Compounds > o(6)-benzylguanine

o(6)-benzylguanine and guanine

o(6)-benzylguanine has been researched along with guanine in 316 studies

Research

Studies (316)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's124 (39.24)18.2507
2000's134 (42.41)29.6817
2010's55 (17.41)24.3611
2020's3 (0.95)2.80

Authors

AuthorsStudies
Bigner, DD; Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Pegg, AE; Rich, J; Schold, SC1
Berger, MS; Bobola, MS; Ewers, TG; Muramoto, M; Silber, JR1
Beattie, C; Guzman, RC; Hamdan, MA; Mascharack, P; Nandi, S; Yang, J1
Bronstein, SM; Hooth, MJ; Skopek, TR; Swenberg, JA1
Dolan, ME; Mitchell, RB; Moschel, RC; Mummert, C; Pegg, AE1
Dolan, ME; Mitchell, RB; Moschel, RC1
Dolan, ME; Dumenco, LL; Gerson, SL; Moschel, RC; Pegg, AE1
Dolan, ME; Moschel, RC; Mummert, C; Pegg, AE; Stine, L; Wiest, L1
Dolan, ME; Moschel, RC; Pegg, AE1
Dolan, ME; Mitchell, RB; Moschel, RC; Pegg, AE; Stine, L1
Chae, MY; Dolan, ME; Moschel, RC; Pegg, AE; Swenn, K1
Dolan, ME; Gonzalez, FJ; Korzekwa, KR; Moschel, RC; Roy, SK1
Balis, FM; Berg, SL; Cole, DE; Gerson, SL; Godwin, K; Liu, L1
Faustman, EM; Kidney, JK1
Crone, TM; Kanugula, S; Pegg, AE1
Gerson, SL; Willson, JK1
Magull-Seltenreich, A; Zeller, WJ2
Edara, S; Goodtzova, K; Kanugula, S; Pegg, AE3
Bigner, DD; Catino, JJ; Dolan, ME; Friedman, HS; Keir, S; Marcelli, S; Pegg, AE; Schold, SC1
Dolan, ME; Erickson, LC; Marathi, UK2
Elder, RH; Fairbairn, LJ; Margison, GP; Rafferty, JA; Watson, AJ1
Ikenaga, M; Izumi, I; Kohda, K; Kowada, M; Mineura, K; Watanabe, K1
Chae, MY; Dolan, ME; Friedman, HS; Moschel, RC; Mullen, JH; Pegg, AE1
Bindra, DS; Stella, VJ; Williams, TD1
Crone, TM; Edara, S; Goodtzova, K; Pegg, AE1
Dolan, ME; Flora, KP; Friedman, HS; Grever, MR; Moschel, RC; Pegg, AE; Vishnuvajjala, BR1
Crone, TM; Goodtzova, K; Pegg, AE1
Hughes, SH; Moschel, RC; Pauly, GT1
Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME1
Ikenaga, M; Izumi, I; Kohda, K; Kowada, M; Koyama, K; Mineura, K; Terashima, I; Watanabe, K1
Elder, RH; Margison, GP; Rafferty, JA1
Anver, MR; Lijinsky, W; Moschel, RC; Pegg, AE1
Boosalis, M; Byers, TL; Dolan, ME; Moschel, RC; Pegg, AE; Samson, L; Swenn, K1
Kohda, K; Koyama, K; Terashima, I1
Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Schold, C1
Deen, DF; Dolan, ME; Gonzalez, GG; Marton, LJ; Pegg, AE; Sarkar, A1
Chae, MY; Dolan, ME; McDougall, MG; Moschel, RC; Pegg, AE; Swenn, K1
Dolan, ME; Grindey, GB; Moschel, RC; Pegg, AE1
O'Toole, SM; Pegg, AE; Swenberg, JA1
Dolan, ME; Erickson, LC; Kroes, RA; Marathi, UK1
Crone, TM; Pegg, AE1
Gerson, SL; Gordon, NH; Norton, K; Willson, JK; Zborowska, E1
Bishop, RE; Dolan, ME; Dunn, LL; Moschel, RC; Pauly, GT1
Biser, ND; Dolan, ME; English, HF; Moschel, RC; Pegg, AE1
Chen, JM; Ikenaga, M; Moschel, RC; Zhang, YP1
Baer, JC; Freeman, AA; Margison, GP; Newlands, ES; Rafferty, JA; Watson, AJ1
Furusho, K; Gerson, SL; Kubota, M; Liu, L; Wakazono, Y1
Ali-Osman, F; Friedman, HS; Srivenugopal, KS; Yuan, XH1
May, BL; Newlands, ES; Porteus, JK; Wedge, SR1
Loktionova, NA; Pegg, AE2
Alas, LG; Belanich, M; Citron, ML; Dolan, ME; Gander, M; Kibitel, JT; Lejeune, FJ; Li, BF; Pastor, MA; Randall, T; Schold, SC; Wasserman, P; White, AB; Yarosh, DB1
Gerson, SL; Lee, K; Liu, L; Wasan, E1
Newlands, ES; Wedge, SR1
Bishop, RE; Moschel, RC; Pauly, GT1
Ali-Osman, F; Bigner, DD; Elion, GB; Friedman, HS; Keir, S; Marcelli, S; Moynihan, K1
Dolan, ME; Gupta, E; Roy, SK1
Donovan, C; Dumenco, LL; Gerson, SL; Kastan, M; Phillips, W1
Gerson, SL; Hoppel, CL; Ingalls, ST; Stefan, TL; Willson, JK1
Ali, RB; Ayi, TC; Li, BF; Lim, A; Oh, HK; Teo, AK; Yarosh, DB1
Kohda, K; Terashima, I1
Newlands, ES; Porteous, JK; Wedge, SR2
Bonmassar, E; D'Atri, S; Graziani, G; Lacal, PM; Orlando, L1
Allay, JA; Gerson, SL; Koç, ON; Lee, K; Liu, L; Phillips, WP; Zaidi, NH1
Bhattacharyya, NP; Maher, VM; McCormick, JJ; Tsujimura, T; Zhang, H1
Chinnasamy, N; Dexter, TM; Fairbairn, LJ; Hickson, I; Margison, GP; Rafferty, JA1
Allay, JA; Gerson, SL; Koç, ON; Lee, KM; Liu, L; Phillips, WP; Reese, JS1
Gerson, SL; Liu, L; Markowitz, S1
Archer, GE; Bigner, DD; Dolan, ME; Friedman, HS; Kurpad, SN; McLendon, RE; Moschel, RC; Pegg, AE1
Armstrong, MJ; Galloway, SM1
Ashby, J; Chinnasamy, N; Dexter, TM; Fairbairn, LJ; Hickson, I; Margison, GP; Rafferty, JA; Tinwell, H1
Edara, S; Goodtzova, K; Kanugula, S; Moschel, RC; Pauly, GT; Pegg, AE2
Edgren, MR; Egyházi, S; Hansson, J; Kröckel, D; Mannervik, B; Ringborg, U1
Christians, FC; Coates, MM; Dawson, BJ; Loeb, LA1
Fukuchi, M; Kohda, K; Kowada, M; Mineura, K; Terashima, I1
Chung, L; Moschel, RC; Pegg, AE1
Gerson, SL; Gordon, NH; Liu, L; Markowitz, SD; Phillips, WP; Willson, JK; Zaidi, NH; Zborowska, E1
Douglas, KT; Hickson, I; Margison, GP; Moody, PC; Rafferty, JA; Speers, P; Wibley, JE1
Davis, BM; Gerson, SL; Koç, ON; Lee, K; Reese, JS; Schupp, JE1
Kawate, H; Kohda, K; Sakumi, K; Sekiguchi, M; Terashima, I1
Aquilina, G; Bignami, M; Ceccotti, S; Hampson, R; Martinelli, S1
Coffman, BL; Green, MD; Iyer, L; King, CD; Ratain, MJ; Roy, SK; Tephly, TR; Whitington, PF1
Gerson, SL; Koç, ON; Lee, K; Liu, L; Schupp, J1
Gerson, SL; Hoppel, CL; Ingalls, ST; Minkler, PE; Spiro, TP; Stefan, TL; Willson, JK1
Benincasa, E; Bonmassar, E; Faraoni, I; Franco, D; Graziani, G; Lacal, PM; Tentori, L1
Kanugula, S; Pegg, AE; Xu-Welliver, M1
Dolan, ME; Fasanmade, AA; Paras, PR; Ratain, MJ; Roy, SK; Schilsky, RL1
Chae, MY; Dolan, ME; Garbiras, BJ; Helft, P; Moschel, RC; Paras, P; Pegg, AE; Roy, SK1
Chinnasamy, N; Fairbairn, LJ; Laher, J; Rafferty, JA; Willington, MA1
Faustman, EM; Seeley, MR1
Chinnasamy, N; Dexter, TM; Fairbairn, LJ; Hickson, I; Lashford, LS; Margison, GP; Rafferty, JA; Thatcher, N1
Brent, TP; Harris, LC; Marathi, UK; Venable, CC1
Dolan, ME; Pegg, AE1
Brent, TP; Edwards, CC; Harris, LC; Houghton, PJ; Marathi, UK; Sorrentino, BP; Srivastava, DK; Vanin, EF1
Berger, MS; Blank, A; Bobola, MS; Silber, JR; Tseng, SH1
Ashley, DM; Bigner, DD; Cokgor, I; Dolan, ME; Friedman, AH; Friedman, HS; Haglund, MM; Herndon, JE; Kerby, T; Kokkinakis, DM; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Rich, J; Schold, SC1
Balis, FM; Berg, SL; Godwin, K; McCully, CL; Murry, DJ1
Donnelly, DJ; Elder, RH; Kelly, J; Margison, GP; McCormick, JE; McElhinney, RS; McMurry, TB; Middleton, MR; Rafferty, JA; Watson, AJ; Willington, MA1
Kleibl, K; Margison, GP1
Davis, BM; Gerson, SL; Liu, L; Reese, JS1
Dolan, ME; Friedman, HS; Kokkinakis, DM; Lohrbach, KE; Olopade, OI; Wu, MH1
Aquilina, G; Bignami, M; Branch, P; Fiumicino, S; Humbert, O; Karran, P; Oda, S; Zijno, A1
Arends, MJ; Clarke, AR; Dekker, M; Howard, LA; Kelly, J; Margison, GP; te Riele, H; Toft, NJ; Winton, DJ; Wyllie, AH1
Gerson, SL; Liu, L; Pegg, AE; Schupp, J; Srinivasen, S1
Kooistra, R; Lohman, PH; Margison, GP; Pastink, A; Watson, AJ; Zonneveld, JB1
Bibby, MC; Margison, GP; McElhinney, RS; Rafferty, JA; Thompson, MJ1
Kanugula, S; Leitão, J; Pegg, AE; Xu-Welliver, M1
Davis, BM; Gerson, SL; Koç, ON; Liu, L; Majczenko, KJ; Reese, JS1
Gerson, SL; Haaga, J; Hoppel, CL; Ingalls, ST; Liu, L; Majka, S; Pluda, JM; Spiro, TP; Willson, JK1
Davis, BM; Gerson, SL; Koç, ON; Reese, JS1
Crone, TM; Kanugula, S; Loktionova, NA; Pegg, AE; Xu-Welliver, M2
Gerson, SL; Phillips, WP1
Erickson, LC; Kurpad, C; Maze, R; Pegg, AE; Williams, DA1
Kanugula, S; Leitão, J; Meehan, WJ; Pegg, AE; Xu-Welliver, M1
Chinnasamy, D; Chinnasamy, N; Dexter, T; Fairbairn, L; Lashford, L; Margison, G; Rafferty, J; Thatcher, N1
Erickson, LC; Kreklau, EL; Kurpad, C; Williams, DA1
Alvino, E; Bonmassar, E; D'Atri, S; Lacal, PM; Nunziata, C; Pagani, E; Pepponi, R1
Davis, BM; Gerson, SL; Liu, L; Pegg, AE; Roth, JC; Xu-Welliver, M1
Bissonnette, M; Brasitus, TA; Dolan, ME; Hart, J; Moschel, RC; Mustafi, R; Nguyen, L; Skarosi, S; Wali, RK; Zhang, Y1
Donnelly, DJ; Kelly, J; Margison, GP; McCormick, JE; McElhinney, RS; McMurry, TB; Middleton, MR; Thatcher, N1
Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Pegg, AE; Xu-Welliver, M1
Arends, MJ; Brookes, RA; Clarke, AR; Margison, GP; Sansom, OJ; Toft, NJ; Winton, DJ; Wood, M1
Pegg, AE1
Eberhardt, W; Heim, MM; Müller, MR; Seeber, S1
Davis, BM; Gerson, SL; Koç, ON1
Bigner, DD; Dolan, ME; Friedman, HS; Keir, ST; Lawless, A; Moschel, RC; Pegg, AE1
Abdul-Rahman, S; Baker, TG; Bibby, MC; Margison, GP; Rafferty, JA; Thompson, MJ1
Encell, LP; Loeb, LA1
Gao, H; Lu, H; Wan, Y; Wu, D1
Erickson, LC; Kurpad, C; Maze, R; Pegg, A; Williams, DA1
Boley, SE; Maher, VM; McCormick, JJ; McManus, TP1
Daniels, DS; Tainer, JA1
Friedman, HS1
Bertucci, D; Dolan, ME; Ewesuedo, RB; Mani, S; Ratain, MJ; Schilsky, RL; Vogelzang, NJ; Wilson, LR1
Dolan, ME; Ewesuedo, RB1
Balis, FM; Berg, SL; Dolan, ME; Long, L; McCully, CL; Moschel, RC; Roy, SK; Song-Yoo, HW1
Bailey, J; Chandra, S; Cooper, R; D'Souza, M; Pegg, AE; Ragg, S; Seshadri, R; Williams, DA; Xu-Welliver, M1
Ashley, DM; Bigner, DD; Cokgor, I; Colvin, OM; Dolan, ME; Ewesuedo, RB; Friedman, AH; Friedman, HS; Garcia-Turner, AM; Haglund, MM; Herndon, JE; Long, L; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Provenzale, JM; Quinn, JA; Rich, JN; Sampson, J; Stewart, ES; Tourt-Uhlig, S1
Cai, Y; Dolan, ME; Ludeman, SM; Pegg, AE; Wu, MH; Xu-Welliver, M1
Brem, H; Dolan, ME; Rhines, LD; Sampath, P; Tyler, BM; Weingart, J1
Brent, TP; Houghton, P; Sawai, N; Sorrentino, BP; Vanin, EF; Zhou, S1
Goodtzova, K; Kanugula, S; Loktionova, NA; Moschel, RC; Pauly, GT; Pegg, AE1
Bocangel, DB; Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Borowski, P; Bretner, M; Felczak, K; Kulikowski, T; Mueller, O; Niebuhr, A; Schmitz, H1
Dolan, ME; Long, L; Moschel, RC1
Christmann, M; Kaina, B; Lage, H; Pick, M; Schadendorf, D1
Christians, FC; Davis, BM; Encell, LP; Friebert, SE; Gerson, SL; Liu, L; Loeb, LA; Zielske, SP1
Cornetta, K; Erickson, LC; Kreklau, EL; Li, Z; Liu, N1
Blokland, I; Boudewijn, A; Down, JD; Margison, GP; McGown, AT; Ploemacher, RE; Watson, AJ; Westerhof, GR; Wood, M1
Moschel, RC; Pauly, GT1
Crankshaw, DL; Donaldson, EE; Kenney, PJ; Peterson, LA; Thomson, NM1
Gerson, SL; Haaga, J; Liu, L; Majka, S; Qin, X; Schupp, J; Spiro, TP; Willson, JK1
Abril, N; Luque-Romero, FL; Nohmi, T; Pueyo, C; Yamada, M1
Berger, NA; Berger, SJ; Dowlati, A; Gerson, SL; Haaga, J; Liu, L; Remick, SC; Spiro, TP; Willson, JK1
Gerson, SL; Koç, ON; Lee, K; Maitra, B1
Dolan, ME; Long, L1
Gao, H; Wan, Y; Wu, D1
Guengerich, FP; Woodside, AM2
Berman, E; Gallo, JM; Ma, J; Murphy, M; O'Dwyer, PJ; Reed, K1
Bigner, DD; Colvin, OM; Delaney, S; Dolan, ME; Friedman, AH; Friedman, HS; Gururangan, S; Haglund, MM; Herndon, JE; Kaplan, R; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Provenzale, JM; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Tourt-Uhlig, S1
Gerson, SL1
Davis, BM; Gerson, SL; Liu, L; Schwartz, S1
Bertucci, D; Dolan, ME; Karrison, T; Posner, M; Radosta, J; Ratain, MJ; Steinberg, G; Vujasin, L1
Biser-Rohrbaugh, A; Bunton, TE; Carson, BS; Gabikian, P; Guarnieri, M; Tyler, BM; Weingart, J; Wu, QZ1
Cai, Y; Chung, AB; Dolan, ME; Ludeman, SM; Wilson, LR1
Bigner, DD; Colvin, OM; Dolan, ME; Friedman, HS; Houghton, PJ; Keir, S; Moschel, RC; Pegg, AE1
Dalessio, PM; Fried, MG; Kanugula, S; Pegg, AE; Rasimas, JJ; Ropson, IJ1
Berger, MS; Erickson, LC; Hirose, Y; Kreklau, EL; Pieper, RO1
Allay, ER; Brent, TP; Hanawa, H; Hargrove, PW; Nienhuis, AW; Persons, DA; Sawai, N; Sorrentino, BP1
Gendreizig, S; Gronemeyer, T; Johnsson, K; Juillerat, A; Keppler, A; Pick, H; Vogel, H1
George, N; Johnsson, K; Johnsson, N; Kindermann, M1
Bowman, JE; Gerson, SL; Lingas, KT; Reese, JS1
Dolan, ME; Gandhi, MC; Ludeman, SM; Smith, SM; Springer, JB; Wilson, LR1
Delaney, SM; Dolan, ME; Egorin, MJ; Fishel, ML; Friesen, LD; Hansen, RJ; Moschel, RC; Zuhowski, EG1
Kanugula, S; Pegg, AE1
Germano, IM; Ito, H; Kanzawa, T; Kondo, S; Kondo, Y; Kyo, S1
Davis, BM; Gerson, SL; Lingas, K; Reese, JS1
Cupissol, D; Cuq, P; Depeille, P; Evrard, A; Montero, JL; Passagne, I; Vian, L; Winum, JY1
Ahmed, MM; Chendil, D; Kokkinakis, DM; Moschel, RC; Pegg, AE1
Donze, JR; Gerson, SL; Lingas, KT; Reese, JS; Zielske, SP1
Gendreizig, S; Johnsson, K; Kindermann, M1
Bedwell, J; Germano, IM; Kanzawa, T; Kondo, S; Kondo, Y1
Bailey, BJ; Erickson, LC; Hartwell, JR; Kreklau, EL; Liu, N; Pollok, KE; Williams, DA1
Davis, BM; Dropulic, B; Humeau, L1
Gendreizig, S; Johnsson, K; Keppler, A; Kindermann, M; Pick, H; Vogel, H1
Dunkel, IJ; Edgar, MA; Mark, EB; Occhiogrosso, G; Souweidane, MM1
Gerson, SL; Li, Y; Lingas, KT; Zielske, SP1
Cario-André, M; de Verneuil, H; Ged, C; Géronimi, F; Gerson, SL; Moreau-Gaudry, F; Richard, E; Robert, E1
Adams, D; Aleksic, A; Berg, S; Bernstein, M; Blaney, S; Neville, K; Thompson, P1
Choi, U; DeRavin, SS; Linton, GF; Loktionova, NA; Malech, HL; Pegg, AE; Whiting-Theobald, N; Yamashita, K1
Bacolod, MD; Bigner, DD; Bullock, NS; Colvin, OM; Dolan, ME; Fang, Q; Friedman, HS; Johnson, SP; Modrich, P; Moschel, RC; Pegg, AE1
Koch, M; Koomen, GJ; Wanner, MJ1
Loktionova, NA; Moschel, RC; Pegg, AE; Wei, G1
Delaney, SM; Dolan, ME; Egorin, MJ; Fishel, ML; Gamcsik, MP; Karrison, T; Maher, VM; Moschel, RC; Zuhowski, EG1
Donze, JR; Liu, L; Yan, L1
Blank, A; Bobola, MS; Ellenbogen, RG; Geyer, JR; Goff, RD; Silber, JR1
Cai, S; Cooper, RJ; Ferkowicz, MJ; Hartwell, JR; Kelley, MR; Pollok, KE; Xu, Y1
Asaumi, J; Fukui, K; Kawai, N; Kishi, K; Kokeguchi, S; Kuroda, M; Maki, Y; Matsubara, N; Murakami, J; Nagatsuka, H; Tanaka, N; Tsujigiwa, H; Yanagi, Y1
Bigner, DD; Birch, R; Brem, H; Dancey, JE; Delaney, SM; Desjardins, A; Dolan, ME; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Maxwell, J; McLendon, RE; Moschel, RC; Pegg, AE; Provenzale, JM; Quinn, JA; Reardon, DA; Rich, J; Sampson, JH; Tourt-Uhlig, S; Vredenburgh, J; Weingart, J1
Aikin, AA; Balis, FM; Fox, E; Libucha, M; Packer, RJ; Warren, KE; Widemann, BC1
Dolan, E; Gajewski, TF; Gerson, SL; Lin, S; Liu, L; Sosman, J; Vokes, EE1
Bleibel, WK; Dolan, ME; Fishel, ML; Li, X; Moschel, RC; Rabik, CA1
Kosenko, IG; Moshkovskaia, EIu; Vasil'eva, SV1
Baumann, RP; Penketh, PG; Sartorelli, AC; Seow, HA; Shyam, K1
Covas, DT; Davis, BM; Encell, LP; Fontes, AM; Gerson, SL; Lingas, K; Loeb, LA; Pegg, AE; Zago, MA1
Agamah, ES; Brockstein, BB; Delaney, SM; Dolan, ME; McLendon, R; Ryan, CW; Samuels, BL; Vokes, EE1
Friedman, H; Shankar, S; Vaidyanathan, G; Zalutsky, MR1
Chidley, C; Gronemeyer, T; Heinis, C; Johnsson, K; Juillerat, A1
Ding, J; Geng, MY; Meng, LH; Miao, ZH1
Dolan, ME; Njoku, MC; Rabik, CA1
Middleton, MR; Sabharwal, A1
Baum, C; Fujita, J; Itoh, K; Itoh, Y; Masuda, T; Okanoue, T; Umemura, A; Yamaguchi, K1
Aldape, K; Black, PM; Chakravarti, A; Erkkinen, MG; Gilbert, MR; Loeffler, JS; Mehta, M; Nestler, U; Stupp, R1
Arrivoli, C; Ellenberg, J; Keppler, A; Sironi, L1
Alvino, E; Bonmassar, E; Caporali, S; Caporaso, P; Castiglia, D; D'Atri, S; Fischer, F; Jiricny, J; Lacal, PM; Marra, G; Pepponi, R; Zambruno, G1
Boor, S; Hundsberger, T; Kaina, B; Koch, D1
Delaney, SM; Dolan, ME; Hansen, RJ; Nagasubramanian, R; Samson, LD1
Chen, CC; D'Andrea, A; Taniguchi, T1
Carson, KA; Delaney, SM; Dolan, ME; Fisher, JD; Grossman, SA; Judy, K; Olivi, A; Rosenblum, ML; Tatter, SB; Weingart, J1
Juillerat, A; Juillerat-Jeanneret, L1
Angel, KC; Egli, M; Eoff, RL; Guengerich, FP1
Bahlis, N; Batts, ED; Fu, P; Gerson, SL; Kane, D; Liu, L; Maisel, C; O'Brien, T; Remick, S1
Asaumi, J; Fukui, K; Kokeguchi, S; Kuroda, M; Lee, YJ; Matsubara, N; Murakami, J; Nagatsuka, H; Tanaka, N; Tsujigiwa, H1
Ball, CR; Fessler, S; Glimm, H; Pilz, IH; Schmidt, M; von Kalle, C; Williams, DA1
Beaufils, F; Maddox, E; Mottram, LF; Peterson, BR; Schwab, M1
Billups, CA; Danks, MK; McLendon, RE; Wagner, LM; Weiss, BD; Yoon, KJ1
Adema, AD; Bhakat, KK; Boven, E; Fontijn, D; Peters, GJ; Pinedo, HM1
Adams, DM; Berg, SL; Bernstein, M; Blaney, SM; Neville, K; Zhou, T1
Boyett, JM; Broniscer, A; Danks, MK; Friedman, HS; Gajjar, A; Goldman, S; Gururangan, S; Kun, LE; MacDonald, TJ; Packer, RJ; Poussaint, TY; Stewart, CF; Wallace, D1
Arnold, A; Banala, S; Johnsson, K1
Ogawa, M; Ueda, T; Yamauchi, T1
Benhattar, J; Bernasconi, CC; Bricod, C; Gros, S; Janzer, RC; Juillerat-Jeanneret, L; Trepey, S1
Dolan, ME; Egorin, MJ; Fishel, ML; Holleran, JL; Kasza, K; Kelley, MR; Rabik, CA1
Ishiguro, K; Penketh, PG; Sartorelli, AC; Shyam, K1
Fang, Q; Guida, WC; Loktionova, NA; Pauly, GT; Pegg, AE; Vankayala, SL1
Bartnik, CM; Dolan, ME; Kasza, K; Maryon, EB; Rabik, CA; Shafer, JT1
Biswas, K; Chang, S; Haines, DC; Kaldis, P; Kanugula, S; Kuznetsov, SG; Loktionova, NA; Pegg, AE; Philip, S; Sharan, SK; Swaminathan, S1
Bigner, DD; Carter, J; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Threatt, S; Vredenburgh, JJ1
Aebischer, A; Bannwarth, M; Correa, IR; Fellay, C; Johnsson, K; Pouvreau, S; Rois, E; Royer, L; Sztretye, M1
Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Vredenburgh, JJ; Walker, A2
Cadet, J; Fuchs, RP; Gasparutto, D; Mazon, G; Philippin, G1
Desjardins, A; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Sampson, JH; Vredenburgh, JJ1
Alexander, IE; Gunning, PW; Hardeman, EC; Hook, J; Joya, JE; Kahatapitiya, P; Kramer, B; Lee, AS; Liu, R; McCowage, G; Montarras, D; Schevzov, G1
Aikin, AA; Balis, FM; Cole, DE; Fox, E; Meany, HJ; Warren, KE1
Choi, U; Clevenger, JR; Donahue, RE; Dunbar, CE; Kang, E; Krouse, A; Larochelle, A; Loktionova, NA; Malech, HL; Metzger, M; Naumann, N; Persons, D; Shou, Y; Sorrentino, BP; Stewart, C1
Parang, K; Tiwari, R1
Coffey, M; Hollywood, D; Lawler, M; Marignol, L; Marples, B; Martin, L1
Baker, CH; Bhakat, KK; Bobustuc, GC; Colon, J; Isley, B; Kalkunte, SS; Konduri, SD; Srivenugopal, KS; Sutphin, RM; Ticku, J1
Cruz-Vallejo, VL; Morales-Ramírez, P; Vallarino-Kelly, T1
Adair, JE; Beard, BC; Ironside, C; Kiem, HP; McCune, JS; Trobridge, GD1
Palomo, J; Robinson, C; Vogelbaum, MA1
Johnsson, K; Kamiya, M1
Bachmann, J; Ehrhard, T; Herten, DP; Klingmüller, U; Lymperopoulos, K; Öz, S; Pfeifer, AC; Schulmeister, S; Siegberg, D; Sourjik, V; Stöhr, K1
Jin, YH; Liu, HY; Shu, F; Wang, QJ; Wang, Z; Yang, Y; Zhang, WB1
Ahmed, MM; Gupta, S; Sathishkumar, S1
Affleck, DJ; McDougald, D; Vaidyanathan, G; White, B; Zalutsky, MR1
Bailey, B; Baluyut, AR; Cai, S; Chan, RJ; Ernstberger, A; Goebel, WS; Jones, DR; Juliar, BE; Mayo, LD; Pollok, KE; Sinn, AL; Wang, H1
Baumann, RP; Liu, MC; Luo, MZ; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, R1
Balis, FM; Berg, SL; Boyett, JM; Geyer, JR; Goldman, S; Gururangan, S; Kun, LE; McLendon, RE; Minturn, JE; Packer, RJ; Pollack, IF; Poussaint, TY; Wallace, D; Warren, KE1
Barth, S; Hussain, AF; Kampmeier, F; Merk, HF; Tur, MK; von Felbert, V1
Cole, NB; Donaldson, JG1
Apisarnthanarax, N; Carlson, S; Chan, DV; Cooper, KD; Fu, P; Gerson, SL; Gilliam, AC; Liu, L; Remick, SC; Stevens, SR; Szabo, SK; Wood, GS1
Azoulay, M; Dingli, F; Florent, JC; Johannes, L; Lamaze, C; Loew, D; Shi, G1
Baidas, S; Baker, CH; Bobustuc, GC; Caparas, ML; Constantino, SM; Isley, B; Jeudy, S; Konduri, SD; Limaye, A; Maddipatla, S; Shah, N; Smith, JS; Srivenugopal, KS1
Baumann, RP; Ishiguro, K; Patridge, EV; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, R1
Cao, Q; Peterson, LA; Upadhyaya, P; Urban, AM1
Ishiguro, K; Kwon, Y; Lamb, KL; Liu, Y; Paquet, N; Rockwell, S; Sartorelli, AC; Sung, P; Sweasy, JB1
Baumann, RP; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, R1
Bailey, BJ; Baluyut, AR; Cai, S; Cai, W; Crean, C; Czader, MB; Ernstberger, A; Goebel, WS; Mayo, LD; Pollok, KE; Shokolenkoc, I; Suvannasankha, A; Wang, H; Wang, MZ; Wilson, GL1
Gahlon, HL; Schweizer, WB; Sturla, SJ1
Hatzidaki, E; Papandreou, CN; Vlachostergios, PJ1
Barth, S; Calderón, M; Haag, R; Hussain, AF; Kampmeier, F; Kratz, F; Krüger, HR; Licha, K; Weissbach, T1
Huang, F; Jiang, Y; Pei, Y; Qian, L; Tang, Y; Wang, K; Zhang, H; Zhang, X; Zheng, J1
Cho, SH; Guengerich, FP1
Beaufils, F; Bochet, CG; Cal, R; Constable, E; Hoffmann, V; Janett, E; Wymann, MP; Zimmermann, M1
Ackermann, M; Brennig, S; Lachmann, N; Modlich, U; Moritz, T; Phaltane, R1
Fan, T; Li, S; Sun, G; Zhao, L; Zhong, R1
Wetmore, SD; Wilson, KA1
Desai, A; Gerson, S1
Adair, JE; Baldock, AL; Beard, BC; Born, DE; Bridge, CA; Gonzalez-Cuyar, LF; Gori, JL; Guyman, LA; Hawkins-Daarud, A; Johnston, SK; Kiem, HP; Mrugala, MM; Rockhill, JK; Rockne, RC; Silbergeld, DL; Storer, BE; Swanson, KR1
Gholami, Z; Hanley, Q1
Chiarelli, PA; Ellenbogen, RG; Fang, C; Hatzinger, SJ; Kievit, FM; Silber, JR; Stephen, ZR; Veiseh, O; Wang, K; Zhang, M1
Boby, ML; Gahlon, HL; Sturla, SJ1
Barr, JT; Jones, JP; Oberlies, NH; Paine, MF1
Bobustuc, GC; Frick, J; Konduri, SD; Patel, A; Srivenugopal, KS; Thompson, M; Weese, J1
Barth, S; Bauerschlag, D; Bräutigam, K; Hussain, AF; Maass, N; Meinhold-Heerlein, I; von Felbert, V; Woitok, M1
Barth, S; Bialon, M; Fischer, R; Friesen, L; Grezella, C; Pham, AT; Püttmann, C; Sieben, T; Stein, C1
Marx, A; Nilforoushan, A; Sturla, SJ; Williams, DM; Wyss, LA1
Amoury, M; Barth, S; Bauerschlag, D; Berges, N; Bleilevens, A; Bräutigam, K; Di Fiore, S; Fischer, R; Hussain, AF; Maass, N; Meinhold-Heerlein, I; Mintert, I; Stickeler, E; von Felbert, V; Zeppernick, F1
Hashimoto, K; Nakamura, J; Sasanuma, H; Sharma, V; Swenberg, JA; Takata, M; Takeda, S; Tian, X1
Cassona, CP; Henriques, AO; Pereira, F; Serrano, M1
Jiang, Y; Li, X; Liu, C; Wang, F; Yao, S1
Chen, L; Song, X; Wang, C; Xiao, Y1
Carlson, S; Chan, DV; Cooper, KD; Dowlati, A; Fu, P; Gerson, SL; Groft, S; Honda, K; Lu, K; McCormick, TS; Rosenjack, J; Tacastacas, JD1
Arens, K; Berges, N; Di Fiore, S; Fischer, R; Kreusch, V1
Alexander, IE; Ching, YW; Dent, R; Kramer, B; McCowage, G; Middlemiss, S; Rush, A; Singh, R; Wischusen, J1
Li, JB; Li, Q; Merkle, T; Moschref, M; Selvasaravanan, KD; Stafforst, T; Vogel, P1
Hu, SX1
Abayaweera, G; Abou-Taleb, HA; AbouElhassan, KM; AbouTaleb, HA; Adair, LS; Adams, E; Addison, O; Addy, I; Akhtar, N; Alten, B; Anesini, J; Añez, R; Angaridis, PA; Aouba, A; Arakawa, K; Aumeeruddy-Elalfi, Z; Bao, LP; Basu, E; Bayraktar, E; Bekkelund, CS; Bell, J; Beraldo, H; Bermúdez, V; Betenbaugh, MJ; Bhattacharya, R; Bienvenu, B; Bolzoni, M; Bootz, F; Borja, JB; Bove, DG; Bowden, ME; Bradsher, C; Brockstedt, D; Brothers, RM; Buschauer, A; Calandriello, L; Caporossi, A; Carba, DB; Carratalà, J; Castella, B; Caviezel, D; Ceccato, R; Charalambidis, G; Charisiadis, A; Chattopadhyay, P; Chen, Q; Chen, W; Chen, Y; Chen, YT; Chen, ZJ; Chen, ZY; Cheng, MA; Cheng, ZB; Cherevko, S; Cheung, IY; Cheung, NV; Chiappini, A; Chiu, YL; Choi, IG; Chough, S; Chung, CY; Cobb, A; Colotto, A; Continentino, MA; Cook, AJMC; Costa, F; Coutsolelos, AG; Cuperus, N; Curtis, BM; Davenport, AJ; de Boysson, H; Dela, F; Deng, XP; Deshayes, S; Dhara, K; Dietrich, D; Dietrich, J; Dilhari, A; Ding, R; Ding, Y; Dirè, S; Dohlmann, TL; Dotsenko, A; Doubrovina, E; Du, K; Du, ZJ; Duvic, M; Eastman, A; Eliakim-Raz, N; Elz, S; Emile, JF; Emmerling, C; Engelhard, MH; Eriksson, JG; Etzold, BJM; Faini, AC; Falsini, B; Farmer, E; Fei, JJ; Ferreira, IP; Föttinger, K; Franconieri, F; Fryda, NJ; Fuentes, I; Galateau-Sallé, F; Ganguly, M; Gani, BA; Gao, X; Gao, XF; Gao, XJ; García-Mendiola, T; Garg, A; Gascon, J; Gayani, B; Gevensleben, H; Gilbert, M; Giudiceandrea, A; Giuliani, N; Gocmen, AY; Goldman, DA; Goltz, D; Gombert, AK; Gomila, A; Goodwin, P; Górnicki, K; Gostin, PF; Graterol, M; Gremillet, C; Grier, S; Grün, AL; Gusakov, A; Halldórsdóttir, HR; Han, L; Han, Z; Hävecker, M; Helge, JW; Heo, K; Hernández, JD; Hindsø, M; Holmen Olofsson, G; Hong, CE; Hong, J; Horenstein, AL; Hosenally, M; Hruz, P; Hsu, HL; Hsu, KC; Hu, SF; Hu, Y; Huang, K; Huang, S; Huang, WH; Humaira, A; Hung, CF; Hung, WS; Huo, XK; Huvinen, E; Idorn, M; Ignatyev, K; Im, WT; Ismaël, IS; Jakobsson, JG; Janaszek-Mańkowska, M; Jeong, GT; Ji, L; Ji, X; Jiang, Y; Jo, IH; Jo, SH; Johnson, AC; Johnson, LE; Kadirvelu, K; Kahnt, A; Kaleta, A; Kamiya, T; Kang, DH; Kang, XH; Kashiwagi, T; Katayama, E; Kawachi, N; Keller, M; Kellermann, L; Khan, T; Khan, ZA; Kharshoum, RM; Khim, JS; Kikuchi, M; Kim, BS; Kim, DS; Kim, DW; Kim, JH; Kim, JJ; Kim, JU; Kim, SK; Kim, WS; Kimura, J; Kiss, C; Knop-Gericke, A; Kobayashi, S; Koivusalo, SB; Kolar, E; Kottegoda, N; Kramer, K; Kristiansen, G; Kruger, AA; Kumar, S; Kumar, V; Kumarage, S; Kursungoz, C; Kushner, BH; Kuwahara, F; Kuzawa, C; Kwon, BO; Landsberg, J; Larsen, S; Lauer, P; Le Luduec, JB; Lee, DW; Lee, H; Lee, HY; Lee, JW; Lee, MJ; Lee, SW; Lefrançois, P; Leibovici, L; Leong, KK; Leong, M; Li, B; Li, D; Li, G; Li, J; Li, YZ; Liang, JH; Liang, X; Liens, A; Ligorio, G; Lin, JD; Lindholm, MG; Liou, MJ; List-Kratochvil, EJW; Litvinov, IV; Liu, F; Liu, S; Liu, Y; Liu, Z; Lohar, S; Lopes, MTP; Lorenzo, E; Lu, X; Lukashuk, L; Lukens, WL; Luo, HR; Luo, L; Luttik, MAH; Ma, Y; MacGowan, A; Mahomoodally, MF; Maissen, S; Malavasi, F; Malhotra, M; Mallik, S; Manna, D; Mans, R; Marangoni, D; Marimpietri, D; Marques, F; Marques, WL; Marsaa, K; Martin Silva, N; Martinez, A; Martínez, MS; Massaia, M; Mayrhofer, KJJ; McDade, T; McNeel, DG; Met, Ö; Micalizio, GC; Modak, S; Morandi, F; Moreau, L; Morla, S; Morrell, AP; Morris, S; Mubarak, Z; Muchlisin, ZA; Munoz, M; Nagao, Y; Nakama, T; Nakamura, H; Nakano, T; Nardi, MV; Nasirian, A; Nelson, MD; Netchiporouk, E; Ni, X; Niess, JH; Nijenhuis, JM; Nikolaou, V; O'Connor, BJ; O'Reilly, RJ; Odobel, F; Ohata, C; Ohyama, B; Olivar, LC; Ordoñez, MG; Ostrovnaya, I; Palmar, J; Panda, S; Pandiyarajan, S; Park, B; Park, H; Park, JH; Park, S; Pasquali, L; Patik, JC; Pearce, CI; Peele, ME; Peng, S; Perera, IC; Petty, JT; Pidko, EA; Pinheiro, CB; Pistoia, V; Pita, M; Planchat, A; Plass, F; Pockes, S; Pradhan, N; Premasudha, P; Pronk, JT; Provost, N; Pujol, M; Qi, P; Qiu, J; Qiu, Z; Quan, J; Quaranta, A; Ra, CH; Rameshan, R; Ranglack, DH; Rausch-Fan, X; Rieger, E; Rivas, JR; Roberts, SS; Rocha, WR; Rodrigues, GLS; Rojas, J; Roy, P; Rozhkova, A; Rufo, S; Rupprechter, G; Saeui, CT; Saha, A; Sakai, M; Salazar, J; Salem, HF; Salgarello, T; Samarakoon, SR; Sandau, C; Sandbeck, DJS; Santos, AF; Santos, VG; Sara, Y; Saslow, SA; Sasseville, D; Sato, S; Sauer, JD; Schlögl, R; Schweiger, MJ; Shashkov, I; Shaw, E; Shen, WQ; Shim, J; Shu, J; Singh, C; Sinha Babu, SP; Sinitsyn, A; Sinitsyna, O; Skadborg, SK; Song, Q; Song, W; Stach-Lempinen, B; Stoddart, M; Stoica, M; Street, SR; Sukwong, P; Sun, CP; Sun, J; Sunwoo, IY; Suresh, S; Szécsényi, Á; Takahashi, T; Takeda, S; Tang, D; Tas, ST; Tebé, C; Teixeira, LR; Teixidor, F; Terrier, B; Teschner, D; Tetzlaff, MT; Theisen, E; Thor Straten, P; Tiitinen, A; Timpel, M; Toccoli, T; Torikai, K; Torres, W; Toscani, D; Trad, S; Tsai, HJ; Tseng, CP; Tucker, WJ; Um, W; Vallejo-Torres, L; van den Broek, M; Van den Heuvel, L; van der Woude, LN; van Maris, AJA; Van Schepdael, A; Vank, C; Verucchi, R; Vigo, JM; Viñas, C; Vogt, TJ; Vuong, C; Wai, H; Wang, B; Wang, D; Wang, H; Wang, JJ; Wang, K; Wang, L; Wang, Q; Wang, YR; Watanabe, S; Watters, AK; Weerasekera, MM; Wei, L; Wheeler, DA; Wiegand, I; Wifling, D; Wijesinghe, GK; Winiczenko, R; Wolker, T; Wu, J; Wu, TC; Wu, YY; Xie, P; Xie, YP; Xu, A; Xu, E; Xu, L; Xu, Z; Yamaguchi, M; Yang, A; Yang, G; Yang, J; Yang, TM; Yang, W; Yang, Y; Yarema, KJ; Yesiltepe, M; Yi, KJ; Yigit, N; Yim, UH; Yin, B; Yu, S; Zengin, G; Zhang, B; Zhang, C; Zhang, GR; Zhang, H; Zhang, J; Zhang, L; Zhang, TY; Zhang, X; Zhang, Y; Zhang, YX; Zhao, H; Zhao, JC; Zhao, Z; Zheng, R; Zhou, W; Zorn Morales, N1
Chen, S; Lau, AJ; Saburulla, NF; Wong, SY; Xie, J; Yap, ZP; Zhang, LH1
He, H; Macias-Contreras, M; Zhu, L1
Bertrand, R; Bodo, S; Bouvet, D; Colas, C; Coulet, F; Duval, A; Guillerm, E; Muleris, M; Munier, A1
Fan, T; Li, Q; Liu, J; Wang, J; Wang, Y; Xiao, C; Yin, G; Zhang, Y; Zhao, X; Zheng, X1
Alshareef, M; Cachia, D; Das, A; Henderson, FC; Infinger, LK; Kanginakudru, I; Lindhorst, SM; Patel, SJ; Porto, GBF; Vandergrift, WA; Varma, AK1
Abbasi, A; Jones, JP; Joswig-Jones, CA1
Chen, WH; Hindle, A; Koneru, B; Lopez-Barcons, L; Makena, MR; Nguyen, TH; Reynolds, CP1

Reviews

12 review(s) available for o(6)-benzylguanine and guanine

ArticleYear
O6-alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance.
    Hematology/oncology clinics of North America, 1995, Volume: 9, Issue:2

    Topics: Alkylating Agents; Biological Transport; Carmustine; Clinical Trials as Topic; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Guanine; Humans; Inactivation, Metabolic; Methyltransferases; Neoplasm Proteins; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

1995
Role of DNA repair in resistance to drugs that alkylate O6 of guanine.
    Cancer treatment and research, 1996, Volume: 87

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Alkylating; DNA Repair; Drug Resistance; Genetic Therapy; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase

1996
O6-benzylguanine and its role in chemotherapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA Repair; Enzyme Inhibitors; Guanine; Humans; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous

1997
Increasing DNA repair capacity in bone marrow by gene transfer as a prospective tool in cancer therapy.
    Neoplasma, 1998, Volume: 45, Issue:4

    Topics: Alkylation; Amino Acid Sequence; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bone Marrow Cells; Cell Line; Cricetinae; Cricetulus; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Targeting; Gene Transfer Techniques; Guanine; Hematopoiesis; Hematopoietic Stem Cells; Humans; Mice; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid

1998
O6-benzylguanine-resistant mutant MGMT genes improve hematopoietic cell tolerance to alkylating agents.
    Progress in experimental tumor research, 1999, Volume: 36

    Topics: Alkylating Agents; Drug Resistance; Enzyme Inhibitors; Guanine; Hematopoietic Stem Cells; Humans; O(6)-Methylguanine-DNA Methyltransferase

1999
Repair of O(6)-alkylguanine by alkyltransferases.
    Mutation research, 2000, Volume: 462, Issue:2-3

    Topics: Alkyl and Aryl Transferases; Animals; DNA Adducts; DNA Repair; Guanine; Humans

2000
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase.
    Mutation research, 2000, Aug-30, Volume: 460, Issue:3-4

    Topics: Alkylation; Amino Acid Sequence; Amino Acid Substitution; Archaeal Proteins; Arginine; Bacterial Proteins; Binding Sites; Cysteine; DNA Damage; DNA Repair; Evolution, Molecular; Guanine; Helix-Turn-Helix Motifs; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Protein Binding; Protein Conformation; Sequence Alignment; Sequence Homology, Amino Acid

2000
Clinical relevance of MGMT in the treatment of cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, May-01, Volume: 20, Issue:9

    Topics: Antineoplastic Agents; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; Genetic Therapy; Guanine; Humans; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship

2002
Emerging cancer therapeutic opportunities target DNA-repair systems.
    Trends in pharmacological sciences, 2006, Volume: 27, Issue:6

    Topics: Animals; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Neoplasm; Drug Resistance, Neoplasm; Guanine; Humans; Morpholines; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Pyrones; Quinazolines; Signal Transduction; Tumor Suppressor Proteins

2006
Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
    Cancer treatment reviews, 2006, Volume: 32, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; DNA Repair Enzymes; Drug Resistance; Enzyme Inhibitors; Guanine; Hematopoietic Stem Cells; Humans; O(6)-Methylguanine-DNA Methyltransferase; Platinum Compounds

2006
Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy.
    Current opinion in pharmacology, 2006, Volume: 6, Issue:4

    Topics: Animals; Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Dacarbazine; DNA Adducts; DNA Methylation; DNA Topoisomerases, Type I; Drug Administration Schedule; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Guanine; Humans; Irinotecan; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Organoplatinum Compounds; Prognosis; Promoter Regions, Genetic; Temozolomide; Topoisomerase I Inhibitors

2006
S-alkylthiolation of O6-methylguanine-DNA-methyltransferase (MGMT) to sensitize cancer cells to anticancer therapy.
    Expert opinion on therapeutic targets, 2007, Volume: 11, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Mutation; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Protein Conformation

2007

Trials

28 trial(s) available for o(6)-benzylguanine and guanine

ArticleYear
Simultaneous determination of O6-benzylguanine and 8-oxo-O6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Dec-19, Volume: 704, Issue:1-2

    Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Guanine; Humans; Hydrogen-Ion Concentration; Quality Control; Sensitivity and Specificity

1997
O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:5

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Guanine; Half-Life; Humans; Infusions, Intravenous; Leukocytes, Mononuclear; Neoplasms

1998
Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:11

    Topics: Adult; Aged; Brain Neoplasms; Enzyme Inhibitors; Glioblastoma; Guanine; Humans; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Preoperative Care

1998
O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.
    Cancer research, 1999, May-15, Volume: 59, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy; Biotransformation; Breast Neoplasms; Carmustine; Digestive System Neoplasms; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Proteins; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Safety; Tomography, X-Ray Computed

1999
Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Dose-Response Relationship, Drug; Female; Guanine; Humans; Male; Middle Aged; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

2000
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Oct-15, Volume: 18, Issue:20

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Central Nervous System Neoplasms; Drug Administration Schedule; Glioblastoma; Guanine; Humans; Middle Aged; Neoplasm Recurrence, Local

2000
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, May-01, Volume: 20, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Glioma; Guanine; Humans; Male; Middle Aged; Nitrosourea Compounds; Treatment Outcome

2002
Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:8

    Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; CHO Cells; Cricetinae; DNA Methylation; DNA Repair; Dose-Response Relationship, Drug; Female; Guanine; Humans; Male; Middle Aged; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

2002
Pharmacokinetics of O(6)-benzylguanine in pediatric patients with central nervous system tumors: a pediatric oncology group study.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-01, Volume: 10, Issue:15

    Topics: Adolescent; Adult; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Central Nervous System Neoplasms; Chromatography, High Pressure Liquid; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Treatment Outcome

2004
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Oct-01, Volume: 23, Issue:28

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Glioma; Guanine; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Temozolomide

2005
Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Oct-20, Volume: 23, Issue:30

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Guanine; Humans; Injections, Intravenous; Male; Maximum Tolerated Dose; Neoplasms; Prognosis; Temozolomide

2005
Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Nov-01, Volume: 11, Issue:21

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carbon Monoxide; Carmustine; Cohort Studies; Disease Progression; Female; Guanine; Humans; Leukocytes, Mononuclear; Male; Melanoma; Middle Aged; Neoplasm Metastasis; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Treatment Outcome

2005
A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
    Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:5

    Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Enzyme Inhibitors; Female; Gastrointestinal Stromal Tumors; Guanine; Humans; Immunohistochemistry; Infant; Injections, Intravenous; Leiomyosarcoma; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Sarcoma; Survival Analysis; Tachycardia, Supraventricular; Thrombocytopenia; Treatment Outcome

2006
Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Feb-01, Volume: 25, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Delivery Systems; Female; Glioma; Guanine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase

2007
O6-benzylguanine and BCNU in multiple myeloma: a phase II trial.
    Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA; Drug Administration Schedule; Female; Follow-Up Studies; Guanine; Humans; Male; Middle Aged; Multiple Myeloma; Patient Selection; Reference Values

2007
Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:3

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; DNA Repair; DNA, Neoplasm; Enzyme Inhibitors; Female; Guanine; Humans; Male; Maximum Tolerated Dose; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Salvage Therapy

2008
Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Nov-15, Volume: 13, Issue:22 Pt 1

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Enzyme Inhibitors; Female; Guanine; Humans; Infant; Male; Temozolomide; Treatment Outcome

2007
Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Feb-01, Volume: 15, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Decanoic Acids; Female; Glioblastoma; Guanine; Humans; Male; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Polyesters; Recurrence; Survival Analysis

2009
Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Mar-10, Volume: 27, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Guanine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide

2009
Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.
    Neuro-oncology, 2009, Volume: 11, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Glioma; Guanine; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome

2009
Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.
    Cancer, 2009, Jul-01, Volume: 115, Issue:13

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Dacarbazine; Disease-Free Survival; Female; Glioma; Guanine; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Temozolomide

2009
Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors.
    Cancer chemotherapy and pharmacology, 2009, Volume: 65, Issue:1

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dacarbazine; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanine; Hematologic Diseases; Humans; Male; Neoplasms; Sex Factors; Tandem Mass Spectrometry; Temozolomide; Young Adult

2009
A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study.
    Journal of neuro-oncology, 2012, Volume: 106, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Brain Stem Neoplasms; Child; Child, Preschool; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Therapy, Combination; Female; Glioma; Guanine; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Male; Proportional Hazards Models; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins; Young Adult

2012
Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type.
    Archives of dermatology, 2012, Volume: 148, Issue:5

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Biopsy; Carmustine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Guanine; Humans; Infusions, Intravenous; Male; Middle Aged; Mycosis Fungoides; O(6)-Methylguanine-DNA Methyltransferase; Skin Neoplasms; Treatment Outcome

2012
Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.
    The Journal of clinical investigation, 2014, Volume: 124, Issue:9

    Topics: Adult; Bone Marrow; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Genetic Therapy; Glioblastoma; Guanine; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Models, Biological; Prospective Studies; Temozolomide; Tumor Suppressor Proteins

2014
Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial.
    JAMA dermatology, 2017, 05-01, Volume: 153, Issue:5

    Topics: Administration, Cutaneous; Administration, Intravenous; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Female; Guanine; Hospitals, University; Humans; Lymphoma, T-Cell, Cutaneous; Male; Maximum Tolerated Dose; Middle Aged; Mycosis Fungoides; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Skin Neoplasms; Treatment Outcome

2017
Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain Tumors.
    Human gene therapy, 2018, Volume: 29, Issue:8

    Topics: Brain Neoplasms; Child; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Genetic Therapy; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Male; Temozolomide; Tumor Suppressor Proteins

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosphate; Adipose Tissue; Administration, Intravaginal; Adolescent; Adsorption; Adult; Adverse Childhood Experiences; Age Distribution; Age Factors; Aged; Aged, 80 and over; Air Pollution, Indoor; Aldehyde Oxidase; Alginates; Alloys; alpha-Globins; Aluminum Hydroxide; Alveolar Bone Loss; Anaerobiosis; Anesthesia, General; Anesthetics; Animals; Anovulation; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Bacillus cereus; Bacterial Typing Techniques; Bacteroidetes; Base Composition; Biocompatible Materials; Biofilms; Biological Availability; Biological Transport; Biosensing Techniques; Bipolar Disorder; Blood Glucose; Body Mass Index; Bone Regeneration; Boranes; Brachial Artery; Butyric Acid; Candida albicans; Carbon; Carcinoembryonic Antigen; Cell Differentiation; Cell Line, Tumor; Cell Respiration; Cell Survival; Cells, Cultured; Cerebrovascular Circulation; Charcoal; Child; Child Health; China; Chloride Channels; Chlorides; CHO Cells; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromium; Chronic Disease; Chronic Periodontitis; Circular Dichroism; Cities; Cohort Studies; Comamonadaceae; Comorbidity; Coronary Artery Disease; Corrosion; Cricetinae; Cricetulus; Cross Infection; Cross-Sectional Studies; Crowding; Culture Media; Cytokines; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diarylheptanoids; Diclofenac; Disability Evaluation; Diterpene Alkaloids; DNA; DNA Mutational Analysis; DNA, Bacterial; Drug Liberation; Drug Resistance, Multiple, Bacterial; Electrochemical Techniques; Electrodes; Electrolytes; Endothelium, Vascular; Enterococcus faecalis; Epithelial Cell Adhesion Molecule; Epithelial Cells; Erbium; Erythropoietin; Ethanol; Ethylenediamines; Fast Foods; Fatty Acids; Female; Fermentation; Ferric Compounds; Fibroblasts; Flavobacteriaceae; Fluorides; Fluorodeoxyglucose F18; Food Microbiology; Formaldehyde; Furaldehyde; Gamma Cameras; Gene Expression; Geologic Sediments; Glucose Tolerance Test; Glycated Hemoglobin; Glycolipids; Glycosylation; Gracilaria; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Guanine; Health Surveys; HeLa Cells; Hemoglobins, Abnormal; Hexosamines; High Fructose Corn Syrup; High-Intensity Interval Training; Hip Fractures; Hippocampus; HLA-B27 Antigen; Hospitalization; Housing; Humans; Hydrogen-Ion Concentration; Hydrolysis; Hydroxides; Hypercapnia; Hypertension; Hypocreales; Hypromellose Derivatives; Image Processing, Computer-Assisted; Incidence; Indole Alkaloids; Indonesia; Inflammation Mediators; Infrared Rays; Insulin Resistance; Intercalating Agents; Ion Transport; Ionophores; Japan; Kinetics; Kluyveromyces; Letrozole; Linear Models; Lipopolysaccharides; Liposomes; Liver; Lung Diseases; Magnesium Hydroxide; Magnetic Resonance Spectroscopy; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice, Inbred BALB C; Microbial Sensitivity Tests; Microbial Viability; Microscopy, Electron, Transmission; Middle Aged; Mitochondria; Mitochondria, Muscle; Molecular Docking Simulation; Molecular Structure; Muscle, Skeletal; Mutant Proteins; Mutation; Mutation, Missense; Nanocomposites; Nanoparticles; Neoplasm Recurrence, Local; Neoplastic Cells, Circulating; Nucleic Acid Hybridization; Obesity; Occupational Exposure; Oceans and Seas; Odds Ratio; Organometallic Compounds; Osteogenesis; Ovulation Induction; Oxidation-Reduction; Particle Size; Periodontal Ligament; Permeability; Phaseolus; Phenotype; Philippines; Phosphatidylethanolamines; Phospholipids; Photochemical Processes; Phylogeny; Pichia; Pigmentation; Plant Extracts; Polycystic Ovary Syndrome; Polysaccharides; Postprandial Period; Pregnancy; Pregnancy Rate; Prevalence; Product Surveillance, Postmarketing; Progesterone; Progestins; Protein Engineering; Pseudomonas aeruginosa; Psoriasis; Public Facilities; Rats; Rats, Wistar; Receptors, Thyrotropin; Recombinant Proteins; Reproducibility of Results; Republic of Korea; Retrospective Studies; Rhodobacteraceae; Risk; Risk Assessment; Risk Factors; RNA, Ribosomal, 16S; ROC Curve; Saccharomyces cerevisiae; Salinity; Saliva; Seawater; Seaweed; Sensitivity and Specificity; Sequence Analysis, DNA; Sex Factors; Silver Compounds; Smokers; Social Class; Socioeconomic Factors; Soil Microbiology; Solubility; Soy Foods; Spectrometry, Mass, Electrospray Ionization; Spondylitis, Ankylosing; Staphylococcus aureus; Static Electricity; Steroids; Strontium; Sucrose; Surface Properties; Survival Rate; Sweden; Swine; Synapses; Synchrotrons; Tandem Mass Spectrometry; Tannins; Tea; Temperature; Terpenes; Thalidomide; Thermodynamics; Thiadiazoles; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroidectomy; Time Factors; Tissue Distribution; Titanium; Toilet Facilities; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Ubiquinone; Urinary Tract Infections; Vaginal Creams, Foams, and Jellies; Venezuela; Vitamin K 2; Waist Circumference; Waste Disposal, Fluid; Wastewater; Water Microbiology; Water Pollutants, Chemical; Whole Body Imaging; X-Ray Diffraction; Young Adult; Ytterbium; Yttrium; Yttrium Radioisotopes; Zinc Compounds

2018

Other Studies

276 other study(ies) available for o(6)-benzylguanine and guanine

ArticleYear
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
    Journal of the National Cancer Institute, 1992, Dec-16, Volume: 84, Issue:24

    Topics: Animals; Carmustine; Drug Resistance; Female; Glioblastoma; Guanine; Humans; Male; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous

1992
O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines.
    Oncology research, 1992, Volume: 4, Issue:6

    Topics: Carmustine; Cell Survival; Cerebellar Neoplasms; Drug Resistance; Guanine; Humans; Medulloblastoma; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1992
Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells.
    Carcinogenesis, 1992, Volume: 13, Issue:10

    Topics: Animals; Base Sequence; Breast; Cell Transformation, Neoplastic; Cells, Cultured; Collagen; Culture Media; Epithelial Cells; Epithelium; Female; Guanine; Humans; Menopause; Methyltransferases; Mice; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Rats

1992
Modulation of ethylnitrosourea-induced toxicity and mutagenicity in human cells by O6-benzylguanine.
    Cancer research, 1992, Jul-15, Volume: 52, Issue:14

    Topics: Alkylation; Cell Line, Transformed; Cell Survival; DNA Repair; Ethylnitrosourea; Guanine; Humans; Lymphocytes; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype

1992
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
    Cancer research, 1991, Jul-01, Volume: 51, Issue:13

    Topics: Alkylating Agents; Antineoplastic Agents; Carmustine; Cell Survival; Cisplatin; Cyclophosphamide; DNA; DNA Damage; Drug Synergism; Guanine; Humans; In Vitro Techniques; Lomustine; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured

1991
Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
    Cancer research, 1992, Mar-01, Volume: 52, Issue:5

    Topics: Animals; Carmustine; Colonic Neoplasms; DNA; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Female; Guanine; Humans; Lomustine; Mice; Mice, Nude; Transplantation, Heterologous; Tumor Cells, Cultured

1992
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.
    Carcinogenesis, 1991, Volume: 12, Issue:12

    Topics: Animals; Bacterial Proteins; CHO Cells; Cricetinae; DNA; Enzyme Activation; Escherichia coli Proteins; Guanine; Humans; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors; Transfection

1991
Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.
    Carcinogenesis, 1991, Volume: 12, Issue:9

    Topics: Amino Acid Sequence; Antibodies; Blotting, Western; Cell-Free System; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1991
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:14

    Topics: Antineoplastic Agents; Cell Line; Cell Survival; Drug Synergism; Guanine; Humans; Kidney; Kinetics; Liver; Lomustine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Tumor Cells, Cultured

1990
Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
    Cancer communications, 1990, Volume: 2, Issue:11

    Topics: Animals; Brain Neoplasms; Cricetinae; Dose-Response Relationship, Drug; Female; Glioma; Guanine; Humans; Kidney; Liver; Male; Methyltransferases; Mice; Mice, Inbred Strains; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Semustine; Tissue Distribution; Tissue Extracts; Transplantation, Heterologous; Tumor Cells, Cultured

1990
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
    Biochemical pharmacology, 1995, Oct-12, Volume: 50, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Cell Death; Drug Resistance; Drug Therapy, Combination; Enzyme Inhibitors; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1995
Human liver oxidative metabolism of O6-benzylguanine.
    Biochemical pharmacology, 1995, Oct-26, Volume: 50, Issue:9

    Topics: Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Cytosol; Guanine; Humans; Isoenzymes; Kinetics; Liver Neoplasms; Microsomes, Liver; Oxidation-Reduction; Tumor Cells, Cultured

1995
Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and time course of peripheral blood mononuclear cell O6-methylguanine-DNA methyltransferase inhibition in the nonhuman primate.
    Cancer research, 1995, Oct-15, Volume: 55, Issue:20

    Topics: Animals; DNA Repair; Enzyme Inhibitors; Guanine; Leukocytes, Mononuclear; Macaca mulatta; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Time Factors

1995
Modulation of nitrosourea toxicity in rodent embryonic cells by O6-benzylguanine, a depletor of O6-methylguanine-DNA methyltransferase.
    Toxicology and applied pharmacology, 1995, Volume: 133, Issue:1

    Topics: Animals; Cell Differentiation; Cells, Cultured; DNA Adducts; Ethylnitrosourea; Female; Guanine; Mesencephalon; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Pregnancy; Rats; Rats, Sprague-Dawley

1995
Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine.
    Carcinogenesis, 1995, Volume: 16, Issue:8

    Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Binding Sites; Escherichia coli Proteins; Guanine; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Transcription Factors

1995
Sensitization of human colon tumour cell lines to carmustine by depletion of O6-alkylguanine-DNA alkyltransferase.
    Journal of cancer research and clinical oncology, 1995, Volume: 121, Issue:4

    Topics: Carmustine; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Time Factors; Tumor Cells, Cultured

1995
Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine.
    Biochemistry, 1995, May-30, Volume: 34, Issue:21

    Topics: Alanine; Animals; Arginine; Base Sequence; Cattle; DNA; DNA Repair; DNA-Binding Proteins; Guanine; Humans; Methylation; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase

1995
Activity of temozolomide in the treatment of central nervous system tumor xenografts.
    Cancer research, 1995, Jul-01, Volume: 55, Issue:13

    Topics: Animals; Carmustine; Central Nervous System Neoplasms; Dacarbazine; Female; Guanine; Humans; Male; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Temozolomide; Transplantation, Heterologous

1995
Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
    Biochemical pharmacology, 1994, Nov-29, Volume: 48, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Glioblastoma; Guanine; Humans; Methyltransferases; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Inhibition of O6-alkylguanine-DNA alkyltransferase in animal and human ovarian tumor cell lines by O6-benzylguanine and sensitization to BCNU.
    Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Cystadenocarcinoma, Serous; Drug Resistance; Female; Guanine; Humans; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Ovarian Neoplasms; Rats; Tumor Cells, Cultured

1995
O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide.
    Experimental hematology, 1995, Volume: 23, Issue:2

    Topics: Alkylating Agents; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Dacarbazine; Granulocytes; Guanine; Humans; Macrophages; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

1995
Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours.
    Acta neurochirurgica, 1994, Volume: 128, Issue:1-4

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Basal Ganglia; Brain Neoplasms; Cell Count; Cell Division; Culture Techniques; DNA Repair; DNA, Neoplasm; Drug Synergism; Glioma; Guanine; Male; Nimustine; Rats; Rats, Wistar

1994
Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
    Cancer research, 1994, Oct-01, Volume: 54, Issue:19

    Topics: Animals; Guanine; Liver; Male; Methyltransferases; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley; Tissue Distribution

1994
Degradation of O6-benzylguanine in aqueous polyethylene glycol 400 (PEG 400) solutions: concerns with formaldehyde in PEG 400.
    Pharmaceutical research, 1994, Volume: 11, Issue:7

    Topics: Chromatography, High Pressure Liquid; Colorimetry; Drug Stability; Formaldehyde; Guanine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Polyethylene Glycols; Solubility; Water

1994
Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.
    Cancer research, 1994, Dec-01, Volume: 54, Issue:23

    Topics: Amino Acid Sequence; Base Sequence; Binding Sites; DNA; Drug Resistance; Guanine; Humans; Methyltransferases; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship

1994
Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
    Cancer chemotherapy and pharmacology, 1994, Volume: 35, Issue:2

    Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Carmustine; Child; Chromatography, High Pressure Liquid; Female; Glioblastoma; Glycerol; Guanine; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Polyethylene Glycols; Solubility; Tissue Distribution

1994
Activation of human O6-alkylguanine-DNA alkyltransferase by DNA.
    Biochemistry, 1994, Jul-19, Volume: 33, Issue:28

    Topics: Animals; Base Sequence; Cattle; DNA; Enzyme Activation; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Sodium Chloride; Structure-Activity Relationship

1994
Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Cancer research, 1994, Aug-15, Volume: 54, Issue:16

    Topics: Antineoplastic Agents; Carmustine; Deoxyguanosine; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Response of repair-competent and repair-deficient Escherichia coli to three O6-substituted guanines and involvement of methyl-directed mismatch repair in the processing of O6-methylguanine residues.
    Biochemistry, 1994, Aug-09, Volume: 33, Issue:31

    Topics: Base Sequence; Codon; DNA Repair; DNA Replication; Escherichia coli; Genes, Bacterial; Guanine; Methyltransferases; Models, Genetic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Plasmids

1994
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
    Biochemical pharmacology, 1994, Aug-03, Volume: 48, Issue:3

    Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathione; Glutathione Transferase; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase

1994
Enhancing effect of O6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells.
    International journal of cancer, 1994, Sep-01, Volume: 58, Issue:5

    Topics: Animals; Brain Neoplasms; Cell Survival; Drug Synergism; Guanine; HeLa Cells; Humans; Nimustine; Rats; Structure-Activity Relationship; Tumor Cells, Cultured

1994
Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine.
    The Biochemical journal, 1994, Feb-15, Volume: 298 ( Pt 1)

    Topics: Animals; Base Sequence; Cells, Cultured; Cricetinae; Cricetulus; Escherichia coli; Guanine; Humans; Methyltransferases; Mice; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Rats

1994
Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea.
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:3

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Ethylnitrosourea; Female; Guanine; Liver; Methylnitrosourea; Methyltransferases; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344

1994
Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
    Biochemistry, 1993, Nov-16, Volume: 32, Issue:45

    Topics: Animals; Base Sequence; Binding Sites; Cysteine; DNA Primers; Escherichia coli; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Species Specificity

1993
Chemical characteristics of complexes of O6,9-dimethylguanine with cis-platin and debenzylation rates of O6-benzylguanines.
    Nucleic acids symposium series, 1993, Issue:29

    Topics: Alkylation; Chromatography, High Pressure Liquid; Guanine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Organoplatinum Compounds; Spectrophotometry, Ultraviolet; Substrate Specificity

1993
Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Synergism; Guanine; Humans; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Time Factors

1993
The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:6

    Topics: Biogenic Polyamines; Brain Neoplasms; Carmustine; Cell Hypoxia; Combined Modality Therapy; Drug Resistance; Guanine; Humans; Ornithine Decarboxylase; Tumor Cells, Cultured

1993
Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase.
    Journal of medicinal chemistry, 1994, Feb-04, Volume: 37, Issue:3

    Topics: Colonic Neoplasms; Guanine; Humans; Methyltransferases; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Tumor Cells, Cultured

1994
Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
    Biochemical pharmacology, 1993, Jul-20, Volume: 46, Issue:2

    Topics: Animals; Carmustine; Cell Division; Colonic Neoplasms; Drug Synergism; Female; Guanine; Humans; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase

1993
Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine.
    Cancer research, 1993, Sep-01, Volume: 53, Issue:17

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; DNA; DNA Repair; Guanine; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344; Thymidine

1993
Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
    Cancer research, 1993, Sep-15, Volume: 53, Issue:18

    Topics: Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Streptozocin; Tumor Cells, Cultured

1993
A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.
    Cancer research, 1993, Oct-15, Volume: 53, Issue:20

    Topics: Amino Acid Sequence; Base Sequence; Cell Survival; Escherichia coli; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Point Mutation; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity

1993
Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone.
    Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carmustine; Colonic Neoplasms; Drug Resistance; Drug Synergism; Guanine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transferases; Tumor Cells, Cultured

1993
The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
    Carcinogenesis, 1993, Volume: 14, Issue:4

    Topics: Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Codon; DNA Damage; DNA Repair; Genes, ras; Guanine; Methyltransferases; Molecular Sequence Data; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Transfection

1993
Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:3

    Topics: Animals; Carmustine; Drug Interactions; Guanine; Kidney; Liver; Male; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Prostatic Neoplasms; Rats; Tumor Cells, Cultured

1993
Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro.
    Carcinogenesis, 1993, Volume: 14, Issue:5

    Topics: Antineoplastic Agents; Carmustine; Drug Resistance; Drug Synergism; Guanine; HeLa Cells; Humans; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Tumor Cells, Cultured

1993
Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.
    British journal of cancer, 1993, Volume: 67, Issue:6

    Topics: Antineoplastic Agents; Dacarbazine; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Lomustine; Methyltransferases; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured

1993
Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents.
    Mutation research, 1996, Jan-02, Volume: 362, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Survival; Ethyl Methanesulfonate; Guanine; HL-60 Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Leukemia, T-Cell; Methylnitronitrosoguanidine; Methyltransferases; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured

1996
Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Biochemistry, 1996, Jan-30, Volume: 35, Issue:4

    Topics: Adenosine Triphosphate; Animals; Blotting, Western; Carmustine; Chromatography, Affinity; Energy Metabolism; Guanine; Humans; Kinetics; Magnesium; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Rats; Tumor Cells, Cultured; Ubiquitins

1996
Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.
    British journal of cancer, 1996, Volume: 73, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Cell Line; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured

1996
Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
    Cancer research, 1996, Apr-01, Volume: 56, Issue:7

    Topics: Animals; Antineoplastic Agents; Base Sequence; Carmustine; Cell Survival; CHO Cells; Cricetinae; Drug Resistance; Guanine; Humans; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Transfection

1996
Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase.
    Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:6

    Topics: Animals; Cell Compartmentation; Cell Nucleus; Cytoplasm; Dacarbazine; DNA Repair; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Guanine; Humans; Image Processing, Computer-Assisted; Lung Neoplasms; Melanoma; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous

1996
Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.
    Cancer research, 1996, Apr-15, Volume: 56, Issue:8

    Topics: Animals; Antineoplastic Agents; Base Sequence; Carmustine; CHO Cells; Cricetinae; DNA Primers; Genetic Vectors; Guanine; Humans; Liver; Methyltransferases; Mice; Mice, Nude; Mice, Transgenic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombinant Fusion Proteins; Transfection

1996
O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.
    British journal of cancer, 1996, Volume: 73, Issue:9

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Body Weight; Carmustine; Cell Division; Cell Line; Dacarbazine; Glioblastoma; Guanine; Humans; Kinetics; Methyltransferases; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured

1996
O6-ethylguanine and O6-benzylguanine incorporated site-specifically in codon 12 of the rat H-ras gene induce semi-targeted as well as targeted mutations in Rat4 cells.
    Carcinogenesis, 1996, Volume: 17, Issue:4

    Topics: Animals; Base Sequence; Cell Line; Cell Line, Transformed; Clone Cells; Codon; DNA; Genes, ras; Guanine; Molecular Sequence Data; Mutation; Rats

1996
Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Aphidicolin; Carmustine; DNA Polymerase I; DNA Polymerase II; Drug Synergism; Enzyme Inhibitors; Female; Guanine; Humans; Male; Melphalan; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Rhabdomyosarcoma; Zalcitabine

1996
Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:12

    Topics: Animals; Antineoplastic Agents; Biotransformation; Cytosol; Guanine; Half-Life; In Vitro Techniques; Injections, Intravenous; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Sprague-Dawley; Tissue Distribution

1995
Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.
    Blood, 1996, Sep-01, Volume: 88, Issue:5

    Topics: Adult; Antigens, CD34; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bone Marrow Cells; Carmustine; Cells, Cultured; Colony-Forming Units Assay; Culture Media, Conditioned; DNA Damage; DNA Repair; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Guanine; Hematopoietic Stem Cells; Humans; Interleukin-3; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Stem Cell Factor

1996
Determination of O6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1996, Jun-07, Volume: 681, Issue:2

    Topics: Acetonitriles; Antineoplastic Agents; Buffers; Chromatography, High Pressure Liquid; Guanine; Humans; Hydrogen-Ion Concentration; Methanol; Phosphates; Quality Control

1996
Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a "salt-link".
    Biochemistry, 1996, Sep-24, Volume: 35, Issue:38

    Topics: Alkylating Agents; Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Blotting, Western; Cells, Cultured; Cysteine; DNA Repair; Epitope Mapping; Guanine; Humans; Hydrocarbons, Iodinated; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Precipitin Tests; Protein Conformation; Recombinant Fusion Proteins; Serine Endopeptidases

1996
Cytotoxicity of fluoroethylating agents is potentiated by O6-benzylguanine.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:7

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; Drug Synergism; Guanine; HeLa Cells; Humans; Iodoacetamide; Lomustine; Nimustine

1996
3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity.
    British journal of cancer, 1996, Volume: 74, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Benzamides; Carmustine; Dacarbazine; DNA Repair; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Guanine; Humans; Neoplasms; Temozolomide; Tumor Cells, Cultured

1996
In vitro inactivation of human O6-alkylguanine DNA alkyltransferase by antitumor triazene compounds.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Dacarbazine; DNA; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Spodoptera; Temozolomide; Triazenes; Tumor Cells, Cultured

1996
O6-methylguanine induces intrachromosomal homologous recombination in human cells.
    Carcinogenesis, 1996, Volume: 17, Issue:10

    Topics: Cells, Cultured; Cinnamates; DNA Adducts; Gene Conversion; Guanine; Humans; Hygromycin B; Methylnitronitrosoguanidine; Recombination, Genetic; Thymidine Kinase

1996
Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase.
    Gene therapy, 1996, Volume: 3, Issue:10

    Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line; Cricetinae; Cricetulus; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Humans; Mammals; Methyltransferases; Mutagenesis, Site-Directed; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase

1996
Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Nov-26, Volume: 93, Issue:24

    Topics: Animals; Antigens, CD34; Antineoplastic Agents; Carmustine; Cell Line; Cell Survival; CHO Cells; Cricetinae; DNA Primers; Dose-Response Relationship, Drug; Drug Resistance; Guanine; Humans; Leukemia, Erythroblastic, Acute; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombinant Proteins; Transfection

1996
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
    Cancer research, 1996, Dec-01, Volume: 56, Issue:23

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay

1996
Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.
    Cancer research, 1996, Dec-15, Volume: 56, Issue:24

    Topics: Arginine; Codon; DNA; Escherichia coli; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation

1996
Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer chemotherapy and pharmacology, 1997, Volume: 39, Issue:4

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Injections, Intra-Arterial; Rats; Rats, Nude; Transferases; Transplantation, Heterologous

1997
Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents.
    Mutation research, 1997, Feb-03, Volume: 373, Issue:2

    Topics: Alkylating Agents; Animals; Cell Division; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Enzyme Inhibitors; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Thioguanine

1997
O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow.
    Blood, 1997, Mar-01, Volume: 89, Issue:5

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Carmustine; Cell Division; Dacarbazine; Drug Synergism; Female; Guanine; Hematopoietic Stem Cells; Male; Mice; Temozolomide

1997
Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases.
    The Journal of biological chemistry, 1997, Mar-28, Volume: 272, Issue:13

    Topics: Amino Acid Sequence; Bacterial Proteins; Chromatography, High Pressure Liquid; DNA Repair; Escherichia coli; Escherichia coli Proteins; Guanine; Humans; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Peptide Fragments; Sodium Chloride

1997
Role of O6-methylguanine-DNA methyltransferase, glutathione transferase M3-3 and glutathione in resistance to carmustine in a human non-small cell lung cancer cell line.
    European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Carmustine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glutathione; Glutathione Transferase; Guanine; Humans; Lung Neoplasms; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1997
Creation of human alkyltransferases resistant to O6-benzylguanine.
    Cancer research, 1997, May-15, Volume: 57, Issue:10

    Topics: Binding Sites; Carcinogens; Drug Resistance; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transformation, Genetic

1997
[Study on potentiation of nitrosourea-cytotoxicity by DNA repair enzyme inhibitors in human brain tumor cells].
    No to shinkei = Brain and nerve, 1997, Volume: 49, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Glioma; Guanine; Humans; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Tumor Cells, Cultured

1997
Effect of single and multiple administration of an O6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model.
    Cancer chemotherapy and pharmacology, 1997, Volume: 40, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Administration Schedule; Guanine; Humans; Melanoma, Experimental; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured

1997
Effect of DNA on the inactivation of O6-alkylguanine-DNA alkyltransferase by 9-substituted O6-benzylguanine derivatives.
    Biochemical pharmacology, 1997, May-15, Volume: 53, Issue:10

    Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Line; DNA; Enzyme Inhibitors; Guanine; Hemocyanins; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding

1997
O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
    Cancer research, 1997, Nov-01, Volume: 57, Issue:21

    Topics: Animals; Antineoplastic Agents; Carmustine; Colonic Neoplasms; DNA Repair; Drug Resistance, Neoplasm; Female; Guanine; Humans; Mice; Mice, Nude; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured

1997
The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons.
    Biochimica et biophysica acta, 1997, Sep-26, Volume: 1342, Issue:1

    Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Calorimetry; Escherichia coli; Escherichia coli Proteins; Glycine; Guanine; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Protein Conformation; Recombinant Proteins; Thermodynamics; Transcription Factors

1997
Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Cancer research, 1997, Nov-15, Volume: 57, Issue:22

    Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Drug Resistance, Neoplasm; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transfection

1997
Substrate specificity of human O6-methylguanine-DNA methyltransferase for O6-benzylguanine derivatives in oligodeoxynucleotides.
    Chemical research in toxicology, 1997, Volume: 10, Issue:11

    Topics: Antineoplastic Agents; DNA; Guanine; Humans; Magnetic Resonance Spectroscopy; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotides; Substrate Specificity

1997
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells.
    Cancer research, 1998, Jan-01, Volume: 58, Issue:1

    Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; DNA Repair; Guanine; HeLa Cells; Humans; Lomustine; Methylation; O(6)-Methylguanine-DNA Methyltransferase

1998
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.
    The Journal of clinical investigation, 1998, Feb-15, Volume: 101, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bilirubin; Camptothecin; Causality; Crigler-Najjar Syndrome; Glucuronosyltransferase; Guanine; Humans; Irinotecan; Isoenzymes; Microsomes, Liver; Nitrophenols; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Uridine Diphosphate; Zidovudine

1998
Heterogeneity of O6-alkylguanine-DNA-alkyltransferase measured by flow cytometric analysis in blood and bone marrow mononuclear cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Bone Marrow Cells; Cell Membrane Permeability; Cell Separation; CHO Cells; Cricetinae; Enzyme Activation; Flow Cytometry; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Sensitivity and Specificity

1998
Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides.
    The Journal of biological chemistry, 1998, May-01, Volume: 273, Issue:18

    Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Guanine; Humans; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Point Mutation

1998
Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with inhibitors of poly(ADP-ribose) polymerase.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzamides; Dacarbazine; Enzyme Inhibitors; Guanine; HL-60 Cells; Humans; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Protein p53

1998
Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.
    Cancer research, 1998, May-01, Volume: 58, Issue:9

    Topics: Colony Count, Microbial; DNA Primers; DNA, Bacterial; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Genes, Bacterial; Genomic Library; Guanine; Humans; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotides, Antisense; Plasmids; Point Mutation

1998
O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
    Biochemical pharmacology, 1998, May-15, Volume: 55, Issue:10

    Topics: Animals; Carboxylic Ester Hydrolases; Cells, Cultured; Enzyme Inhibitors; Esters; Guanine; Humans; Hydrolysis; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Swine; Tumor Cells, Cultured

1998
Modulation of O6-alkylating agent induced clastogenicity by enhanced DNA repair capacity of bone marrow cells.
    Mutation research, 1998, Aug-07, Volume: 416, Issue:1-2

    Topics: Alkyl and Aryl Transferases; Alkylating Agents; Animals; Bone Marrow Cells; Bone Marrow Transplantation; DNA Repair; Drug Synergism; Enzyme Inhibitors; Female; Gene Expression; Guanine; Humans; Male; Mice; Micronucleus Tests; Mutagens; Mutation; Nitrosourea Compounds; Organophosphorus Compounds; Streptozocin

1998
Effects of O6-benzylguanine on growth and differentiation of P19 embryonic carcinoma cells treated with alkylating agents.
    Teratogenesis, carcinogenesis, and mutagenesis, 1998, Volume: 18, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Cell Survival; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tretinoin; Tumor Cells, Cultured

1998
Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase.
    Biochemistry, 1998, Sep-08, Volume: 37, Issue:36

    Topics: Alanine; Amino Acid Sequence; DNA Repair; DNA-Binding Proteins; Enzyme Activation; Glutamic Acid; Guanine; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Phenylalanine; Protein Conformation; Recombinant Proteins; Threonine; Tyrosine

1998
Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.
    Gene therapy, 1998, Volume: 5, Issue:6

    Topics: Antigens, CD34; Antineoplastic Agents, Alkylating; Cell Line; Cell Survival; Dacarbazine; Gene Transfer Techniques; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Humans; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Retroviridae; Temozolomide

1998
Retroviral transfer of a bacterial alkyltransferase gene (ada) into human bone marrow cells protects against O6-benzylguanine plus 1, 3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:2

    Topics: 3T3 Cells; Adolescent; Adult; Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Carmustine; Cell Survival; Female; Genetic Vectors; Guanine; Humans; Infant, Newborn; Male; Mice; Protective Agents; Retroviridae; Stem Cells; Transduction, Genetic

1997
Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Bacterial Proteins; Bone Marrow; Carmustine; Enzyme Inhibitors; Escherichia coli Proteins; Ethylnitrosourea; Feasibility Studies; Gene Transfer Techniques; Guanine; Mice; Mice, Inbred CBA; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transcription Factors

1995
Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Temozolomide; Tumor Cells, Cultured

1996
Pharmacokinetics of O6-benzylguanine and its active metabolite 8-oxo-O6-benzylguanine in plasma and cerebrospinal fluid after intrathecal administration of O6-benzylguanine in the nonhuman primate.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:11

    Topics: Animals; Antineoplastic Agents; Guanine; Injections, Spinal; Macaca mulatta; Male

1998
Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.
    Journal of medicinal chemistry, 1998, Dec-17, Volume: 41, Issue:26

    Topics: Enzyme Inhibitors; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Tumor Cells, Cultured

1998
Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; Drug Combinations; Drug Resistance, Neoplasm; Guanine; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic; Transfection; Tumor Cells, Cultured

1999
Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:1

    Topics: Animals; Antineoplastic Agents; Cattle; Codon; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Guanine; Humans; Mutation; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Polymorphism, Genetic

1999
Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.
    Carcinogenesis, 1999, Volume: 20, Issue:2

    Topics: 3T3 Cells; Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Base Pair Mismatch; Chromosomes, Human, Pair 2; DNA Methylation; DNA Repair; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Transfer Techniques; Genotype; Guanine; HeLa Cells; Humans; Melanoma, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Species Specificity; Tumor Cells, Cultured

1999
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Mar-30, Volume: 96, Issue:7

    Topics: Animals; Apoptosis; Cells, Cultured; Cisplatin; Dacarbazine; DNA Repair; DNA-Binding Proteins; Guanine; Intestinal Mucosa; Intestine, Small; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Mutagenesis; Mutagens; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Stem Cells; Temozolomide

1999
Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:3

    Topics: Alkyl and Aryl Transferases; Enzyme Inhibitors; Guanine; Humans; Leukocytes, Mononuclear

1999
Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA.
    Nucleic acids research, 1999, Apr-15, Volume: 27, Issue:8

    Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Repair; DNA, Complementary; Drosophila melanogaster; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thymine; Transcription Factors

1999
Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.
    British journal of cancer, 1999, Volume: 79, Issue:9-10

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Colony-Forming Units Assay; Drug Combinations; Drug Resistance, Neoplasm; Enzyme Inhibitors; Ethylnitrosourea; Fluorouracil; Guanine; Humans; Male; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Tumor Stem Cell Assay

1999
Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.
    Cancer research, 1999, Apr-01, Volume: 59, Issue:7

    Topics: Enzyme Inhibitors; Guanine; Histidine; Humans; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Tyrosine

1999
DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.
    Human gene therapy, 1999, Apr-10, Volume: 10, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow Transplantation; Carmustine; Cell Division; Colonic Neoplasms; Combined Modality Therapy; Drug Resistance, Neoplasm; Genetic Vectors; Guanine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transduction, Genetic

1999
Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
    Biochemical pharmacology, 1999, Jul-15, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; CHO Cells; Cricetinae; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase

1999
Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.
    Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carmustine; Drug Resistance, Neoplasm; Drug Synergism; Ethylnitrosourea; Glutathione; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1999
Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinoma; Ethylnitrosourea; Female; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Humans; Leukemia L1210; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Tumor Cells, Cultured

1999
Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.
    Biochemical pharmacology, 1999, Oct-15, Volume: 58, Issue:8

    Topics: Amino Acid Substitution; Antineoplastic Agents; Cells, Cultured; Codon; Drug Resistance; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase

1999
Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.
    Leukemia, 1999, Volume: 13, Issue:11

    Topics: Animals; Antineoplastic Agents; Carmustine; Cells, Cultured; Colony-Forming Units Assay; Drug Resistance, Neoplasm; Erythrocytes; Genetic Therapy; Granulocytes; Guanine; Hematopoietic Stem Cells; Humans; Immunohistochemistry; Macrophages; Male; Mice; Micronucleus Tests; Mutagens; Mutation; Nucleotidyltransferases; Spleen; Transduction, Genetic

1999
Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Enzyme Inhibitors; Female; Glioma; Guanine; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

1999
O(6)-benzylguanine enhances the in vitro immunotoxic activity of temozolomide on natural or antigen-dependent immunity.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3

    Topics: Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents, Alkylating; Cell Line; Dacarbazine; Enzyme Inhibitors; Guanine; Humans; Immunity, Cellular; Immunity, Innate; Immunosuppressive Agents; Interleukin-2; Monocytes; T-Lymphocytes, Regulatory; Temozolomide; Tumor Cells, Cultured

1999
Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy.
    Human gene therapy, 1999, Nov-20, Volume: 10, Issue:17

    Topics: Antineoplastic Agents; Carmustine; Cell Survival; Cloning, Molecular; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Stability; Gene Expression; Genetic Therapy; Guanine; Humans; K562 Cells; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transfection

1999
Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
    Carcinogenesis, 1999, Volume: 20, Issue:12

    Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Enzyme Inhibitors; Genes, ras; Guanine; Kinetics; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats

1999
O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.
    International journal of cancer, 2000, Jan-15, Volume: 85, Issue:2

    Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Guanine; Male; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Temozolomide; Transplantation, Heterologous

2000
Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:1

    Topics: Animals; Antineoplastic Agents; Brain; Carmustine; Drug Synergism; Guanine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley

2000
Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.
    The Biochemical journal, 2000, Apr-15, Volume: 347, Issue:Pt 2

    Topics: Amino Acid Sequence; Amino Acid Substitution; Antineoplastic Agents; Binding Sites; Conserved Sequence; DNA Repair; Drug Resistance; Escherichia coli; Gene Library; Guanine; Humans; Methylnitronitrosoguanidine; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Sequence Alignment

2000
Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.
    The Biochemical journal, 2000, Apr-15, Volume: 347, Issue:Pt 2

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antineoplastic Agents; Binding Sites; Carmustine; CHO Cells; Conserved Sequence; Cricetinae; DNA; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Humans; Lysine; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Sequence Alignment; Transfection

2000
In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.
    Carcinogenesis, 2000, Volume: 21, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Biotransformation; Cisplatin; Cytochrome P-450 Enzyme System; Dacarbazine; DNA Damage; Enzyme Inhibitors; Guanine; Intestine, Small; Methylnitrosourea; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

2000
Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines.
    Journal of cancer research and clinical oncology, 2000, Volume: 126, Issue:4

    Topics: Antineoplastic Agents, Alkylating; DNA Repair; Drug Interactions; Guanine; Humans; Lung Neoplasms; Platinum Compounds; Tumor Cells, Cultured; Vidarabine

2000
Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection.
    Blood, 2000, May-15, Volume: 95, Issue:10

    Topics: Animals; Antineoplastic Agents; Blood Cell Count; Carmustine; Cell Differentiation; Cell Division; Gene Transfer Techniques; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Mice; O(6)-Methylguanine-DNA Methyltransferase

2000
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:6

    Topics: Animals; Antineoplastic Agents; Carmustine; Central Nervous System Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous

2000
Role of O6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O6-alkylating agents.
    Journal of reproduction and fertility, 2000, Volume: 119, Issue:2

    Topics: Analysis of Variance; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; DNA Repair; Drug Resistance; Enzyme Inhibitors; Guanine; Half-Life; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Seminiferous Epithelium; Spermatogonia; Testis; Time Factors

2000
Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.
    Carcinogenesis, 2000, Volume: 21, Issue:7

    Topics: DNA Damage; DNA Repair; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Lac Operon; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Point Mutation; Substrate Specificity; Thymine

2000
Potentiation of BCNU anticancer activity by O6-benzylguanine: a study in vitro and in vivo.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2000, Volume: 19, Issue:1-2

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Cell Survival; Drug Synergism; Guanine; Humans; Injections, Subcutaneous; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured

2000
Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.
    Bone marrow transplantation, 2000, Volume: 25 Suppl 2

    Topics: Animals; Antineoplastic Agents; Carmustine; DNA Repair; Drug Resistance; Gene Expression; Genetic Therapy; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Leukemia L1210; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transduction, Genetic

2000
Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination.
    Cancer research, 2000, Aug-01, Volume: 60, Issue:15

    Topics: Alleles; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Codon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Genes, p53; Guanine; Homozygote; Humans; Loss of Heterozygosity; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Transcriptional Activation

2000
Can O6-alkylguanine-DNA alkyltransferase depletion enhance alkylator activity in the clinic?
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase

2000
Pharmacokinetics of oral O6-benzylguanine and evidence of interaction with oral ketoconazole in the rat.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:2

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; Biological Availability; Cytochrome P-450 CYP1A2; Guanine; Injections, Intravenous; Ketoconazole; Male; Mice; Rats; Rats, Sprague-Dawley

2000
Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and analogues in nonhuman primates.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:9

    Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Macaca mulatta; Male; Microsomes, Liver; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship

2000
Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: 3T3 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Gene Transfer Techniques; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Retroviridae; Transduction, Genetic

2000
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
    Cancer research, 2000, Oct-01, Volume: 60, Issue:19

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; CHO Cells; Cricetinae; Cyclophosphamide; Dacarbazine; Drug Interactions; Enzyme Inhibitors; Guanine; Mutagenicity Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

2000
O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
    Cancer research, 2000, Nov-15, Volume: 60, Issue:22

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Implants; Drug Synergism; Enzyme Inhibitors; Glioma; Gliosarcoma; Guanine; Humans; Male; Medulloblastoma; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344; Stereotaxic Techniques; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2001, Volume: 3, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, Alkylating; B-Lymphocytes; Blood Platelets; Blotting, Southern; Cell Culture Techniques; Dacarbazine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Female; Flow Cytometry; Genetic Vectors; Granulocytes; Green Fluorescent Proteins; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Hemoglobins; Luminescent Proteins; Mice; Mice, Inbred C57BL; Models, Genetic; Neutrophils; Plasmids; Retroviridae; T-Lymphocytes; Temozolomide; Time Factors

2001
Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Carmustine; Cell Survival; Drug Resistance; Enzyme Inhibitors; Enzyme Repression; Guanine; HT29 Cells; Humans; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Organophosphorus Compounds

2001
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Dacarbazine; Deoxyguanosine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured

2001
Purification and characterization of West Nile virus nucleoside triphosphatase (NTPase)/helicase: evidence for dissociation of the NTPase and helicase activities of the enzyme.
    Journal of virology, 2001, Volume: 75, Issue:7

    Topics: Acid Anhydride Hydrolases; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Chlorocebus aethiops; Guanine; Humans; Nucleoside-Triphosphatase; RNA Helicases; Vero Cells; West Nile virus

2001
Debenzylation of O(6)-benzyl-8-oxoguanine in human liver: implications for O(6)-benzylguanine metabolism.
    Biochemical pharmacology, 2001, Mar-15, Volume: 61, Issue:6

    Topics: Cytochrome P-450 CYP1A2; DNA, Complementary; Guanine; Humans; Isoenzymes; Liver

2001
Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT.
    International journal of cancer, 2001, Apr-01, Volume: 92, Issue:1

    Topics: Antineoplastic Agents; Azacitidine; Blotting, Southern; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Reactivators; Gene Amplification; Gene Expression; Guanine; Humans; Melanoma; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Promoter Regions, Genetic; Tumor Cells, Cultured

2001
Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9

    Topics: Amino Acid Sequence; Antineoplastic Agents; Carmustine; Cell Death; Cell Survival; Directed Molecular Evolution; Drug Resistance, Neoplasm; Enzyme Stability; Gene Library; Genetic Therapy; Guanine; Humans; K562 Cells; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transduction, Genetic

2001
Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:2

    Topics: Animals; Enzyme Inhibitors; Female; Fluorometry; Guanine; HeLa Cells; Humans; Kinetics; Male; Mice; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotides; Regeneration; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2001
O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells.
    Experimental hematology, 2001, Volume: 29, Issue:5

    Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Busulfan; Carmustine; Cell Line; CHO Cells; Coculture Techniques; Colony-Forming Units Assay; Cricetinae; Cricetulus; DNA Damage; DNA Repair; Erythroid Precursor Cells; Fibroblasts; Guanine; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Stromal Cells; Transfection

2001
Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.
    Chemical research in toxicology, 2001, Volume: 14, Issue:7

    Topics: Base Pair Mismatch; Colonic Neoplasms; Escherichia coli; Genetic Vectors; Guanine; Humans; Kidney; Lac Operon; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Transfection

2001
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
    Cancer research, 2001, Aug-01, Volume: 61, Issue:15

    Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines

2001
Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:8

    Topics: Biopsy; Blotting, Western; Enzyme Inhibitors; Guanine; Humans; Leukocytes, Mononuclear; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Time Factors

2001
The effectiveness of the O(6)-alkylguanine-DNA alkyltransferase encoded by the ogt(ST) gene from S. typhimurium in protection against alkylating drugs, resistance to O(6)-benzylguanine and sensitisation to dibromoalkane genotoxicity.
    Mutation research, 2001, Oct-18, Volume: 497, Issue:1-2

    Topics: Alkanes; Alkylating Agents; Amino Acid Sequence; Catalytic Domain; DNA Damage; Drug Resistance, Bacterial; Escherichia coli; Ethylene Dibromide; Genes, Bacterial; Guanine; Humans; Molecular Sequence Data; Mutagenicity Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Salmonella typhimurium; Sequence Homology, Amino Acid

2001
Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10

    Topics: Animals; Antineoplastic Agents; Biopsy; Carmustine; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Doxorubicin; Fenretinide; Guanine; Humans; Indoles; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Pyrroles; Tomography, X-Ray Computed; Treatment Outcome; Xenograft Model Antitumor Assays

2001
G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU.
    Journal of hematotherapy & stem cell research, 2001, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Brain; Carmustine; Cell Survival; Cell Transplantation; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Dystrophin; Flow Cytometry; Genetic Vectors; Green Fluorescent Proteins; Guanine; Humans; Infusions, Intravenous; Liver; Luminescent Proteins; Lung; Mesoderm; Mice; Mice, Inbred NOD; Mice, SCID; Mutation, Missense; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Retroviridae; Spleen; Stem Cells; Tissue Distribution; Transfection

2001
Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:12

    Topics: Antineoplastic Agents; Biotransformation; Carmustine; Cytochrome P-450 Enzyme System; Cytosol; Dacarbazine; DNA Repair; Guanine; Humans; Isoenzymes; Kinetics; Liver; Microsomes, Liver; Temozolomide

2001
[Mutation of human O6-alkylguanine-DNA alkyltransferase confers resistance to O6-benzylguanine].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2000, Volume: 22, Issue:4

    Topics: Amino Acid Sequence; Antineoplastic Agents; Base Sequence; DNA, Complementary; Drug Resistance, Neoplasm; Guanine; Humans; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation

2000
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine.
    Biochemistry, 2002, Jan-22, Volume: 41, Issue:3

    Topics: Antineoplastic Agents; Carcinogens; Deoxyribonucleotides; DNA Primers; DNA-Directed DNA Polymerase; Guanine; HIV Reverse Transcriptase; Kinetics; Substrate Specificity; Templates, Genetic

2002
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes.
    Biochemistry, 2002, Jan-22, Volume: 41, Issue:3

    Topics: Carcinogens; Deoxyribonucleotides; DNA Adducts; DNA Replication; DNA-Directed DNA Polymerase; Guanine; HIV Reverse Transcriptase; Kinetics; Models, Theoretical; Oligodeoxyribonucleotides; Recombinant Proteins; Substrate Specificity

2002
Biochemical changes associated with a multidrug-resistant phenotype of a human glioma cell line with temozolomide-acquired resistance.
    Biochemical pharmacology, 2002, Apr-01, Volume: 63, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Carrier Proteins; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dacarbazine; DNA Repair Enzymes; DNA-Binding Proteins; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Glioma; Guanine; Humans; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Phenotype; Proto-Oncogene Proteins c-bcl-2; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2002
Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine.
    Biochemical pharmacology, 2002, Apr-15, Volume: 63, Issue:8

    Topics: Amino Acid Sequence; Animals; Enzyme Inhibitors; Guanine; Humans; Mice; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats; Sequence Homology, Amino Acid; Species Specificity

2002
Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
    Cancer research, 2002, Jun-01, Volume: 62, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Base Pair Mismatch; Carmustine; Carrier Proteins; CHO Cells; Colonic Neoplasms; Cricetinae; DNA Repair; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Genes, p53; Guanine; Humans; Mutagenesis; Mutation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Tumor Cells, Cultured

2002
Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Dose-Response Relationship, Drug; Drug Implants; Drug Synergism; Guanine; Inflammation; Infusion Pumps, Implantable; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Necrosis; Parietal Lobe; Peritoneal Cavity

2002
Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
    Molecular cancer therapeutics, 2001, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Cycle; Cell Division; Chlorambucil; CHO Cells; Cricetinae; Enzyme Inhibitors; Guanine; Melphalan; O(6)-Methylguanine-DNA Methyltransferase; Phosphoramide Mustards

2001
O6-benzylguanine-mediated enhancement of chemotherapy.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:11

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Camptothecin; Carmustine; Central Nervous System Neoplasms; Cyclophosphamide; Dacarbazine; DNA; Enzyme Inhibitors; Female; Guanine; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Protein Synthesis Inhibitors; Temozolomide

2002
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase.
    Biochemistry, 2003, Feb-04, Volume: 42, Issue:4

    Topics: Binding Sites; Chlorides; DNA Repair; DNA-Binding Proteins; Enzyme Inhibitors; Enzyme Stability; Guanine; Humans; Mass Spectrometry; Metalloproteins; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Recombinant Proteins; Spectrometry, Fluorescence; Structure-Activity Relationship; Substrate Specificity; Zinc; Zinc Compounds

2003
Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity.
    Journal of neurosurgery, 2003, Volume: 98, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Cycle Proteins; Cell Survival; Colony-Forming Units Assay; Dacarbazine; G2 Phase; Glioma; Guanine; Humans; Mitosis; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Tumor Cells, Cultured

2003
Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells.
    Blood, 2003, Jul-15, Volume: 102, Issue:2

    Topics: Animals; beta-Thalassemia; Crosses, Genetic; Dacarbazine; Drug Resistance; Female; Genetic Vectors; Globins; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Selection, Genetic; Temozolomide; Transplantation Chimera; Transplantation Conditioning

2003
Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo.
    Chemistry & biology, 2003, Volume: 10, Issue:4

    Topics: Animals; CHO Cells; Cricetinae; Directed Molecular Evolution; DNA Primers; Fluorescent Dyes; Genes, Reporter; Guanine; Indicators and Reagents; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; O(6)-Methylguanine-DNA Methyltransferase; Peptide Library; Proteomics; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction

2003
Covalent and selective immobilization of fusion proteins.
    Journal of the American Chemical Society, 2003, Jul-02, Volume: 125, Issue:26

    Topics: Biosensing Techniques; Glutathione Transferase; Guanine; Kinetics; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Surface Plasmon Resonance

2003
Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2003, Volume: 8, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Blotting, Southern; Bone Marrow Cells; Bone Marrow Transplantation; Carmustine; Cell Separation; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Flow Cytometry; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Guanine; Humans; Mice; Mice, Inbred C3H; Models, Genetic; Mutation; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Stem Cells; Time Factors

2003
Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:4

    Topics: Animals; Annexin A5; Antineoplastic Agents, Alkylating; Apoptosis; Cell Cycle; Cell Survival; CHO Cells; Cricetinae; DNA, Neoplasm; Female; Flow Cytometry; Guanine; Half-Life; Ifosfamide; Kinetics; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Transfection

2003
Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:7

    Topics: Animals; Apoptosis; Carboplatin; Cell Division; CHO Cells; Cisplatin; Cricetinae; DNA Damage; DNA, Neoplasm; Drug Interactions; Drug Synergism; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured

2003
Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus.
    The Biochemical journal, 2003, Oct-15, Volume: 375, Issue:Pt 2

    Topics: Alkylating Agents; Archaeoglobus fulgidus; Bacteria; DNA; DNA Damage; DNA Repair; Enzyme Stability; Guanine; Hydrogen-Ion Concentration; O(6)-Methylguanine-DNA Methyltransferase; Protein Folding; Protein Renaturation; Temperature

2003
Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide.
    British journal of cancer, 2003, Sep-01, Volume: 89, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Cell Death; Cell Division; Dacarbazine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression; Glioma; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Telomerase; Temozolomide; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured

2003
Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients.
    Journal of hematotherapy & stem cell research, 2003, Volume: 12, Issue:4

    Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line; Cell Lineage; Cell Separation; Cloning, Molecular; Dose-Response Relationship, Drug; Flow Cytometry; Gene Silencing; Genetic Vectors; Genome; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Mice; Mice, Inbred C3H; Models, Genetic; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Retroviridae Proteins, Oncogenic; Stem Cells; Time Factors; Transgenes

2003
Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Carmustine; DNA Damage; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Guanine; Humans; Melanoma; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Tumor Cells, Cultured

2003
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Sep-01, Volume: 9, Issue:10 Pt 1

    Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarbazine; Deoxyguanosine; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Time Factors

2003
In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.
    The Journal of clinical investigation, 2003, Volume: 112, Issue:10

    Topics: Animals; Antigens, CD34; Antineoplastic Agents; Carmustine; Gene Transfer Techniques; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Lentivirus; Mice; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; Radiation; Severe Combined Immunodeficiency; Transduction, Genetic; Transgenes; Transplantation Conditioning

2003
Induced protein dimerization in vivo through covalent labeling.
    Journal of the American Chemical Society, 2003, Dec-10, Volume: 125, Issue:49

    Topics: Bacterial Proteins; Dimerization; Escherichia coli; Glutathione Transferase; Guanine; Humans; Methotrexate; O(6)-Methylguanine-DNA Methyltransferase; Receptors, Glucocorticoid; Recombinant Fusion Proteins; Serine Endopeptidases; Tetrahydrofolate Dehydrogenase; Transcriptional Activation; Yeasts

2003
Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide.
    Journal of neurosurgery, 2003, Volume: 99, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

2003
Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:12

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow; Brain Neoplasms; Carmustine; Glioma; Guanine; Humans; Mice; Mice, Inbred NOD; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; Transduction, Genetic; Transplantation, Heterologous

2003
In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 9, Issue:2

    Topics: Animals; Carmustine; Flow Cytometry; Gene Products, env; Genetic Vectors; Guanine; Hematopoietic Stem Cells; HIV-1; Humans; Lentivirus; Mice; Mice, Inbred NOD; Mice, SCID; O(6)-Methylguanine-DNA Methyltransferase; T-Lymphocytes; Transduction, Genetic; Virus Replication

2004
Labeling of fusion proteins of O6-alkylguanine-DNA alkyltransferase with small molecules in vivo and in vitro.
    Methods (San Diego, Calif.), 2004, Volume: 32, Issue:4

    Topics: Bacterial Proteins; Blotting, Western; Estrogen Receptor alpha; Fluorescein; Fluorescent Dyes; Fungal Proteins; Guanine; HeLa Cells; Humans; Methotrexate; Microscopy, Fluorescence; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Serine Endopeptidases; Staining and Labeling; Subcellular Fractions; Tamoxifen

2004
Interstitial infusion of carmustine in the rat brain stem with systemic administration of O6-benzylguanine.
    Journal of neuro-oncology, 2004, Volume: 67, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Stem; Carmustine; Guanine; Infusion Pumps; Injections, Intraperitoneal; Macrophages; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques

2004
Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 9, Issue:6

    Topics: Alkyl and Aryl Transferases; Cell Line; Gene Expression; Genetic Therapy; Genetic Vectors; Guanine; Humans; Lentivirus; Mutagenesis, Insertional; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Proviruses; Transduction, Genetic; Transgenes; Virus Integration

2004
Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection.
    Gene therapy, 2004, Volume: 11, Issue:22

    Topics: Animals; Antineoplastic Agents; Carmustine; Female; Ferrochelatase; Genetic Engineering; Genetic Therapy; Genetic Vectors; Guanine; Lentivirus; Male; Mice; Mice, Inbred BALB C; Models, Animal; O(6)-Methylguanine-DNA Methyltransferase; Protoporphyria, Erythropoietic; Stem Cell Transplantation; Stem Cells; Transduction, Genetic

2004
Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker.
    Experimental hematology, 2004, Volume: 32, Issue:8

    Topics: Animals; Cell Nucleus; Cells, Cultured; Genetic Vectors; Green Fluorescent Proteins; Guanine; Hematopoietic Stem Cells; Luminescent Proteins; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Transduction, Genetic

2004
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:9

    Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic

2004
Synthesis and antitumor activity of methyltriazene prodrugs simultaneously releasing DNA-methylating agents and the antiresistance drug O(6)-benzylguanine.
    Journal of medicinal chemistry, 2004, Dec-30, Volume: 47, Issue:27

    Topics: Antineoplastic Agents; Cell Line, Tumor; Dacarbazine; Diazomethane; DNA Methylation; Drug Resistance, Neoplasm; Guanine; Humans; Hydrolysis; Prodrugs; Temozolomide; Triazenes

2004
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
    Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biochemistry; Carmustine; Cattle; Cell Death; Deoxyguanosine; Drug Stability; Enzyme Activation; Escherichia coli; Glucuronidase; Guanine; HT29 Cells; Humans; Hydrolysis; Kinetics; Liver; Prodrugs

2005
Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
    Cancer chemotherapy and pharmacology, 2005, Volume: 55, Issue:4

    Topics: Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; DNA Damage; DNA Repair; Drug Synergism; Glutathione; Guanine; Humans; Platinum; Tumor Cells, Cultured

2005
Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU.
    Oncogene, 2005, Mar-24, Volume: 24, Issue:13

    Topics: Amino Acid Substitution; Carmustine; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; DNA Damage; Drug Resistance, Neoplasm; G2 Phase; Guanine; Humans; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase

2005
O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Apr-01, Volume: 11, Issue:7

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain; Carmustine; Cell Survival; Child; Child, Preschool; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Female; Guanine; Humans; Male; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Tumor Cells, Cultured

2005
Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
    Cancer research, 2005, Apr-15, Volume: 65, Issue:8

    Topics: Antigens, CD34; Antineoplastic Agents, Alkylating; Carmustine; Cell Death; Cell Nucleus; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Methyl Methanesulfonate; Mitochondria; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transfection

2005
Role of O6-methylguanine-DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines.
    Oral oncology, 2005, Volume: 41, Issue:10

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cisplatin; DNA Repair; Docetaxel; Drug Resistance, Neoplasm; Guanine; Humans; Methylnitronitrosoguanidine; Mouth Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Taxoids

2005
Role of GADD34 in modulation of cisplatin cytotoxicity.
    Biochemical pharmacology, 2006, Jan-12, Volume: 71, Issue:3

    Topics: Antigens, Differentiation; Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cisplatin; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; Guanine; Humans; Oligonucleotide Array Sequence Analysis; Protein Phosphatase 1; Reverse Transcriptase Polymerase Chain Reaction

2006
[O6-benzylguanine stimulates regulatory functions of the Ada protein in Escherichia coli].
    Genetika, 2005, Volume: 41, Issue:11

    Topics: DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Guanine; Humans; Mixed Function Oxygenases; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Transcription Factors

2005
The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.
    Oncology research, 2005, Volume: 15, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Cell Line; Cells, Cultured; CHO Cells; Cricetinae; Drug Synergism; Guanine; HL-60 Cells; Humans; Hydrazines; Isocyanates; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Sulfonamides; Transfection

2005
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:1

    Topics: Alkylating Agents; Carmustine; Dacarbazine; Drug Resistance; Genetic Engineering; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic

2006
Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.
    Nuclear medicine and biology, 2006, Volume: 33, Issue:3

    Topics: Animals; Benzoflavones; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; Guanine; Humans; Iodine Radioisotopes; Male; Medulloblastoma; Mice; Mice, Inbred BALB C; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Radionuclide Imaging; Rhabdomyosarcoma; Transplantation, Heterologous; Tumor Cells, Cultured

2006
Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling.
    Protein engineering, design & selection : PEDS, 2006, Volume: 19, Issue:7

    Topics: Binding Sites; Cell Membrane; Cells, Cultured; Escherichia coli; Evolution, Molecular; Guanine; Models, Molecular; Molecular Weight; Mutagenesis, Site-Directed; O(6)-Methylguanine-DNA Methyltransferase; Peptide Library; Recombinant Fusion Proteins; Staining and Labeling

2006
In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo.
    Journal of hepatology, 2006, Volume: 45, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Differentiation; Cell Line; Dacarbazine; Drug Resistance; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Hepatocytes; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic; Transplantation, Heterologous

2006
Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Aug-01, Volume: 12, Issue:15

    Topics: Animals; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; DNA Damage; Glioblastoma; Guanine; Humans; Methylation; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Temozolomide; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2006
Fluorophores for live cell imaging of AGT fusion proteins across the visible spectrum.
    BioTechniques, 2006, Volume: 41, Issue:2

    Topics: Animals; Cell Line; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Guanine; Image Processing, Computer-Assisted; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Rhodamines

2006
A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system.
    International journal of oncology, 2006, Volume: 29, Issue:4

    Topics: Antineoplastic Agents; Base Pair Mismatch; Dacarbazine; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Temozolomide; Tumor Cells, Cultured; Up-Regulation

2006
Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma.
    Journal of neuro-oncology, 2007, Volume: 82, Issue:1

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance; Enzyme Inhibitors; Glioblastoma; Guanine; Humans; Infusions, Intralesional; Male; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins

2007
Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
    Carcinogenesis, 2007, Volume: 28, Issue:5

    Topics: Alkylating Agents; Animals; Carmustine; Cell Line, Tumor; Cyclophosphamide; Dacarbazine; Guanine; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transfection

2007
The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents.
    Journal of molecular medicine (Berlin, Germany), 2007, Volume: 85, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Curcumin; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Group F Protein; Fanconi Anemia Complementation Group Proteins; Glioma; Guanine; Humans; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Temozolomide; Time Factors; Transfection; Tumor Suppressor Proteins; Ubiquitins

2007
Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing.
    The Journal of biological chemistry, 2007, May-04, Volume: 282, Issue:18

    Topics: Archaeal Proteins; Base Pair Mismatch; Base Pairing; Crystallography, X-Ray; Deoxyribonucleotides; DNA Polymerase beta; DNA Replication; DNA-Directed DNA Polymerase; DNA, Archaeal; Guanine; HIV Reverse Transcriptase; Humans; Kinetics; Mass Spectrometry; Sulfolobus solfataricus

2007
Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines.
    Oncology reports, 2007, Volume: 17, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorouracil; Guanine; Humans; Mouth Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

2007
Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression.
    Blood, 2007, Sep-15, Volume: 110, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bone Marrow Cells; Bone Marrow Transplantation; Carmustine; Cell Differentiation; Genetic Therapy; Guanine; Hematopoiesis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells; O(6)-Methylguanine-DNA Methyltransferase; Stem Cells; Terminal Repeat Sequences; Transduction, Genetic; Transplantation, Homologous

2007
A concise synthesis of the Pennsylvania Green fluorophore and labeling of intracellular targets with O6-benzylguanine derivatives.
    Organic letters, 2007, Sep-13, Volume: 9, Issue:19

    Topics: Alkyl and Aryl Transferases; Animals; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Fluorescent Dyes; Genes, Reporter; Guanine; Humans; Models, Molecular; Molecular Probes; Molecular Structure

2007
Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Sep-15, Volume: 13, Issue:18 Pt 1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Irinotecan; Mice; Mice, SCID; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neuroblastoma; Nuclear Proteins; Temozolomide; Tumor Suppressor Proteins

2007
O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:10

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Base Pair Mismatch; Blotting, Western; Dacarbazine; DNA Methylation; DNA Mismatch Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Fibroblast Growth Factor 2; Guanine; Humans; Luciferases; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Skin Neoplasms; Temozolomide; Tumor Cells, Cultured

2007
Caged substrates for protein labeling and immobilization.
    Chembiochem : a European journal of chemical biology, 2008, Jan-04, Volume: 9, Issue:1

    Topics: Dimerization; Electrophoresis, Polyacrylamide Gel; Enzymes, Immobilized; Fluorescence; Fluorescent Dyes; Glutathione Transferase; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Photolysis; Protein Binding; Recombinant Proteins; Staining and Labeling

2008
Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance.
    Molecular pharmacology, 2008, Volume: 74, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cadmium Chloride; Carmustine; Cell Line, Tumor; Cell Proliferation; Comet Assay; Dacarbazine; DNA Mismatch Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Guanine; Humans; Hydroxylamines; Nimustine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temozolomide

2008
Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase.
    Cancer investigation, 2008, Volume: 26, Issue:6

    Topics: Alkylating Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethacrynic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutathione S-Transferase pi; Glutathione Transferase; Guanine; Humans; Melphalan; Promoter Regions, Genetic; Tumor Suppressor Proteins

2008
Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:2

    Topics: Antineoplastic Agents; Caspase 12; Caspase 3; Cell Line, Tumor; Cisplatin; DNA; DNA Breaks, Double-Stranded; Drug Synergism; Endoplasmic Reticulum; Guanine; Humans; Platinum; RNA, Messenger; Transcription Factor CHOP

2008
Development of an O(6)-alkylguanine-DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-3H]O(6)-benzylguanine to the protein.
    Analytical biochemistry, 2008, Dec-01, Volume: 383, Issue:1

    Topics: Blotting, Western; Cell Line; Enzyme Assays; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Proteins; Reproducibility of Results

2008
Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Computer Simulation; Enzyme Inhibitors; Guanine; Humans; Hydrogen Bonding; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase; Stereoisomerism; Structure-Activity Relationship

2008
Role of copper transporters in resistance to platinating agents.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:1

    Topics: Adenosine Triphosphatases; Antineoplastic Agents; Biological Transport; Carboplatin; Cation Transport Proteins; Cell Line; Cisplatin; Copper Transporter 1; Copper-Transporting ATPases; Drug Resistance, Neoplasm; Fibroblasts; Gene Expression Regulation; Guanine; Humans; Organoplatinum Compounds; Oxaliplatin

2009
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.
    Cancer research, 2008, Dec-01, Volume: 68, Issue:23

    Topics: Alkylating Agents; Amino Acid Sequence; Animals; BRCA2 Protein; DNA Repair; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Mice; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase

2008
Indo-1 derivatives for local calcium sensing.
    ACS chemical biology, 2009, Mar-20, Volume: 4, Issue:3

    Topics: Animals; Calcium; Cell Nucleus; Fluorescent Dyes; Guanine; Indoles; Mice; Microscopy, Fluorescence; Muscle Fibers, Skeletal; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins

2009
The alkyltransferase-like ybaZ gene product enhances nucleotide excision repair of O(6)-alkylguanine adducts in E. coli.
    DNA repair, 2009, Jun-04, Volume: 8, Issue:6

    Topics: Adenosine Triphosphatases; Alkyl and Aryl Transferases; DNA Adducts; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Guanine; Mutagenesis; Mutation; Rifampin

2009
Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.
    Stem cells (Dayton, Ohio), 2009, Volume: 27, Issue:5

    Topics: Animals; Animals, Genetically Modified; Antigens, CD34; Carmustine; Cell Differentiation; Cell Separation; Cell Survival; Drug Resistance; Guanine; Humans; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; O(6)-Methylguanine-DNA Methyltransferase; Regeneration; Retroviridae; Stem Cell Transplantation; Transduction, Genetic

2009
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
    The Journal of clinical investigation, 2009, Volume: 119, Issue:7

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Dacarbazine; Genetic Therapy; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Homeodomain Proteins; Lentivirus; Macaca mulatta; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide

2009
Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases.
    Chembiochem : a European journal of chemical biology, 2009, Oct-12, Volume: 10, Issue:15

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Binding, Competitive; Guanine; Humans; Ligands; O(6)-Methylguanine-DNA Methyltransferase; Protein Kinase Inhibitors; src Homology Domains

2009
Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.
    Radiation research, 2009, Volume: 172, Issue:4

    Topics: Cell Division; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Mismatch Repair; Drug Resistance, Neoplasm; Enzyme Activation; G2 Phase; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Radiation Dosage; Radiation Tolerance; Temozolomide

2009
Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Oct-01, Volume: 15, Issue:19

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Proliferation; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Drug Evaluation, Preclinical; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Genes, p53; Guanine; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Pancreatic Neoplasms; Tumor Suppressor Proteins

2009
Effect of O6-chloroethylguanine DNA lesions on the kinetics and mechanism of micronucleus induction in vivo.
    Environmental and molecular mutagenesis, 2010, Volume: 51, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Guanine; Kinetics; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; O(6)-Methylguanine-DNA Methyltransferase; Toxicity Tests

2010
Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:7

    Topics: Animals; Carmustine; Genetic Therapy; Guanine; Hematopoietic Stem Cell Transplantation; Macaca nemestrina; Male; O(6)-Methylguanine-DNA Methyltransferase; Papio; Retroviridae; Stem Cells; Transgenes

2010
Thin layer chromatography-based assay of O6-methylguanine-DNA methyltransferase activity in tissue.
    Analytical biochemistry, 2010, Oct-15, Volume: 405, Issue:2

    Topics: Cell Line, Tumor; Chromatography, Thin Layer; Fluorescent Dyes; Guanine; Humans; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase

2010
Localizable and highly sensitive calcium indicator based on a BODIPY fluorophore.
    Analytical chemistry, 2010, Aug-01, Volume: 82, Issue:15

    Topics: Animals; Boron Compounds; Calcium; CHO Cells; Cricetinae; Cricetulus; Fluorescent Dyes; Glycine; Guanine; Indicators and Reagents; Microscopy, Fluorescence; Purines

2010
Quenched substrates for live-cell labeling of SNAP-tagged fusion proteins with improved fluorescent background.
    Analytical chemistry, 2010, Oct-01, Volume: 82, Issue:19

    Topics: Animals; Escherichia coli; Fluorescent Dyes; Guanine; Humans; Mice; Microscopy, Fluorescence; NIH 3T3 Cells; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; STAT5 Transcription Factor

2010
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.
    The Journal of biological chemistry, 2010, Dec-24, Volume: 285, Issue:52

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mechanistic Target of Rapamycin Complex 1; Methylnitronitrosoguanidine; Multiprotein Complexes; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

2010
Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2010, Volume: 10, Issue:5

    Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Mismatch Repair; Fibroblasts; Guanine; Humans; In Situ Nick-End Labeling; Mice; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Tumor Suppressor Protein p53

2010
Radioiodinated O(6)-Benzylguanine derivatives containing an azido function.
    Nuclear medicine and biology, 2011, Volume: 38, Issue:1

    Topics: 3-Iodobenzylguanidine; Azides; Cell Line, Tumor; Guanine; Humans; Iodine Radioisotopes; Nuclear Localization Signals; O(6)-Methylguanine-DNA Methyltransferase; Radiochemistry

2011
Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-15, Volume: 17, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Cells; Cell Line, Tumor; Cord Blood Stem Cell Transplantation; Dacarbazine; Dose-Response Relationship, Drug; Female; Glioblastoma; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Survival Analysis; Temozolomide; Transplantation Chimera; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays

2011
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
    Journal of medicinal chemistry, 2011, Nov-10, Volume: 54, Issue:21

    Topics: Animals; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Line, Tumor; DNA; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Hydrazines; Mice; NADPH-Ferrihemoprotein Reductase; O(6)-Methylguanine-DNA Methyltransferase; Prodrugs; Solubility; Structure-Activity Relationship; Sulfonamides; Xanthine Oxidase

2011
SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells.
    Bioconjugate chemistry, 2011, Dec-21, Volume: 22, Issue:12

    Topics: Cell Line, Tumor; Chlorophyllides; Drug Delivery Systems; ErbB Receptors; Gene Expression; Guanine; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Porphyrins; Recombinant Fusion Proteins; Single-Chain Antibodies

2011
Releasable SNAP-tag probes for studying endocytosis and recycling.
    ACS chemical biology, 2012, Mar-16, Volume: 7, Issue:3

    Topics: Cell Line; Cell Survival; Endocytosis; Endosomes; Fluorescent Dyes; Guanine; HEK293 Cells; HeLa Cells; Humans; Membrane Proteins; O(6)-Methylguanine-DNA Methyltransferase

2012
SNAP-tag based proteomics approach for the study of the retrograde route.
    Traffic (Copenhagen, Denmark), 2012, Volume: 13, Issue:7

    Topics: Animals; Endocytosis; Guanine; HeLa Cells; Humans; Mass Spectrometry; Membrane Proteins; Protein Transport; Proteome; Proteomics; Receptors, Transferrin; Shiga Toxin; SNARE Proteins

2012
MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
    Molecular medicine (Cambridge, Mass.), 2012, Sep-07, Volume: 18

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Guanine; Humans; Immunohistochemistry; Mice; Mice, Nude; Phosphorylation; Phosphoserine; Promoter Regions, Genetic; Protein Binding; Tamoxifen; Transcription, Genetic; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2012
A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.
    Chemical biology & drug design, 2012, Volume: 80, Issue:2

    Topics: Antineoplastic Agents; Cell Hypoxia; Cell Line; Enzyme Inhibitors; Guanine; HL-60 Cells; Humans; Hydrazines; Hydrogen Peroxide; O(6)-Methylguanine-DNA Methyltransferase; Oxidation-Reduction; Oxygen; Purines; Sulfonamides; Superoxides

2012
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Animals; Carcinogens; Deoxyguanosine; DNA Adducts; Enzyme Inhibitors; Female; Guanine; Lung; Lung Neoplasms; Mice; Mutagens; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines

2012
Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:3

    Topics: Animals; Antineoplastic Agents; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Guanine; Humans; Mammary Neoplasms, Experimental; Mice; Mutation; Tumor Cells, Cultured; Tumor Suppressor Proteins

2014
Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Cell Line, Tumor; Drug Design; Enzyme Inhibitors; Guanine; Humans; Magnetic Resonance Spectroscopy; O(6)-Methylguanine-DNA Methyltransferase; Oxidation-Reduction; Prodrugs

2013
Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, May-15, Volume: 19, Issue:10

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Dacarbazine; DNA Damage; DNA Methylation; DNA, Mitochondrial; fas Receptor; Gene Expression Profiling; Guanine; Histones; Humans; Membrane Potential, Mitochondrial; Myeloid Progenitor Cells; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotide Array Sequence Analysis; Signal Transduction; Temozolomide; Tumor Suppressor Protein p53

2013
Tolerance of base pair size and shape in postlesion DNA synthesis.
    Journal of the American Chemical Society, 2013, May-01, Volume: 135, Issue:17

    Topics: Base Pair Mismatch; Base Pairing; Catalysis; DNA Adducts; DNA Damage; DNA Polymerase beta; DNA Primers; DNA Replication; Guanine; Guanosine Triphosphate; Kinetics; Models, Molecular; Sulfolobus solfataricus; Thermus

2013
MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NFκB and mutant p53.
    Neurological research, 2013, Volume: 35, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Guanine; Humans; Mutation; NF-kappa B; Temozolomide; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2013
Targeted delivery of dendritic polyglycerol-doxorubicin conjugates by scFv-SNAP fusion protein suppresses EGFR+ cancer cell growth.
    Biomacromolecules, 2013, Aug-12, Volume: 14, Issue:8

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Dendrimers; Doxorubicin; Drug Delivery Systems; Drug Screening Assays, Antitumor; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Recombinant Fusion Proteins; Single-Chain Antibodies

2013
Cationic core-shell nanoparticles with carmustine contained within O⁶-benzylguanine shell for glioma therapy.
    Biomaterials, 2013, Volume: 34, Issue:35

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cations; Cell Line, Tumor; Chemical Phenomena; Disease Models, Animal; Drug Delivery Systems; Female; Glioblastoma; Guanine; Magnetic Resonance Imaging; Male; Nanoparticles; Rats; Rats, Inbred F344

2013
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
    Chemical research in toxicology, 2013, Nov-18, Volume: 26, Issue:11

    Topics: Animals; Butadienes; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; DNA Adducts; DNA Mutational Analysis; Epoxy Compounds; Ethylene Dibromide; Glutathione; Glutathione Transferase; Guanine; Liver; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation; Mutation Rate; O(6)-Methylguanine-DNA Methyltransferase; Spectrometry, Mass, Electrospray Ionization

2013
Cell-permeant and photocleavable chemical inducer of dimerization.
    Angewandte Chemie (International ed. in English), 2014, Apr-25, Volume: 53, Issue:18

    Topics: Cell Membrane; Cell Membrane Permeability; Cytosol; Endocytosis; Golgi Apparatus; Green Fluorescent Proteins; Guanine; HeLa Cells; Humans; Kinetics; Light; Lysosomes; Mitochondria; Photosensitizing Agents; Protein Multimerization; Protein Transport; Recombinant Fusion Proteins

2014
Lentiviral MGMT(P140K)-mediated in vivo selection employing a ubiquitous chromatin opening element (A2UCOE) linked to a cellular promoter.
    Biomaterials, 2014, Volume: 35, Issue:25

    Topics: Animals; Antineoplastic Agents; Chromatin; Cloning, Molecular; DNA Copy Number Variations; Female; Gene Expression; Genetic Therapy; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Lentivirus; Mice; Mice, Inbred C57BL; O(6)-Methylguanine-DNA Methyltransferase; Phosphoglycerate Kinase; Promoter Regions, Genetic; Sequence Analysis, DNA; Transgenes

2014
Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tand
    Chemical research in toxicology, 2014, Jul-21, Volume: 27, Issue:7

    Topics: Alkylating Agents; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyguanosine; DNA; DNA Damage; Ethylnitrosourea; Glioma; Guanine; Humans; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014
Complex conformational heterogeneity of the highly flexible O6-benzyl-guanine DNA adduct.
    Chemical research in toxicology, 2014, Jul-21, Volume: 27, Issue:7

    Topics: DNA Adducts; Guanine; Molecular Docking Simulation; Nucleic Acid Conformation

2014
Exo1 independent DNA mismatch repair involves multiple compensatory nucleases.
    DNA repair, 2014, Volume: 21

    Topics: Animals; Cell Line; Dacarbazine; DNA Mismatch Repair; DNA Repair Enzymes; DNA-Binding Proteins; Endodeoxyribonucleases; Endonucleases; Exodeoxyribonucleases; Fibroblasts; Guanine; Mice; Mice, Inbred C57BL; MRE11 Homologue Protein; Multifunctional Enzymes; Nuclear Proteins; Temozolomide; Up-Regulation

2014
Controlled assembly of SNAP-PNA-fluorophore systems on DNA templates to produce fluorescence resonance energy transfer.
    Bioconjugate chemistry, 2014, Oct-15, Volume: 25, Issue:10

    Topics: DNA; Electrophoresis, Polyacrylamide Gel; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Guanine; O(6)-Methylguanine-DNA Methyltransferase; Peptide Nucleic Acids; Staining and Labeling

2014
Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumors.
    ACS nano, 2014, Oct-28, Volume: 8, Issue:10

    Topics: Animals; Brain Neoplasms; Glioblastoma; Guanine; Magnetic Resonance Imaging; Magnetics; Mice; Mice, Nude; Nanoparticles; Oxidation-Reduction

2014
O6-alkylguanine postlesion DNA synthesis is correct with the right complement of hydrogen bonding.
    ACS chemical biology, 2014, Dec-19, Volume: 9, Issue:12

    Topics: Archaeal Proteins; Base Pairing; DNA Adducts; DNA Damage; DNA Polymerase beta; DNA Repair; DNA Replication; DNA, Archaeal; Gene Expression; Guanine; Hydrogen Bonding; Recombinant Proteins; Sulfolobus solfataricus

2014
Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance.
    Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:1

    Topics: Aldehyde Oxidase; Catechin; Cytochrome P-450 Enzyme System; Diet; Enzyme Inhibitors; Food-Drug Interactions; Guanine; Humans; Ligands; Oxidation-Reduction; Quantitative Structure-Activity Relationship; Tea; Xenobiotics

2015
MGMT inhibition suppresses survivin expression in pancreatic cancer.
    Pancreas, 2015, Volume: 44, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Deoxycytidine; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Gemcitabine; Gene Expression Regulation, Neoplastic; Guanine; Humans; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Random Allocation; RNA Interference; Survivin; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2015
A specific photoimmunotheranostics agent to detect and eliminate skin cancer cells expressing EGFR.
    Journal of cancer research and clinical oncology, 2016, Volume: 142, Issue:5

    Topics: Carcinoma, Squamous Cell; ErbB Receptors; Flow Cytometry; Fluorescent Dyes; Guanine; Humans; Immunotherapy; Indoles; Melanoma; Microscopy, Confocal; Organosilicon Compounds; Photochemotherapy; Photosensitizing Agents; Recombinant Fusion Proteins; Single-Chain Antibodies; Skin Neoplasms; Tumor Cells, Cultured

2016
A Monoclonal Antibody That Discriminates Between SNAP-Tagged and CLIP-Tagged Proteins.
    Monoclonal antibodies in immunodiagnosis and immunotherapy, 2016, Volume: 35, Issue:3

    Topics: Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Dyes; Guanine; Recombinant Fusion Proteins

2016
The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts.
    Nucleic acids research, 2016, 08-19, Volume: 44, Issue:14

    Topics: Base Pairing; Carcinogens; DNA; DNA Adducts; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Kinetics; Models, Molecular; Nucleotides; Reproducibility of Results; Taq Polymerase; Templates, Genetic

2016
Photoimmunotheranostic agents for triple-negative breast cancer diagnosis and therapy that can be activated on demand.
    Oncotarget, 2016, Aug-23, Volume: 7, Issue:34

    Topics: Cell Line, Tumor; Cell Survival; Chondroitin Sulfate Proteoglycans; Epithelial Cell Adhesion Molecule; ErbB Receptors; Female; Guanine; Humans; Immunoconjugates; Indoles; Isoindoles; Light; MCF-7 Cells; Membrane Proteins; Microscopy, Confocal; Organosilicon Compounds; Photochemotherapy; Photosensitizing Agents; Recombinant Fusion Proteins; Single-Chain Antibodies; Triple Negative Breast Neoplasms

2016
Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.
    Oncotarget, 2016, Sep-13, Volume: 7, Issue:37

    Topics: Animals; B-Lymphocytes; Cell Death; Cell Line; Chickens; DNA Breaks, Double-Stranded; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Fanconi Anemia; Fanconi Anemia Complementation Group Proteins; Guanine; Humans; Mesylates; Micronuclei, Chromosome-Defective; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Proteins

2016
A Fluorescent Reporter for Single Cell Analysis of Gene Expression in Clostridium difficile.
    Methods in molecular biology (Clifton, N.J.), 2016, Volume: 1476

    Topics: Aldehydes; Anaerobiosis; Base Sequence; Benzyl Compounds; Clostridioides difficile; Cytosine; Fluorescent Dyes; Gene Expression Regulation, Bacterial; Genes, Reporter; Guanine; Humans; Indoles; Microscopy, Fluorescence; O(6)-Methylguanine-DNA Methyltransferase; Peptides; Plasmids; Pyridinium Compounds; Quaternary Ammonium Compounds; Single-Cell Analysis; Staining and Labeling

2016
iRGD-mediated core-shell nanoparticles loading carmustine and O
    Journal of drug targeting, 2017, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Glioma; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Nanoparticles; Oligopeptides; Tumor Microenvironment

2017
Specifically and wash-free labeling of SNAP-tag fused proteins with a hybrid sensor to monitor local micro-viscosity.
    Biosensors & bioelectronics, 2017, May-15, Volume: 91

    Topics: Alkyl and Aryl Transferases; Animals; Biosensing Techniques; Boron Compounds; Chlorocebus aethiops; COS Cells; Electron Transport Complex IV; Fluorescent Dyes; Guanine; Histones; Humans; Models, Molecular; Optical Imaging; Recombinant Fusion Proteins; Viscosity

2017
Toward Discovery of Novel Microtubule Targeting Agents: A SNAP-tag-Based High-Content Screening Assay for the Analysis of Microtubule Dynamics and Cell Cycle Progression.
    SLAS discovery : advancing life sciences R & D, 2017, Volume: 22, Issue:4

    Topics: A549 Cells; Antineoplastic Agents; Cell Cycle; Dose-Response Relationship, Drug; Drug Discovery; Guanine; High-Throughput Screening Assays; Humans; Microtubules; Nocodazole; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Small Molecule Libraries; Tubulin; Tubulin Modulators

2017
Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs.
    Nature methods, 2018, Volume: 15, Issue:7

    Topics: Adenosine Deaminase; Animals; Base Sequence; Cell Line; Guanine; Humans; RNA Editing; RNA-Binding Proteins; SNARE Proteins

2018
Hepatic Flavin-containing Monooxygenase and Aldehyde Oxidase Activities in Male Domestic Pigs at Different Ages.
    Drug metabolism letters, 2018, Volume: 12, Issue:2

    Topics: Age Factors; Aldehyde Oxidase; Animals; Benzydamine; Guanine; Liver; Male; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Sus scrofa

2018
Evaluation of Carbazeran 4-Oxidation and
    Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:1

    Topics: Aldehyde Oxidase; Biocatalysis; Biomarkers; Calibration; Carbamates; Cytochrome P-450 Enzyme System; Cytosol; Drug Development; Guanine; Humans; Microsomes, Liver; Oxidation-Reduction; Reference Standards

2019
Beyond O
    Bioconjugate chemistry, 2018, 12-19, Volume: 29, Issue:12

    Topics: Fluorescent Dyes; Guanine; HeLa Cells; Humans; Mass Spectrometry; Substrate Specificity; Zinc

2018
Methylation Tolerance-Based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome.
    Gastroenterology, 2019, Volume: 157, Issue:2

    Topics: Biological Assay; Cell Line, Tumor; Colorectal Neoplasms, Hereditary Nonpolyposis; Computer Simulation; DNA Methylation; DNA Mismatch Repair; Feasibility Studies; Genetic Testing; Germ-Line Mutation; Guanine; Humans; Methylnitronitrosoguanidine; MutL Protein Homolog 1; MutS Homolog 2 Protein

2019
Site-Specific Immobilization of β
    Analytical chemistry, 2019, 06-04, Volume: 91, Issue:11

    Topics: Cinnamates; Depsides; Drug Discovery; Guanine; High-Throughput Screening Assays; Humans; Ligands; Perilla; Receptors, Adrenergic, beta-2; Rosmarinic Acid; Surface Properties

2019
MGMT-inhibitor in combination with TGF-βRI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021, Volume: 23, Issue:3

    Topics: Aminopyridines; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytes; Benzimidazoles; Brain Neoplasms; Cell Cycle; Cell Survival; Cells, Cultured; Cyclin D; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; G1 Phase Cell Cycle Checkpoints; Glioblastoma; Guanine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neurons; Phosphatidylinositol 3-Kinases; Pyrazoles; Quinolines; Receptor, Transforming Growth Factor-beta Type I; Smad Proteins; Temozolomide; Tumor Suppressor Proteins

2021
Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey.
    Drug metabolism and disposition: the biological fate of chemicals, 2020, Volume: 48, Issue:12

    Topics: Aldehyde Oxidase; Animals; Coenzymes; Dantrolene; Drug Evaluation, Preclinical; Guanine; Macaca fascicularis; Metalloproteins; Molybdenum Cofactors; Mutagenesis, Site-Directed; Oxidation-Reduction; Pteridines; Sequence Homology, Amino Acid; Species Specificity; Substrate Specificity

2020
The O6-methyguanine-DNA methyltransferase inhibitor O6-benzylguanine enhanced activity of temozolomide + irinotecan against models of high-risk neuroblastoma.
    Anti-cancer drugs, 2021, 03-01, Volume: 32, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Guanine; Humans; Irinotecan; Mice; Neuroblastoma; O(6)-Methylguanine-DNA Methyltransferase; Real-Time Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Up-Regulation

2021