obidoxime chloride has been researched along with trimedoxime bromide in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (23.08) | 18.7374 |
| 1990's | 2 (5.13) | 18.2507 |
| 2000's | 17 (43.59) | 29.6817 |
| 2010's | 11 (28.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naneva, E | 1 |
| Bajgar, J; Hrdina, V; Jakl, A; Patocka, J | 1 |
| Bajgar, J; Fusek, J; Jakl, A; Patocka, J | 1 |
| Jepsen, K; Lüllmann, H; Mohr, K; Pfeffer, J | 1 |
| Balderman, D; Galron, R; Kloog, Y; Sokolovsky, M | 1 |
| Ding, XJ; Ding, Y; Xue, SZ | 1 |
| Pícha, B | 1 |
| Ardab'eva, TV; Khramova, EA; Prozorovskiĭ, VB | 1 |
| Chowdhri, BL; Das Gupta, S; Ghosh, AK; Moorthy, MV | 1 |
| Chowdhri, BL; Das Gupta, S; Ghosh, AK; Jaiswal, DK; Moorthy, MV; Pant, BP | 1 |
| Jokanović, M; Maksimović, M | 1 |
| Du, X; Li, J; Sun, M; Zhang, Y | 1 |
| Antonijevic, B; Bokonjic, D; Milovanovic, ZA; Nedeljkovic, M; Stefanovic, D; Stojiljkovic, MP | 1 |
| Cabal, J; Hrabinova, M; Jun, D; Kassa, J; Kuca, K | 1 |
| Reiner, E; Simeon-Rudolf, V | 1 |
| Cabal, J; Hrabinova, M; Jun, D; Kuca, K | 1 |
| Bajgar, J; Jun, D; Kuca, K | 1 |
| Antonijevic, B; Stojiljkovic, MP | 1 |
| Karasova, J; Kassa, J; Kuca, K; Musilek, K | 1 |
| Humlicek, V; Kassa, J | 1 |
| Jung, YS; Karasova, J; Kassa, J; Kuca, K; Musilek, K | 1 |
| Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Pohanka, M | 1 |
| Bajgar, J; Karasova, J; Kassa, J; Kopelikova, I; Kuca, K; Musilek, K | 1 |
| Hasan, MY; Kuca, K; Lorke, DE; Nurulain, SM; Petroianu, GA; Schmitt, A | 1 |
| Caisberger, F; Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K | 1 |
| da Rocha, JB; Dafre, AL; de Bem, AF; dos Santos, AA; dos Santos, DB; Farina, M; Kuca, K; Souza, DO | 1 |
| Bajgar, J; Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Pavlikova, R | 1 |
| Fišar, Z; Hroudová, J; Korábečný, J; Kuča, K; Musílek, K | 1 |
| Iudin, MA; Lantukhov, DV; Vengerovich, NG | 1 |
| Acharya, JR; Ghosh, KK; Gupta, B; Kuca, K; Sharma, R; Singh, N | 1 |
| Antonijevic, B; Antonijevic, E; Djukic-Cosic, D; Kosvancova, A; Kotur-Stevuljevic, J; Kuca, K; Musilek, K; Spasojevic-Kalimanovska, V | 1 |
| Gorecki, L; Jun, D; Korabecny, J; Kuca, K; Kucera, T; Malinak, D; Musilek, K; Soukup, O | 1 |
| Bloch-Shilderman, E; Cohen, L; Egoz, I; Gez, R; Gutman, H; Nili, U; Rabinovitz, I; Yacov, G | 1 |
| Dohnal, V; Dolezal, M; Jun, D; Kuca, K; Musilek, K | 1 |
| Dohnal, V; Dolezal, M; Holas, O; Jun, D; Kuca, K; Musilek, K | 1 |
| Cabal, J; Gunn-Moore, F; Jun, D; Kassa, J; Kuca, K; Musilek, K | 1 |
| Dohnal, V; Jun, D; Kuca, K; Kucera, J; Musilek, K; Opletalova, V | 1 |
| Dohnal, V; Dolezal, M; Gunn-Moore, F; Holas, O; Horova, A; Komloova, M; Kuca, K; Musilek, K; Pohanka, M | 1 |
| Acharya, J; Karade, HN; Kaushik, MP; Valiveti, AK | 1 |
1 review(s) available for obidoxime chloride and trimedoxime bromide
| Article | Year |
|---|---|
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.
Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime | 2007 |
1 trial(s) available for obidoxime chloride and trimedoxime bromide
| Article | Year |
|---|---|
Clinical observation and comparison of the effectiveness of several oxime cholinesterase reactivators.
Topics: Alanine Transaminase; Cholinesterase Reactivators; Cholinesterases; Clinical Trials as Topic; Disulfoton; Erythrocytes; Humans; Insecticides; Obidoxime Chloride; Occupational Diseases; Parathion; Pralidoxime Compounds; Trimedoxime | 1985 |
37 other study(ies) available for obidoxime chloride and trimedoxime bromide
| Article | Year |
|---|---|
[Effect of some reactivators on cholinesterase activity in the chromodacryorrhea test in rats].
Topics: Animals; Cholinesterase Reactivators; Cholinesterases; Dose-Response Relationship, Drug; Enzyme Activation; Female; Injections, Subcutaneous; Insecticides; Obidoxime Chloride; Organophosphorus Compounds; Pralidoxime Compounds; Rats; Tears; Time Factors; Trimedoxime | 1976 |
Antidotal therapy and changes of acetylcholinesterase activity following isopropyl methylphosphonofluoridate intoxication in mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Sarin; Trimedoxime | 1975 |
Efficacy of various pretreatment and therapy regimens against soman lethality in mice.
Topics: Animals; Atropine; Diazepam; Female; Male; Mice; Obidoxime Chloride; Poisoning; Pyridostigmine Bromide; Soman; Trihexyphenidyl; Trimedoxime | 1991 |
Allosteric stabilization of 3H-N-methylscopolamine binding in guinea-pig myocardium by an antidote against organophosphate intoxication.
Topics: Allosteric Regulation; Animals; Antidotes; Binding, Competitive; Female; Guinea Pigs; Heart; In Vitro Techniques; Isoindoles; Male; Myocardium; N-Methylscopolamine; Obidoxime Chloride; Organophosphate Poisoning; Parasympatholytics; Phthalimides; Receptors, Muscarinic; Scopolamine Derivatives; Trimedoxime | 1988 |
Reversible and irreversible inhibition of rat brain muscarinic receptors is related to different substitutions on bisquaternary pyridinium oximes.
Topics: Animals; Benzilates; Binding, Competitive; Brain Stem; Cell-Free System; Obidoxime Chloride; Oximes; Parasympatholytics; Piperidines; Pyridinium Compounds; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Trimedoxime | 1985 |
[Reactivating effect of trimedoxime and obidoxime on cholinesterases inhibited in the heart and intercostal muscles of the rat during acute poisoning with O-ethyl-S-(dimethylaminethyl)-methylthiophosphonate. (A histochemical study)].
Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Heart; Insecticides; Intercostal Muscles; Male; Myocardium; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Rats; Trimedoxime | 1974 |
[Trial of cholinesterase reactivators as proserine antagonists].
Topics: Animals; Antidotes; Atropine; Butanones; Cholinesterase Reactivators; Diphenylacetic Acids; Drug Synergism; Male; Mice; Neostigmine; Obidoxime Chloride; Oximes; Parasympatholytics; Pralidoxime Compounds; Pyridinium Compounds; Trimedoxime | 1983 |
Studies on the entry of cholinesterase reactivators into red blood cells.
Topics: Animals; Cholinesterase Reactivators; Drug Interactions; Erythrocytes; In Vitro Techniques; Male; Obidoxime Chloride; Pralidoxime Compounds; Rats; Trimedoxime | 1983 |
Comparative studies of pralidoxime, trimedoxime, obidoxime and diethyxime in acute fluostigmine poisoning in rats.
Topics: Animals; Antidotes; Cholinesterases; Enzyme Activation; Enzyme Reactivators; Female; Isoflurophate; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Rats; Trimedoxime | 1982 |
A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat.
Topics: Administration, Oral; Animals; Antidotes; Atropine; Diazepam; Dose-Response Relationship, Drug; Insecticides; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Rats; Rats, Wistar; Trimedoxime | 1995 |
[Reactivation and aging of acetylcholinesterase in human brain inhibited by phoxim and phoxim oxon in vitro].
Topics: Acetylcholinesterase; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Stability; Humans; In Vitro Techniques; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Paraoxon; Pralidoxime Compounds; Time Factors; Trimedoxime | 2002 |
Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos.
Topics: Acidosis; Animals; Antidotes; Atropine; Blood Gas Analysis; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dichlorvos; Drug Synergism; Male; Obidoxime Chloride; Rats; Rats, Wistar; Sodium Bicarbonate; Trimedoxime | 2006 |
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2006 |
Pyridinium, imidazolium and quinuclidinium compounds: toxicity and antidotal effects against the nerve agents Tabun and Soman.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Trimedoxime | 2006 |
In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; In Vitro Techniques; Molecular Structure; Obidoxime Chloride; Organophosphates; Rats; Trimedoxime | 2006 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime | 2008 |
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice.
Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime | 2008 |
A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Diaphragm; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2008 |
Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Molecular Structure; Molecular Weight; Obidoxime Chloride; Organophosphates; Oxidative Stress; Pyridinium Compounds; Rats; Rats, Wistar; Toxicity Tests, Acute; Trimedoxime | 2009 |
A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2009 |
Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6.
Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Isoflurophate; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2009 |
A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Trimedoxime | 2010 |
In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Repression; Insecticides; Malathion; Male; Mice; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Trimedoxime | 2010 |
A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2011 |
In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity.
Topics: Animals; Brain; Cholinesterase Reactivators; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Swine; Trimedoxime | 2011 |
[Studying kinetics of oxime-induced reactivation of malathion-inhibited cholinesterase].
Topics: Acetylcholinesterase; Animals; Antidotes; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocytes; Horses; Kinetics; Malathion; Obidoxime Chloride; Pralidoxime Compounds; Solutions; Torpedo; Trimedoxime | 2013 |
In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes.
Topics: Acetylcholinesterase; Alkenes; Animals; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Electrophorus; Isoflurophate; Kinetics; Obidoxime Chloride; Paraoxon; Pyridinium Compounds; Structure-Activity Relationship; Trimedoxime | 2014 |
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain.
Topics: Animals; Aryldialkylphosphatase; Biomarkers; Brain; Cholinesterase Inhibitors; Dichlorvos; Male; Malondialdehyde; Obidoxime Chloride; Organophosphate Poisoning; Oxidative Stress; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Superoxide Dismutase; Trimedoxime | 2018 |
Oxime K203: a drug candidate for the treatment of tabun intoxication.
Topics: Acetylcholinesterase; Antidotes; Molecular Docking Simulation; Nerve Agents; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Trimedoxime | 2019 |
Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats.
Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Administration Schedule; Drug Combinations; Environmental Exposure; Eye Diseases; Male; Obidoxime Chloride; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Trimedoxime | 2019 |
Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Hydrocarbons, Brominated; Nitrogen; Oximes; Pyridinium Compounds; Rats | 2006 |
Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Topics: Cholinesterase Inhibitors; Nitriles; Organophosphates; Paraoxon; Pyridinium Compounds | 2006 |
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Design; Kinetics; Organophosphates; Oximes; Pyridinium Compounds; Structure-Activity Relationship | 2007 |
Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Activators; Models, Biological; Molecular Structure; Organophosphates; Paraoxon; Pyridinium Compounds; Rats; Stereoisomerism; Structure-Activity Relationship | 2008 |
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.
Topics: Acetylcholinesterase; Binding Sites; Catalytic Domain; Cholinesterase Reactivators; Computer Simulation; Humans; Hydrogen Bonding; Organophosphorus Compounds; Oximes; Structure-Activity Relationship | 2011 |
Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).
Topics: Acetamides; Acetylcholinesterase; Enzyme Assays; Humans; Kinetics; Organothiophosphorus Compounds; Oximes; Protein Binding; Pyridines; Sarin | 2014 |