Compounds > obidoxime chloride
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obidoxime chloride and pralidoxime

obidoxime chloride has been researched along with pralidoxime in 62 studies

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-19906 (9.68)18.7374
1990's8 (12.90)18.2507
2000's27 (43.55)29.6817
2010's19 (30.65)24.3611
2020's2 (3.23)2.80

Authors

AuthorsStudies
Clement, JG1
Busker, RW; de Lange, J; Melchers, BP; van Helden, HP1
Hänninen, O; Kaliste-Korhonen, E; Ryhänen, R; Ylitalo, P1
Clement, JG; Shiloff, JD1
Chowdhri, BL; Das Gupta, S; Ghosh, AK; Moorthy, MV1
Abrego-Moya, V; Menchaca-Marines, MC; Quiroga-Garza, A1
Chowdhri, BL; Das Gupta, S; Ghosh, AK; Jaiswal, DK; Moorthy, MV; Pant, BP1
Almog, S; Lifshitz, M; Rotenberg, M; Shahak, E; Sofer, S; Tamiri, T1
Jokanović, M; Maksimović, M1
Bäcker, M; Eyer, P; Klimmek, R; Mast, U; Szinicz, L; Thiermann, H; Worek, F1
Knopff, O; Szinicz, L; Widmann, R; Worek, F1
Diepold, C; Eyer, P; Worek, F1
Ashani, Y; Doctor, BP; Leader, H; Luo, C; Radić, Z; Saxena, A; Taylor, P1
Eyer, P; Kiderlen, D; Szinicz, L; Thiermann, H; Worek, F1
Eyer, P; Reiter, G; Szinicz, L; Worek, F1
Du, X; Li, J; Sun, M; Zhang, Y1
Kassa, J; Krejèová, G1
JAQUES, R1
Szinicz, L; Thiermann, H; Worek, F1
Kassa, J; Kuca, K1
Cabal, J; Kassa, J; Kuca, K2
Abdi, M; Abdollahi, M; Pajoumand, A; Rezaie, A; Shadnia, S1
Aas, P; Tansø, R; Øydvin, OK1
Cabal, J; Hrabinová, M; Jun, D; Kassa, J; Kuca, K2
Graham, P; Moran, JL; Peter, JV1
Brecht, KM; Koplovitz, I; Maxwell, DM; Sweeney, RE1
Eyer, P; Worek, F1
Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F1
Bajgar, J; Jun, D; Kuca, K1
Cabal, J; Jun, D; Kuca, K; Musilek, K1
Antonijevic, B; Stojiljkovic, MP1
Acharya, J; Dubey, DK; Gupta, AK; Mazumder, A1
Jun, D; Kuca, K1
Jun, D; Koleckar, V; Kuca, K; Marek, J; Picha, J1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
Hasan, MY; Kuca, K; Lorke, DE; Musilek, K; Nurulain, SM; Petroianu, GA1
Jun, D; Kuca, K; Pohanka, M1
Aurbek, N; Eyer, F; Eyer, P; Thiermann, H; Worek, F1
Hasan, MY; Kuca, K; Lorke, DE; Nurulain, SM; Petroianu, GA; Schmitt, A1
Capowiez, Y; Collange, B; Mazzia, C; Rault, M; Sanchez-Hernandez, JC; Wheelock, CE1
Eyer, P; Thiermann, H; Worek, F1
da Rocha, JB; Dafre, AL; de Bem, AF; dos Santos, AA; dos Santos, DB; Farina, M; Kuca, K; Souza, DO1
Acharya, J; Dubey, DK; Raza, SK1
Aurbek, N; Eyer, P; Thiermann, H; Wille, T; Worek, F1
Fišar, Z; Hroudová, J; Korábečný, J; Kuča, K; Musílek, K1
Hrabinova, M; Kuca, K; Pohanka, M; Simonato, JP1
Barcelos, RP; Bresolin, L; Bueno, DC; Carratu, VS; da Rocha, JB; de Aquino Saraiva, R; de Vargas Barbosa, NB; Gubert, P; Lugokenski, TH; Nogara, PA; Pereira, ME; Soares, FA1
Arboléas, M; Baati, R; Gillon, E; Jean, L; Kliachyna, M; Loiodice, M; Mercey, G; Nachon, F; Păunescu, E; Renard, PY; Renou, J; Verdelet, T1
Iudin, MA; Lantukhov, DV; Vengerovich, NG1
Kaltenbach, L; Thiermann, H; Wille, T; Worek, F1
Elsinghorst, P; Koller, M; Thiermann, H; Worek, F1
Appu, AP; Arun, P; Baskota, S; Braga, MFM; Dagata, J; Farkas, N; Figueiredo, TH; Frey, WH; Krishnan, JKS; Moffett, JR; Namboodiri, AMA; Olsen, CH; Vijayakumar, N1
Chen, J; Guo, L; Tang, J; Xie, J; Xie, Y; Xu, B; Yan, L1
Babin, MC; Jett, DA; Platoff, GE; Snider, TH; Yeung, DT1
Acharya, BN; Acharya, J; Bhalerao, U; Karade, HN; Raviraju, G; Valiveti, AK1
Antonijevic, B; Antonijevic, E; Djukic-Cosic, D; Kosvancova, A; Kotur-Stevuljevic, J; Kuca, K; Musilek, K; Spasojevic-Kalimanovska, V1
Celmar Costa França, T; da Silva, JAV; Kuca, K; Nepovimova, E; Ramalho, TC1
Hasan, MY; Kuča, K; Lorke, DE; Nurulain, SM; Petroianu, GA1
John, H; Kranawetvogl, T; Steinritz, D; Thiermann, H1
Thiermann, H; Worek, F1

Reviews

3 review(s) available for obidoxime chloride and pralidoxime

ArticleYear
Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.
    Chemico-biological interactions, 1999, May-14, Volume: 119-120

    Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Edrophonium; Kinetics; Mice; Obidoxime Chloride; Oximes; Phosphorylation; Pralidoxime Compounds; Pyridinium Compounds

1999
Oxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques.
    Critical care medicine, 2006, Volume: 34, Issue:2

    Topics: Adult; Cholinesterase Reactivators; Clinical Trials as Topic; Female; Humans; Insecticides; Male; Mortality; Obidoxime Chloride; Organophosphate Poisoning; Pralidoxime Compounds; Respiration, Artificial; Treatment Outcome

2006
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.
    Clinical medicine & research, 2007, Volume: 5, Issue:1

    Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime

2007

Trials

1 trial(s) available for obidoxime chloride and pralidoxime

ArticleYear
Benefits of magnesium sulfate in the management of acute human poisoning by organophosphorus insecticides.
    Human & experimental toxicology, 2004, Volume: 23, Issue:12

    Topics: Adolescent; Adult; Aged; Atropine; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Humans; Insecticides; Magnesium Sulfate; Male; Middle Aged; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Pralidoxime Compounds; Single-Blind Method

2004

Other Studies

58 other study(ies) available for obidoxime chloride and pralidoxime

ArticleYear
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.
    Archives of toxicology, 1992, Volume: 66, Issue:2

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds

1992
Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.
    Archives of toxicology, 1991, Volume: 65, Issue:7

    Topics: Animals; Antidotes; Blood-Brain Barrier; Cholinesterase Reactivators; Diaphragm; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Respiratory Insufficiency; Synaptic Transmission

1991
Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice.
    General pharmacology, 1989, Volume: 20, Issue:6

    Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Cholinesterase Reactivators; Cold Temperature; Enzyme Reactivators; Isoflurophate; Lethal Dose 50; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Rats; Rats, Inbred F344

1989
Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats.
    Toxicology and applied pharmacology, 1987, Jun-30, Volume: 89, Issue:2

    Topics: Acetylcholinesterase; Animals; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin

1987
Studies on the entry of cholinesterase reactivators into red blood cells.
    Die Pharmazie, 1983, Volume: 38, Issue:11

    Topics: Animals; Cholinesterase Reactivators; Drug Interactions; Erythrocytes; In Vitro Techniques; Male; Obidoxime Chloride; Pralidoxime Compounds; Rats; Trimedoxime

1983
[Poisoning by organophosphorus insecticides. Report of 2 cases].
    Boletin medico del Hospital Infantil de Mexico, 1984, Volume: 41, Issue:7

    Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Humans; Infant; Malathion; Male; Obidoxime Chloride; Parathion; Pralidoxime Compounds

1984
Comparative studies of pralidoxime, trimedoxime, obidoxime and diethyxime in acute fluostigmine poisoning in rats.
    Die Pharmazie, 1982, Volume: 37, Issue:8

    Topics: Animals; Antidotes; Cholinesterases; Enzyme Activation; Enzyme Reactivators; Female; Isoflurophate; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Rats; Trimedoxime

1982
Carbamate poisoning and oxime treatment in children: a clinical and laboratory study.
    Pediatrics, 1994, Volume: 93, Issue:4

    Topics: Aldicarb; Antidotes; Atropine; Carbamates; Child; Child, Preschool; Cholinesterases; Drug Therapy, Combination; Female; Humans; Infant; Male; Methomyl; Obidoxime Chloride; Oximes; Paraoxon; Poisoning; Pralidoxime Compounds; Retrospective Studies

1994
A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat.
    Archives of toxicology, 1995, Volume: 70, Issue:2

    Topics: Administration, Oral; Animals; Antidotes; Atropine; Diazepam; Dose-Response Relationship, Drug; Insecticides; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Rats; Rats, Wistar; Trimedoxime

1995
Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning.
    Human & experimental toxicology, 1997, Volume: 16, Issue:8

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Poisoning; Pralidoxime Compounds

1997
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.
    Archives of toxicology, 1998, Volume: 72, Issue:4

    Topics: Acetylcholinesterase; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Soman

1998
Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics.
    Archives of toxicology, 1999, Volume: 73, Issue:1

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Humans; Insecticides; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Paraoxon; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Time Factors

1999
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase.
    Archives of toxicology, 2000, Volume: 74, Issue:1

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Aging; Erythrocytes; Humans; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Sarin

2000
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
    Archives of toxicology, 2002, Volume: 76, Issue:9

    Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity

2002
[Reactivation and aging of acetylcholinesterase in human brain inhibited by phoxim and phoxim oxon in vitro].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2002, Volume: 36, Issue:5

    Topics: Acetylcholinesterase; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Stability; Humans; In Vitro Techniques; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Paraoxon; Pralidoxime Compounds; Time Factors; Trimedoxime

2002
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.
    Pharmacology & toxicology, 2003, Volume: 92, Issue:6

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar

2003
THE PROTECTIVE EFFECT OF PYRIDINE-2-ALDOXIME METHIODIDE (P2AM), BIS-(4-HYDROXYIMINO-METHYL-PYRIDINIUM-1-METHYL)-ETHER DICHLORIDE (TOXOGONIN) AND ATROPINE IN EXPERIMENTAL DDVP POISONING.
    Helvetica physiologica et pharmacologica acta, 1964, Volume: 22

    Topics: Animals; Antidotes; Atropine; Blood; Brain; Cholinesterase Inhibitors; Cholinesterases; Dichlorvos; Ethers; Horses; Insecticides; Mice; Obidoxime Chloride; Phosphates; Pralidoxime Compounds; Pyridines; Rats; Research; Succinylcholine; Toxicology

1964
Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines.
    Archives of toxicology, 2004, Volume: 78, Issue:4

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Phosphorylcholine; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Spectrophotometry; Time Factors

2004
In vitro reactivation of acetylcholinesterase using the oxime K027.
    Veterinary and human toxicology, 2004, Volume: 46, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2004
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
    Die Pharmazie, 2004, Volume: 59, Issue:10

    Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2004
Pre-junctional effects of oximes on [3H]-acetylcholine release in rat hippocampal slices during soman intoxication.
    European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Oximes; Potassium; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tritium

2005
In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes.
    Journal of enzyme inhibition and medicinal chemistry, 2005, Volume: 20, Issue:3

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Species Specificity; Structure-Activity Relationship; Swine

2005
A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
    Acta medica (Hradec Kralove), 2005, Volume: 48, Issue:2

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; In Vitro Techniques; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar

2005
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
    Journal of toxicology and environmental health. Part A, 2006, Volume: 69, Issue:15

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2006
Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds?
    Archives of toxicology, 2006, Volume: 80, Issue:11

    Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Guinea Pigs; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Models, Biological; Obidoxime Chloride; Organophosphorus Compounds; Pralidoxime Compounds; Rabbits; Rats; Rats, Sprague-Dawley

2006
The liberation of thiocholine from acetylthiocholine (ASCh) by pralidoxime iodide (2=PAM) and other oximes (obidoxime and diacetylmonoxime).
    Toxicology letters, 2006, Dec-15, Volume: 167, Issue:3

    Topics: Acetylcholinesterase; Acetylthiocholine; Diacetyl; Obidoxime Chloride; Pralidoxime Compounds; Thiocholine

2006
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
    Archives of toxicology, 2007, Volume: 81, Issue:6

    Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet

2007
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:1

    Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime

2007
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases.
    Neurotoxicity research, 2007, Volume: 11, Issue:2

    Topics: Acetylcholinesterase; Butanes; Caudate Nucleus; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; In Vitro Techniques; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds

2007
In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages.
    Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:2

    Topics: Acetylcholinesterase; Animals; Chemical Phenomena; Chemistry, Physical; Cholinesterase Inhibitors; Cholinesterase Reactivators; Electrophorus; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Quantitative Structure-Activity Relationship; Sarin

2008
Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2006, Volume: 2, Issue:4

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Research Design; Sarin; Swine

2006
Potency of novel oximes to reactivate sarin inhibited human cholinesterases.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:1

    Topics: Acetylcholinesterase; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; In Vitro Techniques; Molecular Structure; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity.
    Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:7

    Topics: Animals; Antidotes; Cholinesterase Inhibitors; Drug Antagonism; Injections, Intraperitoneal; Isoflurophate; Lethal Dose 50; Longevity; Obidoxime Chloride; Pralidoxime Compounds; Rats; Rats, Wistar; Structure-Activity Relationship

2008
In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048.
    Journal of enzyme inhibition and medicinal chemistry, 2009, Volume: 24, Issue:3

    Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Trichlorfon

2009
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
    Toxicology, 2009, May-17, Volume: 259, Issue:3

    Topics: Acetylcholinesterase; Biomarkers; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds

2009
Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6.
    Toxicology mechanisms and methods, 2009, Volume: 19, Issue:4

    Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Isoflurophate; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2009
Inhibition, recovery and oxime-induced reactivation of muscle esterases following chlorpyrifos exposure in the earthworm Lumbricus terrestris.
    Environmental pollution (Barking, Essex : 1987), 2010, Volume: 158, Issue:6

    Topics: Animals; Biomarkers; Carboxylesterase; Chlorpyrifos; Cholinesterase Reactivators; Cholinesterases; Dose-Response Relationship, Drug; Environmental Monitoring; Esterases; Muscles; Obidoxime Chloride; Oligochaeta; Oximes; Pralidoxime Compounds; Soil Pollutants

2010
Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro.
    Toxicology, 2010, Jun-04, Volume: 272, Issue:1-3

    Topics: Acetylcholinesterase; Animals; Diaphragm; Humans; Male; Mice; Mice, Inbred Strains; Obidoxime Chloride; Oximes; Paraoxon; Physical Phenomena; Pralidoxime Compounds; Pyridinium Compounds

2010
In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Repression; Insecticides; Malathion; Male; Mice; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Trimedoxime

2010
In vitro evaluation of bis-pyridinium oximes bearing methoxy alkane linker as reactivators of sarin inhibited human acetylcholinesterase.
    Toxicology in vitro : an international journal published in association with BIBRA, 2010, Volume: 24, Issue:6

    Topics: Adult; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; In Vitro Techniques; Male; Obidoxime Chloride; Pralidoxime Compounds; Sarin

2010
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.
    Toxicology letters, 2011, Jan-15, Volume: 200, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Drug Interactions; Enzyme Reactivators; Guinea Pigs; Humans; Kinetics; Macaca mulatta; Obidoxime Chloride; Oximes; Paraoxon; Pralidoxime Compounds; Pyridinium Compounds; Rabbits; Rats; Rats, Wistar; Species Specificity; Swine

2011
In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity.
    Toxicology letters, 2011, Mar-05, Volume: 201, Issue:2

    Topics: Animals; Brain; Cholinesterase Reactivators; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Swine; Trimedoxime

2011
Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method.
    International journal of molecular sciences, 2011, Volume: 12, Issue:4

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dithionitrobenzoic Acid; Enzyme Assays; Indoles; Kinetics; Obidoxime Chloride; Oximes; Paraoxon; Pralidoxime Compounds; Pyridinium Compounds; Substrate Specificity

2011
Effect of different oximes on rat and human cholinesterases inhibited by methamidophos: a comparative in vitro and in silico study.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:6

    Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Insecticides; Male; Obidoxime Chloride; Organothiophosphorus Compounds; Pralidoxime Compounds; Rats; Rats, Wistar

2012
Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Electrochemistry; GPI-Linked Proteins; Humans; Molecular Structure; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Recombinant Proteins

2013
[Studying kinetics of oxime-induced reactivation of malathion-inhibited cholinesterase].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:1

    Topics: Acetylcholinesterase; Animals; Antidotes; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocytes; Horses; Kinetics; Malathion; Obidoxime Chloride; Pralidoxime Compounds; Solutions; Torpedo; Trimedoxime

2013
Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates.
    Chemico-biological interactions, 2013, Dec-05, Volume: 206, Issue:3

    Topics: Acetylcholinesterase; Animals; Carbamates; Carbaryl; Cholinesterase Inhibitors; Drug Interactions; Humans; Kinetics; Obidoxime Chloride; Oximes; Pesticides; Pralidoxime Compounds; Propoxur

2013
Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications.
    Toxicology letters, 2014, Nov-18, Volume: 231, Issue:1

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; GPI-Linked Proteins; Humans; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Time Factors

2014
Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning.
    Neurotoxicology, 2016, Volume: 53

    Topics: Acetylcholinesterase; Administration, Intranasal; Animals; Biological Availability; Brain; Central Nervous System Diseases; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Male; Obidoxime Chloride; Organophosphate Poisoning; Pralidoxime Compounds; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tritium

2016
A liquid chromatography tandem mass spectrometric method on in vitro nerve agents poisoning characterization and reactivator efficacy evaluation by determination of specific peptide adducts in acetylcholinesterase.
    Journal of chromatography. A, 2016, Jun-10, Volume: 1450

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, Liquid; Colorimetry; Enzyme Activation; Humans; In Vitro Techniques; Nerve Agents; Obidoxime Chloride; Oximes; Peptide Fragments; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Tandem Mass Spectrometry

2016
Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds; Time Factors

2016
Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).
    Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18

    Topics: Acetamides; Aminopyridines; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Niacinamide; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin

2016
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain.
    Archives of toxicology, 2018, Volume: 92, Issue:2

    Topics: Animals; Aryldialkylphosphatase; Biomarkers; Brain; Cholinesterase Inhibitors; Dichlorvos; Male; Malondialdehyde; Obidoxime Chloride; Organophosphate Poisoning; Oxidative Stress; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Superoxide Dismutase; Trimedoxime

2018
Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach.
    Journal of enzyme inhibition and medicinal chemistry, 2019, Volume: 34, Issue:1

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Structure-Activity Relationship

2019
Oximes as pretreatment before acute exposure to paraoxon.
    Journal of applied toxicology : JAT, 2019, Volume: 39, Issue:11

    Topics: Animals; Cholinesterase Reactivators; Lethal Dose 50; Male; Obidoxime Chloride; Paraoxon; Pralidoxime Compounds; Proportional Hazards Models; Protective Agents; Rats, Wistar; Survival Analysis

2019
A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.
    Drug testing and analysis, 2020, Volume: 12, Issue:7

    Topics: Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Humans; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Reproducibility of Results

2020
Pro: Oximes should be used routinely in organophosphate poisoning.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:12

    Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Obidoxime Chloride; Organophosphate Poisoning; Oximes

2022