ofloxacin has been researched along with enoxacin in 179 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 85 (47.49) | 18.7374 |
| 1990's | 42 (23.46) | 18.2507 |
| 2000's | 29 (16.20) | 29.6817 |
| 2010's | 19 (10.61) | 24.3611 |
| 2020's | 4 (2.23) | 2.80 |
| Authors | Studies |
|---|---|
| Inoue, Y; Kondo, H; Sakamoto, F; Taguchi, M; Tsukamoto, G | 1 |
| Domagala, JM; Hanna, LD; Heifetz, CL; Hutt, MP; Mich, TF; Sanchez, JP; Solomon, M | 1 |
| Domagala, JM; Heifetz, CL; Mich, TF; Nichols, JB | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Antón-Fos, GM; Duart, MJ; Mut-Ronda, S; Salabert-Salvador, MT | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Aubry, A; Cambau, E; Jarlier, V; Matrat, S; Mayer, C | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Long, F; Rouquette-Loughlin, C; Shafer, WM; Yu, EW | 1 |
| Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M | 1 |
| Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI | 1 |
| Hashida, Y; Konaka, R; Kourai, H; Maseda, H; Shirai, A | 1 |
| Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Avdeef, A; Sun, N; Tam, KY; Tsinman, O | 1 |
| Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Brea, J; Cadavid, MI; Campillo, NE; Ceballos, P; Gil, C; Loza, MI; Martínez, A; Moro, MA; Pérez, C; Pérez, DI; Perez-Castillo, A; Redondo, M; Val, C; Zarruk, JG | 1 |
| Andrisano, V; Bolognesi, ML; Carloni, P; Cavalli, A; Chiriano, G; De Simone, A; Legname, G; Mancini, F; Martinez, A; Perez, DI; Roberti, M | 1 |
| Alonso-Gil, S; Campillo, NE; Castro, A; Encinas, A; Gil, C; Martinez, A; Morales-Garcia, JA; Palomo, V; Perez, C; Perez, DI; Perez-Castillo, A; Soteras, I | 1 |
| Alonso-Gil, S; Chavarría, C; Gil, C; Morales Garcia, JA; Pérez, C; Perez, DI; Pérez-Castillo, A; Porcal, W; Souza, JM | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bello, ML; Gil, C; Kraemer, BC; Lecourtois, M; Liachko, NF; Martinez, A; Miguel, L; Perez, C; Perez, DI; Redondo, M; Salado, IG | 1 |
| Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Campillo, NE; Geiger, L; Gil, C; González, S; Li, L; Martinez, A; Morales, AV; Perez, DI; Salado, IG; Sebastián-Pérez, V; Zaldivar-Diez, J | 1 |
| Dong, SN; Gong, Q; Li, J; Li, XK; Liu, WW; Mao, F; Tang, Y; Wang, H; Wang, TD; Xu, YX; Zhang, HY; Zhu, J | 1 |
| Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V | 1 |
| Blaskovich, MAT; Pham, TDM; Ziora, ZM | 1 |
| Balliano, TL; Barbosa, G; Carvalho, VF; da Silva, BA; de Souza, ET; Lima, LM; Martins, IRR; Martins, MA; Medeiros, MM; Moraes Junior, MO; Nunes, IKDC; Silva, PMR; Silva, SWD | 1 |
| Chen, H; Ding, H; Gao, Y; Jiang, X; Liu, W; Liu, X; Tian, L; Xu, Z; Zhao, Q | 1 |
| Chaikuad, A; de Lago, E; Gil, C; Gomez-Almeria, M; Gonzalo-Consuegra, C; Knapp, S; Lietha, D; Martín-Requero, A; Martinez, A; Martínez-González, L; Monti, B; Nozal, V; Palomo, V; Pérez-Cuevas, E; Petralla, S; Ramírez, D; Santana, P | 1 |
| Arai, S; Gohara, Y; Kawashima, T; Kuwano, K; Matsu-Ura, I | 1 |
| Jones, RN | 1 |
| Kiyota, H; Mitani, H | 1 |
| Erwin, ME; Jones, RN | 1 |
| Allen, SD; Baker, CN; Barry, AL; Fuchs, PC; Hardy, DJ; Jorgensen, JH; McLaughlin, JC | 1 |
| Barbé, J; Clerch, B; Llagostera, M | 1 |
| Chidiac, C; Mouton, Y; Senneville, E | 1 |
| Liu, YN; Sun, XD; Wang, R; Zhao, HZ | 1 |
| Hoshino, K; Saiki, A; Sawai, T; Yamaguchi, A | 1 |
| Cherubin, CE; Eng, RH; Smith, SM; Tan, EN | 1 |
| Kudo, M; Ohkubo, T; Sugawara, K | 1 |
| Takayama, S; Wagai, N; Yoshida, M | 1 |
| Bethune, L; King, A; Phillips, I | 1 |
| Barry, AL; Fuchs, PC | 2 |
| Kimura, K; Kise, M; Kitano, M; Matsuda, M; Nishino, T; Otsuki, M; Ozaki, M; Segawa, J; Shibata, K; Tomii, Y | 1 |
| Byl, B; Jacobs, F; Thys, JP | 1 |
| Mnatsakanian, VE; Padeĭskaia, EN | 1 |
| Furusawa, M; Iino, T; Marumoto, Y; Nozaki-Renard, J; Ohta, G; Sato, Y | 1 |
| Allen, RA; Amyes, SG; Lewin, CS | 1 |
| Boeckk, M; Borner, K; Deppermann, N; Höffken, G; Koeppe, P; Lode, H | 1 |
| Borsa-Lebas, F; Dhib, M; Fillastre, JP; Humbert, G; Leroy, A; Moulin, B | 1 |
| Barnett, G; Carbó, M; de la Torre, R; Segura, J | 1 |
| Hayashi, Y; Ito, G; Kato, M; Takeuchi, T; Tashiro, T; Yamada, Y; Yamamoto, K; Yoshitomo, K | 1 |
| Nakanishi, S; Okuno, H | 1 |
| Matsumoto, F; Morita, M; Takahashi, T | 1 |
| Daschner, F; Kropec, A | 1 |
| Aubert, G; Denis, M; Dorche, G; Loboguerrero, M; Lucht, F; Puech, C | 1 |
| Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, GJ | 1 |
| Fong, IW | 1 |
| Dopp, C; Naumann, P | 1 |
| Goto, M; Kawakatsu, K; Sano, M; Takeyama, M; Yamamoto, I; Yamashina, H | 1 |
| Kashimoto, S; Kojima, T; Kouno, K; Kurobe, N; Minami, A; Nakamura, S; Nakata, K; Ohue, T; Sakaguchi, Y; Yoshida, H | 1 |
| Shah, PM | 2 |
| Harder, S; Papenburg, A; Staib, AH; Stille, W | 1 |
| Bia, FJ; Divo, AA; Patton, CL; Sartorelli, AC | 1 |
| Beer, C; Harder, S; Papenburg, A; Shah, PM; Staib, AH; Stille, W | 1 |
| Neu, HC | 3 |
| Appleman, ME; Gaines, JK; Hadfield, TL; Winn, RE | 1 |
| Hooper, DC; Wolfson, JS | 1 |
| Klesel, N; Limbert, M; Schrinner, E; Seibert, G; Winkler, I | 1 |
| Baur, C; Davies, BI; Maesen, FP; Teengs, JP | 2 |
| Edlund, C; Nord, CE | 2 |
| Bailey, J; Heppleston, C; Richmond, SJ | 1 |
| Auckenthaler, R; Michéa-Hamzehpour, M; Pechère, JC | 1 |
| Smith, SM | 1 |
| Avesani, V; Delmee, M | 1 |
| Kemmerich, B; Pennington, JE; Small, GJ | 1 |
| Felmingham, D; Grüneberg, RN; O'Hare, MD; Ridgway, GL | 2 |
| Cremer, AW; Felmingham, D; Grüneberg, RN; O'Hare, MD; Ridgway, GL; Robbins, MJ; Wall, RA; Williams, AH | 1 |
| Baltch, AL; Bassey, CM; Smith, RP | 1 |
| Barry, AL; Jones, RN; Thornsberry, C | 1 |
| Grimm, H | 2 |
| Høiby, N | 1 |
| Just, G; Shah, PM; Stille, W; Weigand, G | 1 |
| Beer, C; Harder, S; Mieke, S; Shah, P; Staib, AH; Stille, W | 1 |
| Cohen, SP; Hooper, DC; Levy, SB; McMurry, LM; Souza, KS; Wolfson, JS | 1 |
| Mitsui, K; Miyake, Y; Suginaka, H | 1 |
| Davies, S; Sparham, PD; Spencer, RC | 1 |
| Berlin, OG; Bruckner, DA; Young, LS | 1 |
| Kudoh, Y; Matsushita, S; Ohashi, M; Yamada, S | 1 |
| Habiyaremye, I; Vandepitte, J; Verbist, L | 1 |
| Verbist, L | 1 |
| Cancet, B; Clave, D; Didier, J; Henry-Ferry, S; Marty, N | 1 |
| Bebear, C; de Barbeyrac, B; Quentin, C; Renaudin, H | 1 |
| Kresken, M; Wiedemann, B | 1 |
| Fernandes, PB; Swanson, RN | 1 |
| Baars, B; Cullmann, W; Opferkuch, W; Stieglitz, M | 1 |
| King, A; Phillips, I; Shannon, K | 1 |
| Bailey, J; Heppleston, C; Richmond, S | 1 |
| Bryskier, A; Devos, J; Dubreuil, L; Romond, C | 1 |
| Mulder, GJ; Nagelkerke, JF; Tijdens, RB; Van der Mark, EJ; Wijnands, WJ | 1 |
| Kurata, T; Okazaki, O; Tachizawa, H | 1 |
| Chin, NX; Neu, HC; Novelli, A | 1 |
| Citron, DM; Goldstein, EJ | 1 |
| Goto, M; Kawakatsu, K; Ohkita, C; Sano, M; Takeyama, M; Yamamoto, I; Yamashina, H | 1 |
| Asakawa, M; Yasumoto, R | 1 |
| De Witte, TM; Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, WJ | 1 |
| Cattier, B; Gavignet, M; Goudeau, A; Koubaa, N; Quentin, R | 1 |
| Walker, RC; Wright, AJ | 1 |
| Andrews, JM; Griggs, D; Lister, D; McNulty, CA; Wise, R | 2 |
| Rietbrock, N; Staib, AH | 1 |
| Dabbs, DJ; Limb, DI; Spencer, RC | 1 |
| Ayers, LW; Barry, AL; Fuchs, PC; Gavan, TL; Gerlach, EH; Jones, RN; Thornsberry, C | 1 |
| Arpi, M; Bentzon, MW; Gahrn-Hansen, B; Søgaard, P | 1 |
| Barry, AL; Jones, RN | 1 |
| Smith, CR | 1 |
| Miyazaki, K; Okazaki, O; Tachizawa, H | 1 |
| Beer, C; Frech, K; Harder, S; Mieke, S; Shah, PM; Staib, AH; Stille, W | 1 |
| Baars, AM; van Herwaarden, CL; Vree, TB; Wijnands, WJ | 1 |
| Beer, C; Dietlein, G; Harder, S; Mieke, S; Shah, PM; Staib, AH; Stille, W | 1 |
| Borner, K; Glatzel, P; Höffken, G; Koeppe, P; Lode, H; Olschewski, P; Prinzing, C; Reimnitz, D; Sievers, B; Wiley, R | 1 |
| Akalin, E; Baykal, M | 1 |
| Borner, K; Kemmerich, B; Pennington, JE | 1 |
| Davies, BI; Maesen, FP | 1 |
| Weisser, J; Wiedemann, B | 1 |
| Smith, JT | 1 |
| Eggleston, M; Park, SY | 1 |
| Kumada, T; Neu, HC | 1 |
| Bauernfeind, A; Ullmann, U | 1 |
| Arman, D; Tural, D; Willke, A | 1 |
| Fujita, H; Matsuo, I | 1 |
| Cho, JK; Han, HJ; Kim, JH; Kim, K; Lee, DS; Park, WB | 1 |
| Iakovlev, VP | 1 |
| Griffiths, NM; Hirst, BH; Simmons, NL | 1 |
| Aoki, H; Fujisawa, C; Hakusui, H; Kurata, T; Ohshima, Y; Okazaki, O; Tanaka, M | 1 |
| Mitsuhashi, S; Yoshida, T | 1 |
| Li, H; Liu, S; Xu, G | 1 |
| Hale, JA; Knapp, JS; Neal, SW; Rice, RJ; Whittington, WL; Wintersheid, K | 1 |
| Cheung, MM; Ho, NK; Kam, KM; Wong, PW | 1 |
| Arakane, K; Hirobe, M; Mashiko, S; Nagano, T; Ryu, A; Umezawa, N | 1 |
| Fujimura, H; Kohno, K; Niwa, M; Nozaki, M; Uematsu, T | 1 |
| Barbosa, J; Bergés, R; Sanz-Nebot, V | 1 |
| Albini, A; Fasani, E; Profumo, A | 1 |
| Aoyagi, K; Fujishima, M; Iida, M; Kimura, Y; Koga, H; Yoshimura, R | 1 |
| Ahr, HJ; Blotz, A; Blümel, J; Dubertret, L; Michel, L; Moysan, A; Vohr, HW | 1 |
| Clark, DW; Layton, D; Pearce, GL; Shakir, SA; Wilton, LV | 1 |
| Schaeffer, AJ | 1 |
| Hayakawa, H; Kawamura, Y; Miyazaki, M; Nagasawa, M; Nakamura, S; Nojima, Y | 1 |
| Ono, C; Tanaka, M | 1 |
| Dawe, RS; Ferguson, J; Ibbotson, SH; Sanderson, JB; Thomson, EM | 1 |
| Inoue, K; Kumakura, S; Tsutsui, T; Uchida, M | 1 |
| Hong, JW; Hu, CQ; Sheng, LS | 1 |
| Chiang, CH; Lu, DW; Tai, MC | 1 |
| Hatano, K | 1 |
| Holzgrabe, U; Kiefer, W; Neugebauer, U; Popp, J; Schmitt, M; Szeghalmi, A | 1 |
| Espinosa-Mansilla, A; Gómez, DG; Peña, AM; Salinas, F | 1 |
| Chen, SL; Ding, F; Liu, Y; Zhao, HC | 1 |
| Azadian, BS; Roberts, AP; Talboys, CA | 1 |
| Depta, JP; Pichler, WJ; Schmid, DA | 1 |
| Guo, H; Li, J; Liu, Z; Nie, S; Pan, W | 1 |
| Romero, IC; Saravia, NG; Walker, J | 1 |
| Fan, Y; Gan, X; Li, S; Qin, W | 1 |
| Chen, X; Hua, H; Ji, C; Lin, X; Liu, Y; Tang, S; Yue, Z | 1 |
| Kim, J; Ohtani, H; Sawada, Y; Tsujimoto, M | 1 |
| Liu, YM; Liu, ZL; Shi, YM | 1 |
| Aubry, A; Chauffour, A; Farinotti, R; Fernandez, C; Jarlier, V; Lott, MC; Poissy, J; Veziris, N | 1 |
| Alañón Molina, A; Boras, N; Murillo Pulgarín, JA | 1 |
| Kodawara, T; Masada, M; Masuda, S; Matsubara, K; Nakamura, T; Yano, Y | 1 |
| Ahmad, I; Akhtar, T; Ambreen, A; Gandapor, AJ; Khan, A; Khan, AM; Ullah, O | 1 |
| Growkova, K; Mlcochova, J; Radova, L; Slaby, O; Stetkova, M; Uldrijan, S; Valcikova, B; Valianatos, G; Verlande, A; Vyhnakova, M | 1 |
| Chang, C; Chen, T; Li, J; Liu, F; Lu, X; Niwa, O; Wang, Q; Xue, Q; Zhou, T | 1 |
12 review(s) available for ofloxacin and enoxacin
| Article | Year |
|---|---|
Quinolone antibiotics.
Topics: | 2019 |
[Value of quinolones in the treatment of lower respiratory tract infections caused by intracellular organisms, excluding mycobacteria].
Topics: Anti-Infective Agents; Chlamydia Infections; Ciprofloxacin; Enoxacin; Erythromycin; Humans; In Vitro Techniques; Legionnaires' Disease; Ofloxacin; Pefloxacin; Pneumonia, Mycoplasma | 1992 |
Role of quinolones in the treatment of bronchopulmonary infections, particularly pneumococcal and community-acquired pneumonia.
Topics: Anti-Infective Agents; Bronchitis; Ciprofloxacin; Drug Therapy, Combination; Enoxacin; Humans; Ofloxacin; Pefloxacin; Pneumonia; Pneumonia, Pneumococcal | 1991 |
Pharmacokinetics of quinolones in renal insufficiency.
Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Fleroxacin; Fluoroquinolones; Glomerular Filtration Rate; Half-Life; Humans; Kidney Failure, Chronic; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Pefloxacin; Quinolones | 1990 |
The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans.
Topics: Anti-Bacterial Agents; Bacteria; Blood Proteins; Ciprofloxacin; Enoxacin; Fluorine; Humans; Kidney; Kinetics; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Protein Binding; Quinolines; Urinary Tract Infections | 1985 |
A review on the impact of 4-quinolones on the normal oropharyngeal and intestinal human microflora.
Topics: Ciprofloxacin; Enoxacin; Humans; Intestines; Naphthyridines; Norfloxacin; Ofloxacin; Oropharynx; Oxazines; Pefloxacin; Quinolines | 1988 |
Symposium on antimicrobial agents. The quinolones.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bacterial Infections; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Female; Humans; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Quinolines | 1987 |
Quinolones.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Ciprofloxacin; Enoxacin; Humans; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1987 |
New antibiotics: areas of appropriate use.
Topics: Anti-Bacterial Agents; Aztreonam; Bacterial Infections; beta-Lactamase Inhibitors; Cephalosporins; Ciprofloxacin; Enoxacin; Humans; Imipenem; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Thienamycins | 1987 |
Review of the 4-quinolones.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Ciprofloxacin; Drug Interactions; Drug Resistance, Microbial; Enoxacin; Humans; Kinetics; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Quinolines | 1987 |
[Pharmacokinetics of fluoroquinolones].
Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Humans; Norfloxacin; Ofloxacin; Pefloxacin | 1993 |
The expanding role of fluoroquinolones.
Topics: Anti-Infective Agents; Anti-Infective Agents, Urinary; Ciprofloxacin; Enoxacin; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Norfloxacin; Ofloxacin; Quinolones; Urinary Tract Infections | 2002 |
6 trial(s) available for ofloxacin and enoxacin
| Article | Year |
|---|---|
Comparison of serum bactericidal activity of 4 fluoroquinolones in healthy volunteers.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Enoxacin; Female; Fluoroquinolones; Gram-Positive Cocci; Humans; Male; Microbial Sensitivity Tests; Ofloxacin; Quinolones; Serum Bactericidal Test | 1992 |
Role of quinolones in the treatment of bronchopulmonary infections, particularly pneumococcal and community-acquired pneumonia.
Topics: Anti-Infective Agents; Bronchitis; Ciprofloxacin; Drug Therapy, Combination; Enoxacin; Humans; Ofloxacin; Pefloxacin; Pneumonia; Pneumonia, Pneumococcal | 1991 |
The role of fluoroquinolones in the management of skin, soft tissue, and bone infections.
Topics: Anti-Infective Agents; Bacterial Infections; Ciprofloxacin; Clinical Trials as Topic; Dermatitis; Enoxacin; Gram-Negative Bacteria; Humans; Ofloxacin; Osteomyelitis; Pefloxacin | 1989 |
4-quinolones inhibit biotransformation of caffeine.
Topics: Adult; Biotransformation; Caffeine; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Interactions; Enoxacin; Humans; Male; Molecular Structure; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones; Random Allocation; Theophylline | 1988 |
Interaction between quinolones and caffeine.
Topics: Adult; Anti-Infective Agents; Caffeine; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Male; Middle Aged; Naphthyridines; Ofloxacin; Oxazines; Quinolines | 1987 |
A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity.
Topics: Adult; Anti-Bacterial Agents; Asian People; China; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Drug Administration Schedule; Enoxacin; Female; Fluoroquinolones; Follow-Up Studies; Humans; Japan; Levofloxacin; Light; Male; Middle Aged; Ofloxacin; Scotland; Single-Blind Method; Skin Tests; Statistics, Nonparametric; White People | 2003 |
162 other study(ies) available for ofloxacin and enoxacin
| Article | Year |
|---|---|
Synthesis and antibacterial activity of thiazolo-, oxazolo-, and imidazolo[3,2-a][1,8]naphthyridinecarboxylic acids.
Topics: Anti-Bacterial Agents; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Imidazoles; Indicators and Reagents; Microbial Sensitivity Tests; Molecular Structure; Naphthyridines; Oxazoles; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors | 1990 |
New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay.
Topics: Anti-Bacterial Agents; Bacteria; DNA, Bacterial; DNA, Superhelical; Escherichia coli; Microbial Sensitivity Tests; Naphthyridines; Plasmids; Quinolines; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1986 |
1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity.
Topics: Animals; Anti-Bacterial Agents; Gram-Positive Bacteria; Mice; Microbial Sensitivity Tests; Naphthyridines; Quinolines; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1986 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Search compounds with antimicrobial activity by applying molecular topology to selected quinolones.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Discriminant Analysis; Drug Design; Microbial Sensitivity Tests; Quantitative Structure-Activity Relationship; Quinolones | 2003 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Mutagenesis in the alpha3alpha4 GyrA helix and in the Toprim domain of GyrB refines the contribution of Mycobacterium tuberculosis DNA gyrase to intrinsic resistance to quinolones.
Topics: Amino Acid Sequence; Antitubercular Agents; DNA Gyrase; Drug Resistance, Bacterial; Molecular Sequence Data; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Protein Structure, Secondary; Quinolones; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli.
Topics: Anti-Bacterial Agents; Antiporters; ATP-Binding Cassette Transporters; Bacterial Proteins; Cloning, Molecular; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Ethidium; Fluorescence Polarization; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Norfloxacin | 2008 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine | 2009 |
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine | 2009 |
Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Cetylpyridinium; Disinfectants; Drug Resistance, Multiple, Bacterial; Membrane Proteins; Mutation; Norfloxacin; Quaternary Ammonium Compounds; Serratia marcescens | 2009 |
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding | 2009 |
The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.
Topics: Caco-2 Cells; Cell Membrane Permeability; Humans; Hydrogen-Ion Concentration; Membranes, Artificial; Molecular Structure; Pharmaceutical Preparations | 2010 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Permeability; Quinazolines; Stroke | 2012 |
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cell Survival; Chickens; Humans; Imidazoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Neurons; Small Molecule Libraries; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship | 2012 |
5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Blood-Brain Barrier; Cell Death; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Glycogen Synthase Kinase 3; Hippocampus; Humans; Imines; In Vitro Techniques; Lipopolysaccharides; Membranes, Artificial; Microglia; Models, Molecular; Neural Stem Cells; Neurogenesis; Neurons; Neuroprotective Agents; Nitrites; Protein Binding; Rats; Structure-Activity Relationship; Substrate Specificity; Swine; Thiadiazoles | 2012 |
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.
Topics: Anti-Inflammatory Agents; Antioxidants; Blood-Brain Barrier; Cell Survival; Dose-Response Relationship, Drug; Humans; Microwaves; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxidopamine; Peroxynitrous Acid; Structure-Activity Relationship; Tyrosine | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain Barrier; Casein Kinase I; Cell Membrane Permeability; Cells, Cultured; DNA-Binding Proteins; Drosophila; Drug Design; Drug Discovery; HEK293 Cells; Heterocyclic Compounds; High-Throughput Screening Assays; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neurons; Neurotoxicity Syndromes; Phosphorylation; Protein Kinase Inhibitors; Substrate Specificity | 2014 |
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques | 2017 |
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents.
Topics: Animals; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Indoles; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Neural Stem Cells; Neuroprotective Agents; Protein Kinase Inhibitors; Structure-Activity Relationship | 2017 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Discovery; Humans; Imidazoles; Mice; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Pyrimidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea | 2018 |
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship | 2018 |
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
Topics: Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Enzyme Inhibitors; Humans; Hydrazones; Hypersensitivity; Lung; Male; Mice | 2020 |
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Dyrk Kinases; Glycogen Synthase Kinase 3 beta; Harmine; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship | 2021 |
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Case-Control Studies; DNA-Binding Proteins; Humans; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Spinal Cord; Tissue Distribution | 2022 |
[In vitro antimicrobial activities of new quinolone antibiotics against Mycoplasma pneumoniae].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Macrolides; Mycoplasma pneumoniae; Norfloxacin; Ofloxacin; Quinolones; Tetracyclines | 1992 |
In vitro evaluation of E-4695, a new fluoro-naphthyridine.
Topics: Anti-Bacterial Agents; Azetidines; Bacteria; Ciprofloxacin; Drug Evaluation, Preclinical; Enoxacin; Fleroxacin; Fluoroquinolones; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Quinolones | 1992 |
[Influence of new quinolones on superoxide anion generation of polymorphonuclear leukocytes].
Topics: Ciprofloxacin; Enoxacin; Humans; In Vitro Techniques; Neutrophils; Norfloxacin; Ofloxacin; Superoxides | 1992 |
In vitro activity of CP-74667 compared with four other fluoroquinolones.
Topics: Anti-Infective Agents; Ciprofloxacin; Drug Evaluation, Preclinical; Enoxacin; Enterobacteriaceae; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Cocci; Humans; Microbial Sensitivity Tests; Norfloxacin; Ofloxacin; Quinolones | 1992 |
Interpretive criteria and quality control parameters for testing susceptibility of Haemophilus influenzae to enoxacin, ofloxacin, and temafloxacin.
Topics: Anti-Infective Agents; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Mutation; Ofloxacin; Quality Control; Quinolones | 1992 |
The role of the excision and error-prone repair systems in mutagenesis by fluorinated quinolones in Salmonella typhimurium.
Topics: Ciprofloxacin; DNA Repair; Dose-Response Relationship, Drug; Enoxacin; Genes, Bacterial; Genotype; Mutagenesis; Mutagenicity Tests; Mutagens; Ofloxacin; Salmonella typhimurium | 1992 |
OmpF channel permeability of quinolones and their comparison with beta-lactams.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Outer Membrane Proteins; Cell Membrane Permeability; Cephalosporins; Diffusion; Enoxacin; Escherichia coli; Liposomes; Nalidixic Acid; Norfloxacin; Ofloxacin; Stereoisomerism | 1992 |
A comparison of antimicrobial activity of ofloxacin, L-ofloxacin, and other oral agents for respiratory pathogens.
Topics: Administration, Oral; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Cefuroxime; Ciprofloxacin; Clavulanic Acids; Drug Therapy, Combination; Enoxacin; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Molecular Conformation; Ofloxacin; Respiratory System; Respiratory Tract Infections; Sputum | 1992 |
Determination of ofloxacin in human serum by high-performance liquid chromatography with column switching.
Topics: Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Humans; Hydrogen-Ion Concentration; Norfloxacin; Ofloxacin; Spectrophotometry, Ultraviolet | 1992 |
Phototoxic potential of the new quinolone antibacterial agent levofloxacin in mice.
Topics: Animals; Anti-Infective Agents; Enoxacin; Female; Levofloxacin; Light; Mice; Mice, Inbred BALB C; Ofloxacin; Photosensitivity Disorders | 1992 |
The in-vitro activity of temafloxacin compared with other antimicrobial agents.
Topics: Anti-Infective Agents; Bacteria; Ciprofloxacin; Enoxacin; Enterobacteriaceae; Fluoroquinolones; Microbial Sensitivity Tests; Ofloxacin; Quinolones; Species Specificity | 1991 |
Anti-staphylococcal activity of temafloxacin, ciprofloxacin, ofloxacin and enoxacin.
Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Ofloxacin; Oxacillin; Penicillin Resistance; Quinolones; Staphylococcal Infections; Staphylococcus | 1991 |
Cross-resistance and cross-susceptibility between fluoroquinolone agents.
Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Enterobacteriaceae; Fleroxacin; Fluoroquinolones; Microbial Sensitivity Tests; Ofloxacin; Predictive Value of Tests; Quinolones | 1991 |
In vivo evaluation of NM441, a new thiazeto-quinoline derivative.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Ciprofloxacin; Dioxolanes; Dogs; Drug Evaluation, Preclinical; Enoxacin; Female; Fluoroquinolones; Male; Mice; Microbial Sensitivity Tests; Ofloxacin; Piperazines; Prodrugs; Quinolones; Respiratory Tract Infections; Streptococcal Infections; Urinary Tract Infections | 1991 |
[Activity of fluoroquinolones studied on a model of suppurative meningoencephalitis caused by Pseudomonas aeruginosa in mice].
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Disease Models, Animal; Drug Resistance, Microbial; Enoxacin; Meningoencephalitis; Mice; Ofloxacin; Pefloxacin; Pseudomonas aeruginosa; Pseudomonas Infections | 1991 |
Fluoroquinolones protect the human lymphocyte CEM cell line from HIV-1-mediated cytotoxicity.
Topics: Acquired Immunodeficiency Syndrome; Cell Line; Cell Survival; Ciprofloxacin; Enoxacin; HIV-1; Humans; Lymphocytes; Norfloxacin; Ofloxacin | 1990 |
Antibacterial activity of fluoroquinolones in combination with zidovudine.
Topics: Anti-Infective Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Enoxacin; Enterobacteriaceae; Escherichia coli; Fluoroquinolones; Microbial Sensitivity Tests; Ofloxacin; Pseudomonas aeruginosa; Quinolones; Salmonella; Staphylococcus; Zidovudine | 1990 |
Quinolone pharmacokinetics and metabolism.
Topics: Administration, Oral; Anti-Infective Agents; Biological Availability; Biotransformation; Ciprofloxacin; Enoxacin; Fleroxacin; Half-Life; Humans; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Pefloxacin | 1990 |
Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition.
Topics: Caffeine; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Male; Models, Biological; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones | 1990 |
[The penetration of ofloxacin and enoxacin into the alveolar spaces in rats].
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Enoxacin; Ofloxacin; Pneumonia; Pulmonary Alveoli; Rats; Rats, Inbred Strains | 1990 |
Comparison of inhibitory effects of new quinolones on drug metabolizing activity in the liver.
Topics: Acetaminophen; Animals; Anti-Infective Agents; Enoxacin; Glutathione; Liver; Liver Function Tests; Male; Microsomes, Liver; Mixed Function Oxygenases; Norfloxacin; Ofloxacin; Rats; Theophylline | 1990 |
[Therapeutic drug monitoring of fluoroquinolone].
Topics: Anti-Infective Agents; Bile; Biological Assay; Biological Availability; Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Fluoroquinolones; Humans; Naphthyridines; Norfloxacin; Ofloxacin; Quinolones; Sputum | 1990 |
In vitro activity of fleroxacin and 6 other antimicrobials against Acinetobacter anitratus.
Topics: Acinetobacter; Anti-Bacterial Agents; Cefepime; Ceftazidime; Ceftriaxone; Cephalosporins; Ciprofloxacin; Enoxacin; Fleroxacin; Humans; Microbial Sensitivity Tests; Ofloxacin; Tobramycin | 1989 |
[Activity of 5 fluoroquinolones on hospital Gram-negative bacilli with different sensitivities to pefloxacin].
Topics: Anti-Infective Agents; Ciprofloxacin; Citrobacter; Drug Resistance, Microbial; Enoxacin; Escherichia coli; Fleroxacin; Gram-Negative Bacteria; Microbial Sensitivity Tests; Norfloxacin; Ofloxacin; Pefloxacin; Pseudomonas aeruginosa; Serratia marcescens | 1989 |
Drug-drug interactions affecting fluoroquinolones.
Topics: Adult; Drug Interactions; Enoxacin; Humans; Male; Ofloxacin; Oxidation-Reduction; Theophylline; Uric Acid; Xanthines | 1989 |
[Fluoroquinolones--antibacterial activity, pharmacokinetics and indications for a new group of chemotherapeutic drugs].
Topics: Adult; Anti-Infective Agents; Bacteria; Bacterial Infections; Ciprofloxacin; Dose-Response Relationship, Drug; Enoxacin; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Norfloxacin; Ofloxacin | 1989 |
Inhibitory effect of enoxacin, ofloxacin and norfloxacin on renal excretion of theophylline in humans.
Topics: Adult; Drug Interactions; Enoxacin; Female; Humans; Kidney; Male; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Theophylline | 1989 |
In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone.
Topics: Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Ciprofloxacin; Enoxacin; Fluoroquinolones; Lung Diseases; Mice; Microbial Sensitivity Tests; Norfloxacin; Ofloxacin; Skin Diseases, Infectious; Urinary Tract Infections | 1989 |
The role of quinolones in staphylococcal infection.
Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Humans; Norfloxacin; Ofloxacin; Pefloxacin; Staphylococcal Infections | 1989 |
[Gyrase inhibitors modify metabolising processes in the liver].
Topics: Caffeine; Ciprofloxacin; DNA Topoisomerases, Type II; Enoxacin; Humans; Liver; Male; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pipemidic Acid; Topoisomerase II Inhibitors | 1987 |
Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro.
Topics: Aminocoumarins; Animals; Anti-Infective Agents; Chloroquine; Ciprofloxacin; Coumarins; Drug Interactions; Drug Resistance; Enoxacin; Fluoroquinolones; Nalidixic Acid; Norfloxacin; Novobiocin; Ofloxacin; Oxolinic Acid; Pefloxacin; Plasmodium falciparum; Tetracycline; Topoisomerase II Inhibitors | 1988 |
Clinical use of the quinolones.
Topics: Anti-Infective Agents; Ciprofloxacin; Diarrhea; Enoxacin; Gastrointestinal Diseases; Humans; Naphthyridines; Norfloxacin; Ofloxacin; Osteomyelitis; Oxazines; Pefloxacin; Quinolines; Respiratory Tract Infections; Sexually Transmitted Diseases; Surgical Wound Infection; Urinary Tract Infections | 1987 |
Susceptibility of Bordetella pertussis to five quinolone antimicrobic drugs.
Topics: Anti-Bacterial Agents; Bordetella pertussis; Cinoxacin; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Humans; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Whooping Cough | 1987 |
Chemotherapeutic effects of ofloxacin (HOE 280) and other quinolone-carboxylic derivates in the treatment of experimental lung infections due to Klebsiella pneumoniae DT-S in mice.
Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Enoxacin; Klebsiella Infections; Klebsiella pneumoniae; Male; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Oxazines; Pneumonia; Quinolines | 1986 |
[New oral quinolone compounds in chronic bronchitis].
Topics: Administration, Oral; Anti-Bacterial Agents; Bacterial Infections; Bronchitis; Chronic Disease; Ciprofloxacin; Dose-Response Relationship, Drug; Enoxacin; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Male; Middle Aged; Naphthyridines; Neisseria; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Pneumococcal Infections; Pseudomonas Infections; Quinolines; Streptococcus pneumoniae | 1986 |
Comparative in vitro activities of ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin against Bacteroides fragilis and Clostridium difficile.
Topics: Anti-Bacterial Agents; Bacteroides fragilis; Ciprofloxacin; Clostridium; Enoxacin; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1986 |
The action of quinolone carboxylic acids on Chlamydia trachomatis in vitro.
Topics: Animals; Carboxylic Acids; Cells, Cultured; Chlamydia trachomatis; Ciprofloxacin; Enoxacin; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Quinolines | 1986 |
In-vitro activity of newer quinolones against aerobic bacteria.
Topics: Anti-Bacterial Agents; Bacteria, Aerobic; Calcium; Ciprofloxacin; Enoxacin; Enterobacteriaceae; Magnesium Sulfate; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Pseudomonas; Quinolines; Sulfates; Zinc; Zinc Sulfate | 1986 |
In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Enoxacin; Fluoroquinolones; Humans; Methicillin; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Penicillin Resistance; Piperazines; Quinolines; Staphylococcus aureus | 1986 |
Comparative in vitro activity of seven quinolones against 100 clinical isolates of Clostridium difficile.
Topics: Anti-Bacterial Agents; Child; Ciprofloxacin; Clostridium; Enoxacin; Fluoroquinolones; Humans; Infant, Newborn; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1986 |
Comparative evaluation of ciprofloxacin, enoxacin, and ofloxacin in experimental Pseudomonas aeruginosa pneumonia.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Enoxacin; Guinea Pigs; Kinetics; Naphthyridines; Ofloxacin; Oxazines; Pneumonia; Pseudomonas Infections; Quinolines | 1986 |
The comparative in vitro activity of twelve 4-quinolone antimicrobials against enteric pathogens.
Topics: 4-Quinolones; Aeromonas; Anti-Bacterial Agents; Anti-Infective Agents; Campylobacter fetus; Cinoxacin; Ciprofloxacin; Diarrhea; Enoxacin; Fluoroquinolones; Humans; In Vitro Techniques; Intestines; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Oxolinic Acid; Pefloxacin; Pipemidic Acid; Quinolines; Quinolizines; Quinolones; Salmonella; Shigella; Vibrio cholerae; Vibrio parahaemolyticus; Yersinia enterocolitica | 1985 |
The comparative activity of twelve 4-quinolone antimicrobials against Haemophilus influenzae and Streptococcus pneumoniae.
Topics: 4-Quinolones; Anti-Infective Agents; Cinoxacin; Ciprofloxacin; Enoxacin; Fluoroquinolones; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Oxolinic Acid; Pefloxacin; Pipemidic Acid; Quinolines; Quinolizines; Quinolones; Streptococcus pneumoniae | 1985 |
Comparative in vitro studies with 4-quinolone antimicrobials.
Topics: 4-Quinolones; Anti-Infective Agents; Bacteria; Cinoxacin; Ciprofloxacin; Enoxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Oxolinic Acid; Pefloxacin; Pipemidic Acid; Quinolines; Quinolizines; Quinolones | 1985 |
Comparative antimicrobial activity of enoxacin, ciprofloxacin, amifloxacin, norfloxacin and ofloxacin against 177 bacterial isolates.
Topics: Anti-Bacterial Agents; Bacteria; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pseudomonas aeruginosa; Quinolines | 1986 |
In vitro evaluation of A-56619 and A-56620, two new quinolones.
Topics: Anti-Bacterial Agents; Bacteria; Bacteria, Anaerobic; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Piperazines; Quinolines | 1986 |
[In vitro activity of seven gyrase inhibitors of a group of heterocyclic carbonic acids against nonfermenting gram negative rods (nonfermenters)].
Topics: Anti-Bacterial Agents; Cinoxacin; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Gram-Negative Aerobic Bacteria; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pipemidic Acid; Pseudomonas aeruginosa; Quinolines; Topoisomerase II Inhibitors | 1985 |
Clinical uses of nalidixic acid analogues: the fluoroquinolones.
Topics: Administration, Oral; Anti-Infective Agents; Bacterial Infections; Ciprofloxacin; Drug Evaluation; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Humans; Male; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines; Topoisomerase II Inhibitors | 1986 |
[Resistance against new gyrase inhibitors--1985/86].
Topics: Bacteria; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Topoisomerase II Inhibitors | 1987 |
Gyrase-inhibitors impair caffeine elimination in man.
Topics: Adult; Caffeine; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Kinetics; Male; Naphthyridines; Ofloxacin; Oxazines; Topoisomerase II Inhibitors | 1987 |
Endogenous active efflux of norfloxacin in susceptible Escherichia coli.
Topics: Anti-Infective Agents; Biological Transport, Active; Cell Membrane; Cell Membrane Permeability; Ciprofloxacin; Enoxacin; Escherichia coli; Kinetics; Norfloxacin; Ofloxacin; Spheroplasts | 1988 |
Effects of ethylenediaminetetraacetic acid and gentamicin on the antibacterial activity of pyridone carboxylic acid derivatives against gram-negative bacilli.
Topics: Anti-Bacterial Agents; Edetic Acid; Enoxacin; Gentamicins; Gram-Negative Bacteria; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Oxazines; Pyridones | 1986 |
[In vitro activity of new quinolones against nonfermenters and references to sensitivity tests].
Topics: Acinetobacter; Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Gram-Negative Bacteria; Immunodiffusion; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pipemidic Acid; Pseudomonas | 1986 |
Comparative in-vitro activity of five fluoroquinolones against mycobacteria.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Enoxacin; Mycobacterium; Mycobacterium avium; Mycobacterium bovis; Mycobacterium tuberculosis; Naphthyridines; Nontuberculous Mycobacteria; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1987 |
In-vitro activity of six fluorinated quinolones against Mycobacterium tuberculosis.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Isoniazid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Quinolines | 1987 |
[In vitro antibacterial activity of new derivatives of pyridonecarboxylic acid, norfloxacin, ofloxacin, enoxacin and ciprofloxacin, against Vibrio cholerae O-1].
Topics: Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Vibrio cholerae | 1987 |
[Comparative in vitro activity of 10 new 4-quinolones against enteropathogenic bacteria].
Topics: Anti-Bacterial Agents; Campylobacter fetus; Ciprofloxacin; Enoxacin; Enterobacteriaceae; Fleroxacin; Fluoroquinolones; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines; Salmonella; Shigella; Vibrio cholerae; Yersinia enterocolitica | 1987 |
Comparative in-vitro activity of Ro 23-6240, a new trifluorinated quinolone.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Enoxacin; Enterobacteriaceae; Fleroxacin; Fluoroquinolones; Gram-Negative Bacteria; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines | 1987 |
[Corynebacterium group D2. Clinical study, biochemical identification and antibiotic sensitivity].
Topics: Anti-Bacterial Agents; Ciprofloxacin; Corynebacterium; Corynebacterium Infections; Drug Resistance, Microbial; Enoxacin; Female; Humans; Male; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Peptides, Cyclic; Pipemidic Acid; Rifampin; Tetracycline; Tetracycline Resistance; Urinary Tract Infections; Vancomycin; Virginiamycin | 1988 |
[In vitro activity of new quinolones against Mycoplasma pathogenic to humans].
Topics: 4-Quinolones; Anti-Bacterial Agents; Ciprofloxacin; Enoxacin; Humans; Microbial Sensitivity Tests; Mycoplasma; Mycoplasma pneumoniae; Mycoplasmataceae; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines; Quinolones; Ureaplasma | 1988 |
Development of resistance to nalidixic acid and the fluoroquinolones after the introduction of norfloxacin and ofloxacin.
Topics: Anti-Infective Agents; Bacteria; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Enterobacteriaceae; Enterococcus faecalis; Humans; Nalidixic Acid; Norfloxacin; Ofloxacin; Pseudomonas aeruginosa; Staphylococcus aureus | 1988 |
Correlation of in vitro activities of the fluoroquinolones to their in vivo efficacies.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Enoxacin; Fleroxacin; Fluoroquinolones; Mice; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Pefloxacin; Quinolones | 1988 |
Comparative evaluation of recently developed quinolone compounds--with a note on the frequency of resistant mutants.
Topics: Acinetobacter; Ampicillin; Anti-Bacterial Agents; Bacteria; Cefotaxime; Ciprofloxacin; Enoxacin; Enterobacteriaceae; Enterococcus faecalis; Gentamicins; Haemophilus influenzae; Mezlocillin; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Penicillin Resistance; Pseudomonas aeruginosa; Quinolines; Staphylococcus aureus | 1985 |
The in-vitro activities of enoxacin and ofloxacin compared with that of ciprofloxacin.
Topics: Bacteria; Bacteria, Anaerobic; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Gram-Negative Aerobic Bacteria; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Oxazines; Quinolines; Staphylococcus; Streptococcus | 1985 |
Antichlamydial activity of quinolone carboxylic acids.
Topics: Chlamydia trachomatis; Ciprofloxacin; Enoxacin; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Quinolines | 1985 |
[Sensitivity of obligate anaerobes to ofloxacin, pefloxacin, enoxacin and norfloxacin].
Topics: Bacteria, Anaerobic; Bacteroides; Clostridium; Enoxacin; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin | 1985 |
Inhibition of the oxidative metabolism of theophylline in isolated rat hepatocytes by the quinolone antibiotic enoxacin and its metabolite oxoenoxacin, but not by ofloxacin.
Topics: Animals; Enoxacin; In Vitro Techniques; Liver; Male; Naphthyridines; Ofloxacin; Oxazines; Oxidation-Reduction; Quinolines; Rats; Structure-Activity Relationship; Theophylline | 1988 |
Effect of new quinolones on drug-metabolizing enzyme system of rat hepatic microsomes.
Topics: Animals; Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Enoxacin; Male; Microsomes, Liver; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Rats; Rats, Inbred Strains | 1988 |
In vitro activity of lomefloxacin (SC-47111; NY-198), a difluoroquinolone 3-carboxylic acid, compared with those of other quinolones.
Topics: Anaerobiosis; Anti-Bacterial Agents; Bacteria; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Humans; Hydrogen-Ion Concentration; Magnesium; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Quinolines; Quinolones | 1988 |
Comparative activities of cefuroxime, amoxicillin-clavulanic acid, ciprofloxacin, enoxacin, and ofloxacin against aerobic and anaerobic bacteria isolated from bite wounds.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Infective Agents; Bacteria; Bites and Stings; Bites, Human; Cats; Cefuroxime; Cephalosporins; Ciprofloxacin; Clavulanic Acids; Dogs; Drug Therapy, Combination; Enoxacin; Humans; Ofloxacin; Wound Infection | 1988 |
Effects of enoxacin, ofloxacin and norfloxacin on theophylline disposition in humans.
Topics: 17-Hydroxycorticosteroids; Adult; Aminophylline; Enoxacin; Female; Humans; Hydrocortisone; Male; Metabolic Clearance Rate; Norfloxacin; Ofloxacin; Theophylline | 1988 |
[Comparison of enoxacin, ofloxacin, and norfloxacin concentration in human benign prostatic tissue].
Topics: Administration, Oral; Enoxacin; Humans; Male; Norfloxacin; Ofloxacin; Prostate; Tissue Distribution | 1988 |
The influence of ofloxacin and enoxacin on the metabolic pathways of theophylline in healthy volunteers. A pilot study.
Topics: Adult; Dealkylation; Drug Interactions; Enoxacin; Humans; Kidney; Male; Ofloxacin; Oxidation-Reduction; Theophylline | 1988 |
In vitro activities of five new quinolones against 88 genital and neonatal Haemophilus isolates.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Enoxacin; Female; Genital Diseases, Female; Genital Diseases, Male; Haemophilus; Haemophilus Infections; Haemophilus influenzae; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1988 |
The comparative pharmacokinetics and tissue penetration of four quinolones including intravenously administered enoxacin.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Enoxacin; Half-Life; Humans; Kinetics; Male; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Tissue Distribution | 1986 |
Quinolone antimicrobial agents in acute exacerbations of chronic bronchitis.
Topics: Anti-Infective Agents; Bacterial Infections; Bronchitis; Ciprofloxacin; Enoxacin; Female; Humans; Male; Middle Aged; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin | 1986 |
[Gyrase inhibitors: unwanted central nervous system effects].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Brain Chemistry; Brain Diseases; Ciprofloxacin; Enoxacin; Humans; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Solubility | 1987 |
The comparative pharmacokinetics of five quinolones.
Topics: Administration, Oral; Adult; Ciprofloxacin; Enoxacin; Half-Life; Humans; Infusions, Intravenous; Kinetics; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin | 1986 |
In-vitro selection of bacteria resistant to the 4-quinolone agents.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Staphylococcus; Streptococcus | 1987 |
CI-934, a new difluoroquinolone: in vitro antibacterial activity and proposed disk diffusion test interpretive criteria.
Topics: Anti-Bacterial Agents; Bacteria; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Gram-Positive Bacteria; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Quinolines; Regression Analysis | 1987 |
Comparative in vitro activities of pefloxacin, ofloxacin, enoxacin and ciprofloxacin against 256 clinical isolates.
Topics: Anti-Bacterial Agents; Bacteria; Ciprofloxacin; Enoxacin; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin | 1987 |
Comparative in vitro activity of amifloxacin and five other fluoroquinolone antimicrobial agents and preliminary criteria for the disk susceptibility test.
Topics: Anti-Bacterial Agents; Bacteria; Ciprofloxacin; Enoxacin; Fluoroquinolones; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1987 |
The adverse effects of fluoroquinolones.
Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Humans; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1987 |
Lack of effect of ofloxacin on theophylline pharmacokinetics in rats.
Topics: Animals; Anti-Infective Agents; Blood Proteins; Cimetidine; Enoxacin; Male; Microsomes, Liver; Naphthyridines; Ofloxacin; Oxazines; Oxidoreductases; Protein Binding; Rats; Theophylline | 1987 |
Decrease of caffeine elimination in man during co-administration of 4-quinolones.
Topics: Adult; Anti-Infective Agents; Caffeine; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Enoxacin; Half-Life; Humans; Male; Naphthyridines; Ofloxacin; Oxazines; Quinolines | 1987 |
Steady-state kinetics of the quinolone derivatives ofloxacin, enoxacin, ciprofloxacin and pefloxacin during maintenance treatment with theophylline.
Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Drug Interactions; Enoxacin; Female; Humans; Male; Middle Aged; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines; Theophylline | 1987 |
Comparative pharmacokinetics of new quinolones.
Topics: Anti-Infective Agents; Chromatography, High Pressure Liquid; Enoxacin; Humans; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1987 |
[Fluoroquinolones].
Topics: Bacteria; Chemical Phenomena; Chemistry; Ciprofloxacin; Enoxacin; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Quinolines | 1987 |
Comparative evaluation of enoxacin, ofloxacin, ampicillin, and chloramphenicol for treatment of experimental Haemophilus influenzae pneumonia.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Chloramphenicol; Enoxacin; Female; Haemophilus Infections; Haemophilus influenzae; Kinetics; Lung; Male; Mice; Naphthyridines; Ofloxacin; Oxazines; Pneumonia | 1987 |
Clinical efficacy of the new quinolones in lower respiratory infections.
Topics: Aged; Anti-Infective Agents; Bacteria; Ciprofloxacin; Enoxacin; Humans; Microbial Sensitivity Tests; Middle Aged; Ofloxacin; Pefloxacin; Respiratory Tract Infections; Sputum | 1987 |
Elimination of plasmids by enoxacin and ofloxacin at near inhibitory concentrations.
Topics: Enoxacin; Escherichia coli; Kinetics; Naphthyridines; Ofloxacin; Oxazines; Plasmids | 1986 |
Frequency and expression of mutational resistance to the 4-quinolone antibacterials.
Topics: 4-Quinolones; Anti-Bacterial Agents; Cinoxacin; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Escherichia coli; Fluoroquinolones; Mutation; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Oxolinic Acid; Pipemidic Acid; Quinolines; Quinolizines; Quinolones | 1986 |
The in-vitro activity of EN 272, a quinolone-7-carboxylic acid, in comparison with other quinolones.
Topics: Anti-Bacterial Agents; Bacteria; Enoxacin; Humans; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Quinolines; Quinolones; Structure-Activity Relationship; Urinary Tract Infections | 1985 |
In-vitro activity of ofloxacin, a quinolone carboxylic acid compared to other quinolones and other antimicrobial agents.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Drug Resistance, Microbial; Enoxacin; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Mutation; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines | 1985 |
In-vitro activity of enoxacin, ofloxacin, norfloxacin and nalidixic acid.
Topics: Bacteria; Bacterial Infections; Enoxacin; Humans; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines | 1984 |
In vitro activity of eight antibiotics against Salmonella and Shigella species.
Topics: Ampicillin; Anti-Bacterial Agents; Chloramphenicol; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Fleroxacin; Microbial Sensitivity Tests; Ofloxacin; Pefloxacin; Salmonella; Shigella; Trimethoprim, Sulfamethoxazole Drug Combination | 1994 |
In vitro phototoxic activities of new quinolone antibacterial agents: lipid peroxidative potentials.
Topics: Absorption; Anti-Infective Agents; Azides; Ciprofloxacin; Dermatitis, Phototoxic; Enoxacin; Fluoroquinolones; Humans; In Vitro Techniques; Lipid Peroxidation; Norfloxacin; Ofloxacin; Oxygen; Photochemistry; Photosensitivity Disorders; Quinolones; Sodium Azide; Squalene; Ultraviolet Rays | 1994 |
Dissociation and complexation of fluoroquinolone analogues.
Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Ferric Compounds; Models, Theoretical; Norfloxacin; Ofloxacin; Spectrophotometry | 1994 |
Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway?
Topics: Biological Transport; Carbon Radioisotopes; Cells, Cultured; Ciprofloxacin; Enoxacin; Fleroxacin; Fluoroquinolones; Humans; Intestinal Mucosa; Norfloxacin; Ofloxacin; Pefloxacin; Quinolizines | 1994 |
Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide.
Topics: Aluminum Hydroxide; Animals; Buffers; Chemical Phenomena; Chemistry, Physical; Chloroform; Drug Interactions; Enoxacin; Intestinal Absorption; Levofloxacin; Male; Norfloxacin; Ofloxacin; Phosphates; Rats; Rats, Sprague-Dawley | 1993 |
Antibacterial activity of NM394, the active form of prodrug NM441, a new quinolone.
Topics: Anti-Infective Agents; Bacteria; Ciprofloxacin; Dioxolanes; Enoxacin; Fluoroquinolones; Microbial Sensitivity Tests; Mutation; Naphthyridines; Ofloxacin; Piperazines; Quinolones; Topoisomerase II Inhibitors | 1993 |
[Comparison of in-vitro and in-vivo activities of enoxacin and ofloxacin against the Mycobacterium tuberculosis].
Topics: Animals; Antitubercular Agents; Enoxacin; Female; Male; Mice; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium tuberculosis; Ofloxacin; Tuberculosis | 1995 |
Proposed criteria for interpretation of susceptibilities of strains of Neisseria gonorrhoeae to ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, and norfloxacin.
Topics: Anti-Infective Agents; Ciprofloxacin; Diffusion; Drug Resistance, Microbial; Enoxacin; Fluoroquinolones; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Norfloxacin; Ofloxacin; Quinolones | 1995 |
Detection of quinolone-resistant Neisseria gonorrhoeae.
Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enoxacin; Female; Fleroxacin; Fluoroquinolones; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Ofloxacin; Quinolones; Reference Standards | 1996 |
Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Dermatitis, Phototoxic; DNA; DNA Damage; Enoxacin; Fluoroquinolones; Free Radical Scavengers; Hematoporphyrins; Molecular Structure; Ofloxacin; Oxygen; Photosensitizing Agents; Quinolones; Reactive Oxygen Species; Spectroscopy, Near-Infrared; Superoxides | 1997 |
Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Ciprofloxacin; Convulsants; Cyclic AMP; Dizocilpine Maleate; Enoxacin; Enzyme Inhibitors; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ofloxacin; Phenylacetates; Seizures | 1997 |
Retention behaviour of quinolone derivatives in high-performance liquid chromatography. Effect of pH and evaluation of ionization constants.
Topics: Acetonitriles; Anti-Infective Agents; Chromatography, High Pressure Liquid; Enoxacin; Fleroxacin; Fluoroquinolones; Hydrogen-Ion Concentration; Norfloxacin; Ofloxacin; Osmolar Concentration; Potentiometry; Quinolizines; Quinolones; Thermodynamics; Water | 1998 |
Structure and medium-dependent photodecomposition of fluoroquinolone antibiotics.
Topics: Anti-Infective Agents; Enoxacin; Fluoroquinolones; Norfloxacin; Ofloxacin; Photolysis; Photosensitizing Agents; Quantum Theory; Quinolones; Structure-Activity Relationship | 1998 |
Can quinolones cause hemorrhagic colitis of late onset? Report of three cases.
Topics: Acute Disease; Adult; Anti-Infective Agents; Bacterial Infections; Colitis; Colonoscopy; Enoxacin; Female; Fluoroquinolones; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naphthyridines; Ofloxacin | 1999 |
Analyses of cutaneous fluoroquinolones photoreactivity using the integrated model for the differentiation of skin reactions.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Infective Agents; Biomarkers; Cell Membrane; Enoxacin; Female; Fluoroquinolones; Irritants; Mice; Models, Biological; Ofloxacin; Phenotype; Photosensitizing Agents; Quinolones; Skin | 2000 |
Profiles of hepatic and dysrhythmic cardiovascular events following use of fluoroquinolone antibacterials: experience from large cohorts from the Drug Safety Research Unit Prescription-Event Monitoring database.
Topics: Adult; Aged; Anti-Infective Agents; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Ciprofloxacin; Cohort Studies; Databases, Factual; Drug Monitoring; England; Enoxacin; Family Practice; Female; Humans; Liver Diseases; Male; Middle Aged; Norfloxacin; Ofloxacin; Product Surveillance, Postmarketing; Retrospective Studies; Surveys and Questionnaires; Time Factors | 2001 |
[Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies].
Topics: Animals; Anti-Infective Agents; Cells, Cultured; Ciprofloxacin; Dermatitis, Phototoxic; Enoxacin; Female; Fluoroquinolones; Guinea Pigs; Nalidixic Acid; Ofloxacin; Oxazines; Quinolones; Rats; Rats, Sprague-Dawley; Ultraviolet Rays | 2002 |
Binding characteristics of fluoroquinolones to synthetic levodopa melanin.
Topics: Binding Sites; Chloroquine; Ciprofloxacin; Drug Interactions; Enoxacin; Fluoroquinolones; Levodopa; Levofloxacin; Melanins; Monophenol Monooxygenase; Norfloxacin; Ofloxacin; Quinolones; Timolol | 2003 |
Effects of eight antibacterial agents on cell survival and expression of epithelial-cell- or cell-adhesion-related genes in human gingival epithelial cells.
Topics: Anti-Bacterial Agents; Azithromycin; Cell Adhesion; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Clarithromycin; Enoxacin; Epithelial Cells; Erythromycin; Fibroblast Growth Factors; Gingiva; Humans; Integrins; Keratins; Laminin; Lethal Dose 50; Minocycline; Ofloxacin; Proteins; Roxithromycin; Tetracycline | 2004 |
[Analysis of the response factors of different quinolones detected by evaporative light-scattering detector].
Topics: Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Fluoroquinolones; Gatifloxacin; Levofloxacin; Light; Linear Models; Ofloxacin; Quinolones | 2003 |
Corneal and scleral permeability of quinolones--a pharmacokinetics study.
Topics: Administration, Topical; Animals; Aqueous Humor; Cell Membrane Permeability; Cinoxacin; Ciprofloxacin; Conjunctiva; Cornea; Enoxacin; Nalidixic Acid; Norfloxacin; Ofloxacin; Quinolones; Rabbits; Sclera; Time Factors; Water | 2003 |
[Simultaneous determination of quinolones in foods by LC/MS/MS].
Topics: Animals; Chromatography, Liquid; Ciprofloxacin; Enoxacin; Enrofloxacin; Fishes; Fluoroquinolones; Food Analysis; Meat; Ofloxacin; Quinolones; Spectrometry, Mass, Electrospray Ionization | 2004 |
Vibrational spectroscopic characterization of fluoroquinolones.
Topics: Aza Compounds; Cinoxacin; Ciprofloxacin; DNA Gyrase; DNA, Bacterial; Enoxacin; Enzyme Inhibitors; Fluoroquinolones; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Chemical; Models, Molecular; Models, Theoretical; Moxifloxacin; Nalidixic Acid; Norfloxacin; Ofloxacin; Oxolinic Acid; Quinolines; Quinolones; Spectrophotometry, Infrared; Spectrum Analysis, Raman; Temperature; Ultraviolet Rays; Vibration; Water | 2005 |
HPLC determination of enoxacin, ciprofloxacin, norfloxacin and ofloxacin with photoinduced fluorimetric (PIF) detection and multiemission scanning: application to urine and serum.
Topics: Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Fluoroquinolones; Humans; Hydrogen-Ion Concentration; Norfloxacin; Ofloxacin; Sensitivity and Specificity; Spectrometry, Fluorescence | 2005 |
Electrochemiluminescence of terbium (III)-two fluoroquinolones-sodium sulfite system in aqueous solution.
Topics: Electrochemistry; Enoxacin; Luminescence; Ofloxacin; Solutions; Sulfites; Terbium; Water | 2006 |
In vitro activity of lomefloxacin, a new difluorinated quinolone, against urinary bacterial isolates: comparison with enoxacin and ofloxacin.
Topics: Anti-Infective Agents; Bacteria; Enoxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Ofloxacin; Quinolones; Urinary Tract Infections | 1989 |
T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antigen-Presenting Cells; Aza Compounds; Cell Proliferation; Cells, Cultured; Ciprofloxacin; Clone Cells; Cross Reactions; Drug Hypersensitivity; Enoxacin; Female; Fluoroquinolones; Humans; Hypersensitivity, Delayed; Middle Aged; Moxifloxacin; Nalidixic Acid; Norfloxacin; Ofloxacin; Patch Tests; Pipemidic Acid; Quinolines; Quinolones; T-Lymphocytes | 2006 |
Effects of Transcutol P on the corneal permeability of drugs and evaluation of its ocular irritation of rabbit eyes.
Topics: 1-Octanol; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Cornea; Drug Carriers; Enoxacin; Ethylene Glycols; Eye; Fluoroquinolones; Gatifloxacin; In Vitro Techniques; Irritants; Levofloxacin; Ofloxacin; Oxaprozin; Permeability; Propionates; Rabbits; Ribavirin; Water | 2006 |
Selective action of fluoroquinolones against intracellular amastigotes of Leishmania (Viannia) panamensis in vitro.
Topics: Animals; Cell Line; Cinoxacin; Ciprofloxacin; Enoxacin; Fluoroquinolones; Humans; Leishmania guyanensis; Macrophages; Nalidixic Acid; Norfloxacin; Ofloxacin; Quinolones | 2005 |
A rapid CE-potential gradient detection method for determination of quinolones.
Topics: Animals; Electrophoresis, Capillary; Enoxacin; Fleroxacin; Fluoroquinolones; Methods; Milk; Ofloxacin; Oxazines; Quinolones | 2007 |
[Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].
Topics: Animals; Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Enrofloxacin; Fluoroquinolones; Norfloxacin; Ofloxacin; Pefloxacin; Quinolones; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2007 |
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Ciprofloxacin; Diclofenac; Dioxolanes; Drug Combinations; Drug Interactions; Enoxacin; Fleroxacin; Fluoroquinolones; Gatifloxacin; Levofloxacin; Male; Mice; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Phenylacetates; Piperazines; Receptors, GABA-A; Seizures | 2009 |
Determination of enoxacin and ofloxacin by capillary electrophoresis with electrochemiluminescence detection in biofluids and drugs and its application to pharmacokinetics.
Topics: Electrophoresis, Capillary; Enoxacin; Female; Humans; Hydrogen-Ion Concentration; Luminescent Measurements; Ofloxacin; Reproducibility of Results | 2010 |
Should moxifloxacin be used for the treatment of extensively drug-resistant tuberculosis? An answer from a murine model.
Topics: Animals; Antitubercular Agents; Aza Compounds; DNA Gyrase; Enoxacin; Fluoroquinolones; Gatifloxacin; Mice; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Mycobacterium tuberculosis; Ofloxacin; Quinolines; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2010 |
Application of non-linear angle synchronous spectrofluorimetry to the determination of complex mixtures of drugs in urine: a comparative study.
Topics: Anti-Infective Agents; Calibration; Enoxacin; Humans; Least-Squares Analysis; Limit of Detection; Ofloxacin; Pefloxacin; Spectrometry, Fluorescence | 2012 |
Inhibitory effect of ciprofloxacin on β-glucuronidase-mediated deconjugation of mycophenolic acid glucuronide.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Enoxacin; Enterohepatic Circulation; Glucuronidase; Glucuronides; Immunosuppressive Agents; In Vitro Techniques; Inhibitory Concentration 50; Levofloxacin; Mycophenolic Acid; Ofloxacin; Phenolphthaleins; Time Factors | 2014 |
Antibiotic Sensitivity pattern of Bacterial Isolates of Neonatal Septicemia in Peshawar, Pakistan.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Enoxacin; Escherichia coli; Escherichia coli Infections; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Imipenem; Infant, Low Birth Weight; Infant, Newborn; Klebsiella; Klebsiella Infections; Male; Microbial Sensitivity Tests; Neonatal Sepsis; Ofloxacin; Pakistan; Proteus; Proteus Infections; Pseudomonas; Pseudomonas Infections; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis | 2016 |
A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein.
Topics: Alternative Splicing; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Damage; Down-Regulation; Enoxacin; Female; Humans; Melanoma; Ofloxacin; Ovarian Neoplasms; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Tumor Suppressor Protein p53 | 2017 |
The influence mechanism of the molecular structure on the peak current and peak potential in electrochemical detection of typical quinolone antibiotics.
Topics: Anti-Bacterial Agents; Catalysis; Electrochemical Techniques; Enoxacin; Molecular Structure; Norfloxacin; Ofloxacin; Oxidation-Reduction; Quinolones; Water; Water Pollutants, Chemical | 2021 |