ofloxacin has been researched along with antofloxacin in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, J; Liu, H; Liu, X; Wang, G; Xie, L | 1 |
| Kang, Z; Li, T; Liu, Y; Lu, Y; Xiao, Y; Zhang, M | 1 |
| Hou, F; Kang, Z; Li, T; Liu, Y; Lu, Y; Wang, S; Xia, Y; Xiao, Y | 1 |
| Liu, L; Liu, XD; Pang, XY; Wang, GJ; Xie, L; Zhang, DM | 1 |
| Xiao, XM; Xiao, YH | 1 |
| Qi, HM; Wei, MJ; Zhang, L; Zhao, CY | 1 |
| Liao, J; Liu, XD; Wang, GJ; Xie, L; Zhu, Q | 1 |
| Kang, A; Liang, Y; Liu, L; Liu, X; Lu, S; Sheng, L; Wang, GJ; Xie, L; Xie, T; Xie, Y | 1 |
| Kang, Z; Li, T; Liang, J; Liu, Y; Lu, Y; Wang, J; Xiao, Y; Zhang, M | 2 |
| Guo, J; Han, SN; Hu, ZS; Liu, JX; Shi, J; Zhang, LR; Zhang, XM; Zhang, Z; Zhao, ZZ | 1 |
| Bai, C; Huang, W; Mei, C; Wang, J; Xiao, Y; Xiu, Q; Xu, N; Zheng, Q | 1 |
| Kang, ZS; Li, TY; Liu, Y; Lü, Y; Xiao, YH; Zhang, M; Zhu, Y | 1 |
| Hu, N; Liu, L; Liu, X; Pan, X; Wang, G; Wang, P; Xie, L | 1 |
| Chen, P; Cui, H; Huang, WX; Jia, ZP; Li, DT; Mao, GG; Wen, AD; Xiao, YH; Xiu, QY; Xue, F; Yang, GP | 1 |
| Cheng, JL; Fan, HW; Liu, HY; Liu, L; Liu, XD; Pan, X; Xiao, DW; Xie, L; Yang, HW | 1 |
| He, YC; Huang, JH; Li, YF; Wang, K; Yin, F; Zheng, QS | 1 |
| Guo, P; Ji, T; Jiang, X; Lin, Z; Liu, Y; Wang, W; Xu, Y; Zhang, P; Zhao, J | 1 |
| Huo, W; Liu, H; Shan, J; Wang, W; Xie, G; Zhang, W; Zhou, X | 1 |
| Chen, S; Dong, L; Huang, H; Köser, CU; Moradigaravand, D; Parkhill, J; Peacock, SJ; Schön, T; Shang, Y; Wang, G; Wei, G; Yu, X | 1 |
| Chen, J; Huang, M; Liu, Y; Ma, Y; Ou, N; Sun, L; Wang, L; Wang, Q; Wang, Y; Xie, L; Zhang, H | 1 |
| He, YC; Huang, JH; Li, LJ; Li, YF; Liang, LY; Wang, K; Xu, FY; Yang, J; Zheng, QS | 1 |
| He, XJ; Jiang, CS; Li, DZ; Liu, G; Wang, W; Zeng, XP | 2 |
12 trial(s) available for ofloxacin and antofloxacin
| Article | Year |
|---|---|
Pharmacokinetics of antofloxacin hydrochloride, a new fluoroquinolone antibiotic, after single oral dose administration in Chinese healthy male volunteers.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Asian People; China; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Half-Life; Humans; Levofloxacin; Male; Ofloxacin; Tissue Distribution | 2008 |
Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers.
Topics: Adult; Asian People; China; Dose-Response Relationship, Drug; Fluoroquinolones; Health; Humans; Injections, Intravenous; Male; Ofloxacin; Time Factors; Young Adult | 2010 |
A phase II study of antofloxacin hydrochloride, a novel fluoroquinolone, for the treatment of acute bacterial infections.
Topics: Acute Disease; Adult; Aged; Anti-Bacterial Agents; Bronchitis, Chronic; Demography; Double-Blind Method; Female; Humans; Levofloxacin; Male; Middle Aged; Ofloxacin; Pyelonephritis | 2010 |
Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Humans; Levofloxacin; Male; Ofloxacin; Young Adult | 2011 |
Pharmacokinetics of antofloxacin hydrochloride in healthy male subjects after multiple intravenous dose administration.
Topics: Adult; Dose-Response Relationship, Drug; Health; Humans; Injections, Intravenous; Male; Ofloxacin; Time Factors; Young Adult | 2011 |
[A multi-center, randomized, controlled, double blind and double dummy clinical trial of antofloxacin hydrochloride tablet versus levofloxacin tablet for the treatment of acute bacterial infections].
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Double-Blind Method; Female; Humans; Levofloxacin; Male; Middle Aged; Ofloxacin; Young Adult | 2011 |
Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans.
Topics: Adult; Anti-Bacterial Agents; Bronchodilator Agents; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Female; Humans; Male; Microsomes, Liver; Ofloxacin; Theophylline; Young Adult | 2011 |
Dose findings of antofloxacin hydrochloride for treating bacterial infections in an early clinical trial using PK-PD parameters in healthy volunteers.
Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Bacteria; Bacterial Infections; Body Weight; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Microbial Sensitivity Tests; Models, Biological; Ofloxacin; Sex Factors; Young Adult | 2012 |
Simultaneous quantification of antofloxacin and its major metabolite in human urine by HPLC-MS/MS, and its application to a pharmacokinetic study.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Linear Models; Male; Middle Aged; Ofloxacin; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Young Adult | 2017 |
Relationship between antofloxacin concentration and QT prolongation and estimation of the possible false-positive rate.
Topics: Adult; Anti-Bacterial Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; False Positive Reactions; Female; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome; Male; Models, Statistical; Moxifloxacin; Ofloxacin; Young Adult | 2020 |
Antofloxacin-based bismuth quadruple therapy is safe and effective in Helicobacter pylori eradication: A prospective, open-label, randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Bismuth; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Humans; Ofloxacin; Prospective Studies; Proton Pump Inhibitors; Treatment Outcome | 2021 |
Efficacy and Safety of Antofloxacin-Based Triple Therapy for Helicobacter pylori Eradication Failure in China.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Breath Tests; China; Drug Therapy, Combination; Esomeprazole; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Male; Microbial Sensitivity Tests; Ofloxacin; Proton Pump Inhibitors; Treatment Outcome | 2022 |
12 other study(ies) available for ofloxacin and antofloxacin
| Article | Year |
|---|---|
Possible multiple transporters were involved in hepatobiliary excretion of antofloxacin in rats.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bile; Biological Transport; Cimetidine; Cyclosporine; Diclofenac; Enzyme Inhibitors; Erythromycin; Liver; Male; Membrane Transport Proteins; Ofloxacin; Probenecid; Rats; Rats, Sprague-Dawley; Uricosuric Agents | 2007 |
Tolerability and pharmacokinetics of antofloxacin hydrochloride after multiple oral dose administration in healthy Chinese male volunteers.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; China; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluoroquinolones; Humans; Male; Ofloxacin | 2008 |
The pharmacokinetics of antofloxacin in renally impaired rats.
Topics: Animals; Anti-Bacterial Agents; Cisplatin; Kidney Diseases; Male; Ofloxacin; Rats; Rats, Sprague-Dawley | 2008 |
Pharmacokinetics/pharmacodynamics of antofloxacin hydrochloride in a neutropenic murine thigh model of Staphylococcus aureus infection.
Topics: Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Ofloxacin; Staphylococcal Infections; Thigh | 2008 |
Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes.
Topics: Animals; Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; Aza Compounds; Ciprofloxacin; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Fluoroquinolones; Gatifloxacin; Humans; Isoenzymes; Levofloxacin; Microsomes, Liver; Molecular Structure; Moxifloxacin; Ofloxacin; Quinolines; Reproducibility of Results | 2008 |
Mechanism-based inhibition of CYP1A2 by antofloxacin, an 8-NH2 derivative of levofloxacin in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Kinetics; Levofloxacin; Male; Microsomes, Liver; Models, Biological; Ofloxacin; Phenacetin; Rats; Rats, Sprague-Dawley | 2009 |
Application of a hybrid ion trap/time-of-flight mass spectrometer in metabolite characterization studies: structural identification of the metabolism profile of antofloxacin in rats rapidly using MSn information and accurate mass measurements.
Topics: Animals; Bile; Biotransformation; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Ions; Male; Mass Spectrometry; Models, Chemical; Ofloxacin; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Software | 2009 |
The action of a novel fluoroquinolone antibiotic agent antofloxacin hydrochloride on human-ether-à-go-go-related gene potassium channel.
Topics: Anti-Bacterial Agents; Cell Line; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoroquinolones; Gene Expression Regulation; Humans; Kidney; Levofloxacin; Ofloxacin; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Transport; Structure-Activity Relationship; Transfection | 2010 |
A physiologically based pharmacokinetic model characterizing mechanism-based inhibition of CYP1A2 for predicting theophylline/antofloxacin interaction in both rats and humans.
Topics: Animals; Area Under Curve; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Fluoroquinolones; Humans; Liver; Male; Microsomes, Liver; Models, Animal; Models, Theoretical; Ofloxacin; Phosphodiesterase Inhibitors; Rats; Theophylline | 2011 |
Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study.
Topics: Electron Transport; Electrophoresis, Polyacrylamide Gel; Energy Transfer; Fluoroquinolones; Lasers, Solid-State; Levofloxacin; Ofloxacin; Photolysis; Quantum Theory | 2016 |
Preparation of a novel chitosan-microcapsules/starch blend film and the study of its drug-release mechanism.
Topics: Buffers; Chitosan; Drug Carriers; Drug Liberation; Hydrogen-Ion Concentration; Mechanical Phenomena; Ofloxacin; Permeability; Starch; Temperature; Water | 2016 |
Wild-Type and Non-Wild-Type Mycobacterium tuberculosis MIC Distributions for the Novel Fluoroquinolone Antofloxacin Compared with Those for Ofloxacin, Levofloxacin, and Moxifloxacin.
Topics: Antitubercular Agents; China; DNA Gyrase; Drug Dosage Calculations; Drug Resistance, Bacterial; Fluoroquinolones; Gene Expression; Genotype; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Mycobacterium tuberculosis; Ofloxacin; Tuberculosis, Pulmonary | 2016 |