ofloxacin and sitafloxacin

ofloxacin has been researched along with sitafloxacin in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (45.95)18.2507
2000's12 (32.43)29.6817
2010's8 (21.62)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aubry, A; Cambau, E; Jarlier, V; Matrat, S; Petrella, S; Sougakoff, W1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Hakanen, AJ; Huovinen, P; Kotilainen, P; Lehtopolku, M; Nakari, UM; Siitonen, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Bera, S; Mondal, D1
Carlyn, CJ; Doyle, LJ; Knapp, CC; Ludwig, MD; Washington, JA1
Cormican, MG; Jones, RN; Marshall, SA1
Bale, MJ; Erwin, ME; Jones, RN1
Houston, AK; Jones, RN1
Allen, SD; Erwin, ME; Gerlach, EH; Jones, RN; Marshall, SA; Murray, PR; Washington, JA1
Morrissey, I; Smith, JT2
Arai, T; Kinoshita, T; Nimura, N1
Hayakawa, I; Hohmura, M; Hoshino, K; Ishida, H; Kitamura, A; Nishino, T; Sato, K; Tanaka, M1
Hecht, DW; Wexler, HM1
Goldstein, EJ1
Morrissey, I1
Inui, KI; Ito, T; Tanaka, K; Yano, I1
Izumi, K; Kawazoe, K; Mikamo, H; Sato, Y; Tamaya, T1
Sanders, CC; Thomson, KS1
Giamarellos-Bourboulis, EJ; Giamarellou, H; Grecka, P; Sambatakou, H1
Akaki, T; Kajitani, H; Kawahara, S; Sakatani, M; Sato, K; Tomioka, H1
Matsushima, T; Miyashita, N; Niki, Y1
Dhople, AM; Namba, K1
Cai, S; Kamei, T; Ogasawara, K; Sano, C; Sano, K; Sato, K; Shimizu, T; Tomioka, H1
Hoshino, K; Ishida, H; Ishida, Y; Kawato, H; Kurosaka, Y; Lee, VJ; Nakayama, K; Ohta, T; Ohtsuka, M; Otani, T; Renau, TE; Watkins, WJ; Yokomizo, Y; Yoshida, K1
Dawe, RS; Ferguson, J; Ibbotson, SH; Sanderson, JB; Thomson, EM1
Akamine, M; Fujita, J; Haranaga, S; Higa, F; Nakasone, C; Nakasone, I; Shinzato, T; Tateyama, M; Touyama, M; Yamane, N1
Izumikawa, K; Kakeya, H; Kamihira, S; Kohno, S; Morinaga, Y; Nakamura, S; Seki, M; Yamamoto, Y; Yanagihara, K1
Fujioka, T; Hasegawa, M; Ikeda, F; Kobayashi, I; Kodama, M; Murakami, K; Muraoka, H; Okimoto, T; Saika, T; Takigawa, M; Tanahashi, J1
Hori, S1
Higuchi, W; Imamura, Y; Kanda, H; Nishiyama, A; Takano, T; Taneike, I; Yamamoto, T; Yoshida, K1
Berning, M; Krasz, S; Labenz, J; Miehlke, S; Morgner, A1
Chen, X; Guo, X; Shi, G; Wang, H; Wang, S; Zhang, X1
Malithong, A; Phiboonbanakit, D; Santiwatanakul, S; Srisangchan, P; Srisurat, N; Susaengrat, W; Tantisiriwat, W; Thamlikitkul, V; Thunyaharn, S; Tiengrim, S1
Ang, TL; Song, M1

Reviews

4 review(s) available for ofloxacin and sitafloxacin

ArticleYear
Insights of synthetic analogues of anti-leprosy agents.
    Bioorganic & medicinal chemistry, 2019, 07-01, Volume: 27, Issue:13

    Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship

2019
Possible role for the new fluoroquinolones (levofloxacin, grepafloxacin, trovafloxacin, clinafloxacin, sparfloxacin, and DU-6859a) in the treatment of anaerobic infections: review of current information on efficacy and safety.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23 Suppl 1

    Topics: Anti-Infective Agents; Bacteria, Anaerobic; Bacterial Infections; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolones; Safety; Syndrome

1996
[Current value of quinolones in Helicobacter pylori therapy].
    Zeitschrift fur Gastroenterologie, 2011, Volume: 49, Issue:8

    Topics: Anti-Bacterial Agents; Aza Compounds; Drug Resistance, Bacterial; Drug Therapy, Combination; Fluoroquinolones; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Ofloxacin; Quinolines

2011
Second and third line treatment options for Helicobacter pylori eradication.
    World journal of gastroenterology, 2014, Feb-14, Volume: 20, Issue:6

    Topics: Anti-Bacterial Agents; Bismuth; Drug Resistance, Bacterial; Drug Therapy, Combination; Fluoroquinolones; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Metronidazole; Moxifloxacin; Ofloxacin; Rifabutin; Rifamycins; Rifaximin; Salvage Therapy; Virulence Factors

2014

Trials

1 trial(s) available for ofloxacin and sitafloxacin

ArticleYear
A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity.
    The British journal of dermatology, 2003, Volume: 149, Issue:6

    Topics: Adult; Anti-Bacterial Agents; Asian People; China; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Drug Administration Schedule; Enoxacin; Female; Fluoroquinolones; Follow-Up Studies; Humans; Japan; Levofloxacin; Light; Male; Middle Aged; Ofloxacin; Scotland; Single-Blind Method; Skin Tests; Statistics, Nonparametric; White People

2003

Other Studies

32 other study(ies) available for ofloxacin and sitafloxacin

ArticleYear
Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:5

    Topics: Anti-Infective Agents; DNA; DNA Gyrase; DNA, Superhelical; Enzyme Inhibitors; Mycobacterium leprae; Quinolones; Topoisomerase II Inhibitors

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Anti-Bacterial Agents; Campylobacter coli; Campylobacter Infections; Campylobacter jejuni; Carbapenems; Drug Resistance, Multiple, Bacterial; Erythromycin; Feces; Finland; Humans; Macrolides; Microbial Sensitivity Tests; Minocycline; Tigecycline

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Activities of three investigational fluoroquinolones (BAY y 3118, DU-6859a, and clinafloxacin) against Neisseria gonorrhoeae isolates with diminished susceptibilities to ciprofloxacin and ofloxacin.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:7

    Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Ofloxacin; Quinolones; Spiro Compounds

1995
Cross-resistance analysis for DU-6859a, a new fluoroquinolone, compared to six structurally similar compounds (ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin).
    Diagnostic microbiology and infectious disease, 1995, Volume: 21, Issue:1

    Topics: Anti-Infective Agents; Bacteria, Aerobic; Ciprofloxacin; Drug Resistance, Microbial; Drug Resistance, Multiple; Fleroxacin; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Ofloxacin; Quinolones; Spiro Compounds

1995
Minimum inhibitory concentration quality-control guidelines for biapenem, DU-6859a, FK-037, levofloxacin, grepafloxacin, and ceftizoxime when using various National Committee for Clinical Laboratory Standards susceptibility test methods. Quality Control S
    Diagnostic microbiology and infectious disease, 1994, Volume: 19, Issue:1

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Ceftizoxime; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Ofloxacin; Piperazines; Quality Control; Quinolones; Reference Values; Spiro Compounds; Thienamycins

1994
Postantibiotic effect of DU-6859a and levofloxacin as compared with ofloxacin.
    Diagnostic microbiology and infectious disease, 1994, Volume: 18, Issue:1

    Topics: Anti-Infective Agents; Bacteria; Enterococcus faecalis; Escherichia coli; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Ofloxacin; Pseudomonas aeruginosa; Quinolones; Staphylococcus aureus

1994
In-vitro comparison of DU-6859a, a novel fluoroquinolone, with other quinolones and oral cephalosporins tested against 5086 recent clinical isolates.
    The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:6

    Topics: Anti-Infective Agents; Bacteria, Aerobic; Cefixime; Cefotaxime; Cefuroxime; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Ofloxacin; Quinolones

1993
Activity of new 4-quinolones in combination with erythromycin or tetracycline against S. pneumoniae.
    Drugs, 1995, Volume: 49 Suppl 2

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Drug Therapy, Combination; Erythromycin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Ofloxacin; Pneumococcal Infections; Quinolones; Spiro Compounds; Streptococcus pneumoniae; Tetracycline

1995
The new 4-quinolones DU-6859a and DV-7751a show enhanced activity against Streptococcus pneumoniae.
    Drugs, 1995, Volume: 49 Suppl 2

    Topics: Anti-Infective Agents; Culture Media; Drug Resistance, Microbial; Fluoroquinolones; Microbial Sensitivity Tests; Ofloxacin; Quinolones; Spiro Compounds; Streptococcus pneumoniae

1995
Investigation of enantioselective separation of quinolonecarboxylic acids by capillary zone electrophoresis using vancomycin as a chiral selector.
    Journal of chromatography. A, 1996, Jun-07, Volume: 736, Issue:1-2

    Topics: Anti-Infective Agents; Electrophoresis, Capillary; Fluoroquinolones; Ofloxacin; Quinolones; Stereoisomerism; Vancomycin

1996
Effect of growth conditions on antimicrobial activity of DU-6859a and its bactericidal activity determined by the killing curve method.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 37, Issue:6

    Topics: Anti-Infective Agents; Cell Division; Ciprofloxacin; Culture Media; Culture Media, Serum-Free; Drug Resistance, Microbial; Escherichia coli; Fluoroquinolones; Humans; Hydrogen-Ion Concentration; Kinetics; Levofloxacin; Metals; Microbial Sensitivity Tests; Microscopy, Electron; Ofloxacin; Pseudomonas aeruginosa; Quinolones; Staphylococcus aureus; Urine

1996
In vitro susceptibility of anaerobes to quinolones in the United States.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23 Suppl 1

    Topics: Anti-Infective Agents; Bacteria, Anaerobic; Culture Media; Drug Resistance, Microbial; Evaluation Studies as Topic; Fluoroquinolones; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Piperazines; Quinolones; United States

1996
Bactericidal index: a new way to assess quinolone bactericidal activity in vitro.
    The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:6

    Topics: Anti-Infective Agents; Ciprofloxacin; Enterococcus faecalis; Fluoroquinolones; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones

1997
Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2

    Topics: Animals; Anti-Infective Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Epithelial Cells; Epithelium; Fluoroquinolones; Humans; Kidney; Levofloxacin; LLC-PK1 Cells; Ofloxacin; Quinolones; Swine

1997
Therapeutic effects of a new quinolone, DU-6859a, on polymicrobial infections in a newly designed model of rat uterine endometritis.
    The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:1

    Topics: Animals; Anti-Infective Agents; Bacteroides fragilis; Disease Models, Animal; Drug Therapy, Combination; Endometritis; Escherichia coli; Female; Fluoroquinolones; Levofloxacin; Ofloxacin; Quinolones; Rats; Rats, Sprague-Dawley

1998
The effects of increasing levels of quinolone resistance on in-vitro activity of four quinolones.
    The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:2

    Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Mutation; Nalidixic Acid; Ofloxacin; Quinolones

1998
In vitro activity of quinupristin/dalfopristin and newer quinolones combined with gentamicin against resistant isolates of Enterococcus faecalis and Enterococcus faecium.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1998, Volume: 17, Issue:9

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Enterococcus faecalis; Enterococcus faecium; Fluoroquinolones; Gentamicins; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones; Virginiamycin

1998
Comparative in vitro antimicrobial activities of the newly synthesized quinolone HSR-903, sitafloxacin (DU-6859a), gatifloxacin (AM-1155), and levofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:12

    Topics: Anti-Infective Agents; Fluoroquinolones; Gatifloxacin; Levofloxacin; Microbial Sensitivity Tests; Mycobacterium avium Complex; Mycobacterium tuberculosis; Ofloxacin; Quinolones

1999
In vitro and in vivo activities of sitafloxacin against Chlamydia spp.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:11

    Topics: Animals; Anti-Infective Agents; Chlamydia; Chlamydia Infections; Fluoroquinolones; Humans; Mice; Microbial Sensitivity Tests; Ofloxacin

2001
In vivo susceptibility of Mycobacterium leprae to sitafloxacin (DU-6859a), either singly or in combination with rifampicin analogues.
    International journal of antimicrobial agents, 2003, Volume: 21, Issue:3

    Topics: Animals; Drug Resistance, Bacterial; Drug Therapy, Combination; Female; Fluoroquinolones; Leprostatic Agents; Leprosy; Mice; Mice, Inbred BALB C; Mycobacterium leprae; Ofloxacin; Rifampin

2003
Comparative antimicrobial activities of gatifloxacin, sitafloxacin and levofloxacin against Mycobacterium tuberculosis replicating within Mono Mac 6 human macrophage and A-549 type II alveolar cell lines.
    The Journal of antimicrobial chemotherapy, 2003, Volume: 52, Issue:2

    Topics: Anti-Infective Agents; Antibiotics, Antitubercular; Cell Line; Epithelial Cells; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Macrophages; Mycobacterium tuberculosis; Ofloxacin; Pulmonary Alveoli

2003
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds.
    Bioorganic & medicinal chemistry letters, 2003, Dec-01, Volume: 13, Issue:23

    Topics: Animals; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Biological Transport, Active; Carrier Proteins; Drug Resistance, Microbial; Fluoroquinolones; Gene Expression Regulation, Bacterial; Lactams; Levofloxacin; Membrane Transport Proteins; Mice; Microbial Sensitivity Tests; Neutropenia; Ofloxacin; Protein Binding; Pseudomonas aeruginosa; Rats; Sepsis; Serum Albumin; Structure-Activity Relationship

2003
In vitro activity of sitafloxacin against clinical strains of Streptococcus pneumoniae with defined amino acid substitutions in QRDRs of gyrase A and topoisomerase IV.
    The Journal of antimicrobial chemotherapy, 2006, Volume: 58, Issue:6

    Topics: Amino Acid Substitution; Anti-Bacterial Agents; Bacterial Proteins; DNA Gyrase; DNA Topoisomerase IV; DNA, Bacterial; Drug Resistance, Bacterial; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Ofloxacin; Sequence Analysis, DNA; Streptococcus pneumoniae

2006
Comparative mutant prevention concentration and mutant selection window of sitafloxacin versus other quinolones using strains of Haemophilus influenzae with decreasing susceptibility to levofloxacin.
    International journal of antimicrobial agents, 2009, Volume: 33, Issue:5

    Topics: Adaptation, Biological; Anti-Bacterial Agents; Drug Resistance, Bacterial; Fluoroquinolones; Haemophilus influenzae; Humans; Levofloxacin; Mutation; Ofloxacin; Quinolones; Selection, Genetic

2009
Sitafloxacin activity against Helicobacter pylori isolates, including those with gyrA mutations.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7

    Topics: Anti-Bacterial Agents; DNA Gyrase; Fluoroquinolones; Helicobacter pylori; Levofloxacin; Microbial Sensitivity Tests; Mutation; Ofloxacin

2009
Convulsant activity of sitafloxacin and its interactions with anti-inflammatory drugs in mice.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2009, Volume: 15, Issue:4

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Interactions; Fluoroquinolones; Injections, Intraventricular; Levofloxacin; Mice; Ofloxacin; Seizures

2009
Helicobacter pylori eradication by sitafloxacin-lansoprazole combination and sitafloxacin pharmacokinetics in Mongolian gerbils and its in vitro activity and resistance development.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:9

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Bacterial Agents; Drug Combinations; Fluoroquinolones; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Lansoprazole; Levofloxacin; Male; Microbial Sensitivity Tests; Ofloxacin

2011
Activity of sitafloxacin against extracellular and intracellular Staphylococcus aureus in vitro and in vivo: comparison with levofloxacin and moxifloxacin.
    The Journal of antibiotics, 2012, Volume: 65, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Aza Compounds; Cell Line; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Space; Fluoroquinolones; Intracellular Space; Levofloxacin; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Moxifloxacin; Ofloxacin; Peritonitis; Quinolines; Staphylococcal Infections; Staphylococcus aureus; Time Factors

2012
Comparative in vitro activity of sitafloxacin against bacteria isolated from Thai patients with urinary tract infections and lower respiratory tract infections.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2012, Volume: 95 Suppl 2

    Topics: Anti-Bacterial Agents; Aza Compounds; Bacteria; Ciprofloxacin; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Ofloxacin; Quinolines; Respiratory Tract Infections; Thailand; Urinary Tract Infections

2012