Page last updated: 2024-09-03

o-demethyltramadol and methadone

o-demethyltramadol has been researched along with methadone in 4 studies

Compound Research Comparison

Studies (o-demethyltramadol)	Trials (o-demethyltramadol)	Recent Studies (post-2010) (o-demethyltramadol)	Studies (methadone)	Trials (methadone)	Recent Studies (post-2010) (methadone)
150	34	73	13,630	1,463	3,957

Protein Interaction Comparison

Protein	Taxonomy	methadone (IC50)
ATP-dependent translocase ABCB1	Homo sapiens (human)	7.5
Mu-type opioid receptor	Homo sapiens (human)	0.0041
Delta-type opioid receptor	Homo sapiens (human)	1.09
Kappa-type opioid receptor	Homo sapiens (human)	0.512
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	9.7724

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	1 (25.00)	2.80

Authors

Authors	Studies
Coller, JK; Colvill, J; Farquharson, AL; James, HM; Michalakas, JR; Somogyi, AA; White, JM	1
Häkkinen, M; Launiainen, T; Ojanperä, I; Vuori, E	1
Heller, NM; Maher, DP; Walia, D	1
Aertgeerts, B; Bertels, X; Bonmariage, P; Boogaerts, T; Covaci, A; De Loof, H; Hamelinck, W; Lahousse, L; Pussig, B; Quireyns, M; Saevels, J; van Nuijs, ALN; Van Wichelen, N	1

Trials

1 trial(s) available for o-demethyltramadol and methadone

Article	Year
Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients. British journal of clinical pharmacology, 2012, Volume: 74, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Tramadol; Young Adult	2012

Article

Year

Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients.

British journal of clinical pharmacology, 2012, Volume: 74, Issue:5

Topics: Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Tramadol; Young Adult

2012

Other Studies

3 other study(ies) available for o-demethyltramadol and methadone

Article	Year
Comparison of fatal poisonings by prescription opioids. Forensic science international, 2012, Oct-10, Volume: 222, Issue:1-3 Topics: Accidents; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Central Nervous System Depressants; Codeine; Dextropropoxyphene; Drug Overdose; Ethanol; Fentanyl; Finland; Forensic Toxicology; Humans; Hypnotics and Sedatives; Methadone; Morphine; Opioid-Related Disorders; Oxycodone; Poisoning; Prescription Drug Misuse; Suicide; Tramadol; Young Adult	2012
Suppression of Human Natural Killer Cells by Different Classes of Opioids. Anesthesia and analgesia, 2019, Volume: 128, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol	2019
Do the lockdown-imposed changes in a wastewater treatment plant catchment's socio-demographics impact longitudinal temporal trends in psychoactive pharmaceutical use? The Science of the total environment, 2023, Jun-10, Volume: 876 Topics: Biomarkers; Citalopram; Communicable Disease Control; COVID-19; Demography; Desvenlafaxine Succinate; Humans; Methadone; Pandemics; Pharmaceutical Preparations; Tramadol; Wastewater; Water Pollutants, Chemical	2023