olanzapine and hydroxypropylmethylcellulose-acetate-succinate

Amorphous solid dispersions (ASDs) of class II and IV biopharmaceutics classification system drugs in water-miscible polymers are a well-recognized means of enhancing dissolution, while such dispersions in hydrophobic polymers form the basis of micro- and nanoparticulate technologies. However, drug recrystallization presents significant problems for product development, and the mechanisms and pathways involved are poorly understood. Here, we outline the use of combined differential scanning calorimetry (DSC)-synchrotron X-ray diffraction to monitor the sequential appearance of polymorphs of olanzapine (OLZ) when dispersed in a range of polymers. In a recent study (

Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Drug Compounding; Drug Liberation; Hot Temperature; Hydrophobic and Hydrophilic Interactions; Methylcellulose; Olanzapine; Polyesters; Polyglactin 910; Solubility; X-Ray Diffraction