Compounds > o-desmethylindomethacin
Page last updated: 2024-09-04

o-desmethylindomethacin and haloperidol

o-desmethylindomethacin has been researched along with haloperidol in 2 studies

Compound Research Comparison

Studies
(o-desmethylindomethacin)		Trials
(o-desmethylindomethacin)		Recent Studies (post-2010)
(o-desmethylindomethacin)		Studies
(haloperidol)		Trials
(haloperidol)		Recent Studies (post-2010) (haloperidol)
270420,3301,7533,294

Protein Interaction Comparison

ProteinTaxonomyo-desmethylindomethacin (IC50)haloperidol (IC50)
Adenylate cyclase type 1 Rattus norvegicus (Norway rat)2.3
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)1.7
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.5
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.6765
Potassium channel subfamily K member 2Homo sapiens (human)5.5
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.836
ATP-dependent translocase ABCB1Homo sapiens (human)5.3
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.054
Cytochrome P450 3A4Homo sapiens (human)0.055
5-hydroxytryptamine receptor 1AHomo sapiens (human)1.5
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.1754
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M5Homo sapiens (human)3.89
Alpha-2A adrenergic receptorHomo sapiens (human)4.973
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)2.3
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M1Homo sapiens (human)5.5
Cytochrome P450 2C9 Homo sapiens (human)4.69
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)7
D(2) dopamine receptorHomo sapiens (human)0.0897
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.1467
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0852
Alpha-2B adrenergic receptorHomo sapiens (human)1.354
Alpha-2C adrenergic receptorHomo sapiens (human)1.845
DRattus norvegicus (Norway rat)0.1103
D(3) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4.3045
D(2) dopamine receptorBos taurus (cattle)0.1332
D(1A) dopamine receptorHomo sapiens (human)0.0575
D(4) dopamine receptorHomo sapiens (human)0.0978
D(1B) dopamine receptorHomo sapiens (human)0.005
Adenylate cyclase type 3Rattus norvegicus (Norway rat)2.3
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0852
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.836
Histamine H2 receptorHomo sapiens (human)1.166
Alpha-1D adrenergic receptorHomo sapiens (human)0.084
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.0067
Adenylate cyclase type 2Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 4Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.1815
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.347
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.018
D(4) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.1754
Sodium-dependent serotonin transporterHomo sapiens (human)3.386
Histamine H1 receptorHomo sapiens (human)2.781
Mu-type opioid receptorHomo sapiens (human)2.443
D(3) dopamine receptorHomo sapiens (human)0.0065
Sodium channel protein type 1 subunit alphaHomo sapiens (human)7
Sodium channel protein type 4 subunit alphaHomo sapiens (human)7
Adenylate cyclase type 8Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.05
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0852
Cytochrome P450 2J2Homo sapiens (human)4.69
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0129
N-acetyltransferase EisMycobacterium tuberculosis H37Rv0.39
Sodium channel protein type 7 subunit alphaHomo sapiens (human)7
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.5
Adenylate cyclase type 6Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 5Rattus norvegicus (Norway rat)1.425
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2634
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.5
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.5
Sodium channel protein type 5 subunit alphaHomo sapiens (human)7
Sodium channel protein type 9 subunit alphaHomo sapiens (human)7
Adenylyl cyclase 7 Rattus norvegicus (Norway rat)2.3
DBos taurus (cattle)0.2509
Sodium channel protein type 2 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.07
Sodium channel protein type 3 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Rattus norvegicus (Norway rat)0.0013
Sodium channel protein type 11 subunit alphaHomo sapiens (human)7
Sodium channel protein type 8 subunit alphaHomo sapiens (human)7
Sodium channel protein type 10 subunit alphaHomo sapiens (human)7

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Novotney, S; Yamamoto, BK1
Devoto, P; Flore, G; Gessa, GL; Longu, G; Pira, L1

Other Studies

2 other study(ies) available for o-desmethylindomethacin and haloperidol

ArticleYear
Regulation of extracellular dopamine by the norepinephrine transporter.
    Journal of neurochemistry, 1998, Volume: 71, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Carrier Proteins; Caudate Nucleus; Dopamine; Dopamine Antagonists; Extracellular Space; Haloperidol; Idazoxan; Indomethacin; Male; Microdialysis; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Symporters

1998
Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex.
    Journal of neurochemistry, 2004, Volume: 88, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-2 Receptor Antagonists; Animals; Cerebral Cortex; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Extracellular Space; Haloperidol; Indomethacin; Male; Microdialysis; Neurons; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors

2004