o(6)-benzyl-2'-deoxyguanosine has been researched along with deoxyguanosine in 16 studies
| Studies (o(6)-benzyl-2'-deoxyguanosine) | Trials (o(6)-benzyl-2'-deoxyguanosine) | Recent Studies (post-2010) (o(6)-benzyl-2'-deoxyguanosine) | Studies (deoxyguanosine) | Trials (deoxyguanosine) | Recent Studies (post-2010) (deoxyguanosine) |
|---|---|---|---|---|---|
| 19 | 1 | 1 | 6,470 | 225 | 2,167 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dolan, ME; Erickson, LC; Marathi, UK | 1 |
| Kokkinakis, DM; Moschel, RC; Pegg, AE; Rudy, JL; Schold, SC | 1 |
| Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC | 1 |
| Bocangel, DB; Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC | 1 |
| Chen, ZP; Huang, Q; Pan, J; Sun, ZF; Wang, AD; Zhou, LY | 1 |
| Intano, GW; Sung, HM; Walter, CA; Walter, RB | 1 |
| Ahmed, MM; Chendil, D; Kokkinakis, DM; Moschel, RC; Pegg, AE | 1 |
| Berger, MS; Chang, SM; Davis, RL; Fink, KL; Hess, KR; Kokkinakis, DM; Mehta, MP; Prados, MD; Robins, HI; Schiff, D; Schold, SC | 1 |
| Bacolod, MD; Bigner, DD; Bullock, NS; Colvin, OM; Dolan, ME; Fang, Q; Friedman, HS; Johnson, SP; Modrich, P; Moschel, RC; Pegg, AE | 1 |
| Fairbairn, LJ; Humphries, RK; Margison, GP; Milsom, MD; Woolford, LB | 1 |
| Loktionova, NA; Moschel, RC; Pegg, AE; Wei, G | 1 |
| Shankar, S; Vaidyanathan, G; Zalutsky, MR | 1 |
| Fang, Q; Guengerich, FP; Pegg, AE; Zang, H | 1 |
| Abdel-Wahab, OI; Abdel-Wahab, Z; Augustine, C; Cheng, TY; Friedman, HS; Grubbs, E; Ko, SH; Pruitt, SK; Tyler, DS; Ueno, T; Yoshimoto, Y | 1 |
| Fang, Q; Javanmard, S; Loktionova, NA; Moschel, RC; Pauly, GT; Pegg, AE | 1 |
| Dhummakupt, E; Egli, M; Kowal, EA; Lad, RR; Pallan, PS; Stone, MP; Sturla, SJ; Wawrzak, Z | 1 |
1 trial(s) available for o(6)-benzyl-2'-deoxyguanosine and deoxyguanosine
| Article | Year |
|---|---|
O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas.
Topics: Adult; Aged; Alkyl and Aryl Transferases; Astrocytoma; Brain Neoplasms; Deoxyguanosine; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Glioblastoma; Humans; Injections, Intravenous; Logistic Models; Male; Middle Aged | 2004 |
15 other study(ies) available for o(6)-benzyl-2'-deoxyguanosine and deoxyguanosine
| Article | Year |
|---|---|
Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
Topics: Antineoplastic Agents; Carmustine; Deoxyguanosine; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1994 |
Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Death; Deoxyguanosine; Humans; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous | 1996 |
Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Cerebellar Neoplasms; Deoxyguanosine; Humans; Inflammation; Intestinal Mucosa; Medulloblastoma; Mice; Mice, Nude; Mitosis; O(6)-Methylguanine-DNA Methyltransferase; Transplantation, Heterologous; Tumor Cells, Cultured; Weight Loss | 1999 |
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Dacarbazine; Deoxyguanosine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Antitumor efficacy of SarCNU in a human glioma xenograft model expressing both MGMT and extraneuronal monoamine transporter.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Carrier Proteins; Cell Line; Deoxyguanosine; Female; Glioma; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Organic Cation Transport Proteins; Transplantation, Heterologous | 2001 |
Characterization of O(6)-methylguanine-DNA-methyltransferase (O(6)-MGMT) activity in Xiphophorus fishes.
Topics: Animals; Base Sequence; Cyprinodontiformes; Deoxyguanosine; DNA Adducts; DNA Repair; Enzyme Inhibitors; Escherichia coli; Female; Humans; Kinetics; Male; Mammals; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Species Specificity; Substrate Specificity; Temperature; Tissue Distribution | 2001 |
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarbazine; Deoxyguanosine; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Time Factors | 2003 |
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic | 2004 |
Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.
Topics: Animals; Bone Marrow Cells; Cell Line; Colony-Forming Units Assay; Dacarbazine; Deoxyguanosine; Genetic Vectors; Green Fluorescent Proteins; Hematopoietic Stem Cell Transplantation; Homeodomain Proteins; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Temozolomide; Transcription Factors | 2004 |
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biochemistry; Carmustine; Cattle; Cell Death; Deoxyguanosine; Drug Stability; Enzyme Activation; Escherichia coli; Glucuronidase; Guanine; HT29 Cells; Humans; Hydrolysis; Kinetics; Liver; Prodrugs | 2005 |
O6-3-[125I]iodobenzyl-2'-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT).
Topics: Cell Line, Tumor; Deoxyguanosine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Iodine Radioisotopes; O(6)-Methylguanine-DNA Methyltransferase; Radiopharmaceuticals | 2005 |
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase.
Topics: Base Sequence; Deoxyguanosine; DNA; DNA Damage; DNA Repair; Guanosine; Humans; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides | 2005 |
Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Dacarbazine; Deoxyguanosine; Drug Resistance, Neoplasm; Humans; Injections, Intra-Arterial; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Skin Neoplasms; Temozolomide; Xenograft Model Antitumor Assays | 2006 |
Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.
Topics: Antineoplastic Agents, Alkylating; Carmustine; Carrier Proteins; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Esters; Folate Receptors, GPI-Anchored; Folic Acid; Guanine; Humans; Hydrolysis; O(6)-Methylguanine-DNA Methyltransferase; Receptors, Cell Surface; Solubility; Structure-Activity Relationship | 2007 |
Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.
Topics: Base Pairing; Base Sequence; Deoxyguanosine; DNA; Glycosylation; Guanine; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Nucleosides; Thermodynamics; Thymine | 2013 |