o-(6)-methylguanine has been researched along with dimethylnitrosamine in 71 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 47 (66.20) | 18.7374 |
1990's | 20 (28.17) | 18.2507 |
2000's | 3 (4.23) | 29.6817 |
2010's | 1 (1.41) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Brésil, H; Margison, GP; Montesano, R | 1 |
Pegg, AE | 2 |
Hui, G; Pegg, AE | 1 |
Den Engelse, L; Scherer, E; Van Benthem, J; Vermeulen, E; Wild, CP; Winterwerp, HH | 1 |
Chen, JS; Guo, ZL; Liu, ZQ; Xiao, Y; Zhu, JQ | 1 |
Butler, WH; Fan, CY; O'Connor, PJ | 1 |
Keefer, LK; Kleihues, P; Nims, RW; Reist, EJ; Schmerold, I; von Hofe, E | 1 |
Hecht, SS; Peterson, LA | 1 |
Den Engelse, L; Scherer, E; Van Benthem, J; Vermeulen, E; Wild, CP | 1 |
Anderson, MW; Belinsky, SA; Devereux, TR | 2 |
Arce, C; Dumenco, LL; Gerson, SL; Norton, K; Wagner, T; Yun, J | 1 |
Archer, MC; Chin, W; Cooper, DP; Dai, WD; Lee, V; O'Connor, PJ | 1 |
Zhang, PC | 1 |
Archer, MC; Catz-Biro, L; Hirani-Hojatti, S; Milligan, JR | 1 |
Den Engelse, L; Scherer, E; Van Den Berg, T; Vermeulen, E; Winterwerp, HH | 1 |
Bradbrook, C; Charlesworth, JD; Chu, YH; Cooper, DP; Margison, GP; O'Connor, PJ; Styles, J | 1 |
Barch, DH; Fox, CC | 2 |
Citti, L; Coccia, P; Diomede, L; Mariani, L; Romano, M; Salmona, M | 1 |
den Engelse, L; Jenner, AA; Scherer, E | 1 |
Cleary, CM; Friedman, S; Parsa, I | 1 |
Craddock, VM; Henderson, AR | 1 |
Billett, MA; O'Connor, PJ; Ryan, AJ | 1 |
Bürkle, V; Danecki, S; Grotzke, J; Schweinsberg, F; von Karsa, L | 1 |
Kleihues, P; von Hofe, E | 1 |
Devor, D; Kaufman, DG; Kaufmann, WK; Rice, JM; Wenk, ML | 1 |
Bosan, WS; Gaworski, CL; MacEwen, JD; Newberne, PM; Shank, RC | 1 |
Mikhaĭlenko, VM; Rubenchik, BL | 1 |
Carmella, SG; Chung, FL; Hecht, SS; Wang, M | 1 |
Castonguay, A; Hecht, SS; Rivenson, A; Trushin, N | 1 |
Archer, MC; Silinskas, KC; Zucker, PF | 1 |
Likhachev, A; Montesano, R; Planche-Martel, G; Wild, CP | 1 |
Margison, GP | 1 |
Columbano, A; Ledda, GM; Rajalakshmi, S; Rao, PM; Sarma, DS | 2 |
Bresil, H; Cooper, DP; Margison, GP; Montesano, R; O'Connor, PJ; Planche-Martel, G; Smith, RA | 1 |
Lijinsky, W; Pegg, AE | 1 |
Brésil, H; Margison, GP; Montesano, R; Pegg, AE; Planche-Martel, G | 2 |
Archer, MC; Labuc, GE; Silinskas, KC; Zucker, PF | 1 |
Chu, YH; Craig, AW; O'Connor, PJ | 1 |
Chu, YH; Margison, GP; Maru, GB; O'Connor, PJ | 1 |
Bamborschke, S; Kleihues, P; Margison, GP; Maru, GB; O'Connor, PJ | 1 |
Mace, R; Swann, PF | 1 |
Kerler, R; Rabes, HM; Rode, G; Wilhelm, R | 1 |
Bedell, MA; Belinsky, SA; Swenberg, JA | 1 |
Kyrtopoulos, SA; Swann, PF | 1 |
Kyrtopoulos, SA; Vrotsou, B | 1 |
De Brij, RJ; Den Engelse, L; Philippus, EJ | 1 |
Lawrence, JF; Leduc, R; Ryan, JJ | 1 |
Bennett, RA; Pegg, AE; Perry, W | 1 |
Craig, AW; Galbraith, AI; Itzhaki, RF; Margison, GP | 1 |
Abanobi, SE; Columbano, A; Mulivor, RA; Rajalakshmi, S; Sarma, DS | 1 |
Pegg, AE; Umbenhauer, DR | 1 |
Anderson, LM; Chhabra, S; Kyrtopoulos, SA; Souliotis, VL | 1 |
Bean, CL; Bradt, CI; Galloway, SM; Greenwood, SK; Hill, RB | 1 |
Archer, MC; Xie, XY | 1 |
Anderson, LM; Chhabra, SK; Harbaugh, JW; Jones, AB; Krasnow, SW; Kyrtopoulos, SA; Souliotis, VL | 1 |
Hall, J; Montesano, R; Takahashi, S | 1 |
Conran, PB; Geil, RG; Morse, MA; Schut, HA; Siglin, JC; Stoner, GD | 1 |
D'Ambrosio, SM; Gopalakrishnan, R; Lu, J; Morse, MA; Peterson, LA; Stoner, GD; Wani, G | 1 |
Morse, MA; Stoner, GD | 1 |
Anderson, LM; Chhabra, SK; Georgiadis, P; Kyrtopoulos, SA; Pletsa, V; Souliotis, VL; Valavanis, C | 1 |
Arimoto-Kobayashi, S; Hayatsu, H; Kaji, K; Sweetman, GM | 1 |
Crankshaw, DL; Donaldson, EE; Kenney, PJ; Peterson, LA; Thomson, NM | 1 |
Blackwood, M; Carlton, PS; Gupta, A; Kresty, LA; Lu, J; Morgan, C; Morse, MA; Stoner, GD | 1 |
Deangelo, AB; Hobbie, KR; King, LC; Law, JM; Winn, RN | 1 |
Craig, AW; Margison, GP; Ockey, CH; Swindell, JA | 1 |
Hu, J; Jiang, J; Ma, F; Zhang, Z | 1 |
3 review(s) available for o-(6)-methylguanine and dimethylnitrosamine
Article | Year |
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Methylated purines formed in DNA by dimethylnitrosamine in rats previously exposed to hepatotoxic and hepatocarcinogenic regimes: effects on the repair of O6-methylguanine.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Dimethylnitrosamine; DNA; DNA Repair; Ethanolamines; Guanine; Liver; Male; Quinoxalines; Rats; Rats, Inbred Strains | 1985 |
Enhanced repair of O6-alkylguanine in mammalian tissues.
Topics: 2-Acetylaminofluorene; Adenine; Aflatoxin B1; Aflatoxins; Alkylating Agents; Alkylation; Animals; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Gerbillinae; Guanine; Hepatectomy; Liver; Methylnitrosourea; Mice; Rats; Rodentia; Species Specificity | 1984 |
DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinogens, Environmental; Dimethylnitrosamine; DNA Adducts; DNA Damage; DNA Methylation; Erythrocebus patas; Ethanol; Female; Guanine; Humans; Leukocytes; Liver; Mice; Mice, Transgenic; Neoplasms; Nitroso Compounds; Procarbazine | 1997 |
68 other study(ies) available for o-(6)-methylguanine and dimethylnitrosamine
Article | Year |
---|---|
Increased excision of O6-methylguanine from rat liver DNA after chronic administration of dimethylnitrosamine.
Topics: Animals; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Rats | 1979 |
Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA.
Topics: Animals; Cattle; Depression, Chemical; Dimethylnitrosamine; DNA; Guanine; Kidney; Liver; Methylation; Nitrosamines; Rats | 1978 |
Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA; Female; Guanine; In Vitro Techniques; Kidney; Liver; Nitrosamines; Proteins; Rats | 1978 |
Accumulation of O6- and 7-methylguanine in DNA of N-nitroso-N-methylbenzylamine-treated rats is restricted to non-target organs for N-nitroso-N-methylbenzylamine-induced carcinogenesis.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Guanine; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1992 |
The effects of Chinese tea on the methylation of DNA by the esophageal carcinogen N-nitrosomethylbenzylamine.
Topics: Animals; Anticarcinogenic Agents; Autoradiography; Dimethylnitrosamine; DNA; Esophageal Neoplasms; Guanine; Male; Methylation; Purine Nucleotides; Rats; Rats, Inbred Strains; Tea | 1991 |
Promutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA Damage; Guanine; Male; Neoplasms, Experimental; Rats | 1991 |
Beta-deuteration of N-nitrosoethylmethylamine causes a shift in DNA methylation from rat liver to esophagus.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Chromatography; Deuterium; Dimethylnitrosamine; DNA; Esophagus; Guanine; Kidney; Liver; Lung; Male; Methylation; Microsomes, Liver; Nitrosamines; Rats; Rats, Inbred F344 | 1991 |
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Female; Guanine; Hydroxylation; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1991 |
Immunocytochemical localization of DNA adducts induced by a single dose of N-nitroso-N-methylbenzylamine in target and non-target tissues of tumor formation in the rat.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA Repair; DNA, Neoplasm; Guanine; Immunohistochemistry; Male; Methylation; Organ Specificity; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.
Topics: Animals; Base Sequence; Codon; Dimethylnitrosamine; DNA; Drug Resistance; Gene Expression Regulation, Neoplastic; Genes, ras; Guanine; Incidence; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Molecular Sequence Data; Mutation; Nitrosamines; Proto-Oncogenes; Thymine; Time Factors | 1991 |
Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene.
Topics: Animals; Dietary Proteins; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Gene Expression; Guanine; Liver; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Time Factors | 1991 |
DNA methylation in specific cells of rat liver by N-nitrosodimethylamine and N-nitrosomethylbenzylamine.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Liver Neoplasms, Experimental; Male; Methylation; Rats; Species Specificity | 1991 |
[The determination of DNA adducts in liver and lung of mice exposed to dimethylnitrosamine].
Topics: Animals; Dimethylnitrosamine; DNA; DNA Damage; Female; Guanine; Liver; Lung; Male; Mice | 1990 |
Methylation of DNA by three N-nitroso compounds: evidence for sequence specific methylation by a common intermediate.
Topics: Base Sequence; Dimethylnitrosamine; DNA; DNA Restriction Enzymes; Guanine; Methylation; Methylnitrosourea; Nitrosamines; Nitroso Compounds; Plasmids; Polydeoxyribonucleotides | 1989 |
Immunocytochemical analysis of O6-alkylguanine shows tissue specific formation in and removal from esophageal and liver DNA in rats treated with methylbenzylnitrosamine, dimethylnitrosamine, diethylnitrosamine and ethylnitrosourea.
Topics: Animals; Carcinogens; Cell Nucleus; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; DNA Repair; Esophagus; Ethylnitrosourea; Female; Guanine; Immunoenzyme Techniques; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Substrate Specificity | 1989 |
Selective inhibition of methylbenzylnitrosamine-induced formation of esophageal O6-methylguanine by dietary ellagic acid in rats.
Topics: Animals; Benzopyrans; Cattle; Chromatography, High Pressure Liquid; Diet; Dimethylnitrosamine; DNA; Ellagic Acid; Esophagus; Guanine; Male; Methylation; Rats; Rats, Inbred Strains | 1988 |
Liver DNA alkylation after a single carcinogenic dose of dimethylnitrosamine to newborn and adult CFW Swiss mice.
Topics: Alkylation; Animals; Animals, Newborn; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase; Oxidoreductases, N-Demethylating | 1988 |
Immunocytochemical studies on the formation and repair of O6-alkylguanine in rat tissues.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Ethylnitrosourea; Guanine; Immunohistochemistry; Islets of Langerhans; Kidney Glomerulus; Liver; Male; Muscle, Smooth; Precancerous Conditions; Rats; Spermatogonia; Tissue Distribution | 1987 |
Factors regulating activation and DNA alkylation by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and nitrosodimethylamine in rat lung and isolated lung cells, and the relationship to carcinogenicity.
Topics: Alkylation; Animals; Antibodies; Benzoflavones; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Isoenzymes; Lung; Methylation; Nitrosamines; Rats | 1988 |
Visualization of O6-methylguanine in target cell nuclei of dimethylnitrosamine-treated human pancreas by a murine monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Carbon Radioisotopes; Cell Nucleus; Dimethylnitrosamine; Guanine; Humans; Mice; Organ Culture Techniques; Pancreas | 1987 |
Dietary zinc deficiency increases the methylbenzylnitrosamine-induced formation of O6-methylguanine in the esophageal DNA of the rat.
Topics: Animals; Deficiency Diseases; Dimethylnitrosamine; DNA; Esophageal Neoplasms; Esophagus; Guanine; Male; Mutation; Rats; Rats, Inbred Strains; Zinc | 1987 |
Effect of N-nitrosamines carcinogenic for oesophagus on O6-alkyl-guanine-DNA-methyl transferase in rat oesophagus and liver.
Topics: Alkylation; Animals; Cysteine; Dimethylnitrosamine; DNA; DNA Repair; DNA Replication; Esophageal Neoplasms; Esophagus; Guanine; Liver; Liver Neoplasms, Experimental; Methyltransferases; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1986 |
Selective repair of methylated purines in regions of chromatin DNA.
Topics: Animals; Chromatin; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Male; Methylation; Purines; Rats; Rats, Inbred Strains | 1986 |
Modifying effects of disulfiram on DNA adduct formation and persistence of benzaldehyde in N-nitroso-N-methyl-benzylamine-induced carcinogenesis in rats.
Topics: Animals; Benzaldehydes; Carcinogens; Dimethylnitrosamine; Disulfiram; DNA Repair; DNA, Neoplasm; Esophagus; Female; Guanine; Hyperplasia; Rats; Respiratory System; Respiratory Tract Neoplasms | 1986 |
Comparative studies on hepatic DNA alkylation in rats by N-nitrosomethylethylamine and N-nitrosodimethylamine plus N-nitrosodiethylamine.
Topics: Alkylation; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Male; Mathematics; Rats; Rats, Inbred F344 | 1986 |
Cell cycle-dependent initiation of hepatocarcinogenesis in rats by methyl(acetoxymethyl)nitrosamine.
Topics: Animals; Carcinogens; Cell Cycle; Cell Division; Dimethylnitrosamine; DNA Repair; DNA Replication; Guanine; Hepatectomy; Hydrocortisone; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Time Factors | 1987 |
Methylation of DNA guanine during the course of induction of liver cancer in hamsters by hydrazine or dimethylnitrosamine.
Topics: Animals; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA; Guanine; Hydrazines; Liver; Liver Neoplasms, Experimental; Male; Mesocricetus; Methylation; Tissue Distribution | 1987 |
[DNA alkylation during endogenous synthesis of N-nitrosodimethylamine].
Topics: Alkylation; Animals; Dimethylamines; Dimethylnitrosamine; DNA; DNA Damage; Guanine; Kidney; Liver; Lung; Male; Rats; Sodium Nitrite | 1987 |
Effects of butylated hydroxyanisole on the tumorigenicity and metabolism of N-nitrosodimethylamine and N-nitrosopyrrolidine in A/J mice.
Topics: Animals; Anisoles; Biotransformation; Butylated Hydroxyanisole; Dimethylnitrosamine; Female; Glutathione; Glutathione Transferase; Guanine; Lung; Lung Neoplasms; Mice; Microsomes; Microsomes, Liver; N-Nitrosopyrrolidine; Nitrosamines | 1986 |
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA, Neoplasm; Guanine; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats | 1986 |
Formation of O6-methylguanine in rat liver DNA by nitrosamines does not predict initiation of preneoplastic foci.
Topics: Animals; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Guanine; Liver; Liver Neoplasms, Experimental; Male; Methylation; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
Modulation of repair of O6-methylguanine in parenchymal and nonparenchymal liver cells of rats treated with dimethylnitrosamine.
Topics: Alkylation; Animals; Carbon Radioisotopes; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Liver Neoplasms; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1985 |
Chronic or acute administration of various dialkylnitrosamines enhances the removal of O6-methylguanine from rat liver DNA in vivo.
Topics: Animals; Chromatography, Gel; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Nitrosamines; Purines; Rats; RNA | 1982 |
In vivo replication of carcinogen-modified rat liver DNA: increased susceptibility of O6-methylguanine compared to N-7-methylguanine in replicated DNA to S1-nuclease.
Topics: Animals; Dimethylnitrosamine; DNA Replication; Endonucleases; Guanine; Liver; Male; Methylation; Rats; Single-Strand Specific DNA and RNA Endonucleases; Substrate Specificity | 1980 |
Saturation of repair system for O6-methylguanine in rat liver DNA by pretreatment with cyclic nitrosamines.
Topics: Animals; Binding Sites; Cyclization; Dimethylnitrosamine; DNA Repair; Female; Guanine; Liver; Nitrosamines; Rats; Rats, Inbred Strains | 1984 |
Stability and capacity of dimethylnitrosamine-induced O6-methylguanine repair system in rat liver.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA Repair; DNA Replication; Guanine; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1983 |
Formation of O6-methylguanine in regenerating rat liver by N-nitrosomethylbenzylamine is not sufficient for initiation of preneoplastic foci.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Guanine; Kinetics; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1984 |
Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1.
Topics: Adenine; Aflatoxin B1; Aflatoxins; Animals; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Rats; Stimulation, Chemical | 1981 |
Effects of carcinogens and partial hepatectomy upon the hepatic O6-methylguanine repair system in mice.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cell-Free System; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Hepatectomy; Liver; Liver Regeneration; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Rats; Rats, Inbred Strains | 1982 |
DNA methylation by dimethylnitrosamine in the Mongolian gerbil (Meriones unguiculatus): indications of a deficient, noninducible hepatic repair system for O6-methylguanine.
Topics: Animals; Dimethylnitrosamine; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; Dose-Response Relationship, Drug; Gerbillinae; Guanine; Liver; Male; Methyltransferases; Time Factors | 1983 |
Formation and subsequent repair of alkylation lesions in tissues of rodents treated with nitrosamines.
Topics: Alkylation; Animals; Cricetinae; Dimethylnitrosamine; DNA; DNA Repair; Female; Guanine; Hypophysectomy; In Vitro Techniques; Kidney; Liver; Male; Mesocricetus; Rats; Species Specificity; Thyroidectomy | 1980 |
Changes in O6-methylguanine disappearance from rat liver DNA during chronic dimethylnitrosamine administration. A possible similarity between the system removing O6-methylguanine from DNA in rat liver and in Escherichia coli adapted to N-methyl-N'-nitro-N
Topics: Animals; Dimethylnitrosamine; DNA; DNA, Bacterial; Enzyme Induction; Escherichia coli; Female; Guanine; Liver; Methylnitronitrosoguanidine; Rats; Time Factors | 1980 |
Dose- and cell cycle-dependent O6-methylguanine elimination from DNA in regenerating rat liver after [14C]dimethylnitrosamine injection.
Topics: Adenine; Animals; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Guanine; Interphase; Liver; Liver Regeneration; Male; Rats | 1982 |
Effect of chronic ethanol diet on the replication, alkylation, and repair of DNA from hepatocytes and nonparenchymal cells following dimethylnitrosamine administration.
Topics: Alkylation; Animals; Cell Separation; Dimethylnitrosamine; DNA; DNA Repair; DNA Replication; Ethanol; Guanine; Liver; Male; Rats; Rats, Inbred F344 | 1982 |
Susceptibility of dimethylnitrosamine induced O6-methylguanine containing regions in in vivo replicated, hybrid rat liver DNA towards S1 nuclease.
Topics: Animals; Bromodeoxyuridine; Deoxyribonucleases; Dimethylnitrosamine; DNA; DNA Replication; Guanine; Liver; Male; Methylation; Nucleic Acid Hybridization; Rats | 1980 |
The use of radioimmunoassay to study the formation and disappearance of O6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA Repair; DNA, Satellite; Guanine; Liver; Male; Methylguanidine; Mice; Rabbits; Radioimmunoassay | 1980 |
The formation and repair of O6-methylguanine in rat liver nucleolar DNA after dimethylnitrosamine administration studied by radioimmunoassay.
Topics: Animals; Cell Nucleolus; Deoxyguanosine; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Radioimmunoassay; Rats; Rats, Inbred Strains | 1981 |
O6-alkylguanine and structural modifications in liver DNA of dialkylnitrosamine-treated rats.
Topics: Animals; Dimethylnitrosamine; DNA; DNA Repair; DNA, Single-Stranded; Dose-Response Relationship, Drug; Female; Guanine; Liver; Nitrosamines; Rats; Rats, Inbred Strains | 1981 |
The determination of O6-methyl- and 7-methylguanine in mouse liver DNA from dimethylnitrosamine-treated mice by high-performance liquid chromatography with UV absorbance detection.
Topics: Animals; Chromatography, High Pressure Liquid; Dimethylnitrosamine; DNA; Guanine; Hydrolysis; Liver; Mice; Spectrophotometry, Ultraviolet | 1981 |
Effect of partial hepatectomy on removal of O6-methylguanine from alkylated DNA by rat liver extracts.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA Repair; Female; Guanine; Hepatectomy; Liver; Liver Regeneration; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Proteins; Rats; Time Factors | 1981 |
Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.
Topics: Animals; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Kidney; Liver; Lung; Male; Rats; Time Factors | 1980 |
Distribution and repair of O6-methylguanine in different fractions of rat liver DNA after dimethylnitrosamine administration.
Topics: Animals; Chromatin; Dimethylnitrosamine; DNA Repair; DNA, Single-Stranded; Guanine; Liver; Male; Methylation; Nucleic Acid Denaturation; Rats | 1980 |
In vivo replication of hepatic deoxyribonucleic acid of rats treated with dimethylnitrosamine: presence of dimethylnitrosamine-induced O6-methylguanine, N7-methylguanine, and N3-methyladenine in the replicated hybrid deoxyribonucleic acid.
Topics: Adenine; Animals; Dimethylnitrosamine; DNA Replication; Guanine; Liver; Male; Nucleic Acid Hybridization; Rats | 1980 |
Metabolism of dimethylnitrosamine and subsequent removal of O6-methylguanine from DNA by isolated rat hepatocytes.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA; Female; Guanine; In Vitro Techniques; Liver; Methylnitrosourea; Rats | 1981 |
Dosimetry of O6-methylguanine in rat DNA after low-dose, chronic exposure to N-nitrosodimethylamine (NDMA). Implications for the mechanism of NDMA hepatocarcinogenesis.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; DNA Adducts; DNA Repair; Dose-Response Relationship, Drug; Female; Guanine; Kinetics; Liver; Liver Neoplasms, Experimental; Rats; Rats, Inbred WF; Time Factors; Water Supply | 1995 |
A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells.
Topics: Alkylating Agents; B-Lymphocytes; Cell Line; Chromosome Aberrations; Dimethylnitrosamine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Erythroid Precursor Cells; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1995 |
Metabolism of N-nitrosomethylbenzylamine by microsomes from perivenous and periportal hepatocytes.
Topics: Animals; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; gamma-Glutamyltransferase; Guanine; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley | 1994 |
O6-methylguanine DNA adduct formation and modulation by ethanol in placenta and fetal tissues after exposure of pregnant patas monkeys to N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA Adducts; DNA Damage; Erythrocebus patas; Ethanol; Female; Fetus; Guanine; Maternal-Fetal Exchange; Placenta; Pregnancy | 1995 |
Temporal cell-type-specific mRNA expression of O6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine.
Topics: Administration, Oral; Animals; Base Sequence; Blotting, Northern; Carcinogens; Dimethylnitrosamine; DNA Adducts; Guanine; Immunohistochemistry; In Situ Hybridization; Liver; Male; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Rats; RNA Probes; RNA, Messenger; Time Factors | 1996 |
O6-methylguanine levels and histopathological changes in the rat esophagus and liver following single and repeated administration of N-nitrosomethylbenzylamine.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Dose-Response Relationship, Drug; Esophagus; Guanine; Liver; Male; Rats; Rats, Inbred F344 | 1996 |
Mechanism of enhancement of esophageal tumorigenesis by 6-phenylhexyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Dimethylnitrosamine; Esophagus; Guanine; Isothiocyanates; Male; Rats; Rats, Inbred F344 | 1997 |
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; DNA Methylation; Dose-Response Relationship, Drug; Ellagic Acid; Esophageal Neoplasms; Female; Guanine; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
Mutation and formation of methyl- and hydroxylguanine adducts in DNA caused by N-nitrosodimethylamine and N-nitrosodiethylamine with UVA irradiation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Bacterial Proteins; Deoxyguanosine; Diethylnitrosamine; Dimethylnitrosamine; DNA; DNA Adducts; DNA Repair; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Proteins; Guanine; Methyltransferases; Mutagenesis; Mutagenicity Tests; Oxidation-Reduction; Plasmids; Salmonella typhimurium; Ultraviolet Rays | 1997 |
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2001 |
Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.
Topics: Animals; Carcinogens; Chemoprevention; Diet; Dimethylnitrosamine; DNA Adducts; Ellagic Acid; Esophageal Neoplasms; Freeze Drying; Fruit; Guanine; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 2001 |
Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment.
Topics: Animals; Animals, Genetically Modified; Carcinogens; Dimethylnitrosamine; DNA; DNA Adducts; Dose-Response Relationship, Drug; Guanine; Immunohistochemistry; Liver; Male; Models, Biological; Mutagenicity Tests; Mutation; Oryzias; Random Allocation; Rats; Rats, Inbred F344; Rats, Transgenic; Risk Assessment; Water Supply | 2009 |
The effects of a single dose of dimethylnitrosamine in the Chinese hamster and the persistence of DNA alkylation products in selected tissues.
Topics: Alkylation; Animals; Cricetinae; Cricetulus; Dimethylnitrosamine; DNA; Drinking Water; Guanine; Kidney; Liver; Liver Neoplasms, Experimental; Lung; Male; Organ Specificity | 1980 |
Chromium (VI) potentiates the DNA adducts (O(6)-methylguanine) formation of N-nitrosodimethylamine in rat: implication on carcinogenic risk.
Topics: Animals; Carcinogens, Environmental; Chromium; Cytochrome P-450 CYP2E1; Dimethylnitrosamine; DNA Adducts; Drinking Water; Female; Guanine; Liver; Rats; Rats, Wistar; Risk | 2015 |