Compounds > nu6102

nu6102 and nu2058

nu6102 has been researched along with nu2058 in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bentley, J; Boyle, FT; Calvert, AH; Cheng, Y; Curtin, NJ; Endicott, JA; Golding, BT; Griffin, RJ; Hardcastle, IR; Jewsbury, P; Mesguiche, V; Newell, DR; Noble, ME; Parsons, RJ; Pratt, DJ; Sayle, KL; Wang, LZ1
Arris, CE; Bentley, J; Boyle, FT; Chen, Y; Curtin, NJ; Endicott, JA; Gibson, AE; Golding, BT; Griffin, RJ; Hardcastle, IR; Jewsbury, P; Menyerol, J; Mesguiche, V; Newell, DR; Noble, ME; Pratt, DJ; Wang, LZ; Whitfield, HJ1
Anscombe, E; Campbell, AJ; Cano, C; Carbain, B; Echalier, A; Endicott, JA; Golding, BT; Griffin, RJ; Haggerty, K; Hardcastle, IR; Jewsbury, PJ; Newell, DR; Noble, ME; Paterson, DJ; Roche, C; Wang, LZ1
Anscombe, E; Cano, C; Carbain, B; Coxon, CR; Endicott, JA; Golding, BT; Griffin, RJ; Hardcastle, IR; Harlow, LK; Harnor, SJ; Korolchuk, S; Martin, MP; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C1
Caldon, EC; Tadesse, S; Tilley, W; Wang, S1
Arris, CE; Bentley, J; Boyle, FT; Curtin, NJ; Davies, TG; Endicott, JA; Gibson, AE; Golding, BT; Griffin, RJ; Hardcastle, IR; Jewsbury, P; Johnson, LN; Mesguiche, V; Newell, DR; Noble, ME; Tucker, JA; Wang, L; Whitfield, HJ1
Artacho, E; Ciacchi, LC; Fernandez-Serra, M; Heady, L; Joyce, S; Mancera, RL; Payne, MC; Skylaris, CK; Venkitaraman, AR1

Reviews

1 review(s) available for nu6102 and nu2058

ArticleYear
Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.
    Journal of medicinal chemistry, 2019, 05-09, Volume: 62, Issue:9

    Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Cyclin-Dependent Kinase 2; Drug Design; Humans; Neoplasms; Protein Binding; Protein Conformation; Protein Kinase Inhibitors

2019

Other Studies

6 other study(ies) available for nu6102 and nu2058

ArticleYear
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.
    Bioorganic & medicinal chemistry letters, 2003, Sep-15, Volume: 13, Issue:18

    Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Molecular Structure; Protein Binding; Pyrimidines; Structure-Activity Relationship

2003
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
    Journal of medicinal chemistry, 2004, Jul-15, Volume: 47, Issue:15

    Topics: Animals; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclohexanes; Guanine; Humans; Models, Molecular; Purines; Starfish; Structure-Activity Relationship

2004
8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode.
    Journal of medicinal chemistry, 2014, Jan-09, Volume: 57, Issue:1

    Topics: Binding Sites; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Drug Design; Models, Molecular; Protein Kinase Inhibitors; Structure-Activity Relationship

2014
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
    Journal of medicinal chemistry, 2017, 03-09, Volume: 60, Issue:5

    Topics: Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Protein Kinase Inhibitors; Purines; Spectrum Analysis; Structure-Activity Relationship

2017
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor.
    Nature structural biology, 2002, Volume: 9, Issue:10

    Topics: CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Guanine; Humans; Protein Serine-Threonine Kinases; Purines; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.
    Journal of medicinal chemistry, 2006, Aug-24, Volume: 49, Issue:17

    Topics: Adenosine Triphosphate; Binding Sites; Computer Simulation; Crystallography; Cyclin-Dependent Kinase 2; Guanine; Humans; Hydrogen Bonding; Imidazoles; Indoles; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; Nitroso Compounds; Protein Conformation; Protein Structure, Tertiary; Purines; Pyrimidines; Staurosporine; Structure-Activity Relationship

2006