nutlin 3 and nutlin-3a
nutlin 3 has been researched along with nutlin-3a in 4 studies
Compound Research Comparison
| Studies (nutlin 3) | Trials (nutlin 3) | Recent Studies (post-2010) (nutlin 3) | Studies (nutlin-3a) | Trials (nutlin-3a) | Recent Studies (post-2010) (nutlin-3a) |
|---|---|---|---|---|---|
| 12 | 0 | 10 | 698 | 1 | 504 |
Protein Interaction Comparison
| Protein | Taxonomy | nutlin 3 (IC50) | nutlin-3a (IC50) |
|---|---|---|---|
| Protein Mdm4 | Homo sapiens (human) | 4.6273 | |
| Cellular tumor antigen p53 | Homo sapiens (human) | 1.0388 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.07 | |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | 0.1832 |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ding, K; Gao, W; Krajewski, K; Lu, Y; Nikolovska-Coleska, Z; Qin, D; Qiu, S; Roller, PP; Shangary, S; Stuckey, J; Wang, G; Wang, S | 1 |
| Fang, X; Gao, W; Lu, Y; Nikolovska-Coleska, Z; Qin, D; Qiu, S; Shangary, S; Wang, S | 1 |
| Aonuma, M; Fukutake, S; Ikeda, M; Kawato, H; Kitagawa, M; Miyazaki, M; Naito, H; Seki, T; Soga, T | 1 |
| Liu, Y; Ouyang, L; Wang, G; Wang, X; Yang, Y; Yuan, Y | 1 |
Reviews
1 review(s) available for nutlin 3 and nutlin-3a
| Article | Year |
|---|---|
The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds; Humans; Mutation; Protein Binding; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2019 |
Other Studies
3 other study(ies) available for nutlin 3 and nutlin-3a
| Article | Year |
|---|---|
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Membrane Permeability; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Indoles; Models, Molecular; Protein Binding; Proto-Oncogene Proteins c-mdm2; Spiro Compounds; Structure-Activity Relationship; Tumor Suppressor Protein p53 | 2006 |
Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.
Topics: Aniline Compounds; Antineoplastic Agents; Binding Sites; Binding, Competitive; Cell Line, Tumor; Crystallography, X-Ray; Databases, Factual; HCT116 Cells; Humans; Hydroxyquinolines; Models, Molecular; Molecular Mimicry; Mutation; Proto-Oncogene Proteins c-mdm2; Stereoisomerism; Tumor Suppressor Protein p53 | 2006 |
Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships.
Topics: Drug Design; Humans; Imidazoles; Neoplasms; Protein Interaction Maps; Proto-Oncogene Proteins c-mdm2; Thiazoles; Tumor Suppressor Protein p53 | 2012 |