nu2058 has been researched along with guanine in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arris, CE; Bentley, J; Boyle, FT; Curtin, NJ; Davies, TG; Endicott, JA; Gibson, AE; Golding, BT; Griffin, RJ; Hardcastle, IR; Jewsbury, P; Johnson, LN; Mesguiche, V; Newell, DR; Noble, ME; Tucker, JA; Wang, L; Whitfield, HJ | 1 |
| Ferguson, M; Fersht, A; Finlan, L; Hupp, TR; Ibbotson, S; Luciani, MG; Rankin, EM | 1 |
| Artacho, E; Ciacchi, LC; Fernandez-Serra, M; Heady, L; Joyce, S; Mancera, RL; Payne, MC; Skylaris, CK; Venkitaraman, AR | 1 |
| Curtin, NJ; Rigas, AC; Robson, CN | 1 |
| Dolan, ME; Harrison, LR; Newell, DR; Ottley, CJ; Pearson, DG; Roche, C; Tilby, MJ; Wedge, SR | 1 |
| Anand-Srivastava, MB; El Andalousi, J; Li, Y | 1 |
6 other study(ies) available for nu2058 and guanine
| Article | Year |
|---|---|
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor.
Topics: CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Guanine; Humans; Protein Serine-Threonine Kinases; Purines; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death.
Topics: Antineoplastic Agents; Binding Sites; CDC2-CDC28 Kinases; Cell Death; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Guanine; Humans; Mutation; Peptide Fragments; Phosphorylation; Protein Binding; Purines; Roscovitine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2004 |
Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.
Topics: Adenosine Triphosphate; Binding Sites; Computer Simulation; Crystallography; Cyclin-Dependent Kinase 2; Guanine; Humans; Hydrogen Bonding; Imidazoles; Indoles; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; Nitroso Compounds; Protein Conformation; Protein Structure, Tertiary; Purines; Pyrimidines; Staurosporine; Structure-Activity Relationship | 2006 |
Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer.
Topics: Androgens; Anilides; CDC2 Protein Kinase; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Guanine; Humans; Male; Nitriles; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Retinoblastoma Protein; Tosyl Compounds | 2007 |
The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclin-Dependent Kinase 2; DNA Adducts; Drug Synergism; Guanine; Humans; Protein Kinase Inhibitors; Tumor Stem Cell Assay | 2009 |
Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling.
Topics: Animals; Atrial Natriuretic Factor; Cell Cycle Proteins; Cell Proliferation; Cyclin D; Cyclin-Dependent Kinases; DNA; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Guanine; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peptide Fragments; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Receptors, Atrial Natriuretic Factor; Retinoblastoma Protein; Thiazoles | 2013 |