o-(6)-methylguanine has been researched along with o(6)-benzylguanine in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (50.00) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dolan, ME; McDougall, MG; Moschel, RC; Pegg, AE; Stine, L | 1 |
| Arris, CE; Bleasdale, C; Boyle, FT; Calvert, AH; Curtin, NJ; Dalby, C; Golding, BT; Griffin, RJ; Kanugula, S; Lembicz, NK; Newell, DR; Pegg, AE | 1 |
| Arris, CE; Bentley, J; Boyle, FT; Curtin, NJ; Davies, TG; Endicott, JA; Gibson, AE; Golding, BT; Grant, S; Griffin, RJ; Jewsbury, P; Johnson, LN; Mesguiche, V; Newell, DR; Noble, ME; Tucker, JA; Whitfield, HJ | 1 |
| Caflisch, A; Dey, F; Huang, D; Kolb, P | 1 |
| Bigner, DD; Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Pegg, AE; Rich, J; Schold, SC | 1 |
| Beattie, C; Guzman, RC; Hamdan, MA; Mascharack, P; Nandi, S; Yang, J | 1 |
| Dolan, ME; Dumenco, LL; Gerson, SL; Moschel, RC; Pegg, AE | 1 |
| Dolan, ME; Moschel, RC; Pegg, AE | 1 |
| Ikenaga, M; Izumi, I; Kohda, K; Kowada, M; Mineura, K; Watanabe, K | 1 |
| Hughes, SH; Moschel, RC; Pauly, GT | 1 |
| Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME | 1 |
| Ikenaga, M; Izumi, I; Kohda, K; Kowada, M; Koyama, K; Mineura, K; Terashima, I; Watanabe, K | 1 |
| O'Toole, SM; Pegg, AE; Swenberg, JA | 1 |
| Bishop, RE; Dolan, ME; Dunn, LL; Moschel, RC; Pauly, GT | 1 |
| Bhattacharyya, NP; Maher, VM; McCormick, JJ; Tsujimura, T; Zhang, H | 1 |
| Gerson, SL; Liu, L; Markowitz, S | 1 |
| Armstrong, MJ; Galloway, SM | 1 |
| Kooistra, R; Lohman, PH; Margison, GP; Pastink, A; Watson, AJ; Zonneveld, JB | 1 |
| Encell, LP; Loeb, LA | 1 |
| Boley, SE; Maher, VM; McCormick, JJ; McManus, TP | 1 |
| Daniels, DS; Tainer, JA | 1 |
| Moschel, RC; Pauly, GT | 1 |
| Crankshaw, DL; Donaldson, EE; Kenney, PJ; Peterson, LA; Thomson, NM | 1 |
| Guengerich, FP; Woodside, AM | 2 |
| Biswas, K; Chang, S; Haines, DC; Kaldis, P; Kanugula, S; Kuznetsov, SG; Loktionova, NA; Pegg, AE; Philip, S; Sharan, SK; Swaminathan, S | 1 |
| Coffey, M; Hollywood, D; Lawler, M; Marignol, L; Marples, B; Martin, L | 1 |
| Jin, YH; Liu, HY; Shu, F; Wang, QJ; Wang, Z; Yang, Y; Zhang, WB | 1 |
| Boby, ML; Gahlon, HL; Sturla, SJ | 1 |
| Marx, A; Nilforoushan, A; Sturla, SJ; Williams, DM; Wyss, LA | 1 |
1 review(s) available for o-(6)-methylguanine and o(6)-benzylguanine
| Article | Year |
|---|---|
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase.
Topics: Alkylation; Amino Acid Sequence; Amino Acid Substitution; Archaeal Proteins; Arginine; Bacterial Proteins; Binding Sites; Cysteine; DNA Damage; DNA Repair; Evolution, Molecular; Guanine; Helix-Turn-Helix Motifs; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Protein Binding; Protein Conformation; Sequence Alignment; Sequence Homology, Amino Acid | 2000 |
29 other study(ies) available for o-(6)-methylguanine and o(6)-benzylguanine
| Article | Year |
|---|---|
Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase.
Topics: DNA Repair; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Purines; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
Topics: Antineoplastic Agents, Alkylating; Cell Extracts; Dacarbazine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Temozolomide; Tumor Cells, Cultured | 2000 |
Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Division; Crystallography, X-Ray; Cyclin A; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Guanine; Humans; Models, Molecular; Protein Serine-Threonine Kinases; Ribose; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model.
Topics: Humans; Models, Molecular; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Quantitative Structure-Activity Relationship; Static Electricity; Thermodynamics | 2008 |
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
Topics: Animals; Carmustine; Drug Resistance; Female; Glioblastoma; Guanine; Humans; Male; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous | 1992 |
Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells.
Topics: Animals; Base Sequence; Breast; Cell Transformation, Neoplastic; Cells, Cultured; Collagen; Culture Media; Epithelial Cells; Epithelium; Female; Guanine; Humans; Menopause; Methyltransferases; Mice; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1992 |
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.
Topics: Animals; Bacterial Proteins; CHO Cells; Cricetinae; DNA; Enzyme Activation; Escherichia coli Proteins; Guanine; Humans; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors; Transfection | 1991 |
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Drug Synergism; Guanine; Humans; Kidney; Kinetics; Liver; Lomustine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Basal Ganglia; Brain Neoplasms; Cell Count; Cell Division; Culture Techniques; DNA Repair; DNA, Neoplasm; Drug Synergism; Glioma; Guanine; Male; Nimustine; Rats; Rats, Wistar | 1994 |
Response of repair-competent and repair-deficient Escherichia coli to three O6-substituted guanines and involvement of methyl-directed mismatch repair in the processing of O6-methylguanine residues.
Topics: Base Sequence; Codon; DNA Repair; DNA Replication; Escherichia coli; Genes, Bacterial; Guanine; Methyltransferases; Models, Genetic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Plasmids | 1994 |
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathione; Glutathione Transferase; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1994 |
Enhancing effect of O6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells.
Topics: Animals; Brain Neoplasms; Cell Survival; Drug Synergism; Guanine; HeLa Cells; Humans; Nimustine; Rats; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; DNA; DNA Repair; Guanine; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344; Thymidine | 1993 |
The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
Topics: Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Codon; DNA Damage; DNA Repair; Genes, ras; Guanine; Methyltransferases; Molecular Sequence Data; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Transfection | 1993 |
O6-methylguanine induces intrachromosomal homologous recombination in human cells.
Topics: Cells, Cultured; Cinnamates; DNA Adducts; Gene Conversion; Guanine; Humans; Hygromycin B; Methylnitronitrosoguanidine; Recombination, Genetic; Thymidine Kinase | 1996 |
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents.
Topics: Alkylating Agents; Animals; Cell Division; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Enzyme Inhibitors; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Thioguanine | 1997 |
Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Repair; DNA, Complementary; Drosophila melanogaster; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thymine; Transcription Factors | 1999 |
Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.
Topics: DNA Damage; DNA Repair; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Lac Operon; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Point Mutation; Substrate Specificity; Thymine | 2000 |
Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination.
Topics: Alleles; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Codon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Genes, p53; Guanine; Homozygote; Humans; Loss of Heterozygosity; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Transcriptional Activation | 2000 |
Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.
Topics: Base Pair Mismatch; Colonic Neoplasms; Escherichia coli; Genetic Vectors; Guanine; Humans; Kidney; Lac Operon; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Transfection | 2001 |
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2001 |
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine.
Topics: Antineoplastic Agents; Carcinogens; Deoxyribonucleotides; DNA Primers; DNA-Directed DNA Polymerase; Guanine; HIV Reverse Transcriptase; Kinetics; Substrate Specificity; Templates, Genetic | 2002 |
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes.
Topics: Carcinogens; Deoxyribonucleotides; DNA Adducts; DNA Replication; DNA-Directed DNA Polymerase; Guanine; HIV Reverse Transcriptase; Kinetics; Models, Theoretical; Oligodeoxyribonucleotides; Recombinant Proteins; Substrate Specificity | 2002 |
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.
Topics: Alkylating Agents; Amino Acid Sequence; Animals; BRCA2 Protein; DNA Repair; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Mice; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase | 2008 |
Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.
Topics: Cell Division; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Mismatch Repair; Drug Resistance, Neoplasm; Enzyme Activation; G2 Phase; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Radiation Dosage; Radiation Tolerance; Temozolomide | 2009 |
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mechanistic Target of Rapamycin Complex 1; Methylnitronitrosoguanidine; Multiprotein Complexes; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2010 |
O6-alkylguanine postlesion DNA synthesis is correct with the right complement of hydrogen bonding.
Topics: Archaeal Proteins; Base Pairing; DNA Adducts; DNA Damage; DNA Polymerase beta; DNA Repair; DNA Replication; DNA, Archaeal; Gene Expression; Guanine; Hydrogen Bonding; Recombinant Proteins; Sulfolobus solfataricus | 2014 |
The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts.
Topics: Base Pairing; Carcinogens; DNA; DNA Adducts; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Kinetics; Models, Molecular; Nucleotides; Reproducibility of Results; Taq Polymerase; Templates, Genetic | 2016 |