o-desmethylindomethacin and indomethacin
o-desmethylindomethacin has been researched along with indomethacin in 23 studies
Compound Research Comparison
| Studies (o-desmethylindomethacin) | Trials (o-desmethylindomethacin) | Recent Studies (post-2010) (o-desmethylindomethacin) | Studies (indomethacin) | Trials (indomethacin) | Recent Studies (post-2010) (indomethacin) |
|---|---|---|---|---|---|
| 27 | 0 | 4 | 29,527 | 1,838 | 3,396 |
Protein Interaction Comparison
Research
Studies (23)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Arisawa, M; Hamada, R; Itai, A; Iwata, Y; Kita, Y; Miyamoto, S; Mizutani, MY; Tomioka, N | 1 |
| Augustyniak, ME; Cochran, ED; Ellis, JL; Fang, X; Garvey, DS; Janero, DR; Letts, LG; Martino, AM; Melim, TL; Murty, MG; Richardson, SK; Schroeder, JD; Selig, WM; Trocha, AM; Wexler, RS; Wey, SJ; Young, DV; Zemtseva, IS; Zifcak, BM | 1 |
| Gomita, Y; Oishi, R; Yoshida, T | 1 |
| Bockaert, J; Leviel, V; Varrault, A | 1 |
| Platt, JE; Slucky, AV; Stone, EA; Trullas, R | 1 |
| Iwasaki, K; Noda, K; Noguchi, H; Shiraga, T; Tada, K | 1 |
| Cuisinaud, G; Guissou, P; Sassard, J | 1 |
| Benet, LZ; Smith, PC | 1 |
| Castranova, V; Jones, G; Ma, J; Peden, D; Van Dyke, C; Van Dyke, K | 1 |
| van den Biggelaar-Martea, M; van Ewijk-Beneken Kolmer, EW; Verwey-van Wissen, CP; Vree, TB | 1 |
| van den Biggelaar-Martea, M; Verwey-van Wissen, CP; Vree, TB | 1 |
| Gallo, RV; Zhen, S | 1 |
| Gorfien, JL; Ignatowski, TA; Noble, BK; Spengler, RN; Wright, JR | 1 |
| Bert, L; Denoroy, L; Lambás-Señas, L; Renaud, B; Robert, F | 1 |
| Novotney, S; Yamamoto, BK | 1 |
| Dunn-Meynell, AA; Hassanain, M; Levin, BE | 1 |
| Cataudella, T; Dimauro, R; Leanza, G; Monaco, S; Stanzani, S | 1 |
| Kowalczyk, M; Lapo, I; Massi, M; Panocka, I; Sadowski, B; Swiderski, T | 1 |
| Abdali, SA; Kalsner, S | 1 |
| Devoto, P; Flore, G; Gessa, GL; Longu, G; Pira, L | 1 |
| Felts, AS; Mackenzie, BS; Marnett, LJ; Prusakiewicz, JJ | 1 |
| Huang, HH; Lin, LH; Xu, HY; Zhang, P; Zhong, DF | 1 |
| Leeder, JS; Lewis, T; Scott, A; Van Haandel, L | 1 |
Other Studies
23 other study(ies) available for o-desmethylindomethacin and indomethacin
| Article | Year |
|---|---|
Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis.
Topics: Aldehyde Reductase; Binding Sites; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Databases, Factual; Drug Design; Enzyme Inhibitors; Indoles; Ligands; Models, Molecular; Stereoisomerism | 2001 |
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Synergism; Female; Gastric Mucosa; Humans; Hydroxamic Acids; Indomethacin; Male; Nitric Oxide Donors; Pyrazoles; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfonamides | 2007 |
Effect of cigarette smoke on pharmacokinetics of oral, intrarectal, or intravenous indomethacin in rats.
Topics: Administration, Oral; Administration, Rectal; Animals; Indomethacin; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Smoking; Spectrophotometry, Ultraviolet | 1991 |
5-HT1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antidepressive Agents; Cells, Cultured; Clorgyline; Fluoxetine; Hippocampus; Indomethacin; Mice; Pyrimidines; Receptors, Serotonin; Serotonin | 1991 |
Reduction of the cyclic adenosine 3',5'-monophosphate response to catecholamines in rat brain slices after repeated restraint stress.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Cerebral Cortex; Cyclic AMP; Dihydroalprenolol; Humans; Hypothalamus; Indomethacin; Isoproterenol; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Restraint, Physical; Stress, Psychological | 1985 |
N-sulphoconjugation of alicyclic, alkyl- and aryl-amines in vivo and in vitro.
Topics: Adenine Nucleotides; Alkanesulfonates; Amines; Animals; Arylsulfonates; Chromatography, Thin Layer; Female; Indomethacin; Phosphoadenosine Phosphosulfate; Piperazines; Rats; Rats, Inbred Strains; Sulfur Radioisotopes | 1986 |
Gas chromatographic determination of indomethacin and its O-desmethylated metabolite in human plasma and urine.
Topics: Chromatography, Gas; Humans; Indomethacin | 1983 |
High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine.
Topics: Chromatography, High Pressure Liquid; Humans; Indoleacetic Acids; Indomethacin; Spectrophotometry, Ultraviolet | 1984 |
Inhibition by nonsteroidal antiinflammatory drugs of luminol-dependent human-granulocyte chemiluminescence and [3H]FMLP binding. Effect of sulindac sulfide, indomethacin metabolite, and optical enantiomers (+) and (-) MK830.
Topics: Anti-Inflammatory Agents; Granulocytes; Humans; In Vitro Techniques; Indenes; Indomethacin; Luminescent Measurements; Luminol; Methionine; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Pyridazines; Sulindac; Tritium | 1982 |
Probenecid inhibits the glucuronidation of indomethacin and O-desmethylindomethacin in humans. A pilot experiment.
Topics: Chromatography, High Pressure Liquid; Glucuronates; Humans; Indomethacin; Kidney; Male; Middle Aged; Pilot Projects; Probenecid | 1994 |
Determination of indomethacin, its metabolites and their glucuronides in human plasma and urine by means of direct gradient high-performance liquid chromatographic analysis. Preliminary pharmacokinetics and effect of probenecid.
Topics: Chromatography, High Pressure Liquid; Glucuronates; Humans; Hydrogen-Ion Concentration; Indoleacetic Acids; Indomethacin; Isomerism; Male; Middle Aged; Pilot Projects; Probenecid | 1993 |
The role of norepinephrine in mediating luteinizing hormone release in response to blockade of kappa-opioid receptors in the medial preoptic area.
Topics: Animals; Basal Metabolism; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Female; Indomethacin; Luteinizing Hormone; Naltrexone; Norepinephrine; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Secretory Rate | 1995 |
TNFalpha: a neuromodulator in the central nervous system.
Topics: Animals; Brain; Immunohistochemistry; Indomethacin; Male; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 1996 |
In vivo monitoring of extracellular noradrenaline and glutamate from rat brain cortex with 2-min microdialysis sampling using capillary electrophoresis with laser-induced fluorescence detection.
Topics: Animals; Aspartic Acid; Clonidine; Electrophoresis, Capillary; Evaluation Studies as Topic; Extracellular Space; Fluorescent Dyes; Glutamic Acid; Indomethacin; Lasers; Male; Microdialysis; Microelectrodes; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sympatholytics | 1996 |
Regulation of extracellular dopamine by the norepinephrine transporter.
Topics: Adrenergic alpha-Antagonists; Animals; Carrier Proteins; Caudate Nucleus; Dopamine; Dopamine Antagonists; Extracellular Space; Haloperidol; Idazoxan; Indomethacin; Male; Microdialysis; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Symporters | 1998 |
Norepinephrine and traumatic brain injury: a possible role in post-traumatic edema.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Brain Concussion; Brain Edema; Brain Stem; Cerebellum; Hypothalamus; Indomethacin; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Somatosensory Cortex | 1998 |
Release properties and functional integration of noradrenergic-rich tissue grafted to the denervated spinal cord of the adult rat.
Topics: Age Factors; Animals; Behavior, Animal; Brain Tissue Transplantation; Dopamine beta-Hydroxylase; Female; Fetal Tissue Transplantation; Graft Survival; Indomethacin; Locus Coeruleus; Microdialysis; Nerve Fibers; Norepinephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Superior Cervical Ganglion; Synaptic Transmission | 1999 |
Antidepressant-type effect of the NK3 tachykinin receptor agonist aminosenktide in mouse lines differing in endogenous opioid system activity.
Topics: Analgesia; Animals; Antidepressive Agents; Behavior, Animal; Cell Line; Dose-Response Relationship, Drug; Female; Indomethacin; Male; Mice; Naltrexone; Narcotics; Peptide Fragments; Receptors, Tachykinin; Substance P; Swimming | 2001 |
Decrements in per pulse release of norepinephrine, antagonist potentiation of release and presynaptic receptor theory.
Topics: Adrenergic alpha-Antagonists; Animals; Drug Interactions; Electric Stimulation; Feedback; Hippocampus; In Vitro Techniques; Indomethacin; Norepinephrine; Rabbits; Receptors, Presynaptic; Time Factors; Tritium; Yohimbine | 2003 |
Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-2 Receptor Antagonists; Animals; Cerebral Cortex; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Extracellular Space; Haloperidol; Indomethacin; Male; Microdialysis; Neurons; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors | 2004 |
Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Isoenzymes; Kinetics; Male; Mice; Prostaglandin-Endoperoxide Synthases; Sheep; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2004 |
Biotransformation of indomethacin by the fungus Cunninghamella blakesleeana.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Chromatography, Liquid; Cunninghamella; Indoleacetic Acids; Indomethacin; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2006 |
Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Topics: Drug Administration Schedule; Ductus Arteriosus, Patent; Female; Glucuronides; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intensive Care Units, Neonatal; Male; Urine Specimen Collection | 2018 |