obtusifoliol has been researched along with lanosterol in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friggeri, L; Guengerich, FP; Hargrove, TY; Lepesheva, GI; Wawrzak, Z | 1 |
| Guengerich, FP; Hargrove, TY; Lepesheva, GI; Nes, WD; Rachakonda, G; Villalta, F; Wawrzak, Z | 1 |
| Brown, RG; Morris, DC; Safe, L; Safe, S; Subden, RE | 1 |
| Rahier, A; Taton, M | 1 |
| Denning, DW; Kelly, SL; Manning, NJ; Venkateswarlu, K | 1 |
| Batard, Y; Cabello-Hurtado, F; DeRose, R; Durst, F; Nedelkina, S; Pallett, KE; Rahier, A; Taton, M; Werck-Reichhart, D; Zimmerlin, A | 1 |
| Kelly, DE; Kelly, SL; Lamb, DC | 1 |
| Friggeri, L; Guengerich, FP; Hargrove, TY; Hiebert, SW; Lepesheva, GI; Sivakumaran, S; Waterman, MR; Wawrzak, Z; Yazlovitskaya, EM | 1 |
| Bailen, M; Benharref, A; Gonzalez-Coloma, A; Khamlichi, MD; Martinez-Diaz, RA | 1 |
| Churchman, LR; De Voss, JJ; Salisbury, LJ | 1 |
10 other study(ies) available for obtusifoliol and lanosterol
| Article | Year |
|---|---|
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.
Topics: 14-alpha Demethylase Inhibitors; Animals; Catalytic Domain; Crystallography, X-Ray; Drug Design; Humans; Molecular Structure; Mutagenesis, Site-Directed; Protozoan Proteins; Sterol 14-Demethylase | 2019 |
Relaxed Substrate Requirements of Sterol 14α-Demethylase from
Topics: 14-alpha Demethylase Inhibitors; Ligands; Naegleria fowleri; Sterol 14-Demethylase; Substrate Specificity | 2021 |
Eburicol, lichesterol, ergosterol, and obtusifoliol from polyene antibiotic-resistant mutants of Candida albicans.
Topics: Amphotericin B; Candicidin; Candida albicans; Cholestadienols; Drug Resistance, Microbial; Ergosterol; Lanosterol; Mutation; Natamycin; Nystatin; Phytosterols; Triterpenes | 1977 |
Plant sterol biosynthesis: 7-oxo-obtusifoliol analogues as potential selective inhibitors of cytochrome P-450 dependent obtusifoliol 14 alpha-demethylase.
Topics: Cells, Cultured; Cholestadienols; Cytochrome P-450 Enzyme Inhibitors; Eucalyptus; Hordeum; Lanosterol; Oxidoreductases; Phytosterols; Plants, Medicinal; Sterol 14-Demethylase; Suspensions; Zea mays | 1992 |
Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida albicans; Candidiasis, Chronic Mucocutaneous; Cholestadienols; Cytochrome P-450 Enzyme System; Drug Resistance, Microbial; Ergosterol; Fluconazole; Humans; Lanosterol; Microbial Sensitivity Tests; Oxidoreductases; Sterol 14-Demethylase | 1995 |
Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14alpha-demethylase (CYP51) in wheat.
Topics: Amino Acid Sequence; Base Sequence; Cholestadienols; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA Primers; DNA, Complementary; Evolution, Molecular; Gene Library; Lanosterol; Microsomes; Molecular Sequence Data; Oxidoreductases; Phylogeny; Phytosterols; Polymerase Chain Reaction; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Sterol 14-Demethylase; Substrate Specificity; Triticum | 1997 |
Molecular diversity of sterol 14alpha-demethylase substrates in plants, fungi and humans.
Topics: Candida albicans; Cholestadienols; Cytochrome P-450 Enzyme System; Edible Grain; Humans; Lanosterol; Molecular Structure; Oxidoreductases; Sterol 14-Demethylase; Substrate Specificity | 1998 |
Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design.
Topics: 14-alpha Demethylase Inhibitors; Antifungal Agents; Antineoplastic Agents; Antiprotozoal Agents; Catalytic Domain; Cell Line, Tumor; Cholestadienols; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Hydrogen Bonding; Lanosterol; Models, Molecular; Protein Binding; Protein Conformation, alpha-Helical; Sterol 14-Demethylase | 2016 |
New Bioactive Semisynthetic Derivatives of 31-Norlanostenol and Obtusifoliol from Euphorbia officinarum.
Topics: Animals; Antiparasitic Agents; CHO Cells; Cholestadienols; Cricetinae; Cricetulus; Euphorbia; Lanosterol; Leishmania infantum; Molecular Structure; Plant Extracts; Trypanosoma cruzi | 2016 |
Synthesis of obtusifoliol and analogues as CYP51 substrates.
Topics: Antifungal Agents; Azoles; Cholestadienols; Cytochrome P-450 Enzyme System; Lanosterol; Sterol 14-Demethylase; Sterols | 2022 |