Page last updated: 2024-09-04

o-desmethylindomethacin and indomethacin

o-desmethylindomethacin has been researched along with indomethacin in 23 studies

Compound Research Comparison

Studies
(o-desmethylindomethacin)
Trials
(o-desmethylindomethacin)
Recent Studies (post-2010)
(o-desmethylindomethacin)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
270429,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyo-desmethylindomethacin (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19905 (21.74)18.7374
1990's10 (43.48)18.2507
2000's7 (30.43)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arisawa, M; Hamada, R; Itai, A; Iwata, Y; Kita, Y; Miyamoto, S; Mizutani, MY; Tomioka, N1
Augustyniak, ME; Cochran, ED; Ellis, JL; Fang, X; Garvey, DS; Janero, DR; Letts, LG; Martino, AM; Melim, TL; Murty, MG; Richardson, SK; Schroeder, JD; Selig, WM; Trocha, AM; Wexler, RS; Wey, SJ; Young, DV; Zemtseva, IS; Zifcak, BM1
Gomita, Y; Oishi, R; Yoshida, T1
Bockaert, J; Leviel, V; Varrault, A1
Platt, JE; Slucky, AV; Stone, EA; Trullas, R1
Iwasaki, K; Noda, K; Noguchi, H; Shiraga, T; Tada, K1
Cuisinaud, G; Guissou, P; Sassard, J1
Benet, LZ; Smith, PC1
Castranova, V; Jones, G; Ma, J; Peden, D; Van Dyke, C; Van Dyke, K1
van den Biggelaar-Martea, M; van Ewijk-Beneken Kolmer, EW; Verwey-van Wissen, CP; Vree, TB1
van den Biggelaar-Martea, M; Verwey-van Wissen, CP; Vree, TB1
Gallo, RV; Zhen, S1
Gorfien, JL; Ignatowski, TA; Noble, BK; Spengler, RN; Wright, JR1
Bert, L; Denoroy, L; Lambás-Señas, L; Renaud, B; Robert, F1
Novotney, S; Yamamoto, BK1
Dunn-Meynell, AA; Hassanain, M; Levin, BE1
Cataudella, T; Dimauro, R; Leanza, G; Monaco, S; Stanzani, S1
Kowalczyk, M; Lapo, I; Massi, M; Panocka, I; Sadowski, B; Swiderski, T1
Abdali, SA; Kalsner, S1
Devoto, P; Flore, G; Gessa, GL; Longu, G; Pira, L1
Felts, AS; Mackenzie, BS; Marnett, LJ; Prusakiewicz, JJ1
Huang, HH; Lin, LH; Xu, HY; Zhang, P; Zhong, DF1
Leeder, JS; Lewis, T; Scott, A; Van Haandel, L1

Other Studies

23 other study(ies) available for o-desmethylindomethacin and indomethacin

ArticleYear
Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis.
    Journal of medicinal chemistry, 2001, May-24, Volume: 44, Issue:11

    Topics: Aldehyde Reductase; Binding Sites; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Databases, Factual; Drug Design; Enzyme Inhibitors; Indoles; Ligands; Models, Molecular; Stereoisomerism

2001
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
    Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25

    Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Synergism; Female; Gastric Mucosa; Humans; Hydroxamic Acids; Indomethacin; Male; Nitric Oxide Donors; Pyrazoles; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfonamides

2007
Effect of cigarette smoke on pharmacokinetics of oral, intrarectal, or intravenous indomethacin in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 344, Issue:4

    Topics: Administration, Oral; Administration, Rectal; Animals; Indomethacin; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Smoking; Spectrophotometry, Ultraviolet

1991
5-HT1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Animals; Antidepressive Agents; Cells, Cultured; Clorgyline; Fluoxetine; Hippocampus; Indomethacin; Mice; Pyrimidines; Receptors, Serotonin; Serotonin

1991
Reduction of the cyclic adenosine 3',5'-monophosphate response to catecholamines in rat brain slices after repeated restraint stress.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Brain; Cerebral Cortex; Cyclic AMP; Dihydroalprenolol; Humans; Hypothalamus; Indomethacin; Isoproterenol; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Restraint, Physical; Stress, Psychological

1985
N-sulphoconjugation of alicyclic, alkyl- and aryl-amines in vivo and in vitro.
    Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:7

    Topics: Adenine Nucleotides; Alkanesulfonates; Amines; Animals; Arylsulfonates; Chromatography, Thin Layer; Female; Indomethacin; Phosphoadenosine Phosphosulfate; Piperazines; Rats; Rats, Inbred Strains; Sulfur Radioisotopes

1986
Gas chromatographic determination of indomethacin and its O-desmethylated metabolite in human plasma and urine.
    Journal of chromatography, 1983, Oct-14, Volume: 277

    Topics: Chromatography, Gas; Humans; Indomethacin

1983
High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine.
    Journal of chromatography, 1984, Mar-09, Volume: 306

    Topics: Chromatography, High Pressure Liquid; Humans; Indoleacetic Acids; Indomethacin; Spectrophotometry, Ultraviolet

1984
Inhibition by nonsteroidal antiinflammatory drugs of luminol-dependent human-granulocyte chemiluminescence and [3H]FMLP binding. Effect of sulindac sulfide, indomethacin metabolite, and optical enantiomers (+) and (-) MK830.
    Inflammation, 1982, Volume: 6, Issue:1

    Topics: Anti-Inflammatory Agents; Granulocytes; Humans; In Vitro Techniques; Indenes; Indomethacin; Luminescent Measurements; Luminol; Methionine; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Pyridazines; Sulindac; Tritium

1982
Probenecid inhibits the glucuronidation of indomethacin and O-desmethylindomethacin in humans. A pilot experiment.
    Pharmacy world & science : PWS, 1994, Feb-18, Volume: 16, Issue:1

    Topics: Chromatography, High Pressure Liquid; Glucuronates; Humans; Indomethacin; Kidney; Male; Middle Aged; Pilot Projects; Probenecid

1994
Determination of indomethacin, its metabolites and their glucuronides in human plasma and urine by means of direct gradient high-performance liquid chromatographic analysis. Preliminary pharmacokinetics and effect of probenecid.
    Journal of chromatography, 1993, Jul-02, Volume: 616, Issue:2

    Topics: Chromatography, High Pressure Liquid; Glucuronates; Humans; Hydrogen-Ion Concentration; Indoleacetic Acids; Indomethacin; Isomerism; Male; Middle Aged; Pilot Projects; Probenecid

1993
The role of norepinephrine in mediating luteinizing hormone release in response to blockade of kappa-opioid receptors in the medial preoptic area.
    Brain research, 1995, Nov-06, Volume: 698, Issue:1-2

    Topics: Animals; Basal Metabolism; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Female; Indomethacin; Luteinizing Hormone; Naltrexone; Norepinephrine; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Secretory Rate

1995
TNFalpha: a neuromodulator in the central nervous system.
    Advances in experimental medicine and biology, 1996, Volume: 402

    Topics: Animals; Brain; Immunohistochemistry; Indomethacin; Male; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

1996
In vivo monitoring of extracellular noradrenaline and glutamate from rat brain cortex with 2-min microdialysis sampling using capillary electrophoresis with laser-induced fluorescence detection.
    Journal of neuroscience methods, 1996, Dec-28, Volume: 70, Issue:2

    Topics: Animals; Aspartic Acid; Clonidine; Electrophoresis, Capillary; Evaluation Studies as Topic; Extracellular Space; Fluorescent Dyes; Glutamic Acid; Indomethacin; Lasers; Male; Microdialysis; Microelectrodes; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sympatholytics

1996
Regulation of extracellular dopamine by the norepinephrine transporter.
    Journal of neurochemistry, 1998, Volume: 71, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Carrier Proteins; Caudate Nucleus; Dopamine; Dopamine Antagonists; Extracellular Space; Haloperidol; Idazoxan; Indomethacin; Male; Microdialysis; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Symporters

1998
Norepinephrine and traumatic brain injury: a possible role in post-traumatic edema.
    Brain research, 1998, Aug-03, Volume: 800, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Brain Concussion; Brain Edema; Brain Stem; Cerebellum; Hypothalamus; Indomethacin; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Somatosensory Cortex

1998
Release properties and functional integration of noradrenergic-rich tissue grafted to the denervated spinal cord of the adult rat.
    The European journal of neuroscience, 1999, Volume: 11, Issue:5

    Topics: Age Factors; Animals; Behavior, Animal; Brain Tissue Transplantation; Dopamine beta-Hydroxylase; Female; Fetal Tissue Transplantation; Graft Survival; Indomethacin; Locus Coeruleus; Microdialysis; Nerve Fibers; Norepinephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Superior Cervical Ganglion; Synaptic Transmission

1999
Antidepressant-type effect of the NK3 tachykinin receptor agonist aminosenktide in mouse lines differing in endogenous opioid system activity.
    Peptides, 2001, Volume: 22, Issue:7

    Topics: Analgesia; Animals; Antidepressive Agents; Behavior, Animal; Cell Line; Dose-Response Relationship, Drug; Female; Indomethacin; Male; Mice; Naltrexone; Narcotics; Peptide Fragments; Receptors, Tachykinin; Substance P; Swimming

2001
Decrements in per pulse release of norepinephrine, antagonist potentiation of release and presynaptic receptor theory.
    Brain research bulletin, 2003, Jul-15, Volume: 61, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Drug Interactions; Electric Stimulation; Feedback; Hippocampus; In Vitro Techniques; Indomethacin; Norepinephrine; Rabbits; Receptors, Presynaptic; Time Factors; Tritium; Yohimbine

2003
Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex.
    Journal of neurochemistry, 2004, Volume: 88, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-2 Receptor Antagonists; Animals; Cerebral Cortex; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Extracellular Space; Haloperidol; Indomethacin; Male; Microdialysis; Neurons; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors

2004
Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin.
    Biochemistry, 2004, Dec-14, Volume: 43, Issue:49

    Topics: Amino Acid Substitution; Animals; Binding Sites; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Isoenzymes; Kinetics; Male; Mice; Prostaglandin-Endoperoxide Synthases; Sheep; Spectrometry, Fluorescence; Substrate Specificity; Time Factors

2004
Biotransformation of indomethacin by the fungus Cunninghamella blakesleeana.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Chromatography, Liquid; Cunninghamella; Indoleacetic Acids; Indomethacin; Magnetic Resonance Spectroscopy; Mass Spectrometry

2006
Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
    Pediatric research, 2018, Volume: 84, Issue:3

    Topics: Drug Administration Schedule; Ductus Arteriosus, Patent; Female; Glucuronides; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intensive Care Units, Neonatal; Male; Urine Specimen Collection

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