o(6)-benzylguanine has been researched along with methylnitronitrosoguanidine in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (58.82) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dolan, ME; Moschel, RC; Mummert, C; Pegg, AE; Stine, L; Wiest, L | 1 |
| Crone, TM; Pegg, AE | 1 |
| Furusho, K; Gerson, SL; Kubota, M; Liu, L; Wakazono, Y | 1 |
| Bhattacharyya, NP; Maher, VM; McCormick, JJ; Tsujimura, T; Zhang, H | 1 |
| Armstrong, MJ; Galloway, SM | 1 |
| Christians, FC; Coates, MM; Dawson, BJ; Loeb, LA | 1 |
| Berger, MS; Blank, A; Bobola, MS; Silber, JR; Tseng, SH | 1 |
| Aquilina, G; Bignami, M; Branch, P; Fiumicino, S; Humbert, O; Karran, P; Oda, S; Zijno, A | 1 |
| Arends, MJ; Clarke, AR; Dekker, M; Howard, LA; Kelly, J; Margison, GP; te Riele, H; Toft, NJ; Winton, DJ; Wyllie, AH | 1 |
| Kooistra, R; Lohman, PH; Margison, GP; Pastink, A; Watson, AJ; Zonneveld, JB | 1 |
| Pegg, AE; Xu-Welliver, M | 1 |
| Crone, TM; Kanugula, S; Loktionova, NA; Pegg, AE; Xu-Welliver, M | 1 |
| Encell, LP; Loeb, LA | 1 |
| Asaumi, J; Fukui, K; Kawai, N; Kishi, K; Kokeguchi, S; Kuroda, M; Maki, Y; Matsubara, N; Murakami, J; Nagatsuka, H; Tanaka, N; Tsujigiwa, H; Yanagi, Y | 1 |
| Biswas, K; Chang, S; Haines, DC; Kaldis, P; Kanugula, S; Kuznetsov, SG; Loktionova, NA; Pegg, AE; Philip, S; Sharan, SK; Swaminathan, S | 1 |
| Jin, YH; Liu, HY; Shu, F; Wang, QJ; Wang, Z; Yang, Y; Zhang, WB | 1 |
| Bertrand, R; Bodo, S; Bouvet, D; Colas, C; Coulet, F; Duval, A; Guillerm, E; Muleris, M; Munier, A | 1 |
17 other study(ies) available for o(6)-benzylguanine and methylnitronitrosoguanidine
| Article | Year |
|---|---|
Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Amino Acid Sequence; Antibodies; Blotting, Western; Cell-Free System; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1991 |
A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.
Topics: Amino Acid Sequence; Base Sequence; Cell Survival; Escherichia coli; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Point Mutation; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity | 1993 |
Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Survival; Ethyl Methanesulfonate; Guanine; HL-60 Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Leukemia, T-Cell; Methylnitronitrosoguanidine; Methyltransferases; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured | 1996 |
O6-methylguanine induces intrachromosomal homologous recombination in human cells.
Topics: Cells, Cultured; Cinnamates; DNA Adducts; Gene Conversion; Guanine; Humans; Hygromycin B; Methylnitronitrosoguanidine; Recombination, Genetic; Thymidine Kinase | 1996 |
Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents.
Topics: Alkylating Agents; Animals; Cell Division; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Enzyme Inhibitors; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Thioguanine | 1997 |
Creation of human alkyltransferases resistant to O6-benzylguanine.
Topics: Binding Sites; Carcinogens; Drug Resistance; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transformation, Genetic | 1997 |
Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Temozolomide; Tumor Cells, Cultured | 1996 |
Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.
Topics: 3T3 Cells; Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Base Pair Mismatch; Chromosomes, Human, Pair 2; DNA Methylation; DNA Repair; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Transfer Techniques; Genotype; Guanine; HeLa Cells; Humans; Melanoma, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Species Specificity; Tumor Cells, Cultured | 1999 |
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.
Topics: Animals; Apoptosis; Cells, Cultured; Cisplatin; Dacarbazine; DNA Repair; DNA-Binding Proteins; Guanine; Intestinal Mucosa; Intestine, Small; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Mutagenesis; Mutagens; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Stem Cells; Temozolomide | 1999 |
Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Repair; DNA, Complementary; Drosophila melanogaster; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thymine; Transcription Factors | 1999 |
Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antineoplastic Agents; Binding Sites; Conserved Sequence; DNA Repair; Drug Resistance; Escherichia coli; Gene Library; Guanine; Humans; Methylnitronitrosoguanidine; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Sequence Alignment | 2000 |
Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antineoplastic Agents; Binding Sites; Carmustine; CHO Cells; Conserved Sequence; Cricetinae; DNA; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Humans; Lysine; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Sequence Alignment; Transfection | 2000 |
Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.
Topics: DNA Damage; DNA Repair; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Lac Operon; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Point Mutation; Substrate Specificity; Thymine | 2000 |
Role of O6-methylguanine-DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cisplatin; DNA Repair; Docetaxel; Drug Resistance, Neoplasm; Guanine; Humans; Methylnitronitrosoguanidine; Mouth Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Taxoids | 2005 |
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.
Topics: Alkylating Agents; Amino Acid Sequence; Animals; BRCA2 Protein; DNA Repair; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Mice; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase | 2008 |
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mechanistic Target of Rapamycin Complex 1; Methylnitronitrosoguanidine; Multiprotein Complexes; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2010 |
Methylation Tolerance-Based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome.
Topics: Biological Assay; Cell Line, Tumor; Colorectal Neoplasms, Hereditary Nonpolyposis; Computer Simulation; DNA Methylation; DNA Mismatch Repair; Feasibility Studies; Genetic Testing; Germ-Line Mutation; Guanine; Humans; Methylnitronitrosoguanidine; MutL Protein Homolog 1; MutS Homolog 2 Protein | 2019 |