Page last updated: 2024-08-18

obidoxime chloride and sarin

obidoxime chloride has been researched along with sarin in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (19.44)	18.7374
1990's	4 (11.11)	18.2507
2000's	15 (41.67)	29.6817
2010's	10 (27.78)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fonnum, F; Lund-Karlsen, R	1
Bajgar, J; Hrdina, V; Jakl, A; Patocka, J	1
Alioth-Streichenberg, CM; Hofmann, W; Hopff, WH; Niederhauser, A; Portmann, R; Waser, PG	1
Alioth-Streichenberg, CM; Bodmer, DM; Waser, PG	1
Clement, JG; Shiloff, JD	1
Artursson, E; Bucht, G; Puu, G	1
Hopff, WH; Riggio, G; Waser, PG	1
Caratsch, CG; Waser, PG	1
Busker, RW; Melchers, BP; van der Wiel, HJ; van Helden, HP; Zijlstra, JJ	1
Bajgar, J; Kassa, J	1
Eyer, P; Kiderlen, D; Szinicz, L; Thiermann, H; Worek, F	1
Eyer, P; Reiter, G; Szinicz, L; Worek, F	1
HEILBRONN, E; TOLAGEN, B	1
Kassa, J; Kuca, K	1
Cabal, J; Kassa, J; Kuca, K	2
Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F	1
Bajgar, J; Jun, D; Kuca, K	1
Antonijevic, B; Stojiljkovic, MP	1
Bumm, R; Eckert, S; Eyer, P; Herkert, N; Thiermann, H; Weber, G; Worek, F	1
Acharya, J; Dubey, DK; Gupta, AK; Mazumder, A	1
Jun, D; Kuca, K	1
Jun, D; Koleckar, V; Kuca, K; Marek, J; Picha, J	1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F	1
Aurbek, N; Herkert, NM; Koller, M; Thiermann, H; Worek, F	2
Acharya, J; Dubey, DK; Raza, SK	1
Karasova, JZ; Kassa, J; Misik, J	1
Brecht, KM; Maxwell, DM; Sweeney, RE	1
Horova, A; Kassa, J; Matouskova, L; Musilek, K; Sepsova, V	1
Koller, M; Thiermann, H; Wille, T; Worek, F	1
Chen, J; Guo, L; Tang, J; Xie, J; Xie, Y; Xu, B; Yan, L	1
Acharya, BN; Acharya, J; Bhalerao, U; Karade, HN; Raviraju, G; Valiveti, AK	1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL	1
Cochrane, L; Cornelissen, AS; Joosen, MJA; Klaassen, SD; Shearer, JD; Skiadopoulos, MH; van Groningen, T; Verheij, E	1
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A	1

Reviews

1 review(s) available for obidoxime chloride and sarin

Article	Year
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning. Clinical medicine & research, 2007, Volume: 5, Issue:1 Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime	2007

Article

Year

Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.

Clinical medicine & research, 2007, Volume: 5, Issue:1

Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime

2007

Other Studies

35 other study(ies) available for obidoxime chloride and sarin

Article	Year
The effect of locally applied cholinesterase inhibitors and oximes on the acetylcholinesterase activity in different parts of the guinea-pig eye. Acta pharmacologica et toxicologica, 1976, Volume: 38, Issue:4 Topics: Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Eye; Guinea Pigs; Isoflurophate; Obidoxime Chloride; Oculomotor Muscles; Oximes; Paraoxon; Sarin	1976
Antidotal therapy and changes of acetylcholinesterase activity following isopropyl methylphosphonofluoridate intoxication in mice. Acta biologica et medica Germanica, 1975, Volume: 34, Issue:6 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Sarin; Trimedoxime	1975
Interaction of obidoxime with sarin in aqueous solution. Archives of toxicology, 1992, Volume: 66, Issue:3 Topics: Chromatography, Thin Layer; Drug Interactions; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Obidoxime Chloride; Phosphorus; Sarin; Solutions; Spectrophotometry, Ultraviolet	1992
Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats. Toxicology and applied pharmacology, 1991, Volume: 108, Issue:3 Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Female; Obidoxime Chloride; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Sarin	1991
Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats. Toxicology and applied pharmacology, 1987, Jun-30, Volume: 89, Issue:2 Topics: Acetylcholinesterase; Animals; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin	1987
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime. Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9 Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism	1986
Sarin poisoning in guinea pigs compared to reactivation of acetylcholinesterase in vitro as a basis for therapy. Acta pharmacologica et toxicologica, 1984, Volume: 55, Issue:1 Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Female; Guinea Pigs; In Vitro Techniques; Lethal Dose 50; Male; Obidoxime Chloride; Organophosphate Poisoning; Sarin; Species Specificity	1984
Effects of obidoxime chloride on native and sarin-poisoned frog neuromuscular junctions. Pflugers Archiv : European journal of physiology, 1984, Volume: 401, Issue:1 Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Reactivators; Iontophoresis; Membrane Potentials; Motor Endplate; Neuromuscular Junction; Obidoxime Chloride; Oximes; Rana temporaria; Receptors, Cholinergic; Sarin; Sodium Chloride	1984
Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats. Archives of toxicology, 1994, Volume: 68, Issue:4 Topics: Animals; Binding, Competitive; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Oximes; Pyridines; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Sarin; Synaptic Transmission	1994
Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice. Acta medica (Hradec Kralove), 1996, Volume: 39, Issue:1 Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Gas Poisoning; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman	1996
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase. Archives of toxicology, 2000, Volume: 74, Issue:1 Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Aging; Erythrocytes; Humans; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Sarin	2000
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Archives of toxicology, 2002, Volume: 76, Issue:9 Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity	2002
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONING. Biochemical pharmacology, 1965, Jan-01, Volume: 14 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pharmacology; Phosphates; Research; Sarin; Soman; Toxicology	1965
In vitro reactivation of acetylcholinesterase using the oxime K027. Veterinary and human toxicology, 2004, Volume: 46, Issue:1 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship	2004
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods. Die Pharmazie, 2004, Volume: 59, Issue:10 Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin	2004
In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes. Journal of enzyme inhibition and medicinal chemistry, 2005, Volume: 20, Issue:3 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Species Specificity; Structure-Activity Relationship; Swine	2005
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro. Archives of toxicology, 2007, Volume: 81, Issue:6 Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet	2007
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro. Drug and chemical toxicology, 2007, Volume: 30, Issue:1 Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime	2007
Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity. Biochemical pharmacology, 2008, Feb-01, Volume: 75, Issue:3 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Muscles; Obidoxime Chloride; Paraoxon; Perfusion; Sarin	2008
In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages. Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:2 Topics: Acetylcholinesterase; Animals; Chemical Phenomena; Chemistry, Physical; Cholinesterase Inhibitors; Cholinesterase Reactivators; Electrophorus; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Quantitative Structure-Activity Relationship; Sarin	2008
Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2006, Volume: 2, Issue:4 Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Research Design; Sarin; Swine	2006
Potency of novel oximes to reactivate sarin inhibited human cholinesterases. Drug and chemical toxicology, 2008, Volume: 31, Issue:1 Topics: Acetylcholinesterase; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; In Vitro Techniques; Molecular Structure; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship	2008
A structure-activity analysis of the variation in oxime efficacy against nerve agents. Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2 Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship	2008
Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study. Toxicology letters, 2009, Jun-01, Volume: 187, Issue:2 Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin	2009
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship? Chemico-biological interactions, 2010, Sep-06, Volume: 187, Issue:1-3 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; Kinetics; Obidoxime Chloride; Organophosphates; Oximes; Protein Binding; Pyridinium Compounds; Sarin; Structure-Activity Relationship	2010
In vitro evaluation of bis-pyridinium oximes bearing methoxy alkane linker as reactivators of sarin inhibited human acetylcholinesterase. Toxicology in vitro : an international journal published in association with BIBRA, 2010, Volume: 24, Issue:6 Topics: Adult; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; In Vitro Techniques; Male; Obidoxime Chloride; Pralidoxime Compounds; Sarin	2010
A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats. Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:5 Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Czech Republic; Drug Therapy, Combination; Lethal Dose 50; Male; Muscarinic Antagonists; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Psychomotor Performance; Pyridinium Compounds; Rats; Rats, Wistar; Sarin	2012
A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; GPI-Linked Proteins; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Quantitative Structure-Activity Relationship; Recombinant Proteins; Sarin	2013
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice. Toxicology mechanisms and methods, 2015, Volume: 25, Issue:3 Topics: Acetylcholinesterase; Animals; Animals, Outbred Strains; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats, Wistar; Sarin	2015
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. Toxicology, 2016, 03-28, Volume: 350-352 Topics: Acetylcholinesterase; Cholinesterase Reactivators; Drug Therapy, Combination; Humans; Inhalation Exposure; Injections, Intramuscular; Models, Biological; Nerve Agents; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Toxicokinetics	2016
A liquid chromatography tandem mass spectrometric method on in vitro nerve agents poisoning characterization and reactivator efficacy evaluation by determination of specific peptide adducts in acetylcholinesterase. Journal of chromatography. A, 2016, Jun-10, Volume: 1450 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, Liquid; Colorimetry; Enzyme Activation; Humans; In Vitro Techniques; Nerve Agents; Obidoxime Chloride; Oximes; Peptide Fragments; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Tandem Mass Spectrometry	2016
Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE). Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18 Topics: Acetamides; Aminopyridines; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Niacinamide; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin	2016
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice. Toxicology, 2018, 09-01, Volume: 408 Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors	2018
Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs. Chemico-biological interactions, 2018, Dec-25, Volume: 296 Topics: Animals; Atropine; Cholinesterase Reactivators; Cholinesterases; Dose-Response Relationship, Drug; Drug Compounding; Electroencephalography; Guinea Pigs; Injections, Subcutaneous; Male; Obidoxime Chloride; Sarin; Structure-Activity Relationship; Survival Rate	2018
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine	2008