okadaic-acid and alpha-carboline

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss, and behavioral disturbances, ultimately resulting in death. The critical roles of glycogen synthase kinase-3β (GSK-3β) in tau pathology have also received considerable attention. Based on molecular docking studies, a series of novel α-carboline derivatives were designed, synthesized, and evaluated as GSK-3β inhibitors for their various biological activities. Among them, compound ZCH-9 showed the most potent inhibitory activity against GSK-3β, with an IC

Topics: Alzheimer Disease; Carbolines; Glycogen Synthase Kinase 3 beta; Humans; Molecular Docking Simulation; Neuroblastoma; Neurodegenerative Diseases; Okadaic Acid; Phosphorylation; Structure-Activity Relationship; tau Proteins