octaarginine and vindoline

octaarginine has been researched along with vindoline* in 1 studies

Other Studies

1 other study(ies) available for octaarginine and vindoline

Article	Year
The effect of conjugation on antitumor activity of vindoline derivatives with octaarginine, a cell-penetrating peptide. Journal of peptide science : an official publication of the European Peptide Society, 2018, Volume: 24, Issue:10 Some Vinca alkaloids (eg, vinblastine, vincristine) have been widely used as antitumor drugs for a long time. Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our novel research program, we have prepared and identified new vindoline derivatives with moderate cytostatic activity. Here, we describe the effect of conjugation of vindoline derivative with oligoarginine (tetra-, hexa-, or octapeptides) cell-penetrating peptides on the cytostatic activity in vitro and in vivo. Br-Vindoline-(l)-Trp-OH attached to the N-terminus of octaarginine was the most effective compound in vitro on HL-60 cell line. Analysis of the in vitro activity of two isomer conjugates (Br-vindoline-(l)-Trp-Arg Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell-Penetrating Peptides; HL-60 Cells; Humans; Leukemia; Mice; Molecular Structure; Oligopeptides; Vinblastine; Xenograft Model Antitumor Assays	2018

Article

Year

The effect of conjugation on antitumor activity of vindoline derivatives with octaarginine, a cell-penetrating peptide.

Journal of peptide science : an official publication of the European Peptide Society, 2018, Volume: 24, Issue:10

Some Vinca alkaloids (eg, vinblastine, vincristine) have been widely used as antitumor drugs for a long time. Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our novel research program, we have prepared and identified new vindoline derivatives with moderate cytostatic activity. Here, we describe the effect of conjugation of vindoline derivative with oligoarginine (tetra-, hexa-, or octapeptides) cell-penetrating peptides on the cytostatic activity in vitro and in vivo. Br-Vindoline-(l)-Trp-OH attached to the N-terminus of octaarginine was the most effective compound in vitro on HL-60 cell line. Analysis of the in vitro activity of two isomer conjugates (Br-vindoline-(l)-Trp-Arg

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell-Penetrating Peptides; HL-60 Cells; Humans; Leukemia; Mice; Molecular Structure; Oligopeptides; Vinblastine; Xenograft Model Antitumor Assays

2018