octaarginine and 2-2--dipicolylamine
octaarginine has been researched along with 2-2--dipicolylamine* in 1 studies
Other Studies
1 other study(ies) available for octaarginine and 2-2--dipicolylamine
Article | Year |
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Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine.
Marked promotion of membrane permeation of a cell-penetrating peptide, octaarginine (R8), was attained by attachment to a single 2,2'-dipicolylamine moiety (DPA-R8) that forms 1:1 complexes with metal ions. Studies using giant unilamellar vesicles demonstrated that DPA targets phospholipids and enhances R8 binding to the membranes in the presence of metal ions. While DPA/Zn(II) complex has been most frequently employed for chelate formation with phosphates, Ni(II) had the most prominent effect on the membrane binding and penetration of DPA-R8. Facile cytosolic distribution of DPA-R8 was also attained in a few minutes in the presence of Ni(II). Analysis of the cellular uptake methods of DPA-R8/Ni(II) suggested the involvement of direct permeation through cell membrane without the use of endocytosis. The applicability of this system to the intracellular delivery of bioactive compounds was exemplified using a peptidomimetic farnesyltransferase inhibitor, FTI277. Topics: Amines; Cell Membrane; Cell Membrane Permeability; Cell-Penetrating Peptides; Coordination Complexes; Drug Carriers; Endocytosis; HeLa Cells; Humans; Methionine; Oligopeptides; Picolinic Acids; Zinc | 2019 |