o-(6)-methylguanine has been researched along with guanine in 727 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 279 (38.38) | 18.7374 |
| 1990's | 243 (33.43) | 18.2507 |
| 2000's | 99 (13.62) | 29.6817 |
| 2010's | 87 (11.97) | 24.3611 |
| 2020's | 19 (2.61) | 2.80 |
| Authors | Studies |
|---|---|
| Abbott, PJ; Saffhill, R | 1 |
| Brésil, H; Margison, GP; Montesano, R | 1 |
| Cox, R; Irving, CC | 1 |
| Roberts, JJ; Shackleton, J; Warren, W | 1 |
| Briscoe, WT; Spizizen, J; Tan, EM | 1 |
| Pegg, AE | 4 |
| Hui, G; Pegg, AE | 1 |
| Inoue, H; Ishikawa, H; Kamiya, H; Komatsu, Y; Miura, H; Murata, N; Murata, T; Sasaki, T; Shimizu, M; Suzuki, M | 1 |
| de los Santos, H; Spratt, TE | 1 |
| Armier, J; Gentil, A; Kyrtopoulos, SA; Margot, A; Pletsa, V; Sarasin, A | 1 |
| Bigner, DD; Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Pegg, AE; Rich, J; Schold, SC | 1 |
| Basic-Zaninovic, T; Bignami, M; Dogliotti, E; Palombo, F | 1 |
| Bonfanti, M; Catapano, CV; Citti, L; D'Incalci, M; Taverna, P | 1 |
| Aquilina, G; Bignami, M; Biondo, R; Dogliotti, E; Meuth, M | 1 |
| Beattie, C; Guzman, RC; Hamdan, MA; Mascharack, P; Nandi, S; Yang, J | 1 |
| Den Engelse, L; Scherer, E; Van Benthem, J; Vermeulen, E; Wild, CP; Winterwerp, HH | 1 |
| Castonguay, A; Gerson, SL; Liu, L | 1 |
| Bevill, RF; Fong, LY; Magee, PN; Thurmon, JC | 1 |
| Li, BF; Tan, NW; Wong, CW | 1 |
| Day, RS | 2 |
| Klein, S; Oesch, F | 2 |
| Byers, TL; Pegg, AE | 1 |
| Cooper, DP; Griffin, KA; Povey, AC | 1 |
| Arce, C; Berger, NA; Gerson, SL; Petzold, SJ; Willson, JK | 1 |
| Archer, MC; Chaulk, EJ; Lu, SJ | 1 |
| Adrian, TE; Corra, S; Kazakoff, K; Lawson, TA; Pour, PM | 1 |
| Amin, SG; Chung, FL; Han, C; Ho, CT; Xu, Y | 1 |
| Bignami, M; Karran, P | 2 |
| Boussiotis, VA; Kyrtopoulos, SA; Pangalis, GA; Souliotis, VL | 1 |
| Archer, MC; Lu, SJ; Milligan, JR | 1 |
| Couri, D; Dutta-Choudhury, TA; Stephens, RE | 1 |
| Lawson, T | 1 |
| Dosanjh, MK; Galeros, G; Goodman, MF; Singer, B | 1 |
| Dolan, ME; Dumenco, LL; Gerson, SL; Moschel, RC; Pegg, AE | 1 |
| Chen, JS; Guo, ZL; Liu, ZQ; Xiao, Y; Zhu, JQ | 1 |
| Cao, EH; Fan, XJ; Liu, YY; Xin, SM; Yu, HT; Yuan, XH | 1 |
| Erickson, LC | 1 |
| Ahnström, G; Eizirik, DL; Sandler, S; Welsh, M | 1 |
| Bignami, M; Karran, P; Lane, DP | 1 |
| Butler, WH; Fan, CY; O'Connor, PJ | 2 |
| Chung, FL; Eklind, KI; Hecht, SS; Morse, MA | 1 |
| Ambatzi, P; Bousiotou, V; Davaris, G; Haritopoulos, G; Kyrtopoulos, SA; Pangalis, G; Souliotis, VL | 1 |
| Loechler, EL | 1 |
| Bolt, HM; Foest, U; Gansewendt, B; Hallier, E; Peter, H; Xu, D | 1 |
| Keefer, LK; Kleihues, P; Nims, RW; Reist, EJ; Schmerold, I; von Hofe, E | 1 |
| Hecht, SS; Peterson, LA | 1 |
| Bochert, G; Neubert, D; Platzek, T; Rahm, U | 1 |
| Georgiadis, P; Smith, CA; Swann, PF | 1 |
| Den Engelse, L; Scherer, E; Van Benthem, J; Vermeulen, E; Wild, CP | 1 |
| Kamiya, H; Miura, K; Nishimura, S; Ohtomo, N; Ohtsuka, E | 1 |
| Bonfanti, M; Broggini, M; D'Incalci, M; Prontera, C | 1 |
| Elksne, SJ; Gorbacheva, LB; Kukushkina, GV; Miniker, TD; Preobrazhenskaya, MN | 1 |
| Dunn, WC; Horesovsky, GJ; Mitra, S; Preston, RJ; Tano, K | 1 |
| Rossi, SC; Topal, MD | 1 |
| Dosanjh, MK; Essigmann, JM; Samson, L; Sassanfar, M | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR | 2 |
| Hepburn, PA; Margison, GP; Tisdale, MJ | 1 |
| Essigmann, JM; Singer, B | 1 |
| Arce, C; Dumenco, LL; Gerson, SL; Norton, K; Wagner, T; Yun, J | 1 |
| Hutchinson, F; Romac, S; Sockett, H | 1 |
| Dosanjh, MK; Essigmann, JM; Singer, B | 1 |
| Archer, MC; Chin, W; Cooper, DP; Dai, WD; Lee, V; O'Connor, PJ | 1 |
| Carne, AF; Gardner, EJ; Lawley, PD; Major, GN | 1 |
| Basu, AK; Benasutti, M; Essigmann, JM; Green, CL; Loechler, EL | 1 |
| Abbondandolo, A; Bonatti, S; Cercignani, G; Rocco, M | 1 |
| Topal, MD; Voigt, JM | 3 |
| Dolan, ME; Moschel, RC; Pegg, AE | 1 |
| Bignami, M; Lane, DP | 1 |
| Kawazoe, Y; Sekiguchi, M; Takahashi, K | 1 |
| Brent, TP; Gonzaga, PE; Harris, L; Margison, GP | 1 |
| Arita, I; Fujimori, A; Takebe, H; Tatsumi, K | 1 |
| Zhang, PC | 1 |
| Brown, T; Leonard, GA; Thomson, J; Watson, WP | 1 |
| Li, BF; Tan, NW | 1 |
| Berman, HM; Ginell, SL; Jones, RA; Kuzmich, S | 1 |
| D'Ambrosio, SM; Gibson-D'Ambrosio, R; Samuel, M; Wani, AA; Wani, G | 1 |
| Nehls, P; Rajewsky, MF | 1 |
| Ampatzi, P; Davaris, P; Golematis, B; Haritopoulos, N; Kyrtopoulos, SA | 1 |
| Boussiotis, VA; Kaila, S; Kyrtopoulos, SA; Pangalis, GA; Souliotis, VL | 1 |
| Ebisuzaki, K; Kalamegham, R | 1 |
| Smith, CA; Swann, PF; Xu, YZ | 1 |
| Anderson, MW; Belinsky, SA; Foley, JF; Maronpot, RR; White, CM | 1 |
| Choi, CI; Hecht, SS; Jordan, KG; Trushin, N | 1 |
| Hayakawa, H; Koike, G; Sekiguchi, M | 1 |
| Fushimi, S; Ikenaga, M; Ishizaki, K; Isowa, G; Kowada, M; Mineura, K | 1 |
| Aquilina, G; Bignami, M; Di Muccio, A; Dogliotti, E; Giammarioli, AM; Zijno, A | 1 |
| Lawson, TA | 1 |
| Samson, L; Sassanfar, M | 1 |
| Simons, JW; Zdzienicka, MZ | 1 |
| Laval, F; Lefebvre, P | 2 |
| Schmerold, I; Spath, A | 1 |
| Dolan, ME; Morimoto, K; Pegg, AE | 2 |
| Bromley, M; Fida, S; O'Connor, PJ; Saffhill, R | 1 |
| Abbondandolo, A; Bonatti, S; Cercignani, G; De Ferrari, M; Ipata, PL; Rocco, M; Tozzi, MG; Viaggi, S | 1 |
| Barnes, DM; Erickson, LC; Fisher, RI; Futscher, BW; Micetich, KC | 1 |
| Sancar, A; Topal, MD; Van Houten, B; Voigt, JM | 1 |
| Doerjer, G; Krause, T; Lehnert, G; Nowak, D; Rüdiger, HW; Schwartz, U; Serrand, E; Stief, M | 1 |
| Archer, MC; Catz-Biro, L; Hirani-Hojatti, S; Milligan, JR | 1 |
| Dolan, ME; English, HF; Larkin, GL; Pegg, AE | 1 |
| D'Ambrosio, SM; Gibson-D'Ambrosio, R; Lowder, E; Samuel, M; Wani, AA; Wani, G | 1 |
| Greene, PS; Mandel, HG; Richardson, DC; Straw, JA | 1 |
| Martel-Planche, G; Mironov, NM; Montesano, R; Swann, PF; Wild, CP | 1 |
| Pratviel, G; Sartorelli, AC; Shyam, K | 1 |
| Conrad, M; Rossi, SC; Topal, MD; Voigt, JM | 1 |
| Den Engelse, L; Scherer, E; Van Den Berg, T; Vermeulen, E; Winterwerp, HH | 1 |
| Hart, RW; Lipman, JM; Turturro, A | 1 |
| Deininger, C; Eder, E; Wiedenmann, M | 1 |
| Basu, AK; Essigmann, JM; Loechler, EL | 1 |
| Hall, J; Karran, P | 1 |
| Chaudhuri, I; Couto, LB; Demple, B; Donahue, BA; Essigmann, JM | 1 |
| Goad, DL; Rebeck, GW; Samson, L; Smith, CM | 1 |
| Chavez, F; Dosanjh, MK; Essigmann, JM; Goodman, MF; Singer, B | 1 |
| Kyrtopoulos, SA; Souliotis, VL | 1 |
| Cawkwell, L; Georgiadis, P; Margison, GP; Patel, D; Potter, PM; Swann, PF; Wilkinson, MC | 1 |
| Gerson, SL; Trey, JE | 2 |
| Amin, SG; Chung, FL; Hecht, SS; Morse, MA | 1 |
| Dexter, EU; Donovan, C; Gerson, SL; Yamashita, TS | 1 |
| Katz, A; Waldstein, E; Yawetz, A | 1 |
| Murphy, SE | 1 |
| Clyde, C; Dolan, ME; Erickson, LC; Hora, NK; Norbeck, L; Pegg, AE | 1 |
| Gaffney, BL; Jones, RA | 1 |
| Klaude, M; von der Decken, A; Wernerman, J | 1 |
| Kalnik, MW; Li, BF; Patel, DJ; Swann, PF | 1 |
| Basu, AK; Connors, TD; Dogliotti, E; Ellison, KS; Essigmann, JM | 1 |
| Barrows, LR; Borchers, AH; Paxton, MB | 1 |
| Dolan, ME; Erickson, LC; Hora, NK; Pegg, AE | 1 |
| Bradbrook, C; Charlesworth, JD; Chu, YH; Cooper, DP; Margison, GP; O'Connor, PJ; Styles, J | 1 |
| Fushimi, S; Ishino, Y; Kowada, M; Mineura, K; Sasajima, H; Sasaki, J | 1 |
| Kleihues, P; Meer, L; Schold, SC | 1 |
| Bhanot, OS; Ray, A | 1 |
| Chambers, RW; Hirani-Hojatti, S; Sledziewska-Gojska, E | 1 |
| Lindahl, T; McCarthy, TV | 1 |
| Borowy-Borowski, H; Chambers, RW; Hirani-Hojatti, S; Sledziewska-Gojska, E | 1 |
| Kilpatrick, MW; Lindahl, T; McCarthy, TV; Sedgwick, B; Teo, I | 1 |
| Bresnick, E; Ding, R; Eastman, A; Ghosh, K | 1 |
| Rajewsky, MF; Samson, L; Thomale, J | 1 |
| Morohoshi, F; Munakata, N | 2 |
| Aulmann, W; Doerjer, G; Oesch, F; Platt, KL | 1 |
| Abbondandolo, A; Bignami, M; Calcagnile, A; Dogliotti, E; Frosina, G; Terlizzese, M; Zijno, A | 1 |
| Horie, Y; Huh, NH; Kuroki, T; Rajewsky, MF; Satoh, MS; Thomale, J | 1 |
| Gerson, SL; Miller, K; Trey, JE | 1 |
| Bromley, M; Fan, CY; Fida, S; O'Connor, PJ; Saffhill, R | 1 |
| Anderson, MW; Belinsky, SA; Dolan, ME; Maronpot, RR; Pegg, AE; White, CM | 1 |
| Dolan, ME; Oplinger, M; Pegg, AE | 1 |
| Barch, DH; Fox, CC | 2 |
| Brdar, B; Matulić, M | 1 |
| Badawi, AF; Hall, CN; Saffhill, R | 1 |
| Citti, L; Coccia, P; Diomede, L; Mariani, L; Romano, M; Salmona, M | 1 |
| Poltev, VI; Steinberg, SV | 1 |
| Babich, MA; Day, RS; Scudiero, DA; Yarosh, DB | 1 |
| Graves, RJ; Li, BF; Swann, PF | 1 |
| den Engelse, L; Jenner, AA; Scherer, E | 1 |
| Lambert, CE; Shank, RC | 1 |
| Dolan, ME; Pegg, AE; Scicchitano, D | 1 |
| Fiala, ES; Hamilton, SR; Sohn, OS | 1 |
| Denman, AM; Harris, G; Hill, ID; Hylton, W; Lawley, PD; Topper, R | 1 |
| Anisimov, V; Likhachev, A; Petrov, A; Zhukovskaya, N | 1 |
| Colaço, CB; Harris, G; Lawley, PD; Lydyard, PM; Roitt, IM | 1 |
| Anderson, MW; Darden, TA; Deerfield, DW; Hoel, DG; Pedersen, LG | 1 |
| Hall, J; Karran, P; Kataoka, H; Stephenson, C | 1 |
| Lipman, JM; Setlow, RB; Sokoloff, L | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; White, CM | 1 |
| Dixit, R; Gold, B | 1 |
| Tisdale, MJ | 1 |
| Shaw, BR; Williams, LD | 1 |
| Shank, RC | 2 |
| Boyle, JM; Durrant, LG; Margison, GP; Saffhill, R; Wild, CP | 1 |
| Schmerold, I; Wiestler, OD | 1 |
| Conrad, M; Eadie, JS; Topal, MD | 1 |
| Demple, B | 1 |
| Chui, SX; Feng, L; Lu, SH; Luo, FJ; Montesano, R; Rajewsky, MF; Saffhill, R; Umbenhauer, D; Zhang, MS | 1 |
| Essigmann, JM; Green, CL; Loechler, EL | 3 |
| Brennand, J; Margison, GP; Ockey, CH; White, GR | 1 |
| Benjamin, E; Gerson, SL; Miller, K; Trey, JE | 1 |
| Teo, IA | 1 |
| Murray, V | 1 |
| Anderson, MW; Belinsky, SA | 1 |
| Boucheron, J; Deal, F; Richardson, FC; Swenberg, JA; Tyeryar, L | 1 |
| Avitts, TA; Everson, RB; Randerath, E; Randerath, K; Schut, HA | 1 |
| Dempke, W; Nehls, P; Osieka, R; Schmidt, CG; Soll, D; Wandl, U | 1 |
| Cleary, CM; Friedman, S; Parsa, I | 1 |
| Goth-Goldstein, R | 1 |
| Day, RS; Yagi, T | 1 |
| Babich, MA; Day, RS | 1 |
| Adams, JD; Czech, A; LaVoie, EJ; Prokopczyk, G; Rigotty, J; Rivenson, A | 1 |
| Beattie, CW; Braun, RJ; Pezzuto, JM; Ratko, TA | 1 |
| Dolan, ME; Morimoto, K; Pegg, AE; Scicchitano, D | 2 |
| Carmella, SG; Chung, FL; Foiles, PG; Hecht, SS; Lin, D; Rubin, JM; Trushin, N | 1 |
| Anderson, MW; Belinsky, SA; Swenberg, JA | 1 |
| Kalnik, M; Li, BF; Patel, DJ; Swann, PF | 1 |
| Keefer, LK; Kleihues, P; Lijinsky, W; Schmerold, I; von Hofe, E | 1 |
| Kyrtopoulos, SA | 3 |
| Lu, SH; Montesano, R; Wild, CP | 1 |
| Berger, NA; Gerson, SL; Miller, K; Trey, JE | 1 |
| Dunn, WC; Foote, RS; Hand, RE; Mitra, S | 1 |
| Aida, T; Berger, MS; Bodell, WJ; Rosenblum, ML | 1 |
| Essigmann, JM; Gaffney, B; Jones, RA; Kuzmich, S; Lasko, DD; Pegg, AE; Scicchitano, D | 1 |
| Craddock, VM; Henderson, AR | 1 |
| Billett, MA; O'Connor, PJ; Ryan, AJ | 1 |
| Hill-Perkins, M; Jones, MD; Karran, P | 1 |
| Fujio, C; Ikenaga, M; Ishizaki, K; Nakabeppu, Y; Sekiguchi, M; Tsujimura, T; Yawata, H | 1 |
| Cao, EH; Carlson, C; Grist, E; Waldstein, E; White, TE; Woodhead, AD | 1 |
| Bürkle, V; Danecki, S; Grotzke, J; Schweinsberg, F; von Karsa, L | 1 |
| Den Engelse, L; Floot, BG; Menkveld, GJ; Tates, AD | 1 |
| Carlson, C; Grist, E; Woodhead, AD | 1 |
| Kleihues, P; von Hofe, E | 1 |
| Laval, F | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Swenberg, JA; White, CM | 1 |
| Linn, S; Samson, L | 1 |
| Devor, D; Kaufman, DG; Kaufmann, WK; Rice, JM; Wenk, ML | 1 |
| Bosan, WS; Gaworski, CL; MacEwen, JD; Newberne, PM; Shank, RC | 1 |
| Mikhaĭlenko, VM; Rubenchik, BL | 1 |
| Edler, L; Eisenbrand, G; Müller, N; Thielmann, HW | 1 |
| Day, RS; DiPaolo, JA; Doniger, J | 1 |
| Karran, P | 1 |
| Cao, EH; Carlson, C; Grist, E; Holehan, AM; Merry, BJ; Woodhead, AD | 1 |
| Brennand, J; Cooper, DP; Margison, GP | 1 |
| Boiteux, S; Costa de Oliveira, R; Laval, J | 1 |
| Margison, GP; O'Connor, PJ; Saffhill, R | 1 |
| Essigmann, JM; Fowler, KW; Green, CL; Loechler, EL | 2 |
| Caldwell, JW; Kollman, PA | 1 |
| Abbondandolo, A; Frosina, G | 1 |
| Carmella, SG; Chung, FL; Hecht, SS; Wang, M | 1 |
| Castonguay, A; Hecht, SS; Rivenson, A; Trushin, N | 1 |
| Anderson, M; Belinsky, SA; Boucheron, JA; Richardson, FC; Swenberg, JA; White, CM | 1 |
| Jun, GJ; Kim, MH; Kim, S; Magee, PN; Paik, WK; Park, GH; Ro, JY | 1 |
| Saffhill, R | 1 |
| Babich, MA; Day, RS; Hurst-Calderone, S; Yarosh, DB | 1 |
| Colaço, CB; Harris, G; Irving, W; Lawley, PD; Lydyard, PM; Phillips, E; Roitt, IM | 1 |
| Gibson, NW; Hartley, J; La France, RJ; Vaughan, K | 1 |
| Becker, RA; Montesano, R | 1 |
| Curren, RD; Grafstrom, RC; Harris, CC; Yang, LL | 1 |
| Archer, MC; Silinskas, KC; Zucker, PF | 1 |
| Karran, P; Williams, SA | 1 |
| Boiteux, S; Laval, F | 1 |
| Day, RS; Scudiero, DA; Yagi, T; Yarosh, DB | 1 |
| Pezzuto, JM; Ratko, TA | 1 |
| Likhachev, A; Montesano, R; Planche-Martel, G; Wild, CP | 1 |
| Corsico, CD; Dolan, ME; Pegg, AE | 1 |
| Sakai, K; Umeda, T; Yamane, Y | 1 |
| Dolan, ME; Domoradzki, J; Maher, VM; McCormick, JJ; Pegg, AE | 1 |
| Bücher, T; Kerler, R; Legner, M; Müller, L; Rabes, HM; Rode, G; Schuster, C | 1 |
| Briscoe, WT; Cotter, LE | 2 |
| Boucheron, JA; Dyroff, MC; Richardson, FC; Swenberg, JA | 1 |
| Lawley, PD; Miller, CT; Shah, SA | 1 |
| Asbery, L; Denman, AM; Harris, G; Hylton, W; Lawley, PD | 1 |
| Margison, GP | 2 |
| Lewis, JG; Swenberg, JA | 1 |
| Lemaître, M; Verly, WG | 1 |
| Columbano, A; Ledda, GM; Rajalakshmi, S; Rao, PM; Sarma, DS | 2 |
| Karran, P; Lindahl, T | 1 |
| Caswell, N; Felder, MR; Fiala, ES; McCoy, GD; Sohn, OS; Weisburger, JH | 1 |
| Foote, RS; Mitra, S; Snow, ET | 2 |
| Dolan, ME; Pegg, AE; Scicchitano, D; Singer, B | 1 |
| Cao, EH; Delihas, NC; Setlow, RB | 1 |
| Foote, RS; Hadden, CT; Mitra, S | 1 |
| Bresil, H; Cooper, DP; Margison, GP; Montesano, R; O'Connor, PJ; Planche-Martel, G; Smith, RA | 1 |
| Lijinsky, W; Pegg, AE | 1 |
| D'Ambrosio, SM; Gibson-D'Ambrosio, RE; Samuel, M; Wani, G | 1 |
| Lindamood, C; Swenberg, JA; Toorchen, D; Topal, MD | 1 |
| Gaffney, BL; Jones, RA; Marky, LA | 1 |
| Craddock, VM | 1 |
| Autrup, H; James, JT | 1 |
| Brent, TP | 1 |
| Ayres, K; Larson, K; Lindgren, V; Sagher, D; Sklar, R; Strauss, B | 1 |
| Brésil, H; Margison, GP; Montesano, R; Pegg, AE; Planche-Martel, G | 2 |
| Aurich, O; Kaina, B | 1 |
| Archer, MC; Labuc, GE; Silinskas, KC; Zucker, PF | 1 |
| Kleihues, P; Kobori, O; Masako, M; Morioka, Y; Wiestler, O | 1 |
| Clatterbuck, BE; Day, RS; Mattern, MR; Meyer, SA; Scudiero, DA; Ziolkowski, CH | 1 |
| Day, RS; Yagi, T; Yarosh, DB | 1 |
| Singer, B | 1 |
| Bonatsos, M; Golematis, B; Kyrtopoulos, SA; Lakiotis, G; Vrotsou, B | 1 |
| Hesse, S; Mezger, M; Wiebel, FJ | 1 |
| Kerler, R; Rabes, HM; Rode, G; Schuster, C; Wilhelm, R | 1 |
| Ivankovic, S; Kleihues, P; Rice, JM; Wiestler, OD | 1 |
| Foote, RS; Mitra, S; Pal, BC | 3 |
| Chu, YH; Craig, AW; O'Connor, PJ | 1 |
| Chu, YH; Margison, GP; Maru, GB; O'Connor, PJ | 1 |
| Foote, RS; Mitra, S; Pegg, AE; Perry, W; Wiest, L | 1 |
| Bamborschke, S; Kleihues, P; Margison, GP; Maru, GB; O'Connor, PJ | 1 |
| Pegg, AE; Wiest, L | 1 |
| Day, RS; Foote, RS; Mitra, S; Yarosh, DB | 1 |
| Becker, Y; Shiloh, Y; Tabor, E | 1 |
| Aurich, O; Heindorff, K; Kaina, B | 1 |
| Sklar, RM; Strauss, BS | 1 |
| Jones, RA; Kuzmich, S; Marky, LA | 1 |
| Asbery, LJ; Chandler, PM; Harris, G; Jones, MG; Lawley, PD | 1 |
| Alekandrov, VA; Anisimov, VN; Bespalov, VG; Korsakov, MV; Likhachev, AJ; Napalkov, NP; Ovsyannikov, AI; Popovich, IG; Tomatis, L | 1 |
| Cao, EH; Cronkite, EP; Miller, ME; Setlow, RB; Waldstein, EA | 1 |
| Cao, EH; Setlow, RB; Waldstein, EA | 3 |
| Bresil, H; Foote, RS; Likhachev, A; Mitra, S; Montesano, R; Pegg, AE; Roberfroid, M; von Bahr, C | 1 |
| Dodson, LA; Foote, RS; Masker, WE; Mitra, S | 1 |
| Mace, R; Swann, PF | 1 |
| Lindahl, T; Olsson, M | 1 |
| Sklar, R; Strauss, B | 1 |
| Brown, PR; Zakaria, M | 1 |
| Karran, P; Marinus, MG | 1 |
| Lindahl, T; Sedgwick, B | 1 |
| Karran, P; Sedgwick, B; Stevens, S | 1 |
| Guttenplan, JB; Milstein, S | 1 |
| Villani, G | 1 |
| Hadjiloucas, E; Kyrtopoulos, SA; Vrotsou, B | 1 |
| Barrows, LR; Magee, PN | 1 |
| Bedell, MA; Billings, KC; Lewis, JG; Swenberg, JA | 1 |
| Kerler, R; Rabes, HM; Rode, G; Wilhelm, R | 1 |
| Lemaître, M; Renard, A; Verly, WG | 1 |
| Craddock, VM; Gash, S; Henderson, AR | 1 |
| Karran, P; Teo, IA | 1 |
| Bedell, MA; Belinsky, SA; Swenberg, JA | 1 |
| Giercksky, KE; Krokan, H; Myrnes, B | 1 |
| Pegg, AE; Scicchitano, D | 1 |
| Kyrtopoulos, SA; Swann, PF | 1 |
| Der, O; Sellinger, OZ | 1 |
| Harbach, PR; Swenberg, JA | 1 |
| Bogden, JM; Bresnick, E; Eastman, A | 1 |
| Herron, DC; Shank, RC | 1 |
| Kyrtopoulos, SA; Vrotsou, B | 1 |
| De Brij, RJ; Den Engelse, L; Philippus, EJ | 1 |
| Bull, AW; Burd, AD; Nigro, ND | 1 |
| Becker, Y; Shiloh, Y | 1 |
| Lawrence, JF; Leduc, R; Ryan, JJ | 1 |
| Bennett, RA; Pegg, AE; Perry, W | 1 |
| Barrows, LR; Becker, RA; Shank, RC | 1 |
| Pegg, AE; Perry, W | 1 |
| Brady, K; Sklar, R; Strauss, B | 1 |
| Craig, AW; Galbraith, AI; Itzhaki, RF; Margison, GP | 1 |
| Grisham, JW; Kaufman, DG; Smith, GJ | 1 |
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| Guo, W; Liang, G; Liu, H; Liu, R; Pan, E; Pu, Y; Sheng, J; Su, Y; Tang, D; Wang, Y; Yin, L; Zhang, J | 1 |
| Armknecht, S; Johnston, T; Reynolds, M; Zhitkovich, A | 1 |
| Kaina, B; Roos, WP | 1 |
| Lawley, PD; Warren, W | 1 |
| Craig, AW; Margison, GP; Ockey, CH; Swindell, JA | 1 |
| Aquilina, G; Dogliotti, E; Fortini, P; Lupari, E; Marcon, F; Ventura, I | 1 |
| Arvai, AS; Butt, A; Latypov, VF; Margison, GP; Marriott, AS; McGown, G; Millington, CL; Povey, AC; Santibanez-Koref, MF; Senthong, P; Tainer, JA; Thorncroft, M; Tubbs, JL; Watson, AJ; Wilkinson, OJ; Williams, DM | 1 |
| Fried, MG; Melikishvili, M | 1 |
| Lauffenburger, DA; Noonan, EM; Samson, LD; Shah, D; Yaffe, MB | 1 |
| Kuhnle, GG; Moore, SA; Pasmans, F; Vanden Bussche, J; Vanhaecke, L | 1 |
| Fujikane, R; Hidaka, M; Sanada, M; Sekiguchi, M | 1 |
| Hidaka, M; Sakagami, R; Sano, S; Sekiguchi, M | 1 |
| Christmann, M; Kaina, B; Knizhnik, AV; Nikolova, T; Quiros, S; Roos, WP; Tomaszowski, KH | 1 |
| Collins, AR; Lima, CF; Pedro, DF; Pereira-Wilson, C; Ramos, AA | 1 |
| Fung, CF; Ho, AS; Kiang, KM; Lam, KF; Leung, GK; Lui, WM; Pu, JK; Sun, S; Wong, TS; Zhang, XQ | 1 |
| Ding, X; Liu, Z; Megaraj, V; Xie, F; Yang, W; Zhou, X | 1 |
| Angelov, T; Guengerich, FP; Stornetta, A; Sturla, SJ | 1 |
| Eich, M; Kaina, B; Nikolova, T; Roos, WP | 1 |
| Chao, MR; Chen, JL; Hu, CW; Lee, H; Li, YJ | 1 |
| Da Pieve, C; Moore, SA; Sahgal, N; Velasco-Garcia, MN | 1 |
| Head, RJ; Hu, Y; Kim, SW; Le Leu, RK; Lockett, TJ; Margison, GP; Nyskohus, LS; Watson, AJ; Young, GP | 1 |
| Barnholtz-Sloan, J; Cohen, ML; Ondracek, A; Ostrom, Q; Sloan, A | 1 |
| Balbo, S; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Chewonarin, T; Summart, R | 1 |
| Koag, MC; Lee, S | 1 |
| Abo, RP; Ahmad, A; Butty, VL; Chaim, IA; Forget, AL; Margulies, CM; Mazzucato, P; McRee, SK; Nagel, ZD; Samson, LD | 1 |
| Kikuchi, Y; Margison, GP; Millington, CL; Takénaka, A; Tsunoda, M; Wilkinson, O; Williams, DM; Zhang, F | 1 |
| De Smet, S; Raes, K; Van Hecke, T; Vanden Bussche, J; Vanhaecke, L; Vossen, E | 1 |
| Balbo, S; Grill, AE; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Peterson, LA; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Fried, MG; Hellman, LM; Koontz, CJ; Melikishvili, M; Spear, TJ | 1 |
| Boby, ML; Gahlon, HL; Sturla, SJ | 1 |
| Blumenthal, DT; Moore, DF; Padula, GD; Rankin, C; Rushing, EJ; Schulman, SB; Sloan, AE; Spence, AM; Stelzer, KJ; Wade, ML | 1 |
| Artola Borán, M; Costanzo, V; Enoiu, M; Jiricny, J; Kallenberger, L; Olivera Harris, M | 1 |
| Aasland, D; Fuchs, RP; Kaina, B; Margison, GP; Modesti, M; Pinder, SI; Tomaszowski, KH; Williams, E | 1 |
| Chen, NZ; Chen, ZJ; Jin, C; Ye, LC; Zheng, CG | 1 |
| Gold, B; Whetstone, RD | 1 |
| Beuning, PJ; Engen, JR; Lu, X; Nevin, P; Zhang, K | 1 |
| Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N | 1 |
| Hu, J; Jiang, J; Ma, F; Zhang, Z | 1 |
| Boldorini, R; Buosi, R; Gaudino, E; Mancuso, G; Mercalli, F; Mezzapelle, R; Miglio, U; Paganotti, A; Rena, O; Veggiani, C | 1 |
| Amin, SG; Belinsky, SA; Collins, LB; Crowell, RE; Desai, D; Gilliland, FD; Jauregui, AR; Juri, DE; Leng, S; Lin, Y; Liu, Y; Picchi, MA; Stidley, CA; Swenberg, JA; Tellez, CS; Thomas, CL; Wathelet, MG; Wu, G; Zhang, X | 1 |
| Decloedt, AI; Geboes, KP; Hemeryck, LY; Vanden Bussche, J; Vanhaecke, L | 1 |
| Bui, Y; Cloughesy, TF; Hong, I; Lai, A; Liau, LM; McBride, WH; Menjivar, JC; Nelson, SF; Stream, A; Tso, CL; Tso, JL; Yamada, K; Yang, S; Yong, WH; Zhang, Y | 1 |
| Arita, H; Fukushima, S; Ichimura, K; Matsushita, Y; Miyakita, Y; Narita, Y; Ohno, M; Shibui, S; Takami, H; Yonezawa, M; Yoshida, A | 1 |
| Chen, J; Gu, S; Li, Y; Liu, B; Wang, C; Wang, W; Xue, Q; Zhang, H | 1 |
| Dahlmann, HA; Nilforoushan, A; Stäuble, CK; Sturla, SJ; Trantakis, IA | 1 |
| Marx, A; Nilforoushan, A; Sturla, SJ; Williams, DM; Wyss, LA | 1 |
| Cormier, M; LeBlanc, VC; Morin, PJ; St-Coeur, PD; Touaibia, M | 1 |
| Dexter, HR; Millington, CL; Räz, MH; Sturla, SJ; van Loon, B; Williams, DM | 1 |
| Clarke, JM; Head, RJ; Lannagan, T; Le Leu, RK; Lockett, T; Mano, MT; Scherer, BL; Winter, JM | 1 |
| Luedtke, NW; Marsoner, T; Schmidt, OP; Triemer, T | 1 |
| Bastek, H; Benda, N; Collins, LB; Damme, K; Dietrich, DR; Ellinger-Ziegelbauer, H; Frötschl, R; Klaus, V; Lutter, D; Stemmer, K; Swenberg, JA | 1 |
| Barooah, P; Bhattacharyya, M; Deka, M; Goswami, B; Husain, SA; Medhi, S; Rehman, AU; Saikia, S; Sarmah, P | 1 |
| Goodfellow, E; Jean-Claude, B; Senhaji Mouhri, Z | 1 |
| Hecht, SS; Leitzman, P; Narayanapillai, SC; O'Sullivan, MG; Puppala, M; Sun, H; Upadhyaya, P; Xing, C | 1 |
| Cosgrove, L; Fay, MF; Head, RJ; Martin, JH; Rundle-Thiele, D; Y C Fung, K | 1 |
| Arpagaus, B; Brambilla, D; Casalini, T; Grandjean, J; Leroux, JC; Luciani, P; Martin, E; Papachristodoulou, A; Roth, P; Signorell, RD; Steiniger, F; Thamm, J; Weller, M; Werner, B; Xiao, J | 1 |
| Duncan Lyngdoh, RH; Premila Devi, S; Salam, T | 1 |
| Kamiya, H; Kuramoto, Y; Suzuki, T | 1 |
| Chumakova, A; Lathia, JD | 1 |
| Burns, JA; Dreij, K; Ezerskyte, M; Malvezzi, S; Margison, GP; Olsson, M; Paredes, JA; Scicchitano, DA | 1 |
| Ahluwalia, MS; Angelov, L; Barnett, GH; Bellamkonda, S; Jia, X; Meola, A; Mohammadi, A; Mohapatra, S; Sharma, M; Vogelbaum, M | 1 |
| Chariyakornkul, A; Chewonarin, T; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R | 1 |
| Belousova, EA; Boldinova, EO; Lavrik, OI; Makarova, AV | 1 |
| Xu, J | 1 |
| Cheng, Y; Li, W; Xu, H; Zhong, S | 1 |
| Balbo, S; Carrà, A; Macaluso, V; Spezia, R; Villalta, PW | 1 |
| Balducci, E; Leuzzi, R; Moramarco, F; Pansegrau, W; Pezzicoli, A; Salvini, L | 1 |
| Fujikane, R; Hidaka, M; Obayashi, Y; Oka, K; Ozaki, M; Rikitake, M | 1 |
| Chari, R; Chung, HJ; Evans, CN; Fetsch, P; Filie, A; Hassan, R; Jiang, Q; Khanal, M; Morrow, B; Murai, J; Pommier, Y; Raffeld, M; Rathkey, D; Roth, M; Sengupta, M; Thomas, A; Xi, L; Zhang, J | 1 |
| Abdu, K; Aiertza, MK; Craggs, TD; Margison, GP; Povey, AC; Senthong, P; Wilkinson, OJ; Williams, DM | 1 |
| Gao, Y; Peng, RW; Schmid, RA; Xu, D; Yang, H | 1 |
| Hassan, R; Murai, J; Pommier, Y; Sengupta, M | 1 |
| Bose, A; Choe, J; Lee, HT; Myong, S; Opresko, PL; Paul, T; Sanford, S | 1 |
| Ghaem Maghami, M; Höbartner, C; Lenz, AK; Scheitl, CPM | 1 |
| Chen, SH; Chou, CL; Fang, CW; Hsiao, SY; Huang, WT; Kao, WC; Li, CF; Pan, HY; Shiue, YL | 1 |
| de Groot, JF; Gao, F; Koul, D; Li, X; Wu, S; Yung, WKA | 1 |
| Christensen, K; Clemmensen, S; Hjelmborg, J; Li, S; Li, W; Lund, J; Mengel-From, J; Mohammadnejad, A; Soerensen, M; Tan, Q; Timofeeva, M; Wang, L | 1 |
| Cui, L; Li, J; Liu, C; Lv, Y; Mou, Y; Song, X; Tian, R; Wu, X; Yang, X; Yang, Y; Yao, Y | 1 |
| Boldorini, R; Carriero, A; Cavalieri, S; Cossandi, C; Krengli, M; Masini, L; Stecco, A | 1 |
| Li, Q; Wang, C; Xiong, Y; Zhang, D; Zhang, R | 1 |
| Cao, D; Huang, W; Su, Y; Xing, Z; Yang, X; Zhou, X | 1 |
| Bao, L; Kumar, A; Luo, W; Wang, C; Wang, Y; Xing, C; Yang, M; Zhou, M | 1 |
| Hiddinga, B; Janssens, A; Pauwels, P; Van Meerbeeck, J; Zwaenepoel, K | 1 |
| Chen, Z; Fu, H; Ma, L; Qi, L | 1 |
| Li, Y; Liu, MH; Yang, XY; Yu, WT; Zhang, CY; Zhang, Y | 1 |
| Alimbetov, DS; Brown, KTG; Chen, Y; Cropper, JD; Guerra, JT; He, B; Kurmasheva, RT; Kwon, Y; Likhotvorik, RI; Robles, AJ | 1 |
39 review(s) available for o-(6)-methylguanine and guanine
| Article | Year |
|---|---|
Repair of DNA containing O6-alkylguanine.
Topics: Amino Acid Sequence; Animals; DNA Damage; DNA Repair; Guanine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Sequence Homology, Nucleic Acid | 1992 |
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
Topics: Alkylating Agents; Animals; CHO Cells; Cricetinae; DNA Damage; Drug Tolerance; Gene Expression Regulation, Neoplastic; Guanine; HeLa Cells; Humans; Methylation; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase | 1992 |
The role of O-6 methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibition.
Topics: Animals; DNA Repair; Drug Resistance; Ethylnitrosourea; Guanine; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Rats; Streptozocin | 1991 |
Site-specific mutagenesis: retrospective and prospective.
Topics: Animals; DNA; DNA Damage; Guanine; Humans; Mutagenesis; Neoplasms; Thymine | 1991 |
The role of carcinogen DNA adduct structure in the induction of mutations.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; DNA; DNA Adducts; DNA Damage; Guanine; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Thymine | 1990 |
Repair of O6-methylguanine damage in normal human tissues.
Topics: Animals; Carcinogens; Cell Cycle; DNA Damage; DNA Repair; Guanine; Humans; Mutagens | 1990 |
The influence of dietary restriction on DNA repair in rodents: a preliminary study.
Topics: Animals; DNA; DNA Repair; Energy Intake; Guanine; Methyl Methanesulfonate; Mice; Mice, Inbred Strains; Rats; Rats, Inbred BN; Rats, Inbred F344; Ultraviolet Rays | 1989 |
Methylated purines formed in DNA by dimethylnitrosamine in rats previously exposed to hepatotoxic and hepatocarcinogenic regimes: effects on the repair of O6-methylguanine.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Dimethylnitrosamine; DNA; DNA Repair; Ethanolamines; Guanine; Liver; Male; Quinoxalines; Rats; Rats, Inbred Strains | 1985 |
The role of O6-methylguanine in human cell killing, sister chromatid exchange induction and mutagenesis: a review.
Topics: Adenoviridae; Base Composition; Cell Survival; DNA Repair; DNA, Viral; Guanine; Humans; Methylnitronitrosoguanidine; Mutation; Sister Chromatid Exchange | 1987 |
Relevance of N-nitrosamines to esophageal cancer in China.
Topics: Ascorbic Acid; China; DNA; Epidemiologic Methods; Esophageal Neoplasms; Esophagus; Female; Gastric Juice; Guanine; Humans; Hyperplasia; Nitrosamines; Pregnancy; Time Factors | 1986 |
Mechanisms of carcinogenesis induced by alkylating agents.
Topics: Alkylating Agents; Alkylation; Animals; Cells, Cultured; Cricetinae; Deoxyribonucleotides; DNA; DNA Repair; Escherichia coli; Guanine; Mice; Mutagens; Mutation; Neoplasms; Oncogenes; Rats | 1985 |
The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures.
Topics: Alkylating Agents; Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Haplorhini; Kidney; Liver; Mammals; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mice; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Placenta; Rats | 1985 |
Enzymology of repair of DNA adducts produced by N-nitroso compounds.
Topics: Alkylation; Animals; Base Sequence; Cells, Cultured; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Nitroso Compounds | 1984 |
Enhanced repair of O6-alkylguanine in mammalian tissues.
Topics: 2-Acetylaminofluorene; Adenine; Aflatoxin B1; Aflatoxins; Alkylating Agents; Alkylation; Animals; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Gerbillinae; Guanine; Hepatectomy; Liver; Methylnitrosourea; Mice; Rats; Rodentia; Species Specificity | 1984 |
High-performance liquid chromatography of nucleotides, nucleosides and bases.
Topics: Animals; Breast Neoplasms; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Deficiency Diseases; Female; Fluorouracil; Guanine; Humans; Inosine Monophosphate; Lesch-Nyhan Syndrome; Leukemia; Nucleosides; Nucleotides; Sarcoma 180; Skin; Thioinosine | 1981 |
[Molecular mechanisms of adaptation of cells to low levels of carcinogenic agents (author's transl)].
Topics: Adaptation, Physiological; Alkylating Agents; Alkylation; Animals; Carcinogens; DNA, Bacterial; Escherichia coli; Eukaryotic Cells; Fibroblasts; Guanine; Humans; Methylnitronitrosoguanidine; Mutation; Rats | 1982 |
Variability in DNA repair and individual susceptibility to genotoxins.
Topics: Animals; Antineoplastic Agents, Alkylating; DNA; DNA Repair; Environmental Exposure; Genetic Predisposition to Disease; Guanine; Hodgkin Disease; Humans; Melanoma; Methyltransferases; Mutagens; O(6)-Methylguanine-DNA Methyltransferase | 1995 |
DNA damage tolerance, mismatch repair and genome instability.
Topics: Animals; Bacterial Proteins; Base Sequence; CHO Cells; Colonic Neoplasms; Cricetinae; DNA Damage; DNA Repair; DNA, Satellite; Escherichia coli; Female; Fungal Proteins; Genome; Guanine; Humans; Male; Mammals; Methylation; Methyltransferases; Molecular Sequence Data; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Sister Chromatid Exchange | 1994 |
O6-methylguanine in DNA inhibits DNA replication and stimulates DNA repair synthesis in vitro.
Topics: DNA; DNA Repair; DNA Replication; Guanine; HeLa Cells; Humans | 1994 |
Mammalian cells defective in DNA mismatch correction.
Topics: Adenine Phosphoribosyltransferase; Animals; DNA Repair; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Mutation; Nucleic Acid Heteroduplexes | 1994 |
Embryotoxicity induced by alkylating agents: 7. Low dose prenatal-toxic risk estimation based on NOAEL risk factor approach, dose-response relationships, and DNA adducts using methylnitrosourea as a model compound.
Topics: Abnormalities, Drug-Induced; Algorithms; Alkylating Agents; Alkylation; Animals; DNA; DNA Damage; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethyl Methanesulfonate; Female; Fetal Death; Guanine; Methylnitrosourea; Mice; Models, Theoretical; Pregnancy; Risk Factors; Toxicology | 1993 |
Molecular dosimetry of chemical mutagens. Relationship between DNA adduct formation and genetic changes analyzed at the molecular level.
Topics: Alkylation; Animals; Cells, Cultured; DNA Adducts; DNA Damage; DNA Repair; Guanine; Humans; Mice; Mutagens; Mutation | 1996 |
Genetic instability and methylation tolerance in colon cancer.
Topics: Cell Transformation, Neoplastic; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Damage; DNA Repair; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1996 |
Genomic instability and tolerance to alkylating agents.
Topics: Antineoplastic Agents, Alkylating; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Adducts; DNA Damage; DNA Methylation; DNA Repair; Guanine; Humans; Methyltransferases; Microsatellite Repeats; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Platinum | 1996 |
DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinogens, Environmental; Dimethylnitrosamine; DNA Adducts; DNA Damage; DNA Methylation; Erythrocebus patas; Ethanol; Female; Guanine; Humans; Leukocytes; Liver; Mice; Mice, Transgenic; Neoplasms; Nitroso Compounds; Procarbazine | 1997 |
Repair of DNA lesion O6-methylguanine in hepatocellular carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; DNA Repair; Guanine; Humans; Liver Cirrhosis; Liver Neoplasms; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase | 1998 |
Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents.
Topics: Alkylating Agents; Animals; Cell Survival; DNA; DNA Damage; DNA Repair; Guanine; Humans; Mesylates; Methylnitronitrosoguanidine; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 2000 |
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase.
Topics: Alkylation; Amino Acid Sequence; Amino Acid Substitution; Archaeal Proteins; Arginine; Bacterial Proteins; Binding Sites; Cysteine; DNA Damage; DNA Repair; Evolution, Molecular; Guanine; Helix-Turn-Helix Motifs; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Protein Binding; Protein Conformation; Sequence Alignment; Sequence Homology, Amino Acid | 2000 |
[Repair of alkylated DNA and consequences of its failure].
Topics: Alkylating Agents; Animals; Base Pair Mismatch; Cloning, Molecular; DNA Damage; DNA Repair; Gene Deletion; Guanine; Humans; Methylation; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 2001 |
DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes.
Topics: Alkylation; Animals; Carbon-Oxygen Lyases; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Damage; DNA Glycosylases; DNA Ligases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Flap Endonucleases; Guanine; Humans; Models, Molecular; N-Glycosyl Hydrolases; Protein Binding; Protein Conformation; Pyrophosphatases; Uracil-DNA Glycosidase | 2001 |
BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis.
Topics: Alkylation; Animals; Apoptosis; Base Pair Mismatch; Carbon-Oxygen Lyases; CHO Cells; Cricetinae; Cricetulus; Deoxyribonuclease IV (Phage T4-Induced); DNA Adducts; DNA Damage; DNA Glycosylases; DNA Polymerase beta; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Guanine; Humans; Mammals; Methylation; Mice; Mice, Knockout; Mutagenesis; Mutagens; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Oxidants; Oxidation-Reduction; Phosphorylation; Protein Processing, Post-Translational; Transfection | 2001 |
Health span and life span in transgenic mice with modulated DNA repair.
Topics: Age of Onset; Alkylating Agents; Animals; Brain; Carcinogens; DNA Damage; DNA Repair; DNA, Complementary; Enzyme Induction; Female; Guanine; Liver; Liver Neoplasms, Experimental; Longevity; Lung; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Recombinant Fusion Proteins; Transferrin; Transgenes | 2001 |
Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine.
Topics: Alkylating Agents; Animals; DNA; DNA Adducts; DNA Damage; DNA Methylation; Guanine; Humans; Neoplasms; Point Mutation; Recombination, Genetic | 2002 |
DNA repair in resistance to alkylating anticancer drugs.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents, Alkylating; DNA Repair; Drug Resistance, Neoplasm; Guanine; Neoplasms | 2002 |
MGMT: a personal perspective.
Topics: Alkylating Agents; Animals; Cloning, Molecular; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Escherichia coli; Guanine; History, 20th Century; History, 21st Century; Humans; Methylnitronitrosoguanidine; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Tumor Suppressor Proteins | 2007 |
DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Death; DNA; DNA Adducts; DNA Damage; DNA Repair; Guanine; Humans; Inhibitor of Apoptosis Proteins; Neoplasms; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Radiation, Ionizing; Signal Transduction; Survivin | 2013 |
Gene markers in brain tumors: what the epileptologist should know.
Topics: Biomarkers; Brain Neoplasms; CpG Islands; DNA Methylation; Epilepsy; Guanine; Humans; Mutation; Tumor Suppressor Proteins | 2013 |
Clinicopathological significance and potential drug target of O6-methylguanine-DNA methyltransferase in colorectal cancer: a meta-analysis.
Topics: Colorectal Neoplasms; DNA Methylation; Gene Expression Regulation, Neoplastic; Guanine; Humans; Mutation; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic | 2015 |
Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; DNA Adducts; DNA Mismatch Repair; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Mutation; Neoplasm Recurrence, Local | 2017 |
3 trial(s) available for o-(6)-methylguanine and guanine
| Article | Year |
|---|---|
O6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: results of a phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Female; Guanine; Humans; Male; Melanoma; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2000 |
A Phase III study of radiation therapy (RT) and O⁶-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; DNA Methylation; Female; Glioblastoma; Gliosarcoma; Guanine; Humans; Male; Middle Aged; Radiotherapy; Young Adult | 2015 |
Frequency of O⁶-methylguanine-DNA methyltransferase promoter methylation in cytological samples from small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Dacarbazine; DNA Methylation; Glioma; Guanine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Small Cell Lung Carcinoma; Temozolomide | 2015 |
685 other study(ies) available for o-(6)-methylguanine and guanine
| Article | Year |
|---|---|
DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by O(6)-methylguanine.
Topics: Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Polymerase I; Escherichia coli; Genetic Code; Guanine; Methylation; Methylnitrosourea; Polydeoxyribonucleotides; Sulfuric Acid Esters; Templates, Genetic; Thymidine Monophosphate | 1979 |
Increased excision of O6-methylguanine from rat liver DNA after chronic administration of dimethylnitrosamine.
Topics: Animals; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Rats | 1979 |
O6-methylguanine accumulates in DNA of mammary glands after administration of N-methyl-N-nitrosourea to rats.
Topics: Animals; Brain; DNA; DNA Repair; Female; Guanine; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats; Urinary Bladder | 1979 |
The excision of N-methyl-N-nitrosourea-induced lesions from the DNA of Chinese hamster cells as measured by the loss of sites sensitive to an enzyme extract that excises 3-methylpurines but not O6-methylguanine.
Topics: Animals; Cell Line; Cricetinae; Deoxyribonucleases; DNA; Guanine; Methylnitrosourea; Micrococcus; Nitrosourea Compounds; Purines; Structure-Activity Relationship | 1979 |
Immunological detection of O6-methylguanine in alkylated DNA.
Topics: Alkylation; Cross Reactions; DNA; Guanine; Radioimmunoassay; Structure-Activity Relationship | 1978 |
Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA.
Topics: Animals; Cattle; Depression, Chemical; Dimethylnitrosamine; DNA; Guanine; Kidney; Liver; Methylation; Nitrosamines; Rats | 1978 |
Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA; Female; Guanine; In Vitro Techniques; Kidney; Liver; Nitrosamines; Proteins; Rats | 1978 |
Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts.
Topics: Animals; Brain; Cattle; Chromatin; DNA; Guanine; Intestinal Mucosa; Kidney; Liver; Lung; Methylnitrosourea; Thymus Gland | 1978 |
Mutations induced by DNA lesions in hot spots of the c-Ha-ras gene.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Line, Transformed; DNA; DNA Damage; Genes, ras; Guanine; Hypoxanthine; Hypoxanthines; Mice; Molecular Sequence Data; Mutation; Xanthine; Xanthines | 1992 |
Reaction of O6-alkylguanine-DNA alkyltransferase with O6-methylguanine analogues: evidence that the oxygen of O6-methylguanine is protonated by the protein to effect methyl transfer.
Topics: Escherichia coli; Guanine; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oxygen; Protons | 1992 |
Mutagenesis by O6 meG residues within codon 12 of the human Ha-ras proto-oncogene in monkey cells.
Topics: Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Codon; Genes, ras; Genetic Vectors; Guanine; Humans; Methyltransferases; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Mas; Simian virus 40 | 1992 |
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
Topics: Animals; Carmustine; Drug Resistance; Female; Glioblastoma; Guanine; Humans; Male; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous | 1992 |
Fidelity of replication of the leading and the lagging DNA strands opposite N-methyl-N-nitrosourea-induced DNA damage in human cells.
Topics: Animals; Cell Line; DNA; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; DNA, Bacterial; Genes, Bacterial; Genetic Vectors; Guanine; Herpesvirus 4, Human; Humans; Kidney; Metallothionein; Methylnitrosourea; Mice; Mutagenesis; Plasmids; Promoter Regions, Genetic; Restriction Mapping; Transcription, Genetic; Transfection | 1992 |
Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas.
Topics: Alkalies; Alkylation; Animals; Antineoplastic Agents; Cell Division; Dacarbazine; DNA Damage; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Guanine; Leukemia L1210; Methyltransferases; Mice; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1992 |
Expression of the endogenous O6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions.
Topics: Adenine Phosphoribosyltransferase; Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; CHO Cells; Cricetinae; Exons; Frameshift Mutation; Guanine; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1992 |
Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells.
Topics: Animals; Base Sequence; Breast; Cell Transformation, Neoplastic; Cells, Cultured; Collagen; Culture Media; Epithelial Cells; Epithelium; Female; Guanine; Humans; Menopause; Methyltransferases; Mice; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1992 |
Accumulation of O6- and 7-methylguanine in DNA of N-nitroso-N-methylbenzylamine-treated rats is restricted to non-target organs for N-nitroso-N-methylbenzylamine-induced carcinogenesis.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Guanine; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1992 |
Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; Cells, Cultured; Cricetinae; DNA; Guanine; Liver; Liver Neoplasms; Male; Mesocricetus; Methylation; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344 | 1992 |
DNA adduct dosimetry and DNA repair in rats and pigs given repeated doses of procarbazine under conditions of carcinogenicity and human cancer chemotherapy respectively.
Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Damage; DNA Repair; Female; Guanine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Rats; Rats, Sprague-Dawley; Species Specificity; Swine | 1992 |
Structure-related properties of the mutagenic lesion 6-O-methylguanine in DNA.
Topics: Base Composition; Base Sequence; Deoxyribonucleases, Type II Site-Specific; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Repair; Guanine; Humans; Hydrogen Bonding; Hydroxylamine; Hydroxylamines; Methyltransferases; Molecular Sequence Data; Mutagenesis; Nucleic Acid Conformation; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides | 1992 |
Incision at O6-methylguanine:thymine mispairs in DNA by extracts of human cells.
Topics: Base Composition; Base Sequence; Binding, Competitive; Colonic Neoplasms; Deoxyribonuclease I; DNA; DNA Repair; Glioma; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Tumor Cells, Cultured | 1992 |
Relevance of environmental alkylating agents to repair protein O6-alkylguanine-DNA alkyltransferase: determination of individual and collective repair capacities of O6-methylguanine.
Topics: Automobiles; Bacteriophage lambda; DNA Repair; DNA, Viral; Female; Guanine; Humans; Lymphocytes; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Occupations; Phosphorus Radioisotopes; Reference Values; Substrate Specificity | 1992 |
Immunoaffinity purification combined with 32P-postlabelling for the detection of O6-methylguanine in DNA from human tissues.
Topics: Chromatography, Thin Layer; DNA; Guanine; Humans; Phosphorus Radioisotopes | 1992 |
Modulation of nitrosourea resistance in human colon cancer by O6-methylguanine.
Topics: Carmustine; Colonic Neoplasms; DNA Repair; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1992 |
Formation and repair of O6-methylguanine and methylation of the Ha-ras proto-oncogene by N-methyl-N-nitrosourea are not associated with mammary tumor resistance in the Copenhagen rat.
Topics: Animals; Blotting, Northern; Blotting, Southern; DNA Repair; DNA, Neoplasm; Drug Resistance; Female; Genes, ras; Guanine; Mammary Neoplasms, Experimental; Methylation; Methylnitrosourea; Rats | 1992 |
Cholecystokinin inhibits DNA alkylation induced by N-nitrosobis (2-oxopropyl)amine (BOP) in hamster pancreas.
Topics: Alkylation; Animals; Cholecystokinin; Cricetinae; DNA; Guanine; Liver Neoplasms; Nitrosamines; Pancreas; Sincalide | 1992 |
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Caffeine; Carcinogens; Catechin; Deoxyguanosine; DNA; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Tea | 1992 |
In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; DNA; DNA Repair; Doxorubicin; Female; Guanine; Hodgkin Disease; Humans; Injections, Intravenous; Leukocytes; Lymphoma, Non-Hodgkin; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Pilot Projects; Rats; Rats, Inbred Strains; Vinblastine; Vincristine | 1991 |
Preferential methylation of the Ha-ras proto-oncogene by methylnitrosourea in rat mammary glands.
Topics: Animals; Blotting, Northern; Blotting, Southern; DNA; Female; Genes, ras; Guanine; Mammary Glands, Animal; Methylation; Methylnitrosourea; Rats; Rats, Inbred BUF; Restriction Mapping; RNA; Transcription, Genetic | 1991 |
Relationship between the depletion of O6-methylguanine-DNA methyltransferase by O6-methylguanine and the stimulation of DNA synthesis and growth of cultured chick hepatocytes.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; DNA; Guanine; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1992 |
Mutagenicity in V79 cells of N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-oxopropyl)amine activated by tissues from hamsters fed low and high fat diets.
Topics: Alkylation; Animals; Carcinogens; Cell Line; Cricetinae; Dietary Fats; DNA; Guanine; Liver; Male; Mesocricetus; Mutagenesis; Mutagenicity Tests; Nitrosamines; Pancreatic Ducts | 1992 |
Kinetics of extension of O6-methylguanine paired with cytosine or thymine in defined oligonucleotide sequences.
Topics: Base Composition; Base Sequence; Cytosine; DNA-Directed DNA Polymerase; Escherichia coli; Guanine; Kinetics; Molecular Sequence Data; Mutagenesis; Oligonucleotides; Thymine | 1991 |
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.
Topics: Animals; Bacterial Proteins; CHO Cells; Cricetinae; DNA; Enzyme Activation; Escherichia coli Proteins; Guanine; Humans; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors; Transfection | 1991 |
The effects of Chinese tea on the methylation of DNA by the esophageal carcinogen N-nitrosomethylbenzylamine.
Topics: Animals; Anticarcinogenic Agents; Autoradiography; Dimethylnitrosamine; DNA; Esophageal Neoplasms; Guanine; Male; Methylation; Purine Nucleotides; Rats; Rats, Inbred Strains; Tea | 1991 |
Levels of O6-methylguanine acceptor protein in extracts of human breast tumor tissues.
Topics: Adult; Aged; Breast Neoplasms; Carrier Proteins; DNA Repair; DNA, Neoplasm; Female; Guanine; Humans; Male; Middle Aged; Neoplasm Proteins | 1991 |
Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.
Topics: Adenine; Alkylating Agents; Animals; Cytochrome b Group; DNA; Dose-Response Relationship, Drug; Glucagon; Glucose; Guanine; Immunoblotting; Insulin; Islets of Langerhans; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mitochondria; RNA, Messenger; Streptozocin | 1991 |
Site-dependent inhibition by single O6-methylguanine bases of SV40 T-antigen interactions with the viral origin of replication.
Topics: Animals; Antigens, Polyomavirus Transforming; Base Sequence; Binding Sites; Cell Line; DNA Helicases; DNA Replication; DNA, Viral; Guanine; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Simian virus 40 | 1991 |
Promutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA Damage; Guanine; Male; Neoplasms, Experimental; Rats | 1991 |
Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates.
Topics: Animals; Carcinogens; DNA; Guanine; Isothiocyanates; Mice; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiocyanates | 1991 |
Novel, sensitive assays for O6-alkylguanine and its repair and their application to studies of the molecular epidemiology of this lesion in human populations.
Topics: DNA Damage; DNA Repair; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1991 |
Rotation about the C6-O6 bond in O6-methylguanine: the syn and anti conformers can be of similar energies in duplex DNA as estimated by molecular modeling techniques.
Topics: Base Sequence; Carcinogens; DNA; Guanine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Heteroduplexes; Stereoisomerism; X-Ray Diffraction | 1991 |
Formation of DNA adducts in F-344 rats after oral administration or inhalation of [14C]methyl bromide.
Topics: Administration, Inhalation; Administration, Oral; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; DNA; Female; Gas Chromatography-Mass Spectrometry; Gastric Mucosa; Guanine; Hydrocarbons, Brominated; Liver; Lung; Male; Rats; Rats, Inbred F344; Sex Factors; Stomach | 1991 |
Beta-deuteration of N-nitrosoethylmethylamine causes a shift in DNA methylation from rat liver to esophagus.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Chromatography; Deuterium; Dimethylnitrosamine; DNA; Esophagus; Guanine; Kidney; Liver; Lung; Male; Methylation; Microsomes, Liver; Nitrosamines; Rats; Rats, Inbred F344 | 1991 |
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Female; Guanine; Hydroxylation; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1991 |
Embryotoxicity induced by alkylating agents: 6. DNA adduct formation induced by methylnitrosourea in mouse embryos.
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; DNA; DNA Repair; Embryo, Mammalian; Female; Guanine; Methylnitrosourea; Mice; Neoplasms, Experimental; Pregnancy | 1991 |
Nitrosamine-induced cancer: selective repair and conformational differences between O6-methylguanine residues in different positions in and around codon 12 of rat H-ras.
Topics: Animals; Bacterial Proteins; Base Composition; Base Sequence; Codon; DNA Repair; Escherichia coli; Escherichia coli Proteins; Genes, ras; Guanine; Kinetics; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Rats; Skin Neoplasms; Thermodynamics; Transcription Factors | 1991 |
Immunocytochemical localization of DNA adducts induced by a single dose of N-nitroso-N-methylbenzylamine in target and non-target tissues of tumor formation in the rat.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA Repair; DNA, Neoplasm; Guanine; Immunohistochemistry; Male; Methylation; Organ Specificity; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Transforming activity of a synthetic c-Ha-ras gene containing O6-methylguanine in codon 12.
Topics: 3T3 Cells; Adenine; Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; Codon; Genes, ras; Genes, Synthetic; Genetic Vectors; Guanine; Humans; Mice; Molecular Sequence Data; Mutagenesis, Insertional; Mutation; Oligonucleotides; Transfection | 1991 |
O6-methylguanine inhibits the binding of transcription factors to DNA.
Topics: Alkylation; Base Sequence; DNA; Guanine; HIV Long Terminal Repeat; Immunoblotting; Molecular Sequence Data; Transcription Factors | 1991 |
O6-methylguanine as a modulator of antitumor activity of N-alkyl-N-nitrosoureas in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA Damage; DNA, Neoplasm; Drug Interactions; Drug Resistance; Guanine; Leukemia L1210; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Nucleic Acid Conformation; Time Factors | 1991 |
The role of O6-alkylguanine in cell killing and mutagenesis in Chinese hamster ovary cells.
Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Cricetinae; DNA Repair; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Transfection | 1991 |
Mutagenic frequencies of site-specifically located O6-methylguanine in wild-type Escherichia coli and in a strain deficient in ada-methyltransferase.
Topics: Base Sequence; DNA Repair; Escherichia coli; Guanine; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase | 1991 |
Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases.
Topics: Base Sequence; Carcinogens; DNA Damage; DNA Repair; Escherichia coli; Guanine; Humans; Methyltransferases; Molecular Sequence Data; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Thymine | 1991 |
Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.
Topics: Animals; Base Sequence; Codon; Dimethylnitrosamine; DNA; Drug Resistance; Gene Expression Regulation, Neoplastic; Genes, ras; Guanine; Incidence; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Molecular Sequence Data; Mutation; Nitrosamines; Proto-Oncogenes; Thymine; Time Factors | 1991 |
Enzymatic methylation of cytosine in DNA is prevented by adjacent O6-methylguanine residues.
Topics: Base Sequence; Cytosine; DNA-Cytosine Methylases; DNA, Bacterial; Guanine; Methylation; Micrococcus; Molecular Sequence Data | 1991 |
Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene.
Topics: Animals; Dietary Proteins; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Gene Expression; Guanine; Liver; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Time Factors | 1991 |
Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells.
Topics: Animals; Cell Line; DNA Repair; Escherichia coli; Genes, Bacterial; Guanine; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenesis; Plasmids; Polymerase Chain Reaction | 1991 |
Comparative mutagenesis of O6-methylguanine and O4-methylthymine in Escherichia coli.
Topics: Bacterial Proteins; Base Sequence; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Guanine; Molecular Sequence Data; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Thymidine; Transcription Factors | 1991 |
DNA methylation in specific cells of rat liver by N-nitrosodimethylamine and N-nitrosomethylbenzylamine.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Liver Neoplasms, Experimental; Male; Methylation; Rats; Species Specificity | 1991 |
Purification to homogeneity and partial amino acid sequence of a fragment which includes the methyl acceptor site of the human DNA repair protein for O6-methylguanine.
Topics: Amino Acid Sequence; Bacillus subtilis; Binding Sites; DNA Repair; Escherichia coli; Guanine; Humans; Lymphoma; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Sequence Homology, Nucleic Acid; Spleen; Substrate Specificity; Thrombocytopenia | 1990 |
Aneuploidy induction by alkylated bases and nucleosides in mammalian cells.
Topics: Adenine; Adenosine Deaminase; Alkylation; Aneuploidy; Animals; Cells, Cultured; Cricetinae; Cricetulus; DNA Damage; Guanine; Guanosine; Humans; Hypoxanthine Phosphoribosyltransferase; Methyltransferases; Models, Biological; Nucleosides; O(6)-Methylguanine-DNA Methyltransferase; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship | 1990 |
A new assay for O6-alkylguanine-DNA-alkyltransferase to determine DNA repair capacities using lambda-phage DNA as substrate.
Topics: Bacteriophage lambda; Base Sequence; DNA Repair; DNA, Viral; Escherichia coli; Guanine; Humans; Kinetics; Lymphocytes; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity | 1990 |
O6-methylguanine in place of guanine causes asymmetric single-strand cleavage of DNA by some restriction enzymes.
Topics: Base Sequence; Chromatography, High Pressure Liquid; DNA; DNA Restriction Enzymes; DNA, Single-Stranded; Electrophoresis, Polyacrylamide Gel; Guanine; Molecular Sequence Data; Oligodeoxyribonucleotides | 1990 |
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Drug Synergism; Guanine; Humans; Kidney; Kinetics; Liver; Lomustine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
O6-methylguanine in the SV40 origin of replication inhibits binding but increases unwinding by viral large T antigen.
Topics: Adenosine Triphosphate; Antigens, Viral; Antigens, Viral, Tumor; Base Sequence; Binding Sites; Binding, Competitive; DNA Helicases; DNA Replication; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Guanine; Molecular Sequence Data; Simian virus 40; Virus Replication | 1990 |
Effects of vanillin and o-vanillin on induction of DNA-repair networks: modulation of mutagenesis in Escherichia coli.
Topics: Benzaldehydes; DNA Repair; DNA, Bacterial; Escherichia coli; Gene Expression; Genes, Bacterial; Guanine; Methylnitrosourea; Mutation; Plasmids; SOS Response, Genetics; Ultraviolet Rays | 1990 |
Evidence that covalent complex formation between BCNU-treated oligonucleotides and E. coli alkyltransferases requires the O6-alkylguanine function.
Topics: Base Sequence; Carmustine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides | 1990 |
Evidence for spontaneous conversion of Mex- to Mex+ in human lymphoblastoid cells.
Topics: Cell Line; Cell Survival; Clone Cells; Gene Conversion; Guanine; Humans; Karyotyping; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1990 |
[The determination of DNA adducts in liver and lung of mice exposed to dimethylnitrosamine].
Topics: Animals; Dimethylnitrosamine; DNA; DNA Damage; Female; Guanine; Liver; Lung; Male; Mice | 1990 |
High-resolution structure of a mutagenic lesion in DNA.
Topics: Base Composition; Base Sequence; DNA; Guanine; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Genetic; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; X-Ray Diffraction | 1990 |
Interaction of oligonucleotides containing 6-O-methylguanine with human DNA (cytosine-5-)-methyltransferase [published erratumm appears in Biochemistry 1992 Aug 4;31(30):7008].
Topics: Base Composition; Base Sequence; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Guanine; Humans; Kinetics; Methylation; Molecular Sequence Data; Nucleotide Mapping; Oligonucleotides | 1990 |
Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine.
Topics: Crystallization; DNA; Guanine; Hydrogen Bonding; Magnesium; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; X-Ray Diffraction | 1990 |
Monoclonal antibody-based immunoassay for the determination of cellular enzymatic activity for repair of specific carcinogen-DNA adducts (O6-alkylguanine).
Topics: Alkylation; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Carcinogens; DNA; DNA Damage; DNA Repair; Guanine; Immunoassay; Kinetics; L Cells; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase; Plasmids | 1990 |
Studies in gastric carcinogenesis. IV. O6-methylguanine and its repair in normal and atrophic biopsy specimens of human gastric mucosa. Correlation of O6-alkylguanine-DNA alkyltransferase activities in gastric mucosa and circulating lymphocytes.
Topics: Adult; Aged; Atrophy; Biopsy; DNA; DNA Repair; Female; Gastric Mucosa; Guanine; Humans; Lymphocytes; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase | 1990 |
Accumulation of O6-methylguanine in human blood leukocyte DNA during exposure to procarbazine and its relationships with dose and repair.
Topics: Adult; Aged; DNA; DNA Repair; Dose-Response Relationship, Drug; Guanine; Humans; Leukocytes; Liver; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine | 1990 |
O6-methylguanine (O6-MeG) and cytotoxicity: reversion analysis involving an N-methyl-N'-nitro-N-nitrosoguanidine-sensitive, O6-MeG-DNA methyltransferase-deficient HeLa cell mutant.
Topics: Cell Survival; Clone Cells; DNA Damage; DNA Repair; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Purines | 1990 |
Solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine.
Topics: Base Sequence; Chemical Phenomena; Chemistry; Chromatography; Guanine; Methods; Molecular Sequence Data; Oligonucleotides | 1990 |
Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cell Line; DNA; Dose-Response Relationship, Drug; Guanine; Hyperplasia; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Metaplasia; Methylation; Microscopy, Electron; Nitrosamines; Nose Neoplasms; Olfactory Mucosa; Rats; Rats, Inbred F344 | 1990 |
Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice.
Topics: Adenoma; Animals; Carcinogens; Deuterium; DNA; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Structure-Activity Relationship | 1990 |
Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA.
Topics: Base Sequence; Cloning, Molecular; DNA; DNA Modification Methylases; DNA Repair; Electrophoresis, Polyacrylamide Gel; Guanine; HeLa Cells; Humans; Hygromycin B; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Restriction Mapping; Sequence Homology, Nucleic Acid; Transfection; Transformation, Genetic | 1990 |
Linkage between O6-methylguanine-DNA methyltransferase (O6-MT) activity and cellular resistance to antitumour nitrosoureas in cultured rat brain tumour cell strains.
Topics: Animals; Brain Neoplasms; Cell Line; Guanine; Humans; Methyltransferases; Nimustine; Nitrosourea Compounds; Rats | 1990 |
Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells.
Topics: Alkylation; Animals; Cell Line; Cell Survival; Clone Cells; Cricetinae; Cricetulus; DNA; DNA Repair; Drug Resistance; Female; Guanine; Kinetics; Methylnitrosourea; Ovary; Phenotype; Sister Chromatid Exchange; Thioguanine | 1990 |
O6-methylguanine and A.C and G.T mismatches cause asymmetric structural defects in DNA that are affected by DNA sequence.
Topics: Base Composition; Base Sequence; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Guanine; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Nucleic Acid Denaturation; T-Phages; Temperature | 1990 |
Activation of N-nitrosobis(2-oxopropyl)amine by liver and nasal mucosa tissue from intact and castrated male rats.
Topics: Animals; Guanine; Liver; Male; Methylation; Methyltransferases; Mutagens; Mutation; Nasal Mucosa; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Orchiectomy; Rats; Rats, Inbred Strains | 1990 |
Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae.
Topics: Cysteine; DNA Repair; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanine; Half-Life; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Substrate Specificity; Temperature | 1990 |
Analysis of repair processes by the determination of the induction of cell killing and mutations in two repair-deficient Chinese hamster ovary cell lines.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Animals; Bleomycin; Cell Line; Cricetinae; DNA Repair; Drug Resistance; Female; Fibroblasts; Guanine; Hypoxanthine Phosphoribosyltransferase; Mitomycin; Mitomycins; Mutagens; Ovary; Sodium-Potassium-Exchanging ATPase; Ultraviolet Rays | 1986 |
Enhancement of O6-methylguanine-DNA-methyltransferase activity induced by various treatments in mammalian cells.
Topics: Animals; Bleomycin; Cell Cycle; Cells, Cultured; Cisplatin; Cricetinae; DNA; Ellipticines; Enzyme Induction; Gamma Rays; Guanine; Hot Temperature; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Protein Biosynthesis; Rats; Ultraviolet Rays | 1986 |
Induction of rat liver O6-alkylguanine-DNA alkyltransferase by bleomycin.
Topics: Animals; Bleomycin; DNA Repair; DNA Replication; Female; Guanine; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1986 |
Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase.
Topics: Chromatography, High Pressure Liquid; Colonic Neoplasms; DNA; DNA Repair; Escherichia coli; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; RNA; RNA, Transfer; Substrate Specificity; Tumor Cells, Cultured | 1988 |
Promutagenic alkyl lesions are induced in the tissue DNA of animals treated with isoniazid.
Topics: Alkylation; Animals; DNA; DNA Damage; Guanine; Isoniazid; Liver; Lung; Male; Mice; Mutation; Rats; Rats, Inbred Strains; Staining and Labeling | 1988 |
Cell and tissue specific localization of O6-methylguanine in the DNA of rats given N-nitrosodimethylamine: effects of protein deficient and normal diets.
Topics: Alkylation; Animals; Cell Nucleus; Diethylnitrosamine; DNA; Guanine; Immunohistochemistry; Kidney; Liver; Male; Protein-Energy Malnutrition; Rats; Rats, Inbred Strains; Reference Values | 1989 |
The role of nucleotide pool alkylation in the induction of numerical chromosome aberrations.
Topics: Adenosine Deaminase; Alkylation; Aneuploidy; Chromosome Aberrations; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Nucleotides; Purine-Nucleoside Phosphorylase | 1989 |
Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells.
Topics: Carmustine; Cell Line; Cell Survival; DNA Probes; DNA Repair; DNA, Neoplasm; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Restriction Mapping; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Repair of O6-methylguanine by ABC excinuclease of Escherichia coli in vitro.
Topics: Bacterial Proteins; Base Composition; DNA Repair; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Guanine; Substrate Specificity | 1989 |
Reduced O6-methylguanine repair in fibroblast cultures from patients with lung cancer.
Topics: Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; DNA Repair; Female; Fibroblasts; Guanine; Humans; Lung Neoplasms; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase | 1989 |
Methylation of DNA by three N-nitroso compounds: evidence for sequence specific methylation by a common intermediate.
Topics: Base Sequence; Dimethylnitrosamine; DNA; DNA Restriction Enzymes; Guanine; Methylation; Methylnitrosourea; Nitrosamines; Nitroso Compounds; Plasmids; Polydeoxyribonucleotides | 1989 |
Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Line; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Female; Guanine; Humans; Lomustine; Mesylates; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Transplantation, Heterologous | 1989 |
Absence of DNA damage-mediated induction of human methyltransferase specific for precarcinogenic O6-methylguanine.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA Repair; Female; Fetus; Guanine; Humans; Kidney; Liver; Methylnitronitrosoguanidine; Methyltransferases; Pregnancy; Rats | 1989 |
Urinary O6-methylguanine excretion in the rat after O6-methylguanine but not N-methylnitrosourea administration.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; Guanine; Liver; Male; Mass Spectrometry; Methionine; Methylnitrosourea; Purines; Rats; Spectrophotometry, Ultraviolet | 1989 |
Measurement of the removal of O6-methylguanine and O4-methylthymine from oligodeoxynucleotides using an immunoprecipitation technique.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; Chromatography, High Pressure Liquid; Guanine; Humans; Male; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Precipitin Tests; Rats; Thymine | 1989 |
Cytotoxic and DNA-damaging effects of 1,2-bis(sulfonyl)hydrazines on human cells of the Mer+ and Mer- phenotype.
Topics: Alkylating Agents; Alkylation; Colonic Neoplasms; DNA Damage; DNA Repair; DNA, Neoplasm; Guanine; Humans; Hydrazines; Methylation; Methyltransferases; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Sulfones; Tumor Cells, Cultured | 1989 |
Excision repair of O6-methylguanine synthesized at the rat H-ras N-methyl-N-nitrosourea activation site and introduced into Escherichia coli.
Topics: Base Sequence; DNA Repair; Escherichia coli; Guanine; Methylnitrosourea; Molecular Sequence Data; Mutation; Proto-Oncogenes; Transfection | 1989 |
Immunocytochemical analysis of O6-alkylguanine shows tissue specific formation in and removal from esophageal and liver DNA in rats treated with methylbenzylnitrosamine, dimethylnitrosamine, diethylnitrosamine and ethylnitrosourea.
Topics: Animals; Carcinogens; Cell Nucleus; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; DNA Repair; Esophagus; Ethylnitrosourea; Female; Guanine; Immunoenzyme Techniques; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Substrate Specificity | 1989 |
Methyl methanesulphonate (MMS) is clearly mutagenic in S. typhimurium strain TA1535; a comparison with strain TA100.
Topics: DNA, Bacterial; Guanine; Methyl Methanesulfonate; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Species Specificity | 1989 |
Mutagenic specificity of alkylated and oxidized DNA bases as determined by site-specific mutagenesis.
Topics: DNA Mutational Analysis; DNA, Bacterial; Escherichia coli; Guanine; Mutation; Thymine | 1989 |
Repair of cytotoxic lesions introduced into DNA by methylating agents.
Topics: Alkylating Agents; Animals; Cell Survival; Cricetinae; DNA Damage; DNA Repair; Escherichia coli; Guanine | 1989 |
Separation of the SOS-dependent and SOS-independent components of alkylating-agent mutagenesis.
Topics: DNA Repair; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Guanine; Methylnitrosourea; Mutation; Phenotype; Plasmids; Restriction Mapping; Ribosomal Protein S9; SOS Response, Genetics | 1989 |
Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium.
Topics: Cysteine; DNA Repair; Escherichia coli; Guanine; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase; Salmonella typhimurium | 1989 |
Effect of 3' flanking neighbors on kinetics of pairing of dCTP or dTTP opposite O6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used.
Topics: Base Composition; Base Sequence; Cloning, Molecular; Deoxycytosine Nucleotides; DNA Polymerase I; Escherichia coli; Guanine; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligodeoxyribonucleotides; Templates, Genetic; Thymine Nucleotides | 1989 |
A novel, sensitive assay for O6-methyl- and O6-ethylguanine in DNA, based on repair by the enzyme O6-alkylguanine-DNA-alkyltransferase in competition with an oligonucleotide containing O6-methylguanine.
Topics: Animals; DNA; DNA Damage; DNA Repair; Escherichia coli; Guanine; In Vitro Techniques; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotides; Radioimmunoassay; Rats; Rats, Inbred Strains | 1989 |
Purification of the E. coli ogt gene product to homogeneity and its rate of action on O6-methylguanine, O6-ethylguanine and O4-methylthymine in dodecadeoxyribonucleotides.
Topics: Alkylating Agents; Amino Acids; Chromatography, High Pressure Liquid; Deoxyribonucleotides; DNA Repair; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; Genes, Bacterial; Guanine; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine | 1989 |
The role of O6-alkylguanine DNA alkyltransferase in limiting nitrosourea-induced sister chromatid exchanges in proliferating human lymphocytes.
Topics: Carmustine; Cell Cycle; DNA Damage; DNA Repair; Guanine; Humans; Lymphocyte Activation; Lymphocytes; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phytohemagglutinins; Sister Chromatid Exchange | 1989 |
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Topics: Adenoma; Animals; Cricetinae; Cyanates; Female; Guanine; Isocyanates; Isothiocyanates; Lung; Lung Neoplasms; Mice; Microsomes; Nitrosamines; Thiocyanates | 1989 |
Modulation of O6-alkylguanine-DNA alkyltransferase in rats following intravenous administration of O6-methylguanine.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Guanine; Injections, Intravenous; Metabolic Clearance Rate; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tissue Distribution | 1989 |
Purification and properties of O6-methylguanine-DNA-methyltransferase in human hepatic tissue.
Topics: Adult; Ammonium Sulfate; Cellulose; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; DNA; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; Liver; Male; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase | 1989 |
DNA isolation from small tissue samples using anion-exchange HPLC.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA; Guanine; Indicators and Reagents; Lymphocytes; Male; Methylation; Microchemistry; Nitrosamines; Organ Specificity; Rats; Rats, Inbred F344 | 1989 |
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Line; Cricetinae; Cricetulus; Female; Guanine; Kinetics; Lomustine; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mitoguazone; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transfection | 1989 |
Thermodynamic comparison of the base pairs formed by the carcinogenic lesion O6-methylguanine with reference both to Watson-Crick pairs and to mismatched pairs.
Topics: Base Composition; Carcinogens; Guanine; Oligodeoxyribonucleotides; Thermodynamics | 1989 |
O6-methylguanine-DNA methyltransferase content in human lymphocytes following surgical trauma.
Topics: Aged; Female; Guanine; Half-Life; Humans; In Vitro Techniques; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Postoperative Period; Serum Albumin; T-Lymphocytes | 1989 |
O6-ethylguanine carcinogenic lesions in DNA: an NMR study of O6etG.C pairing in dodecanucleotide duplexes.
Topics: Base Composition; Base Sequence; Carcinogens; Cytosine; DNA; Guanine; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides | 1989 |
Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.
Topics: Animals; Base Sequence; Cell Line; Chromosomes; DNA Repair; Genetic Vectors; Guanine; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Polymerase Chain Reaction; Transfection | 1989 |
Transfectant CHO cells expressing O6-alkylguanine-DNA-alkyltransferase display increased resistance to DNA damage other than O6-guanine alkylation.
Topics: Alkylation; Animals; Carmustine; Cell Survival; Cricetinae; Cricetulus; Deoxyribonuclease BamHI; Deoxyribonuclease EcoRI; DNA Damage; DNA Restriction Enzymes; Guanine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sulfuric Acid Esters; Thioguanine; Transfection; Ultraviolet Rays | 1987 |
Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
Topics: Cell Division; Cell Survival; Cross-Linking Reagents; DNA Damage; DNA Repair; Ethylnitrosourea; Guanine; Humans; Lomustine; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1988 |
[Circumvention of ACNU-resistance in rat glioma cells by pretreatment with O6-methylguanine].
Topics: Animals; Brain Neoplasms; Cell Survival; Drug Resistance; Drug Synergism; Enzyme Induction; Glioma; Guanine; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Inhibition of the hepatic O6-alkylguanine-DNA alkyltransferase in vivo by pretreatment with antineoplastic agents.
Topics: Animals; Antineoplastic Agents; DNA Damage; DNA Repair; Female; Guanine; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344 | 1989 |
The in vivo mutagenic frequency and specificity of O6-methylguanine in phi X174 replicative form DNA.
Topics: Bacteriophage phi X 174; Base Sequence; DNA Repair; DNA Replication; Genes, Viral; Guanine; Hydrogen Bonding; Mutation | 1986 |
In vivo effect of DNA repair on the transition frequency produced from a single O6-methyl- or O6-n-butyl-guanine in a T:G base pair.
Topics: Bacteriophage phi X 174; Base Composition; DNA Repair; DNA Replication; DNA, Viral; Guanine | 1988 |
Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli.
Topics: Alkylation; Bacterial Proteins; Binding Sites; Chromatography, High Pressure Liquid; DNA Repair; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genes, Regulator; Guanine; Kinetics; Poly dA-dT; Stereoisomerism | 1985 |
uvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174.
Topics: Bacterial Proteins; Bacteriophage phi X 174; Codon; DNA Repair; DNA, Viral; Escherichia coli; Genes, Viral; Guanine; Mutation; Rec A Recombinases | 1985 |
The intracellular signal for induction of resistance to alkylating agents in E. coli.
Topics: Alkylating Agents; Bacterial Proteins; Base Sequence; Binding Sites; Cysteine; DNA Repair; DNA, Bacterial; Drug Resistance; Enzyme Activation; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Guanine; Methylation; Methyltransferases; Peptide Hydrolases; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Transcription, Genetic | 1986 |
DNA-mediated transfer and expression of a human DNA repair gene that demethylates O6-methylguanine.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Repair; DNA Restriction Enzymes; Drug Resistance; Ethylnitrosourea; Female; Genes; Guanine; Humans; Liver; Methyltransferases; Mycophenolic Acid; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transformation, Genetic | 1985 |
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.
Topics: Alkylation; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Kinetics; Methylnitrosourea; Mutation; Thymine | 1988 |
Two classes of Bacillus subtilis mutants deficient in the adaptive response to simple alkylating agents.
Topics: Alkylating Agents; Bacillus subtilis; DNA Glycosylases; Genotype; Guanine; Kinetics; Mutation; N-Glycosyl Hydrolases; Nitroso Compounds; Species Specificity; Structure-Activity Relationship; Transduction, Genetic | 1986 |
Individual differences in DNA repair capacities in man.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylation; Cells, Cultured; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; DNA Repair; Guanine; Humans; Kinetics; Lymphocytes | 1987 |
Cytotoxicity, mutations and SCEs induced by methylating agents are reduced in CHO cells expressing an active mammalian O6-methylguanine-DNA methyltransferase gene.
Topics: 4-Nitroquinoline-1-oxide; Alkylation; Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Guanine; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Ouabain; Sister Chromatid Exchange | 1987 |
Acquisition of resistance to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in V79 cells through increased removal of O6-alkylguanine.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; DNA Repair; Drug Resistance; Guanine; Methyltransferases; Nimustine; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase | 1987 |
Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of O6-alkylguanine-DNA alkyltransferase.
Topics: Cell Survival; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Guanine; Humans; Leukemia, Myeloid, Acute; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1988 |
Phenobarbital: a non-genotoxic agent which induces the repair of O6-methylguanine from hepatic DNA.
Topics: 2-Acetylaminofluorene; Animals; DNA Repair; Guanine; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenobarbital; Rats; Thymine | 1988 |
Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells.
Topics: Animals; DNA Repair; Guanine; Kinetics; Lung; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1988 |
Sequence specificity of guanine alkylation and repair.
Topics: Base Sequence; Chromatography, High Pressure Liquid; DNA Repair; Guanine; In Vitro Techniques; Kinetics; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Structure-Activity Relationship | 1988 |
Selective inhibition of methylbenzylnitrosamine-induced formation of esophageal O6-methylguanine by dietary ellagic acid in rats.
Topics: Animals; Benzopyrans; Cattle; Chromatography, High Pressure Liquid; Diet; Dimethylnitrosamine; DNA; Ellagic Acid; Esophagus; Guanine; Male; Methylation; Rats; Rats, Inbred Strains | 1988 |
Induction of plasminogen activator by N-methyl-N'-nitro-N-nitrosoguanidine in mer+ and mer- human tumour cell strains.
Topics: Alkylation; Cell Cycle; DNA; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Plasminogen Activators; Tumor Cells, Cultured | 1988 |
Detection of O6-methylguanine in human DNA.
Topics: Alkylating Agents; DNA; Environmental Monitoring; Guanine; Humans; Radioimmunoassay | 1988 |
Liver DNA alkylation after a single carcinogenic dose of dimethylnitrosamine to newborn and adult CFW Swiss mice.
Topics: Alkylation; Animals; Animals, Newborn; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase; Oxidoreductases, N-Demethylating | 1988 |
Modulation of nitrosourea resistance in myeloid leukemias.
Topics: Carmustine; Cell Differentiation; Colony-Stimulating Factors; DNA Repair; Drug Resistance; Guanine; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methyltransferases; Neoplasm Proteins; Neoplastic Stem Cells; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1988 |
The role of structural water in the formation of nucleotide mispairs.
Topics: Adenine; Base Composition; Computer Simulation; Cytosine; DNA Damage; DNA Replication; Guanine; Magnetic Resonance Spectroscopy; Mutation; Nucleic Acid Conformation; Thermodynamics; Uracil; Water | 1987 |
Repair of synthetic oligonucleotides containing O6-methylguanine, O6-ethylguanine and O4-methylthymine, by O6-alkylguanine-DNA alkyltransferase.
Topics: Animals; Chromatography, High Pressure Liquid; DNA Repair; Escherichia coli; Guanine; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine | 1987 |
Immunocytochemical studies on the formation and repair of O6-alkylguanine in rat tissues.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Ethylnitrosourea; Guanine; Immunohistochemistry; Islets of Langerhans; Kidney Glomerulus; Liver; Male; Muscle, Smooth; Precancerous Conditions; Rats; Spermatogonia; Tissue Distribution | 1987 |
Role of formaldehyde hydrazone and catalase in hydrazine-induced methylation of DNA guanine.
Topics: Amines; Animals; Catalase; DNA; Formaldehyde; Guanine; Heterocyclic Compounds; Hydrazines; Hydrazones; Magnetic Resonance Spectroscopy; Male; Methimazole; Methylation; Rats; Rats, Inbred Strains | 1988 |
Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity.
Topics: DNA Repair; Guanine; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides | 1988 |
Inhibition by dietary ethanol of experimental colonic carcinogenesis induced by high-dose azoxymethane in F344 rats.
Topics: Alkylation; Animals; Azo Compounds; Azoxymethane; Colonic Neoplasms; Diet; DNA; Ethanol; Guanine; Male; Rats; Rats, Inbred F344 | 1988 |
Increased sensitivity of lymphocytes from patients with systemic autoimmune diseases to DNA alkylation by the methylating carcinogen N-methyl-N-nitrosourea.
Topics: Adult; Alkylation; Arthritis, Rheumatoid; Autoimmune Diseases; Behcet Syndrome; DNA Repair; Guanine; Humans; Lupus Erythematosus, Systemic; Lymphocyte Activation; Methylnitrosourea; Scleroderma, Systemic | 1988 |
Inactivation of O6-alkylguanine-DNA alkyltransferase in the rat liver due to an intraperitoneal administration of methylated DNA.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Structure-Activity Relationship | 1988 |
Factors regulating activation and DNA alkylation by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and nitrosodimethylamine in rat lung and isolated lung cells, and the relationship to carcinogenicity.
Topics: Alkylation; Animals; Antibodies; Benzoflavones; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Isoenzymes; Lung; Methylation; Nitrosamines; Rats | 1988 |
Deficient repair of O6-methylguanine in lymphocytes from rheumatoid arthritis families may be an acquired defect.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoimmune Diseases; DNA Repair; Female; Guanine; Humans; Lymphocytes; Male; Middle Aged; Pedigree | 1988 |
A theoretical study of the effect of methylation or ethylation at O6-guanine in the structure and energy of DNA double strands.
Topics: Alkylation; Base Sequence; Chemical Phenomena; Chemistry, Physical; Computer Simulation; DNA; Guanine; Hydrogen Bonding; Methylation; Molecular Conformation; Structure-Activity Relationship; Thermodynamics | 1988 |
The contribution of O6-methylguanine and methylphosphotriesters to the cytotoxicity of alkylating agents in mammalian cells.
Topics: Alkylating Agents; Animals; Cell Line; Cloning, Molecular; Cricetinae; DNA Damage; DNA Repair; Drug Resistance; Guanine; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Organophosphates; Organophosphorus Compounds; Structure-Activity Relationship; Transfection | 1988 |
DNA repair by articular chondrocytes. V. O6 methylguanine-acceptor protein activity in resting and cultured rabbit and human chondrocytes.
Topics: Aging; Animals; Cartilage, Articular; Cells, Cultured; DNA Repair; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Proteins; Rabbits; Species Specificity | 1987 |
DNA adducts as a dosimeter for risk estimation.
Topics: Alkylation; Animals; Carcinogens; DNA; DNA Damage; Dose-Response Relationship, Drug; Guanine; Lung; Nasal Mucosa; Nitrosamines; Rats; Rats, Inbred F344; Respiratory Tract Neoplasms; Risk | 1987 |
Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid.
Topics: Benzopyrans; DNA; Dose-Response Relationship, Drug; Ellagic Acid; Guanine; Methylation; Methylnitrosourea; Mutation; Spermidine | 1986 |
Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Chlorambucil; Colonic Neoplasms; Dacarbazine; DNA Repair; Dose-Response Relationship, Drug; Guanine; Humans; Imidazoles; Kinetics; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Methyltransferases; Mice; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide | 1987 |
Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine.
Topics: Base Composition; Cytidine; Guanine; Guanosine; Hydrogen Bonding; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Conformation; Mutagens | 1987 |
Comparative study on the indirect methylation of liver DNA guanine by the 1-carbon pool in hepatotoxicity.
Topics: Animals; Chemical Phenomena; Chemistry; Cricetinae; DNA; Formaldehyde; Guanine; Hydrazines; Liver; Liver Neoplasms, Experimental; Male; Mesocricetus; Methylation; Mice; Species Specificity | 1987 |
Genetic evidence for nucleotide excision repair of O6-alkylguanine in mammalian cells.
Topics: Alkylation; Animals; Cattle; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA; DNA Repair; Guanine; Humans; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Radioimmunoassay; Xeroderma Pigmentosum | 1987 |
Induction of rat liver O6-alkylguanine-DNA alkyltransferase following whole body X-irradiation.
Topics: Animals; Cell Nucleus; Cycloheximide; DNA Repair; Dose-Response Relationship, Radiation; Enzyme Induction; Female; Guanine; Kinetics; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Whole-Body Irradiation | 1986 |
O6-methylguanine mutation and repair is nonuniform. Selection for DNA most interactive with O6-methylguanine.
Topics: Alkylation; Ampicillin; Bacteriophages; Base Sequence; Chimera; DNA; DNA Repair; Escherichia coli; Guanine; Mutation; Oncogenes; Penicillinase | 1986 |
Mutant Escherichia coli Ada proteins simultaneously defective in the repair of O6-methylguanine and in gene activation.
Topics: Bacterial Proteins; DNA Repair; Escherichia coli; Escherichia coli Proteins; Genes; Genes, Bacterial; Guanine; Kinetics; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors | 1986 |
Genetic toxicology of O6 methylguanine.
Topics: Coliphages; DNA Repair; DNA, Single-Stranded; Escherichia coli; Genes; Guanine; Mathematics; Methylnitronitrosoguanidine; Models, Genetic; Mutation | 1986 |
Chinese hamster cells harbouring the Escherichia coli O6-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents.
Topics: Alkylating Agents; Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Escherichia coli; Guanine; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange | 1986 |
Repair of O6-alkylguanine during DNA synthesis in murine bone marrow hematopoietic precursors.
Topics: Animals; Bone Marrow; Bone Marrow Transplantation; DNA; DNA Repair; Guanine; Hematopoietic Stem Cells; Male; Methylnitrosourea; Methyltransferases; Mice; Mice, Inbred Strains; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1987 |
Mutagenesis and repair of O6-substituted guanines.
Topics: Coliphages; DNA Repair; DNA Replication; DNA, Single-Stranded; DNA, Viral; Escherichia coli; Guanine; Mutation | 1986 |
Proteolytic processing of the Ada protein that repairs DNA O6-methylguanine residues in E. coli.
Topics: Bacterial Proteins; DNA Repair; Escherichia coli; Escherichia coli Proteins; Guanine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Peptide Hydrolases; Protein Processing, Post-Translational; Transcription Factors | 1987 |
O6-methylguanine specifically induces AT----GC transition mutations.
Topics: 5-Methylcytosine; Adenine; Alkylation; Base Composition; Cytosine; DNA Damage; DNA, Bacterial; Escherichia coli; Guanine; Hypoxanthine; Hypoxanthines; Mutation | 1987 |
Tissue and cellular specificity for DNA adduct formation and persistence following in vivo exposure to chemicals.
Topics: Alkylation; Animals; Benzopyrenes; Carcinogens; DNA Damage; DNA Repair; Guanine; Guanosine; Lung; Nitrosamines; Tissue Distribution | 1987 |
The molecular dosimetry of DNA adducts formed by continuous exposure of rats to alkylating hepatocarcinogens.
Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Dimethylhydrazines; DNA Damage; Guanine; Liver; Rats; Thymine | 1987 |
Preliminary investigations of tissue specificity, species specificity, and strategies for identifying chemicals causing DNA adducts in human placenta.
Topics: Animals; DNA Damage; Female; Fetal Blood; Guanine; Humans; Leukocytes; Mice; Placenta; Pregnancy; Sister Chromatid Exchange; Smoking | 1987 |
Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Colony-Forming Units Assay; Cross-Linking Reagents; Drug Resistance; Drug Synergism; Guanine; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Nitrosourea Compounds; Semustine; Transplantation, Heterologous; Tumor Stem Cell Assay | 1987 |
Visualization of O6-methylguanine in target cell nuclei of dimethylnitrosamine-treated human pancreas by a murine monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Carbon Radioisotopes; Cell Nucleus; Dimethylnitrosamine; Guanine; Humans; Mice; Organ Culture Techniques; Pancreas | 1987 |
MNNG-induced partial phenotypic reversion of Mer- cells.
Topics: Alkylating Agents; DNA Repair; Drug Resistance; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Phenotype | 1987 |
Dietary zinc deficiency increases the methylbenzylnitrosamine-induced formation of O6-methylguanine in the esophageal DNA of the rat.
Topics: Animals; Deficiency Diseases; Dimethylnitrosamine; DNA; Esophageal Neoplasms; Esophagus; Guanine; Male; Mutation; Rats; Rats, Inbred Strains; Zinc | 1987 |
Differential sensitivities of transformed and untransformed murine cell lines to DNA cross-linking agents relative to repair of O6-methylguanine.
Topics: Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Viral; Cross-Linking Reagents; DNA Repair; Guanine; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase | 1987 |
Exogenous O6-methylguanine inhibits adduct removal and sensitizes human cells to killing by the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Cell Survival; Cells, Cultured; DNA Damage; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1987 |
Tumorigenic activity of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanol (iso-NNAL) and N'-nitrosonornicotine (NNN) on topical application to Sencar mice.
Topics: Administration, Topical; Animals; Carcinogens; DNA; DNA Damage; Guanine; Mice; Nicotiana; Nitrosamines; Plants, Toxic; Skin Neoplasms | 1987 |
Estrous cycle modification of rat uterine DNA alkylation by N-methyl-N-nitrosourea.
Topics: Alkylation; Animals; DNA Damage; DNA Repair; Estrus; Female; Guanine; Methylnitrosourea; Rats; Time Factors; Uterus | 1987 |
Specificity of O6-alkylguanine-DNA alkyltransferase.
Topics: Alkylation; Animals; Cattle; DNA Repair; Guanine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; RNA, Ribosomal; RNA, Transfer; Substrate Specificity; Thymine | 1987 |
Investigations on the molecular dosimetry of tobacco-specific N-nitrosamines.
Topics: Animals; DNA; Guanine; Hemoglobins; Humans; Liver; Lung; Mutagenicity Tests; Nasal Mucosa; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Tobacco, Smokeless | 1987 |
Molecular dosimetry of O6-methylguanine formation and cell toxicity in lung and nasal mucosa by 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Guanine; Lung; Nasal Mucosa; Nitrosamines; Rats; Rats, Inbred F344 | 1987 |
Synthesis and structural studies by nuclear magnetic resonance of dodecadeoxynucleotides containing O6-methylguanine, O6-ethylguanine and O4-methylthymine.
Topics: Guanine; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Thymine | 1987 |
Organ specificity, metabolism and reaction with DNA of aliphatic nitrosomethylalkylamines.
Topics: Animals; Carcinogens; DNA; Dose-Response Relationship, Drug; Esophagus; Guanine; Liver; Male; Methylation; Nitrosamines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Substrate Specificity | 1987 |
Investigations of the DNA-damaging activity of human gastric juice.
Topics: Animals; Deoxyguanosine; DNA Damage; DNA Repair; Gastric Acidity Determination; Gastric Juice; Guanine; Humans; Liver; Methyltransferases; Nitrites; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Radioimmunoassay; Rats | 1987 |
Radioimmunoassay used to detect DNA alkylation adducts in tissues from populations at high risk for oesophageal and stomach cancer.
Topics: Alkylation; China; DNA; Esophageal Neoplasms; Female; Guanine; Humans; Male; Nitrosamines; Radioimmunoassay; Risk Factors; Stomach Neoplasms | 1987 |
Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues.
Topics: Alkylating Agents; Animals; Brain; DNA; Guanine; Humans; Intestines; Liver; Male; Methyltransferases; Mice; Mice, Inbred Strains; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats; Risk; Species Specificity | 1986 |
Cell cycle-dependent modulation of O6-methylguanine-DNA methyltransferase in C3H/10T1/2 cells.
Topics: Animals; Cell Cycle; Cells, Cultured; DNA Repair; Embryo, Mammalian; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase | 1986 |
Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Alkylation; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Glioma; Guanine; Humans; Methylnitrosourea; Methyltransferases; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange; Tritium | 1986 |
Repair of oligodeoxynucleotides containing O6-methylguanine by O6-alkylguanine-DNA-alkyltransferase.
Topics: DNA Repair; Guanine; Humans; Hydrogen-Ion Concentration; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides | 1986 |
Effect of N-nitrosamines carcinogenic for oesophagus on O6-alkyl-guanine-DNA-methyl transferase in rat oesophagus and liver.
Topics: Alkylation; Animals; Cysteine; Dimethylnitrosamine; DNA; DNA Repair; DNA Replication; Esophageal Neoplasms; Esophagus; Guanine; Liver; Liver Neoplasms, Experimental; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1986 |
Selective repair of methylated purines in regions of chromatin DNA.
Topics: Animals; Chromatin; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Male; Methylation; Purines; Rats; Rats, Inbred Strains | 1986 |
Site-specific mutagenesis in vivo by single methylated or deaminated purine bases.
Topics: Base Sequence; Coliphages; DNA Repair; DNA Replication; DNA, Viral; Guanine; Hypoxanthine; Hypoxanthines; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1986 |
Transfer of the E. coli O6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Cell Survival; Cloning, Molecular; DNA Repair; Gene Expression Regulation; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Sister Chromatid Exchange; Transfection | 1986 |
Presence of O6-methylguanine acceptor protein in the tissues of different classes of vertebrates and invertebrates.
Topics: Amphibians; Animals; Birds; Brain; Digestive System; Female; Fishes; Guanine; Kidney; Liver; Male; Mammals; Ovary; Proteins; Reptiles; Species Specificity; Spleen; Testis | 1986 |
Modifying effects of disulfiram on DNA adduct formation and persistence of benzaldehyde in N-nitroso-N-methyl-benzylamine-induced carcinogenesis in rats.
Topics: Animals; Benzaldehydes; Carcinogens; Dimethylnitrosamine; Disulfiram; DNA Repair; DNA, Neoplasm; Esophagus; Female; Guanine; Hyperplasia; Rats; Respiratory System; Respiratory Tract Neoplasms | 1986 |
Enhanced repair of O6-methylguanine in liver DNA of rats pretreated with phenobarbital, 2,3,7,8-tetrachlorodibenzo-p-dioxin, ethionine, or N-alkyl-N-nitrosoureas.
Topics: Alkylation; Animals; Dioxins; DNA; DNA Repair; Ethionine; Guanine; Liver; Male; Methionine; Nitrosourea Compounds; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1986 |
Established cell lines from nonmammalian vertebrates: models for DNA repair studies.
Topics: Amphibians; Animals; Birds; Cell Line; DNA Repair; Fishes; Guanine; Pyrimidine Dimers; Reptiles | 1986 |
Comparative studies on hepatic DNA alkylation in rats by N-nitrosomethylethylamine and N-nitrosodimethylamine plus N-nitrosodiethylamine.
Topics: Alkylation; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Male; Mathematics; Rats; Rats, Inbred F344 | 1986 |
Adaptive response to alkylating agents in mammalian cells.
Topics: Adaptation, Physiological; Alkylating Agents; Animals; Cell Survival; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1986 |
Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Alkylation; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Lung; Lung Neoplasms; Methyltransferases; Nicotiana; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Plants, Toxic; Rats; Rats, Inbred F344 | 1987 |
DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells.
Topics: Adenine; Alkylating Agents; Alkylation; Cell Survival; DNA Repair; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Purines; Sister Chromatid Exchange | 1987 |
Cell cycle-dependent initiation of hepatocarcinogenesis in rats by methyl(acetoxymethyl)nitrosamine.
Topics: Animals; Carcinogens; Cell Cycle; Cell Division; Dimethylnitrosamine; DNA Repair; DNA Replication; Guanine; Hepatectomy; Hydrocortisone; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Time Factors | 1987 |
Methylation of DNA guanine during the course of induction of liver cancer in hamsters by hydrazine or dimethylnitrosamine.
Topics: Animals; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA; Guanine; Hydrazines; Liver; Liver Neoplasms, Experimental; Male; Mesocricetus; Methylation; Tissue Distribution | 1987 |
[DNA alkylation during endogenous synthesis of N-nitrosodimethylamine].
Topics: Alkylation; Animals; Dimethylamines; Dimethylnitrosamine; DNA; DNA Damage; Guanine; Kidney; Liver; Lung; Male; Rats; Sodium Nitrite | 1987 |
6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyeth
Topics: Cell Division; Cell Line; Cell Survival; DNA Repair; Guanine; Guanosine; Humans; Methyltransferases; Neoplasms, Experimental; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Xeroderma Pigmentosum | 1987 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair.
Topics: Burkitt Lymphoma; Cell Line; DNA Repair; Guanine; Guanosine; Humans; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thymidine Kinase | 1985 |
Levels of O6-methylguanine acceptor protein in tissues of rats and their relationship to carcinogenicity and aging.
Topics: Aging; Animals; Brain; Carrier Proteins; DNA Repair; Female; Guanine; Kidney; Liver; Male; Neoplasms; Organ Specificity; Rats; Rats, Inbred Strains; Spleen | 1985 |
Cloning of the E. coli O6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay.
Topics: Cloning, Molecular; DNA Repair; Escherichia coli; Genes, Bacterial; Guanine; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase; Organophosphates | 1985 |
The Escherichia coli O6-methylguanine-DNA methyltransferase does not repair promutagenic O6-methylguanine residues when present in Z-DNA.
Topics: DNA Repair; Escherichia coli; Ethidium; Guanine; Kinetics; Methylnitrosourea; Methyltransferases; Nucleic Acid Conformation; O(6)-Methylguanine-DNA Methyltransferase | 1985 |
Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.
Topics: Animals; Cell Line; DNA; DNA Repair; Escherichia coli; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Organ Specificity; Rats; Species Specificity; Substrate Specificity; Thymine | 1985 |
Extrachromosomal probes for mutagenesis by carcinogens: studies on the mutagenic activity of O6-methylguanine built into a unique site in a viral genome.
Topics: Base Sequence; Carcinogens; Coliphages; DNA Repair; Escherichia coli; Genes, Viral; Guanine; Mutagens; Mutation; Oligodeoxyribonucleotides | 1985 |
The effect of methylation of the 6 oxygen of guanine on the structure and stability of double helical DNA.
Topics: Base Composition; DNA; Guanine; Molecular Structure; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Thermodynamics | 1985 |
Bacillus subtilis mutants deficient in the adaptive response to simple alkylating agents.
Topics: Alkylating Agents; Bacillus subtilis; DNA Repair; Guanine; Methylnitronitrosoguanidine; Mutation | 1985 |
Effects of butylated hydroxyanisole on the tumorigenicity and metabolism of N-nitrosodimethylamine and N-nitrosopyrrolidine in A/J mice.
Topics: Animals; Anisoles; Biotransformation; Butylated Hydroxyanisole; Dimethylnitrosamine; Female; Glutathione; Glutathione Transferase; Guanine; Lung; Lung Neoplasms; Mice; Microsomes; Microsomes, Liver; N-Nitrosopyrrolidine; Nitrosamines | 1986 |
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA, Neoplasm; Guanine; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats | 1986 |
Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; DNA; Guanine; Liver; Lung; Male; Methyltransferases; Nasal Mucosa; Nicotiana; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Plants, Toxic; Rats; Rats, Inbred F344; Respiratory System; Thymidine | 1986 |
Studies on the distribution of O6-methylguanine-DNA methyltransferase in rat.
Topics: Animals; Cell Nucleus; DNA Repair; Guanine; Liver; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Spleen; Subcellular Fractions; Tissue Distribution | 1986 |
The competitive miscoding of O6-methylguanine and O6-ethylguanine and the possible importance of cellular deoxynucleoside 5'-triphosphate pool sizes in mutagenesis and carcinogenesis.
Topics: Deoxyribonucleotides; DNA Polymerase I; DNA Replication; Guanine; Mutation; Templates, Genetic | 1986 |
Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.
Topics: Cell Survival; DNA Repair; Ethylnitrosourea; Fibroblasts; Guanine; Humans; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity | 1986 |
Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines--studies of the kinetics of removal of O6-methylguanine and 3-methyladenine.
Topics: Adenine; Autoimmune Diseases; Carcinogens; Cell Line; DNA Repair; Guanine; Humans; Kinetics; Lymphocytes; Mathematics; Models, Chemical | 1986 |
Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of alkyltriazenylimidazoles.
Topics: Alkylation; Antineoplastic Agents; Cell Line; Colonic Neoplasms; DNA; DNA Repair; Guanine; Humans; Triazenes | 1986 |
Repair of O4-methyldeoxythymidine residues in DNA by mammalian liver extracts.
Topics: Animals; Chromatography, High Pressure Liquid; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; Guanine; In Vitro Techniques; Liver; Macaca; Thymidine; Tissue Extracts | 1985 |
Genotoxicity of formaldehyde in cultured human bronchial fibroblasts.
Topics: Bronchi; Cells, Cultured; DNA Repair; Drug Synergism; Fibroblasts; Formaldehyde; Guanine; Humans; Methylnitrosourea; Mutagens | 1985 |
Formation of O6-methylguanine in rat liver DNA by nitrosamines does not predict initiation of preneoplastic foci.
Topics: Animals; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Liver Neoplasms, Experimental; Male; Methylation; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
The cytotoxic and mutagenic effects of alkylating agents on human lymphoid cells are caused by different DNA lesions.
Topics: Alkylating Agents; Alkylation; Cell Line; Cell Survival; DNA; Guanine; Humans; Lymphocytes; Methylnitronitrosoguanidine; Methyltransferases; Mutagens; O(6)-Methylguanine-DNA Methyltransferase | 1985 |
Repair of O6-methylguanine, by mammalian cell extracts, in alkylated DNA and poly(dG-m5dC).(poly dG-m5dC) in B and Z forms.
Topics: Alkylation; Animals; DNA Repair; Guanine; Liver Neoplasms, Experimental; Methylnitrosourea; Methyltransferases; Nucleic Acid Conformation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1985 |
Human tumor cell strains both unable to repair O6-methylguanine and hypersensitive to killing by human alpha and beta interferons.
Topics: Brain Neoplasms; Cell Line; Cell Survival; DNA Repair; Guanine; Humans; In Vitro Techniques; Interferon Type I | 1985 |
Improved fluorometric method for quantitative high-performance liquid chromatographic analysis of methylated guanine derivatives in DNA.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; DNA; Female; Guanine; Hydrolysis; Liver; Methylnitrosourea; Particle Size; Rats; Spectrometry, Fluorescence; Thymus Gland | 1985 |
Modulation of repair of O6-methylguanine in parenchymal and nonparenchymal liver cells of rats treated with dimethylnitrosamine.
Topics: Alkylation; Animals; Carbon Radioisotopes; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Liver Neoplasms; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1985 |
Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents.
Topics: Cell Division; DNA Repair; Guanine; HeLa Cells; Humans; Lomustine; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Time Factors | 1985 |
In vitro DNA methylation by methylnitrosourea in isolated copper- or silver-preloaded rat liver nuclei.
Topics: Animals; Cell Nucleus; Copper; DNA; Guanine; In Vitro Techniques; Liver; Male; Methylation; Methylnitrosourea; Rats; Rats, Inbred Strains; Silver | 1985 |
Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.
Topics: Female; Guanine; HeLa Cells; Humans; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1985 |
Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Cell Line; Fibroblasts; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Skin | 1985 |
Cell proliferation and DNA repair in the liver during early stages of chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Cycle; Cell Division; Clone Cells; DNA Repair; Guanine; Liver; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Phosphoglycerate Kinase; Precancerous Conditions; Rats; Rats, Inbred Strains; X Chromosome | 1985 |
DNA sequence has an effect on the extent and kinds of alkylation of DNA by a potent carcinogen.
Topics: Adenine; Alkylation; Animals; Base Sequence; Cattle; DNA; Guanine; Methylnitrosourea; Polydeoxyribonucleotides; Structure-Activity Relationship; Thymus Gland; Tritium | 1985 |
Relationships between DNA adduct formation and carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; DNA Replication; Environmental Exposure; Guanine; Humans; Liver; Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Risk | 1985 |
Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens.
Topics: Animals; Carcinogens; Cells, Cultured; Chromatography, Ion Exchange; Cricetinae; DNA; Escherichia coli; Guanine; Guanosine; Hydrogen-Ion Concentration; Methyl Ethers; RNA; Thymidine; Tritium | 1973 |
In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.
Topics: Coliphages; DNA Repair; DNA, Viral; Escherichia coli; Genetic Vectors; Guanine; Mutation | 1984 |
Defective repair of 0(6)-methylguanine in autoimmune diseases.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Disease Susceptibility; DNA Repair; Guanine; Humans; Lupus Erythematosus, Systemic; Lymphocytes; Mutation | 1982 |
Chronic or acute administration of various dialkylnitrosamines enhances the removal of O6-methylguanine from rat liver DNA in vivo.
Topics: Animals; Chromatography, Gel; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Nitrosamines; Purines; Rats; RNA | 1982 |
The kinetics of DNA alkylation, repair and replication in hepatocytes, Kupffer cells, and sinusoidal endothelial cells in rat liver during continuous exposure to 1,2-dimethylhydrazine.
Topics: Alkylation; Animals; Carboxylic Ester Hydrolases; Dimethylhydrazines; DNA; DNA Repair; DNA Replication; Guanine; Kinetics; Kupffer Cells; Liver; Male; Methylhydrazines; Microscopy, Electron, Scanning; Microscopy, Phase-Contrast; Phagocytosis; Rats; Staining and Labeling | 1983 |
[The same alkyl acceptor acts in the repair of DNA containing O6-methylguanine or O6-ethylguanine].
Topics: Alkylation; Animals; Chromatin; DNA Repair; Guanine; Liver; Nucleoproteins; Rats | 1984 |
In vivo replication of carcinogen-modified rat liver DNA: increased susceptibility of O6-methylguanine compared to N-7-methylguanine in replicated DNA to S1-nuclease.
Topics: Animals; Dimethylnitrosamine; DNA Replication; Endonucleases; Guanine; Liver; Male; Methylation; Rats; Single-Strand Specific DNA and RNA Endonucleases; Substrate Specificity | 1980 |
Construction and characterization of extrachromosomal probes for mutagenesis by carcinogens: site-specific incorporation of O6-methylguanine into viral and plasmid genomes.
Topics: Base Sequence; Carcinogens; DNA Restriction Enzymes; DNA, Recombinant; Genes, Viral; Guanine; Mutagens; Mutation; Plasmids | 1984 |
Enzymatic removal of mutagenic and lethal lesions from alkylated DNA.
Topics: Alkylation; Cell Line; DNA; DNA Repair; Escherichia coli; Guanine; Humans; Methylnitronitrosoguanidine; Mutation; S-Adenosylmethionine | 1983 |
Non-alcohol dehydrogenase-mediated metabolism of methylazoxymethanol in the deer mouse, Peromyscus maniculatus.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Azo Compounds; Carbon Radioisotopes; DNA; Guanine; Isotope Labeling; Kinetics; Liver; Methylazoxymethanol Acetate; Peromyscus; Pyrazoles | 1984 |
Base-pairing properties of O6-methylguanine in template DNA during in vitro DNA replication.
Topics: Animals; Base Composition; Cattle; DNA; DNA Polymerase I; DNA Replication; DNA-Directed DNA Polymerase; Escherichia coli; Guanine; Kinetics; Poly T; Polydeoxyribonucleotides; T-Phages; Templates, Genetic; Thymus Gland | 1984 |
Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli.
Topics: Animals; DNA Repair; Escherichia coli; Guanine; Liver; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Poly T; Polydeoxyribonucleotides; Rats; Thymine | 1984 |
Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Adaptation, Physiological; Bacillus subtilis; Drug Resistance, Microbial; Enzyme Induction; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1983 |
Saturation of repair system for O6-methylguanine in rat liver DNA by pretreatment with cyclic nitrosamines.
Topics: Animals; Binding Sites; Cyclization; Dimethylnitrosamine; DNA Repair; Female; Guanine; Liver; Nitrosamines; Rats; Rats, Inbred Strains | 1984 |
The effects of neighboring bases on N-methyl-N-nitrosourea alkylation of DNA.
Topics: Alkylation; Animals; Cattle; DNA; Guanine; Methylnitrosourea; Nitrosourea Compounds; Polydeoxyribonucleotides; Structure-Activity Relationship; Thymus Gland | 1984 |
Repair of O6-methylguanine in human fetal brain and skin cells in culture.
Topics: Alkylation; Brain; Cells, Cultured; DNA Repair; Fetus; Guanine; Humans; Kinetics; Skin | 1984 |
O6-Methylguanine-DNA transmethylase converts O6-methylguanine thymine base pairs to guanine thymine base pairs in DNA.
Topics: Base Composition; DNA Repair; Guanine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine | 1984 |
Synthesis and characterization of a set of four dodecadeoxyribonucleoside undecaphosphates containing O6-methylguanine opposite adenine, cytosine, guanine, and thymine.
Topics: Base Composition; Base Sequence; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Circular Dichroism; DNA; Drug Stability; Guanine; Methylation; Oligodeoxyribonucleotides; Oligonucleotides; Thermodynamics | 1984 |
Repair and replication of DNA containing O6-methylguanine in fetal and adult animal tissues in relation to their susceptibilities to cancer induction by N-nitroso-N-alkylureas.
Topics: Animals; Brain; Carcinogens; DNA Repair; DNA Replication; Female; Fetus; Guanine; Liver; Lung; Methylnitrosourea; Mice; Mice, Inbred C57BL; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Spleen; Thymus Gland | 1984 |
Methylated DNA adducts in the large intestine of ICR/Ha and C57BL/Ha mice given 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disease Susceptibility; DNA; Guanine; Intestine, Large; Methylation; Methylhydrazines; Mice; Precancerous Conditions; Species Specificity; Time Factors | 1983 |
Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.
Topics: Antineoplastic Agents; Cell Line; DNA, Neoplasm; Ethylnitrosourea; Guanine; Humans; Kinetics; Leukemia, Lymphoid; Methylnitrosourea; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase | 1984 |
Cellular aspects of DNA repair.
Topics: Animals; Cell Line; DNA Repair; Guanine; Humans; Hybridization, Genetic; Mutation | 1983 |
Stability and capacity of dimethylnitrosamine-induced O6-methylguanine repair system in rat liver.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA Repair; DNA Replication; Guanine; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1983 |
Replication and demethylation of O6-methylguanine in DNA.
Topics: Animals; DNA; DNA Replication; Guanine; Humans; Polydeoxyribonucleotides | 1983 |
Evidence for indirect genetic damage as methylation of DNA guanine in response to cytotoxicity.
Topics: Animals; Carcinogens; DNA; Dose-Response Relationship, Drug; Guanine; Guinea Pigs; Hydrazines; Liver; Methylation; Mice; Rats; Rats, Inbred Strains | 1983 |
Mutagenic and genotoxic effects of O6-methylguanine: a revision.
Topics: Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; DNA; Guanine; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange; Thioguanine | 1984 |
Formation of O6-methylguanine in regenerating rat liver by N-nitrosomethylbenzylamine is not sufficient for initiation of preneoplastic foci.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Guanine; Kinetics; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1984 |
[Biochemical study of the position specificity of rat gastrointestinal cancer induced by MNNG].
Topics: Administration, Oral; Animals; Duodenal Neoplasms; Guanine; Jejunal Neoplasms; Methylnitronitrosoguanidine; Rats; Rats, Inbred Strains; Stomach Neoplasms | 1984 |
Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.
Topics: Alkylating Agents; Cell Line; Cell Survival; DNA Repair; Female; Guanine; Humans; Kinetics; Neoplasms; Nitrosourea Compounds; Structure-Activity Relationship; Ultraviolet Rays | 1984 |
Comparison of repair of O6-methylguanine produced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse and human cells.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; DNA Repair; Embryo, Mammalian; Female; Guanine; Humans; Kinetics; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Neoplasms; Neoplasms, Experimental; Species Specificity | 1984 |
Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Guanine; Humans; Liver; Methylation; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Structure-Activity Relationship | 1984 |
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Guanine; Methylnitrosourea; Neoplasms, Experimental | 1984 |
O6-Methylguanine-DNA transmethylase activity in extracts of human gastric mucosa.
Topics: Adult; Aged; DNA Repair; Female; Gastric Mucosa; Guanine; Humans; Male; Methyltransferases; Middle Aged; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Stomach Neoplasms | 1984 |
The capacity of rat hepatoma cell lines for O6-methylguanine-DNA repair correlates with their status of differentiation.
Topics: Animals; Cell Differentiation; Cell Line; DNA Repair; Guanine; Liver Neoplasms, Experimental; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1984 |
O6-methylguanine repair in liver cells in vivo: comparison between G1- and S-phase of the cell cycle.
Topics: Alkylation; Animals; Cell Cycle; DNA; DNA Repair; Guanine; In Vitro Techniques; Liver; Male; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1984 |
DNA methylation in maternal, fetal and neonatal rat tissues following perinatal administration of procarbazine.
Topics: Animals; Animals, Newborn; Biotransformation; DNA; Female; Fetus; Guanine; Liver; Methylation; Pregnancy; Procarbazine; Rats; Rats, Inbred Strains | 1984 |
O6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli.
Topics: Escherichia coli; Genes, Bacterial; Genes, Regulator; Guanine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1982 |
Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1.
Topics: Adenine; Aflatoxin B1; Aflatoxins; Animals; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Rats; Stimulation, Chemical | 1981 |
Effects of carcinogens and partial hepatectomy upon the hepatic O6-methylguanine repair system in mice.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cell-Free System; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Hepatectomy; Liver; Liver Regeneration; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Rats; Rats, Inbred Strains | 1982 |
Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.
Topics: Animals; Cations; Guanine; Hydrogen-Ion Concentration; Liver; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Subcellular Fractions; Time Factors; Tissue Distribution | 1983 |
DNA methylation by dimethylnitrosamine in the Mongolian gerbil (Meriones unguiculatus): indications of a deficient, noninducible hepatic repair system for O6-methylguanine.
Topics: Animals; Dimethylnitrosamine; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; Dose-Response Relationship, Drug; Gerbillinae; Guanine; Liver; Male; Methyltransferases; Time Factors | 1983 |
Regulation of O6-methylguanine-DNA methyltransferase levels in rat liver and kidney.
Topics: Animals; DNA (Cytosine-5-)-Methyltransferases; Female; Folic Acid; Guanine; Kidney; Liver; Male; Methyltransferases; Nephrectomy; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Sex Factors | 1983 |
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Topics: DNA Repair; DNA, Neoplasm; Female; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1983 |
Similar repair of O6-methylguanine in normal and ataxia-telangiectasia fibroblast strains. Deficient repair capacity of lymphoblastoid cell lines does not reflect a genetic polymorphism.
Topics: Ataxia Telangiectasia; Cell Line; Cell Survival; DNA Repair; Guanine; Humans; Kinetics; Lymphocytes; Methylation; Polymorphism, Genetic | 1983 |
Quantitation of O6-methylguanine-DNA methyltransferase in HeLa cells.
Topics: DNA Repair; Guanine; HeLa Cells; Humans; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1983 |
O6-methylguanine, but not N7-methylguanine or N3-methyladenine, induces gene mutations, sister-chromatid exchanges and chromosomal aberrations in Chinese hamster cells.
Topics: Adenine; Animals; Cells, Cultured; Chromosome Aberrations; Cricetinae; Crossing Over, Genetic; Dose-Response Relationship, Drug; Guanine; Karyotyping; Mutation; Sister Chromatid Exchange | 1983 |
O6-Methylguanine removal by competent and incompetent human lymphoblastoid lines from the same male individual.
Topics: Adenine; Cell Division; Cell Line; Chromosome Aberrations; Guanine; Humans; Karyotyping; Lymphocyte Activation; Lymphocytes; Male; Methylnitronitrosoguanidine | 1983 |
Specifically alkylated DNA fragments. Synthesis and physical characterization of d[CGC(O6Me)GCG] and d[CGT(O6Me)GCG].
Topics: Base Sequence; Circular Dichroism; DNA; Guanine; Indicators and Reagents; Methylation; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oligonucleotides; Structure-Activity Relationship; Temperature | 1983 |
Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen.
Topics: Anemia, Hemolytic, Autoimmune; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Species Specificity; Spleen; Thymoma; Thymus Neoplasms | 1983 |
Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.
Topics: Adenine; Animals; Brain; DNA; Female; Fetus; Guanine; Kidney; Liver; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Placenta; Pregnancy; Purines; Rats; Time Factors | 1983 |
Formation and subsequent repair of alkylation lesions in tissues of rodents treated with nitrosamines.
Topics: Alkylation; Animals; Cricetinae; Dimethylnitrosamine; DNA; DNA Repair; Female; Guanine; Hypophysectomy; In Vitro Techniques; Kidney; Liver; Male; Mesocricetus; Rats; Species Specificity; Thyroidectomy | 1980 |
Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine.
Topics: Blood Proteins; Child; DNA Repair; Female; Guanine; Humans; Leukemia, Lymphoid; Lymphocytes; Male; Methylation | 1982 |
Adaptive resynthesis of O6-methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Repair; Female; Guanine; Humans; Kinetics; Methylation; Methylnitronitrosoguanidine; Ovary; Protein Binding | 1982 |
Removal of O6-methylguanine from DNA by human liver fractions.
Topics: Animals; DNA; Guanine; Humans; Liver; Rats | 1982 |
Mutagenesis of bacteriophage T7 in vitro by incorporation of O6-methylguanine during DNA synthesis.
Topics: Alkylation; Base Sequence; DNA Repair; DNA Replication; DNA, Viral; Guanine; Mutation; T-Phages; Temperature | 1982 |
Changes in O6-methylguanine disappearance from rat liver DNA during chronic dimethylnitrosamine administration. A possible similarity between the system removing O6-methylguanine from DNA in rat liver and in Escherichia coli adapted to N-methyl-N'-nitro-N
Topics: Animals; Dimethylnitrosamine; DNA; DNA, Bacterial; Enzyme Induction; Escherichia coli; Female; Guanine; Liver; Methylnitronitrosoguanidine; Rats; Time Factors | 1980 |
Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.
Topics: Alkylation; Bacterial Proteins; Cysteine; DNA Repair; DNA, Bacterial; Escherichia coli; Guanine; Methylation; Methyltransferases | 1980 |
Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli.
Topics: Deoxyguanosine; Enzyme Induction; Escherichia coli; Guanine; Kinetics; Methylnitronitrosoguanidine; Polydeoxyribonucleotides | 1980 |
Role of the uvrE gene product and of inducible O6-methylguanine removal in the induction of mutations by N-methyl-N'-nitro-N-nitrosoguanidine in Escherichia coli.
Topics: Chloramphenicol; DNA Repair; DNA, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Ethyl Methanesulfonate; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Protein Biosynthesis; Ultraviolet Rays | 1980 |
Mismatch correction at O6-methylguanine residues in E. coli DNA.
Topics: DNA Repair; Escherichia coli; Guanine; Methylation; Methylnitronitrosoguanidine | 1982 |
A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA.
Topics: Alkylating Agents; DNA Repair; Escherichia coli; Guanine; Mutagens; Mutation | 1982 |
The adaptive response to alkylating agents: the removal of O6-methylguanine from DNA is not dependent on DNA polymerase-1.
Topics: Alkylating Agents; DNA Polymerase I; DNA Repair; DNA-Directed DNA Polymerase; DNA, Bacterial; Escherichia coli; Guanine; Mutagens; Mutation; Nitrosourea Compounds; Phenotype | 1982 |
Resistance of Salmonella typhimurium TA 1535 to O6-guanine methylation and mutagenesis induced by low doses of N-methyl-N'-nitro-N-nitrosoguanidine: an apparent constitutive repair activity.
Topics: Chromatography, High Pressure Liquid; DNA; DNA Repair; Dose-Response Relationship, Drug; Guanine; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutation; Salmonella typhimurium; Time Factors | 1982 |
Nondetection of O6-methylguanine in rat DNA following in vivo treatment with large doses of cimetidine alone or in combination with sodium nitrite.
Topics: Animals; Chromatography; Cimetidine; DNA; Gastric Mucosa; Guanidines; Guanine; Hydrogen-Ion Concentration; Intubation; Male; Nitrites; Radioimmunoassay; Rats; Rats, Inbred Strains; Sodium Nitrite | 1982 |
Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro.
Topics: Adenine; Animals; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Repair; Guanine; In Vitro Techniques; Methylation; S-Adenosylmethionine; Scintillation Counting; Spectrophotometry, Ultraviolet | 1982 |
Cell specificity in hepatocarcinogenesis: preferential accumulation of O6-methylguanine in target cell DNA during continuous exposure to rats to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromatography, High Pressure Liquid; Dimethylhydrazines; DNA; Guanine; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Methylhydrazines; Rats; Rats, Inbred F344 | 1982 |
Dose- and cell cycle-dependent O6-methylguanine elimination from DNA in regenerating rat liver after [14C]dimethylnitrosamine injection.
Topics: Adenine; Animals; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Guanine; Interphase; Liver; Liver Regeneration; Male; Rats | 1982 |
A common chromatin factor involved in the repair of O6-methylguanine and O6-ethylguanine lesions in DNA.
Topics: Alkylation; Animals; Chromatin; DNA Repair; Guanine; Liver; Rats | 1982 |
Nature of the constitutive and induced mammalian O6-methylguanine DNA repair enzyme.
Topics: Animals; Cysteine; Diethylnitrosamine; DNA Repair; Guanine; Liver; Rats; Time Factors | 1982 |
Excision of O6-methylguanine from DNA by human fibroblasts determined by a sensitive competition method.
Topics: DNA; Fibroblasts; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases | 1982 |
Adaptive increase of O6-methylguanine-acceptor protein in HeLa cells following N-methyl-N'-nitro-N-nitrosoguanidine treatment.
Topics: Binding Sites; Guanine; HeLa Cells; Humans; Kinetics; Methylnitronitrosoguanidine; Protein Binding | 1982 |
Effect of chronic ethanol diet on the replication, alkylation, and repair of DNA from hepatocytes and nonparenchymal cells following dimethylnitrosamine administration.
Topics: Alkylation; Animals; Cell Separation; Dimethylnitrosamine; DNA; DNA Repair; DNA Replication; Ethanol; Guanine; Liver; Male; Rats; Rats, Inbred F344 | 1982 |
Direct assay for O6-methylguanine-acceptor protein in cell extracts.
Topics: Binding Sites; Cell Extracts; DNA; Guanine; Humans; Lymphocytes; Methods; Proteins; Radioisotopes; Tissue Extracts | 1982 |
Repair of O6-methyl-guanine residues in DNA takes place by a similar mechanism in extracts from HeLa cells, human liver, and rat liver.
Topics: Animals; DNA; DNA Glycosylases; DNA Repair; Guanine; HeLa Cells; Humans; Liver; Methylation; Methylnitronitrosoguanidine; Methyltransferases; Molecular Weight; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Proteins; Rats | 1982 |
Kinetics of repair of O6-methylguanine in dna by O6-methylguanine-DNA methyltransferase in vitro and in vivo.
Topics: Animals; DNA Repair; Female; Guanine; Kinetics; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1982 |
Susceptibility of dimethylnitrosamine induced O6-methylguanine containing regions in in vivo replicated, hybrid rat liver DNA towards S1 nuclease.
Topics: Animals; Bromodeoxyuridine; Deoxyribonucleases; Dimethylnitrosamine; DNA; DNA Replication; Guanine; Liver; Male; Methylation; Nucleic Acid Hybridization; Rats | 1980 |
The use of radioimmunoassay to study the formation and disappearance of O6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA Repair; DNA, Satellite; Guanine; Liver; Male; Methylguanidine; Mice; Rabbits; Radioimmunoassay | 1980 |
Effect of methionine sulfoximine on methylation of guanine residues in astroglial transfer ribonucleic acids.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Guanine; Guanosine; Kinetics; Methionine Sulfoximine; Methylation; Neuroglia; Rats; RNA, Transfer | 1981 |
Effect of pretreatment of rats with N-methyl-N-nitrosourea on the repair of O(6)-methylguanine in liver DNA.
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; DNA Repair; Guanine; Male; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats | 1981 |
Effects of selenium on 1,2-dimethylhydrazine metabolism and DNA alkylation.
Topics: 1,2-Dimethylhydrazine; Alkylation; Animals; Dimethylhydrazines; DNA; Guanine; Male; Methylhydrazines; Rats; Rats, Inbred Strains; Selenium; Thymidine | 1981 |
A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.
Topics: Amino Acids; Animals; DNA; DNA Repair; Guanine; Kinetics; Liver; Male; Methylation; Methylnitrosourea; Mice; Mice, Inbred C57BL; Proteins | 1981 |
In vivo kinetics of O6-methylguanine and 7-methylguanine formation and persistence in DNA of rats treated with symmetrical dimethylhydrazine.
Topics: Animals; Brain; Colon; Dimethylhydrazines; DNA; Guanine; Half-Life; Kidney; Kinetics; Liver; Lung; Male; Methylation; Methylhydrazines; Pancreas; Rats; Rats, Inbred Strains | 1981 |
The formation and repair of O6-methylguanine in rat liver nucleolar DNA after dimethylnitrosamine administration studied by radioimmunoassay.
Topics: Animals; Cell Nucleolus; Deoxyguanosine; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Radioimmunoassay; Rats; Rats, Inbred Strains | 1981 |
O6-alkylguanine and structural modifications in liver DNA of dialkylnitrosamine-treated rats.
Topics: Animals; Dimethylnitrosamine; DNA; DNA Repair; DNA, Single-Stranded; Dose-Response Relationship, Drug; Female; Guanine; Liver; Nitrosamines; Rats; Rats, Inbred Strains | 1981 |
Effect of inhibitors of tumorigenesis on the formation of O6-methylguanine in the colon of 1,2-dimethylhydrazine-treated rats.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; DNA; Guanine; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1981 |
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.
Topics: Adolescent; Adult; Alkylating Agents; Ataxia Telangiectasia; Cell Division; Cells, Cultured; Child; DNA; DNA Repair; Female; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1981 |
The determination of O6-methyl- and 7-methylguanine in mouse liver DNA from dimethylnitrosamine-treated mice by high-performance liquid chromatography with UV absorbance detection.
Topics: Animals; Chromatography, High Pressure Liquid; Dimethylnitrosamine; DNA; Guanine; Hydrolysis; Liver; Mice; Spectrophotometry, Ultraviolet | 1981 |
Effect of partial hepatectomy on removal of O6-methylguanine from alkylated DNA by rat liver extracts.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA Repair; Female; Guanine; Hepatectomy; Liver; Liver Regeneration; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Proteins; Rats; Time Factors | 1981 |
Methylation of liver DNA guanine in hydrazine hepatotoxicity: dose-response and kinetic characteristics of 7-methylguanine and O6-methylguanine formation and persistence in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; DNA; Dose-Response Relationship, Drug; Guanine; Hydrazines; Kinetics; Liver; Male; Methylation; Rats | 1981 |
Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Guanine; Liver Extracts; Male; Methylation; Proteins; Rats; Rats, Inbred Strains; Thioacetamide; Time Factors | 1981 |
Limited capacity for the removal of O6-methylguanine and its regeneration in a human lymphoma line.
Topics: Burkitt Lymphoma; Carcinogens; Cell Line; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine | 1981 |
Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.
Topics: Animals; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Kidney; Liver; Lung; Male; Rats; Time Factors | 1980 |
Distribution and repair of O6-methylguanine in different fractions of rat liver DNA after dimethylnitrosamine administration.
Topics: Animals; Chromatin; Dimethylnitrosamine; DNA Repair; DNA, Single-Stranded; Guanine; Liver; Male; Methylation; Nucleic Acid Denaturation; Rats | 1980 |
Decreased excision of O6-methylguanine and N7-methylguanine during the S phase in 10T1/2 cells.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; DNA; Guanine; Interphase; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H | 1980 |
Methylation of DNA by N-nitroso-2-oxopropylpropylamine: formation of O6- and 7-methylguanine and studies on the methylation mechanism.
Topics: Animals; Carcinogens; DNA; Guanine; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Liver; Male; Methylation; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Rats | 1980 |
In vivo replication of hepatic deoxyribonucleic acid of rats treated with dimethylnitrosamine: presence of dimethylnitrosamine-induced O6-methylguanine, N7-methylguanine, and N3-methyladenine in the replicated hybrid deoxyribonucleic acid.
Topics: Adenine; Animals; Dimethylnitrosamine; DNA Replication; Guanine; Liver; Male; Nucleic Acid Hybridization; Rats | 1980 |
Metabolism of dimethylnitrosamine and subsequent removal of O6-methylguanine from DNA by isolated rat hepatocytes.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA; Female; Guanine; In Vitro Techniques; Liver; Methylnitrosourea; Rats | 1981 |
Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treated human fibroblasts.
Topics: Ataxia Telangiectasia; Cells, Cultured; DNA Repair; Dose-Response Relationship, Drug; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Mutation; Xeroderma Pigmentosum | 1981 |
Evidence that lipid peroxidation products bind to DNA in liver cells.
Topics: Animals; Antioxidants; Arachidonic Acid; Butylated Hydroxytoluene; Cell Nucleus; Cell Survival; Deoxyribonuclease I; DNA; Ferrous Compounds; Guanine; Lipid Peroxidation; Lipid Peroxides; Liver; Male; Pentetic Acid; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Tritium; Vitamin E | 1995 |
On the quantitative relationship between O6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer- human tumor cell line.
Topics: Base Sequence; Cell Death; DNA; DNA Repair; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Mutagens; Mutation; Nucleic Acid Heteroduplexes; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange; Thioguanine; Tumor Cells, Cultured | 1994 |
Molecular dosimetry of 7-alkyl- and O6-alkylguanine in DNA by electrochemical detection.
Topics: Alkylating Agents; Animals; Chromatography, High Pressure Liquid; DNA; Electrochemistry; Guanine | 1994 |
Differential effects of procarbazine and methylnitrosourea on the accumulation of O6-methylguanine and the depletion and recovery of O6-alkylguanine-DNA alkyltransferase in rat tissues.
Topics: Animals; DNA; Female; Guanine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Proteins; Rats; Rats, Sprague-Dawley; RNA | 1994 |
Immunocytochemical identification of DNA adducts, O6-methylguanine and 7-methylguanine, in respiratory and other tissues of rat, mouse and Syrian hamster exposed to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Biotransformation; Carcinogens; Cell Nucleus; Cricetinae; DNA; DNA Adducts; DNA Damage; Guanine; Immunohistochemistry; Liver; Lung; Male; Mesocricetus; Methylation; Mice; Nasal Cavity; Nitrosamines; Rats; Rats, Sprague-Dawley; Respiratory System; Staining and Labeling; Trachea | 1994 |
Potentiation of the cytotoxicity of chloroethylnitrosourea by O6-arylmethylguanines.
Topics: Alkylation; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Drug Synergism; Glioma; Guanine; HeLa Cells; Humans; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Phenols; Prohibitins; Rats; Tumor Cells, Cultured | 1995 |
Sequence-selective DNA recognition and photocleavage: a comparison of enantiomers of Rh(en)2phi3+.
Topics: Base Sequence; Binding Sites; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Diamines; DNA; Ethylenediamines; Guanine; Hydrogen Bonding; Intercalating Agents; Molecular Sequence Data; Molecular Structure; Oligodeoxyribonucleotides; Organometallic Compounds; Photolysis; Stereoisomerism; Structure-Activity Relationship; Ultraviolet Rays | 1995 |
Dosimetry of O6-methylguanine in rat DNA after low-dose, chronic exposure to N-nitrosodimethylamine (NDMA). Implications for the mechanism of NDMA hepatocarcinogenesis.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; DNA Adducts; DNA Repair; Dose-Response Relationship, Drug; Female; Guanine; Kinetics; Liver; Liver Neoplasms, Experimental; Rats; Rats, Inbred WF; Time Factors; Water Supply | 1995 |
Induction of kinetochore-containing micronuclei by exogenous O6-methylguanine requires conversion of the methylated base to a nucleotide.
Topics: Adenine; Animals; Cell Line; Cricetinae; Cricetulus; Guanine; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Kinetochores; Methyl Methanesulfonate; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagens | 1995 |
Mouse methyltransferase for repair of O6-methylguanine and O4-methylthymine in DNA.
Topics: 3T3 Cells; Animals; Base Sequence; DNA Repair; DNA, Complementary; Guanine; HeLa Cells; Humans; Immunoblotting; Intracellular Fluid; Methylnitronitrosoguanidine; Methyltransferases; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity; Thymine | 1995 |
The development, validation and application of a 32P-postlabelling assay to quantify O6-methylguanine in human DNA.
Topics: Chromatography, Thin Layer; Deoxyguanosine; DNA; DNA Damage; Female; Guanine; Humans; Isotope Labeling; Male; Nucleotides; Phosphorus Radioisotopes; Reproducibility of Results | 1995 |
O6-methylguanine-induced replication blocks.
Topics: Base Sequence; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Magnesium; Manganese; Molecular Sequence Data | 1995 |
DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells.
Topics: Cells, Cultured; DNA Repair; Drug Tolerance; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae | 1995 |
Streptozotocin-induced toxicity in CHO-9 and V79 cells.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; DNA; DNA Replication; Ethylnitrosourea; Guanine; Methylnitrosourea; Mutagens; Streptozocin; Thymidine | 1995 |
Nonrandom distribution of O6-methylguanine in H-ras gene sequence from DNA modified with N-methyl-N-nitrosourea.
Topics: Animals; Base Sequence; DNA; Genes, ras; Guanine; Methylnitrosourea; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Rats | 1993 |
Synthesis of oligodeoxynucleotides containing analogs of O6-methylguanine and reaction with O6-alkylguanine-DNA alkyltransferase.
Topics: Base Sequence; Binding Sites; Glycosylation; Guanine; Hydrogen Bonding; Hydrolysis; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methyltransferases; Molecular Sequence Data; Nucleic Acid Conformation; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Structure-Activity Relationship; Substrate Specificity | 1994 |
Effects of dietary restriction and fasting on selected rat liver enzymes of xenobiotic metabolism and on AOM-induced DNA guanine methylation in rat liver and colon.
Topics: Aniline Hydroxylase; Animals; Azo Compounds; Benzopyrene Hydroxylase; Colon; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; DNA; Fasting; Food Deprivation; Glutathione Transferase; Guanine; Liver; Male; Methylation; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred F344; Xenobiotics | 1995 |
Defective repair of O6-methylguanine-DNA in primary Sjögren's syndrome patients predisposed to lymphoma.
Topics: Aged; Autoimmune Diseases; Cell Transformation, Neoplastic; DNA Repair; Female; Guanine; Humans; Lymphocytes; Lymphoma; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Sjogren's Syndrome | 1995 |
A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells.
Topics: Alkylating Agents; B-Lymphocytes; Cell Line; Chromosome Aberrations; Dimethylnitrosamine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Erythroid Precursor Cells; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1995 |
Site specificity of incisions at G:T and O6-methylguanine:T base mismatches in DNA by human cell-free extracts.
Topics: Base Composition; Base Sequence; Binding Sites; Binding, Competitive; Cell-Free System; DNA; Guanine; Humans; Molecular Sequence Data; Thymine; Tumor Cells, Cultured | 1995 |
A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.
Topics: Cell Survival; DNA Damage; DNA Repair; DNA, Neoplasm; DNA, Satellite; Dose-Response Relationship, Drug; Drug Resistance; Genetic Complementation Test; Guanine; HeLa Cells; Humans; Methylation; Methylnitrosourea; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thioguanine | 1995 |
Detection of O6-methylguanine, O4-methylthymine and O4-ethylthymine in human liver and peripheral blood leukocyte DNA.
Topics: Adolescent; Adult; Aged; Autopsy; DNA; DNA Adducts; Female; Guanine; Humans; Leukocytes; Liver; Male; Middle Aged; Thymine | 1995 |
Enhancement of ACNU cytotoxicity by pretreatment with O6-methylguanine in ACNU-resistant brain tumors.
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Cell Division; Densitometry; Drug Resistance; Drug Synergism; Guanine; Humans; Male; Neoplasm Transplantation; Nimustine; Rats; Rats, Wistar; Tetrazolium Salts; Thiazoles; Transplantation, Heterologous; Tumor Cells, Cultured | 1994 |
Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Basal Ganglia; Brain Neoplasms; Cell Count; Cell Division; Culture Techniques; DNA Repair; DNA, Neoplasm; Drug Synergism; Glioma; Guanine; Male; Nimustine; Rats; Rats, Wistar | 1994 |
Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats.
Topics: Animals; Cocarcinogenesis; DNA Damage; DNA Repair; Ethanol; Guanine; Injections, Intraperitoneal; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Orchiectomy; Rats; Rats, Sprague-Dawley | 1994 |
Construction and characterization of mutants of Salmonella typhimurium deficient in DNA repair of O6-methylguanine.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Repair; Dose-Response Relationship, Drug; Escherichia coli Proteins; Genes, Bacterial; Guanine; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Restriction Mapping; Salmonella typhimurium; Sequence Analysis, DNA; Sequence Deletion; Transcription Factors | 1995 |
Metabolism of N-nitrosomethylbenzylamine by microsomes from perivenous and periportal hepatocytes.
Topics: Animals; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; gamma-Glutamyltransferase; Guanine; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley | 1994 |
O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.
Topics: Adult; Biomarkers, Tumor; DNA Adducts; DNA Damage; DNA Repair; DNA, Neoplasm; Europe; Female; Gastritis, Atrophic; Guanine; Humans; Japan; Leukocytes; Male; Middle Aged; Pepsinogens; Prevalence; Risk Factors; Stomach Neoplasms | 1994 |
The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity.
Topics: Asparagine; Binding Sites; DNA; DNA Repair; Enzyme Stability; Glutamine; Guanine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity | 1994 |
O6-methylguanine-DNA adducts in rat lymphocytes after in vivo exposure to N-nitrosodimethylamine (NDMA).
Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Guanine; Immunoenzyme Techniques; Liver; Lymphocytes; Male; Methylation; Nitroso Compounds; Rats; Rats, Sprague-Dawley | 1994 |
Comparative study of mutagenesis by O6-methylguanine in the human Ha-ras oncogene in E. coli and in vitro.
Topics: Base Sequence; Codon; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Escherichia coli; Gene Transfer Techniques; Genes, ras; Genetic Vectors; Guanine; Humans; Kinetics; Molecular Sequence Data; Mutagenesis; Substrate Specificity | 1994 |
A deficiency for nucleotide excision repair strongly potentiates the mutagenic effectiveness of methyl bromide in Drosophila.
Topics: Alkylating Agents; Animals; Carcinogens; DNA Damage; DNA Repair; Drosophila melanogaster; Female; Genes, Lethal; Genes, Recessive; Guanine; Hydrocarbons, Brominated; Male; Mutagenicity Tests; Spermatozoa; X Chromosome | 1994 |
Immunocytochemical evidence for a nuclear and a cytoplasmic O6-methylguanine repair mechanism in cultured rat hepatocytes.
Topics: Animals; Antibodies, Anti-Idiotypic; Bacterial Proteins; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA Adducts; DNA Repair; Gold Colloid; Guanine; Immunohistochemistry; Liver; Methylnitronitrosoguanidine; N-Methylaspartate; Rats; Rats, Sprague-Dawley | 1994 |
Demethylation of O6-methylguanine in DNA by O6-methylguanine-DNA methyltransferase: synthesis and characterization of O6,9-dimethylguanine coordinated with cis-platin at the N7-position.
Topics: Animals; Cisplatin; DNA; DNA Damage; Guanine; Kinetics; Leukemia L1210; Methylation; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase; Organoplatinum Compounds | 1994 |
The susceptibility of inbred mice to the production of malignant thymoma by N-methyl-N-nitrosourea.
Topics: Age Factors; Animals; Guanine; Major Histocompatibility Complex; Methylnitrosourea; Mice; Mice, Inbred Strains; Species Specificity; Thymoma; Thymus Neoplasms | 1994 |
Relationships between the formation of O6-methyldeoxyguanosine by 1-p-carboxyl-3,3-dimethylphenyltriazene in DNA and O6-alkylguanine-DNA alkyltransferase in human peripheral leukocytes.
Topics: Adult; Aged; Antineoplastic Agents; Deoxyguanosine; DNA Nucleotidyltransferases; DNA, Neoplasm; Female; Guanine; Humans; Leukocytes; Lymphocytes; Male; Melanoma; Middle Aged; Triazenes | 1994 |
Hydralazine and other hydrazine derivatives and the formation of DNA adducts.
Topics: Alkylation; Animals; Chromatography, High Pressure Liquid; DNA; Dose-Response Relationship, Drug; Formaldehyde; Guanine; Hydralazine; Hydrazines; Liver; Male; Methylation; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley | 1994 |
Response of repair-competent and repair-deficient Escherichia coli to three O6-substituted guanines and involvement of methyl-directed mismatch repair in the processing of O6-methylguanine residues.
Topics: Base Sequence; Codon; DNA Repair; DNA Replication; Escherichia coli; Genes, Bacterial; Guanine; Methyltransferases; Models, Genetic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Plasmids | 1994 |
Comparative dosimetry of O6-methylguanine in humans and rodents treated with procarbazine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; DNA; Guanine; Hodgkin Disease; Humans; Leukocytes; Male; Mechlorethamine; Methyltransferases; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Prednisone; Procarbazine; Rabbits; Rats; Species Specificity; Vincristine | 1994 |
Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas.
Topics: Animals; DNA; DNA Repair; Guanine; Lymphoma; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Species Specificity; Thymus Gland; Thymus Neoplasms | 1994 |
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathione; Glutathione Transferase; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1994 |
Enhancing effect of O6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells.
Topics: Animals; Brain Neoplasms; Cell Survival; Drug Synergism; Guanine; HeLa Cells; Humans; Nimustine; Rats; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Deficient repair of DNA lesion O6-methylguanine in cirrhosis.
Topics: Biopsy; Carcinoma, Hepatocellular; Causality; Cell Division; Cell Transformation, Neoplastic; DNA Repair; Evaluation Studies as Topic; Guanine; Humans; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Lymphocytes; Mutagenesis; Risk Factors | 1993 |
Evidence supporting the role of DNA pyridyloxobutylation in rat nasal carcinogenesis by tobacco-specific nitrosamines.
Topics: Alkylation; Animals; Butanones; Carcinogens; Deuterium; DNA Damage; DNA, Neoplasm; Guanine; Male; Nasal Cavity; Nitrosamines; Nose Neoplasms; Olfactory Mucosa; Oxidation-Reduction; Pyridines; Rats; Rats, Inbred F344 | 1994 |
Repair resistance of O6-methylguanine in DNA of hamster fibroblasts expressing a bacterial alkyltransferase gene is dependent on chromatin structure.
Topics: Animals; Bacterial Proteins; Cell Nucleus; Chromatin; Clone Cells; Cricetinae; DNA; DNA Damage; DNA Repair; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Guanine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors; Transfection | 1993 |
A method for locating O6-methylguanine residues in DNA.
Topics: Base Sequence; DNA; Genetic Techniques; Guanine; Molecular Sequence Data | 1994 |
Crystal structure of a mispaired dodecamer, d(CGAGAATTC(O6Me)GCG)2, containing a carcinogenic O6-methylguanine.
Topics: Adenine; Base Composition; Base Sequence; Carcinogens; Crystallization; Crystallography, X-Ray; Guanine; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Software | 1994 |
Assay by inhibition of repair to measure O6-methylguanine in DNA.
Topics: Base Sequence; DNA; DNA Repair; Escherichia coli; Guanine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Radioimmunoassay | 1994 |
DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage.
Topics: Base Sequence; Dealkylation; DNA Damage; DNA Repair; Guanine; HeLa Cells; Humans; Methylation; Molecular Sequence Data; Protein Binding; Thioguanine; Tumor Cells, Cultured | 1994 |
Kinetic analysis of the coding properties of O6-methylguanine in DNA: the crucial role of the conformation of the phosphodiester bond.
Topics: Base Sequence; Cytosine; DNA; DNA Primers; Exodeoxyribonuclease V; Exodeoxyribonucleases; Guanine; Kinetics; Mathematics; Models, Theoretical; Molecular Sequence Data; Nucleic Acid Conformation; Templates, Genetic; Thymine | 1994 |
DNA adduct formation and assessment of aberrant crypt foci in vivo in the rat colon mucosa after treatment with N-methyl-N-nitrosourea.
Topics: Animals; Colon; Colonic Neoplasms; DNA; Dose-Response Relationship, Drug; Guanine; Intestinal Mucosa; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Time Factors; Tritium | 1994 |
Specificities of human, rat and E. coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA.
Topics: Animals; Bacterial Proteins; Base Sequence; DNA; DNA Repair; Escherichia coli; Escherichia coli Proteins; Guanine; Humans; Kinetics; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Rats; Substrate Specificity; Transcription Factors | 1994 |
Hydrazine genotoxicity in the neonatal rat.
Topics: Animals; Animals, Newborn; Base Sequence; Blotting, Southern; Chromatography, High Pressure Liquid; DNA; Formaldehyde; Guanine; Hydrazines; Liver; Molecular Sequence Data; Rats; Rats, Sprague-Dawley | 1994 |
Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains.
Topics: Animals; Base Sequence; DNA; Gene Expression; Genes, p53; Genes, ras; Guanine; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Polymerase Chain Reaction | 1993 |
Effect of alkyl sulfides on diazomethane-induced methylation of DNA in vitro.
Topics: Allyl Compounds; Animals; Cattle; Diazomethane; DNA; DNA Damage; Evaluation Studies as Topic; Guanine; Methylation; Sulfides | 1993 |
Genetic consequences of tolerance to methylation DNA damage in mammalian cells.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Aza Compounds; Base Sequence; Cell Survival; CHO Cells; Cricetinae; DNA; DNA Damage; Drug Resistance; Guanine; Methylation; Methylnitrosourea; Molecular Sequence Data; Mutation; Ouabain; Thioguanine | 1993 |
[DNA methylation of monohalogenated methanes of F344 rats].
Topics: Animals; Chromatography, High Pressure Liquid; DNA; Guanine; Hydrocarbons, Brominated; Hydrocarbons, Iodinated; Male; Methyl Chloride; Methylation; Rats; Rats, Inbred F344 | 1993 |
Chemical transformation/derivatization of O6-methyl- and O6-(hydroxyethyl)guanine for detection by GC-EC/MS.
Topics: Chromatography, Thin Layer; DNA; Electrons; Gas Chromatography-Mass Spectrometry; Guanine | 1993 |
O6-methylguanine in DNA inhibits replication in vitro by human cell extracts.
Topics: Antigens, Polyomavirus Transforming; Deoxyribonucleases, Type II Site-Specific; DNA Repair; DNA Replication; DNA, Viral; Guanine; HeLa Cells; Humans; Kinetics; Methylation; Methylnitrosourea; Plasmids; Simian virus 40 | 1993 |
Preclinical pharmacology of the antitumor agent O-6-methylguanine in CDF1 mice.
Topics: Animals; Blood Proteins; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Guanine; Half-Life; Humans; Injections, Intraperitoneal; Injections, Intravenous; Leukemia, Lymphoid; Mice; Protein Binding; Rats; Tumor Cells, Cultured | 1993 |
Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA Repair; Genes, p53; Guanine; Humans; Methylation; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1994 |
Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methylguanine-DNA methyltransferases.
Topics: Animals; DNA; DNA Repair; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Thymine | 1994 |
Accumulation of O6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects.
Topics: Animals; Dacarbazine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Guanine; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Procarbazine; Rats; Species Specificity | 1993 |
A highly sensitive and specific method for quantitation of O-alkylated DNA adducts and its application to the analysis of human tissue DNA.
Topics: Alkylating Agents; Alkylation; Chromatography, High Pressure Liquid; DNA; DNA Damage; Guanine; Humans; Leukocytes; Phosphorus Radioisotopes; Precipitin Tests; Sensitivity and Specificity; Thymine | 1993 |
Ellagic acid embryoprotection in vitro: distribution and effects on DNA adduct formation.
Topics: Abnormalities, Drug-Induced; Animals; DNA Damage; Ellagic Acid; Embryo, Mammalian; Guanine; Methylnitrosourea; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Solubility; Teratogens; Yolk Sac | 1993 |
Repair of O6-methylguanine in rat pancreatic beta-cells after exposure to N-methyl-N-nitrosourea.
Topics: Animals; Blotting, Northern; Cells, Cultured; CHO Cells; Cricetinae; Guanine; Islets of Langerhans; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Cells, Cultured | 1993 |
O6-methylguanine residues elicit DNA repair synthesis by human cell extracts.
Topics: Antibodies; Antigens, Polyomavirus Transforming; Cell Line; DNA; DNA Repair; Guanine; HeLa Cells; Humans; Kinetics | 1993 |
Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; DNA; DNA Repair; Guanine; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344; Thymidine | 1993 |
A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Death; Cell Division; CHO Cells; Cricetinae; DNA Damage; DNA Repair; Drug Hypersensitivity; Drug Resistance; Guanine; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Rats; Tumor Cells, Cultured | 1993 |
The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
Topics: Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Codon; DNA Damage; DNA Repair; Genes, ras; Guanine; Methyltransferases; Molecular Sequence Data; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Transfection | 1993 |
Inhibition by phenylethyl and phenylhexyl isothiocyanate of metabolism of and DNA methylation by N-nitrosomethylamylamine in rats.
Topics: Animals; Carcinogens; DNA; Esophagus; Guanine; Isothiocyanates; Liver; Methylation; Microsomes; Microsomes, Liver; Nitrosamines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiocyanates | 1993 |
Evidence from in vitro replication that O6-methylguanine can adopt multiple conformations.
Topics: Base Sequence; Calorimetry; DNA Polymerase I; DNA Replication; Escherichia coli; Guanine; Kinetics; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Oligodeoxyribonucleotides; Structure-Activity Relationship; Templates, Genetic | 1993 |
Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.
Topics: Alkylation; Animals; Cattle; DNA; DNA Repair; Guanine; Liver; Methylation; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines; Rats | 1993 |
The significance of DNA damage, its repair and cell proliferation during carcinogen treatment in the initiation of pancreatic cancer in the hamster model.
Topics: Alkylation; Animals; Carcinogens; Cell Division; Cricetinae; DNA; DNA Damage; DNA Repair; Female; Guanine; Mesocricetus; Nitrosamines; Pancreatic Neoplasms | 1993 |
Mutagenicity and mutational spectrum of N-methyl-N'-nitro-N-nitrosoguanidine in the hprt gene in G1-S and late S phase of diploid human fibroblasts.
Topics: Amino Acid Sequence; Aphidicolin; Base Sequence; Cell Cycle; Diploidy; DNA; DNA Replication; Fibroblasts; G1 Phase; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; S Phase; Sequence Analysis, DNA; Time Factors | 1993 |
Supplemental dietary calcium fails to alter the acute effects of 1,2-dimethylhydrazine on O6-methylguanine, O6-alkylguanine-DNA alkyltransferase and cellular proliferation in the rat colon.
Topics: Animals; Antimutagenic Agents; Biotransformation; Calcium; Cell Division; Colon; Diet; Dimethylhydrazines; Guanine; Immunohistochemistry; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas.
Topics: Animals; Bacterial Proteins; Base Sequence; Cell Survival; Clone Cells; Cricetinae; Drug Resistance; Escherichia coli; Fibroblasts; Gene Expression; Guanine; Lung; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Transfection | 1993 |
Factors influencing the repair of the mutagenic lesion O6-methylguanine in DNA by human O6-methylguanine-DNA methyltransferase.
Topics: Bacterial Proteins; Base Sequence; Chromatography; DNA Repair; Escherichia coli Proteins; Guanine; Humans; Kinetics; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Recombinant Fusion Proteins; Recombinant Proteins; Substrate Specificity; Transcription Factors | 1993 |
O6-methylguanine DNA adduct formation and modulation by ethanol in placenta and fetal tissues after exposure of pregnant patas monkeys to N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA Adducts; DNA Damage; Erythrocebus patas; Ethanol; Female; Fetus; Guanine; Maternal-Fetal Exchange; Placenta; Pregnancy | 1995 |
Structure of a new crystal form of a DNA dodecamer containing T.(O6Me)G base pairs.
Topics: Base Composition; Base Sequence; Crystallography, X-Ray; DNA; Guanine; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Oligodeoxyribonucleotides | 1995 |
Temporal cell-type-specific mRNA expression of O6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine.
Topics: Administration, Oral; Animals; Base Sequence; Blotting, Northern; Carcinogens; Dimethylnitrosamine; DNA Adducts; Guanine; Immunohistochemistry; In Situ Hybridization; Liver; Male; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Rats; RNA Probes; RNA, Messenger; Time Factors | 1996 |
Structure-function relationships of the dietary anticarcinogen ellagic acid.
Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Benzopyrene Hydroxylase; Ellagic Acid; Enzyme Induction; Glutathione Transferase; Guanine; Inactivation, Metabolic; NAD(P)H Dehydrogenase (Quinone); Structure-Activity Relationship | 1996 |
Comparative study of the formation and repair of O6-methylguanine in humans and rodents treated with dacarbazine.
Topics: Animals; Dacarbazine; DNA Damage; DNA Repair; Female; Guanine; Hodgkin Disease; Humans; Male; Methyltransferases; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity | 1996 |
Frequency of Ki-ras mutations and DNA alkylation in colorectal tissue from individuals living in Manchester.
Topics: Base Sequence; Colon; Colorectal Neoplasms; DNA Damage; DNA Primers; England; Genes, ras; Guanine; Humans; Methylation; Molecular Sequence Data; Point Mutation; Proto-Oncogene Proteins p21(ras) | 1996 |
O6-methylguanine levels and histopathological changes in the rat esophagus and liver following single and repeated administration of N-nitrosomethylbenzylamine.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Dose-Response Relationship, Drug; Esophagus; Guanine; Liver; Male; Rats; Rats, Inbred F344 | 1996 |
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
Topics: Adenosine Triphosphatases; Bacterial Proteins; Base Composition; Base Sequence; Cisplatin; Dinucleoside Phosphates; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Escherichia coli Proteins; Guanine; Humans; Molecular Sequence Data; MutS DNA Mismatch-Binding Protein; Protein Binding; Thymine | 1996 |
Replication of O6-methylguanine-containing DNA by repair and replicative DNA polymerases.
Topics: Base Sequence; DNA Adducts; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; DNA, Single-Stranded; Guanine; Humans; Molecular Sequence Data; Templates, Genetic; Viral Proteins | 1996 |
Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells.
Topics: Abietanes; Animals; Antioxidants; Butylated Hydroxytoluene; Cell Survival; DNA Adducts; DNA Damage; Drugs, Chinese Herbal; Guanine; Iron Chelating Agents; Lipid Peroxidation; Liver; Male; Malondialdehyde; Pentetic Acid; Phenanthrenes; Plant Extracts; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Superoxide Dismutase; Vitamin E | 1996 |
Measurement of oxidized and methylated DNA bases by HPLC with electrochemical detection.
Topics: Chromatography, High Pressure Liquid; DNA; DNA Damage; Electrochemistry; Guanine; Methylation; Oxidation-Reduction; Purines; Pyrimidines; Uracil | 1996 |
Satellite high-performance liquid chromatography for trace sample cleanup.
Topics: Chromatography, High Pressure Liquid; DNA; DNA Adducts; Gas Chromatography-Mass Spectrometry; Guanine; Reference Standards; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Time Factors | 1996 |
The Escherichia coli MutS DNA mismatch binding protein specifically binds O(6)-methylguanine DNA lesions.
Topics: Adenosine Triphosphatases; Bacterial Proteins; Base Sequence; Binding Sites; Cell Line; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Guanine; Humans; MutS DNA Mismatch-Binding Protein; Oligodeoxyribonucleotides | 1996 |
Alterations in DNA and cell membranes in an initiation process of carcinogenesis by N-nitrosourea.
Topics: Alkylating Agents; Alkylation; Animals; Binding Sites; Carcinogens; Cell Membrane; DNA; Guanine; Hydrogen Bonding; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Specificity; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Stomach | 1995 |
Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability.
Topics: Alkylating Agents; Animals; Cyclic GMP; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose; Guanine; Insulin; Islets of Langerhans; Methyl Methanesulfonate; Methylnitrosourea; Nitric Oxide; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship | 1995 |
Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase.
Topics: Animals; DNA Adducts; DNA Repair; Guanine; In Vitro Techniques; Liver; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Poly dA-dT; Polydeoxyribonucleotides; Pyridines; Rats | 1996 |
Intrachromosomal probes for mutagenesis by alkylated DNA bases replicated in mammalian cells: a comparison of the mutagenicities of O4-methylthymine and O6-methylguanine in cells with different DNA repair backgrounds.
Topics: Animals; CHO Cells; Cricetinae; DNA; DNA Repair; Genetic Markers; Genetic Vectors; Guanine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Sequence Analysis; Thymine; Transfection | 1996 |
Induction of hprt gene mutations in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O6-methylguanine in bone marrow and not in the spleen.
Topics: Alkylating Agents; Animals; Bone Marrow; Guanine; Hypoxanthine Phosphoribosyltransferase; Lung; Male; Methylation; Mutagenicity Tests; Mutagens; Point Mutation; Rats; Rats, Inbred Lew; Spleen; T-Lymphocytes | 1996 |
O6-methylguanine induces intrachromosomal homologous recombination in human cells.
Topics: Cells, Cultured; Cinnamates; DNA Adducts; Gene Conversion; Guanine; Humans; Hygromycin B; Methylnitronitrosoguanidine; Recombination, Genetic; Thymidine Kinase | 1996 |
Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal
Topics: Alkylating Agents; Animals; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glycoproteins; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Recombination, Genetic; RNA, Messenger; Transcription Factor AP-1; Transfection; Ultraviolet Rays | 1996 |
Processing of O6-methylguanine by mismatch correction in human cell extracts.
Topics: Cell Extracts; DNA Repair; DNA, Neoplasm; Guanine; HeLa Cells; Humans; Tumor Cells, Cultured | 1996 |
Effect of UVM induction on mutation fixation at non-pairing and mispairing DNA lesions.
Topics: Adenine; Bacteriophage M13; Cytosine; DNA, Single-Stranded; DNA, Viral; Escherichia coli; Guanine; Methylnitronitrosoguanidine; Mutagenesis; Mutagens; Transfection; Ultraviolet Rays | 1996 |
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Glial cell-specific differences in repair of O6-methylguanine.
Topics: Alkylating Agents; Animals; Astrocytes; DNA Damage; DNA Repair; Guanine; Methylnitrosourea; Methyltransferases; Microglia; O(6)-Methylguanine-DNA Methyltransferase; Oligodendroglia; Rats; Time Factors | 1996 |
Formation and persistence of N7- and O6-methyl-guanine in DNA of chick embryo brain cells in ovo following administration of N-nitroso-N-methylurea.
Topics: Animals; Brain; Brain Chemistry; Chick Embryo; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Dose-Response Relationship, Drug; Electrochemistry; Guanine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Time Factors | 1996 |
Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA.
Topics: DNA; Glycine; Guanine; Humans; Nitrosamines | 1997 |
Determination of N7- and O6-methylguanine in rat liver DNA after oral exposure to hydrazine by use of immunochemical and electrochemical detection methods.
Topics: Animals; Chromatography, High Pressure Liquid; DNA Adducts; Electrochemistry; Guanine; Hydrazines; Immunochemistry; Liver; Rats; Rats, Wistar | 1997 |
Mechanism of enhancement of esophageal tumorigenesis by 6-phenylhexyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Dimethylnitrosamine; Esophagus; Guanine; Isothiocyanates; Male; Rats; Rats, Inbred F344 | 1997 |
Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents.
Topics: Alkylating Agents; Animals; Cell Division; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Enzyme Inhibitors; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Thioguanine | 1997 |
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; DNA Methylation; Dose-Response Relationship, Drug; Ellagic Acid; Esophageal Neoplasms; Female; Guanine; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase.
Topics: Binding Sites; DNA; DNA Footprinting; Endopeptidases; Enzyme Stability; Escherichia coli; Guanine; Humans; Hydrolysis; Methyltransferases; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotides; Sequence Deletion; Substrate Specificity | 1997 |
Formation and repair of O6-methylguanine in recombination hot spots of plant chromosomes.
Topics: Alkylating Agents; Chromatids; Chromosome Aberrations; Chromosomes; Deoxyribonucleases, Type II Site-Specific; DNA Repair; DNA, Plant; Fabaceae; Guanine; Immunoblotting; Meristem; Methylnitrosourea; Mutagens; Plant Roots; Plants, Medicinal; Recombination, Genetic; Repetitive Sequences, Nucleic Acid | 1997 |
Removal of O6-methylguanine from plant DNA in vivo is accelerated under conditions of clastogenic adaptation.
Topics: Adaptation, Physiological; Alkylating Agents; Chromosome Aberrations; DNA Adducts; DNA Damage; DNA, Plant; Fabaceae; Guanine; Immunoblotting; Meristem; Methylnitrosourea; Mutagens; Plants, Medicinal | 1997 |
Symposium on the significance of low level exposures to DNA adduct inducing chemicals, Department of Health, London, UK, May 1996.
Topics: Adenomatous Polyposis Coli; Animals; Biomarkers; Carcinogens; DNA Adducts; DNA Damage; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay; Epidemiologic Methods; Epidemiological Monitoring; Guanine; Humans; Isotope Labeling; Models, Biological; Neoplasms; Phosphorus Radioisotopes; Risk Factors | 1997 |
Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA replication.
Topics: Cytosine; DNA Replication; Guanine; Hydrogen Bonding; Hydrogen-Ion Concentration; Structure-Activity Relationship; Thymine | 1997 |
Specificity of DNA repair methyltransferases determined by competitive inactivation with oligonucleotide substrates: evidence that Escherichia coli Ada repairs O6-methylguanine and O4-methylthymine with similar efficiency.
Topics: Bacterial Proteins; Binding, Competitive; Cloning, Molecular; DNA Repair; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Gene Expression; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Peptide Fragments; Thymine; Transcription Factors | 1997 |
Effect of intestinal bacteria on formation of azoxymethane-induced aberrant crypt foci in the rat colon.
Topics: Animals; Azoxymethane; Bacteroides fragilis; Bifidobacterium; Body Weight; Clostridium perfringens; Colonic Neoplasms; Culture Media; Drinking; Escherichia coli; Guanine; Injections, Subcutaneous; Intestinal Mucosa; Lactobacillus acidophilus; Male; Rats; Rats, Sprague-Dawley | 1997 |
Klenow fragment-DNA interaction required for the incorporation of nucleotides opposite guanine and O6-methylguanine.
Topics: Antimetabolites; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA Polymerase I; Guanine; Kinetics; Thymine Nucleotides | 1997 |
DNA damage and mutagenesis induced by procarbazine in lambda lacZ transgenic mice: evidence that bone marrow mutations do not arise primarily through miscoding by O6-methylguanine.
Topics: Animals; Antineoplastic Agents; Bone Marrow; DNA Damage; Guanine; Lac Operon; Liver; Male; Mice; Mice, Transgenic; Mutation; Procarbazine | 1997 |
Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models.
Topics: Animals; Apoptosis; Cell Death; CHO Cells; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; DNA Adducts; DNA Methylation; DNA Repair; DNA Replication; Drug Resistance; Guanine; Methylnitronitrosoguanidine; Models, Genetic; Mutagenicity Tests; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange | 1997 |
Reversal of methylation tolerance by transfer of human chromosome 2.
Topics: Centromere; Chromosomes, Human, Pair 2; DNA Methylation; DNA Probes; DNA Repair; Drug Resistance; Gene Transfer Techniques; Guanine; HeLa Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Methylnitrosourea; Microsatellite Repeats; Mutagenesis; Mutagens; Sister Chromatid Exchange | 1997 |
Mutation and formation of methyl- and hydroxylguanine adducts in DNA caused by N-nitrosodimethylamine and N-nitrosodiethylamine with UVA irradiation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Bacterial Proteins; Deoxyguanosine; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Adducts; DNA Repair; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Proteins; Guanine; Methyltransferases; Mutagenesis; Mutagenicity Tests; Oxidation-Reduction; Plasmids; Salmonella typhimurium; Ultraviolet Rays | 1997 |
Implication of localization of human DNA repair enzyme O6-methylguanine-DNA methyltransferase at active transcription sites in transcription-repair coupling of the mutagenic O6-methylguanine lesion.
Topics: Alkylating Agents; Alkylation; Animals; Antibodies, Monoclonal; Binding Sites; Blotting, Western; Cell Cycle; Cell Line; Cell Nucleus; Deoxyribonuclease I; DNA Damage; DNA Repair; Epitope Mapping; Epitopes, B-Lymphocyte; Guanine; HeLa Cells; Humans; Methylnitrosourea; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Rabbits; Transcription, Genetic | 1998 |
Effect of tea on the formation of DNA adducts by azoxymethane.
Topics: Alkylation; Animals; Azoxymethane; Colon; Cytochrome P-450 CYP2E1; DNA; DNA Adducts; DNA Methylation; Guanine; Liver; Male; Rats; Rats, Inbred F344; Tea | 1998 |
Comparison of mutagenesis by O6-methyl- and O6-ethylguanine and O4-methylthymine in Escherichia coli using double-stranded and gapped plasmids.
Topics: DNA Methylation; DNA Repair; Escherichia coli; Guanine; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Thymine | 1998 |
O6-methylguanine and O6-methylguanine-DNA [corrected] methyltransferase activity in tissues of BDF-1 mice treated with antiparasitic drugs.
Topics: Animals; DNA Damage; Guanine; Hycanthone; Intestines; Liver; Male; Mice; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Oxamniquine; Schistosomicides; Trichlorfon; Urinary Bladder | 1998 |
Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells.
Topics: Animals; DNA Methylation; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA Primers; DNA Replication; Guanine; Liver Neoplasms, Experimental; Rats | 1997 |
Initial levels of azoxymethane-induced DNA methyl adducts are not predictive of tumor susceptibility in inbred mice.
Topics: Animals; Azoxymethane; Biotransformation; Carcinogens; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Guanine; Immunoblotting; Male; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Neoplasms, Experimental; Predictive Value of Tests | 1998 |
Chromium(III) decreases the fidelity of human DNA polymerase beta.
Topics: Binding Sites; Chromium; Deoxycytidine Monophosphate; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; DNA Polymerase beta; DNA Replication; DNA, Single-Stranded; Enzyme Activation; Guanine; Humans; Kinetics; Templates, Genetic; Thymine Nucleotides | 1998 |
Possible rare involvement of O6-methylguanine formation as a significant mutational factor in mouse urinary bladder carcinogenesis models.
Topics: Adenosine Deaminase; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Epithelium; Female; Genes, p53; Guanine; Humans; Incidence; Male; Mice; Mice, Inbred C3H; Mice, Transgenic; Mutation; Neoplasm Invasiveness; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Urinary Bladder; Urinary Bladder Neoplasms | 1998 |
Critical steps in alkylation-induced aberration formation.
Topics: Alkylating Agents; Animals; Cell Cycle; Chromosome Aberrations; DNA Damage; DNA Repair; DNA Replication; Fibroblasts; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Nucleic Acid Synthesis Inhibitors; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Sister Chromatid Exchange | 1998 |
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Dacarbazine; DNA Glycosylases; Erythrocytes; Ethylnitrosourea; Female; Fibroblasts; Guanine; Hypoxanthine Phosphoribosyltransferase; Leukocyte Count; Liver; Male; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mutagens; Mutation; N-Glycosyl Hydrolases; Temozolomide | 1998 |
The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA injury and the fixation of the DNA injury in mouse lungs.
Topics: Animals; Carcinogens; DNA Damage; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Rabbits; Specific Pathogen-Free Organisms; Vitamin E | 1998 |
Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; DNA Adducts; DNA Repair; Female; Guanine; Humans; Hydroxyurea; Hypoxanthine Phosphoribosyltransferase; Leukocytes; Male; Melanoma; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1996 |
The sensitization of cells treated with O6-methylguanine to alkylation damage is affected by the number of O6-methylguanine-DNA methyltransferase molecules escaped from inactivation.
Topics: Animals; Catalytic Domain; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Guanine; Humans; Mutagens; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins | 1998 |
Nickel(II) inhibits the repair of O6-methylguanine in mammalian cells.
Topics: Animals; Blotting, Western; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; DNA Repair; Female; Guanine; Humans; Methylnitrosourea; Nickel; O(6)-Methylguanine-DNA Methyltransferase; Transfection | 1998 |
Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Amino Acid Substitution; Codon; DNA Damage; DNA Repair; Escherichia coli; Guanine; Humans; Methylnitronitrosoguanidine; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Recombinant Fusion Proteins; Thymidine | 1999 |
O6-Alkylguanine-DNA alkyltransferase: influence on susceptibility to the genetic effects of alkylating agents.
Topics: Alkylating Agents; DNA; DNA Repair; Guanine; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase | 1998 |
The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Topics: Animals; Chromatography, High Pressure Liquid; Cotinine; DNA Adducts; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanine; Liver; Lung; Mice; Mutagens; Nitrosamines; Tobacco Smoke Pollution | 1999 |
Methyl bromide causes DNA methylation in rats and mice but fails to induce somatic mutations in lambda lacZ transgenic mice.
Topics: Animals; DNA Adducts; DNA Methylation; Dose-Response Relationship, Drug; Guanine; Hydrocarbons, Brominated; Lac Operon; Male; Mice; Mice, Transgenic; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley | 1999 |
Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Repair; DNA, Complementary; Drosophila melanogaster; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thymine; Transcription Factors | 1999 |
Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15.
Topics: Base Pair Mismatch; Base Sequence; Colonic Neoplasms; DNA Primers; DNA Repair; DNA-Binding Proteins; DNA, Complementary; G2 Phase; Guanine; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Microsatellite Repeats; Mutation; Phenotype; Transfection; Tumor Cells, Cultured | 1999 |
Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase.
Topics: Binding Sites; DNA Repair; Guanine; Humans; Kinetics; Mutagenesis; Nucleic Acid Heteroduplexes; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Protein Binding; Structure-Activity Relationship; Substrate Specificity | 1999 |
Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Brain Neoplasms; DNA Modification Methylases; Drug Resistance, Neoplasm; Female; Glioma; Guanine; Humans; Male; Middle Aged; Nitroso Compounds; Tumor Cells, Cultured | 1999 |
DNA methylation by tert-butyl hydroperoxide-iron (II): a role for the transition metal ion in the production of DNA base adducts.
Topics: Adenine; Animals; Cattle; Chelating Agents; Copper; DNA Adducts; DNA Methylation; Electron Spin Resonance Spectroscopy; Free Radicals; Guanine; Iron; Molecular Structure; tert-Butylhydroperoxide | 1999 |
Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzamides; Dacarbazine; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Jurkat Cells; Leukemia; N-Glycosyl Hydrolases; Poly(ADP-ribose) Polymerase Inhibitors; RNA, Messenger; Temozolomide; Transcription, Genetic; Triazenes | 1999 |
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Codon; DNA Adducts; DNA Damage; DNA Methylation; Genes, ras; Guanine; Humans; Lac Operon; Lymphoma; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Organ Specificity; Point Mutation; Spleen; Thymus Gland; Thymus Neoplasms; Transgenes | 1999 |
Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines.
Topics: Antineoplastic Agents, Alkylating; Base Pair Mismatch; DNA Repair; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Methyl Methanesulfonate; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Sequence Analysis; Tumor Cells, Cultured | 1999 |
The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents.
Topics: Alkylating Agents; Animals; Base Pairing; CHO Cells; Cricetinae; DNA Mutational Analysis; DNA Primers; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Folic Acid Deficiency; Guanine; Hypoxanthine Phosphoribosyltransferase; Mutagens; Mutation; Polymerase Chain Reaction; Thioguanine | 1999 |
The cytotoxicity of DNA carboxymethylation and methylation by the model carboxymethylating agent azaserine in human cells.
Topics: Adenine; Alkylating Agents; Azaserine; Azo Compounds; Burkitt Lymphoma; Carcinogens; DNA Adducts; DNA Damage; DNA Methylation; Drug Resistance; Enzyme Induction; Genetic Complementation Test; Glycine; Guanine; Humans; Lymphocytes; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured; Xeroderma Pigmentosum | 1999 |
Context-dependent mutagenesis by DNA lesions.
Topics: DNA Mutational Analysis; DNA Repair; DNA, Single-Stranded; DNA, Viral; Electroporation; Escherichia coli; Guanine; Mutagenesis; Point Mutation | 1999 |
O(6)-methylguanine DNA adducts associated with occupational nitrosamine exposure.
Topics: DNA Adducts; Genotype; Guanine; Humans; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Occupational Exposure; Rubber | 2000 |
Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Guanine; Humans; Male; Melanoma, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous | 2000 |
Induction of somatic mutations but not methylated DNA adducts in lambdalacZ transgenic mice by dichlorvos.
Topics: Animals; Dichlorvos; DNA Methylation; Guanine; Insecticides; Lac Operon; Mice; Mice, Transgenic; Mutation | 1999 |
Ubiquitous presence of O6-methylguanine in human peripheral and cord blood DNA.
Topics: Adult; DNA; DNA Adducts; DNA Damage; Environmental Exposure; Female; Fetal Blood; Guanine; Humans; Leukocytes; Pregnancy | 2000 |
Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase.
Topics: Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Dacarbazine; DNA Methylation; DNA Mutational Analysis; Enzyme Induction; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Liver Extracts; Male; Methylnitrosourea; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Rats, Sprague-Dawley | 2000 |
Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions.
Topics: Adenine; Alkylation; Apurinic Acid; Base Sequence; DNA; DNA Adducts; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; Guanine; Humans; Isoenzymes; Mutation; Oligonucleotides; Oxidation-Reduction; Plasmids; Sensitivity and Specificity | 2000 |
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Carcinogens; DNA; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mutagens; Mutation; Rats | 2000 |
Preparation of a methylated DNA standard, and its stability on storage.
Topics: Drug Stability; Guanine | 2000 |
Formation and persistence of O(6)-methylguanine in the mouse colon following treatment with 1,2-dimethylhydrazine as measured by an O(6)-alkylguanine-DNA alkyltransferase inactivation assay.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; DNA; DNA Methylation; Female; Guanine; Mice; O(6)-Methylguanine-DNA Methyltransferase; Reproducibility of Results | 2000 |
The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica (wasabi) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-buatnone-induced lung tumorigenesis in mice.
Topics: Animals; Body Weight; Carcinogens; Female; Guanine; Immunoblotting; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Ornithine Decarboxylase; Plant Extracts; Proliferating Cell Nuclear Antigen; Spices | 2000 |
Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.
Topics: DNA Damage; DNA Repair; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Lac Operon; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Point Mutation; Substrate Specificity; Thymine | 2000 |
Induction of apoptosis and inhibition of signalling pathways by alkylated purines.
Topics: Adenine; Alkylation; Androstadienes; Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Line; Cricetinae; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Fibroblasts; G1 Phase; Genes, p53; Guanine; MAP Kinase Signaling System; Mutation; Phosphorylation; Purines; Resting Phase, Cell Cycle; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination.
Topics: Alleles; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Codon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Genes, p53; Guanine; Homozygote; Humans; Loss of Heterozygosity; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Transcriptional Activation | 2000 |
Dietary fish oil reduces O6-methylguanine DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Apoptosis; Colonic Neoplasms; DNA Adducts; DNA Damage; DNA Repair; Fish Oils; Guanine; Intestinal Mucosa; Likelihood Functions; Male; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; tRNA Methyltransferases | 2000 |
Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Alkylating Agents; Base Pair Mismatch; Carrier Proteins; Cell Line; Cell Nucleus; Cytoplasm; DNA; DNA Damage; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Gene Expression Regulation; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Proto-Oncogene Proteins; RNA Stability; RNA, Messenger | 2000 |
Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Pair Mismatch; Carcinogens; Cell Line; DNA; DNA Adducts; DNA Damage; DNA Repair; Fibroblasts; Guanine; Humans; Methylnitronitrosoguanidine; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombination, Genetic | 2000 |
Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.
Topics: Alkylating Agents; Base Sequence; Cytosine; DNA Polymerase III; DNA Polymerase iota; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Fungal Proteins; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutation; Thymidine | 2000 |
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; CHO Cells; Cricetinae; Cytochrome c Group; DNA Damage; Enzyme Activation; Fas Ligand Protein; fas Receptor; Guanine; Membrane Glycoproteins; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Phosphorylation; Protease Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2 | 2000 |
Coexposure to ethanol with N-nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone during lactation of rats: marked increase in O(6)-methylguanine-DNA adducts in maternal mammary gland and in suckling lung and kidney.
Topics: Animals; Animals, Newborn; Animals, Suckling; Carcinogens; DNA Adducts; Ethanol; Female; Guanine; Kidney; Lactation; Lung; Mammary Glands, Animal; Nitrosamines; Nitroso Compounds; Rats; Rats, Sprague-Dawley | 2000 |
Role of cytochrome P450 in DNA damage produced by treatment of colon cells with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Benz(a)Anthracenes; Carcinogens; Colon; Cytochrome P-450 Enzyme System; DNA; DNA Damage; Enzyme Activators; Glutathione; Guanine; Humans; Hypnotics and Sedatives; Methyltransferases; Phenobarbital; Pyrazoles | 2001 |
Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.
Topics: Alkylating Agents; Animals; CHO Cells; Cricetinae; DNA; DNA Topoisomerases, Type I; Guanine; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Transfection | 2001 |
Evidence for the involvement of lesions other than O6-alkylguanine in mammalian cell mutagenesis.
Topics: Adenine; Alkylating Agents; Animals; Carcinogens; Cricetinae; DNA; DNA Damage; Drug Resistance; Guanine; Hypoxanthine Phosphoribosyltransferase; Methyl Methanesulfonate; Methylnitrosourea; Mutagenesis; Mutagens; Sulfuric Acid Esters; Thioguanine | 1980 |
The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions.
Topics: Alkylating Agents; Base Pair Mismatch; Base Sequence; DNA Repair; DNA-Directed DNA Polymerase; Exodeoxyribonucleases; Guanine; Methylnitrosourea; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Substrate Cycling; Substrate Specificity; Templates, Genetic; Viral Proteins | 2001 |
Initiation of strand incision at G:T and O(6)-methylguanine:T base mismatches in DNA by human cell extracts.
Topics: Adenosine Triphosphate; Base Pair Mismatch; Base Sequence; Cell Extracts; Cell-Free System; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Repair; Dose-Response Relationship, Drug; Endodeoxyribonucleases; Guanine; HT29 Cells; Humans; Mutation; Nucleotides; Substrate Specificity; Thymine; Tumor Cells, Cultured | 2001 |
Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcinogens; Cell Division; Cell Transformation, Neoplastic; DNA Mutational Analysis; Female; Guanine; Humans; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Knockout; Mice, Transgenic; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Single-Stranded Conformational; RNA, Messenger; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 2001 |
Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are associated with GSTT1 genotype and O(6)-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype.
Topics: Adenosine Triphosphatases; Aged; Alkylation; Colorectal Neoplasms; Cross-Sectional Studies; Cytochrome P-450 CYP2D6; DNA Repair; DNA, Neoplasm; Female; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Guanine; Humans; Male; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins p21(ras) | 2001 |
Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.
Topics: Base Pair Mismatch; Colonic Neoplasms; Escherichia coli; Genetic Vectors; Guanine; Humans; Kidney; Lac Operon; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Transfection | 2001 |
Accuracy of lesion bypass by yeast and human DNA polymerase eta.
Topics: DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Ligases; Saccharomyces cerevisiae; Thymine; Ubiquitin-Conjugating Enzymes; Ultraviolet Rays | 2001 |
Ethanol enhances the formation of endogenously and exogenously derived adducts in rat hepatic DNA.
Topics: Alkylating Agents; Animals; Binding, Competitive; Blotting, Western; Carcinogens; Central Nervous System Depressants; Chromatography, Thin Layer; Cytochrome P-450 CYP2E1; Deoxyadenosines; Deoxycytidine; DNA Adducts; DNA Damage; Ethanol; Guanine; Immunohistochemistry; Liver; Male; Mice; Mutagens; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Wistar; Time Factors | 2001 |
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2001 |
High-performance liquid chromatographic method with electrochemical detection for the analysis of O6-methylguanine.
Topics: Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Colonic Neoplasms; DNA Damage; Electrochemistry; Guanine; Humans; Sensitivity and Specificity; Tumor Cells, Cultured | 2001 |
Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.
Topics: Animals; Carcinogens; Chemoprevention; Diet; Dimethylnitrosamine; DNA Adducts; Ellagic Acid; Esophageal Neoplasms; Freeze Drying; Fruit; Guanine; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 2001 |
Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins.
Topics: Animals; Base Pair Mismatch; Cell Survival; CHO Cells; Cricetinae; DNA Repair; Guanine; O(6)-Methylguanine-DNA Methyltransferase; Thymine | 2001 |
The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Drug Interactions; Female; Guanine; Hydroxylation; Injections, Intraperitoneal; Liver; Lung; Mice; Mice, Inbred Strains; Nitrosamines; Tobacco Smoke Pollution | 2001 |
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
Topics: Animals; Azoxymethane; Biotransformation; Carcinogens; Colon; Cytochrome P-450 CYP2E1; DNA; DNA Methylation; Female; Guanine; Liver; Male; Methylazoxymethanol Acetate; Mice; Precancerous Conditions | 2001 |
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine.
Topics: Antineoplastic Agents; Carcinogens; Deoxyribonucleotides; DNA Primers; DNA-Directed DNA Polymerase; Guanine; HIV Reverse Transcriptase; Kinetics; Substrate Specificity; Templates, Genetic | 2002 |
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes.
Topics: Carcinogens; Deoxyribonucleotides; DNA Adducts; DNA Replication; DNA-Directed DNA Polymerase; Guanine; HIV Reverse Transcriptase; Kinetics; Models, Theoretical; Oligodeoxyribonucleotides; Recombinant Proteins; Substrate Specificity | 2002 |
Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats.
Topics: Animals; Antimutagenic Agents; Antineoplastic Agents; Azoxymethane; Colon; Colonic Neoplasms; DNA Methylation; Guanine; Intestinal Mucosa; Magnoliopsida; Male; Mutagenicity Tests; Mutagens; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred F344; Salmonella typhimurium | 2002 |
Role of human DNA polymerase kappa as an extender in translesion synthesis.
Topics: DNA Damage; DNA Polymerase III; DNA Primers; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Kinetics; Nucleotides; Pyrimidine Dimers; Substrate Specificity | 2002 |
[Determination of O6-methylguanine by high performance capillary zone electrophoresis].
Topics: DNA Adducts; Electrophoresis, Capillary; Guanine; Humans; Mutagens | 2000 |
Yeast DNA polymerase zeta is an efficient extender of primer ends opposite from 7,8-dihydro-8-Oxoguanine and O6-methylguanine.
Topics: Base Sequence; DNA Primers; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Kinetics; Molecular Sequence Data; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity | 2003 |
K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts.
Topics: Base Sequence; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Genes, ras; Guanine; Humans; Nitrosamines; Smoking; Time Factors | 2003 |
Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Deuterium; DNA; DNA Adducts; Dose-Response Relationship, Drug; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes; Mixed Function Oxygenases; Molecular Structure; Nitrosamines; Stereoisomerism; Structure-Activity Relationship | 2003 |
The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells.
Topics: Cell Survival; Cells, Cultured; DNA Mutational Analysis; Exons; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Methylnitronitrosoguanidine; Mutation; O(6)-Methylguanine-DNA Methyltransferase; T-Lymphocytes | 2003 |
O6-alkylguanine-DNA alkyltransferases repair O6-methylguanine in DNA with Michaelis-Menten-like kinetics.
Topics: Chromatography, High Pressure Liquid; DNA Damage; DNA Repair; DNA Repair Enzymes; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Guanine; Kinetics; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Phosphorus Radioisotopes; Substrate Specificity; Temperature; Time Factors | 2003 |
The syntheses of tricyclic analogues of O6-methylguanine.
Topics: Binding Sites; Cyclization; Guanine; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase | 2003 |
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Division; Dacarbazine; DNA Damage; DNA Replication; fas Receptor; Gamma Rays; Gene Expression Regulation; Guanine; Humans; Lymphocytes; Methylnitronitrosoguanidine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Temozolomide; Tumor Suppressor Protein p53 | 2004 |
Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Chromosome Aberrations; DNA-Binding Proteins; Guanine; Mice; Mice, Knockout; Protein Serine-Threonine Kinases; Sister Chromatid Exchange; Tumor Suppressor Proteins | 2004 |
Synthesis and characterization of bifunctional probes for the specific labeling of fusion proteins.
Topics: Cloning, Molecular; Glutathione Transferase; Guanine; Molecular Probes; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins | 2004 |
Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.
Topics: Age Factors; Animals; Base Pair Mismatch; DNA-Binding Proteins; Female; Guanine; Lac Operon; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transgenes | 2004 |
Proofreading activity of Pfu thermostable DNA polymerase on a 6-O-methylguanine-containing template monitored by ESI-FTICR mass spectrometry.
Topics: DNA-Directed DNA Polymerase; Guanine; Mass Spectrometry; Oligonucleotides; Polymerase Chain Reaction; Pyrococcus furiosus; Spectroscopy, Fourier Transform Infrared | 2004 |
Quantitation of the adaptive response to alkylating agents.
Topics: Adaptation, Physiological; Alkylation; Chloramphenicol; DNA Damage; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Guanine; Methylnitronitrosoguanidine; Mutagens; Temperature | 1979 |
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.
Topics: Adaptation, Physiological; Alkylation; DNA Damage; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Guanine; Methylnitronitrosoguanidine; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors | 1979 |
Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats.
Topics: Animals; Anticarcinogenic Agents; Antimetabolites; Apoptosis; Azoxymethane; Bromodeoxyuridine; Carcinogens; Cell Proliferation; Centella; Colon; Diet; DNA Methylation; Guanine; Intestinal Mucosa; Intestinal Neoplasms; Liver; Male; Plant Extracts; Rats; Rats, Inbred F344 | 2004 |
Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis.
Topics: Amino Acid Substitution; Base Pair Mismatch; DNA Adducts; DNA Damage; DNA Polymerase I; DNA Primers; DNA Repair; DNA, Bacterial; Exonucleases; Guanine; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Substrate Specificity; Templates, Genetic | 2005 |
Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli.
Topics: Alkyl and Aryl Transferases; DNA; DNA Glycosylases; Endonucleases; Escherichia coli; Escherichia coli Proteins; Guanine; Methylnitronitrosoguanidine; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 2005 |
PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells.
Topics: Apoptosis; Base Pair Mismatch; Cell Line, Tumor; Chromatin; DNA; DNA Damage; DNA Repair Enzymes; DNA Replication; DNA-Binding Proteins; Guanine; HeLa Cells; Humans; Kinetics; Methylnitrosourea; Mutation; MutL Proteins; MutS Homolog 2 Protein; Neoplasm Proteins; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins | 2005 |
Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.
Topics: Animals; Antigens, Differentiation; Antineoplastic Agents, Alkylating; Cell Cycle Proteins; Cell Line, Tumor; Comet Assay; Dacarbazine; DNA Damage; DNA Repair; Drug Synergism; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Oncolytic Viruses; Plasmids; Protein Phosphatase 1; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotide Reductases; RNA, Small Interfering; Simplexvirus; Temozolomide; Transcription, Genetic; Transfection; Transplantation, Heterologous | 2006 |
Simultaneous quantitation of 7-methyl- and O6-methylguanine adducts in DNA by liquid chromatography-positive electrospray tandem mass spectrometry.
Topics: Alkylation; Animals; Chromatography, Liquid; DNA; DNA Adducts; Guanine; Reference Standards; Reproducibility of Results; Salmon; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2006 |
The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.
Topics: Crystallography, X-Ray; Guanine; Humans; Hydrogen-Ion Concentration; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Pyrroles; Substrate Specificity; Thioguanine | 2006 |
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts.
Topics: Adaptor Proteins, Signal Transducing; Animals; Ataxia Telangiectasia Mutated Proteins; Base Pair Mismatch; Base Sequence; Carrier Proteins; Cell Cycle Proteins; Cell Line; DNA; DNA Adducts; DNA Damage; DNA Repair; DNA-Binding Proteins; Enzyme Activation; Exodeoxyribonucleases; Guanine; HeLa Cells; Humans; Mice; MutS DNA Mismatch-Binding Protein; Nuclear Proteins; Phosphoproteins; Protein Serine-Threonine Kinases; S Phase; Signal Transduction | 2006 |
Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts.
Topics: Adenosine Triphosphate; Base Pair Mismatch; Base Sequence; Cell Nucleus; DNA Methylation; DNA Repair; DNA Repair Enzymes; Guanine; HeLa Cells; Humans; Molecular Sequence Data; MutL Proteins; MutS DNA Mismatch-Binding Protein; Neoplasm Proteins; Nucleic Acid Heteroduplexes | 2006 |
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Caspases; Cell Cycle; Cell Proliferation; Dacarbazine; DNA Breaks, Double-Stranded; DNA Damage; Fas Ligand Protein; Fas-Associated Death Domain Protein; Flow Cytometry; Glioma; Guanine; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2007 |
DNA stability in the gas versus solution phases: a systematic study of thirty-one duplexes with varying length, sequence, and charge level.
Topics: Chemical Phenomena; Chemistry, Physical; DNA; DNA Replication; Gases; Guanine; Mutagens; Solutions; Spectrometry, Mass, Electrospray Ionization; Temperature | 2006 |
Role of hoogsteen edge hydrogen bonding at template purines in nucleotide incorporation by human DNA polymerase iota.
Topics: Base Pairing; Cytosine; DNA Damage; DNA Polymerase iota; DNA Primers; DNA-Directed DNA Polymerase; Guanine; Humans; Hydrogen Bonding; Kinetics; Purines; Templates, Genetic; Thymine | 2006 |
Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred.
Topics: Binding Sites; Catalysis; Crystallography, X-Ray; Cytosine; DNA Polymerase beta; Guanine; Kinetics; Models, Chemical; Protein Structure, Tertiary; Sulfolobus solfataricus | 2007 |
The structural basis for the mutagenicity of O(6)-methyl-guanine lesions.
Topics: Binding Sites; Crystallography, X-Ray; DNA; DNA-Directed DNA Polymerase; Guanine; Kinetics; Models, Molecular; Mutation; Protein Structure, Tertiary | 2006 |
Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair.
Topics: Animals; Apoptosis; Base Sequence; Cell Differentiation; DNA Adducts; DNA Damage; DNA Methylation; DNA Mismatch Repair; DNA-Binding Proteins; DNA, Complementary; E2F1 Transcription Factor; Embryonic Stem Cells; Fibroblasts; Guanine; Methylnitronitrosoguanidine; Mice; Models, Biological; MutS Homolog 2 Protein; O(6)-Methylguanine-DNA Methyltransferase; Pluripotent Stem Cells; Swiss 3T3 Cells | 2007 |
Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; DNA Damage; Guanine; Humans; Luciferases; Microscopy, Fluorescence; NF-kappa B; Protein Binding; Subcellular Fractions; Temozolomide; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor RelA | 2007 |
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Topics: Animals; Carcinogens; Doxycycline; Female; Guanine; Inbreeding; Liver; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Transgenic; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Pyridines | 2007 |
Mismatch repair proteins collaborate with methyltransferases in the repair of O(6)-methylguanine.
Topics: DNA Mismatch Repair; DNA-Binding Proteins; Electroporation; Escherichia coli; Escherichia coli Proteins; Guanine; Methyltransferases; Oligonucleotides; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 2008 |
The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.
Topics: Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Guanine; Humans; In Vitro Techniques; Kinetics; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase | 2007 |
Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Colon; Colonic Neoplasms; DNA Adducts; Down-Regulation; Fluorescent Antibody Technique; Guanine; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53; Vanadium | 2008 |
A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT.
Topics: Binding Sites; Computer Simulation; DNA; DNA Damage; Guanine; Humans; Kinetics; Nucleic Acid Conformation; Nucleotides; O(6)-Methylguanine-DNA Methyltransferase; Protein Structure, Secondary; Static Electricity; Thermodynamics; Tyrosine | 2008 |
Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry.
Topics: Adenine; Animals; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Guanine; Male; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfuric Acid Esters; Testis | 2008 |
Effect of O6-methylguanine on the stability of G-quadruplex DNA.
Topics: Circular Dichroism; Computer Simulation; DNA; DNA Methylation; G-Quadruplexes; Guanine; Oligonucleotides | 2008 |
An O6-methylguanine-DNA methyltransferase-like protein from Thermus thermophilus interacts with a nucleotide excision repair protein.
Topics: Amino Acid Sequence; Bacterial Proteins; DNA; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Guanine; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Sequence Homology, Amino Acid; Thermus thermophilus | 2008 |
[Methylnitrosourea as challenge mutagen in assessment of the DNA mismatch repair (MMR) activity: association with some types of cancer].
Topics: Apoptosis; Chromosome Aberrations; Comet Assay; DNA Mismatch Repair; DNA, Neoplasm; Female; Genital Neoplasms, Female; Guanine; HeLa Cells; Humans; In Vitro Techniques; Lymphocytes; Methylnitrosourea; Microsatellite Instability; Mutagens | 2008 |
Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment.
Topics: Animals; Animals, Genetically Modified; Carcinogens; Dimethylnitrosamine; DNA; DNA Adducts; Dose-Response Relationship, Drug; Guanine; Immunohistochemistry; Liver; Male; Models, Biological; Mutagenicity Tests; Mutation; Oryzias; Random Allocation; Rats; Rats, Inbred F344; Rats, Transgenic; Risk Assessment; Water Supply | 2009 |
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Cell Nucleus; Cell Proliferation; Cell Survival; Cycloheximide; Dacarbazine; Drug Resistance, Neoplasm; Enzyme Stability; Gene Expression Regulation, Neoplastic; Glioma; Green Fluorescent Proteins; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2009 |
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.
Topics: Animals; Apoptosis; BRCA2 Protein; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; Dacarbazine; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Down-Regulation; Fluorescent Antibody Technique; Guanine; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Sister Chromatid Exchange; Temozolomide; Transfection | 2009 |
Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase.
Topics: DNA; DNA-Directed RNA Polymerases; Guanine; HeLa Cells; Humans; Hydrogen Bonding; Models, Molecular; Nucleotides; RNA Polymerase II; Templates, Genetic; Transcription, Genetic; Viral Proteins; Yeasts | 2008 |
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.
Topics: Alkylating Agents; Amino Acid Sequence; Animals; BRCA2 Protein; DNA Repair; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Mice; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase | 2008 |
O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo.
Topics: Alkylation; Animals; Apoptosis; Base Pair Mismatch; Bone Marrow Cells; Cell Proliferation; DNA-Binding Proteins; Exodeoxyribonucleases; Fibroblasts; Guanine; Mice; Mice, Inbred C57BL; Mice, Knockout; O(6)-Methylguanine-DNA Methyltransferase; Spleen; Thymus Gland | 2009 |
A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Apoptosis; Base Pair Mismatch; Caspase 3; DNA; DNA Modification Methylases; DNA Repair Enzymes; Etoposide; Fibroblasts; Gene Expression Regulation; Guanine; Humans; Lung; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Knockout; Mutagenesis; Mutation; MutL Protein Homolog 1; Nuclear Proteins; RNA, Small Interfering; Tumor Suppressor Proteins; Ultraviolet Rays | 2009 |
Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Guanine; Liver; Lung; Lung Neoplasms; Nicotiana; Nitrosamines; Prohibitins; Rats; Rats, Inbred F344 | 2009 |
A quantum chemical study of repair of O6-methylguanine to guanine by tyrosine: evaluation of the winged helix-turn-helix model.
Topics: Guanine; Models, Molecular; Nucleic Acid Conformation; Quantum Theory; Thermodynamics; Tyrosine | 2009 |
Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Topics: Alkyl and Aryl Transferases; Alkylation; Binding Sites; Crystallography, X-Ray; DNA; DNA Damage; DNA Repair; Guanine; Humans; Models, Molecular; Protein Binding; Protein Conformation | 2009 |
Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides.
Topics: Alkyl and Aryl Transferases; Chromatography, High Pressure Liquid; Circular Dichroism; Codon; Cytosine; Dinucleoside Phosphates; DNA Methylation; DNA Repair; Electrophoretic Mobility Shift Assay; Genes, p53; Guanine; Humans; Protein Binding; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Ultraviolet Rays | 2009 |
Gas-phase thermochemical properties of the damaged base O(6)-methylguanine versus adenine and guanine.
Topics: Adenine; Computer Simulation; Gases; Guanine; Kinetics; Models, Chemical; Thermodynamics | 2009 |
Repair of O6-methylguanine to guanine by cysteine in the absence and presence of histidine and by cysteine thiolate anion: a quantum chemical study.
Topics: Cysteine; DNA Repair; Guanine; Histidine; Models, Molecular; Molecular Conformation; Quantum Theory; Stereoisomerism; Sulfhydryl Compounds; Thermodynamics | 2009 |
Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.
Topics: Cell Division; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Mismatch Repair; Drug Resistance, Neoplasm; Enzyme Activation; G2 Phase; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Radiation Dosage; Radiation Tolerance; Temozolomide | 2009 |
Acquired resistance to 6-thioguanine in melanoma cells involves the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT).
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; DNA Methylation; Dose-Response Relationship, Drug; Guanine; Humans; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Thioguanine | 2010 |
Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; CHO Cells; Cricetinae; Cricetulus; DNA Breaks, Double-Stranded; DNA Replication; Flow Cytometry; Fluoresceins; Guanine; Methylnitronitrosoguanidine; Microscopy, Fluorescence; O(6)-Methylguanine-DNA Methyltransferase; Succinimides | 2010 |
Inhibitory effects of high temperature- and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Cytochrome P-450 CYP2E1; DNA Adducts; Garlic; Guanine; Hot Temperature; Liver; Male; Mucin-2; Phytotherapy; Plant Extracts; Precancerous Conditions; Pressure; Rats; Rats, Inbred F344; Rectum | 2009 |
O(6)-methylguanine in DNA: bad penny?
Topics: Antineoplastic Agents; DNA; DNA Damage; DNA Mismatch Repair; DNA Replication; Guanine; Humans; Models, Biological; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase | 2010 |
RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; DNA Damage; DNA Repair; DNA-Binding Proteins; Embryo, Mammalian; Fibroblasts; G2 Phase; Guanine; Methylnitronitrosoguanidine; Mice; MutL Protein Homolog 1; Nuclear Proteins; Rad51 Recombinase | 2010 |
Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein.
Topics: Alkyl and Aryl Transferases; Amino Acid Substitution; DNA; DNA Repair; Guanine; Humans; Mutation, Missense; Protein Folding; Vibrio parahaemolyticus | 2010 |
Interaction of murine dnmt3a with DNA containing o6-methylguanine.
Topics: Animals; Base Sequence; Catalytic Domain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Guanine; Kinetics; Mice | 2010 |
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Guanine; Humans; Hydrazines; Mice; O(6)-Methylguanine-DNA Methyltransferase; Sulfonamides; Temozolomide | 2010 |
O6-methylguanine induces altered proteins at the level of transcription in human cells.
Topics: DNA Replication; Fluorescent Dyes; Guanine; HEK293 Cells; Humans; Luminescent Proteins; Mutagenesis; Plasmids; Red Fluorescent Protein; Transcription, Genetic | 2010 |
Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Caspase 7; Cell Cycle Proteins; Cell Line, Transformed; Cell Line, Tumor; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Fibroblasts; Guanine; Homozygote; Humans; Melanoma; Methylnitronitrosoguanidine; Mutagens; Mutation; Necrosis; Nijmegen Breakage Syndrome; Nuclear Proteins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Temozolomide; Uveal Neoplasms | 2010 |
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mechanistic Target of Rapamycin Complex 1; Methylnitronitrosoguanidine; Multiprotein Complexes; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2010 |
Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Dacarbazine; Female; Guanine; Humans; Irinotecan; Mice; Mice, Nude; Neuroblastoma; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Xenograft Model Antitumor Assays | 2010 |
Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.
Topics: Bacterial Proteins; Base Pairing; Catalytic Domain; Deoxycytosine Nucleotides; DNA; DNA Polymerase beta; DNA Polymerase I; DNA Polymerase iota; DNA-Directed DNA Polymerase; Geobacillus stearothermophilus; Guanine; Humans; Hydrogen Bonding; Kinetics; Structure-Activity Relationship; Sulfolobus; Thymine Nucleotides | 2010 |
Role of alkyltransferase-like (ATL) protein in repair of methylated DNA lesions in Thermus thermophilus.
Topics: Alkyl and Aryl Transferases; DNA Damage; DNA Methylation; DNA Repair; Genetic Vectors; Guanine; Methylnitronitrosoguanidine; Mutagens; Mutation; Restriction Mapping; Thermus thermophilus | 2011 |
Development and validation of a new, sensitive immunochemical assay for O⁶-methylguanine in DNA and its application in a population study.
Topics: Animals; Blood Buffy Coat; DNA; Enzyme-Linked Immunosorbent Assay; Female; Fetal Blood; Guanine; HeLa Cells; Humans; Pregnancy; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity | 2011 |
Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O⁶-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Colon; Colonic Neoplasms; DNA Adducts; Garlic; Guanine; Male; Mucins; Precancerous Conditions; Rats; Rats, Inbred F344; Reactive Oxygen Species; Rectum | 2010 |
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; DNA-Activated Protein Kinase; Guanine; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Immunohistochemistry; Immunoprecipitation; Lung; Lung Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Mutagenicity associated with O6-methylguanine-DNA damage and mechanism of nucleotide flipping by AGT during repair.
Topics: Base Pairing; DNA; DNA Damage; DNA Repair; Guanine; Models, Molecular; Mutation; Nucleotides; O(6)-Methylguanine-DNA Methyltransferase; Thermodynamics | 2011 |
Exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of O(6)-methylguanine.
Topics: Bacteriophage T4; Base Pair Mismatch; Base Pairing; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Viral Proteins | 2011 |
Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Adenoma; Animals; Carcinogens; Cells, Cultured; Drinking Water; Female; Guanine; Humans; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nicotine; Nitrosamines | 2011 |
Simultaneous quantification of methylated purines in DNA by isotope dilution LC-MS/MS coupled with automated solid-phase extraction.
Topics: Animals; Cattle; Chromatography, Liquid; DNA; DNA Methylation; Guanine; Indicator Dilution Techniques; Isotopes; Purines; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2012 |
Temozolomide: mechanisms of action, repair and resistance.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Central Nervous System Neoplasms; Dacarbazine; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-(Apurinic or Apyrimidinic Site) Lyase; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide; Tumor Suppressor Proteins | 2012 |
Malignant progression in O6-methylguanine-DNA methyltransferase-deficient esophageal cancer cells is associated with Ezrin protein.
Topics: Animals; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; CHO Cells; Cricetinae; Cytoskeletal Proteins; Electrophoresis, Gel, Two-Dimensional; Esophageal Neoplasms; Esophagus; Fluorescent Antibody Technique; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Real-Time Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transfection | 2012 |
Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.
Topics: Animals; Antioxidants; Ascorbic Acid; Blotting, Western; Carcinogens, Environmental; Cell Cycle; Cell Death; Cells, Cultured; Chromatography, High Pressure Liquid; Chromium; Cricetinae; Cricetulus; DNA Adducts; DNA Damage; DNA Repair; DNA-Binding Proteins; Fibroblasts; Glutathione; Guanine; Humans; Lung; Micronucleus Tests; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; RNA, Small Interfering; X-ray Repair Cross Complementing Protein 1 | 2012 |
The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects.
Topics: Adenine; Alkylating Agents; Alkylation; Carcinogens; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Methylation; Methylnitrosourea | 1980 |
The effects of a single dose of dimethylnitrosamine in the Chinese hamster and the persistence of DNA alkylation products in selected tissues.
Topics: Alkylation; Animals; Cricetinae; Cricetulus; Dimethylnitrosamine; DNA; Drinking Water; Guanine; Kidney; Liver; Liver Neoplasms, Experimental; Lung; Male; Organ Specificity | 1980 |
Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine.
Topics: Alkylating Agents; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA Mismatch Repair; DNA-Directed DNA Polymerase; Guanine; HeLa Cells; Humans; Immunoblotting; Methylnitrosourea; Mitosis; O(6)-Methylguanine-DNA Methyltransferase; Proliferating Cell Nuclear Antigen; Rad51 Recombinase; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sister Chromatid Exchange; Ultraviolet Rays | 2012 |
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Topics: Alkyl and Aryl Transferases; Blotting, Western; Crystallography, X-Ray; DNA Damage; DNA Repair; DNA, Fungal; Flow Cytometry; G1 Phase; Genome, Fungal; Guanine; Methylnitronitrosoguanidine; Models, Molecular; Mutation; Nitrosourea Compounds; Nucleic Acid Conformation; Protein Binding; Protein Structure, Tertiary; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription, Genetic | 2012 |
Lesion-specific DNA-binding and repair activities of human O⁶-alkylguanine DNA alkyltransferase.
Topics: DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Single-Stranded; Guanine; Humans; Kinetics; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding | 2012 |
O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.
Topics: Antineoplastic Agents; Apoptosis; Base Pair Mismatch; Cell Cycle; Cell Death; Cell Line; DNA; DNA Damage; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Guanine; Humans; Neoplasms; S Phase; Signal Transduction | 2012 |
An approach based on ultra-high pressure liquid chromatography-tandem mass spectrometry to quantify O6-methyl and O6-carboxymethylguanine DNA adducts in intestinal cell lines.
Topics: Animals; Caco-2 Cells; Chromatography, High Pressure Liquid; Colonic Neoplasms; DNA; DNA Adducts; Guanine; HT29 Cells; Humans; Nitroso Compounds; Reproducibility of Results; Tandem Mass Spectrometry | 2012 |
The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Apoptosis; Apoptosis Regulatory Proteins; G2 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; Guanine; HeLa Cells; Humans; M Phase Cell Cycle Checkpoints; Methylnitrosourea; Mice; Molecular Sequence Data; Rats | 2012 |
Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis.
Topics: Alkylating Agents; AMP-Activated Protein Kinases; Apoptosis; Carrier Proteins; DNA; Estrone; Gene Knockdown Techniques; Guanine; HeLa Cells; Humans; Leupeptins; Protein Stability | 2013 |
Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Autophagy; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Cellular Senescence; Dacarbazine; DNA Damage; DNA Mismatch Repair; DNA Modification Methylases; DNA-Binding Proteins; Glioma; Guanine; Homologous Recombination; Humans; Protein Serine-Threonine Kinases; Temozolomide; Tumor Suppressor Proteins | 2013 |
Development of a new application of the comet assay to assess levels of O6-methylguanine in genomic DNA (CoMeth).
Topics: Alkylating Agents; Animals; Comet Assay; DNA; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Genome; Guanine; Mice; Tumor Suppressor Proteins | 2013 |
A long non-coding RNA signature in glioblastoma multiforme predicts survival.
Topics: Age Factors; Brain Neoplasms; DNA Methylation; Female; Gene Expression Profiling; Glioblastoma; Guanine; Humans; Kaplan-Meier Estimate; Male; Microarray Analysis; Predictive Value of Tests; Proportional Hazards Models; RNA, Long Noncoding; Time Factors | 2013 |
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; DNA Adducts; Guanine; Humans; Lung Neoplasms; Mice, Transgenic; Microsomes; Nicotiana; Nitrosamines; Pyridines | 2014 |
Incorporation of nucleoside probes opposite O⁶-methylguanine by Sulfolobus solfataricus DNA polymerase Dpo4: importance of hydrogen bonding.
Topics: DNA Polymerase beta; Fluorescent Dyes; Guanine; Hydrogen Bonding; Molecular Structure; Nucleosides; Sulfolobus solfataricus | 2013 |
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.
Topics: Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Melanoma; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinases; Signal Transduction; Temozolomide; Tumor Suppressor Proteins | 2013 |
Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients.
Topics: Adenine; Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Chromatography, Liquid; Deoxycytidine; DNA Methylation; DNA, Neoplasm; Female; Fungal Proteins; Guanine; Humans; Indicator Dilution Techniques; Limit of Detection; Lung Neoplasms; Male; Middle Aged; Reproducibility of Results; Single-Strand Specific DNA and RNA Endonucleases; Solid Phase Extraction; Tandem Mass Spectrometry; Tumor Microenvironment | 2013 |
Development of a liquid chromatography/tandem mass spectrometry method to investigate the presence of biomarkers of DNA damage in urine related to red meat consumption and risk of colorectal cancer.
Topics: Animals; Chromatography, Liquid; Colorectal Neoplasms; Cross-Over Studies; Deoxyguanosine; Diet; Diet, Vegetarian; DNA Damage; Guanine; Humans; Limit of Detection; Meat; Tandem Mass Spectrometry | 2013 |
Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis.
Topics: Animals; Apoptosis; Azoxymethane; Colon; Guanine; O(6)-Methylguanine-DNA Methyltransferase; Rats | 2013 |
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.
Topics: Adenoma; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; Female; Guanine; Kava; Lung; Lung Neoplasms; Mice; Nitrosamines | 2014 |
Purple rice extract supplemented diet reduces DMH- induced aberrant crypt foci in the rat colon by inhibition of bacterial β-glucuronidase.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogens; Colon; Dietary Supplements; DNA Adducts; Escherichia coli; Glucuronidase; Guanine; Intestinal Mucosa; Male; Oryza; Plant Extracts; Rats; Rats, Wistar | 2014 |
Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β.
Topics: Catalytic Domain; Crystallography, X-Ray; DNA Polymerase beta; Guanine; Humans; Kinetics; Metals; Molecular Conformation; Mutagens | 2014 |
Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.
Topics: Cell Line; DNA Damage; DNA End-Joining Repair; DNA Mismatch Repair; DNA Repair; Flow Cytometry; Genes, Reporter; Genetic Techniques; Guanine; High-Throughput Nucleotide Sequencing; Humans; Mutagenesis; Plasmids; Sequence Analysis, RNA; Transcription, Genetic; Transfection | 2014 |
O⁶-carboxymethylguanine in DNA forms a sequence context-dependent wobble base-pair structure with thymine.
Topics: Base Pairing; Crystallization; Crystallography, X-Ray; DNA; Guanine; Thymine | 2014 |
Fat content and nitrite-curing influence the formation of oxidation products and NOC-specific DNA adducts during in vitro digestion of meat.
Topics: Aldehydes; Ammonia; Anaerobiosis; Animals; Colony Count, Microbial; DNA Adducts; Fatty Acids, Volatile; Guanine; Humans; Lipids; Meat; Nitrites; Nitroso Compounds; Oxidation-Reduction; Proteins; Sus scrofa | 2014 |
Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.
Topics: Animals; Carcinogens; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Female; Guanine; Kava; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Pyrones; Structure-Activity Relationship | 2014 |
Repair of O6-methylguanine adducts in human telomeric G-quadruplex DNA by O6-alkylguanine-DNA alkyltransferase.
Topics: DNA; DNA Adducts; DNA Repair; G-Quadruplexes; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Potassium; Telomere | 2014 |
O6-alkylguanine postlesion DNA synthesis is correct with the right complement of hydrogen bonding.
Topics: Archaeal Proteins; Base Pairing; DNA Adducts; DNA Damage; DNA Polymerase beta; DNA Repair; DNA Replication; DNA, Archaeal; Gene Expression; Guanine; Hydrogen Bonding; Recombinant Proteins; Sulfolobus solfataricus | 2014 |
Mismatch repair-dependent metabolism of O6-methylguanine-containing DNA in Xenopus laevis egg extracts.
Topics: Animals; Cell Extracts; DNA; DNA Damage; DNA Mismatch Repair; DNA Replication; Guanine; Ovum; Xenopus laevis | 2015 |
The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity.
Topics: Alkyl and Aryl Transferases; Alkylating Agents; Animals; Apoptosis; CHO Cells; Cricetinae; Cricetulus; DNA; DNA Adducts; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Escherichia coli Proteins; Guanine; Humans; Methylnitronitrosoguanidine; Transgenes; Tumor Suppressor Proteins | 2015 |
T-cells enhance stem cell mutagenesis in the mouse colon.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Dextran Sulfate; DNA Damage; Drug Synergism; Guanine; Inflammation; Male; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Receptors, Antigen, T-Cell, alpha-beta; Stem Cells; T-Lymphocytes | 2015 |
Noncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase κ.
Topics: Deuterium Exchange Measurement; DNA Damage; DNA-Directed DNA Polymerase; Escherichia coli Proteins; Guanine; Protein Conformation | 2015 |
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glutathione; Guanine; HCT116 Cells; Humans; Male; Mice, Inbred BALB C; Molecular Targeted Therapy; Temozolomide; Thioctic Acid; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Chromium (VI) potentiates the DNA adducts (O(6)-methylguanine) formation of N-nitrosodimethylamine in rat: implication on carcinogenic risk.
Topics: Animals; Carcinogens, Environmental; Chromium; Cytochrome P-450 CYP2E1; Dimethylnitrosamine; DNA Adducts; Drinking Water; Female; Guanine; Liver; Rats; Rats, Wistar; Risk | 2015 |
Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.
Topics: Base Sequence; Chromosomes, Human, Pair 15; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epithelial Cells; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Guanine; Humans; Longitudinal Studies; Lung Neoplasms; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Polymorphism, Single Nucleotide; Smoking; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2015 |
High resolution mass spectrometry based profiling of diet-related deoxyribonucleic acid adducts.
Topics: Aged; Aged, 80 and over; Animals; Cattle; Chromatography, High Pressure Liquid; Colonic Neoplasms; Databases, Chemical; Diet; DNA; DNA Adducts; Female; Guanine; Humans; Male; Middle Aged; Tandem Mass Spectrometry | 2015 |
Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide.
Topics: Antineoplastic Agents, Alkylating; Bone Morphogenetic Protein 7; Cell Proliferation; Cell Survival; Dacarbazine; DNA Modification Methylases; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Neoplastic Stem Cells; Temozolomide; Tumor Cells, Cultured | 2015 |
Glioblastomas with IDH1/2 mutations have a short clinical history and have a favorable clinical outcome.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Dacarbazine; DNA Methylation; Female; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Japan; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Mutation; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Temozolomide | 2016 |
Kinetic analysis of bypass of O(6)- methylguanine by the catalytic core of yeast DNA polymerase eta.
Topics: Amino Acid Motifs; Deoxyribonucleotides; DNA-Directed DNA Polymerase; Guanine; Kinetics; Protein Domains; Saccharomyces cerevisiae | 2016 |
In-Gene Quantification of O(6)-Methylguanine with Elongated Nucleoside Analogues on Gold Nanoprobes.
Topics: DNA Adducts; Exoribonucleases; Genes, ras; Genome, Human; Gold; Guanine; Humans; Metal Nanoparticles; Temperature | 2016 |
The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts.
Topics: Base Pairing; Carcinogens; DNA; DNA Adducts; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Kinetics; Models, Molecular; Nucleotides; Reproducibility of Results; Taq Polymerase; Templates, Genetic | 2016 |
Effect of O6-Substituted Guanine Analogs on O6-methylguanine DNA-methyltransferase Expression and Glioblastoma Cells Viability.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioblastoma; Guanine; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2016 |
Bypass of Mutagenic O(6)-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases.
Topics: DNA Adducts; DNA-Directed DNA Polymerase; Guanine; Humans; Mutagens; Mutation; Nitrosation; Proto-Oncogene Proteins p21(ras) | 2016 |
Dietary butyrylated high-amylose starch reduces azoxymethane-induced colonic O(6)-methylguanine adducts in rats as measured by immunohistochemistry and high-pressure liquid chromatography.
Topics: Amylose; Animals; Azoxymethane; Butyrates; Carcinogens; Chromatography, High Pressure Liquid; Colon; Diet; DNA Adducts; Guanine; Immunohistochemistry; Male; Rats, Sprague-Dawley | 2016 |
DNA-Targeted Inhibition of MGMT.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; DNA; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Guanine; Humans; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2017 |
Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.
Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Guanine; Kidney; Male; Methylazoxymethanol Acetate; Rats, Mutant Strains; Time Factors | 2017 |
Alteration in the expression of MGMT and RUNX3 due to non-CpG promoter methylation and their correlation with different risk factors in esophageal cancer patients.
Topics: Adult; Aged; Alcohol Drinking; Areca; Core Binding Factor Alpha 3 Subunit; CpG Islands; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Guanine; Humans; Male; Middle Aged; Neoplasm Grading; Promoter Regions, Genetic; Risk Factors; RNA, Messenger; Smoking; Tumor Suppressor Proteins | 2017 |
A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; Cricetulus; Dacarbazine; DNA Repair; DNA, Neoplasm; Guanine; Humans; Mutation; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide | 2017 |
Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Female; Guanine; Lung; Lung Neoplasms; Mice; Nitrosamines; Pyrones; Structure-Activity Relationship | 2017 |
Preparation of PEGylated liposomes incorporating lipophilic lomeguatrib derivatives for the sensitization of chemo-resistant gliomas.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Glioma; Guanine; Humans; Liposomes; Mice; Polyethylene Glycols; Purines | 2018 |
Molecular criteria for mutagenesis by DNA methylation: Some computational elucidations.
Topics: Alkylating Agents; Base Pairing; Computational Biology; DNA; DNA Methylation; Guanine; Nucleic Acid Conformation; Thymine | 2018 |
Reduction of Werner Syndrome Protein Enhances G:C → A:T Transition by O
Topics: Cell Line, Tumor; Guanine; Humans; Mutation; Transcription, Genetic; Werner Syndrome Helicase | 2018 |
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Transcriptional control of O
Topics: Antineoplastic Agents, Alkylating; Dacarbazine; DNA; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Temozolomide | 2018 |
Topics: Amino Acid Substitution; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Repair; G1 Phase Cell Cycle Checkpoints; Guanine; Humans; Mutagenesis; Mutation, Missense; S Phase Cell Cycle Checkpoints; Transcription, Genetic; Tumor Suppressor Protein p53 | 2018 |
Correlation Between the Residual Tumor Volume, Extent of Tumor Resection, and O
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Guanine; Humans; Male; Methyltransferases; Middle Aged; Neoplasm, Residual | 2018 |
Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Carcinogens; Cell Proliferation; Colon; Diethylnitrosamine; DNA Adducts; Drug Synergism; Guanine; Liver Neoplasms, Experimental; Male; Mutation; Rats; Rats, Wistar | 2019 |
In vitro lesion bypass by human PrimPol.
Topics: Adenine; DNA Damage; DNA Primase; DNA-Directed DNA Polymerase; Guanine; Humans; Magnesium; Multifunctional Enzymes; Uracil | 2018 |
Failure to Cite Related Studies and Report Complete Information on Patients and Tissue Samples.
Topics: DNA; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Stomach Neoplasms | 2019 |
Letter to the Editor Regarding "Computational Study of Novel Natural Inhibitors Targeting O6-Methylguanine-DNA Methyltransferase (MGMT)".
Topics: DNA; Guanine; O(6)-Methylguanine-DNA Methyltransferase | 2019 |
Fragmentation Spectra Prediction and DNA Adducts Structural Determination.
Topics: Density Functional Theory; DNA Adducts; Electrons; Guanine; Isomerism; Mass Spectrometry | 2019 |
A LONELY GUY protein of Bordetella pertussis with unique features is related to oxidative stress.
Topics: Amino Acid Sequence; Aminohydrolases; Bordetella pertussis; Cytokinins; Guanine; Humans; Oxidative Stress; Whooping Cough | 2019 |
MLH1-mediated recruitment of FAN1 to chromatin for the induction of apoptosis triggered by O
Topics: Apoptosis; Chromatin; DNA Damage; Endodeoxyribonucleases; Exodeoxyribonucleases; Guanine; HeLa Cells; Humans; Multifunctional Enzymes; MutL Protein Homolog 1 | 2020 |
Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.
Topics: Cell Line, Tumor; Guanine; Humans; Lung Neoplasms; Mesothelioma; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2020 |
Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of
Topics: Alkyl and Aryl Transferases; Guanine; Humans; Models, Molecular; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Sulfhydryl Compounds | 2020 |
The Association of BAP1 Loss-of-Function With the Defect in Homologous Recombination Repair and Sensitivity to PARP-Targeted Therapy.
Topics: DNA; DNA Repair; Guanine; Humans; Lung Neoplasms; Mesothelioma; Methyltransferases; Poly(ADP-ribose) Polymerase Inhibitors; Recombinational DNA Repair; Temozolomide; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2020 |
Response to Letter to the Editor by Yang et al.
Topics: DNA; Guanine; Humans; Lung Neoplasms; Mesothelioma; Methyltransferases; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2020 |
Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension.
Topics: DNA Damage; G-Quadruplexes; Guanine; HEK293 Cells; Humans; Point Mutation; RNA; Shelterin Complex; Telomerase; Telomere; Telomere-Binding Proteins | 2020 |
Site-specific RNA methylation by a methyltransferase ribozyme.
Topics: Adenosine; Base Sequence; Biocatalysis; Guanine; Methylation; Methyltransferases; Plasmids; RNA, Catalytic; RNA, Transfer; S-Adenosylmethionine | 2020 |
O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; DNA; DNA Breaks, Double-Stranded; DNA Damage; Guanine; Homologous Recombination; Humans; Methyltransferases; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms | 2021 |
PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Guanine; Humans; Mice; Poly ADP Ribosylation; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Proteins | 2021 |
Genetic and environmental determinants of O
Topics: Aged; Aging; Antineoplastic Agents, Alkylating; Cohort Studies; CpG Islands; Cross-Sectional Studies; Denmark; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Environment; Epigenomics; Female; Gene Silencing; Glioblastoma; Guanine; Humans; Longitudinal Studies; Male; Methyltransferases; Middle Aged; Tumor Suppressor Proteins; Twins, Dizygotic; Twins, Monozygotic | 2021 |
DNA methyltransferase 1 inhibits O
Topics: Carcinoma, Squamous Cell; Cell Proliferation; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Guanine; Head and Neck Neoplasms; Humans; Methyltransferases; Transferases | 2021 |
O-6-methylguanine-DNA methyltransferase (MGMT)-methylated pineal glioblastoma in young women.
Topics: Brain Neoplasms; DNA; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Tumor Suppressor Proteins | 2022 |
Mechanism of DNA methylation-mediated downregulation of O6-methylguanine-DNA methyltransferase in cartilage injury of Kashin-Beck disease.
Topics: Cartilage, Articular; Chondrocytes; Decitabine; DNA; DNA Methylation; Down-Regulation; Guanine; Humans; Kashin-Beck Disease; RNA, Messenger; Selenium; T-2 Toxin | 2022 |
Non-invasive prediction of p53 and Ki-67 labelling indices and O-6-methylguanine-DNA methyltransferase promoter methylation status in adult patients with isocitrate dehydrogenase wild-type glioblastomas using diffusion-weighted imaging and dynamic suscept
Topics: Adult; Brain Neoplasms; DNA; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Magnetic Resonance Imaging; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Perfusion; Retrospective Studies; Tumor Suppressor Protein p53 | 2022 |
KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.
Topics: Alkylating Agents; Dacarbazine; DNA; DNA Repair; Epigenesis, Genetic; Guanine; O(6)-Methylguanine-DNA Methyltransferase; Parthanatos; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide | 2022 |
Are anaplastic lymphoma kinase (ALK) and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation driver biomarkers of pulmonary neuroendocrine tumors (NETs) and carcinomas (NECs)?
Topics: Anaplastic Lymphoma Kinase; Biomarkers; Carcinoid Tumor; Carcinoma, Neuroendocrine; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Guanine; Humans; Lung Neoplasms; Neuroendocrine Tumors; O(6)-Methylguanine-DNA Methyltransferase; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2022 |
Long non-coding RNA X-inactive specific transcript suppresses the progression of hepatocellular carcinoma through microRNA-221-3p-targeted regulation of O6-methylguanine-DNA methyltransferase.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA; Guanine; Liver Neoplasms; MicroRNAs; O(6)-Methylguanine-DNA Methyltransferase; RNA, Long Noncoding | 2022 |
A simple and rapid mix-and-read assay for sensitive detection of O
Topics: DNA; Guanine; O(6)-Methylguanine-DNA Methyltransferase | 2022 |
PARP1-MGMT complex underpins pathway crosstalk in O
Topics: Adenosine Diphosphate; Alkylating Agents; Chromatin; DNA; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Poly (ADP-Ribose) Polymerase-1; Ribose; Temozolomide; Tumor Suppressor Proteins | 2022 |