nystatin-a1 and isoconazole

Topics: Adult; Clinical Trials as Topic; Female; Humans; Miconazole; Middle Aged; Mycoses; Nystatin; Random Allocation; Vaginitis

The results of all the controlled trials carried out at the Department of Genito-Urinary Medicine at the Cardiff Royal Infirmary over the past 16 years are summarized. All except one of these trials were carried out with patients having acute vulvovaginal candidiasis. One trial involved treating only patients with recurring candidal infection. In all the acute trials, there were practically no mycologic relapses 7 days after completion of treatment whatever the regimen used, but at 35 days after completion of treatment the mycologic relapse rate was in the region of 20% to 25%. It is concluded that following the elimination of any known predisposing cause of vaginal candidiasis, the intravaginal application of 500 mg of an imidazole preparation is as effective a treatment as any other regimen. In recurrent cases, monthly treatment with such a dose may be adequate to control the patient's symptoms. Mycologic relapse may not be accompanied by symptoms, but in recurrent cases there is a closer relation between mycologic relapse and symptoms.

Topics: Amphotericin B; Antifungal Agents; Candidiasis, Vulvovaginal; Clinical Trials as Topic; Clotrimazole; Double-Blind Method; Drug Administration Schedule; Econazole; Female; Follow-Up Studies; Humans; Imidazoles; Miconazole; Nystatin; Pessaries; Recurrence; Vaginal Creams, Foams, and Jellies; Wales

The inhibitory activity of some antifungal agents against 17 strains of genus Epidermophyton have been studied. The behaviour of Epidermophyton stockdaleae against antifungal agents tested is clearly different from that observed in the strains belonging to Epidermophyton floccosum, since all of the latter were sensitive to the antifungal agents used and the geophilic species showed resistance to griseofulvin, isoconazole, natamycin and nystatin, and intermediate sensitivity to ketoconazole and miconazole. The low sensitivity of E. stockdaleae (and other geophilic dermatophytes) to antifungal agents could be a problem in the current therapy if further studies or case reports demonstrate their pathogenic role.

Topics: Antifungal Agents; Clotrimazole; Econazole; Epidermophyton; Griseofulvin; Imidazoles; Ketoconazole; Miconazole; Natamycin; Nystatin

Topics: Adolescent; Adult; Aged; Antifungal Agents; Candida; Candidiasis, Cutaneous; Child; Ciclopirox; Clotrimazole; Econazole; Female; Humans; Imidazoles; Male; Miconazole; Middle Aged; Nystatin; Pyridones

The early events in the interaction of two polyene (amphotericin B and nystatin) and five imidazole (clotrimazole, ketoconazole, miconazole, isoconazole, and econazole) antimycotics used at fungicidal concentrations with the surface of Candida albicans were studied by scanning electron microscopic examination of treated intact young yeast cells, treated spheroplasts, and spheroplasts liberated from treated young yeast cells. In all cases, treatment lasted 2 h. The polyenes passed through the yeast cell wall and interacted with the cytoplasmic membrane causing the spheroplasts to lose their characteristic spheric form and to liberate their contents. Clotrimazole caused the formation of numerous circular openings in the cytoplasmic membrane, but only when the agent was used to treat spheroplasts directly. Ketoconazole, miconazole, isoconazole, and econazole interacted with the cell wall causing formation of convolutions and wrinkles. The three imidazole derivatives that are structurally closely related, miconazole, isoconazole, and econazole, inhibited the enzyme-catalyzed release of spheroplasts from young yeast cells.

Topics: Amphotericin B; Antifungal Agents; Candida albicans; Cell Membrane; Cell Wall; Clotrimazole; Econazole; Imidazoles; Ketoconazole; Miconazole; Microscopy, Electron, Scanning; Nystatin; Piperazines