nystatin-a1 and titanium-tetrafluoride

The aim of this study was to evaluate antifungal effects of calcium-chelating or -binding agents on Candida albicans comparing with conventional antifungal agents.. Two clinical oral isolates and 1 standard strain of C albicans were included in the study. Test solutions were ethylenediamine-tetraacetic acid (EDTA), ethyleneglycol-tetraacetic acid (EGTA), sodium fluoride (NaF), titanium tetrafluoride (TiF4), nystatin, and ketoconazole. Minimum inhibitory and fungicidal concentrations of the solutions were determined. The results were analyzed statistically using Friedman's nonparametric 2-way ANOVA and Mann-Whitney U tests.. All isolates demonstrated similar susceptibility patterns (P>.05). Except ketoconazole, EDTA had the highest antifungal and fungicidal activity, followed by TiF4. EGTA and NaF were the weakest agents against C albicans among all test solutions.. EDTA and TiF4 may be recommended as an alternative irrigating solution particularly in persistent root canal infections and in root canals of patients having a high incidence of oral candidosis.

Topics: Analysis of Variance; Antifungal Agents; Calcium; Candida albicans; Chelating Agents; Edetic Acid; Egtazic Acid; Fluorides; Ketoconazole; Microbial Sensitivity Tests; Nystatin; Root Canal Irrigants; Sodium Fluoride; Statistics, Nonparametric; Titanium