Compounds > o(6)-benzylguanine

o(6)-benzylguanine and deoxyguanosine

o(6)-benzylguanine has been researched along with deoxyguanosine in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dolan, ME; Erickson, LC; Marathi, UK1
Bocangel, DB; Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC1
Ahmed, MM; Chendil, D; Kokkinakis, DM; Moschel, RC; Pegg, AE1
Bacolod, MD; Bigner, DD; Bullock, NS; Colvin, OM; Dolan, ME; Fang, Q; Friedman, HS; Johnson, SP; Modrich, P; Moschel, RC; Pegg, AE1
Loktionova, NA; Moschel, RC; Pegg, AE; Wei, G1
Cao, Q; Peterson, LA; Upadhyaya, P; Urban, AM1
Fan, T; Li, S; Sun, G; Zhao, L; Zhong, R1

Other Studies

7 other study(ies) available for o(6)-benzylguanine and deoxyguanosine

ArticleYear
Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Cancer research, 1994, Aug-15, Volume: 54, Issue:16

    Topics: Antineoplastic Agents; Carmustine; Deoxyguanosine; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Dacarbazine; Deoxyguanosine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured

2001
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Sep-01, Volume: 9, Issue:10 Pt 1

    Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarbazine; Deoxyguanosine; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Time Factors

2003
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:9

    Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic

2004
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
    Journal of medicinal chemistry, 2005, Jan-13, Volume: 48, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biochemistry; Carmustine; Cattle; Cell Death; Deoxyguanosine; Drug Stability; Enzyme Activation; Escherichia coli; Glucuronidase; Guanine; HT29 Cells; Humans; Hydrolysis; Kinetics; Liver; Prodrugs

2005
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Animals; Carcinogens; Deoxyguanosine; DNA Adducts; Enzyme Inhibitors; Female; Guanine; Lung; Lung Neoplasms; Mice; Mutagens; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines

2012
Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tand
    Chemical research in toxicology, 2014, Jul-21, Volume: 27, Issue:7

    Topics: Alkylating Agents; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyguanosine; DNA; DNA Damage; Ethylnitrosourea; Glioma; Guanine; Humans; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014