
| He, ZX; Ma, YQ; Wang, YY; Zhang, CY; Zhe, H; Zhou, SF | 1 |
| Gao, FH; Lei, H; Ma, CM; Qin, DJ; Tang, CX; Wang, YY; Wei, W; Wu, YL; Xu, HZ; Yang, L | 1 |
| Huang, L; Huo, M; Wang, Y; Xu, Z; Zhao, Y | 1 |
| Bartolomeo, R; Carnevale, G; Cormio, A; Cossarizza, A; De Biasi, S; De Pol, A; Gibellini, L; Musicco, C; Nasi, M; Pecorini, S; Pinti, M | 1 |
| Deeb, D; Gao, X; Gautam, SC; Liu, P; Liu, Y; Shaw, J; Zhang, Y | 1 |
| Akcilar, R; Aras, B; Bayat, Z; Kocak, C; Kocak, FE; Metineren, MH; Simsek, H; Yucel, M | 1 |
| Hara, H; Imai, T; Kitashoji, A; Shimazawa, M; Takagi, T; Yamauchi, K | 1 |
| Ball, MS; Kim, H; Liby, KT; Pioli, PA; Shipman, EP | 1 |
| Dinh, CH; Huang, XF; Szabo, A; Yu, Y; Zhang, P; Zhang, Q | 1 |
| Awni, WM; Dumas, EO; Kelley, RJ; Klein, CE; Meyer, CJ; Teuscher, NS | 1 |
| Ji, JA; Jiang, ZY; Lu, MC; You, QD | 1 |
| Aleksunes, LM; Atilano-Roque, A; Joy, MS | 1 |
| Cai, H; Gao, F; Jin, J; Lei, H; Luo, H; Ma, C; Qin, D; Tang, C; Wang, T; Wang, W; Wang, Y; Wu, Y; Wu, YL; Xiao, W; Xu, H; Zhang, J | 1 |
| Chen, D; Kong, L; Sun, H; Sun, Y; Wang, P; Wen, X; Zhang, C; Zhang, J; Zhang, P | 1 |
| Akçılar, A; Akçılar, R; Dodurga, Y; Elmas, L; Güçlü, A; Koçak, C; Koçak, FE | 1 |
| Breyer, MD; Susztak, K | 1 |
| Adcott, J; Bertrand, HC; Callard, R; Castillo-Quan, JI; Cochemé, HM; Gatliff, J; Gomez Perez-Nievas, B; Ivanov, DK; Kerr, F; Khericha, M; Martinez, P; Noble, W; Partridge, L; Snoeren, I; Sofola-Adesakin, O; Thornton, J; Wells, G | 1 |
| Anderson, EL; Iijima, K; Kita, H; Maniak, PJ; O'Grady, SM; Patil, N; Squillace, DL; Uchida, M | 1 |
| Cheng, Y; Jin, UH; Safe, S; Zhou, B | 1 |
| Ali, SS; Arif, M; Brown, JE; Carmichael, A; Griffiths, HR; Pararasa, C; Refaat, A; Sakurai, H | 1 |
| Bhindi, R; Birgisdottir, AB; Bubb, KJ; Figtree, GA; Hansen, T; Karimi Galougahi, K; Kok, C; Meyer, C; Rasko, NB; Reisman, SA; Ritchie, R; Tang, O; Ward, K | 1 |
| Nezu, M; Suzuki, N; Yamamoto, M | 1 |
| Hisamichi, M; Hoshino, S; Kamijo-Ikemori, A; Kimura, K; Shibagaki, Y; Sugaya, T | 1 |
| Chen, C; Huang, Z; Lai, Y; Li, P; Mou, Y; Peng, S; Tian, J; Xu, X; Xu, Y; Zhang, Y; Zhao, D | 1 |
| Toto, RD | 1 |
| Baigent, C; Lennon, R | 1 |
| Chen, X; Cheng, Y; Gong, Y; Huang, Z; Kong, H; Li, H; Mou, Y; Qian, S; Wang, H; Xie, W; Zhang, Y | 1 |
| Bakris, GL; Block, GA; Chertow, GM; Chin, MP; Goldsberry, A; Heerspink, HJL; Inker, LA; Meyer, CJ; O'Grady, M; Pergola, PE; Wanner, C; Warnock, DG | 1 |
| Chaudhari, N; Ravanan, P | 1 |
| Choi, J; Gee, MS; Inn, KS; Kang, SB; Kim, BJ; Kim, N; Kim, NJ; Lee, JK | 1 |
| Mashino, T; Obata, R; Ohe, T; Takahashi, K; Yasuda, D | 1 |
| Abdel-Mageed, AB; Braun, SE; Chandra, PK; Gerlach, SL; Khurana, N; Li, J; Mondal, D; Swientoniewski, LT; Wu, C | 1 |
| Appel, GB; Block, GA; Chertow, GM; Chin, MP; Coyne, DW; Goldsberry, A; Kalantar-Zadeh, K; Meyer, CJ; Molitch, ME; Pergola, PE; Raskin, P; Rossing, P; Silva, AL; Spinowitz, B; Sprague, SM | 1 |
| Chawla-Sarkar, M; Mukherjee, A; Mukhopadhyay, U; Patra, U; Sarkar, R | 1 |
| Bishayee, A; Deshmukh, RR; Kumar, P; Kumar, S; Sharma, H | 1 |
| Bentley, RA; Colley, HE; Copple, IM; Cross, MJ; Lu, ZQ; Murdoch, C; Sharma, P; Tomlinson, L; Webb, SD | 1 |
| Chang, E; Han, L; Hu, X; Ko, CC; Kwon, J; Lee, DJ; Nay, N; Powers, J; Tseng, H; Wong, SW; Wu, TH; Xue, P | 1 |
| Basagni, F; Lanni, C; Minarini, A; Rosini, M | 1 |
| Hara, H; Hida, Y; Horai, N; Inoue, Y; Masuda, T; Nakagami, Y; Nakamura, S; Nishinaka, A; Noguchi, T; Sakurai, S; Shimazawa, M; Tsusaki, H | 1 |
| Ku, SK; Kwak, MK; Lee, JH; Lee, SH; Ryoo, IG; Song, MK | 1 |
| Chin, MP; Goldsberry, A; Meyer, CJ; O Apos Grady, M; Rich, S | 1 |
| Chin, MP; Goldsberry, A; McCullough, PA; Meyer, CJ; O'Grady, M; Pergola, PE; Rizk, DV; Silva, AL; Toto, R; Warnock, DG | 1 |
| Akahori, Y; Hasegawa, H; Hijikata, M; Nio, Y; Okamura, H; Oshima, M; Ryo, A; Sasai, M; Tanaka, Y; Wakita, T; Watashi, K | 1 |
| Chen, HM; Pei, X; Zhang, XJ | 1 |
| Solomon, R | 1 |
| Block, GA; Chertow, GM; Chin, MP; Goldsberry, A; Heerspink, HJL; McCullough, PA; Meyer, CJ; Packham, D; Pergola, PE; Rossing, P; Spinowitz, B; Sprague, SM; Warnock, DG | 1 |
| Choi, SH; Kang, TC; Kim, JE; Kong, MJ; Park, H | 1 |
| Fang, S; Hang, J; Henderson, MJ; Rothan, HA; Ruan, J; Sanborn, MA; Teoh, TC; Yusof, R; Zhong, Y | 1 |
| Kadıoğlu, E; Koçak, C; Koçak, FE; Tekşen, Y | 1 |
| Ding, D; Gai, C; Li, W; Li, Z; Lv, S; Wang, Y; Yu, M; Zhang, W; Zheng, J | 1 |
| Ito, M; Nangaku, M | 1 |
| Choi, SH; Kang, TC; Kim, JE; Kim, MJ; Kong, MJ; Park, H | 1 |
| Capolongo, G; Celentano, S; Pollastro, RM | 1 |
| Gao, L; Hackfort, BT; Tian, C; Zhang, A; Zucker, IH | 1 |
| Anwar, B; Argus, J; Blair, IA; Bowlin, S; Kamel, AM; Reichard, H | 1 |
| Akalin, A; Boltengagen, A; Bosse, J; Franke, V; Grässer, F; Kocks, C; Landthaler, M; Menegatti, J; Praktiknjo, S; Rajewsky, N; Walch-Rückheim, B; Wyler, E | 1 |
| Borella, R; Cossarizza, A; De Biasi, S; De Gaetano, A; Forti, L; Gibellini, L; Nasi, M; Pinti, M | 1 |
| Encinar, JA; Galiano, V; Villalaín, J | 1 |
| Chan, E; Cino, EA; Di Guglielmo, GM; Soares, IN; Thai, B; Trelford, CB; Viana, R | 1 |
| Archambault, K; Ball, MS; Bhandari, R; ElTanbouly, MA; Liby, KT; Martyanov, V; Pioli, PA; Torres, GM; Whitfield, ML | 1 |
| Kang, TC; Kim, JE; Lee, JE; Park, H | 1 |
| Beinke, C; Eder, S; Hermann, C; Popp, T; Port, M; Scherthan, H | 1 |
| Dong, MJ; Liu, YY; Mao, L; Sun, MY; Tang, S; Yang, JL; Yuan, Q; Zhang, RD | 1 |
| Arruri, VK; Gundu, C; Kalvala, AK; Kumar, A; Kumar, R; Sherkhane, B | 1 |
| Kanda, H; Yamawaki, K | 1 |
| Block, GA; Chertow, GM; Chin, MP; Ferguson, DA; Goldsberry, A; Jadoul, M; Lewis, JH; Meyer, CJ; O'Grady, M; Pergola, PE; Reisman, SA; Wigley, WC | 1 |
| Luo, M; Maimone, TJ; McKenna, JM; Nomura, DK; Schirle, M; Spradlin, JN; Tallarico, JA; Tong, B; Xie, Y | 1 |
| Campagna, R; Chlopicki, S; Grosicki, M; Jamrozik, M; Kaczara, P; Stojak, M; Szczesny-Malysiak, E | 1 |
| Andreoli, S; Appel, GB; Bangalore, S; Block, GA; Chapman, AB; Chertow, GM; Chin, MP; Gibson, KL; Goldsberry, A; Iijima, K; Inker, LA; Knebelmann, B; Mariani, LH; Meyer, CJ; Nozu, K; O'Grady, M; Pergola, PE; Silva, AL; Stenvinkel, P; Torra, R; Warady, BA | 1 |
| Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Fusco, R; Genovese, T; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Siracusa, R | 1 |
| Huang, B; Lai, L; Li, C; Liang, H; Liu, H; Lu, R; Sun, Q; Tan, W; Ye, F; Zhao, L | 1 |
| Gong, Y; Huang, ZJ; Mou, Y; Qiao, X; Wen, XD; Zhang, YH | 1 |
| Guo, Q; Liu, Z; Smith, WW; Wang, B; Wang, X; Zhu, Y | 1 |
| Bock, I; Bouwman, P; Dinnyés, A; Fehér, A; Jennings, P; Kobolák, J; Kumar, M; Le Dévédec, SE; Moné, MJ; Niemeijer, M; Snijders, KE; Táncos, Z; Téglási, A; Ter Braak, B; van de Water, B; van den Berk, L; Van Rossom, R; Verfaillie, CM; Wilmes, A | 1 |
| Cao, L; Guo, C; Jiang, Z; Pang, Z; Song, C; Tang, H; Zhu, R | 1 |
| Ichikawa, T; Imoto, A; Ishii, N; Katagiri, M; Kawakami, F; Kurosaki, Y; Morita, A; Nielsen, R; Ouchi, M; Takenaka, T; Yokoba, M | 1 |
| Deguchi, T; Hashiguchi, H; Kawade, S; Nishio, Y; Ogiso, K; Shayo, SC | 1 |
| Jayasinghe, K; Quinlan, C | 1 |
| Huang, A; Ji, X; Jia, Z; Jiang, W; Tang, H; Wang, Z; Yang, X | 1 |
| Kim, JE; Kim, TH; Lee, DS; Park, H | 1 |
| Gatbonton-Schwager, T; Joshi, T; Kensler, TW; Srinivasan, H; Suzuki, T; Wakabayashi, N; Yagishita, Y; Yamamoto, M | 1 |
| Amirova, KM; Dimitrova, PA; Dinkova-Kostova, AT; Georgiev, MI; Koycheva, IK; Leseva, MN | 1 |
23 review(s) available for oleanolic acid and bardoxolone methyl
| Article | Year |
|---|---|
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.
Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Indolequinones; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triterpenes | 2017 |
Treatment of chronic kidney disease.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Diabetes Mellitus, Type 2; Disease Progression; Endothelin-1; Humans; Hypertension; Kidney Failure, Chronic; Oleanolic Acid; Pyridones; Renal Insufficiency, Chronic; Renin-Angiotensin System | 2012 |
Oleanolic acid.
Topics: Antineoplastic Agents, Phytogenic; Cells, Cultured; Humans; Liver; Oleanolic Acid; Plants; Protective Agents | 2012 |
Prospective safety study of bardoxolone methyl in patients with type 2 diabetes mellitus, end-stage renal disease and peritoneal dialysis.
Topics: Clinical Trials as Topic; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Inflammation; Kidney Failure, Chronic; Oleanolic Acid; Peritoneal Dialysis; Prospective Studies; Research Design; Sample Size | 2012 |
A preliminary evaluation of bardoxolone methyl for the treatment of diabetic nephropathy.
Topics: Administration, Oral; Chronic Disease; Diabetic Nephropathies; Drug Evaluation; Humans; NF-E2-Related Factor 2; Oleanolic Acid; Signal Transduction | 2012 |
Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl.
Topics: Animals; Antioxidants; Chronic Disease; Diabetes Mellitus, Type 2; Humans; Kidney Diseases; Kidney Function Tests; NF-E2-Related Factor 2; Oleanolic Acid; Oxidants | 2012 |
Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease.
Topics: Acute Kidney Injury; Animals; Anti-Infective Agents; Antioxidants; Disease Progression; Humans; Inflammation; Kidney; Kidney Failure, Chronic; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Renal Insufficiency, Chronic; Time Factors; Treatment Outcome | 2013 |
Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases.
Topics: Acute Kidney Injury; Animals; Antioxidants; Chronic Disease; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Renal Insufficiency; Renal Insufficiency, Chronic; Signal Transduction | 2013 |
Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment.
Topics: Animals; Antineoplastic Agents; Humans; Neoplasms; Oleanolic Acid | 2014 |
Have we reached the limits for the treatment of diabetic nephropathy?
Topics: Animals; Diabetic Nephropathies; Humans; Oleanolic Acid; Pyridoxamine; Renin-Angiotensin System; Vitamin D | 2014 |
Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?
Topics: Animals; Diabetes Complications; Humans; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Leupeptins; Mice; Mice, Knockout; Molecular Targeted Therapy; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Resveratrol; Stilbenes; Sulfoxides | 2014 |
Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).
Topics: Amides; Animals; Anti-Inflammatory Agents; Endocannabinoids; Ethanolamines; Humans; Oleanolic Acid; Palmitic Acids; Renal Insufficiency, Chronic | 2014 |
Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.
Topics: Animals; Humans; Hypertension, Pulmonary; Inflammation; Neoplasms; Oleanolic Acid; Renal Insufficiency, Chronic | 2014 |
The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.
Topics: Animals; Anti-Inflammatory Agents; Antioxidant Response Elements; Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; Molecular Targeted Therapy; NF-E2-Related Factor 2; Oleanolic Acid; Signal Transduction | 2016 |
MicroRNA-125b as a new potential biomarker on diagnosis of renal ischemia-reperfusion injury.
Topics: Animals; Antioxidants; Biomarkers; Kidney; MicroRNAs; Oleanolic Acid; Oxidative Stress; Random Allocation; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reperfusion Injury | 2017 |
Developing Treatments for Chronic Kidney Disease in the 21st Century.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Atrasentan; Benzhydryl Compounds; Canagliflozin; Diabetic Nephropathies; Drug Discovery; Endothelin Receptor Antagonists; Glucosides; Glycosaminoglycans; Humans; Hypoglycemic Agents; Mineralocorticoid Receptor Antagonists; Oleanolic Acid; Oxidative Stress; Pyridoxamine; Pyrrolidines; Renal Insufficiency, Chronic; Sodium-Glucose Transporter 2 Inhibitors | 2016 |
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.
Topics: Acute Kidney Injury; Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Glomerular Filtration Rate; Humans; Kelch-Like ECH-Associated Protein 1; Kidney Tubules; Mice; Molecular Targeted Therapy; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Proteasome Endopeptidase Complex; Proteolysis; Reactive Oxygen Species; Renal Insufficiency, Chronic; Signal Transduction; Ubiquitination | 2017 |
[Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2].
Topics: 1-Naphthylamine; Autophagy; Dimethyl Fumarate; Drug Discovery; High-Throughput Screening Assays; Humans; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Microsomes, Liver; NF-E2-Related Factor 2; Oleanolic Acid; Phosphorylation; Protein Interaction Maps; Sequestosome-1 Protein; Sulfonamides; Sulfoxides | 2018 |
Pentacyclic triterpenes: New tools to fight metabolic syndrome.
Topics: Animals; Heart; Humans; Insulin Resistance; Liver; Metabolic Syndrome; Muscle, Skeletal; Oleanolic Acid; Oxidative Stress; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid | 2018 |
Lights and shadows of electrophile signaling: focus on the Nrf2-Keap1 pathway.
Topics: Animals; Antioxidants; Cysteine; Dimethyl Fumarate; Drug Design; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Structure; NF-E2-Related Factor 2; Oleanolic Acid; Oxidation-Reduction; Oxidative Stress; Signal Transduction; Structure-Activity Relationship | 2019 |
[Bardoxolone: a new potential therapeutic agent in the treatment of autosomal dominant polycystic kidney disease?]
Topics: Clinical Trials as Topic; Disease Progression; Down-Regulation; Early Termination of Clinical Trials; Glomerular Filtration Rate; Heart Failure; Humans; Kidney Failure, Chronic; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Polycystic Kidney, Autosomal Dominant; Renal Agents | 2019 |
Synthesis and Anticancer Activity of CDDO and CDDO-Me, Two Derivatives of Natural Triterpenoids.
Topics: Antineoplastic Agents; Metabolic Networks and Pathways; Mitochondria; Molecular Structure; Oleanolic Acid; Triterpenes | 2019 |
Bardoxolone methyl: drug development for diabetic kidney disease.
Topics: Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diabetic Nephropathies; Glomerular Filtration Rate; Humans; Japan; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oleanolic Acid | 2020 |
16 trial(s) available for oleanolic acid and bardoxolone methyl
| Article | Year |
|---|---|
Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD.
Topics: Adult; Aged; Antioxidants; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Inflammation; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Oleanolic Acid; Oxidative Stress; Placebos; Time Factors | 2011 |
Bardoxolone methyl and kidney function in CKD with type 2 diabetes.
Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Oleanolic Acid; Renal Insufficiency, Chronic; Spasm | 2011 |
A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Renal Cell; Colorectal Neoplasms; Cyclin D1; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Janus Kinases; Kidney Neoplasms; Lymphoma; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; NAD(P)H Dehydrogenase (Quinone); Neoplasms; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; RNA, Messenger; STAT Transcription Factors; Thyroid Neoplasms; Young Adult | 2012 |
Rationale and trial design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON).
Topics: Anti-Inflammatory Agents; Clinical Trials Data Monitoring Committees; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Early Termination of Clinical Trials; Glomerular Filtration Rate; Humans; Oleanolic Acid; Renal Insufficiency, Chronic; Treatment Outcome | 2013 |
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial.
Topics: Adolescent; Adult; Aged; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Oleanolic Acid; Prognosis; Renal Insufficiency, Chronic; Young Adult | 2013 |
Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.
Topics: Aged; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Intention to Treat Analysis; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Middle Aged; NF-E2-Related Factor 2; Oleanolic Acid; Renal Insufficiency, Chronic; Treatment Failure; Weight Loss | 2013 |
Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl.
Topics: Animals; Diabetes Mellitus, Type 2; Double-Blind Method; Early Termination of Clinical Trials; Heart Failure; Humans; Macaca fascicularis; Male; Oleanolic Acid; Rats; Renal Insufficiency, Chronic; Sodium; Urine; Water-Electrolyte Imbalance | 2014 |
Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl.
Topics: Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Early Termination of Clinical Trials; Female; Follow-Up Studies; Glomerular Filtration Rate; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Oleanolic Acid; Patient Safety; Predictive Value of Tests; Reference Values; Renal Insufficiency, Chronic; Risk Factors; Severity of Illness Index; Survival Rate; Treatment Outcome | 2014 |
A food effect study and dose proportionality study to assess the pharmacokinetics and safety of bardoxolone methyl in healthy volunteers.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antioxidants; Drug Monitoring; Fasting; Female; Food-Drug Interactions; Healthy Volunteers; Humans; Male; Middle Aged; Models, Biological; Oleanolic Acid; Postprandial Period; Risk Assessment; Wisconsin; Young Adult | 2014 |
Bardoxolone Methyl Improves Kidney Function in Patients with Chronic Kidney Disease Stage 4 and Type 2 Diabetes: Post-Hoc Analyses from Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes Study.
Topics: Aged; Diabetes Mellitus, Type 2; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Heart Failure; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Oleanolic Acid; Renal Dialysis; Treatment Outcome | 2018 |
Effects of bardoxolone methyl on body weight, waist circumference and glycemic control in obese patients with type 2 diabetes mellitus and stage 4 chronic kidney disease.
Topics: Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Male; Middle Aged; Obesity; Oleanolic Acid; Renal Insufficiency, Chronic; Waist Circumference | 2018 |
Effects of Bardoxolone Methyl on QT Interval in Healthy Volunteers.
Topics: Adolescent; Adult; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Female; Healthy Volunteers; Humans; Male; Middle Aged; Moxifloxacin; Oleanolic Acid; Young Adult | 2019 |
Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease.
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Electrocardiography; Female; Glomerular Filtration Rate; Humans; Magnesium; Male; Middle Aged; Oleanolic Acid; Renal Insufficiency, Chronic | 2019 |
Effect of bardoxolone methyl on the urine albumin-to-creatinine ratio in patients with type 2 diabetes and stage 4 chronic kidney disease.
Topics: Adult; Albuminuria; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Early Termination of Clinical Trials; Female; Glomerular Filtration Rate; Heart Failure; Humans; Kidney Failure, Chronic; Male; Middle Aged; Oleanolic Acid; Treatment Outcome | 2019 |
Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD.
Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation, Enzymologic; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Liver; Male; Middle Aged; NF-E2-Related Factor 2; Oleanolic Acid | 2021 |
Study Design and Baseline Characteristics of the CARDINAL Trial: A Phase 3 Study of Bardoxolone Methyl in Patients with Alport Syndrome.
Topics: Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Nephritis, Hereditary; Oleanolic Acid; Research Design; Treatment Outcome | 2021 |
168 other study(ies) available for oleanolic acid and bardoxolone methyl
| Article | Year |
|---|---|
Novel synthetic oleanane triterpenoids: a series of highly active inhibitors of nitric oxide production in mouse macrophages.
Topics: Animals; Interferon-gamma; Macrophages; Mice; Nitric Oxide; Saponins; Structure-Activity Relationship; Triterpenes | 1999 |
Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cells, Cultured; Female; Interferon-gamma; Macrophages, Peritoneal; Mice; Nitric Oxide; Oleanolic Acid; Peritonitis; Structure-Activity Relationship; Thioglycolates; Triterpenes | 2000 |
A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production.
Topics: Animals; Dexamethasone; Interferon-gamma; Macrophages; Mice; Molecular Structure; Nitric Oxide; Nitriles; Oleanolic Acid; Structure-Activity Relationship; Triterpenes | 2002 |
Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Line, Tumor; Cell Survival; Cytoskeletal Proteins; Drug Design; Glutathione S-Transferase pi; Glutathione Transferase; High-Throughput Screening Assays; Humans; Kelch-Like ECH-Associated Protein 1; Liver Neoplasms, Experimental; Mice; Models, Molecular; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Triterpenes | 2016 |
Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study.
Topics: Alkylation; Molecular Structure; NF-kappa B; Oleanolic Acid; Sulfhydryl Compounds | 2017 |
Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors.
Topics: Administration, Oral; Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Female; Humans; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Necroptosis; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Systemic Inflammatory Response Syndrome | 2021 |
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia.
Topics: Annexin A5; Apoptosis; bcl-2-Associated X Protein; Blast Crisis; Caspase 3; Caspases; Cell Differentiation; Cell Survival; Cytarabine; DNA Fragmentation; Drug Interactions; Flow Cytometry; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Membrane Potentials; Mitogen-Activated Protein Kinases; Oleanolic Acid; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Retinoids; Tretinoin; Tumor Cells, Cultured | 2002 |
The anti-inflammatory triterpenoid methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate methanol solvate hydrate.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Oleanolic Acid; Triterpenes | 2002 |
Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspase Inhibitors; Caspases; Cell Differentiation; Cell Division; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Humans; Lung Neoplasms; Mitochondria; Oleanolic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2002 |
Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Survival; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Oleanolic Acid; Protease Inhibitors; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells | 2003 |
c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Non-Small-Cell Lung; Caspase 8; Caspases; Cell Line, Tumor; Drug Synergism; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Membrane Glycoproteins; Oleanolic Acid; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Up-Regulation | 2004 |
The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells.
Topics: Acute Disease; Apoptosis; Humans; Leukemia, Myeloid; MAP Kinase Signaling System; Neoplastic Stem Cells; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Triterpenes; Tumor Cells, Cultured | 2005 |
A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cyclooxygenase 2; Gene Expression; Humans; I-kappa B Kinase; Imidazoles; Leukemia; Matrix Metalloproteinase 9; NF-kappa B; Oleanolic Acid; Phosphorylation; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; TNF Receptor-Associated Death Domain Protein; Triterpenes; Tumor Necrosis Factors; U937 Cells | 2006 |
Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).
Topics: Antioxidants; Apoptosis; Blotting, Northern; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Oleanolic Acid; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2006 |
Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
Topics: Cell Line; Cysteine; Enzyme Inhibitors; Humans; I-kappa B Kinase; Mutation; NF-kappa B; Oleanolic Acid; Oxidation-Reduction; Oxygen; Phosphorylation; Recombinant Proteins; Subcellular Fractions; Tumor Necrosis Factor-alpha; U937 Cells | 2006 |
Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Imidazoles; Mitochondria; Neuroblastoma; NF-kappa B; Oleanolic Acid; Proto-Oncogene Proteins c-akt; Receptor, Notch1; Signal Transduction; Triterpenes | 2007 |
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Humans; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Oleanolic Acid; Phosphorylation; STAT3 Transcription Factor; Urethane | 2007 |
The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.
Topics: Animals; Apoptosis; Cell Growth Processes; Dendritic Cells; Female; Genetic Vectors; Lentivirus; Luciferases, Renilla; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Oleanolic Acid; Signal Transduction; Spleen; STAT3 Transcription Factor | 2007 |
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Topics: Cytokines; Drug Evaluation, Preclinical; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Leukocytes, Mononuclear; Lipopolysaccharides; Neutrophils; NF-E2-Related Factor 2; Oleanolic Acid; Reactive Oxygen Species; Receptors, Formyl Peptide; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells.
Topics: Apoptosis; Caspase 3; Ceramides; Child; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Fenretinide; Humans; Imidazoles; Nitric Oxide; Oleanolic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reactive Oxygen Species; Tumor Cells, Cultured | 2008 |
The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent.
Topics: Angiogenesis Inhibitors; Animals; Cell Division; Cells, Cultured; Collagen; Drug Combinations; Humans; Laminin; Mice; Neoplasms; Oleanolic Acid; Proteoglycans; Sarcoma, Kaposi | 2007 |
PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.
Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Histones; Humans; Leukemia, Promyelocytic, Acute; Mice; Mice, Transgenic; Nicotinic Acids; Oleanolic Acid; PPAR gamma; Promoter Regions, Genetic; Protein Processing, Post-Translational; Receptors, Retinoic Acid; Response Elements; RNA, Small Interfering; Tetrahydronaphthalenes; Tretinoin | 2007 |
c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Down-Regulation; Humans; Lung Neoplasms; MAP Kinase Kinase 4; Oleanolic Acid; Proteasome Endopeptidase Complex; Terpenes; TNF-Related Apoptosis-Inducing Ligand; Ubiquitin | 2007 |
Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3.
Topics: Biotin; Breast Neoplasms; Cell Line, Tumor; Dimerization; Female; Genes, Reporter; HeLa Cells; Humans; Interleukin-6; Janus Kinase 1; Oleanolic Acid; Protein Binding; STAT3 Transcription Factor | 2008 |
The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Division; Cells, Cultured; Cytokines; Dopamine; Drug Evaluation, Preclinical; Gene Expression Profiling; Gene Expression Regulation; Lipopolysaccharides; Macrophages, Peritoneal; Mesencephalon; Mice; Microglia; Neurons; Neuroprotective Agents; Oleanolic Acid; Peptide Fragments; Phagocytosis; Prosencephalon; Rats; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2008 |
Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Benzamides; Dose-Response Relationship, Drug; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitochondria; Oleanolic Acid; Oxidation-Reduction; Oxygen; Piperazines; Pyrimidines; Reactive Oxygen Species | 2008 |
CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells.
Topics: Apoptosis; Blotting, Western; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Interleukin-6; Oleanolic Acid; Ovarian Neoplasms; Phosphorylation; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Tumor Cells, Cultured | 2009 |
Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-kappaB.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cytokines; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Gene Expression Regulation; I-kappa B Proteins; Imidazoles; Immunity, Cellular; Immunosuppressive Agents; Isoantigens; Killer Cells, Lymphokine-Activated; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Oleanolic Acid; Phosphorylation; T-Lymphocytes; T-Lymphocytes, Cytotoxic | 2008 |
Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Movement; Drug Synergism; Endothelial Cells; Female; Humans; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Neovascularization, Pathologic; Nicotinic Acids; Oleanolic Acid; Receptor, ErbB-2; Receptors, Estrogen; Tetrahydronaphthalenes | 2008 |
Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Endoplasmic Reticulum; Enzyme Activation; Glutathione; Humans; Lung Neoplasms; MAP Kinase Kinase 4; Oleanolic Acid; Receptors, TNF-Related Apoptosis-Inducing Ligand; Transcription Factor CHOP; Transcription, Genetic; Up-Regulation | 2008 |
Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR.
Topics: Animals; Apoptosis; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; NF-kappa B; Nuclear Proteins; Oleanolic Acid; Prostatic Neoplasms; Protein Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Triterpenes | 2009 |
Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism.
Topics: Apoptosis; Cell Line, Tumor; Growth Inhibitors; Humans; Male; Oleanolic Acid; Prostatic Neoplasms; Reactive Oxygen Species | 2010 |
Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.
Topics: Adenocarcinoma; Animals; Cell Proliferation; Fatty Acids, Unsaturated; Female; Ligands; Lung Neoplasms; Macrophages; Mice; Mice, Inbred A; Nicotinic Acids; Oleanolic Acid; Rats; Tetrahydronaphthalenes; Urethane | 2009 |
Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis.
Topics: Adolescent; Apoptosis; Biomarkers, Tumor; Bone Neoplasms; Cell Division; Cell Line, Tumor; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Immunohistochemistry; Male; Middle Aged; Oleanolic Acid; Osteosarcoma; Phosphorylation; Prognosis; Signal Transduction; STAT3 Transcription Factor; Young Adult | 2010 |
Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.
Topics: Aged; Aged, 80 and over; Animals; Arginase; Clinical Trials, Phase I as Topic; Dendritic Cells; Female; Humans; Immune Tolerance; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Mice, SCID; Middle Aged; Myeloid Cells; Neoplasms, Experimental; Nitric Oxide; Oleanolic Acid; Prognosis; Reactive Oxygen Species | 2010 |
The triterpenoid CDDO-Me delays murine acute graft-versus-host disease with the preservation of graft-versus-tumor effects after allogeneic bone marrow transplantation.
Topics: Animals; Apoptosis; Bone Marrow Transplantation; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colon; Female; Graft vs Host Disease; Graft vs Tumor Effect; Immunosuppressive Agents; Integrins; Leukemia, Myeloid, Acute; Liver; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oleanolic Acid; Spleen; Survival Analysis; T-Lymphocytes; Transplantation, Homologous; Tumor Necrosis Factor-alpha | 2010 |
Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma.
Topics: Antineoplastic Agents, Phytogenic; Chordoma; Growth Inhibitors; Humans; Oleanolic Acid; Organ Culture Techniques; Spinal Neoplasms; STAT3 Transcription Factor | 2010 |
Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells.
Topics: Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Caspases; Colorectal Neoplasms; Enzyme Activation; HCT116 Cells; HT29 Cells; Humans; Imidazoles; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; NF-kappa B; Oleanolic Acid; Oncogene Protein v-akt; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Survivin; TOR Serine-Threonine Kinases; Triterpenes | 2010 |
Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; bcl-X Protein; Bone Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Oleanolic Acid; Osteosarcoma; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; STAT3 Transcription Factor; Survivin; Time Factors | 2010 |
Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.
Topics: Animals; Base Sequence; Blotting, Western; Cell Line, Tumor; Cell Proliferation; DNA Primers; Humans; Male; Mice; Mice, Nude; MicroRNAs; Oleanolic Acid; Pancreatic Neoplasms; Polymerase Chain Reaction; Reactive Oxygen Species; Transcription Factors | 2010 |
Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Enzyme Inhibitors; Humans; Neoplasm Invasiveness; NF-kappa B; Nitriles; Oleanolic Acid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfones; Thyroid Neoplasms | 2010 |
Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.
Topics: Actin-Related Protein 2-3 Complex; Actins; Animals; Biological Transport; Cell Movement; Cell Polarity; Humans; Imidazoles; Models, Molecular; Oleanolic Acid; Protein Multimerization; Protein Structure, Quaternary; Rats; Triterpenes | 2010 |
Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation.
Topics: Aged; Aged, 80 and over; Animals; Apoptosis; Caspase 3; Cell Growth Processes; Cell Survival; Drug Synergism; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mutation; Oleanolic Acid; Phosphorylation; Signal Transduction; Staurosporine | 2010 |
The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.
Topics: Animals; Cells, Cultured; Dendritic Cells; Female; Heme Oxygenase (Decyclizing); Immunomodulation; Inflammation; Inflammation Mediators; Interleukin-17; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Oleanolic Acid; Spleen; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2010 |
CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells.
Topics: Base Sequence; Blotting, Western; Cell Transformation, Neoplastic; Chromosome Aberrations; Colon; Cosmic Radiation; DNA Primers; Humans; Immunohistochemistry; Intestinal Mucosa; Karyotyping; Oleanolic Acid; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.
Topics: Acetyl-CoA Carboxylase; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diet; Enzyme Activation; Fatty Acids, Nonesterified; Glucose; Hypoglycemic Agents; Insulin; Mice; Mice, Mutant Strains; Muscle, Skeletal; Oleanolic Acid; Phosphorylation; Protein Serine-Threonine Kinases; Triglycerides | 2010 |
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; Mice; Mice, Transgenic; Nicotinic Acids; Oleanolic Acid; Pancreatic Neoplasms; Signal Transduction; Tetrahydronaphthalenes | 2010 |
Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Capillaries; Cisplatin; Disease Models, Animal; Fluorescent Antibody Technique; Heme Oxygenase-1; Ischemia; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; PPAR gamma; RNA, Messenger; Time Factors; Up-Regulation | 2011 |
Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury.
Topics: Animals; Antioxidants; Capillaries; Cytoprotection; Gene Expression; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Nerve Degeneration; NF-E2-Related Factor 2; Oleanolic Acid; Reactive Oxygen Species; Reperfusion Injury; Retinal Vessels | 2011 |
Role of reactive oxygen species (ROS) in CDDO-Me-mediated growth inhibition and apoptosis in colorectal cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Free Radicals; Humans; Oleanolic Acid; Reactive Oxygen Species | 2011 |
Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway.
Topics: Blotting, Western; Cell Line; Cell Survival; Chemical Warfare Agents; Drug Interactions; Epidermal Cells; Epidermis; Glutathione; Humans; Inactivation, Metabolic; Keratinocytes; Mustard Gas; NF-E2-Related Factor 2; Oleanolic Acid | 2011 |
Diabetes: bardoxolone improves kidney function in type 2 diabetes.
Topics: Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Humans; Inactivation, Metabolic; Kidney Failure, Chronic; NF-E2-Related Factor 2; Oleanolic Acid | 2011 |
Bardoxolone: augmenting the Yin in chronic kidney disease.
Topics: Chronic Disease; Clinical Trials, Phase II as Topic; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; NF-E2-Related Factor 2; Oleanolic Acid; Randomized Controlled Trials as Topic; Signal Transduction; Time Factors; Treatment Outcome; Yin-Yang | 2011 |
CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.
Topics: Animals; Anticarcinogenic Agents; BRCA1 Protein; Cell Cycle; Female; Genes, BRCA1; Genes, p53; Mammary Neoplasms, Animal; Mice; Mutation; Oleanolic Acid; Phosphorylation; Receptor, ErbB-2 | 2012 |
Bardoxolone methyl: a targeted antioxidant.
Topics: Animals; Antioxidants; Chronic Disease; Humans; Kidney Diseases; Oleanolic Acid | 2011 |
The triterpenoid CDDO-Me promotes hematopoietic progenitor expansion and myelopoiesis in mice.
Topics: Animals; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Myelopoiesis; Oleanolic Acid | 2012 |
Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-κB/mTOR signaling.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; NF-kappa B; Oleanolic Acid; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2011 |
Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Male; NF-kappa B; Oleanolic Acid; Prostatic Neoplasms; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; TOR Serine-Threonine Kinases | 2012 |
Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.
Topics: Actins; Biomarkers; Blotting, Western; Cell Transdifferentiation; Cells, Cultured; Collagen Type I; Cornea; Fibroblasts; Fibronectins; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Humans; Ligands; Myofibroblasts; Oleanolic Acid; PPAR gamma; Prostaglandin D2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | 2012 |
Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress.
Topics: Antioxidants; Drug Industry; Humans; Inflammation; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress | 2012 |
[Chronic kidney disease, new therapeutic approaches].
Topics: Angiotensin-Converting Enzyme Inhibitors; Disease Progression; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Oleanolic Acid; Prognosis; Protein Kinase Inhibitors; Renal Insufficiency, Chronic; Treatment Outcome | 2012 |
New hope or drawbacks: will chronic kidney disease be treatable with small molecules in the near future?
Topics: Anti-Inflammatory Agents; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Kidney; NF-E2-Related Factor 2; Oleanolic Acid; Renal Insufficiency, Chronic | 2012 |
The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.
Topics: Animals; Anticarcinogenic Agents; Antigens, Polyomavirus Transforming; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Drug Evaluation, Preclinical; Female; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Oleanolic Acid; Receptors, Estrogen; Time Factors; Triterpenes | 2012 |
Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.
Topics: Alkynes; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cytoprotection; I-kappa B Kinase; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice; NAD(P)H Dehydrogenase (Quinone); Nitric Oxide; Nitriles; Oleanolic Acid; Phenanthrenes; Thiophenes; Tumor Necrosis Factor-alpha | 2012 |
Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Oleanolic Acid; Pancreatic Neoplasms; Suppression, Genetic; Telomerase | 2012 |
Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.
Topics: Albuminuria; Animals; Antioxidants; Creatinine; Female; Glutathione Reductase; Kidney; Low Density Lipoprotein Receptor-Related Protein-2; Macaca fascicularis; Male; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oleanolic Acid; Receptors, Cell Surface; RNA, Messenger; Up-Regulation | 2012 |
Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Oleanolic Acid; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides | 2012 |
New treatments for CKD--new insights into pathogenesis.
Topics: Animals; Female; Kidney; Low Density Lipoprotein Receptor-Related Protein-2; Male; NF-E2-Related Factor 2; Oleanolic Acid | 2012 |
Identification of unique sensitizing targets for anti-inflammatory CDDO-Me in metastatic melanoma by a large-scale synthetic lethal RNAi screening.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, Neoplasm; High-Throughput Screening Assays; Humans; Melanoma; Neoplasm Metastasis; Oleanolic Acid; Reproducibility of Results; RNA Interference; RNA, Small Interfering; Signal Transduction; Skin Neoplasms; Treatment Outcome | 2013 |
[Diabetes and the kidneys].
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Clinical Trials as Topic; Diabetic Nephropathies; Drug Therapy, Combination; Evidence-Based Medicine; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Islets of Langerhans Transplantation; Oleanolic Acid; Pancreas Transplantation | 2012 |
Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Chromatography, Liquid; Diabetic Nephropathies; Disease Models, Animal; Diuresis; Drinking; Hemodynamics; Kidney; Liver; Male; Mass Spectrometry; Oleanolic Acid; Ramipril; Rats; Rats, Zucker; Renal Circulation; Triterpenes | 2013 |
Bardoxolone brings Nrf2-based therapies to light.
Topics: Clinical Trials, Phase III as Topic; Humans; NF-E2-Related Factor 2; Oleanolic Acid; Renal Insufficiency, Chronic | 2013 |
ROS mediate proapoptotic and antisurvival activity of oleanane triterpenoid CDDO-Me in ovarian cancer cells.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hydrogen Peroxide; Oleanolic Acid; Ovarian Neoplasms; Reactive Oxygen Species; Signal Transduction | 2013 |
Diabetic nephropathy: Could problems with bardoxolone methyl have been predicted?
Topics: Animals; Clinical Trials, Phase III as Topic; Diabetic Nephropathies; Disease Models, Animal; Early Termination of Clinical Trials; Glomerular Filtration Rate; Humans; Oleanolic Acid | 2013 |
The extinguished BEACON of bardoxolone: not a Monday morning quarterback story.
Topics: Anti-Inflammatory Agents; Diabetic Nephropathies; Early Termination of Clinical Trials; Humans; Oleanolic Acid; Proteinuria; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Spasm; Weight Loss | 2013 |
Inhibition of telomerase activity by oleanane triterpenoid CDDO-Me in pancreatic cancer cells is ROS-dependent.
Topics: Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Oleanolic Acid; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Telomerase | 2013 |
Telomerase reverse transcriptase (TERT) is a therapeutic target of oleanane triterpenoid CDDO-Me in prostate cancer.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation; Humans; Male; Mice; NF-kappa B; Oleanolic Acid; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; STAT3 Transcription Factor; Telomerase | 2012 |
Efficient and scalable synthesis of bardoxolone methyl (cddo-methyl ester).
Topics: Anti-Inflammatory Agents; Chromatography; Diabetes Mellitus, Type 2; Esters; Humans; Molecular Structure; Oleanolic Acid; Renal Insufficiency, Chronic | 2013 |
Detecting and controlling diabetic nephropathy: what do we know?
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Humans; Hypoglycemic Agents; Oleanolic Acid; Renin-Angiotensin System | 2013 |
Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.
Topics: Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Eating; Glucose; Kidney; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oleanolic Acid; Rats; Rats, Zucker | 2013 |
The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.
Topics: Actins; Administration, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Fibronectins; Gene Expression; Humans; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Oleanolic Acid; Pneumonia; Pulmonary Fibrosis; Respiratory Function Tests; Transforming Growth Factor beta | 2013 |
New therapies for diabetic kidney disease.
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic | 2013 |
Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO).
Topics: Amino Acids; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Mice; Nitric Oxide; Oleanolic Acid | 2014 |
Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Cryoprotective Agents; Disease Models, Animal; Heme Oxygenase-1; Kidney; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oleanolic Acid | 2014 |
Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury.
Topics: Animals; Astrocytes; Blotting, Western; Brain Ischemia; Disease Models, Animal; Humans; Immunohistochemistry; Immunoprecipitation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reperfusion Injury | 2014 |
Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Enzyme Induction; Hydroxyprostaglandin Dehydrogenases; Intestinal Mucosa; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Oleanolic Acid; Smad4 Protein; STAT Transcription Factors | 2014 |
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cytoskeletal Proteins; Female; Gene Expression Regulation, Enzymologic; Humans; Kelch-Like ECH-Associated Protein 1; Liver; Male; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oleanolic Acid; Oxidoreductases; Proteome; Proto-Oncogene Proteins c-akt; Signal Transduction | 2014 |
Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid.
Topics: Animals; Apoptosis; Autoantibodies; Blood Urea Nitrogen; CD4-Positive T-Lymphocytes; Disease Models, Animal; Female; Lupus Nephritis; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Mutant Strains; NF-kappa B; Oleanolic Acid; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor | 2014 |
Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA).
Topics: Animals; Antimetabolites; Female; Gene Expression; Immune Tolerance; Immunosuppressive Agents; Local Lymph Node Assay; Lymph Nodes; Mice, Inbred BALB C; Oleanolic Acid; Organ Size; Oxygenases | 2014 |
The effect of ex vivo CDDO-Me activation on nuclear factor erythroid 2-related factor 2 pathway in white blood cells from patients with septic shock.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Cells, Cultured; Female; Gene Expression Regulation; Humans; Interleukin-6; Leukocytes, Mononuclear; Male; Middle Aged; NF-E2-Related Factor 2; Oleanolic Acid; Reactive Oxygen Species; RNA, Messenger; Shock, Septic; Signal Transduction; Young Adult | 2014 |
The endothelin pathway: a protective or detrimental target of bardoxolone methyl on cardiac function in patients with advanced chronic kidney disease?
Topics: Blood Pressure; Cardiovascular System; Clinical Trials, Phase III as Topic; Early Termination of Clinical Trials; Endothelins; Heart; Heart Failure; Humans; Kidney; Kidney Failure, Chronic; Oleanolic Acid | 2014 |
CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation.
Topics: Animals; Antioxidants; Breast; Breast Neoplasms; Cell Line; Cell Line, Tumor; DNA Damage; Epithelial Cells; Female; Humans; Lung; Lung Neoplasms; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Radiation-Protective Agents; Signal Transduction | 2014 |
Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory.
Topics: Animals; Autoradiography; Diet, High-Fat; Disease Models, Animal; Dizocilpine Maleate; Drug Administration Schedule; Exploratory Behavior; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oleanolic Acid; Prefrontal Cortex; Protein Binding; Recognition, Psychology; Signal Transduction; Statistics, Nonparametric; Tritium | 2015 |
The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Cell Line; Cell Movement; Cytokines; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; Neutrophils; Nitric Oxide Synthase Type II; Oleanolic Acid; Peroxidase | 2015 |
Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet.
Topics: Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Diet, High-Fat; Inflammation; Intra-Abdominal Fat; Macrophages; Male; Mice; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Oxidative Stress; Tumor Necrosis Factor-alpha | 2015 |
Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells.
Topics: Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Neoplastic Stem Cells; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 2015 |
Cytoprotection of human endothelial cells from oxidant stress with CDDO derivatives: network analysis of genes responsible for cytoprotection.
Topics: Cell Survival; Cells, Cultured; Cytoprotection; Gene Expression Profiling; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Oleanolic Acid; Oxidative Stress; Vitamin K 3 | 2015 |
Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Dimethyl Fumarate; Female; Fumarates; Gene Expression Regulation, Neoplastic; Imidazoles; Lung Neoplasms; Mice, Inbred Strains; Mice, Knockout; Molecular Targeted Therapy; Neoplasms, Experimental; NF-E2-Related Factor 2; Oleanolic Acid; Oligonucleotide Array Sequence Analysis; Oxidative Stress | 2015 |
Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet.
Topics: Animals; Cell Movement; Diet, High-Fat; Fatty Liver; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Macrophages; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid | 2015 |
Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me-induced apoptosis in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Calcium; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Cytosol; Down-Regulation; Endoplasmic Reticulum; Female; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Electron, Transmission; Mitochondria; Oleanolic Acid; Reactive Oxygen Species; Superoxides | 2015 |
Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet.
Topics: Adipose Tissue, Brown; Animals; Anti-Inflammatory Agents; Brain Stem; Diet, Fat-Restricted; Diet, High-Fat; Energy Metabolism; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; PPAR gamma; Receptors, Adrenergic, beta-3; Transcription Factors; Tyrosine 3-Monooxygenase | 2015 |
Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Collagen; Cytokines; Cytoprotection; Disease Models, Animal; Female; Gene Expression Regulation; Hydroxyproline; Inflammation Mediators; Lung; Lung Injury; Mice, Inbred C57BL; Oleanolic Acid; Pulmonary Fibrosis; Radiation Pneumonitis; RNA, Messenger | 2015 |
Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells.
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dithiothreitol; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-2; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; MAP Kinase Signaling System; Molecular Structure; Molecular Targeted Therapy; Neoplasm Proteins; Oleanolic Acid; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; RNA Interference; RNA, Small Interfering; Structure-Activity Relationship; Transfection; Up-Regulation | 2015 |
Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cancer Vaccines; Cell Line, Tumor; Drug Synergism; Female; Melanoma; Membrane Proteins; Mice; Mice, Inbred C57BL; Nanocapsules; Oleanolic Acid; Particle Size; Peptide Fragments; Treatment Outcome; Tumor Microenvironment | 2015 |
Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.
Topics: Aconitate Hydratase; Antineoplastic Agents; Apoptosis; ATP-Dependent Proteases; Cell Death; Cell Proliferation; DNA-Binding Proteins; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hydrogen Peroxide; MCF-7 Cells; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Neoplasms; Oleanolic Acid; Oxidative Stress; Protease Inhibitors; Protein Carbonylation; Signal Transduction; Superoxides; Time Factors; Transcription Factors; Transfection | 2015 |
CDDO-Me inhibits tumor growth and prevents recurrence of pancreatic ductal adenocarcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice; Mice, SCID; Neoplasm Recurrence, Local; Oleanolic Acid; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2015 |
Effects of captopril, telmisartan and bardoxolone methyl (CDDO-Me) in ischemia-reperfusion-induced acute kidney injury in rats: an experimental comparative study.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Antioxidants; Apoptosis; Arginine; Benzimidazoles; Benzoates; Captopril; Creatine; Endothelin-1; Gene Expression Regulation; Glutathione Peroxidase; Ischemia; Kidney; Lipocalin-2; Lipocalins; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oleanolic Acid; Proto-Oncogene Proteins; Rats; Rats, Wistar; Reperfusion Injury; Sulfhydryl Compounds; Superoxide Dismutase; Telmisartan; Urea | 2016 |
Bardoxolone methyl prevents the development and progression of cardiac and renal pathophysiologies in mice fed a high-fat diet.
Topics: Animals; Anti-Inflammatory Agents; Cardiomegaly; Diet, High-Fat; Fats; Heart; Hypertrophy; Inflammation; Kidney; Male; Mice, Inbred C57BL; Myocardium; Oleanolic Acid | 2016 |
Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice.
Topics: AMP-Activated Protein Kinases; Animals; Cytokines; Diet, High-Fat; Energy Metabolism; Extracellular Signal-Regulated MAP Kinases; Inflammation; Intra-Abdominal Fat; Ion Channels; Macrophages; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Oleanolic Acid; Oxidative Stress; PPAR gamma; Proto-Oncogene Proteins c-akt; Uncoupling Protein 2 | 2015 |
Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation.
Topics: Animals; Anticoagulants; Antigens, CD; Behavior, Animal; Blood-Brain Barrier; Brain Ischemia; Cadherins; Endothelial Cells; Intracranial Hemorrhages; Male; Mice; Neurons; NF-E2-Related Factor 2; Oleanolic Acid; Pericytes; Reperfusion Injury; Survival Analysis; Tight Junction Proteins; Warfarin | 2016 |
CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Cytokines; Female; Gene Expression Regulation, Neoplastic; Humans; Macrophage Activation; Macrophages; Mice; Oleanolic Acid; RNA, Messenger; T-Lymphocytes | 2016 |
Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.
Topics: Animals; Anti-Inflammatory Agents; Colon; Cytokines; Diet, High-Fat; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid | 2016 |
Bardoxolone methyl prevents obesity and hypothalamic dysfunction.
Topics: Animals; Anti-Obesity Agents; Body Weight; Diet, High-Fat; Energy Intake; Energy Metabolism; Hypothalamus; Inflammation; Leptin; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Signal Transduction | 2016 |
Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.
Topics: Antineoplastic Agents; Cell Survival; Cells, Cultured; Cisplatin; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression Regulation; Humans; Kidney Tubules, Proximal; NF-E2-Related Factor 2; Oleanolic Acid; RNA, Messenger | 2016 |
CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Molecular Docking Simulation; Oleanolic Acid; Ovarian Neoplasms; Ubiquitin-Specific Peptidase 7; Up-Regulation; Xenograft Model Antitumor Assays | 2016 |
Protonated montmorillonite-mediated highly specific isomerization of oleanolic acid esters: application to the synthesis of Δ
Topics: Bentonite; Chemistry Techniques, Synthetic; Esters; Isomerism; Oleanolic Acid; Protons | 2016 |
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Gene Expression Profiling; Glycogen Synthase Kinase 3; Humans; Kelch-Like ECH-Associated Protein 1; Lithium Chloride; Longevity; Mice; Microscopy, Confocal; Neurons; NF-E2-Related Factor 2; Oleanolic Acid; Peptide Fragments; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Thiadiazoles; Triazoles | 2017 |
Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium.
Topics: Adenosine Triphosphate; Allergens; Animals; Antioxidants; Calcium; Epithelial Cells; Female; Humans; Interleukin-33; Lung; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Respiratory Mucosa | 2017 |
Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells.
Topics: Antineoplastic Agents; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Glutathione; Humans; I-kappa B Kinase; Leukemia; Oleanolic Acid; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species; Sp Transcription Factors; TOR Serine-Threonine Kinases; Triterpenes | 2017 |
Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells.
Topics: Antioxidants; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Glutathione; Humans; MCF-7 Cells; Mitochondria; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2017 |
The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cells, Cultured; Disease Models, Animal; Fibronectins; Glutaredoxins; Heart; Humans; Male; Myocardial Infarction; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; Oleanolic Acid; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Ventricular Remodeling | 2017 |
Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury.
Topics: Aldosterone; Angiotensinogen; Animals; Blood Pressure; Disease Models, Animal; Fatty Acid-Binding Proteins; Hypertension, Renal; Kidney; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Renin-Angiotensin System; Sodium Chloride; Up-Regulation | 2018 |
Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic Nephropathy.
Topics: Animals; Diabetic Nephropathies; Drug Therapy; gamma-Glutamyltransferase; HEK293 Cells; Humans; Kidney; Mice; Oleanolic Acid; Rats | 2017 |
Bardoxolone-the Phoenix?
Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Diabetic Nephropathies; Disease Progression; Glomerular Filtration Rate; Heart Failure; Humans; Nephritis, Hereditary; Oleanolic Acid; Renal Insufficiency, Chronic | 2018 |
Should We Increase GFR with Bardoxolone in Alport Syndrome?
Topics: Albuminuria; Anti-Inflammatory Agents; Clinical Trials as Topic; Diabetic Nephropathies; Disease Progression; Glomerular Filtration Rate; Heart Failure; Humans; Nephritis, Hereditary; Oleanolic Acid; Renal Insufficiency, Chronic | 2018 |
Identification of a Novel Hybridization from Isosorbide 5-Mononitrate and Bardoxolone Methyl with Dual Activities of Pulmonary Vasodilation and Vascular Remodeling Inhibition on Pulmonary Arterial Hypertension Rats.
Topics: Animals; Cardiomegaly; Drug Design; Fibrosis; Hypertension, Pulmonary; Isosorbide Dinitrate; Nitric Oxide Donors; Oleanolic Acid; Rats; Vascular Remodeling; Vasodilation | 2018 |
Bardoxolone methyl induces neuritogenesis in Neuro2a cells.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression; Mice; Neurites; Neurofilament Proteins; Neuronal Outgrowth; Oleanolic Acid; Signal Transduction; Synaptophysin; Tretinoin; Tubulin; Tyrosine 3-Monooxygenase | 2018 |
Bardoxolone Methyl Suppresses Hepatitis B Virus Large Surface Protein Variant W4P-Related Carcinogenesis and Hepatocellular Carcinoma Cell Proliferation Via the Inhibition of Signal Transducer and Activator of Transcription 3 Signaling.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Genetic Variation; Humans; Mice; Oleanolic Acid; Signal Transduction; STAT3 Transcription Factor; Stem Cells; Tumor Suppressor Protein p53; Viral Envelope Proteins | 2018 |
Mesenchymal stem cells are attracted to latent HIV-1-infected cells and enable virus reactivation via a non-canonical PI3K-NFκB signaling pathway.
Topics: Anti-HIV Agents; Cell Line; Culture Media, Conditioned; Drug Evaluation, Preclinical; Gene Expression Regulation, Viral; Gonanes; HIV Infections; HIV Long Terminal Repeat; HIV-1; Humans; Mesenchymal Stem Cells; NF-kappa B; Oleanolic Acid; Panobinostat; Phosphatidylinositol 3-Kinases; Signal Transduction; Virus Activation; Virus Latency; Vorinostat | 2018 |
RA-839, a selective agonist of Nrf2/ARE pathway, exerts potent anti-rotaviral efficacy in vitro.
Topics: Animals; Antiviral Agents; Cell Line; Hemin; Humans; NF-E2-Related Factor 2; Oleanolic Acid; Rotavirus; Signal Transduction; Vesicular Transport Proteins | 2019 |
Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway.
Topics: Antibiotics, Antineoplastic; Cardiotoxicity; Cell Survival; Dexrazoxane; Doxorubicin; Drug Synergism; Heart; Humans; In Vitro Techniques; Isothiocyanates; NF-E2-Related Factor 2; Oleanolic Acid; Reactive Oxygen Species; Spheroids, Cellular; Sulfoxides | 2019 |
CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response.
Topics: Animals; Antioxidants; Cell Differentiation; Cell Line; Cells, Cultured; Hydroquinones; Isothiocyanates; Male; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; Osteoclasts; Osteogenesis; RANK Ligand; Reactive Oxygen Species; Sulfoxides | 2019 |
Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability.
Topics: Animals; Cell Membrane Permeability; Cell Movement; Cell Proliferation; Cells, Cultured; Choroidal Neovascularization; Disease Models, Animal; Endothelial Cells; Fluorescein Angiography; Fundus Oculi; Humans; Immunoblotting; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; Retinal Neovascularization; Retinal Vessels; Tomography, Optical Coherence; Triterpenes | 2019 |
Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation.
Topics: Animals; Aristolochic Acids; Cell Line; Extracellular Matrix; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; HEK293 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Kidney Diseases; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; RNA, Small Interfering; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta1; Ubiquitin-Protein Ligases | 2019 |
Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems.
Topics: Antiviral Agents; Cell Line; Cell Proliferation; Coinfection; DNA, Viral; Heme Oxygenase-1; Hep G2 Cells; Hepacivirus; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C; Hepatocytes; Humans; NF-E2-Related Factor 2; Oleanolic Acid; Virus Replication | 2019 |
Bardoxolone treatment alleviates lipopolysaccharide (LPS)-induced acute lung injury through suppressing inflammation and oxidative stress regulated by Nrf2 signaling.
Topics: Acute Lung Injury; Animals; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; RAW 264.7 Cells; Signal Transduction | 2019 |
New Approach to Slowing the Progression of Chronic Kidney Disease.
Topics: Disease Progression; Healthy Volunteers; Humans; Oleanolic Acid; Renal Insufficiency, Chronic | 2019 |
CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1.
Topics: Animals; ATP-Dependent Proteases; CA1 Region, Hippocampal; Cell Death; Male; Mitochondrial Dynamics; Neurons; Neuroprotective Agents; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2019 |
Small molecule grp94 inhibitors block dengue and Zika virus replication.
Topics: Antiviral Agents; Cell Survival; Dengue; Dengue Virus; Humans; Membrane Glycoproteins; Oleanolic Acid; Virus Replication; Zika Virus; Zika Virus Infection | 2019 |
Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Biomarkers; Crush Injuries; Male; Oleanolic Acid; Rats; Rats, Wistar | 2021 |
Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer.
Topics: Acetaminophen; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Synergism; Ferroptosis; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; Lipid Peroxides; Malondialdehyde; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Piperazines; Signal Transduction; Xenograft Model Antitumor Assays | 2020 |
Increased albuminuria in bardoxolone methyl-treated type 2 diabetes patients: mere reflection of eGFR improvement?
Topics: Albumins; Albuminuria; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Glomerular Filtration Rate; Humans; Oleanolic Acid; Renal Insufficiency, Chronic; Retrospective Studies | 2019 |
CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus.
Topics: Astrocytes; Brain Edema; Cell Line, Tumor; Gene Expression; Humans; Microglia; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; Oleanolic Acid; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Status Epilepticus; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2019 |
Therapeutic Effects of Nrf2 Activation by Bardoxolone Methyl in Chronic Heart Failure.
Topics: Animals; Chronic Disease; CREB-Binding Protein; Heart Failure; Hemodynamics; Male; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2019 |
In Vitro Biotransformation of the Nrf2 Activator Bardoxolone: Formation of an Epoxide Metabolite That Undergoes Two Novel Glutathione-Mediated Metabolic Pathways: Epoxide Reduction and Oxidative Elimination of Nitrile Moiety.
Topics: Biotransformation; Cytosol; Epoxy Compounds; Glutathione; Hepatocytes; Humans; Microsomes, Liver; NF-E2-Related Factor 2; Nitriles; Oleanolic Acid; Oxidation-Reduction | 2019 |
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Topics: Fibroblasts; Gene Expression Profiling; Gene Regulatory Networks; Herpes Simplex; Herpesvirus 1, Human; Host-Pathogen Interactions; Humans; Isothiocyanates; NF-E2-Related Factor 2; Oleanolic Acid; Primary Cell Culture; Sequence Analysis, RNA; Single-Cell Analysis; Sulfoxides; Virus Replication | 2019 |
Location, Orientation and Aggregation of Bardoxolone-ME, CDDO-ME, in a Complex Phospholipid Bilayer Membrane.
Topics: Hydrocarbons; Lipid Bilayers; Models, Molecular; Molecular Structure; Oleanolic Acid; Phospholipids | 2020 |
The synthetic oleanane triterpenoid CDDO-Me binds and inhibits pyruvate kinase M2.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Glucose; Humans; Hypoxia; Oleanolic Acid; Pyruvate Kinase | 2020 |
CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer.
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cytokines; Female; Gene Expression Regulation, Neoplastic; Macrophages; Mammary Neoplasms, Animal; Mice, Inbred C57BL; Oleanolic Acid; Receptors, Estrogen; Spleen; T-Lymphocytes, Regulatory; Transcriptional Activation; Tumor Microenvironment | 2020 |
CDDO-Me Inhibits Microglial Activation and Monocyte Infiltration by Abrogating NFκB- and p38 MAPK-Mediated Signaling Pathways Following Status Epilepticus.
Topics: Animals; Chemokine CCL2; Frontal Lobe; Male; MAP Kinase Signaling System; Microglia; Models, Biological; Monocytes; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Parietal Lobe; Peptides; Phosphorylation; Phosphoserine; Rats, Sprague-Dawley; Status Epilepticus; Tumor Necrosis Factor-alpha | 2020 |
Triterpenoid CDDO-Me induces ROS generation and up-regulates cellular levels of antioxidative enzymes without induction of DSBs in human peripheral blood mononuclear cells.
Topics: Adult; Apoptosis; Cell Survival; Cells, Cultured; DNA Breaks, Double-Stranded; Female; Humans; Leukocytes, Mononuclear; Male; Micronucleus Tests; Middle Aged; Oleanolic Acid; Reactive Oxygen Species; X-Rays | 2020 |
Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells.
Topics: Apoptosis; Blood Glucose; Diabetic Angiopathies; Drug Evaluation, Preclinical; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2020 |
Bardoxolone Methyl Ameliorates Hyperglycemia Induced Mitochondrial Dysfunction by Activating the keap1-Nrf2-ARE Pathway in Experimental Diabetic Neuropathy.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperglycemia; Hypoglycemic Agents; Kelch-Like ECH-Associated Protein 1; Male; Mitochondria; Oleanolic Acid; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Bardoxolone conjugation enables targeted protein degradation of BRD4.
Topics: Azepines; Cell Cycle Proteins; Cell Line, Tumor; Drug Discovery; Humans; Oleanolic Acid; Proteasome Endopeptidase Complex; Proteolysis; Transcription Factors; Triazoles; Ubiquitin-Protein Ligases; Ubiquitination | 2020 |
Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium.
Topics: Cell Line; Cell Survival; Dimethyl Fumarate; Down-Regulation; Endothelial Cells; Endothelin-1; Gene Expression; Humans; Isothiocyanates; Membrane Potential, Mitochondrial; Microvessels; Mitochondria; NF-E2-Related Factor 2; Oleanolic Acid; Permeability; Reactive Oxygen Species; Sulfoxides | 2020 |
The Methyl Ester of 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid Reduces Endometrial Lesions Development by Modulating the NFkB and Nrf2 Pathways.
Topics: Animals; Apoptosis; Cellular Microenvironment; Cyclooxygenase 2; Cytokines; Endometriosis; Female; Fibrosis; Inflammation; Neovascularization, Physiologic; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidation-Reduction; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction | 2021 |
Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease.
Topics: Antiviral Agents; Computational Chemistry; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Humans; NF-E2-Related Factor 2; Oleanolic Acid; Protease Inhibitors; SARS-CoV-2; Virus Replication | 2021 |
Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice.
Topics: Animals; Colitis; Mesalamine; Mice; Nitroreductases; Oleanolic Acid; Prodrugs | 2021 |
Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
Topics: Adenine; Animals; Animals, Genetically Modified; Antioxidants; Antiparkinson Agents; Astrocytes; Autophagy; Behavior, Animal; Dihydroxyphenylalanine; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Male; Motor Activity; Nerve Degeneration; NF-E2-Related Factor 2; Oleanolic Acid; Parkinsonian Disorders; Phenotype; Rats, Sprague-Dawley; Repressor Proteins; Rotenone; Signal Transduction; Sirolimus | 2021 |
Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages.
Topics: Cell Differentiation; Cells, Cultured; CRISPR-Cas Systems; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Heme Oxygenase-1; Humans; Induced Pluripotent Stem Cells; Male; Maleates; Middle Aged; Oleanolic Acid; Oxidative Stress; RNA, Messenger; Time Factors | 2021 |
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Topics: Animals; Apoptosis; Arthritis, Experimental; Cartilage; Cell Survival; Chondrocytes; Dose-Response Relationship, Drug; Extracellular Matrix; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Osteoarthritis; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2021 |
In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells.
Topics: Cell Line; Cellular Senescence; Cisplatin; Humans; Kidney Tubules, Proximal; Oleanolic Acid | 2022 |
Repeated glucose spikes and insulin resistance synergistically deteriorate endothelial function and bardoxolone methyl ameliorates endothelial dysfunction.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Diet, Western; Endothelium, Vascular; Insulin Resistance; Male; Metabolic Syndrome; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Rats, Wistar | 2022 |
Bardoxolone Methyl for Alport Syndrome: Opportunities and Challenges.
Topics: Collagen Type IV; Hematuria; Humans; Kidney; Nephritis, Hereditary; Oleanolic Acid | 2022 |
Bardoxolone Methyl Ameliorates Myocardial Ischemia/Reperfusion Injury by Activating the Nrf2/HO-1 Signaling Pathway.
Topics: Animals; Male; Myocardial Reperfusion Injury; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Signal Transduction | 2023 |
CDDO-Me Abrogates Aberrant Mitochondrial Elongation in Clasmatodendritic Degeneration by Regulating NF-κB-PDI-Mediated S-Nitrosylation of DRP1.
Topics: Animals; Apoptosis; Dynamins; NF-kappa B; Oleanolic Acid; Phosphorylation; Protein Disulfide-Isomerases; Rats | 2023 |
A Point Mutation at C151 of
Topics: Animals; Cysteine; Cytoprotection; Hepatitis; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oleanolic Acid; Point Mutation; Signal Transduction | 2023 |
The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage.
Topics: Animals; Disease Models, Animal; Mice; Necrosis; Neutrophils; NF-E2-Related Factor 2; Oleanolic Acid | 2023 |