ofloxacin and theophylline

ofloxacin has been researched along with theophylline in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (42.22)	18.7374
1990's	4 (8.89)	18.2507
2000's	8 (17.78)	29.6817
2010's	14 (31.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, J; Chen, X; Huang, L; Li, X; Sun, Y	1
Huang, L; Li, X; Meng, F; Miao, H; Sun, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL	1
An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T	1
Chyrek-Borowska, S; Michalska, I; Siergiejko, Z; Szymański, W	1
Petermann, W	1
Nakanishi, S; Okuno, H	1
Fujita, K; Fujita, Y; Mori, I; Nakahashi, Y; Tanaka, T	1
Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, GJ	1
Goto, M; Kawakatsu, K; Sano, M; Takeyama, M; Yamamoto, I; Yamashina, H	1
Beer, C; Harder, S; Papenburg, A; Shah, PM; Staib, AH; Stille, W	1
Rehavi, M; Rubinstein, E; Segev, S	1
Vree, TB; Wijnands, WJ	1
Al-Turk, WA; Awidi, AS; Khalaf, RM; Othman, S; Shaheen, OM	1
Mulder, GJ; Nagelkerke, JF; Tijdens, RB; Van der Mark, EJ; Wijnands, WJ	1
Goto, M; Kawakatsu, K; Ohkita, C; Sano, M; Takeyama, M; Yamamoto, I; Yamashina, H	1
De Witte, TM; Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, WJ	1
Drew, RH; Gallis, HA	1
Beck, S; Fourtillan, JB; Granier, J; Saint-Salvi, B; Salmon, J; Surjus, A; Tremblay, D; Vincent Du Laurier, M	1
Baur, C; Davies, BI; Maesen, FP; Sumajow, CA	1
Freer, JP; Grasela, TH; Gregoire, SL; Schentag, JJ; Tack, KJ	1
Goto, M; Sano, M; Ueda, J; Yamamoto, I; Yamashina, H; Yoshikawa, E	1
Kawane, H; Niki, Y; Soejima, R; Sumi, M; Umeki, S	1
Miyazaki, K; Okazaki, O; Tachizawa, H	1
Baars, AM; van Herwaarden, CL; Vree, TB; Wijnands, WJ	2
Curtin, CR; Fowler, CL; Gisclon, LG; Hafkin, B; Natarajan, J; Williams, RR	1
Enomoto, H; Hasegawa, A; Kawana, H; Kitada, M; Kuriyama, T; Nakamura, H; Ohmori, S; Ohtsuka, T	1
Abd El-Aty, AM; Kubota, R; Regmi, NL; Shimoda, M; Tomita, A	1
Bellon, A; Chacko, RC; Coverdale, JH; Perez-Garcia, G	1
Hu, N; Liu, L; Liu, X; Pan, X; Wang, G; Wang, P; Xie, L	1
Cheng, JL; Fan, HW; Liu, HY; Liu, L; Liu, XD; Pan, X; Xiao, DW; Xie, L; Yang, HW	1
Iwanaga, K; Kakemi, M; Kawai, M; Miyazaki, M	1

Reviews

4 review(s) available for ofloxacin and theophylline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Interaction between the fluoroquinolones and the bronchodilator theophylline. The Journal of antimicrobial chemotherapy, 1988, Volume: 22 Suppl C Topics: Anti-Infective Agents; Drug Interactions; Humans; Ofloxacin; Theophylline	1988
Ofloxacin: its pharmacology, pharmacokinetics, and potential for clinical application. Pharmacotherapy, 1988, Volume: 8, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Ofloxacin; Oxazines; Random Allocation; Theophylline	1988
Seizures associated with levofloxacin: case presentation and literature review. European journal of clinical pharmacology, 2009, Volume: 65, Issue:10 Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Cytochrome P-450 CYP1A2; Dopamine Antagonists; Drug Administration Schedule; Drug Synergism; Female; Humans; Klebsiella Infections; Levofloxacin; Male; Metoclopramide; Mianserin; Middle Aged; Mirtazapine; Ofloxacin; Phosphodiesterase Inhibitors; Seizures; Theophylline	2009

Trials

6 trial(s) available for ofloxacin and theophylline

Article	Year
[Effect of ofloxacin, ciprofloxacin and nalidixic acid on serum theophylline level in patients treated with methylxanthine preparations]. Pneumonologia i alergologia polska, 1992, Volume: 60, Issue:1-2 Topics: Administration, Oral; Adult; Aminophylline; Asthma; Biological Availability; Ciprofloxacin; Drug Therapy, Combination; Humans; Middle Aged; Nalidixic Acid; Ofloxacin; Theophylline; Time Factors	1992
4-quinolones inhibit biotransformation of caffeine. European journal of clinical pharmacology, 1988, Volume: 35, Issue:6 Topics: Adult; Biotransformation; Caffeine; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Interactions; Enoxacin; Humans; Male; Molecular Structure; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones; Random Allocation; Theophylline	1988
Ofloxacin: its pharmacology, pharmacokinetics, and potential for clinical application. Pharmacotherapy, 1988, Volume: 8, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Ofloxacin; Oxazines; Random Allocation; Theophylline	1988
Clinical, microbiological and pharmacokinetic studies on ofloxacin in acute purulent exacerbations of chronic respiratory disease. The Journal of antimicrobial chemotherapy, 1986, Volume: 18, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Bacterial Infections; Chronic Disease; Drug Therapy, Combination; Female; Humans; Kinetics; Male; Middle Aged; Ofloxacin; Oxazines; Respiratory Tract Infections; Sputum; Theophylline	1986
Absence of a pharmacokinetic interaction between intravenous theophylline and orally administered levofloxacin. Journal of clinical pharmacology, 1997, Volume: 37, Issue:8 Topics: Adult; Anti-Infective Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Half-Life; Humans; Injections, Intravenous; Levofloxacin; Male; Ofloxacin; Theophylline	1997
Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans. Acta pharmacologica Sinica, 2011, Volume: 32, Issue:10 Topics: Adult; Anti-Bacterial Agents; Bronchodilator Agents; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Female; Humans; Male; Microsomes, Liver; Ofloxacin; Theophylline; Young Adult	2011

Other Studies

36 other study(ies) available for ofloxacin and theophylline

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids. Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23 Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine	2013
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease. European journal of medicinal chemistry, 2014, Nov-24, Volume: 87 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Inhibitory Concentration 50; Ligands; Peptide Fragments; Permeability; Protein Aggregates	2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species	2017
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2019, Feb-01, Volume: 163 Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram	2019
Ofloxacin in lower respiratory tract infections. Infection, 1991, Volume: 19 Suppl 7 Topics: Bacterial Infections; Bronchitis; Chronic Disease; Cross Infection; Drug Administration Schedule; Drug Interactions; Humans; Microbial Sensitivity Tests; Ofloxacin; Pneumonia; Theophylline	1991
Comparison of inhibitory effects of new quinolones on drug metabolizing activity in the liver. Japanese journal of pharmacology, 1990, Volume: 53, Issue:1 Topics: Acetaminophen; Animals; Anti-Infective Agents; Enoxacin; Glutathione; Liver; Liver Function Tests; Male; Microsomes, Liver; Mixed Function Oxygenases; Norfloxacin; Ofloxacin; Rats; Theophylline	1990
Determination of chlorpromazine, thiamine, lincomycin, ofloxacin and theophylline by ternary complex formation with eosin and palladium(II). Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:12 Topics: Chemical Phenomena; Chemistry; Chlorpromazine; Eosine Yellowish-(YS); Lincomycin; Ofloxacin; Oxazines; Palladium; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Thiamine	1987
Drug-drug interactions affecting fluoroquinolones. The American journal of medicine, 1989, Dec-29, Volume: 87, Issue:6C Topics: Adult; Drug Interactions; Enoxacin; Humans; Male; Ofloxacin; Oxidation-Reduction; Theophylline; Uric Acid; Xanthines	1989
Inhibitory effect of enoxacin, ofloxacin and norfloxacin on renal excretion of theophylline in humans. European journal of clinical pharmacology, 1989, Volume: 36, Issue:3 Topics: Adult; Drug Interactions; Enoxacin; Female; Humans; Kidney; Male; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Theophylline	1989
Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptor. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:11 Topics: Animals; Ciprofloxacin; Diclofenac; Drug Synergism; GABA Antagonists; In Vitro Techniques; Male; Muscimol; Nalidixic Acid; Ofloxacin; Quinolones; Rats; Rats, Inbred Strains; Receptors, GABA-A; Theophylline	1988
Effect of ofloxacin on the pharmacokinetics of a single intravenous theophylline dose. Therapeutic drug monitoring, 1988, Volume: 10, Issue:2 Topics: Adult; Anti-Infective Agents; Drug Interactions; Half-Life; Humans; Injections, Intravenous; Male; Ofloxacin; Oxazines; Theophylline	1988
Inhibition of the oxidative metabolism of theophylline in isolated rat hepatocytes by the quinolone antibiotic enoxacin and its metabolite oxoenoxacin, but not by ofloxacin. Biochemical pharmacology, 1988, Jul-01, Volume: 37, Issue:13 Topics: Animals; Enoxacin; In Vitro Techniques; Liver; Male; Naphthyridines; Ofloxacin; Oxazines; Oxidation-Reduction; Quinolines; Rats; Structure-Activity Relationship; Theophylline	1988
Effects of enoxacin, ofloxacin and norfloxacin on theophylline disposition in humans. European journal of clinical pharmacology, 1988, Volume: 35, Issue:2 Topics: 17-Hydroxycorticosteroids; Adult; Aminophylline; Enoxacin; Female; Humans; Hydrocortisone; Male; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Theophylline	1988
The influence of ofloxacin and enoxacin on the metabolic pathways of theophylline in healthy volunteers. A pilot study. Pharmaceutisch weekblad. Scientific edition, 1988, Dec-09, Volume: 10, Issue:6 Topics: Adult; Dealkylation; Drug Interactions; Enoxacin; Humans; Kidney; Male; Ofloxacin; Oxidation-Reduction; Theophylline	1988
Pharmacokinetics of ofloxacin and theophylline alone and in combination. Infection, 1986, Volume: 14 Suppl 1 Topics: Adolescent; Adult; Anti-Infective Agents; Drug Interactions; Humans; Kinetics; Male; Ofloxacin; Oxazines; Theophylline	1986
Inhibition of theophylline clearance by coadministered ofloxacin without alteration of theophylline effects. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:3 Topics: Adolescent; Adult; Anti-Infective Agents; Drug Interactions; Humans; Kinetics; Male; Metabolic Clearance Rate; Ofloxacin; Oxazines; Structure-Activity Relationship; Theophylline	1987
Comparative pharmacokinetics of theophylline following two fluoroquinolones co-administration. European journal of clinical pharmacology, 1987, Volume: 32, Issue:4 Topics: Adult; Anti-Infective Agents; Drug Interactions; Female; Humans; Kinetics; Male; Norfloxacin; Ofloxacin; Oxazines; Theophylline	1987
New synthetic quinolone antibacterial agents and serum concentration of theophylline. Chest, 1987, Volume: 92, Issue:4 Topics: Adult; Anti-Infective Agents; Chemical Phenomena; Chemistry; Ciprofloxacin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Male; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Pipemidic Acid; Theophylline	1987
Lack of effect of ofloxacin on theophylline pharmacokinetics in rats. Chemotherapy, 1987, Volume: 33, Issue:6 Topics: Animals; Anti-Infective Agents; Blood Proteins; Cimetidine; Enoxacin; Male; Microsomes, Liver; Naphthyridines; Ofloxacin; Oxazines; Oxidoreductases; Protein Binding; Rats; Theophylline	1987
Steady-state kinetics of the quinolone derivatives ofloxacin, enoxacin, ciprofloxacin and pefloxacin during maintenance treatment with theophylline. Drugs, 1987, Volume: 34 Suppl 1 Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Drug Interactions; Enoxacin; Female; Humans; Male; Middle Aged; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines; Theophylline	1987
The influence of the 4-quinolones ciprofloxacin, pefloxacin and ofloxacin on the elimination of theophylline. Pharmaceutisch weekblad. Scientific edition, 1987, Dec-11, Volume: 9 Suppl Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Female; Humans; Lung Diseases, Obstructive; Male; Metabolic Clearance Rate; Middle Aged; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines; Theophylline	1987
Effect of levofloxacin on theophylline clearance during theophylline and clarithromycin combination therapy. The Annals of pharmacotherapy, 2001, Volume: 35, Issue:6 Topics: Anti-Infective Agents; Clarithromycin; Drug Interactions; Drug Therapy, Combination; Emphysema; Humans; Levofloxacin; Male; Metabolic Clearance Rate; Middle Aged; Ofloxacin; Theophylline	2001
Effect of ofloxacin on theophylline pharmacokinetics at clinical dosage in dogs. Journal of veterinary pharmacology and therapeutics, 2006, Volume: 29, Issue:5 Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Dogs; Drug Interactions; Female; Half-Life; Injections, Intravenous; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Protein Binding; Theophylline; Vasodilator Agents	2006
A physiologically based pharmacokinetic model characterizing mechanism-based inhibition of CYP1A2 for predicting theophylline/antofloxacin interaction in both rats and humans. Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:4 Topics: Animals; Area Under Curve; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Fluoroquinolones; Humans; Liver; Male; Microsomes, Liver; Models, Animal; Models, Theoretical; Ofloxacin; Phosphodiesterase Inhibitors; Rats; Theophylline	2011
Application of organogels as oral controlled release formulations of hydrophilic drugs. International journal of pharmaceutics, 2012, Oct-15, Volume: 436, Issue:1-2 Topics: Animals; Antipyrine; Delayed-Action Preparations; Drug Administration Routes; Gels; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Male; Ofloxacin; Rats; Rats, Wistar; Solubility; Soybean Oil; Stearic Acids; Suspensions; Theophylline	2012