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o-(6)-methylguanine and methylnitronitrosoguanidine

o-(6)-methylguanine has been researched along with methylnitronitrosoguanidine in 94 studies

Research

Studies (94)

Timeframe	Studies, this research(%)	All Research%
pre-1990	47 (50.00)	18.7374
1990's	25 (26.60)	18.2507
2000's	14 (14.89)	29.6817
2010's	8 (8.51)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Day, RS	1
Erickson, LC	1
Georgiadis, P; Smith, CA; Swann, PF	1
Dunn, WC; Horesovsky, GJ; Mitra, S; Preston, RJ; Tano, K	1
Hutchinson, F; Romac, S; Sockett, H	1
Ebisuzaki, K; Kalamegham, R	1
Hayakawa, H; Koike, G; Sekiguchi, M	1
Samson, L; Sassanfar, M	1
Laval, F; Lefebvre, P	2
D'Ambrosio, SM; Gibson-D'Ambrosio, R; Lowder, E; Samuel, M; Wani, AA; Wani, G	1
Goad, DL; Rebeck, GW; Samson, L; Smith, CM	1
Clyde, C; Dolan, ME; Erickson, LC; Hora, NK; Norbeck, L; Pegg, AE	1
Barrows, LR; Borchers, AH; Paxton, MB	1
Abbondandolo, A; Bignami, M; Calcagnile, A; Dogliotti, E; Frosina, G; Terlizzese, M; Zijno, A	1
Brdar, B; Matulić, M	1
Babich, MA; Day, RS; Scudiero, DA; Yarosh, DB	1
Hall, J; Karran, P; Kataoka, H; Stephenson, C	1
Essigmann, JM; Green, CL; Loechler, EL	1
Teo, IA	1
Goth-Goldstein, R	1
Babich, MA; Day, RS	1
Dunn, WC; Foote, RS; Hand, RE; Mitra, S	1
Hill-Perkins, M; Jones, MD; Karran, P	1
Fujio, C; Ikenaga, M; Ishizaki, K; Nakabeppu, Y; Sekiguchi, M; Tsujimura, T; Yawata, H	1
Laval, F	1
Linn, S; Samson, L	1
Day, RS; DiPaolo, JA; Doniger, J	1
Morohoshi, F; Munakata, N	1
Abbondandolo, A; Frosina, G	1
Karran, P; Williams, SA	1
Corsico, CD; Dolan, ME; Pegg, AE	1
Dolan, ME; Domoradzki, J; Maher, VM; McCormick, JJ; Pegg, AE	1
Karran, P; Lindahl, T	1
Cao, EH; Delihas, NC; Setlow, RB	1
Foote, RS; Hadden, CT; Mitra, S	1
Kleihues, P; Kobori, O; Masako, M; Morioka, Y; Wiestler, O	1
Day, RS; Yagi, T; Yarosh, DB	1
Day, RS; Foote, RS; Mitra, S; Yarosh, DB	1
Sklar, RM; Strauss, BS	1
Cao, EH; Setlow, RB; Waldstein, EA	2
Mace, R; Swann, PF	1
Foote, RS; Mitra, S; Pal, BC	1
Sklar, R; Strauss, B	1
Karran, P; Marinus, MG	1
Guttenplan, JB; Milstein, S	1
Villani, G	1
Karran, P; Teo, IA	1
Giercksky, KE; Krokan, H; Myrnes, B	1
Becker, Y; Shiloh, Y	1
Brady, K; Sklar, R; Strauss, B	1
Grisham, JW; Kaufman, DG; Smith, GJ	1
Lawley, PD; Medcalf, AS	1
Day, RS; Mirzayans, R; Paterson, MC; Rasouli-Nia, A	1
Ihara, K; Kawate, H; Kohda, K; Sakumi, K; Sekiguchi, M	1
Bawa, S; Fontanie, T; Rathgeber, L; Xiao, W	1
Bean, CL; Bradt, CI; Galloway, SM; Greenwood, SK; Hill, RB	1
Nohmi, T; Sedgwick, B; Sofuni, T; Yamada, M	1
Denizeau, F; Fournier, M; Krzystyniak, K; Lachapelle, M; Marion, M	1
Hu, MC; Lin, JG; Wu, CW; Yang, JL	1
Bhattacharyya, NP; Maher, VM; McCormick, JJ; Tsujimura, T; Zhang, H	1
Dosch, J; Kaina, B	1
Dunman, PM; Humayun, MZ; Murphy, HS; Rahman, MS; Wang, G	1
Armstrong, MJ; Galloway, SM	1
Coquerelle, T; Kaina, B; Ochs, K; Ziouta, A	1
Kaina, B	1
Edara, S; Kanugula, S; Pegg, AE	1
Kooistra, R; Lohman, PH; Margison, GP; Pastink, A; Watson, AJ; Zonneveld, JB	1
Aquilina, G; Bignami, M; Crompton, NE; Jiricny, J; Lettieri, T; Marra, G; Palombo, F	1
Aquilina, G; Bignami, M; Karran, P; O'Driscoll, M	1
Encell, LP; Loeb, LA	1
Christmann, M; Kaina, B	1
Jiricny, J; Maher, VM; Marra, G; McCormick, JJ; Zhang, H	1
Haracska, L; Prakash, L; Prakash, S	1
Kaina, B; Ochs, K	1
Loktionova, NA; Nitiss, JL; Pegg, AE; Pommier, Y; Pourquier, P; Urasaki, Y; Waltman, JL	1
Glover, CL; Goodluck-Griffith, J; Ling, LL; Thilly, WG; Tomita-Mitchell, A	1
Baumgartner, M; Kaina, B; Roos, W	1
Cairns, J; Robins, P	1
Griffin, B; Karran, P; Lindahl, T	1
Ferguson, J; Margison, GP; Pearson, SJ; Santibanez-Koref, M	1
Batista, LF; Kaina, B; Menck, CF; Naumann, SC; Roos, WP; Weller, M; Wick, W	1
Christmann, M; Fraser, ST; Kaina, B; Roos, WP	1
Mitra, S	1
Biswas, K; Chang, S; Haines, DC; Kaldis, P; Kanugula, S; Kuznetsov, SG; Loktionova, NA; Pegg, AE; Philip, S; Sharan, SK; Swaminathan, S	1
Kaina, B; Quiros, S; Roos, WP	1
Pittman, DL; Rajesh, C; Rajesh, P; Wyatt, MD	1
Dianov, GL; Digweed, M; Eich, M; Kaina, B; Roos, WP	1
Jin, YH; Liu, HY; Shu, F; Wang, QJ; Wang, Z; Yang, Y; Zhang, WB	1
Kuramitsu, S; Masui, R; Morino, K; Morita, R; Ohta, T; Onodera, T; Tokishita, S	1
Arvai, AS; Butt, A; Latypov, VF; Margison, GP; Marriott, AS; McGown, G; Millington, CL; Povey, AC; Santibanez-Koref, MF; Senthong, P; Tainer, JA; Thorncroft, M; Tubbs, JL; Watson, AJ; Wilkinson, OJ; Williams, DM	1
Eich, M; Kaina, B; Nikolova, T; Roos, WP	1
Aasland, D; Fuchs, RP; Kaina, B; Margison, GP; Modesti, M; Pinder, SI; Tomaszowski, KH; Williams, E	1

Reviews

7 review(s) available for o-(6)-methylguanine and methylnitronitrosoguanidine

Article	Year
The role of O-6 methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibition. Seminars in cancer biology, 1991, Volume: 2, Issue:4 Topics: Animals; DNA Repair; Drug Resistance; Ethylnitrosourea; Guanine; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Rats; Streptozocin	1991
The role of O6-methylguanine in human cell killing, sister chromatid exchange induction and mutagenesis: a review. Journal of cell science. Supplement, 1987, Volume: 6 Topics: Adenoviridae; Base Composition; Cell Survival; DNA Repair; DNA, Viral; Guanine; Humans; Methylnitronitrosoguanidine; Mutation; Sister Chromatid Exchange	1987
The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures. Mutation research, 1985, Volume: 154, Issue:2 Topics: Alkylating Agents; Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Haplorhini; Kidney; Liver; Mammals; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mice; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Placenta; Rats	1985
Enzymology of repair of DNA adducts produced by N-nitroso compounds. IARC scientific publications, 1984, Issue:57 Topics: Alkylation; Animals; Base Sequence; Cells, Cultured; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Nitroso Compounds	1984
[Molecular mechanisms of adaptation of cells to low levels of carcinogenic agents (author's transl)]. Pathologie-biologie, 1982, Volume: 30, Issue:2 Topics: Adaptation, Physiological; Alkylating Agents; Alkylation; Animals; Carcinogens; DNA, Bacterial; Escherichia coli; Eukaryotic Cells; Fibroblasts; Guanine; Humans; Methylnitronitrosoguanidine; Mutation; Rats	1982
Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents. Mutation research, 2000, Volume: 462, Issue:2-3 Topics: Alkylating Agents; Animals; Cell Survival; DNA; DNA Damage; DNA Repair; Guanine; Humans; Mesylates; Methylnitronitrosoguanidine; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured	2000
MGMT: a personal perspective. DNA repair, 2007, Aug-01, Volume: 6, Issue:8 Topics: Alkylating Agents; Animals; Cloning, Molecular; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Escherichia coli; Guanine; History, 20th Century; History, 21st Century; Humans; Methylnitronitrosoguanidine; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Tumor Suppressor Proteins	2007

Other Studies

87 other study(ies) available for o-(6)-methylguanine and methylnitronitrosoguanidine

Article	Year
Incision at O6-methylguanine:thymine mispairs in DNA by extracts of human cells. Biochemistry, 1992, Sep-01, Volume: 31, Issue:34 Topics: Base Composition; Base Sequence; Binding, Competitive; Colonic Neoplasms; Deoxyribonuclease I; DNA; DNA Repair; Glioma; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Tumor Cells, Cultured	1992
Nitrosamine-induced cancer: selective repair and conformational differences between O6-methylguanine residues in different positions in and around codon 12 of rat H-ras. Cancer research, 1991, Nov-01, Volume: 51, Issue:21 Topics: Animals; Bacterial Proteins; Base Composition; Base Sequence; Codon; DNA Repair; Escherichia coli; Escherichia coli Proteins; Genes, ras; Guanine; Kinetics; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Rats; Skin Neoplasms; Thermodynamics; Transcription Factors	1991
The role of O6-alkylguanine in cell killing and mutagenesis in Chinese hamster ovary cells. Carcinogenesis, 1991, Volume: 12, Issue:1 Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Cricetinae; DNA Repair; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Transfection	1991
Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells. Molecular & general genetics : MGG, 1991, Volume: 227, Issue:2 Topics: Animals; Cell Line; DNA Repair; Escherichia coli; Genes, Bacterial; Guanine; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenesis; Plasmids; Polymerase Chain Reaction	1991
O6-methylguanine (O6-MeG) and cytotoxicity: reversion analysis involving an N-methyl-N'-nitro-N-nitrosoguanidine-sensitive, O6-MeG-DNA methyltransferase-deficient HeLa cell mutant. Carcinogenesis, 1990, Volume: 11, Issue:5 Topics: Cell Survival; Clone Cells; DNA Damage; DNA Repair; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Purines	1990
Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA. Journal of molecular biology, 1990, Jun-20, Volume: 213, Issue:4 Topics: Base Sequence; Cloning, Molecular; DNA; DNA Modification Methylases; DNA Repair; Electrophoresis, Polyacrylamide Gel; Guanine; HeLa Cells; Humans; Hygromycin B; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Restriction Mapping; Sequence Homology, Nucleic Acid; Transfection; Transformation, Genetic	1990
Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae. The Journal of biological chemistry, 1990, Jan-05, Volume: 265, Issue:1 Topics: Cysteine; DNA Repair; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanine; Half-Life; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Substrate Specificity; Temperature	1990
Enhancement of O6-methylguanine-DNA-methyltransferase activity induced by various treatments in mammalian cells. Cancer research, 1986, Volume: 46, Issue:11 Topics: Animals; Bleomycin; Cell Cycle; Cells, Cultured; Cisplatin; Cricetinae; DNA; Ellipticines; Enzyme Induction; Gamma Rays; Guanine; Hot Temperature; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Protein Biosynthesis; Rats; Ultraviolet Rays	1986
Absence of DNA damage-mediated induction of human methyltransferase specific for precarcinogenic O6-methylguanine. Teratogenesis, carcinogenesis, and mutagenesis, 1989, Volume: 9, Issue:5 Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA Repair; Female; Fetus; Guanine; Humans; Kidney; Liver; Methylnitronitrosoguanidine; Methyltransferases; Pregnancy; Rats	1989
Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium. Journal of bacteriology, 1989, Volume: 171, Issue:9 Topics: Cysteine; DNA Repair; Escherichia coli; Guanine; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase; Salmonella typhimurium	1989
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents. Carcinogenesis, 1989, Volume: 10, Issue:9 Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Line; Cricetinae; Cricetulus; Female; Guanine; Kinetics; Lomustine; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mitoguazone; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transfection	1989
Transfectant CHO cells expressing O6-alkylguanine-DNA-alkyltransferase display increased resistance to DNA damage other than O6-guanine alkylation. Carcinogenesis, 1987, Volume: 8, Issue:12 Topics: Alkylation; Animals; Carmustine; Cell Survival; Cricetinae; Cricetulus; Deoxyribonuclease BamHI; Deoxyribonuclease EcoRI; DNA Damage; DNA Restriction Enzymes; Guanine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sulfuric Acid Esters; Thioguanine; Transfection; Ultraviolet Rays	1987
Cytotoxicity, mutations and SCEs induced by methylating agents are reduced in CHO cells expressing an active mammalian O6-methylguanine-DNA methyltransferase gene. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: 4-Nitroquinoline-1-oxide; Alkylation; Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Guanine; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Ouabain; Sister Chromatid Exchange	1987
Induction of plasminogen activator by N-methyl-N'-nitro-N-nitrosoguanidine in mer+ and mer- human tumour cell strains. Carcinogenesis, 1988, Volume: 9, Issue:12 Topics: Alkylation; Cell Cycle; DNA; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Plasminogen Activators; Tumor Cells, Cultured	1988
The contribution of O6-methylguanine and methylphosphotriesters to the cytotoxicity of alkylating agents in mammalian cells. Carcinogenesis, 1988, Volume: 9, Issue:9 Topics: Alkylating Agents; Animals; Cell Line; Cloning, Molecular; Cricetinae; DNA Damage; DNA Repair; Drug Resistance; Guanine; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Organophosphates; Organophosphorus Compounds; Structure-Activity Relationship; Transfection	1988
Genetic toxicology of O6 methylguanine. Progress in clinical and biological research, 1986, Volume: 209A Topics: Coliphages; DNA Repair; DNA, Single-Stranded; Escherichia coli; Genes; Guanine; Mathematics; Methylnitronitrosoguanidine; Models, Genetic; Mutation	1986
Proteolytic processing of the Ada protein that repairs DNA O6-methylguanine residues in E. coli. Mutation research, 1987, Volume: 183, Issue:2 Topics: Bacterial Proteins; DNA Repair; Escherichia coli; Escherichia coli Proteins; Guanine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Peptide Hydrolases; Protein Processing, Post-Translational; Transcription Factors	1987
MNNG-induced partial phenotypic reversion of Mer- cells. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: Alkylating Agents; DNA Repair; Drug Resistance; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Phenotype	1987
Exogenous O6-methylguanine inhibits adduct removal and sensitizes human cells to killing by the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research, 1987, Volume: 184, Issue:3 Topics: Cell Survival; Cells, Cultured; DNA Damage; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase	1987
Cell cycle-dependent modulation of O6-methylguanine-DNA methyltransferase in C3H/10T1/2 cells. Carcinogenesis, 1986, Volume: 7, Issue:5 Topics: Animals; Cell Cycle; Cells, Cultured; DNA Repair; Embryo, Mammalian; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase	1986
Site-specific mutagenesis in vivo by single methylated or deaminated purine bases. Mutation research, 1986, Volume: 162, Issue:2 Topics: Base Sequence; Coliphages; DNA Repair; DNA Replication; DNA, Viral; Guanine; Hypoxanthine; Hypoxanthines; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase	1986
Transfer of the E. coli O6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research, 1986, Volume: 166, Issue:2 Topics: Cell Survival; Cloning, Molecular; DNA Repair; Gene Expression Regulation; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Sister Chromatid Exchange; Transfection	1986
Adaptive response to alkylating agents in mammalian cells. IARC scientific publications, 1986, Issue:70 Topics: Adaptation, Physiological; Alkylating Agents; Animals; Cell Survival; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats	1986
DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells. Carcinogenesis, 1987, Volume: 8, Issue:2 Topics: Adenine; Alkylating Agents; Alkylation; Cell Survival; DNA Repair; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Purines; Sister Chromatid Exchange	1987
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:2 Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy	1985
Bacillus subtilis mutants deficient in the adaptive response to simple alkylating agents. Journal of bacteriology, 1985, Volume: 161, Issue:3 Topics: Alkylating Agents; Bacillus subtilis; DNA Repair; Guanine; Methylnitronitrosoguanidine; Mutation	1985
The cytotoxic and mutagenic effects of alkylating agents on human lymphoid cells are caused by different DNA lesions. Carcinogenesis, 1985, Volume: 6, Issue:5 Topics: Alkylating Agents; Alkylation; Cell Line; Cell Survival; DNA; Guanine; Humans; Lymphocytes; Methylnitronitrosoguanidine; Methyltransferases; Mutagens; O(6)-Methylguanine-DNA Methyltransferase	1985
Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents. Biochemical and biophysical research communications, 1985, Oct-15, Volume: 132, Issue:1 Topics: Cell Division; DNA Repair; Guanine; HeLa Cells; Humans; Lomustine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Time Factors	1985
Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis, 1985, Volume: 6, Issue:12 Topics: Cell Line; Fibroblasts; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Skin	1985
Enzymatic removal of mutagenic and lethal lesions from alkylated DNA. Progress in clinical and biological research, 1983, Volume: 132B Topics: Alkylation; Cell Line; DNA; DNA Repair; Escherichia coli; Guanine; Humans; Methylnitronitrosoguanidine; Mutation; S-Adenosylmethionine	1983
Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine. Journal of bacteriology, 1983, Volume: 153, Issue:2 Topics: Adaptation, Physiological; Bacillus subtilis; Drug Resistance, Microbial; Enzyme Induction; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase	1983
[Biochemical study of the position specificity of rat gastrointestinal cancer induced by MNNG]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1984, Volume: 81, Issue:2 Topics: Administration, Oral; Animals; Duodenal Neoplasms; Guanine; Jejunal Neoplasms; Methylnitronitrosoguanidine; Rats; Rats, Inbred Strains; Stomach Neoplasms	1984
Comparison of repair of O6-methylguanine produced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse and human cells. Carcinogenesis, 1984, Volume: 5, Issue:5 Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; DNA Repair; Embryo, Mammalian; Female; Guanine; Humans; Kinetics; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Neoplasms; Neoplasms, Experimental; Species Specificity	1984
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains. Carcinogenesis, 1983, Volume: 4, Issue:2 Topics: DNA Repair; DNA, Neoplasm; Female; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Phenotype	1983
O6-Methylguanine removal by competent and incompetent human lymphoblastoid lines from the same male individual. Cancer research, 1983, Volume: 43, Issue:7 Topics: Adenine; Cell Division; Cell Line; Chromosome Aberrations; Guanine; Humans; Karyotyping; Lymphocyte Activation; Lymphocytes; Male; Methylnitronitrosoguanidine	1983
Adaptive resynthesis of O6-methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair. Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:17 Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Repair; Female; Guanine; Humans; Kinetics; Methylation; Methylnitronitrosoguanidine; Ovary; Protein Binding	1982
Changes in O6-methylguanine disappearance from rat liver DNA during chronic dimethylnitrosamine administration. A possible similarity between the system removing O6-methylguanine from DNA in rat liver and in Escherichia coli adapted to N-methyl-N'-nitro-N Chemico-biological interactions, 1980, Volume: 31, Issue:2 Topics: Animals; Dimethylnitrosamine; DNA; DNA, Bacterial; Enzyme Induction; Escherichia coli; Female; Guanine; Liver; Methylnitronitrosoguanidine; Rats; Time Factors	1980
Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli. Biochemical and biophysical research communications, 1980, Nov-28, Volume: 97, Issue:2 Topics: Deoxyguanosine; Enzyme Induction; Escherichia coli; Guanine; Kinetics; Methylnitronitrosoguanidine; Polydeoxyribonucleotides	1980
Role of the uvrE gene product and of inducible O6-methylguanine removal in the induction of mutations by N-methyl-N'-nitro-N-nitrosoguanidine in Escherichia coli. Journal of molecular biology, 1980, Nov-15, Volume: 143, Issue:4 Topics: Chloramphenicol; DNA Repair; DNA, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Ethyl Methanesulfonate; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Protein Biosynthesis; Ultraviolet Rays	1980
Mismatch correction at O6-methylguanine residues in E. coli DNA. Nature, 1982, Apr-29, Volume: 296, Issue:5860 Topics: DNA Repair; Escherichia coli; Guanine; Methylation; Methylnitronitrosoguanidine	1982
Resistance of Salmonella typhimurium TA 1535 to O6-guanine methylation and mutagenesis induced by low doses of N-methyl-N'-nitro-N-nitrosoguanidine: an apparent constitutive repair activity. Carcinogenesis, 1982, Volume: 3, Issue:3 Topics: Chromatography, High Pressure Liquid; DNA; DNA Repair; Dose-Response Relationship, Drug; Guanine; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutation; Salmonella typhimurium; Time Factors	1982
Excision of O6-methylguanine from DNA by human fibroblasts determined by a sensitive competition method. Carcinogenesis, 1982, Volume: 3, Issue:8 Topics: DNA; Fibroblasts; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases	1982
Adaptive increase of O6-methylguanine-acceptor protein in HeLa cells following N-methyl-N'-nitro-N-nitrosoguanidine treatment. Nucleic acids research, 1982, Aug-11, Volume: 10, Issue:15 Topics: Binding Sites; Guanine; HeLa Cells; Humans; Kinetics; Methylnitronitrosoguanidine; Protein Binding	1982
Repair of O6-methyl-guanine residues in DNA takes place by a similar mechanism in extracts from HeLa cells, human liver, and rat liver. Journal of cellular biochemistry, 1982, Volume: 20, Issue:4 Topics: Animals; DNA; DNA Glycosylases; DNA Repair; Guanine; HeLa Cells; Humans; Liver; Methylation; Methylnitronitrosoguanidine; Methyltransferases; Molecular Weight; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Proteins; Rats	1982
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents. Cancer research, 1981, Volume: 41, Issue:12 Pt 1 Topics: Adolescent; Adult; Alkylating Agents; Ataxia Telangiectasia; Cell Division; Cells, Cultured; Child; DNA; DNA Repair; Female; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea	1981
Limited capacity for the removal of O6-methylguanine and its regeneration in a human lymphoma line. Carcinogenesis, 1981, Volume: 2, Issue:12 Topics: Burkitt Lymphoma; Carcinogens; Cell Line; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine	1981
Decreased excision of O6-methylguanine and N7-methylguanine during the S phase in 10T1/2 cells. Biochemical and biophysical research communications, 1980, Feb-12, Volume: 92, Issue:3 Topics: Animals; Cell Cycle; Cell Division; Cell Line; DNA; Guanine; Interphase; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H	1980
Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treated human fibroblasts. Nature, 1981, Feb-26, Volume: 289, Issue:5800 Topics: Ataxia Telangiectasia; Cells, Cultured; DNA Repair; Dose-Response Relationship, Drug; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Mutation; Xeroderma Pigmentosum	1981
On the quantitative relationship between O6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer- human tumor cell line. Mutation research, 1994, Volume: 314, Issue:2 Topics: Base Sequence; Cell Death; DNA; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Mutagens; Mutation; Nucleic Acid Heteroduplexes; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange; Thioguanine; Tumor Cells, Cultured	1994
Mouse methyltransferase for repair of O6-methylguanine and O4-methylthymine in DNA. Carcinogenesis, 1995, Volume: 16, Issue:7 Topics: 3T3 Cells; Animals; Base Sequence; DNA Repair; DNA, Complementary; Guanine; HeLa Cells; Humans; Immunoblotting; Intracellular Fluid; Methylnitronitrosoguanidine; Methyltransferases; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity; Thymine	1995
DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells. Carcinogenesis, 1995, Volume: 16, Issue:8 Topics: Cells, Cultured; DNA Repair; Drug Tolerance; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae	1995
A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells. Mutation research, 1995, Volume: 346, Issue:4 Topics: Alkylating Agents; B-Lymphocytes; Cell Line; Chromosome Aberrations; Dimethylnitrosamine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Erythroid Precursor Cells; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea	1995
Construction and characterization of mutants of Salmonella typhimurium deficient in DNA repair of O6-methylguanine. Journal of bacteriology, 1995, Volume: 177, Issue:6 Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Repair; Dose-Response Relationship, Drug; Escherichia coli Proteins; Genes, Bacterial; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Restriction Mapping; Salmonella typhimurium; Sequence Analysis, DNA; Sequence Deletion; Transcription Factors	1995
Immunocytochemical evidence for a nuclear and a cytoplasmic O6-methylguanine repair mechanism in cultured rat hepatocytes. Journal of toxicology and environmental health, 1994, Volume: 43, Issue:4 Topics: Animals; Antibodies, Anti-Idiotypic; Bacterial Proteins; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA Adducts; DNA Repair; Gold Colloid; Guanine; Immunohistochemistry; Liver; Methylnitronitrosoguanidine; N-Methylaspartate; Rats; Rats, Sprague-Dawley	1994
A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents. Carcinogenesis, 1993, Volume: 14, Issue:8 Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Death; Cell Division; CHO Cells; Cricetinae; DNA Damage; DNA Repair; Drug Hypersensitivity; Drug Resistance; Guanine; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Rats; Tumor Cells, Cultured	1993
Mutagenicity and mutational spectrum of N-methyl-N'-nitro-N-nitrosoguanidine in the hprt gene in G1-S and late S phase of diploid human fibroblasts. Cancer research, 1993, Jun-15, Volume: 53, Issue:12 Topics: Amino Acid Sequence; Aphidicolin; Base Sequence; Cell Cycle; Diploidy; DNA; DNA Replication; Fibroblasts; G1 Phase; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; S Phase; Sequence Analysis, DNA; Time Factors	1993
O6-methylguanine induces intrachromosomal homologous recombination in human cells. Carcinogenesis, 1996, Volume: 17, Issue:10 Topics: Cells, Cultured; Cinnamates; DNA Adducts; Gene Conversion; Guanine; Humans; Hygromycin B; Methylnitronitrosoguanidine; Recombination, Genetic; Thymidine Kinase	1996
Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal Oncogene, 1996, Nov-07, Volume: 13, Issue:9 Topics: Alkylating Agents; Animals; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glycoproteins; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Recombination, Genetic; RNA, Messenger; Transcription Factor AP-1; Transfection; Ultraviolet Rays	1996
Effect of UVM induction on mutation fixation at non-pairing and mispairing DNA lesions. Molecular microbiology, 1996, Volume: 22, Issue:4 Topics: Adenine; Bacteriophage M13; Cytosine; DNA, Single-Stranded; DNA, Viral; Escherichia coli; Guanine; Methylnitronitrosoguanidine; Mutagenesis; Mutagens; Transfection; Ultraviolet Rays	1996
Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents. Mutation research, 1997, Feb-03, Volume: 373, Issue:2 Topics: Alkylating Agents; Animals; Cell Division; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Enzyme Inhibitors; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Thioguanine	1997
Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models. Mutation research, 1997, Nov-28, Volume: 381, Issue:2 Topics: Animals; Apoptosis; Cell Death; CHO Cells; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; DNA Adducts; DNA Methylation; DNA Repair; DNA Replication; Drug Resistance; Guanine; Methylnitronitrosoguanidine; Models, Genetic; Mutagenicity Tests; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange	1997
Critical steps in alkylation-induced aberration formation. Mutation research, 1998, Aug-03, Volume: 404, Issue:1-2 Topics: Alkylating Agents; Animals; Cell Cycle; Chromosome Aberrations; DNA Damage; DNA Repair; DNA Replication; Fibroblasts; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Nucleic Acid Synthesis Inhibitors; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Sister Chromatid Exchange	1998
Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis, 1999, Volume: 20, Issue:1 Topics: Amino Acid Substitution; Codon; DNA Damage; DNA Repair; Escherichia coli; Guanine; Humans; Methylnitronitrosoguanidine; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Recombinant Fusion Proteins; Thymidine	1999
Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA. Nucleic acids research, 1999, Apr-15, Volume: 27, Issue:8 Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Repair; DNA, Complementary; Drosophila melanogaster; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thymine; Transcription Factors	1999
Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15. Carcinogenesis, 1999, Volume: 20, Issue:3 Topics: Base Pair Mismatch; Base Sequence; Colonic Neoplasms; DNA Primers; DNA Repair; DNA-Binding Proteins; DNA, Complementary; G2 Phase; Guanine; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Microsatellite Repeats; Mutation; Phenotype; Transfection; Tumor Cells, Cultured	1999
Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase. Carcinogenesis, 2000, Volume: 21, Issue:7 Topics: DNA Damage; DNA Repair; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Lac Operon; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Point Mutation; Substrate Specificity; Thymine	2000
Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents. The Journal of biological chemistry, 2000, Nov-17, Volume: 275, Issue:46 Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Alkylating Agents; Base Pair Mismatch; Carrier Proteins; Cell Line; Cell Nucleus; Cytoplasm; DNA; DNA Damage; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Gene Expression Regulation; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Proto-Oncogene Proteins; RNA Stability; RNA, Messenger	2000
Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts. Carcinogenesis, 2000, Volume: 21, Issue:9 Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Pair Mismatch; Carcinogens; Cell Line; DNA; DNA Adducts; DNA Damage; DNA Repair; Fibroblasts; Guanine; Humans; Methylnitronitrosoguanidine; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombination, Genetic	2000
Replication past O(6)-methylguanine by yeast and human DNA polymerase eta. Molecular and cellular biology, 2000, Volume: 20, Issue:21 Topics: Alkylating Agents; Base Sequence; Cytosine; DNA Polymerase III; DNA Polymerase iota; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Fungal Proteins; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutation; Thymidine	2000
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. Cancer research, 2000, Oct-15, Volume: 60, Issue:20 Topics: Animals; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; CHO Cells; Cricetinae; Cytochrome c Group; DNA Damage; Enzyme Activation; Fas Ligand Protein; fas Receptor; Guanine; Membrane Glycoproteins; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Phosphorylation; Protease Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2	2000
Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine. Cancer research, 2001, Jan-01, Volume: 61, Issue:1 Topics: Alkylating Agents; Animals; CHO Cells; Cricetinae; DNA; DNA Topoisomerases, Type I; Guanine; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Transfection	2001
The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells. Cancer research, 2003, Sep-15, Volume: 63, Issue:18 Topics: Cell Survival; Cells, Cultured; DNA Mutational Analysis; Exons; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Methylnitronitrosoguanidine; Mutation; O(6)-Methylguanine-DNA Methyltransferase; T-Lymphocytes	2003
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1. Oncogene, 2004, Jan-15, Volume: 23, Issue:2 Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Division; Dacarbazine; DNA Damage; DNA Replication; fas Receptor; Gamma Rays; Gene Expression Regulation; Guanine; Humans; Lymphocytes; Methylnitronitrosoguanidine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Temozolomide; Tumor Suppressor Protein p53	2004
Quantitation of the adaptive response to alkylating agents. Nature, 1979, Jul-05, Volume: 280, Issue:5717 Topics: Adaptation, Physiological; Alkylation; Chloramphenicol; DNA Damage; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Guanine; Methylnitronitrosoguanidine; Mutagens; Temperature	1979
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA. Nature, 1979, Jul-05, Volume: 280, Issue:5717 Topics: Adaptation, Physiological; Alkylation; DNA Damage; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Guanine; Methylnitronitrosoguanidine; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors	1979
Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli. Nucleic acids research, 2005, Volume: 33, Issue:12 Topics: Alkyl and Aryl Transferases; DNA; DNA Glycosylases; Endonucleases; Escherichia coli; Escherichia coli Proteins; Guanine; Methylnitronitrosoguanidine; Mutation; O(6)-Methylguanine-DNA Methyltransferase	2005
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene, 2007, Jan-11, Volume: 26, Issue:2 Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Caspases; Cell Cycle; Cell Proliferation; Dacarbazine; DNA Breaks, Double-Stranded; DNA Damage; Fas Ligand Protein; Fas-Associated Death Domain Protein; Flow Cytometry; Glioma; Guanine; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53	2007
Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair. Cell death and differentiation, 2007, Volume: 14, Issue:8 Topics: Animals; Apoptosis; Base Sequence; Cell Differentiation; DNA Adducts; DNA Damage; DNA Methylation; DNA Mismatch Repair; DNA-Binding Proteins; DNA, Complementary; E2F1 Transcription Factor; Embryonic Stem Cells; Fibroblasts; Guanine; Methylnitronitrosoguanidine; Mice; Models, Biological; MutS Homolog 2 Protein; O(6)-Methylguanine-DNA Methyltransferase; Pluripotent Stem Cells; Swiss 3T3 Cells	2007
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. Cancer research, 2008, Dec-01, Volume: 68, Issue:23 Topics: Alkylating Agents; Amino Acid Sequence; Animals; BRCA2 Protein; DNA Repair; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Mice; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase	2008
Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles. Cell cycle (Georgetown, Tex.), 2010, Jan-01, Volume: 9, Issue:1 Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; CHO Cells; Cricetinae; Cricetulus; DNA Breaks, Double-Stranded; DNA Replication; Flow Cytometry; Fluoresceins; Guanine; Methylnitronitrosoguanidine; Microscopy, Fluorescence; O(6)-Methylguanine-DNA Methyltransferase; Succinimides	2010
RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine. DNA repair, 2010, Apr-04, Volume: 9, Issue:4 Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; DNA Damage; DNA Repair; DNA-Binding Proteins; Embryo, Mammalian; Fibroblasts; G2 Phase; Guanine; Methylnitronitrosoguanidine; Mice; MutL Protein Homolog 1; Nuclear Proteins; Rad51 Recombinase	2010
Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide. Molecular pharmacology, 2010, Volume: 78, Issue:5 Topics: Antineoplastic Agents, Alkylating; Apoptosis; Caspase 7; Cell Cycle Proteins; Cell Line, Transformed; Cell Line, Tumor; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Fibroblasts; Guanine; Homozygote; Humans; Melanoma; Methylnitronitrosoguanidine; Mutagens; Mutation; Necrosis; Nijmegen Breakage Syndrome; Nuclear Proteins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Temozolomide; Uveal Neoplasms	2010
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. The Journal of biological chemistry, 2010, Dec-24, Volume: 285, Issue:52 Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mechanistic Target of Rapamycin Complex 1; Methylnitronitrosoguanidine; Multiprotein Complexes; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2010
Role of alkyltransferase-like (ATL) protein in repair of methylated DNA lesions in Thermus thermophilus. Mutagenesis, 2011, Volume: 26, Issue:2 Topics: Alkyl and Aryl Transferases; DNA Damage; DNA Methylation; DNA Repair; Genetic Vectors; Guanine; Methylnitronitrosoguanidine; Mutagens; Mutation; Restriction Mapping; Thermus thermophilus	2011
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Molecular cell, 2012, Jul-13, Volume: 47, Issue:1 Topics: Alkyl and Aryl Transferases; Blotting, Western; Crystallography, X-Ray; DNA Damage; DNA Repair; DNA, Fungal; Flow Cytometry; G1 Phase; Genome, Fungal; Guanine; Methylnitronitrosoguanidine; Models, Molecular; Mutation; Nitrosourea Compounds; Nucleic Acid Conformation; Protein Binding; Protein Structure, Tertiary; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription, Genetic	2012
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide. Molecular cancer therapeutics, 2013, Volume: 12, Issue:11 Topics: Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Melanoma; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinases; Signal Transduction; Temozolomide; Tumor Suppressor Proteins	2013
The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity. DNA repair, 2015, Volume: 28 Topics: Alkyl and Aryl Transferases; Alkylating Agents; Animals; Apoptosis; CHO Cells; Cricetinae; Cricetulus; DNA; DNA Adducts; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Escherichia coli Proteins; Guanine; Humans; Methylnitronitrosoguanidine; Transgenes; Tumor Suppressor Proteins	2015