obidoxime chloride has been researched along with tabun in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.20) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 21 (51.22) | 29.6817 |
| 2010's | 12 (29.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goulet, JC; Hand, BT; Lundy, PM | 1 |
| Clement, JG; Gennings, C; Shiloff, JD | 1 |
| Artursson, E; Bucht, G; Puu, G | 1 |
| De Bisschop, HC; Nicaise, M; Willems, JL | 1 |
| Kleine, A; Szinicz, L; Worek, F | 1 |
| Kirchner, T; Szinicz, L; Worek, F | 1 |
| Knopff, O; Szinicz, L; Widmann, R; Worek, F | 1 |
| Kassa, J; Krejcová, G | 2 |
| Kassa, J; Krejèová, G | 1 |
| HEILBRONN, E; TOLAGEN, B | 1 |
| Kassa, J; Kuca, K | 1 |
| Cabal, J; Kassa, J; Kuca, K | 1 |
| Cabal, J; Hrabinova, M; Jun, D; Kassa, J; Kuca, K | 1 |
| Reiner, E; Simeon-Rudolf, V | 1 |
| Akfur, C; Artursson, E; Boman, M; Börjegren, S; Ekström, F; Pang, YP | 1 |
| Cabal, J; Hrabinova, M; Jun, D; Kuca, K | 1 |
| Karasova, J; Kassa, J | 1 |
| Bajgar, J; Jun, D; Kuca, K | 1 |
| Aurbek, N; Becker, C; Eyer, P; Koller, M; Thiermann, H; Worek, F | 1 |
| Cabal, J; Jun, D; Kuca, K; Musilek, K | 1 |
| Jun, D; Kassa, J; Kuca, K | 1 |
| Dohnal, V; Dolezal, M; Holas, O; Jun, D; Kuca, K; Musilek, K | 1 |
| Karasova, J; Kassa, J; Kuca, K; Musilek, K | 1 |
| Humlicek, V; Kassa, J | 1 |
| Jung, YS; Karasova, J; Kassa, J; Kuca, K; Musilek, K | 1 |
| Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Pohanka, M | 1 |
| Bajgar, J; Karasova, J; Kassa, J; Kuca, K; Musilek, K; Vasina, L | 1 |
| Bajgar, J; Karasova, J; Kassa, J; Kopelikova, I; Kuca, K; Musilek, K | 1 |
| Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Misik, J; Pavlikova, R | 1 |
| Aurbek, N; Herkert, NM; Koller, M; Thiermann, H; Worek, F | 1 |
| Caisberger, F; Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K | 1 |
| Karasova, JZ; Kassa, J; Kuca, K; Musilek, K | 1 |
| Bajgar, J; Capek, L; Fusek, J; Hajek, P; Jun, D; Kassa, J; Krs, O; Kuca, K; Paseka, A; Slizova, D; Zdarova, JK | 1 |
| Bajgar, J; Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Pavlikova, R | 1 |
| Baati, R; Gillon, E; Jean, L; Mercey, G; Nachon, F; Renard, PY; Saint-André, G; Verdelet, T; Wagner, A | 1 |
| Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S | 1 |
| Brandhuber, F; Kubik, S; Porwol, L; Reiter, G; Tenberken, O; Thiermann, H; Worek, F; Zengerle, M | 1 |
| Ganguly, B; Lo, R | 1 |
| Koller, M; Thiermann, H; Wille, T; Worek, F | 1 |
| Gorecki, L; Jun, D; Korabecny, J; Kuca, K; Kucera, T; Malinak, D; Musilek, K; Soukup, O | 1 |
41 other study(ies) available for obidoxime chloride and tabun
| Article | Year |
|---|---|
Hormone- and dose schedule-dependent protection by HI-6 against soman and tabun poisoning.
Topics: Animals; Body Weight; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Male; Obidoxime Chloride; Orchiectomy; Organophosphates; Organophosphorus Compounds; Ovariectomy; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Species Specificity; Testosterone; Time Factors | 1989 |
Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Soman | 1987 |
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism | 1986 |
Delayed neuropathy by the organophosphorus nerve agents soman and tabun.
Topics: Animals; Chickens; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Lethal Dose 50; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nervous System Diseases; Pyridinium Compounds; Soman | 1984 |
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning.
Topics: Animals; Atropine; Blood Pressure; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Pyridostigmine Bromide; Respiration | 1995 |
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function.
Topics: Animals; Atropine; Blood Circulation; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiration | 1994 |
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.
Topics: Acetylcholinesterase; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Soman | 1998 |
Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats.
Topics: Animals; Antidotes; Atropine; Behavior, Animal; Benactyzine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Drug Therapy, Combination; Lethal Dose 50; Male; Motor Activity; Nervous System Diseases; Neuroprotective Agents; Neuropsychological Tests; Obidoxime Chloride; Organophosphates; Pyridostigmine Bromide; Rats; Rats, Wistar; Trihexyphenidyl | 2003 |
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar | 2003 |
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONING.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pharmacology; Phosphates; Research; Sarin; Soman; Toxicology | 1965 |
In vitro reactivation of acetylcholinesterase using the oxime K027.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2004 |
Anticholinergic drugs--functional antidotes for the treatment of tabun intoxication.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinergic Antagonists; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Rats; Rats, Wistar | 2004 |
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin | 2004 |
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2006 |
Pyridinium, imidazolium and quinuclidinium compounds: toxicity and antidotal effects against the nerve agents Tabun and Soman.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Trimedoxime | 2006 |
Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Nitrogen; Obidoxime Chloride; Organophosphates; Oximes; Protein Conformation; Pyridinium Compounds | 2006 |
In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; In Vitro Techniques; Molecular Structure; Obidoxime Chloride; Organophosphates; Rats; Trimedoxime | 2006 |
A comparison of the potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats.
Topics: Animals; Antidotes; Atropine; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinergic Antagonists; Dose-Response Relationship, Drug; Injections, Intramuscular; Lacrimal Apparatus; Male; Miosis; Molecular Structure; Muscle Tonus; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tears; Time Factors; Toxicity Tests; Treatment Outcome | 2007 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates.
Topics: Acetylcholinesterase; Aging; Amides; Cholinesterase Reactivators; Humans; Kinetics; Obidoxime Chloride; Organophosphates; Oximes; Phosphoric Acids; Structure-Activity Relationship | 2007 |
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases.
Topics: Acetylcholinesterase; Butanes; Caudate Nucleus; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; In Vitro Techniques; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 2007 |
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats.
Topics: Animals; Antidotes; Brain; Butanes; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Male; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Structure-Activity Relationship | 2007 |
Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Chemistry; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Drug Design; Models, Chemical; Obidoxime Chloride; Organophosphates; Paraoxon; Pesticides; Pyridinium Compounds; Salts; Xylenes | 2007 |
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime | 2008 |
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice.
Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime | 2008 |
A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Diaphragm; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2008 |
Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Molecular Structure; Molecular Weight; Obidoxime Chloride; Organophosphates; Oxidative Stress; Pyridinium Compounds; Rats; Rats, Wistar; Toxicity Tests, Acute; Trimedoxime | 2009 |
A comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Rats; Rats, Wistar | 2009 |
A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2009 |
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar | 2010 |
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; Kinetics; Obidoxime Chloride; Organophosphates; Oximes; Protein Binding; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2010 |
A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Trimedoxime | 2010 |
A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice.
Topics: Acetylcholinesterase; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar | 2010 |
A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Frontal Lobe; GPI-Linked Proteins; Lethal Dose 50; Obidoxime Chloride; Organ Specificity; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Reticular Formation | 2010 |
A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2011 |
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Erythrocytes; Humans; Molecular Structure; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridines; Pyridinium Compounds; Soman | 2011 |
A comparison of neuroprotective efficacy of the oxime K203 and its fluorinated analogue (KR-22836) with obidoxime in Tabun-poisoned rats.
Topics: Acute Disease; Animals; Autonomic Nervous System; Behavior, Animal; Chemical Warfare Agents; Hyperkinesis; Male; Molecular Structure; Muscle Tonus; Neuroprotective Agents; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Treatment Outcome | 2010 |
Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups.
Topics: beta-Cyclodextrins; Chemical Warfare Agents; Cholinesterase Inhibitors; Gas Chromatography-Mass Spectrometry; Glucose; Humans; Hydrogen-Ion Concentration; Inactivation, Metabolic; Molecular Structure; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds | 2012 |
Can hydroxylamine be a more potent nucleophile for the reactivation of tabun-inhibited AChE than prototype oxime drugs? An answer derived from quantum chemical and steered molecular dynamics studies.
Topics: Acetylcholinesterase; Antidotes; Blood-Brain Barrier; Catalytic Domain; Cholinesterase Inhibitors; Drug Design; Hydroxylamine; Kinetics; Molecular Dynamics Simulation; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes | 2014 |
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.
Topics: Acetylcholinesterase; Cholinesterase Reactivators; Drug Therapy, Combination; Humans; Inhalation Exposure; Injections, Intramuscular; Models, Biological; Nerve Agents; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Toxicokinetics | 2016 |
Oxime K203: a drug candidate for the treatment of tabun intoxication.
Topics: Acetylcholinesterase; Antidotes; Molecular Docking Simulation; Nerve Agents; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Trimedoxime | 2019 |