o-demethyltramadol has been researched along with metoprolol in 1 studies
| Studies (o-demethyltramadol) | Trials (o-demethyltramadol) | Recent Studies (post-2010) (o-demethyltramadol) | Studies (metoprolol) | Trials (metoprolol) | Recent Studies (post-2010) (metoprolol) |
|---|---|---|---|---|---|
| 150 | 34 | 73 | 5,821 | 1,743 | 1,304 |
| Protein | Taxonomy | o-demethyltramadol (IC50) | metoprolol (IC50) |
|---|---|---|---|
| Beta-2 adrenergic receptor | Homo sapiens (human) | 2.573 | |
| Beta-1 adrenergic receptor | Homo sapiens (human) | 0.176 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 4.87 | |
| Cytochrome P450 2J2 | Homo sapiens (human) | 4.87 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cicali, B; Cristofoletti, R; Dow, P; Long, T; Michaud, V; Schmidt, S; Turgeon, J | 1 |
1 other study(ies) available for o-demethyltramadol and metoprolol
| Article | Year |
|---|---|
Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6-Mediated Drug-Drug Interactions on Tramadol and O-Desmethyltramadol Exposures via Allosteric and Competitive Inhibition.
Topics: Analgesics, Opioid; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Half-Life; Humans; Metabolic Clearance Rate; Metoprolol; Models, Biological; Quinidine; Tramadol | 2022 |