Page last updated: 2024-09-03

o-demethyltramadol and u-50488

o-demethyltramadol has been researched along with u-50488 in 3 studies

Compound Research Comparison

Studies
(o-demethyltramadol)
Trials
(o-demethyltramadol)
Recent Studies (post-2010)
(o-demethyltramadol)
Studies
(u-50488)
Trials
(u-50488)
Recent Studies (post-2010) (u-50488)
15034731,6643209
6031,6643209

Protein Interaction Comparison

ProteinTaxonomyo-demethyltramadol (IC50)u-50488 (IC50)
Delta-type opioid receptorRattus norvegicus (Norway rat)2.15
Kappa-type opioid receptorMus musculus (house mouse)0.0027
Mu-type opioid receptorRattus norvegicus (Norway rat)2.15
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.7171
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0958
Kappa-type opioid receptorHomo sapiens (human)0.0537

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Heller, NM; Maher, DP; Walia, D1
Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP1
Fu, W; Huang, H; Li, W; Liu, J; Wang, W; Wang, Y; Xu, X; Zhu, C1

Other Studies

3 other study(ies) available for o-demethyltramadol and u-50488

ArticleYear
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
    Anesthesia and analgesia, 2019, Volume: 128, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol

2019
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
    Bioorganic & medicinal chemistry letters, 2009, Jan-01, Volume: 19, Issue:1

    Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol

2009
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.
    European journal of medicinal chemistry, 2020, Mar-01, Volume: 189

    Topics: Analgesics; Animals; Female; Ligands; Mice; Models, Molecular; Pain; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

2020