ofloxacin and warfarin

ofloxacin has been researched along with warfarin in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (8.11)	18.7374
1990's	4 (10.81)	18.2507
2000's	21 (56.76)	29.6817
2010's	9 (24.32)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Gozalbes, R; Pineda-Lucena, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Howard, BM; Lewin, CS; Smith, JT	1
Bia, FJ; Divo, AA; Patton, CL; Sartorelli, AC	1
Breyer, S; Georgopoulos, A; Hirschl, AM; Rotter, ML; Stanek, G	1
Leor, J; Matetzki, S	1
Howard, BM; Pinney, RJ; Smith, JT	1
Ashar, BH; Baciewicz, AM; Locke, TW	1
Fowler, C; Liao, S; Nayak, RK; Palmer, M	1
Locke, C; Ravnan, SL	1
Cinetto, L; Gheno, G	1
Fugate, SE; Jones, CB	1
Burrows, MM; Enlow, AM; Greenwood, MC; Kilpatrick, DM; Lower, DL; Yamreudeewong, W	1
Fugit, RV; Glasheen, JJ; Prochazka, AV	2
Anderson, HG; McCall, KL; Scott, JC	1
Bell, CM; Kopp, A; Mamdami, MM; Stroud, LF	1
Cole, J; Mathews, S; Ryono, RA	1
Glasheen, JJ; Prochazka, AV	2
Ismail, HM; Smalligan, RD; Vadlamudi, RS	1
Ahmed, A; Fay, WP; Kaus, CA; Stephens, JC	1
Carroll, DG; Carroll, DN	1
Gracia García, B; Jodar Masanés, R; Leiva Badosa, E; Mercadal Orfila, G; Perayre Badía, M; Reynaldo Martínez, C	1
Abe, Y; Ikegami, Y; Nemoto, C; Shimada, J; Tase, C; Tsukada, Y	1
Bomgaars, LR; Kim, S; Moffett, BS	1

Reviews

2 review(s) available for ofloxacin and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Interactions between warfarin and three commonly prescribed fluoroquinolones. The Annals of pharmacotherapy, 2008, Volume: 42, Issue:5 Topics: Aza Compounds; Ciprofloxacin; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Fluoroquinolones; Humans; International Normalized Ratio; Levofloxacin; Moxifloxacin; Ofloxacin; Quinolines; Warfarin	2008

Trials

3 trial(s) available for ofloxacin and warfarin

Article	Year
Absence of an effect of levofloxacin on warfarin pharmacokinetics and anticoagulation in male volunteers. Journal of clinical pharmacology, 1996, Volume: 36, Issue:11 Topics: Administration, Oral; Adult; Anti-Infective Agents; Anticoagulants; Blood Coagulation; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Humans; Levofloxacin; Liver; Male; Ofloxacin; Warfarin	1996
Impact of preemptive warfarin dose reduction on anticoagulation after initiation of trimethoprim-sulfamethoxazole or levofloxacin. Journal of thrombosis and thrombolysis, 2008, Volume: 26, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Anticoagulants; Blood Coagulation; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Female; Humans; International Normalized Ratio; Levofloxacin; Male; Middle Aged; Ofloxacin; Trimethoprim, Sulfamethoxazole Drug Combination; Warfarin	2008
Readmissions for warfarin-related bleeding in pediatric patients after hospital discharge. Pediatric blood & cancer, 2013, Volume: 60, Issue:9 Topics: Adolescent; Anti-Bacterial Agents; Anticoagulants; Asian; Cardiac Surgical Procedures; Child; Child, Preschool; Citalopram; Female; Hospital Information Systems; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Patient Readmission; Postoperative Hemorrhage; Risk Factors; Selective Serotonin Reuptake Inhibitors; Time Factors; Warfarin	2013

Other Studies

32 other study(ies) available for ofloxacin and warfarin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
4-Quinolone interactions with gyrase subunit B inhibitors. Journal of medical microbiology, 1991, Volume: 35, Issue:6 Topics: Aminocoumarins; Anti-Infective Agents; Coumarins; Dose-Response Relationship, Drug; Drug Interactions; Microbial Sensitivity Tests; Novobiocin; Ofloxacin; Staphylococcus aureus; Topoisomerase II Inhibitors	1991
Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:8 Topics: Aminocoumarins; Animals; Anti-Infective Agents; Chloroquine; Ciprofloxacin; Coumarins; Drug Interactions; Drug Resistance; Enoxacin; Fluoroquinolones; Nalidixic Acid; Norfloxacin; Novobiocin; Ofloxacin; Oxolinic Acid; Pefloxacin; Plasmodium falciparum; Tetracycline; Topoisomerase II Inhibitors	1988
Efficacy of coumermycin, ofloxacin and vancomycin against methicillin-resistant Staphylococcus aureus in vitro and in experimental infections of mice. Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology, 1988, Volume: 267, Issue:4 Topics: Aminocoumarins; Animals; Anti-Bacterial Agents; Coumarins; Drug Resistance, Microbial; Male; Methicillin; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Ofloxacin; Oxazines; Staphylococcal Infections; Staphylococcus aureus; Vancomycin	1988
Ofloxacin and warfarin. Annals of internal medicine, 1988, Nov-01, Volume: 109, Issue:9 Topics: Adult; Blood Coagulation; Drug Interactions; Female; Humans; Ofloxacin; Warfarin	1988
Antagonism between bactericidal activities of 4-quinolones and coumarins gives insight into 4-quinolone killing mechanisms. Microbios, 1994, Volume: 77, Issue:311 Topics: Aminocoumarins; Anti-Infective Agents; Ciprofloxacin; Coumarins; DNA Topoisomerases, Type II; Escherichia coli; Genes, Bacterial; Microbial Sensitivity Tests; Mutation; Nalidixic Acid; Norfloxacin; Novobiocin; Ofloxacin; Rifampin	1994
Interaction of ofloxacin and warfarin. Annals of internal medicine, 1993, Dec-15, Volume: 119, Issue:12 Topics: Aged; Drug Interactions; Female; Hematuria; Humans; Ofloxacin; Prothrombin Time; Warfarin	1993
Levofloxacin and warfarin interaction. Pharmacotherapy, 2001, Volume: 21, Issue:7 Topics: Aged; Anti-Infective Agents; Anticoagulants; Blood Coagulation; Drug Interactions; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Warfarin	2001
Levofloxacin-warfarin interaction. European journal of clinical pharmacology, 2001, Volume: 57, Issue:5 Topics: Administration, Oral; Aged; Anti-Infective Agents; Anticoagulants; Drug Interactions; Female; Follow-Up Studies; Hemorrhage; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Warfarin	2001
Levofloxacin and warfarin interaction. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anticoagulants; Drug Administration Schedule; Drug Synergism; Female; Humans; International Normalized Ratio; Levofloxacin; Male; Middle Aged; Ofloxacin; Prothrombin Time; Warfarin	2002
Effect of levofloxacin coadministration on the international normalized ratios during warfarin therapy. Pharmacotherapy, 2003, Volume: 23, Issue:3 Topics: Aged; Aged, 80 and over; Drug Interactions; Drug Therapy, Combination; Female; Hospitals, Veterans; Humans; International Normalized Ratio; Levofloxacin; Male; Middle Aged; Ofloxacin; Warfarin	2003
Effect of levofloxacin coadministration on the international normalized ratios during warfarin therapy--a comment. Pharmacotherapy, 2003, Volume: 23, Issue:8 Topics: Anticoagulants; Drug Interactions; Drug Therapy, Combination; Humans; International Normalized Ratio; Levofloxacin; Ofloxacin; Warfarin	2003
Retrospective evaluation of a possible interaction between warfarin and levofloxacin. Pharmacotherapy, 2005, Volume: 25, Issue:1 Topics: Aged; Body Temperature; Data Collection; Drug Administration Schedule; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Felodipine; Female; Humans; International Normalized Ratio; Levofloxacin; Male; Medical Records; Middle Aged; Ofloxacin; Outpatients; Randomized Controlled Trials as Topic; Retrospective Studies; Time Factors; Treatment Outcome; Warfarin	2005
The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens. Journal of general internal medicine, 2005, Volume: 20, Issue:7 Topics: Administration, Oral; Aged; Anti-Infective Agents; Anticoagulants; Azithromycin; Cohort Studies; Drug Interactions; Female; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Platelet Aggregation Inhibitors; Prazosin; Retrospective Studies; Trimethoprim, Sulfamethoxazole Drug Combination; Warfarin	2005
The safety of levofloxacin in elderly patients on warfarin. The American journal of medicine, 2005, Volume: 118, Issue:12 Topics: Acute Disease; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticoagulants; Case-Control Studies; Drug Interactions; Female; Hemorrhage; Humans; Levofloxacin; Male; Odds Ratio; Ofloxacin; Ontario; Thrombosis; Warfarin	2005
Anticoagulation-related outcomes in patients receiving warfarin after starting levofloxacin or gatifloxacin. Pharmacotherapy, 2006, Volume: 26, Issue:10 Topics: Aged; Anticoagulants; Databases as Topic; Drug Monitoring; Drug Therapy, Combination; Female; Fluoroquinolones; Gatifloxacin; Hospitals, Veterans; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Retrospective Studies; Risk Assessment; Risk Factors; Treatment Outcome; United States; Warfarin	2006
The safety of levofloxacin in patients on warfarin. The American journal of medicine, 2007, Volume: 120, Issue:4 Topics: Anti-Bacterial Agents; Anticoagulants; Drug Interactions; Hemorrhage; Humans; International Normalized Ratio; Levofloxacin; Ofloxacin; Thrombosis; Warfarin	2007
Interaction between warfarin and levofloxacin: case series. Southern medical journal, 2007, Volume: 100, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticoagulants; Drug Interactions; Female; Hemorrhage; Humans; Levofloxacin; Male; Ofloxacin; Pericardial Effusion; Retroperitoneal Space; Warfarin	2007
Further evidence of a clinically significant levofloxacin-warfarin interaction. Southern medical journal, 2008, Volume: 101, Issue:6 Topics: Anti-Bacterial Agents; Anticoagulants; Drug Interactions; Hemorrhage; Humans; International Normalized Ratio; Levofloxacin; Ofloxacin; Risk Factors; Warfarin	2008
Retrospective assessment of potential interaction between levofloxacin and warfarin. Pharmacy world & science : PWS, 2009, Volume: 31, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticoagulants; Biomarkers; Drug Interactions; Female; Humans; Inpatients; International Normalized Ratio; Levofloxacin; Male; Middle Aged; Ofloxacin; Retrospective Studies; Time Factors; Warfarin	2009
Acute renal failure caused by severe coagulopathy induced by the interaction between warfarin potassium and levofloxacin: a case report. Journal of anesthesia, 2012, Volume: 26, Issue:6 Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Anticoagulants; Blood Coagulation Disorders; Cardiomyopathy, Dilated; Drug Interactions; Hematuria; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Shock; Urinary Tract Infections; Warfarin	2012