o(6)-benzylguanine has been researched along with hydrazine in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baumann, RP; Penketh, PG; Sartorelli, AC; Seow, HA; Shyam, K | 1 |
| Baumann, RP; Liu, MC; Luo, MZ; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, R | 1 |
| Baumann, RP; Ishiguro, K; Patridge, EV; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, R | 1 |
3 other study(ies) available for o(6)-benzylguanine and hydrazine
| Article | Year |
|---|---|
The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Cell Line; Cells, Cultured; CHO Cells; Cricetinae; Drug Synergism; Guanine; HL-60 Cells; Humans; Hydrazines; Isocyanates; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Sulfonamides; Transfection | 2005 |
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Line, Tumor; DNA; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Hydrazines; Mice; NADPH-Ferrihemoprotein Reductase; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Solubility; Structure-Activity Relationship; Sulfonamides; Xanthine Oxidase | 2011 |
A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.
Topics: Antineoplastic Agents; Cell Hypoxia; Cell Line; Enzyme Inhibitors; Guanine; HL-60 Cells; Humans; Hydrazines; Hydrogen Peroxide; O(6)-Methylguanine-DNA Methyltransferase; Oxidation-Reduction; Oxygen; Purines; Sulfonamides; Superoxides | 2012 |