o-demethylencainide has been researched along with encainide in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (73.08) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Altemeier, WA; Roden, DM; Turgeon, J; Wikswo, JP; Wisialowski, TA; Wong, W | 1 |
| Destache, CJ; Hilleman, DE; Malesker, MA; Mohiuddin, SM; Nipper, HC; Stoysich, AM | 1 |
| Halstenson, CE; Halvorsen, MB; Whitmer, JT | 1 |
| Antonaccio, MJ; Buchanan, JO; Fleming, JS; Iben, LG; Yocca, FD | 1 |
| Caron, J; Libersa, C; Rouet, R | 1 |
| Cheymol, G; Lebot, M; Poirier, JM | 1 |
| Barnay, C; Cheymol, G; Coumel, P; Dumoulin, P; Flammang, D; Jaillon, P; Kher, A; Medvedowsky, JL; Poirier, JM; Valty, J | 1 |
| Mason, JW | 1 |
| Anno, T; Bennett, PB; Hondeghem, LM; Johns, JA; Snyders, DJ | 1 |
| Campbell, TJ; Hemsworth, PD | 1 |
| Kinnaird, AA; Man, RY | 1 |
| Bajaj, AK; Roden, DM; Woosley, RL | 1 |
| Altenbern, D; Dai, GH; Oates, J; Roden, DM; Wang, T; Wilkinson, GR; Woosley, RL | 1 |
| Davy, JM; Dorian, P; Fain, ES; Kates, RE; Winkle, RA | 1 |
| Davy, JM; Dorian, P; Harrison, DC; Kantelip, JP; Kates, RE | 1 |
| Antonaccio, MJ; Verjee, S | 1 |
| Roden, DM; Wilkinson, GR; Wood, AJ; Woosley, RL | 1 |
| Harrison, DC; Kates, RE; Quart, BD | 1 |
| Barbey, JT; Echt, DS; Roden, DM; Thompson, KA; Woosley, RL | 1 |
| Dresel, PE | 1 |
| Carey, EL; Duff, HJ; Oates, JA; Primm, RK; Roden, DM; Wang, T; Wilkinson, GR; Woosley, RL | 1 |
| Dawson, AK; Duff, HJ; Roden, DM; Smith, RF; Woosley, RL | 1 |
| Elharrar, V; Zipes, DP | 1 |
| Altenbern, D; Duff, HJ; Roden, DM; Woosley, RL | 1 |
| Dawson, AK; Duff, HJ; Oates, JA; Roden, DM; Smith, RF; Woosley, RL | 1 |
| Chiamvimonvat, N; Duff, HJ; Wang, L | 1 |
3 review(s) available for o-demethylencainide and encainide
| Article | Year |
|---|---|
In-vitro and in-vivo electrophysiologic effects of encainide.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Electrocardiography; Encainide; Female; Guinea Pigs; Heart Conduction System; Humans; In Vitro Techniques; Male | 1990 |
Basic and clinical cardiac electrophysiology of encainide.
Topics: Action Potentials; Anilides; Animals; Electrocardiography; Electrophysiology; Encainide; Heart; Humans; Ion Channels; Sodium | 1986 |
Disposition kinetics of encainide and metabolites.
Topics: Anilides; Arrhythmias, Cardiac; Biological Availability; Biotransformation; Encainide; Female; Humans; Kidney Diseases; Kinetics; Liver; Liver Cirrhosis; Pregnancy | 1986 |
4 trial(s) available for o-demethylencainide and encainide
| Article | Year |
|---|---|
Impact of food on the bioavailability of encainide.
Topics: Adult; Biological Availability; Drug Administration Schedule; Encainide; Fasting; Food; Humans; Male | 1992 |
Long-term efficacy and safety of oral encainide in the treatment of chronic ventricular ectopic activity: relationship to plasma concentrations--a French multicenter trial.
Topics: Adolescent; Adult; Aged; Anilides; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Chronic Disease; Clinical Trials as Topic; Electrocardiography; Encainide; Female; France; Heart Ventricles; Humans; Male; Middle Aged | 1985 |
Dosing recommendations for encainide.
Topics: Anilides; Arrhythmias, Cardiac; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Encainide; Heart Ventricles; Humans; Kinetics; Random Allocation | 1986 |
Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man.
Topics: Adult; Aged; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Encainide; Female; Humans; Male; Middle Aged | 1988 |
19 other study(ies) available for o-demethylencainide and encainide
| Article | Year |
|---|---|
Suppression of longitudinal versus transverse conduction by sodium channel block. Effects of sodium bolus.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Encainide; Female; Heart Conduction System; Male; Sodium Channels; Sodium Chloride | 1992 |
Hemodialysis clearance of encainide and metabolites.
Topics: Adult; Anti-Arrhythmia Agents; Encainide; Humans; Kidney Failure, Chronic; Male; Renal Dialysis | 1991 |
Effect of encainide, ODE, MODE, and flecainide on ADP/5-HT induced platelet aggregation and in the anesthetized dog coronary artery stenosis-occlusion model of intravascular thrombosis.
Topics: Adenosine Diphosphate; Anilides; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Coronary Thrombosis; Disease Models, Animal; Dogs; Encainide; Flecainide; Heart Rate; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Ventricular Function, Left | 1991 |
Analysis of encainide and its three major metabolites in plasma by column liquid chromatography.
Topics: Anilides; Anti-Arrhythmia Agents; Calibration; Chromatography, Liquid; Encainide; Humans | 1990 |
Temperature and voltage dependence of sodium channel blocking and unblocking by O-demethyl encainide in isolated guinea pig myocytes.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Electrophysiology; Encainide; Guinea Pigs; In Vitro Techniques; Myocardium; Sodium Channels; Temperature; Time Factors | 1989 |
Depression of maximum rate of depolarization of guinea-pig ventricular action potentials by metabolites of encainide.
Topics: Action Potentials; Anilides; Animals; Anti-Arrhythmia Agents; Dogs; Electric Stimulation; Encainide; Female; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Muscle, Smooth, Vascular | 1989 |
Electrophysiological effects of encainide and its metabolites in normal canine Purkinje fibers and Purkinje fibers surviving infarction.
Topics: Action Potentials; Anilides; Animals; Anti-Arrhythmia Agents; Dogs; Encainide; Female; Heart Conduction System; In Vitro Techniques; Male; Myocardial Infarction; Purkinje Fibers | 1989 |
Acute electrophysiologic effects of sodium administration in dogs treated with O-desmethyl encainide.
Topics: Alkalosis, Respiratory; Anilides; Animals; Bicarbonates; Dogs; Electroencephalography; Electrophysiology; Encainide; Female; Heart; Heart Conduction System; Heart Rate; Hyperventilation; Male; Sodium; Sodium Bicarbonate; Sodium Chloride; Time Factors | 1989 |
Co-inheritance of the polymorphic metabolism of encainide and debrisoquin.
Topics: Administration, Oral; Adult; Aged; Anilides; Chromatography, High Pressure Liquid; Debrisoquin; Electrocardiography; Encainide; Female; Half-Life; Humans; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype | 1986 |
Effects of encainide and its metabolites on energy requirements for defibrillation.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Electrocardiography; Electrodes, Implanted; Encainide; Female; Male; Tachycardia; Time Factors | 1986 |
Qualitative and quantitative comparison of the cardiac effects of encainide and its three major metabolites in the dog.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Encainide; Female; Heart; Male; Refractory Period, Electrophysiological | 1986 |
Relation of blood level and metabolites to the antiarrhythmic effectiveness of encainide.
Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biotransformation; Circadian Rhythm; Dose-Response Relationship, Drug; Encainide; Heart Ventricles; Humans; Kinetics; Myocardial Contraction; Time Factors | 1986 |
Effect of encainide and its two major metabolites on cardiac conduction.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Bundle of His; Dogs; Encainide; Female; Heart Conduction System; In Vitro Techniques; Male; Membrane Potentials; Purkinje Fibers; Rabbits | 1984 |
Encainide and its metabolites. Comparative effects in man on ventricular arrhythmia and electrocardiographic intervals.
Topics: Aged; Anilides; Arrhythmias, Cardiac; Electrocardiography; Encainide; Female; Heart; Heart Ventricles; Humans; Kinetics; Male; Middle Aged; Regression Analysis | 1984 |
Differential effects of O-demethyl encainide on induced and spontaneous arrhythmias in the conscious dog.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Encainide; Myocardial Infarction; Ventricular Fibrillation | 1984 |
Effects of encainide and metabolites (MJ14030 and MJ9444) on canine cardiac Purkinje and ventricular fibers.
Topics: Action Potentials; Anilides; Animals; Anti-Arrhythmia Agents; Biotransformation; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Encainide; Heart; Heart Ventricles; Microelectrodes; Purkinje Fibers | 1982 |
Antiarrhythmic activity of the O-demethyl metabolite of encainide.
Topics: Aconitine; Anilides; Animals; Anti-Arrhythmia Agents; Dealkylation; Digestive System Physiological Phenomena; Encainide; Heart Conduction System; Heart Rate; Liver; Male; Procainamide; Rats; Rats, Inbred Strains | 1982 |
Electrophysiologic actions of O-demethyl encainide: an active metabolite.
Topics: Action Potentials; Anilides; Animals; Dogs; Electrocardiography; Encainide; Heart; Infusions, Parenteral; Kinetics | 1983 |
Interaction between selected sodium and potassium channel blockers in guinea pig papillary muscle.
Topics: Action Potentials; Animals; Barium; Barium Compounds; Chlorides; Encainide; Female; Guinea Pigs; In Vitro Techniques; Male; Mexiletine; Papillary Muscles; Potassium Channels; Refractory Period, Electrophysiological; Sodium Channels | 1993 |