o-(6)-methylguanine has been researched along with dacarbazine in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 8 (21.05) | 18.2507 |
| 2000's | 10 (26.32) | 29.6817 |
| 2010's | 14 (36.84) | 24.3611 |
| 2020's | 5 (13.16) | 2.80 |
| Authors | Studies |
|---|---|
| Bonfanti, M; Catapano, CV; Citti, L; D'Incalci, M; Taverna, P | 1 |
| Boussiotis, VA; Kyrtopoulos, SA; Pangalis, GA; Souliotis, VL | 1 |
| Tisdale, MJ | 1 |
| Boussiotis, VA; Kyrtopoulos, SA; Pangalis, GA; Souliotis, VL; Valavanis, C | 2 |
| Gerson, SL; Liu, L; Markowitz, S | 1 |
| Bailey, JA; Cooper, DP; Deans, B; Elder, RH; Heeran, MC; Jansen, JG; Margison, GP; Mynett, KJ; Rafferty, JA; van Zeeland, AA; Watson, AJ; Weeks, RJ; Wijnhoven, SW; Willington, MA | 1 |
| Ganesan, TS; Harris, AL; Kyrtopoulos, SA; Mitchell, K; Philip, PA; Salisbury, A; Souliotis, VL; Tates, AD; van Delft, JH | 1 |
| Bonmassar, E; Franco, D; Graziani, G; Levati, L; Roy, R; Serafino, A; Tentori, L; Turriziani, M | 1 |
| Goodger, S; Kelly, J; Margison, GP; Middleton, MR; Thatcher, N | 1 |
| Kyrtopoulos, SA; Psaroudi, MC | 1 |
| Arance, A; Lee, SM; Margison, GP; Middleton, MR; Thatcher, N; Wood, M | 1 |
| Baumgartner, M; Kaina, B; Roos, W | 1 |
| Aghi, M; Martuza, RL; Rabkin, S | 1 |
| Batista, LF; Kaina, B; Menck, CF; Naumann, SC; Roos, WP; Weller, M; Wick, W | 1 |
| Darga, TE; Dolan, ME; Kufe, DW; Weichselbaum, RR; Wu, MH; Yamini, B; Yu, X | 1 |
| Ancheta, K; Chtchetinin, J; Cloughesy, T; Lai, A; Nghiemphu, PL; Remington, M | 1 |
| Kaina, B; Kiedron, O; Naumann, SC; Nikolova, T; Quiros, S; Roos, WP; Zdzienicka, MZ | 1 |
| Coffey, M; Hollywood, D; Lawler, M; Marignol, L; Marples, B; Martin, L | 1 |
| Baumann, RP; Ishiguro, K; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, YL | 1 |
| Dianov, GL; Digweed, M; Eich, M; Kaina, B; Roos, WP | 1 |
| Jin, YH; Liu, HY; Shu, F; Wang, QJ; Wang, Z; Yang, Y; Zhang, WB | 1 |
| Cai, W; Cui, W; Harutyunyan, N; Ji, L; Keshelava, N; Maldonado, NV; Reynolds, CP; Sposto, R | 1 |
| Bradshaw, TD; Stevens, MF; Zhang, J | 1 |
| Christmann, M; Kaina, B; Knizhnik, AV; Nikolova, T; Quiros, S; Roos, WP; Tomaszowski, KH | 1 |
| Eich, M; Kaina, B; Nikolova, T; Roos, WP | 1 |
| Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N | 1 |
| Boldorini, R; Buosi, R; Gaudino, E; Mancuso, G; Mercalli, F; Mezzapelle, R; Miglio, U; Paganotti, A; Rena, O; Veggiani, C | 1 |
| Bui, Y; Cloughesy, TF; Hong, I; Lai, A; Liau, LM; McBride, WH; Menjivar, JC; Nelson, SF; Stream, A; Tso, CL; Tso, JL; Yamada, K; Yang, S; Yong, WH; Zhang, Y | 1 |
| Arita, H; Fukushima, S; Ichimura, K; Matsushita, Y; Miyakita, Y; Narita, Y; Ohno, M; Shibui, S; Takami, H; Yonezawa, M; Yoshida, A | 1 |
| Luedtke, NW; Marsoner, T; Schmidt, OP; Triemer, T | 1 |
| Goodfellow, E; Jean-Claude, B; Senhaji Mouhri, Z | 1 |
| Chumakova, A; Lathia, JD | 1 |
| de Groot, JF; Gao, F; Koul, D; Li, X; Wu, S; Yung, WKA | 1 |
| Chamallamudi, MR; Kumar, G; Kumar, N; Nandakumar, K; Rao, V; Thorat, ND; Vibhavari, RJA | 1 |
| Bao, L; Kumar, A; Luo, W; Wang, C; Wang, Y; Xing, C; Yang, M; Zhou, M | 1 |
| Baek, JY; Beom, SH; Cha, Y; Choi, J; Choi, MK; Hong, YS; Kim, J; Kim, JE; Kim, JH; Kim, SY; Kim, TW; Lee, JS; Lim, SB; Oh, CR; Park, IJ; Park, JH | 1 |
| Badalamenti, G; Barretta, ML; Buonaiuto, M; Cannella, L; Chiariotti, L; Clemente, O; De Chiara, AR; Della Monica, R; Di Marzo, M; Di Mauro, A; Guida, M; Iervolino, D; Marretta, AL; Tafuto, S; Vincenzi, B | 1 |
1 review(s) available for o-(6)-methylguanine and dacarbazine
| Article | Year |
|---|---|
Temozolomide Resistance: A Multifarious Review on Mechanisms Beyond
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2023 |
3 trial(s) available for o-(6)-methylguanine and dacarbazine
| Article | Year |
|---|---|
O6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: results of a phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Female; Guanine; Humans; Male; Melanoma; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2000 |
Frequency of O⁶-methylguanine-DNA methyltransferase promoter methylation in cytological samples from small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Dacarbazine; DNA Methylation; Glioma; Guanine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Small Cell Lung Carcinoma; Temozolomide | 2015 |
Preoperative Chemoradiotherapy With Capecitabine With or Without Temozolomide in Patients With Locally Advanced Rectal Cancer: A Prospective, Randomised Phase II Study Stratified by O
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Capecitabine; Chemoradiotherapy; Dacarbazine; DNA; DNA Methylation; DNA Repair Enzymes; Glioblastoma; Humans; Prospective Studies; Rectal Neoplasms; Temozolomide | 2023 |
34 other study(ies) available for o-(6)-methylguanine and dacarbazine
| Article | Year |
|---|---|
Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas.
Topics: Alkalies; Alkylation; Animals; Antineoplastic Agents; Cell Division; Dacarbazine; DNA Damage; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Guanine; Leukemia L1210; Methyltransferases; Mice; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1992 |
In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; DNA; DNA Repair; Doxorubicin; Female; Guanine; Hodgkin Disease; Humans; Injections, Intravenous; Leukocytes; Lymphoma, Non-Hodgkin; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Pilot Projects; Rats; Rats, Inbred Strains; Vinblastine; Vincristine | 1991 |
Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Chlorambucil; Colonic Neoplasms; Dacarbazine; DNA Repair; Dose-Response Relationship, Drug; Guanine; Humans; Imidazoles; Kinetics; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Methyltransferases; Mice; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide | 1987 |
Accumulation of O6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects.
Topics: Animals; Dacarbazine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Guanine; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Procarbazine; Rats; Species Specificity | 1993 |
Comparative study of the formation and repair of O6-methylguanine in humans and rodents treated with dacarbazine.
Topics: Animals; Dacarbazine; DNA Damage; DNA Repair; Female; Guanine; Hodgkin Disease; Humans; Male; Methyltransferases; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity | 1996 |
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Dacarbazine; DNA Glycosylases; Erythrocytes; Ethylnitrosourea; Female; Fibroblasts; Guanine; Hypoxanthine Phosphoribosyltransferase; Leukocyte Count; Liver; Male; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mutagens; Mutation; N-Glycosyl Hydrolases; Temozolomide | 1998 |
Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; DNA Adducts; DNA Repair; Female; Guanine; Humans; Hydroxyurea; Hypoxanthine Phosphoribosyltransferase; Leukocytes; Male; Melanoma; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1996 |
Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzamides; Dacarbazine; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Jurkat Cells; Leukemia; N-Glycosyl Hydrolases; Poly(ADP-ribose) Polymerase Inhibitors; RNA, Messenger; Temozolomide; Transcription, Genetic; Triazenes | 1999 |
Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Guanine; Humans; Male; Melanoma, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous | 2000 |
Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase.
Topics: Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Dacarbazine; DNA Methylation; DNA Mutational Analysis; Enzyme Induction; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Liver Extracts; Male; Methylnitrosourea; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Rats, Sprague-Dawley | 2000 |
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Division; Dacarbazine; DNA Damage; DNA Replication; fas Receptor; Gamma Rays; Gene Expression Regulation; Guanine; Humans; Lymphocytes; Methylnitronitrosoguanidine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Temozolomide; Tumor Suppressor Protein p53 | 2004 |
Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.
Topics: Animals; Antigens, Differentiation; Antineoplastic Agents, Alkylating; Cell Cycle Proteins; Cell Line, Tumor; Comet Assay; Dacarbazine; DNA Damage; DNA Repair; Drug Synergism; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Oncolytic Viruses; Plasmids; Protein Phosphatase 1; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotide Reductases; RNA, Small Interfering; Simplexvirus; Temozolomide; Transcription, Genetic; Transfection; Transplantation, Heterologous | 2006 |
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Caspases; Cell Cycle; Cell Proliferation; Dacarbazine; DNA Breaks, Double-Stranded; DNA Damage; Fas Ligand Protein; Fas-Associated Death Domain Protein; Flow Cytometry; Glioma; Guanine; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2007 |
Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; DNA Damage; Guanine; Humans; Luciferases; Microscopy, Fluorescence; NF-kappa B; Protein Binding; Subcellular Fractions; Temozolomide; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor RelA | 2007 |
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Cell Nucleus; Cell Proliferation; Cell Survival; Cycloheximide; Dacarbazine; Drug Resistance, Neoplasm; Enzyme Stability; Gene Expression Regulation, Neoplastic; Glioma; Green Fluorescent Proteins; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2009 |
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.
Topics: Animals; Apoptosis; BRCA2 Protein; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; Dacarbazine; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Down-Regulation; Fluorescent Antibody Technique; Guanine; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Sister Chromatid Exchange; Temozolomide; Transfection | 2009 |
Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.
Topics: Cell Division; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Mismatch Repair; Drug Resistance, Neoplasm; Enzyme Activation; G2 Phase; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Radiation Dosage; Radiation Tolerance; Temozolomide | 2009 |
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Guanine; Humans; Hydrazines; Mice; O(6)-Methylguanine-DNA Methyltransferase; Sulfonamides; Temozolomide | 2010 |
Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Caspase 7; Cell Cycle Proteins; Cell Line, Transformed; Cell Line, Tumor; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Fibroblasts; Guanine; Homozygote; Humans; Melanoma; Methylnitronitrosoguanidine; Mutagens; Mutation; Necrosis; Nijmegen Breakage Syndrome; Nuclear Proteins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Temozolomide; Uveal Neoplasms | 2010 |
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mechanistic Target of Rapamycin Complex 1; Methylnitronitrosoguanidine; Multiprotein Complexes; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2010 |
Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Dacarbazine; Female; Guanine; Humans; Irinotecan; Mice; Mice, Nude; Neuroblastoma; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Xenograft Model Antitumor Assays | 2010 |
Temozolomide: mechanisms of action, repair and resistance.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Central Nervous System Neoplasms; Dacarbazine; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-(Apurinic or Apyrimidinic Site) Lyase; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide; Tumor Suppressor Proteins | 2012 |
Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Autophagy; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Cellular Senescence; Dacarbazine; DNA Damage; DNA Mismatch Repair; DNA Modification Methylases; DNA-Binding Proteins; Glioma; Guanine; Homologous Recombination; Humans; Protein Serine-Threonine Kinases; Temozolomide; Tumor Suppressor Proteins | 2013 |
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.
Topics: Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Melanoma; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinases; Signal Transduction; Temozolomide; Tumor Suppressor Proteins | 2013 |
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glutathione; Guanine; HCT116 Cells; Humans; Male; Mice, Inbred BALB C; Molecular Targeted Therapy; Temozolomide; Thioctic Acid; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide.
Topics: Antineoplastic Agents, Alkylating; Bone Morphogenetic Protein 7; Cell Proliferation; Cell Survival; Dacarbazine; DNA Modification Methylases; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Neoplastic Stem Cells; Temozolomide; Tumor Cells, Cultured | 2015 |
Glioblastomas with IDH1/2 mutations have a short clinical history and have a favorable clinical outcome.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Dacarbazine; DNA Methylation; Female; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Japan; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Mutation; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Temozolomide | 2016 |
DNA-Targeted Inhibition of MGMT.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; DNA; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Guanine; Humans; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2017 |
A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; Cricetulus; Dacarbazine; DNA Repair; DNA, Neoplasm; Guanine; Humans; Mutation; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide | 2017 |
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Transcriptional control of O
Topics: Antineoplastic Agents, Alkylating; Dacarbazine; DNA; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Temozolomide | 2018 |
PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Guanine; Humans; Mice; Poly ADP Ribosylation; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Proteins | 2021 |
KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.
Topics: Alkylating Agents; Dacarbazine; DNA; DNA Repair; Epigenesis, Genetic; Guanine; O(6)-Methylguanine-DNA Methyltransferase; Parthanatos; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide | 2022 |
The Impact of O6-Methylguanine-DNA Methyltransferase (
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Humans; Leiomyosarcoma; Methyltransferases; Middle Aged; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2023 |