o-demethyltramadol has been researched along with itraconazole in 1 studies
| Studies (o-demethyltramadol) | Trials (o-demethyltramadol) | Recent Studies (post-2010) (o-demethyltramadol) | Studies (itraconazole) | Trials (itraconazole) | Recent Studies (post-2010) (itraconazole) |
|---|---|---|---|---|---|
| 150 | 34 | 73 | 6,440 | 653 | 2,357 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hagelberg, NM; Laine, K; Neuvonen, M; Neuvonen, PJ; Olkkola, KT; Saari, TI; Saarikoski, T; Scheinin, M; Turpeinen, M | 1 |
1 trial(s) available for o-demethyltramadol and itraconazole
| Article | Year |
|---|---|
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.
Topics: Adult; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Humans; Itraconazole; Kidney; Male; Metabolic Clearance Rate; Oxidoreductases, N-Demethylating; Ticlopidine; Tramadol; Young Adult | 2013 |