Compounds > o-demethyltramadol
Page last updated: 2024-09-03

o-demethyltramadol and fluoxetine

o-demethyltramadol has been researched along with fluoxetine in 1 studies

Compound Research Comparison

Studies
(o-demethyltramadol)		Trials
(o-demethyltramadol)		Recent Studies (post-2010)
(o-demethyltramadol)		Studies
(fluoxetine)		Trials
(fluoxetine)		Recent Studies (post-2010) (fluoxetine)
150347310,1001,6633,263

Protein Interaction Comparison

ProteinTaxonomyo-demethyltramadol (IC50)fluoxetine (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)5.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.119
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.303
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.358
Cytochrome P450 2D6Homo sapiens (human)0.7
Muscarinic acetylcholine receptor M1Homo sapiens (human)3.203
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)5.2
Alpha-2B adrenergic receptorHomo sapiens (human)1.528
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)5.2
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.595
AcetylcholinesteraseHomo sapiens (human)0.13
Prostaglandin G/H synthase 1Homo sapiens (human)6
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.8332
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)6
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.452
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.1395
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)5.2
Sodium-dependent serotonin transporterHomo sapiens (human)0.0342
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0538
Cytochrome P450 2C19Homo sapiens (human)0.0525
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)5.2
5-hydroxytryptamine receptor 6Homo sapiens (human)1.661
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)5.2
Sodium-dependent dopamine transporter Homo sapiens (human)5.984
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.3513
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)5.2
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0094
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)5.2
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.6751
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)5.2

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hou, YN; Liu, HC; Wang, N; Yu, Y1

Other Studies

1 other study(ies) available for o-demethyltramadol and fluoxetine

ArticleYear
Stereoselectivity in trans-tramadol metabolism and trans-O-demethyltramadol formation in rat liver microsomes.
    Acta pharmacologica Sinica, 2003, Volume: 24, Issue:1

    Topics: Analgesics, Opioid; Animals; Dextromethorphan; Fluoxetine; Male; Microsomes, Liver; Propafenone; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol

2003