oleanane and 23-hydroxybetulinic-acid

oleanane has been researched along with 23-hydroxybetulinic-acid* in 1 studies

Other Studies

1 other study(ies) available for oleanane and 23-hydroxybetulinic-acid

Article	Year
Synthesis and biological evaluation of ambradiolic acid as an inhibitor of glycogen phosphorylase. Fitoterapia, 2015, Volume: 100 Ambradiolic acid (3) with oleanane skeleton is a natural pentacyclictriterpene. The first synthesis of 3 starting from 23-hydroxybetulinic acid (2) has been accomplished in 12-steps with a total yield of 18.1% in our study. Compound 3 was further biologically evaluated and found to exhibit significant inhibitory activity against rabbit muscle glycogen phosphorylase (GP) with an IC50 value of 12.4 μM, suggesting it could be a potential lead compound for the development of hypoglycemic drugs. Topics: Animals; Enzyme Inhibitors; Glycogen Phosphorylase; Molecular Structure; Muscle, Skeletal; Oleanolic Acid; Pentacyclic Triterpenes; Rabbits; Structure-Activity Relationship; Triterpenes	2015

Article

Year

Synthesis and biological evaluation of ambradiolic acid as an inhibitor of glycogen phosphorylase.

Fitoterapia, 2015, Volume: 100

Ambradiolic acid (3) with oleanane skeleton is a natural pentacyclictriterpene. The first synthesis of 3 starting from 23-hydroxybetulinic acid (2) has been accomplished in 12-steps with a total yield of 18.1% in our study. Compound 3 was further biologically evaluated and found to exhibit significant inhibitory activity against rabbit muscle glycogen phosphorylase (GP) with an IC50 value of 12.4 μM, suggesting it could be a potential lead compound for the development of hypoglycemic drugs.

Topics: Animals; Enzyme Inhibitors; Glycogen Phosphorylase; Molecular Structure; Muscle, Skeletal; Oleanolic Acid; Pentacyclic Triterpenes; Rabbits; Structure-Activity Relationship; Triterpenes

2015