o(6)-methyl-2'-deoxyguanosine has been researched along with deoxyguanosine in 73 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 21 (28.77) | 18.7374 |
1990's | 30 (41.10) | 18.2507 |
2000's | 13 (17.81) | 29.6817 |
2010's | 8 (10.96) | 24.3611 |
2020's | 1 (1.37) | 2.80 |
Authors | Studies |
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Chen, J; Hall, J; Han, C; Hu, G; Wild, CP | 1 |
Dominé, F; Kleihues, P; Ludeke, BI; Ohgaki, H | 1 |
Aboul-Azm, T; Badawi, AF; Cooper, DP; Haboubi, NY; Mostafa, MH; O'Connor, PJ | 1 |
Cooper, DP; Howell, A; Laidlaw, I; O'Connor, PJ; Potten, CS; Zaidi, SN | 1 |
Kleihues, P; Ludeke, BI; Weller, RO; Yamada, Y | 1 |
Chae, WG; Chang, CJ; Cooks, RG; Wood, JM | 1 |
Devor, D; Kaufman, DG; Kaufmann, WK; MacKenzie, SA; Qaqish, BF; Rice, JM; Smith, GJ; Wenk, ML | 1 |
Kleihues, P; Ludeke, BI; Lutz, WK; Meier, I; Ohgaki, H; Schlatter, C | 1 |
Itano, K; Kawazoe, Y; Kohda, K; Sawada, N; Yasuda, M | 1 |
Bartsch, H; Béréziat, JC; Camus, AM; Hietanen, E; Montesano, R; Shuker, DE; Wild, CP | 1 |
Alvi, NK; Foiles, PG; Williams, GM | 1 |
Dirsch, OR; Kleihues, P; Koenigsmann, M; Ludeke, BI; Scherer, E | 1 |
Adamkiewicz, J; Kan, LS; Rajewsky, MF; Senear, DF; Ts'o, PO; Yuhasz, SC | 1 |
Boucheron, JA; Richardson, FC; Skopek, TR; Swenberg, JA | 1 |
Wang, JJ | 1 |
Myers, KA; O'Connor, PJ; Saffhill, R | 1 |
Basu, AK; Essigmann, JM; Harris, CC; Smith, RA; Wilson, VL | 1 |
Beland, FA; Delongchamp, RR; Dooley, KL; Sheldon, WG | 1 |
Akerkar, SA; Everson, RB; Foiles, PG; Hecht, SS; Miglietta, LM | 1 |
Jeltsch, W; Kleihues, P; Koenigsmann, M; Ludeke, B; Schmerold, I; Wiessler, M | 1 |
Feng, L; Lu, SX; Luo, FQ; Tian, YA; Zhang, MS | 1 |
Feng, L; Lu, SX | 1 |
Chapot, B; Montesano, R; Umbenhauer, D; Wild, CP | 1 |
Castonguay, A; Foiles, PG; Trushin, N | 1 |
Boyle, JM; Huh, N; Kirstein, U; Lu, SH; Montesano, R; Rajewsky, MF; Saffhill, R; Thomale, J; Umbenhauer, D; Wild, CP | 1 |
Castonguay, A; Foiles, PG; Hecht, SS; Trushin, N | 1 |
Boyle, JM; Saffhill, R; Smart, G; Wild, CP | 1 |
Ball, JC; Maher, VM; McCormick, JJ | 1 |
Ayres, K; Larson, K; Lindgren, V; Sklar, R; Strauss, B | 1 |
Abbott, PJ; Ludlum, DB; Mehta, JR | 1 |
Foote, RS; Mitra, S; Pal, BC | 1 |
Salih, H; Swann, PF | 1 |
Kyrtopoulos, SA; Vrotsou, B | 1 |
Cooper, DP; Povey, AC | 1 |
O'Connor, PJ; Zaidi, NH | 1 |
Ito, N; Montesano, R; Ogawa, K; Shibata, MA; Shirai, T; Takahashi, S; Tsuda, H; Wild, CP | 1 |
Cooper, DP; Crowther, D; Lee, SM; Margison, GP; O'Connor, PJ; Thatcher, N | 1 |
Cooper, DP; Lee, SM; Margison, GP; O'Connor, PJ; Thatcher, N | 1 |
Cooper, DP; Margison, GP; O'Connor, PJ; Potten, CS; Zaidi, NH | 2 |
Bowman, ED; Cooper, DP; Kato, S; Petruzzelli, S; Povey, AC; Shields, PG; Weston, A | 1 |
Asamoto, M; Iwase, T; Kato, T; Matsumoto, K; Montesano, R; Nagao, S; Ozaki, K; Tsuda, H; Wild, CP | 1 |
Awney, HA; Badawi, AF; Mostafa, MH | 1 |
Fukushima, S; Kurata, Y; Mizoguchi, M; Montesano, R; Naito, H; Shibata, MA; Tsuda, H; Wild, CP | 1 |
Badawi, AF; Cooper, DP; Cooper, R; Doenhoff, MJ; Fallon, P; Mostafa, MH; O'Connor, PJ; Probert, A | 1 |
Jain, R; Sharma, M | 1 |
Bakhmedova, AA; Dederer, LIu; Gorbacheva, LB; Mel'nik, SIa; Miniker, TD; Sokolova, IS | 1 |
Encell, L; Foiles, PG; Gold, B | 1 |
Foiles, PG; Hecht, SS; Miglietta, LM; Staretz, ME | 1 |
Demopoulos, NA; Stephanou, G; Vlachodimitropoulos, D; Vlastos, D | 1 |
Cooper, DP; Harrison, KL; Jukes, R; Shuker, DE | 1 |
Badawi, AF; Cooper, DP; Hall, CN; O'Connor, PJ; Povey, AC | 1 |
Nikolic, D; Swanson, SM; van Breemen, RB; Yang, Y | 1 |
Mirvish, SS; Zhou, L | 1 |
Eckert, KA; Hamid, S | 1 |
Fang, Q; Kanugula, S; Pegg, AE | 1 |
Brink, A; Lutz, U; Lutz, WK; Völkel, W | 1 |
Brown, K; Dingley, K; Farmer, PB; Jukes, R; Lamb, JH; Martin, EA; Tompkins, EM; Turteltaub, KW; Ubick, E | 1 |
Fang, Q; Guza, R; Pegg, AE; Rajesh, M; Tretyakova, N | 1 |
Burns, PA; Gottschalg, E; Scott, GB; Shuker, DE | 1 |
Beland, FA; Churchwell, MI; Doerge, DR | 1 |
Brown, K; Farmer, PB; Jones, DJ; Lamb, JH; McLuckie, KI; Pearson, HL; Sandhu, JK | 1 |
Brink, A; Lutz, WK; Schulz, B; Stopper, H | 1 |
Adema, AD; Honeywell, RJ; Peters, GJ; van der Born, K | 1 |
Clarke, JM; Cosgrove, LJ; Gerber, JP; Head, RJ; Lockett, TJ; Tan, SL; Williams, DB | 1 |
Bird, AR; Conlon, MA; Hu, Y; Le Leu, RK; Nyskohus, L; Topping, DL; Winter, J; Young, GP | 1 |
Jitsuzaki, D; Li, Z; Nishioka, T; Onizuka, K; Sasaki, S; Taniguchi, Y | 1 |
Khaira, A; McManus, FP; Noronha, AM; Wilds, CJ | 1 |
Da Pieve, C; Moore, SA; Sahgal, N; Velasco-Garcia, MN | 1 |
Clement, JM; Collins, LB; Nakamura, J; Sharma, V; Swenberg, JA; Zhang, Z | 1 |
Bird, AR; Christophersen, CT; Conlon, MA; Gratz, SW; Hu, Y; Humphreys, KJ; Le Leu, RK; Miller, RB; Topping, DL; Winter, JM; Young, GP | 1 |
Gowda, AS; Spratt, TE | 1 |
Egli, M; Kellum, AH; Nilforoushan, A; Pallan, PS; Stone, MP; Sturla, SJ | 1 |
1 trial(s) available for o(6)-methyl-2'-deoxyguanosine and deoxyguanosine
Article | Year |
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Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial.
Topics: Amylose; Animals; Bacteroides; Cattle; Clostridium; Colon; Cooking; Cross-Over Studies; Deoxyguanosine; Diet; Diet Records; DNA Adducts; Double-Blind Method; Energy Intake; Escherichia coli; Feces; Female; Humans; Lactobacillus; Male; Meat; Microbiota; Middle Aged; Ruminococcus; Starch; Zea mays | 2015 |
72 other study(ies) available for o(6)-methyl-2'-deoxyguanosine and deoxyguanosine
Article | Year |
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Lack of effects of selenium on N-nitrosomethylbenzylamine-induced tumorigenesis, DNA methylation, and oncogene expression in rats and mice.
Topics: Animals; Biological Assay; Carcinogens; Deoxyguanosine; Dimethylnitrosamine; DNA, Neoplasm; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Genes, myc; Male; Methylation; Methyltransferases; Mice; Mice, Inbred Strains; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Wistar; Selenium; Stomach Neoplasms | 1992 |
Modulation of N-nitrosomethylbenzylamine bioactivation by diallyl sulfide in vivo.
Topics: Allyl Compounds; Animals; Antineoplastic Agents; Biotransformation; Carcinogens; Deoxyguanosine; Dimethylnitrosamine; DNA; Esophagus; Garlic; Liver; Lung; Male; Methylation; Olfactory Mucosa; Plants, Medicinal; Rats; Rats, Inbred F344; Sulfides | 1992 |
Promutagenic methylation damage in bladder DNA from patients with bladder cancer associated with schistosomiasis and from normal individuals.
Topics: Age Factors; Deoxyguanosine; DNA Damage; DNA, Neoplasm; Egypt; Female; Humans; Male; Methylation; Schistosomiasis haematobia; Sex Factors; Urinary Bladder Neoplasms | 1992 |
Normal human breast xenografts activate N-nitrosodimethylamine: identification of potential target cells for an environmental nitrosamine.
Topics: Animals; Biotransformation; Breast; Deoxyguanosine; Dimethylnitrosamine; DNA; Drug Implants; Estradiol; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Transplantation, Heterologous | 1992 |
Effects of ethanol and various alcoholic beverages on the formation of O6-methyldeoxyguanosine from concurrently administered N-nitrosomethylbenzylamine in rats: a dose-response study.
Topics: Alcoholic Beverages; Animals; Biotransformation; Carcinogens; Cell Nucleus; Deoxyguanosine; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Esophagus; Ethanol; Liver; Male; Methylation; Rats; Rats, Inbred F344 | 1992 |
Chemical modification of DNA: quantitation of O6-methyldeoxyguanosine by tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; Mass Spectrometry | 1991 |
Proliferation of carcinogen-damaged hepatocytes during cell-cycle-dependent initiation of hepatocarcinogenesis in the rat.
Topics: Animals; Carcinogens; Cell Cycle; Cocarcinogenesis; Deoxyguanosine; Dimethylnitrosamine; DNA Damage; DNA Repair; Guanine; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Rats; Rats, Inbred F344 | 1991 |
DNA methylation in the digestive tract of F344 rats during chronic exposure to N-methyl-N-nitrosourea.
Topics: Administration, Oral; Animals; Bromodeoxyuridine; Cell Division; Deoxyguanosine; Digestive System; DNA; DNA Damage; Epithelium; Esophagus; Hyperplasia; Immunoblotting; Male; Methylation; Methylnitrosourea; Purines; Rats; Rats, Inbred F344 | 1991 |
Dealkylation rates of O6-alkyldeoxyguanosine, O4-alkylthymidine and related compounds in an alkyl-transfer system.
Topics: Alkylation; Benzene Derivatives; Carbon Isotopes; Deoxyguanosine; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Organoselenium Compounds; Selenium; Thymidine | 1991 |
Effects of a high fat diet on liver DNA methylation in rats exposed to N-nitrosodimethylamine.
Topics: Animals; Deoxyguanosine; Dietary Fats; Dimethylnitrosamine; DNA; Liver; Male; Methylation; Rats; Rats, Inbred Strains | 1990 |
Inhibition of repair of O6-methyldeoxyguanosine and enhanced mutagenesis in rat-liver epithelial cells.
Topics: Alkyl and Aryl Transferases; Animals; Cells, Cultured; Deoxyguanosine; DNA; DNA Repair; Epithelial Cells; Epithelium; Kinetics; Liver; Male; Methylnitronitrosoguanidine; Mutation; Rats; Rats, Inbred F344; Transferases | 1990 |
Bioactivation of N-nitrosomethylbenzylamine and N-nitrosomethyl-amylamine in oesophageal papillomas.
Topics: Animals; Autoradiography; Biotransformation; Carbon Radioisotopes; Carcinogens; Deoxyguanosine; Dimethylnitrosamine; Esophageal Neoplasms; Male; Nitrosamines; Papilloma; Rats; Rats, Inbred F344 | 1990 |
Thermodynamic investigation of monoclonal antibody alkylated nucleoside interaction as a model for epitope recognition on nucleic acids.
Topics: Alkylation; Animals; Antibodies, Monoclonal; Deoxyguanosine; DNA; Epitopes; Kinetics; Mice; Mice, Inbred BALB C; Models, Biological; Thermodynamics | 1987 |
Formation of O6-methyldeoxyguanosine at specific sites in a synthetic oligonucleotide designed to resemble a known mutagenic hotspot.
Topics: Alkylation; Deoxyguanosine; Escherichia coli; Genes; Genes, Bacterial; Indicators and Reagents; Methylnitrosourea; Mutation; Oligodeoxyribonucleotides; Pentosyltransferases | 1989 |
[O6-mdGuo demethylation in cells and tissues].
Topics: Deoxyguanine Nucleotides; Deoxyguanosine; HeLa Cells; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oxidoreductases; Oxidoreductases, O-Demethylating; Substrate Specificity | 1988 |
Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat.
Topics: Acid Phosphatase; Alkylation; Animals; Carcinogens; Cell Nucleus; Deoxyguanosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; DNA, Mitochondrial; Guanosine; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1988 |
O6-alkyldeoxyguanosine detection by 32P-postlabeling and nucleotide chromatographic analysis.
Topics: Alkylation; Animals; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; Liver; Male; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains | 1988 |
Circadian variation in the induction of intestinal tumors by N-methyl-N-nitrosourea in male C57BL/6N mice.
Topics: Adenocarcinoma; Animals; Circadian Rhythm; Deoxyguanosine; DNA; Intestinal Neoplasms; Intestine, Small; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL | 1988 |
Detection of O6-methyldeoxyguanosine in human placental DNA.
Topics: Antibodies, Monoclonal; Deoxyguanosine; DNA; Enzyme-Linked Immunosorbent Assay; Female; Humans; Placenta; Smoking | 1988 |
Organ and cell specificity of DNA methylation by N-nitrosomethylamylamine in rats.
Topics: Animals; Autoradiography; Biotransformation; Deoxyguanosine; DNA; Immunohistochemistry; Male; Methylation; Nitrosamines; Organ Specificity; Rats; Rats, Inbred F344 | 1988 |
[O6-methyldeoxyguanosine in DNA of the adjacent epithelium in human esophageal cancer in Linxian County].
Topics: Cardia; China; Deoxyguanosine; DNA, Neoplasm; Epithelium; Esophageal Neoplasms; Esophagus; Humans; Stomach Neoplasms | 1986 |
[Modification of esophageal epithelium DNA in the human fetus by N-nitrosomethylbenzylamine (NMBzA)].
Topics: Carcinogens; Deoxyguanosine; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Epithelium; Esophagus; Fetus; Humans | 1987 |
Monitoring of individual human exposure to aflatoxins (AF) and N-nitrosamines (NNO) by immunoassays.
Topics: Aflatoxins; Carcinogens; China; Deoxyguanosine; Digestive System Neoplasms; DNA; DNA Repair; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Europe; Humans; Mass Screening; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Philippines | 1986 |
Measurement of O6-methyldeoxyguanosine in DNA methylated by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone using a biotin-avidin enzyme-linked immunosorbent assay.
Topics: Animals; Avidin; Biotin; Cattle; Cells, Cultured; Deoxyguanosine; DNA; Enzyme-Linked Immunosorbent Assay; Methylation; Methylnitrosourea; Nasal Mucosa; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Thymus Gland; Tissue Distribution | 1985 |
O(6)-methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer.
Topics: China; Deoxyguanosine; DNA; Esophageal Neoplasms; Esophagus; France; Gastric Mucosa; Germany; Humans; Methyltransferases; Mucous Membrane; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Radioimmunoassay; Risk | 1985 |
Study of DNA methylation by tobacco-specific N-nitrosamines.
Topics: Animals; Antibodies; Carcinogens; Cells, Cultured; Deoxyguanosine; Deoxyribonucleosides; DNA; Enzyme-Linked Immunosorbent Assay; Methylation; Mucous Membrane; Nasal Mucosa; Neoplasms, Experimental; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Smoking | 1985 |
Radioimmunoassay of O6-methyldeoxyguanosine in DNA of cells alkylated in vitro and in vivo.
Topics: Alkylation; Animals; Antibodies; Antibodies, Monoclonal; Antigen-Antibody Complex; Cattle; Deoxyguanosine; DNA; Kidney; Liver; Lymphocytes; Methylnitrosourea; Mice; Plasmacytoma; Radioimmunoassay; Rats; Thymus Gland | 1983 |
Biological effects of incorporation of O6-methyldeoxyguanosine into Chinese hamster V79 cells.
Topics: Adenosine Deaminase Inhibitors; Animals; Cell Line; Cell Survival; Coformycin; Cricetinae; Cricetulus; Deoxyguanosine; DNA Replication; Female; Ovary | 1983 |
Regulation of the capacity for O6-methylguanine removal from DNA in human lymphoblastoid cells studied by cell hybridization.
Topics: Adenosine; Cell Fusion; Cell Line; Deoxyguanosine; DNA; Drug Resistance; Female; Humans; Hybrid Cells; Karyotyping; Lymphoma; Male; Methylnitronitrosoguanidine; Neoplasms, Experimental | 1982 |
Synthesis of 8-14C-labeled O6-methyldeoxyguanosine and its deoxynucleotide copolymers.
Topics: Deoxyguanine Nucleotides; Deoxyguanosine; DNA Polymerase I; Drug Stability; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Methods; Poly C; Poly T; Polydeoxyribonucleotides; Polyribonucleotides; Structure-Activity Relationship; Substrate Specificity | 1980 |
Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli.
Topics: Deoxyguanosine; Enzyme Induction; Escherichia coli; Guanine; Kinetics; Methylnitronitrosoguanidine; Polydeoxyribonucleotides | 1980 |
Immunoassay of O6-methyldeoxyguanosine in DNA: the use of polyethylene glycol to separate bound and free nucleoside.
Topics: Alkylation; Animals; Antibody Specificity; Cross Reactions; Deoxyguanosine; Dimethylnitrosamine; DNA; Immune Sera; Liver; Male; Polyethylene Glycols; Radioimmunoassay; Rats | 1982 |
The formation and repair of O6-methylguanine in rat liver nucleolar DNA after dimethylnitrosamine administration studied by radioimmunoassay.
Topics: Animals; Cell Nucleolus; Deoxyguanosine; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Radioimmunoassay; Rats; Rats, Inbred Strains | 1981 |
The development, validation and application of a 32P-postlabelling assay to quantify O6-methylguanine in human DNA.
Topics: Chromatography, Thin Layer; Deoxyguanosine; DNA; DNA Damage; Female; Guanine; Humans; Isotope Labeling; Male; Nucleotides; Phosphorus Radioisotopes; Reproducibility of Results | 1995 |
Identification in rat stomach mucosae of a cell population characterized by a deficiency for the repair of O6-methyldeoxyguanosine from DNA.
Topics: Animals; Carcinogens; Deoxyguanosine; DNA; DNA Repair; Duodenum; Gastric Mucosa; Immunohistochemistry; Male; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rats, Wistar | 1995 |
DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
Topics: Administration, Oral; Animals; Base Sequence; Butylhydroxybutylnitrosamine; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Deoxyguanosine; Disease Progression; DNA Adducts; DNA Damage; DNA Mutational Analysis; DNA, Neoplasm; Genes, ras; Injections, Intraperitoneal; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Neoplasm Invasiveness; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1994 |
Relationships between the formation of O6-methyldeoxyguanosine by 1-p-carboxyl-3,3-dimethylphenyltriazene in DNA and O6-alkylguanine-DNA alkyltransferase in human peripheral leukocytes.
Topics: Adult; Aged; Antineoplastic Agents; Deoxyguanosine; DNA Nucleotidyltransferases; DNA, Neoplasm; Female; Guanine; Humans; Leukocytes; Lymphocytes; Male; Melanoma; Middle Aged; Triazenes | 1994 |
Formation and loss of O6-methyldeoxyguanosine in human leucocyte DNA following sequential DTIC and fotemustine chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Deoxyguanosine; DNA; Female; Humans; Leukocytes; Lymphocytes; Male; Middle Aged; Nitrosourea Compounds; Nucleotidyltransferases; Organophosphorus Compounds | 1994 |
Tissue and cell specific methylation, repair and synthesis of DNA in the upper gastrointestinal tract of Wistar rats treated with single doses of N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Cell Division; Deoxyguanosine; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Duodenum; Esophagus; Gastric Mucosa; Male; Methylation; Methylnitronitrosoguanidine; Methyltransferases; Pylorus; Rats; Rats, Wistar; Stomach | 1993 |
Tissue and cell specific methylation, repair and synthesis of DNA in the upper gastrointestinal tract of Wistar rats treated with N-methyl-N'-nitro-N-nitrosoguanidine via the drinking water.
Topics: Animals; Deoxyguanosine; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Duodenum; Esophagus; Gastric Mucosa; Jejunum; Male; Methylation; Methylnitronitrosoguanidine; Methyltransferases; Pylorus; Rats; Rats, Wistar; Stomach; Water Supply | 1993 |
Combined micropreparative techniques with synchronous fluorescence spectroscopy or 32P-postlabelling assay for carcinogen-DNA adduct determination.
Topics: Benzo(a)pyrene; Carcinogens; Chromatography, Affinity; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; Humans; In Vitro Techniques; Lung; Methods; Phosphorus Radioisotopes; Polycyclic Compounds; Reference Standards; Spectrometry, Fluorescence | 1993 |
Decreased dimethylnitrosamine-induced O6- and N7-methyldeoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Deoxyguanosine; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Glutathione Transferase; Immunohistochemistry; Liver Neoplasms; Male; Neoplasm Transplantation; Rats; Rats, Inbred F344 | 1993 |
Formation of promutagenic methylation damage in tissue-DNA of mice treated with antischistosomal agents.
Topics: Alkylation; Animals; Deoxyguanosine; DNA; DNA Damage; Hycanthone; Kidney; Liver; Male; Methylation; Mice; Mice, Inbred Strains; Oxamniquine; Schistosomicides; Spleen; Trichlorfon; Urinary Bladder | 1993 |
Influence of aging on multi-organ carcinogenesis in rats induced by N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Aging; Animals; Bromodeoxyuridine; Deoxyguanosine; DNA; Intestinal Neoplasms; Lymphoma; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Splenic Neoplasms; Thymus Neoplasms; Tongue Neoplasms | 1993 |
Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni.
Topics: Animals; Deoxyguanosine; DNA; DNA Damage; Female; Liver; Male; Methylation; Mice; Mutation; Schistosoma mansoni; Schistosomiasis mansoni; Sex Factors | 1993 |
Fluorescence postlabeling assay of DNA damage induced by N-methyl-N-nitrosourea.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Damage; Fluorescence; Magnetic Resonance Spectroscopy; Methylnitrosourea | 1993 |
[Modulation of the antitumor activity of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoure a by O(6)-methyl-2'-deoxyguanosine--a new inhibitor of O(6)-alkylguanine-DNA-alkyltransferase].
Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyguanosine; DNA-Directed DNA Polymerase; Drug Resistance, Neoplasm; Drug Synergism; Leukemia L1210; Melanoma, Experimental; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1995 |
The relationship between N-nitrosodimethylamine metabolism and DNA methylation in isolated rat hepatocytes.
Topics: Animals; Carcinogens; Deoxyguanosine; Dimethylnitrosamine; DNA; Liver; Male; Methylation; Rats; Rats, Sprague-Dawley | 1996 |
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Isothiocyanates; Lung; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
A comparative study on the effect of MNU on human lymphocyte cultures in vitro evaluated by O6-mdG formation, micronuclei and sister chromatid exchanges induction.
Topics: Carcinogens; Cells, Cultured; Deoxyguanosine; Humans; Lymphocytes; Methylnitrosourea; Micronucleus Tests; Sister Chromatid Exchange | 1996 |
Detection of concomitant formation of O6-carboxymethyl- and O6-methyl-2'-deoxyguanosine in DNA exposed to nitrosated glycine derivatives using a combined immunoaffinity/HPLC method.
Topics: Animals; Calibration; Carcinogens; Cattle; Chromatography, Affinity; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; Glycine; Immunosorbents; Nitroso Compounds; Thymus Gland | 1999 |
Elevated levels of the pro-carcinogenic adduct, O(6)-methylguanine, in normal DNA from the cancer prone regions of the large bowel.
Topics: Aged; Alkylation; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxyguanosine; DNA Adducts; Female; Humans; Male; Radioimmunoassay | 2000 |
Quantitative determination of N7-methyldeoxyguanosine and O6-methyldeoxyguanosine in DNA by LC-UV-MS-MS.
Topics: Animals; Cattle; Chromatography, Liquid; Deoxyguanosine; DNA; DNA Adducts; Hydrolysis; Indicators and Reagents; Liver; Mass Spectrometry; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 2002 |
Inhibition by allyl sulfides and crushed garlic of O6-methylguanine formation in liver DNA of dimethylnitrosamine-treated rats.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Chromatography, High Pressure Liquid; Deoxyguanosine; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Garlic; Kidney; Liver; Lung; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfides | 2005 |
Effect of DNA polymerase beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate.
Topics: Alkylating Agents; Amino Acid Substitution; Animals; Arginine; Base Sequence; Deoxycytosine Nucleotides; Deoxyguanosine; DNA Damage; DNA Polymerase beta; DNA Primers; Glutamic Acid; Lysine; Methionine; Methylnitrosourea; Molecular Sequence Data; Protein Structure, Tertiary; Rats; Substrate Specificity; Templates, Genetic; Thymine Nucleotides | 2005 |
Function of domains of human O6-alkylguanine-DNA alkyltransferase.
Topics: Deoxyguanosine; DNA Repair; Escherichia coli; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Protein Folding; Protein Renaturation; Protein Structure, Tertiary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2005 |
Simultaneous determination of O6-methyl-2'-deoxyguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, and 1,N6-etheno-2'-deoxyadenosine in DNA using on-line sample preparation by HPLC column switching coupled to ESI-MS/MS.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxyguanosine; DNA; DNA Adducts; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2006 |
A novel 14C-postlabeling assay using accelerator mass spectrometry for the detection of O6-methyldeoxy-guanosine adducts.
Topics: Acetic Anhydrides; Carbon Radioisotopes; Deoxyguanosine; DNA Adducts; Environmental Monitoring; Humans; Mass Spectrometry; Particle Accelerators | 2006 |
Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences.
Topics: Base Sequence; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Primers; DNA Repair; Genes, ras; Humans; Kinetics; O(6)-Methylguanine-DNA Methyltransferase; Spectrometry, Mass, Electrospray Ionization | 2006 |
Potassium diazoacetate-induced p53 mutations in vitro in relation to formation of O6-carboxymethyl- and O6-methyl-2'-deoxyguanosine DNA adducts: relevance for gastrointestinal cancer.
Topics: Azo Compounds; Chromatography, Affinity; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; Gastrointestinal Neoplasms; Genes, p53; Glycine; Humans; Mutation; Plasmids | 2007 |
Quantification of O6-methyl and O6-ethyl deoxyguanosine adducts in C57BL/6N/Tk+/- mice using LC/MS/MS.
Topics: Animals; Deoxyguanosine; Female; Liver; Male; Mice; Mice, Inbred C57BL; Reference Standards; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2006 |
Development of a novel site-specific mutagenesis assay using MALDI-ToF MS (SSMA-MS).
Topics: Cell Line; Deoxyguanosine; DNA Adducts; Escherichia coli; Genetic Vectors; Humans; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Plasmids; Reference Standards; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transfection | 2006 |
Biological significance of DNA adducts investigated by simultaneous analysis of different endpoints of genotoxicity in L5178Y mouse lymphoma cells treated with methyl methanesulfonate.
Topics: Animals; Cell Line, Tumor; Chromatography, Liquid; Deoxyguanosine; DNA Adducts; DNA Breaks; DNA Methylation; Dose-Response Relationship, Drug; Guanine; Leukemia L5178; Methyl Methanesulfonate; Mice; Models, Biological; Mutagens; Tandem Mass Spectrometry | 2007 |
Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines.
Topics: Animals; Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Dacarbazine; Deoxycytidine; Deoxyguanosine; DNA Adducts; DNA Methylation; Drug Synergism; Gemcitabine; Humans; Lung Neoplasms; Mice; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Piperidines; Pyridines; Temozolomide | 2009 |
Is the tissue persistence of O(6)-methyl-2'-deoxyguanosine an indicator of tumour formation in the gastrointestinal tract?
Topics: Alkylating Agents; Animals; Azoxymethane; Colonic Neoplasms; Deoxyguanosine; DNA Adducts; Gastrointestinal Tract; Intestinal Neoplasms; Intestine, Small; Male; Methylation; Mutagens; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon.
Topics: Animals; Apoptosis; Cell Proliferation; Colon; Deoxyguanosine; Dietary Carbohydrates; Dietary Proteins; DNA Adducts; Feces; Fermentation; Intestine, Large; Male; Meat; Mice; Mice, Inbred C57BL; Mutagens; Starch | 2011 |
An efficient and simple method for site-selective modification of O6-methyl-2'-deoxyguanosine in DNA.
Topics: Base Sequence; Binding Sites; Deoxyguanosine; DNA; Substrate Specificity | 2012 |
Preparation of covalently linked complexes between DNA and O(6)-alkylguanine-DNA alkyltransferase using interstrand cross-linked DNA.
Topics: Base Sequence; Cross-Linking Reagents; Deoxyguanosine; DNA; DNA Repair; Escherichia coli; Humans; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; O(6)-Methylguanine-DNA Methyltransferase | 2013 |
Development of a liquid chromatography/tandem mass spectrometry method to investigate the presence of biomarkers of DNA damage in urine related to red meat consumption and risk of colorectal cancer.
Topics: Animals; Chromatography, Liquid; Colorectal Neoplasms; Cross-Over Studies; Deoxyguanosine; Diet; Diet, Vegetarian; DNA Damage; Guanine; Humans; Limit of Detection; Meat; Tandem Mass Spectrometry | 2013 |
Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells.
Topics: Cells, Cultured; Deoxyguanosine; Dose-Response Relationship, Drug; Guanine; Humans; Methylnitrosourea | 2014 |
DNA Polymerase ν Rapidly Bypasses O
Topics: Deoxyguanosine; DNA-Directed DNA Polymerase; Escherichia coli Proteins; Kinetics; Thymidine | 2016 |
Conformation and Pairing Properties of an
Topics: Benzimidazoles; Carcinogens; Deoxyguanosine; DNA; DNA Adducts; Nucleic Acid Conformation; Nucleosides; Nucleotides; S-Adenosylmethionine; Xenobiotics | 2022 |