o-demethylmetoprolol has been researched along with metoprolol in 8 studies
| Studies (o-demethylmetoprolol) | Trials (o-demethylmetoprolol) | Recent Studies (post-2010) (o-demethylmetoprolol) | Studies (metoprolol) | Trials (metoprolol) | Recent Studies (post-2010) (metoprolol) |
|---|---|---|---|---|---|
| 8 | 0 | 3 | 5,821 | 1,743 | 1,304 |
| Protein | Taxonomy | o-demethylmetoprolol (IC50) | metoprolol (IC50) |
|---|---|---|---|
| Beta-2 adrenergic receptor | Homo sapiens (human) | 2.573 | |
| Beta-1 adrenergic receptor | Homo sapiens (human) | 0.176 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 4.87 | |
| Cytochrome P450 2J2 | Homo sapiens (human) | 4.87 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Högstedt, S; Lindberg, B; Peng, DR; Rane, A; Regårdh, CG | 1 |
| Jack, DB; Kendall, MJ; Quarterman, CP | 1 |
| Ackland, MJ; Ellis, SW; Lennard, MS; Rekka, E; Rowland, K; Simula, AP; Tucker, GT; Wolf, CR | 1 |
| Boralli, VB; Cerqueira, PM; Coelho, EB; Lanchote, VL | 1 |
| Chen, X; Jiang, H; Liang, X | 1 |
| Brewer, S; Donkor, K; Elizalde-Velázquez, A; Galar-Martínez, M; Gómez-Oliván, LM; Islas-Flores, H; Martínez-Rodríguez, H; Sánchez-Aceves, L; SanJuan-Reyes, N | 1 |
| Bourgogne, E; Delhotal-Landes, B; Gourlain, H; Labat, L; Leclercq, M; Mégarbane, B; Soichot, M | 1 |
| Gu, J; Jin, L; Lam, PKS; Ruan, Y; Wang, Q; Yan, M; Zhang, K | 1 |
8 other study(ies) available for o-demethylmetoprolol and metoprolol
| Article | Year |
|---|---|
Pregnancy-induced increase in metoprolol metabolism.
Topics: Adult; Blood Proteins; Female; Humans; Hypertension; Kinetics; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Protein Binding; Time Factors | 1985 |
The effect of age on the pharmacokinetics of metoprolol and its metabolites.
Topics: Adolescent; Adult; Aged; Aging; Chemical Phenomena; Chemistry; Female; Humans; Kinetics; Metoprolol; Middle Aged; Propanolamines | 1981 |
Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.
Topics: Amino Acid Sequence; Binding Sites; Cloning, Molecular; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Humans; Kinetics; Metoprolol; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Protein Structure, Secondary; Saccharomyces cerevisiae; Sequence Alignment; Spectrophotometry; Stereoisomerism | 1996 |
Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism.
Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Circular Dichroism; Half-Life; Male; Metoprolol; Rats; Rats, Wistar; Reproducibility of Results; Stereoisomerism | 2005 |
Human DBS sampling with LC-MS/MS for enantioselective determination of metoprolol and its metabolite O-desmethyl metoprolol.
Topics: Blood Chemical Analysis; Blood Specimen Collection; Blood Volume; Chromatography, Liquid; Desiccation; Drug Stability; Humans; Linear Models; Metoprolol; Quality Control; Stereoisomerism; Tandem Mass Spectrometry; Temperature | 2010 |
Metoprolol induces oxidative damage in common carp (Cyprinus carpio).
Topics: Animals; Antioxidants; Biomarkers; Carps; Catalase; Electrophoresis, Capillary; Gills; Hydrogen Peroxide; Kidney; Lipid Peroxidation; Liver; Metoprolol; Organ Specificity; Oxidation-Reduction; Oxidative Stress; Protein Carbonylation; Superoxide Dismutase; Water Pollutants, Chemical | 2018 |
False positive amphetamines and 3,4-methylenedioxymethamphetamine immunoassays in the presence of metoprolol-two cases reported in clinical toxicology.
Topics: Adult; Amphetamine; Amphetamines; Cross Reactions; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Immunoenzyme Techniques; Male; Methamphetamine; Metoprolol; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Substance Abuse Detection | 2020 |
Enantiospecific Uptake and Depuration Kinetics of Chiral Metoprolol and Venlafaxine in Marine Medaka (
Topics: Animals; Metoprolol; Oryzias; Pharmaceutical Preparations; Tissue Distribution; Venlafaxine Hydrochloride | 2023 |