oleanolic acid has been researched along with 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 15 (71.43) | 24.3611 |
| 2020's | 4 (19.05) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, J; Ma, H; Wang, Y; Wang, Z; Yao, Z; Yu, J; Zhang, L; Zhang, W; Zhuang, C | 1 |
| Dmitrovsky, E; Gribble, GW; Honda, T; Liby, K; Risingsong, R; Royce, DB; Sporn, MB; Sporn, TA; Williams, CR; Yore, MM | 1 |
| Liby, K; Ma, T; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR; Yore, MM | 1 |
| Beal, MF; Calingasan, NY; Dumont, M; Ho, D; Liby, K; Sporn, M; Stack, C; Wille, E; Williams, C | 1 |
| Brouillet, E; Escartin, C | 1 |
| Hruban, RH; Liby, KT; Maitra, A; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR | 1 |
| Beal, MF; Calingasan, NY; Damiano, M; Kiaei, M; Liby, KT; Naseri, N; Neymotin, A; Petri, S; Risingsong, R; Sporn, M; Wille, E | 1 |
| Baxter, P; Chandran, S; Gupta, K; Hardingham, GE; Hayes, JD; Patani, R; Pedersen, RA; Serio, A; Story, D; Tsujita, T | 1 |
| Lee, HJ; Medici, D; Paul, S; Reddi, AH; Shah, N; Son, AI; Sporn, MB; Suh, N; Yoon, T | 1 |
| Abbate, M; Benigni, A; Carrara, F; Corna, D; Gaspari, F; Locatelli, M; Nava, V; Remuzzi, G; Sangalli, F; Zoja, C | 1 |
| Bumeister, R; Ding, M; Ding, Y; Ferguson, DA; Ma, R; Meyer, CJ; Sprouse, M; Stidham, RD; Trevino, I; Wigley, WC; Winters, A | 1 |
| Bumeister, R; Chin, M; Chuang, JC; Lee, CY; Meyer, C; Sonis, ST; Ward, KW; Wigley, WC | 1 |
| Abboud, HE | 1 |
| Ferguson, DA; McCauley, L; Probst, BL; Trevino, I; Wigley, WC | 1 |
| Cusimano, FA; Getachew, Y; Gopal, P; Reisman, SA; Shay, JW | 1 |
| Bozeman, RG; Kaisani, A; Kim, SB; Kim, W; Richardson, JA; Shay, JW; Wright, WE; Zhang, L | 1 |
| Liu, Y; Ma, JF; Wang, DC; Wang, T; Zhang, CX; Zhou, ZG | 1 |
| Ayi, K; Crowley, VM; Kain, KC; Liby, KT; Lu, Z; Sporn, M | 1 |
| Chen, J; Chen, JS; Gough, NR; He, AR; Latham, PS; Li, S; Lin, P; Malta, TM; Mishra, B; Mishra, L; Mitra, A; Nguyen, BN; Noushmehr, H; Obias, V; Rashid, A; Shin, JH; Song, S; Su, X; Wu, RC; Yao, Z | 1 |
| Dong, Q; Lei, X; Li, H; Li, M; Mao, L; Sun, B; Zhang, Z; Zhao, H | 1 |
| Eisch, AJ; Guzman, CS; Kiffer, FC; Luitel, K; Patel, RA; Shay, JW; Soler, I; Tran, FH; Xiao, R; Yun, S | 1 |
21 other study(ies) available for oleanolic acid and 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide
| Article | Year |
|---|---|
Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors.
Topics: Administration, Oral; Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Female; Humans; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Necroptosis; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Systemic Inflammatory Response Syndrome | 2021 |
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Humans; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Oleanolic Acid; Phosphorylation; STAT3 Transcription Factor; Urethane | 2007 |
Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.
Topics: Adenocarcinoma; Animals; Cell Proliferation; Fatty Acids, Unsaturated; Female; Ligands; Lung Neoplasms; Macrophages; Mice; Mice, Inbred A; Nicotinic Acids; Oleanolic Acid; Rats; Tetrahydronaphthalenes; Urethane | 2009 |
Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease.
Topics: Animals; Antioxidants; Behavioral Symptoms; Brain; Disease Models, Animal; Humans; Huntington Disease; Mice; Mice, Transgenic; Motor Activity; NF-E2-Related Factor 2; Oleanolic Acid; Signal Transduction; Transcriptional Activation | 2010 |
The Nrf2 pathway as a potential therapeutic target for Huntington disease A commentary on "Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington disease"
Topics: Animals; Brain; Cytoprotection; Disease Models, Animal; Drug Discovery; Heme Oxygenase-1; Humans; Huntington Disease; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Signal Transduction; Transcriptional Activation | 2010 |
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; Mice; Mice, Transgenic; Nicotinic Acids; Oleanolic Acid; Pancreatic Neoplasms; Signal Transduction; Tetrahydronaphthalenes | 2010 |
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cell Nucleus; Disease Models, Animal; Inflammation; Major Histocompatibility Complex; Mice; Mice, Transgenic; Mitochondria; Neurodegenerative Diseases; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Proteins; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Vesicular Transport Proteins | 2011 |
Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.
Topics: Animals; Astrocytes; Cell Line; Cell Survival; Cells, Cultured; Embryonic Stem Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Hydrogen Peroxide; Immunohistochemistry; Mice; Mice, Mutant Strains; Neural Stem Cells; NF-E2-Related Factor 2; Oleanolic Acid | 2012 |
Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chondrogenesis; Collagen Type II; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Imidazoles; Mesenchymal Stem Cells; Mice; Oleanolic Acid; Organ Culture Techniques; Proteoglycans; Real-Time Polymerase Chain Reaction; Skull | 2012 |
Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Chromatography, Liquid; Diabetic Nephropathies; Disease Models, Animal; Diuresis; Drinking; Hemodynamics; Kidney; Liver; Male; Mass Spectrometry; Oleanolic Acid; Ramipril; Rats; Rats, Zucker; Renal Circulation; Triterpenes | 2013 |
The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II-induced contraction of glomerular mesangial cells.
Topics: Angiotensin II; Animals; Calcium; Cell Shape; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Regulation; Glomerular Filtration Rate; Hemodynamics; Humans; Hydrogen Peroxide; Inulin; Male; Mesangial Cells; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Renal Circulation; Time Factors | 2013 |
Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.
Topics: Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Eating; Glucose; Kidney; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oleanolic Acid; Rats; Rats, Zucker | 2013 |
Synthetic oleanane triterpenoids: magic bullets or not?
Topics: Angiotensin II; Animals; Cell Shape; Glomerular Filtration Rate; Humans; Male; Mesangial Cells; Oleanolic Acid | 2013 |
Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; MCF-7 Cells; Mice; Neoplasms; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2015 |
The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Cell Line, Tumor; Cytochrome P-450 CYP2E1; Cytokines; Disease Progression; Humans; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid | 2016 |
Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.
Topics: Adenomatous Polyposis Coli; Aging; Animals; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; DNA Damage; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Mice, Inbred C57BL; Mice, Knockout; Mutation; Oleanolic Acid; Oxidative Stress; Proton Therapy; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Tumor Suppressor Protein p53; Whole-Body Irradiation | 2016 |
Protective effect of CDDO-ethyl amide against high-glucose-induced oxidative injury via the Nrf2/HO-1 pathway.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Cytoprotection; Glucose; Heme Oxygenase-1; NF-E2-Related Factor 2; Nucleus Pulposus; Oleanolic Acid; Oxidative Stress; Rabbits; Reactive Oxygen Species | 2017 |
Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria.
Topics: Animals; Antimalarials; Blood-Brain Barrier; Endothelium; Female; Inflammation; Longevity; Malaria, Cerebral; Male; Mice, Inbred C57BL; Oleanolic Acid; Rats | 2017 |
Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Exome Sequencing; Gene Deletion; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Heterografts; Humans; Liver Neoplasms; Mice; Mice, Nude; Neoplastic Stem Cells; Oleanolic Acid; Phosphorylation; RNA, Small Interfering; Smad Proteins; Smad2 Protein; Smad3 Protein; Spectrin; Stem Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ubiquitin-Protein Ligases; Ubiquitination; Up-Regulation | 2020 |
The novel Nrf2 activator CDDO-EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice.
Topics: Animals; Brain Ischemia; Cells, Cultured; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; NF-E2-Related Factor 2; Oleanolic Acid; Phenotype | 2021 |
Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Cosmic Radiation; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Radiation Exposure; Recognition, Psychology; Social Behavior | 2022 |