nystatin-a1 has been researched along with amipurimycin* in 1 studies
1 other study(ies) available for nystatin-a1 and amipurimycin
| Article | Year |
|---|---|
Synthesis of an adenine nucleoside containing the (8'R) epimeric carbohydrate core of amipurimycin and its biological study.
The (8'R) epimeric carbohydrate core 2 of amipurimycin was synthesized from D-glucose derived allylic alcohol 3 in 11 steps and 13% overall yield. The key steps involve an acid-catalyzed acetonide ring opening of 9 with concomitant formation of an unprecedented pyranose ring skeleton to give 2,7-dioxabicyclo[3.2.1]octane 10. The α-orientation of the furan ring in 10 readily allows the stereoselective β-glycosylation and opening of the furanose ring that on removal of protecting groups affords the pyranosyl adenine nucleoside 2. The antifungal and anticancer activities of 2 were studied. Topics: Acids; Adenine; Antifungal Agents; Antineoplastic Agents; Carcinoma; Catalysis; Cell Proliferation; Female; Fungi; Glucose; Glycosylation; HeLa Cells; Humans; Nystatin; Octanes; Purines; Stereoisomerism; Structure-Activity Relationship; Uterine Cervical Neoplasms | 2011 |