Page last updated: 2024-09-04

oleanolic acid 3-acetate and oleanolic acid

oleanolic acid 3-acetate has been researched along with oleanolic acid in 17 studies

Compound Research Comparison

Studies
(oleanolic acid 3-acetate)
Trials
(oleanolic acid 3-acetate)
Recent Studies (post-2010)
(oleanolic acid 3-acetate)
Studies
(oleanolic acid)
Trials
(oleanolic acid)
Recent Studies (post-2010) (oleanolic acid)
360244,169312,404

Protein Interaction Comparison

ProteinTaxonomyoleanolic acid 3-acetate (IC50)oleanolic acid (IC50)
Aldo-keto reductase family 1 member B10Homo sapiens (human)2.045
Phospholipase A2Homo sapiens (human)3
DNA polymerase betaHomo sapiens (human)6.8667
DNA polymerase betaRattus norvegicus (Norway rat)5.6
Receptor-type tyrosine-protein phosphatase CHomo sapiens (human)1
Receptor-type tyrosine-protein phosphatase FHomo sapiens (human)3.065
Tissue factorHomo sapiens (human)0.005
Tyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)4.38
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)2.8444
Liver carboxylesterase 1Homo sapiens (human)0.1
Tyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)3.065
M-phase inducer phosphatase 2Homo sapiens (human)0.98
Dual specificity protein phosphatase 3Homo sapiens (human)5.4
Transcription factor p65Homo sapiens (human)2.4
Tyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)3.065
Protease Human immunodeficiency virus 18

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's3 (17.65)29.6817
2010's12 (70.59)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Assefa, H; Nimrod, A; Sindelar, R; Walker, L1
Desjardins, AE; Kim, NC; Kinghorn, AD; Wu, CD1
Bore, L; Favaloro, FG; Finlay, HJ; Gribble, GW; Honda, T; Rounds, BV; Sporn, MB; Suh, N; Wang, Y1
Begum, S; Gilani, AH; Shaheen, F; Siddiqui, BS; Sultana, I1
Chen, J; Hua, W; Liu, J; Sun, H; Wu, G; Wu, X; Zhang, L1
Chen, K; Huang, X; Peng, Y; Qiu, Y; Shi, Y; Sun, D; Wang, H; Wang, Q; Xiao, S; Yu, F; Yu, M; Zhang, C; Zhang, L; Zhang, Z; Zhao, C; Zheng, Y; Zhou, D; Zhu, L1
Albericio, F; Garcia-Granados, A; Lupiañez, JA; Martin-Fonseca, S; Martinez, A; Medina-O'Donnell, M; Parra, A; Reyes-Zurita, FJ; Rivas, F1
Bhandari, P; Bhutani, KK; Gangwal, RP; Patel, NK; Sangamwar, AT1
Camici, G; de la Rosa-Lugo, V; Estrada-Soto, S; Flores-Morales, V; Hidalgo-Figueroa, S; Navarrete-Vázquez, G; Paoli, P; Ramírez-Espinosa, JJ; Rios, MY1
Ferrer-Martín, RM; Garcia-Granados, A; Lupiañez, JA; Martin-Fonseca, S; Martinez, A; Medina-O'Donnell, M; Parra, A; Reyes-Zurita, FJ; Rivas, F1
Cao, G; Chang, Y; Chen, D; He, X; Huang, X; Liu, J; Luo, H; Ni, S; Shen, Q; Sun, H; Wang, P; Wen, X; Zhou, H1
Deng, Y; Li, CH; Wu, T; Zhai, SQ1
Chen, Z; Cheng, YY; Duan, HQ; Goto, M; Huang, KY; Lee, KH; Ling, Y; Liu, YL; Morris-Natschke, SL; Tong, XH; Yang, PC; Yang, SL1
Dhar, JK; Khan, I; Koul, S; Sangwan, PL1
Gao, L; Lin, CZ; Zhao, ZX; Zhu, CC1
Bednarczyk-Cwynar, B1
Hwang, JT; Kang, W; Kim, E; Lee, SJ; Lee, SW; Noh, K; Rho, MC; Shin, B1

Reviews

1 review(s) available for oleanolic acid 3-acetate and oleanolic acid

ArticleYear
Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Animals; Antiprotozoal Agents; Drug Discovery; Female; Humans; Pregnancy; Toxoplasma; Toxoplasmosis

2019

Other Studies

16 other study(ies) available for oleanolic acid 3-acetate and oleanolic acid

ArticleYear
Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid.
    Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

    Topics: Antineoplastic Agents; Apoptosis; Complement Inactivator Proteins; DNA Fragmentation; Drug Evaluation, Preclinical; Humans; Melanoma; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured

1999
Activity of triterpenoid glycosides from the root bark of Mussaenda macrophylla against two oral pathogens.
    Journal of natural products, 1999, Volume: 62, Issue:10

    Topics: Carbohydrate Sequence; Glycosides; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Sequence Data; Mouth; Plant Roots; Porphyromonas gingivalis; Rubiaceae; Spectrum Analysis; Triterpenes

1999
Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages.
    Journal of medicinal chemistry, 2000, May-04, Volume: 43, Issue:9

    Topics: Animals; Drug Design; Female; In Vitro Techniques; Indicators and Reagents; Interferon-gamma; Macrophages; Magnetic Resonance Spectroscopy; Mice; Nitric Oxide; Receptors, Glucocorticoid; Recombinant Proteins; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

2000
Structure and spasmolytic activity of eucalyptanoic acid from Eucalyptus camaldulensis var. obtusa and synthesis of its active derivative from oleanolic acid.
    Journal of natural products, 2002, Volume: 65, Issue:12

    Topics: Acetylation; Animals; Chromatography, Thin Layer; Eucalyptus; Jejunum; Methylation; Molecular Structure; Muscle Contraction; Muscle, Smooth; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pakistan; Parasympatholytics; Plant Leaves; Plants, Medicinal; Stereoisomerism; Triterpenes

2002
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
    Bioorganic & medicinal chemistry letters, 2006, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Blood Glucose; Cyclization; Enzyme Inhibitors; Glycogen Phosphorylase; Hyperglycemia; Mice; Molecular Structure; Muscles; Oleanolic Acid; Rabbits; Structure-Activity Relationship; Triterpenes

2006
Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.
    Journal of medicinal chemistry, 2013, Jun-13, Volume: 56, Issue:11

    Topics: Animals; Antiviral Agents; Cell Line, Tumor; Cytotoxins; HEK293 Cells; Hemolytic Agents; Hepacivirus; Humans; Oleanolic Acid; Rabbits; Structure-Activity Relationship; Virus Internalization

2013
Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents.
    European journal of medicinal chemistry, 2014, Mar-03, Volume: 74

    Topics: Acylation; Anti-HIV Agents; Antineoplastic Agents; Apoptosis; Industrial Waste; Olive Oil; Plant Oils; Reactive Oxygen Species; Triterpenes

2014
Oleanolic acid analogs as NO, TNF-α and IL-1β inhibitors: synthesis, biological evaluation and docking studies.
    Bioorganic & medicinal chemistry letters, 2014, Sep-01, Volume: 24, Issue:17

    Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Interleukin-1beta; Mice; Molecular Docking Simulation; Molecular Structure; Nitric Oxide; Oleanolic Acid; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2014
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: Animals; Binding Sites; Chemistry Techniques, Synthetic; Computer Simulation; Enzyme Inhibitors; Hypoglycemic Agents; Male; Molecular Docking Simulation; Oleanolic Acid; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats

2014
Semi-synthesis and antiproliferative evaluation of PEGylated pentacyclic triterpenes.
    European journal of medicinal chemistry, 2016, Aug-08, Volume: 118

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Drug Design; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Mice; Pentacyclic Triterpenes; Polyethylene Glycols

2016
Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors.
    European journal of medicinal chemistry, 2017, Oct-20, Volume: 139

    Topics: Animals; Cholesterol Ester Transfer Proteins; Dose-Response Relationship, Drug; Drug Discovery; Esters; Guinea Pigs; Humans; Mice; Mice, Transgenic; Molecular Structure; Structure-Activity Relationship; Triterpenes

2017
Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
    Journal of natural products, 2019, 11-22, Volume: 82, Issue:11

    Topics: A549 Cells; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Design; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Nitric Oxide; Nitric Oxide Donors; Oleanolic Acid; Protein Kinase Inhibitors

2019
Simultaneous quantification of five marker compounds of Betula utilis stem bark using a validated high-performance thin-layer chromatography method.
    Journal of separation science, 2012, Volume: 35, Issue:3

    Topics: Betula; Chromatography, High Pressure Liquid; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Plant Extracts; Plant Stems; Sitosterols; Triterpenes

2012
Triterpenes from Callicarpa integerrima Champ.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:1

    Topics: Betulinic Acid; Callicarpa; Molecular Conformation; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Plant Stems; Plants, Medicinal; Saponins; Triterpenes; Ursolic Acid

2012
Anilides and toluidides of 3beta-acetyloleanolic acid.
    Natural product communications, 2012, Volume: 7, Issue:4

    Topics: Anilides; Molecular Structure; Oleanolic Acid; Triterpenes

2012
Simultaneous determination of 3-O-acetyloleanolic acid and oleanolic acid in rat plasma using liquid chromatography coupled to tandem mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2016, Jan-25, Volume: 118

    Topics: Animals; Chromatography, Liquid; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triterpenes

2016