Compounds > obidoxime chloride
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obidoxime chloride and asoxime chloride

obidoxime chloride has been researched along with asoxime chloride in 108 studies

Research

Studies (108)

TimeframeStudies, this research(%)All Research%
pre-199011 (10.19)18.7374
1990's24 (22.22)18.2507
2000's41 (37.96)29.6817
2010's29 (26.85)24.3611
2020's3 (2.78)2.80

Authors

AuthorsStudies
Clement, JG2
Busker, RW; de Lange, J; Melchers, BP; van Helden, HP1
Goulet, JC; Hand, BT; Lundy, PM1
Clement, JG; Shiloff, JD1
Clement, JG; Gennings, C; Shiloff, JD1
Artursson, E; Bucht, G; Puu, G1
Kloog, Y; Sokolovsky, M1
Balderman, D; Galron, R; Kloog, Y; Sokolovsky, M1
De Bisschop, HC; Nicaise, M; Willems, JL1
Ardab'eva, TV; Khramova, EA; Prozorovskiĭ, VB1
Kleine, A; Szinicz, L; Worek, F1
Kassa, J5
Clement, JG; Erhardt, N1
Busker, RW; Melchers, BP; van der Wiel, HJ; van Helden, HP; Zijlstra, JJ1
Kirchner, T; Szinicz, L; Worek, F1
Aas, P; Fonnum, F; Haider, T; Walday, P1
Bajgar, J; Kassa, J5
Aas, P1
Bielavský, J; Kassa, J1
Knopff, O; Szinicz, L; Widmann, R; Worek, F1
Diepold, C; Eyer, P; Worek, F1
Ashani, Y; Doctor, BP; Leader, H; Luo, C; Radić, Z; Saxena, A; Taylor, P1
Doctor, BP; Garcia, G; Luo, C; Radić, Z; Saxena, A; Smith, M; Taylor, P1
Eyer, P; Kiderlen, D; Szinicz, L; Thiermann, H; Worek, F1
Eyer, P; Reiter, G; Szinicz, L; Worek, F1
Kassa, J; Krejèová, G1
Szinicz, L; Thiermann, H; Worek, F1
Kassa, J; Kuca, K1
Cabal, J; Kassa, J; Kuca, K2
Aas, P; Tansø, R; Øydvin, OK1
Cabal, J; Hrabinová, M; Jun, D; Kassa, J; Kuca, K2
Bartosová, L; Kuca, K; Kunesová, G1
Reiner, E; Simeon-Rudolf, V1
Akfur, C; Artursson, E; Boman, M; Börjegren, S; Ekström, F; Pang, YP1
Karasova, J; Kassa, J2
Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F1
Bajgar, J; Jun, D; Kuca, K1
Cabal, J; Jun, D; Kuca, K; Musilek, K1
Jun, D; Kassa, J; Kuca, K1
Karasova, J; Kassa, J; Kuca, K; Musilek, K1
Jun, D; Kuca, K1
Jun, D; Koleckar, V; Kuca, K; Marek, J; Picha, J1
Humlicek, V; Kassa, J1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
Jung, YS; Karasova, J; Kassa, J; Kuca, K; Musilek, K1
Bajgar, J; Karasova, J; Kassa, J; Kuca, K; Musilek, K1
Bajgar, J; Jun, D; Kassa, J; Kuca, K; Osterreicher, J; Pejchal, J1
Jun, D; Kuca, K; Pohanka, M1
Bajgar, J; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S1
Aurbek, N; Eyer, F; Eyer, P; Thiermann, H; Worek, F1
Aurbek, N; Herkert, NM; Koller, M; Thiermann, H; Worek, F2
Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Misik, J; Pavlikova, R1
Hasan, MY; Kuca, K; Lorke, DE; Nurulain, SM; Petroianu, GA; Schmitt, A1
Antos, K; Kuca, K; Novotny, L; Zdarova Karasova, J; Zivna, H1
Caisberger, F; Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K1
Eyer, P; Thiermann, H; Worek, F1
Karasova, JZ; Kassa, J; Kuca, K; Musilek, K1
Aurbek, N; Eyer, P; Thiermann, H; Wille, T; Worek, F1
Bajgar, J; Capek, L; Fusek, J; Hajek, P; Jun, D; Kassa, J; Krs, O; Kuca, K; Paseka, A; Slizova, D; Zdarova, JK1
Bajgar, J; Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Pavlikova, R1
Fišar, Z; Hroudová, J; Korábečný, J; Kuča, K; Musílek, K1
Baati, R; Gillon, E; Jean, L; Mercey, G; Nachon, F; Renard, PY; Saint-André, G; Verdelet, T; Wagner, A1
Fusek, J; Jun, D; Kaniaková, M; Krůšek, J; Kuča, K; Kumar, UK; Oz, M; Soukup, O; Tobin, G1
Hrabinova, M; Kuca, K; Pohanka, M; Simonato, JP1
Antonijević, B; Bokonjić, D; Stojiljković, MP; Vucinić, S1
Karasova, JZ; Kassa, J; Misik, J1
Brecht, KM; Maxwell, DM; Sweeney, RE1
Arboléas, M; Baati, R; Gillon, E; Jean, L; Kliachyna, M; Loiodice, M; Mercey, G; Nachon, F; Păunescu, E; Renard, PY; Renou, J; Verdelet, T1
Elsinghorst, P; Koller, M; Thiermann, H; Worek, F1
Horova, A; Kassa, J; Matouskova, L; Musilek, K; Sepsova, V1
Koller, M; Thiermann, H; Wille, T; Worek, F1
Chen, J; Guo, L; Tang, J; Xie, J; Xie, Y; Xu, B; Yan, L1
Thiermann, H; von der Wellen, J; Wille, T; Worek, F1
Antonijevic, B; Antonijevic, E; Djukic-Cosic, D; Kosvancova, A; Kotur-Stevuljevic, J; Kuca, K; Musilek, K; Spasojevic-Kalimanovska, V1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL1
John, H; Kranawetvogl, T; Steinritz, D; Thiermann, H1
Bedford, CD; Goff, DA; Harris, RN; Howd, RA; Koolpe, GA; Miller, A; Musallam, HA; Nolen, HW; Petesch, M; Pick, RO1
Bedford, CD; Bottaro, JC; Howd, RA; Miura, M; Nolen, HW1
Bedford, CD; Harris, RN; Howd, RA; Kenley, RA; Miller, A; Nolen, HW1
Bielavský, J; Cabal, J; Kassa, J; Kuca, K1
Dohnal, V; Dolezal, M; Jun, D; Kuca, K; Musilek, K1
Dohnal, V; Dolezal, M; Holas, O; Jun, D; Kuca, K; Musilek, K1
Dohnal, V; Dolezal, M; Holas, O; Jun, D; Kuca, K; Musilek, K; Opletalova, V1
Dohnal, V; Dolezal, M; Gunn-Moore, F; Holas, O; Jun, D; Kuca, K; Musilek, K; Opletalova, V1
Cabal, J; Gunn-Moore, F; Jun, D; Kassa, J; Kuca, K; Musilek, K1
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A1
Dohnal, V; Jun, D; Kuca, K; Kucera, J; Musilek, K; Opletalova, V1
Jeong, HC; Jung, YS; Kang, NS; Park, NJ; Yum, EK1
Dohnal, V; Dolezal, M; Gunn-Moore, F; Holas, O; Horova, A; Komloova, M; Kuca, K; Musilek, K; Pohanka, M1
Cashman, JR; Kalisiak, J; Ralph, EC; Zhang, J1
Arboléas, M; Baati, R; Gillon, E; Jean, L; Kliachyna, M; Loiodice, M; Mercey, G; Nachon, F; Renard, PY; Renou, J; Verdelet, T1
Amitai, G; Fokin, VV; Radić, Z; Sharpless, KB; Sit, RK; Taylor, P1
Acharya, J; Karade, HN; Kaushik, MP; Valiveti, AK1
Baati, R; Calas, AG; Coisne, C; Courageux, C; Da Silva, O; Dehouck, MP; Dias, J; Gastellier, AJ; Gosselet, F; Hanak, AS; Jean, L; Landry, C; Nachon, F; Probst, N; Renard, PY; Trancart, M; Warnault, P1
Andrys, R; Fingler, S; Hofmanova, T; Hrvat, NM; Katalinić, M; Kovarik, Z; Malinak, D; Maraković, N; Musilek, K; Prchal, L; Psotka, M; Svobodova, J; Zandona, A; Zorbaz, T; Žunec, S1

Reviews

1 review(s) available for obidoxime chloride and asoxime chloride

ArticleYear
Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.
    Chemico-biological interactions, 1999, May-14, Volume: 119-120

    Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Edrophonium; Kinetics; Mice; Obidoxime Chloride; Oximes; Phosphorylation; Pralidoxime Compounds; Pyridinium Compounds

1999

Other Studies

107 other study(ies) available for obidoxime chloride and asoxime chloride

ArticleYear
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.
    Archives of toxicology, 1992, Volume: 66, Issue:2

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds

1992
Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.
    Archives of toxicology, 1991, Volume: 65, Issue:7

    Topics: Animals; Antidotes; Blood-Brain Barrier; Cholinesterase Reactivators; Diaphragm; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Respiratory Insufficiency; Synaptic Transmission

1991
Hormone- and dose schedule-dependent protection by HI-6 against soman and tabun poisoning.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 12, Issue:3

    Topics: Animals; Body Weight; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Male; Obidoxime Chloride; Orchiectomy; Organophosphates; Organophosphorus Compounds; Ovariectomy; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Species Specificity; Testosterone; Time Factors

1989
Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats.
    Toxicology and applied pharmacology, 1987, Jun-30, Volume: 89, Issue:2

    Topics: Acetylcholinesterase; Animals; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin

1987
Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.
    Archives of toxicology, 1987, Volume: 61, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Soman

1987
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
    Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9

    Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism

1986
Bisquaternary pyridinium oximes as allosteric inhibitors of rat brain muscarinic receptors.
    Molecular pharmacology, 1985, Volume: 27, Issue:4

    Topics: Animals; Benzilates; Brain; Dose-Response Relationship, Drug; Kinetics; Mathematics; Obidoxime Chloride; Oximes; Piperidines; Pyridinium Compounds; Rats; Receptors, Muscarinic

1985
Reversible and irreversible inhibition of rat brain muscarinic receptors is related to different substitutions on bisquaternary pyridinium oximes.
    Archives of toxicology, 1985, Volume: 58, Issue:1

    Topics: Animals; Benzilates; Binding, Competitive; Brain Stem; Cell-Free System; Obidoxime Chloride; Oximes; Parasympatholytics; Piperidines; Pyridinium Compounds; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Trimedoxime

1985
Delayed neuropathy by the organophosphorus nerve agents soman and tabun.
    Archives of toxicology, 1984, Volume: 55, Issue:1

    Topics: Animals; Chickens; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Lethal Dose 50; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nervous System Diseases; Pyridinium Compounds; Soman

1984
[Trial of cholinesterase reactivators as proserine antagonists].
    Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:10

    Topics: Animals; Antidotes; Atropine; Butanones; Cholinesterase Reactivators; Diphenylacetic Acids; Drug Synergism; Male; Mice; Neostigmine; Obidoxime Chloride; Oximes; Parasympatholytics; Pralidoxime Compounds; Pyridinium Compounds; Trimedoxime

1983
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning.
    Human & experimental toxicology, 1995, Volume: 14, Issue:8

    Topics: Animals; Atropine; Blood Pressure; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Pyridostigmine Bromide; Respiration

1995
Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats.
    Toxicology, 1995, Aug-25, Volume: 101, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Reactivators; Cortisone; Female; Liver; Obidoxime Chloride; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tyrosine Transaminase

1995
In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human.
    Archives of toxicology, 1994, Volume: 68, Issue:10

    Topics: Acetylcholinesterase; Analysis of Variance; Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Humans; In Vitro Techniques; Macaca fascicularis; Male; Muscle, Skeletal; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Soman; Species Specificity; Tissue Preservation

1994
Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats.
    Archives of toxicology, 1994, Volume: 68, Issue:4

    Topics: Animals; Binding, Competitive; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Oximes; Pyridines; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Sarin; Synaptic Transmission

1994
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function.
    Archives of toxicology, 1994, Volume: 68, Issue:4

    Topics: Animals; Atropine; Blood Circulation; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiration

1994
Pharmacological nature of soman-induced hypothermia in mice.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3

    Topics: Acetylcholinesterase; Animals; Atropine; Body Temperature; Cholinesterase Inhibitors; Cholinesterase Reactivators; Hypothalamus; Hypothermia; Male; Mecamylamine; Mice; Nicotine; Obidoxime Chloride; Oximes; Oxotremorine; Physostigmine; Pyridinium Compounds; Soman

1993
Effect of pyridostigmine pretreatment, HI-6 and Toxogonin treatment on rat tracheal smooth muscle response to cholinergic stimulation after organophosphorus inhalation exposure.
    Archives of toxicology, 1993, Volume: 67, Issue:3

    Topics: Administration, Inhalation; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Electric Stimulation; Male; Muscle Contraction; Muscle, Smooth; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Soman; Trachea

1993
Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methylphosphonofluoridate (GF) in rats.
    Human & experimental toxicology, 1995, Volume: 14, Issue:11

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Corticosterone; Diaphragm; Drug Interactions; Liver; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tyrosine Transaminase

1995
[Comparison of the therapeutic effectiveness of selected cholinesterase reactivators with atropine in acute fosdrine poisoning in mice].
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1996, Volume: 45, Issue:1

    Topics: Acute Disease; Animals; Atropine; Cholinesterase Reactivators; Insecticides; Male; Mevinphos; Mice; Obidoxime Chloride; Oximes; Poisoning; Pyridinium Compounds

1996
The influence of pharmacological pretreatment on efficacy of HI-6 oxime in combination with benactyzine in soman poisoning in rats.
    Human & experimental toxicology, 1996, Volume: 15, Issue:5

    Topics: Animals; Antidotes; Benactyzine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Corticosterone; Diaphragm; Drug Therapy, Combination; Liver; Male; Muscarinic Antagonists; Obidoxime Chloride; Oximes; Poisoning; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Soman; Trihexyphenidyl; Tyrosine Transaminase

1996
In vitro effects of toxogonin, HI-6 and HLö-7 on the release of [3H]acetylcholine from peripheral cholinergic nerves in rat airway smooth muscle.
    European journal of pharmacology, 1996, Apr-22, Volume: 301, Issue:1-3

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Bronchi; Butyrylcholinesterase; Calcium Channel Blockers; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Male; Muscle, Smooth; Obidoxime Chloride; Oximes; Parasympathetic Nervous System; Peripheral Nerves; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman

1996
A comparison of two oximes (HI-6 and obidoxime) for 2-dimethylaminoethyl-(dimethylamido)-phosphonofluoridate poisoning.
    Pharmacology & toxicology, 1995, Volume: 77, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterases; Corticosterone; Diaphragm; Liver; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tyrosine Transaminase

1995
Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice.
    Acta medica (Hradec Kralove), 1996, Volume: 39, Issue:1

    Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Gas Poisoning; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman

1996
The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice.
    Pharmacology & toxicology, 1997, Volume: 81, Issue:3

    Topics: Animals; Atropine; Cholinesterase Reactivators; Insecticides; Lethal Dose 50; Male; Mevinphos; Mice; Muscarinic Antagonists; Obidoxime Chloride; Oximes; Pyridinium Compounds; Structure-Activity Relationship

1997
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.
    Archives of toxicology, 1998, Volume: 72, Issue:4

    Topics: Acetylcholinesterase; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Soman

1998
[Comparison of the reactivation effects of the HI-6 oxime and obidoximeon cyclosin-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats].
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1998, Volume: 47, Issue:1

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Reactivators; Diaphragm; Enzyme Activation; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar

1998
A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats.
    Human & experimental toxicology, 1998, Volume: 17, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Liver; Male; Obidoxime Chloride; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tyrosine Transaminase

1998
Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics.
    Archives of toxicology, 1999, Volume: 73, Issue:1

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Humans; Insecticides; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Paraoxon; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Time Factors

1999
[Comparison of the effects of BI-6, a new asymmetric bipyridine oxime, with HI-6 oxime and obidoxime in combination with atropine on soman and fosdrine toxicity in mice].
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1999, Volume: 48, Issue:1

    Topics: Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Insecticides; Male; Mevinphos; Mice; Mice, Inbred Strains; Obidoxime Chloride; Oximes; Pyridinium Compounds; Soman

1999
Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium.
    Biochemistry, 1999, Aug-03, Volume: 38, Issue:31

    Topics: Acetylcholinesterase; Animals; Cattle; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Edrophonium; Enzyme Activation; Fetal Blood; Hydrolysis; Kinetics; Mice; Nuclear Magnetic Resonance, Biomolecular; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Phosphorus Isotopes; Pyridinium Compounds; Quinolinium Compounds; Recombinant Proteins

1999
[Comparison of the reactivating effect of BI-6, a new asymmetrical bispyridinium oxime, with oxime HI-6 and obidoxime on soman-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats].
    Casopis lekaru ceskych, 1999, Aug-30, Volume: 138, Issue:17

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Male; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman

1999
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase.
    Archives of toxicology, 2000, Volume: 74, Issue:1

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Aging; Erythrocytes; Humans; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Sarin

2000
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
    Archives of toxicology, 2002, Volume: 76, Issue:9

    Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity

2002
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.
    Pharmacology & toxicology, 2003, Volume: 92, Issue:6

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar

2003
Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines.
    Archives of toxicology, 2004, Volume: 78, Issue:4

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Phosphorylcholine; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Spectrophotometry; Time Factors

2004
In vitro reactivation of acetylcholinesterase using the oxime K027.
    Veterinary and human toxicology, 2004, Volume: 46, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2004
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
    Die Pharmazie, 2004, Volume: 59, Issue:10

    Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2004
Pre-junctional effects of oximes on [3H]-acetylcholine release in rat hippocampal slices during soman intoxication.
    European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Oximes; Potassium; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tritium

2005
In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes.
    Journal of enzyme inhibition and medicinal chemistry, 2005, Volume: 20, Issue:3

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Species Specificity; Structure-Activity Relationship; Swine

2005
A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
    Acta medica (Hradec Kralove), 2005, Volume: 48, Issue:2

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; In Vitro Techniques; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar

2005
Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2005, Volume: 149, Issue:2

    Topics: Animals; Cholinesterase Reactivators; Female; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats

2005
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
    Journal of toxicology and environmental health. Part A, 2006, Volume: 69, Issue:15

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2006
Pyridinium, imidazolium and quinuclidinium compounds: toxicity and antidotal effects against the nerve agents Tabun and Soman.
    Arhiv za higijenu rada i toksikologiju, 2006, Volume: 57, Issue:2

    Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Trimedoxime

2006
Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates.
    Biochemical pharmacology, 2006, Aug-28, Volume: 72, Issue:5

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Nitrogen; Obidoxime Chloride; Organophosphates; Oximes; Protein Conformation; Pyridinium Compounds

2006
A comparison of the potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats.
    Toxicology, 2007, Jan-05, Volume: 229, Issue:1-2

    Topics: Animals; Antidotes; Atropine; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinergic Antagonists; Dose-Response Relationship, Drug; Injections, Intramuscular; Lacrimal Apparatus; Male; Miosis; Molecular Structure; Muscle Tonus; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tears; Time Factors; Toxicity Tests; Treatment Outcome

2007
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
    Archives of toxicology, 2007, Volume: 81, Issue:6

    Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet

2007
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:1

    Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime

2007
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases.
    Neurotoxicity research, 2007, Volume: 11, Issue:2

    Topics: Acetylcholinesterase; Butanes; Caudate Nucleus; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; In Vitro Techniques; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds

2007
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) to counteract soman-induced neurotoxicity in rats.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:2

    Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Structure-Activity Relationship

2007
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats.
    Journal of enzyme inhibition and medicinal chemistry, 2007, Volume: 22, Issue:3

    Topics: Animals; Antidotes; Brain; Butanes; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Male; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Structure-Activity Relationship

2007
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
    Toxicology, 2008, Jan-20, Volume: 243, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime

2008
Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2006, Volume: 2, Issue:4

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Research Design; Sarin; Swine

2006
Potency of novel oximes to reactivate sarin inhibited human cholinesterases.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:1

    Topics: Acetylcholinesterase; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; In Vitro Techniques; Molecular Structure; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:1

    Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime

2008
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Diaphragm; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2008
An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:1

    Topics: Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Treatment Outcome

2009
The influence of acetylcholinesterase reactivators on selected hepatic functions in rats.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 103, Issue:2

    Topics: Animals; ATP-Binding Cassette Transporters; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Fatty Liver; Lethal Dose 50; Lipid Metabolism; Liver; Male; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Wistar

2008
In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048.
    Journal of enzyme inhibition and medicinal chemistry, 2009, Volume: 24, Issue:3

    Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Trichlorfon

2009
Evaluation of the neuroprotective efficacy of newly developed oximes (K206, K269) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 104, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Muscarinic Antagonists; Neuroprotective Agents; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar

2009
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
    Toxicology, 2009, May-17, Volume: 259, Issue:3

    Topics: Acetylcholinesterase; Biomarkers; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds

2009
Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.
    Toxicology letters, 2009, Jun-01, Volume: 187, Issue:2

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin

2009
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice.
    Journal of applied toxicology : JAT, 2010, Volume: 30, Issue:2

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar

2010
Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6.
    Toxicology mechanisms and methods, 2009, Volume: 19, Issue:4

    Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Isoflurophate; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2009
Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration.
    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2010, Volume: 26, Issue:1

    Topics: Animals; Blood Proteins; Calibration; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Indicators and Reagents; Injections, Intramuscular; Male; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Reproducibility of Results; Spectrophotometry, Ultraviolet; Trichloroacetic Acid

2010
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
    Chemico-biological interactions, 2010, Sep-06, Volume: 187, Issue:1-3

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; Kinetics; Obidoxime Chloride; Organophosphates; Oximes; Protein Binding; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2010
A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice.
    Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:4

    Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Trimedoxime

2010
Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro.
    Toxicology, 2010, Jun-04, Volume: 272, Issue:1-3

    Topics: Acetylcholinesterase; Animals; Diaphragm; Humans; Male; Mice; Mice, Inbred Strains; Obidoxime Chloride; Oximes; Paraoxon; Physical Phenomena; Pralidoxime Compounds; Pyridinium Compounds

2010
A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice.
    Drug and chemical toxicology, 2010, Volume: 33, Issue:3

    Topics: Acetylcholinesterase; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar

2010
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.
    Toxicology letters, 2011, Jan-15, Volume: 200, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Drug Interactions; Enzyme Reactivators; Guinea Pigs; Humans; Kinetics; Macaca mulatta; Obidoxime Chloride; Oximes; Paraoxon; Pralidoxime Compounds; Pyridinium Compounds; Rabbits; Rats; Rats, Wistar; Species Specificity; Swine

2011
A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques.
    Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:6

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Frontal Lobe; GPI-Linked Proteins; Lethal Dose 50; Obidoxime Chloride; Organ Specificity; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Reticular Formation

2010
A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
    Toxicology mechanisms and methods, 2011, Volume: 21, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2011
In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity.
    Toxicology letters, 2011, Mar-05, Volume: 201, Issue:2

    Topics: Animals; Brain; Cholinesterase Reactivators; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Swine; Trimedoxime

2011
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
    Chemical communications (Cambridge, England), 2011, May-14, Volume: 47, Issue:18

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Erythrocytes; Humans; Molecular Structure; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridines; Pyridinium Compounds; Soman

2011
Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors.
    Physiological research, 2011, Volume: 60, Issue:4

    Topics: Animals; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Male; Nicotinic Antagonists; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2011
Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method.
    International journal of molecular sciences, 2011, Volume: 12, Issue:4

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dithionitrobenzoic Acid; Enzyme Assays; Indoles; Kinetics; Obidoxime Chloride; Oximes; Paraoxon; Pralidoxime Compounds; Pyridinium Compounds; Substrate Specificity

2011
[Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos].
    Vojnosanitetski pregled, 2011, Volume: 68, Issue:12

    Topics: Animals; Antidotes; Cholinesterase Reactivators; Dichlorvos; Drug Therapy, Combination; Male; Memantine; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman

2011
A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:5

    Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Czech Republic; Drug Therapy, Combination; Lethal Dose 50; Male; Muscarinic Antagonists; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Psychomotor Performance; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2012
A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; GPI-Linked Proteins; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Quantitative Structure-Activity Relationship; Recombinant Proteins; Sarin

2013
Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Electrochemistry; GPI-Linked Proteins; Humans; Molecular Structure; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Recombinant Proteins

2013
Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications.
    Toxicology letters, 2014, Nov-18, Volume: 231, Issue:1

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; GPI-Linked Proteins; Humans; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Time Factors

2014
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.
    Toxicology mechanisms and methods, 2015, Volume: 25, Issue:3

    Topics: Acetylcholinesterase; Animals; Animals, Outbred Strains; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats, Wistar; Sarin

2015
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.
    Toxicology, 2016, 03-28, Volume: 350-352

    Topics: Acetylcholinesterase; Cholinesterase Reactivators; Drug Therapy, Combination; Humans; Inhalation Exposure; Injections, Intramuscular; Models, Biological; Nerve Agents; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Toxicokinetics

2016
A liquid chromatography tandem mass spectrometric method on in vitro nerve agents poisoning characterization and reactivator efficacy evaluation by determination of specific peptide adducts in acetylcholinesterase.
    Journal of chromatography. A, 2016, Jun-10, Volume: 1450

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, Liquid; Colorimetry; Enzyme Activation; Humans; In Vitro Techniques; Nerve Agents; Obidoxime Chloride; Oximes; Peptide Fragments; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Tandem Mass Spectrometry

2016
Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6.
    Archives of toxicology, 2017, Volume: 91, Issue:3

    Topics: Acetylcholinesterase; Binding Sites; Blood Specimen Collection; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Erythrocytes; Freezing; Humans; Inactivation, Metabolic; Obidoxime Chloride; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds

2017
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain.
    Archives of toxicology, 2018, Volume: 92, Issue:2

    Topics: Animals; Aryldialkylphosphatase; Biomarkers; Brain; Cholinesterase Inhibitors; Dichlorvos; Male; Malondialdehyde; Obidoxime Chloride; Organophosphate Poisoning; Oxidative Stress; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Superoxide Dismutase; Trimedoxime

2018
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
    Toxicology, 2018, 09-01, Volume: 408

    Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors

2018
A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.
    Drug testing and analysis, 2020, Volume: 12, Issue:7

    Topics: Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Humans; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Reproducibility of Results

2020
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:2

    Topics: Animals; Cattle; Cholinesterase Reactivators; Eels; Humans; Imidazoles; Imines; Kinetics; Mice; Organophosphorus Compounds; Receptors, Cholinergic; Soman; Structure-Activity Relationship

1989
Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:9

    Topics: Acetylcholinesterase; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Hydrogen-Ion Concentration; Kinetics; Organophosphorus Compounds; Organothiophosphates; Organothiophosphorus Compounds; Soman; Structure-Activity Relationship

1986
Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:11

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Eels; Hydroxylamines; Imidazoles; Mathematics; Organophosphorus Compounds; Soman; Structure-Activity Relationship

1984
Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.
    Bioorganic & medicinal chemistry letters, 2003, Oct-20, Volume: 13, Issue:20

    Topics: Cholinesterase Inhibitors; Enzyme Reactivators; Kinetics; Organophosphates

2003
Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.
    Bioorganic & medicinal chemistry letters, 2006, Volume: 16, Issue:3

    Topics: Acetylcholinesterase; Animals; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Hydrocarbons, Brominated; Nitrogen; Oximes; Pyridinium Compounds; Rats

2006
Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
    Bioorganic & medicinal chemistry letters, 2006, Nov-01, Volume: 16, Issue:21

    Topics: Cholinesterase Inhibitors; Nitriles; Organophosphates; Paraoxon; Pyridinium Compounds

2006
Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
    Bioorganic & medicinal chemistry letters, 2007, Jun-01, Volume: 17, Issue:11

    Topics: Acetylcholinesterase; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Organophosphates; Oximes; Paraoxon; Pyridinium Compounds

2007
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.
    Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Design; Organophosphates; Oximes; Paraoxon; Rats; Structure-Activity Relationship

2007
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).
    Journal of medicinal chemistry, 2007, Nov-01, Volume: 50, Issue:22

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Design; Kinetics; Organophosphates; Oximes; Pyridinium Compounds; Structure-Activity Relationship

2007
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine

2008
Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase.
    Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Activators; Models, Biological; Molecular Structure; Organophosphates; Paraoxon; Pyridinium Compounds; Rats; Stereoisomerism; Structure-Activity Relationship

2008
Reactivation potency of fluorinated pyridinium oximes for acetylcholinesterases inhibited by paraoxon organophosphorus agent.
    Bioorganic & medicinal chemistry letters, 2009, Feb-15, Volume: 19, Issue:4

    Topics: Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Houseflies; Molecular Structure; Organophosphorus Compounds; Oximes; Paraoxon

2009
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.
    Bioorganic & medicinal chemistry, 2011, Jan-15, Volume: 19, Issue:2

    Topics: Acetylcholinesterase; Binding Sites; Catalytic Domain; Cholinesterase Reactivators; Computer Simulation; Humans; Hydrogen Bonding; Organophosphorus Compounds; Oximes; Structure-Activity Relationship

2011
Amidine-oximes: reactivators for organophosphate exposure.
    Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9

    Topics: Acetylcholinesterase; Amidines; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterases; Enzyme Reactivators; Female; Humans; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Permeability; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship

2011
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.
    Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Enzyme Reactivators; Humans; Isoquinolines; Magnetic Resonance Spectroscopy; Oximes; Phosphorylation

2012
Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.
    Journal of medicinal chemistry, 2014, Feb-27, Volume: 57, Issue:4

    Topics: Butyrylcholinesterase; Catalysis; Imidazoles; Models, Molecular; Molecular Structure; Organophosphorus Compounds; Oximes

2014
Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).
    Bioorganic & medicinal chemistry, 2014, May-01, Volume: 22, Issue:9

    Topics: Acetamides; Acetylcholinesterase; Enzyme Assays; Humans; Kinetics; Organothiophosphorus Compounds; Oximes; Protein Binding; Pyridines; Sarin

2014
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
    Journal of medicinal chemistry, 2022, 03-24, Volume: 65, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Sugars

2022
Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.
    European journal of medicinal chemistry, 2022, Aug-05, Volume: 238

    Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Halogens; Mice; Nerve Agents; Organophosphorus Compounds; Oximes; Sarin

2022