Compounds > ofloxacin n-oxide
Page last updated: 2024-09-04

ofloxacin n-oxide and ofloxacin

ofloxacin n-oxide has been researched along with ofloxacin in 6 studies

*Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION. [MeSH]

*Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION. [MeSH]

Compound Research Comparison

Studies
(ofloxacin n-oxide)		Trials
(ofloxacin n-oxide)		Recent Studies (post-2010)
(ofloxacin n-oxide)		Studies
(ofloxacin)		Trials
(ofloxacin)		Recent Studies (post-2010) (ofloxacin)
6006,4849761,346

Protein Interaction Comparison

ProteinTaxonomyofloxacin n-oxide (IC50)ofloxacin (IC50)
DNA gyrase subunit AEscherichia coli K-121.5
DNA gyrase subunit BEscherichia coli K-121.5

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's2 (33.33)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hakusui, H; Kurata, T; Okazaki, O; Tachizawa, H1
Flor, S1
MacGowan, AP; Mackay, IG; Reeves, DS; White, LO1
Lovering, AM; MacGowan, AP; Mackay, IG; Reeves, DS; White, LO1
Bowker, KA; Körner, RJ; MacGowan, AP; McMullin, CM; Reeves, DS; White, LO1
Blaschke, G; Horstkötter, C1

Other Studies

6 other study(ies) available for ofloxacin n-oxide and ofloxacin

ArticleYear
Species-related stereoselective disposition of ofloxacin in the rat, dog and monkey.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:4

    Topics: Administration, Oral; Animals; Anti-Infective Agents; Dogs; Female; Fluoroquinolones; Inactivation, Metabolic; Injections, Intravenous; Kidney; Macaca fascicularis; Male; Metabolic Clearance Rate; Ofloxacin; Rats; Species Specificity; Stereoisomerism; Substrate Specificity

1992
Pharmacokinetics of ofloxacin. An overview.
    The American journal of medicine, 1989, Dec-29, Volume: 87, Issue:6C

    Topics: Absorption; Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Creatinine; Double-Blind Method; Female; Fluoroquinolones; Humans; Infusions, Intravenous; Kidney Diseases; Male; Middle Aged; Ofloxacin; Placebos

1989
The pharmacokinetics of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide in haemodialysis patients with end-stage renal failure.
    The Journal of antimicrobial chemotherapy, 1988, Volume: 22 Suppl C

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Chromatography, High Pressure Liquid; Female; Fluoroquinolones; Humans; Kidney Failure, Chronic; Male; Middle Aged; Ofloxacin; Renal Dialysis

1988
A preliminary report on the pharmacokinetics of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide in patients with chronic renal failure.
    Drugs, 1987, Volume: 34 Suppl 1

    Topics: Anti-Infective Agents; Chromatography, High Pressure Liquid; Fluoroquinolones; Humans; Kidney Failure, Chronic; Microbial Sensitivity Tests; Ofloxacin; Oxazines

1987
The serum concentrations of desmethyl ofloxacin and ofloxacin N-oxide in seriously ill patients and their possible contributions to the antibacterial activity of ofloxacin.
    The Journal of antimicrobial chemotherapy, 1994, Volume: 34, Issue:2

    Topics: Anti-Infective Agents; Bacteria; Bacterial Infections; Fluoroquinolones; Humans; Ofloxacin

1994
Stereoselective determination of ofloxacin and its metabolites in human urine by capillary electrophoresis using laser-induced fluorescence detection.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Apr-15, Volume: 754, Issue:1

    Topics: Administration, Oral; Anti-Infective Agents; Electrophoresis, Capillary; Fluorescence; Fluoroquinolones; Humans; Lasers; Molecular Structure; Ofloxacin; Sensitivity and Specificity; Stereoisomerism

2001